Digital Commons Network^™

Articles That May Change Your Practice: Reviewing Intraosseous Or Intravenous? Reviewing Intraosseous Versus Intravenous First Approach To Access In Out-Of-Hospital Cardiac Arrest Data From Randomized Controlled Trials, Blaise Loughman, Fatou Ndaw, Aaron J Lacy, James L Li

2020-Current year OA Pubs

No abstract provided.

Articles That May Change Your Practice: Double-Sequential External Defibrillation In Out-Of-Hospital Cardiac Arrest, Michael J Defilippo, Christianne L Jafari, James L Li, Aaron J Lacy

2020-Current year OA Pubs

No abstract provided.

Articles That May Change Your Practice: Prehospital Extracorporeal Membrane Oxygenation Alerts And Extracorporeal Cardiopulmonary Resuscitation In Out-Of-Hospital Cardiac Arrest, James L Li, Aaron J Lacy, Bridgette B Svancarek

2020-Current year OA Pubs

No abstract provided.

Managing Tbsrtc Iii Thyroid Nodules: Evaluating Repeat Fna, Molecular Testing, And Surgery, Christopher Dilli, William Mi, Daniel L Miller

2020-Current year OA Pubs

INTRODUCTION: Thyroid nodules are common, but most are benign. Concerning nodules undergo fine-needle aspiration (FNA) and are classified using The Bethesda System. Nodules with atypia of undetermined significance (AUS) [Bethesda III] have management options including surveillance, repeat FNA, molecular testing, and surgical evaluation. While molecular testing can reduce unnecessary surgeries, it is costly. This retrospective study assessed the feasibility of repeat FNA as a cost-effective alternative.

MATERIALS AND METHODS: We conducted a multi-institutional retrospective study of AUS nodules from 5 hospitals between September 1, 2018, and March 1, 2024. Only initial FNA cases were included; pediatric cases and those lost …

Surgeon Interpretation Of Patient-Reported Outcome Measures In Upper Extremity Osteoarthritis, Rick S. Looman, Koen Oude Nijhuis, Sina Ramtin, David Ring, Daniel A. London, Ryan Calfee, Niels Brinkman, Science Of Variation Group

2020-Current year OA Pubs

PURPOSE: Measures that quantify levels of pain intensity, incapability, symptoms of distress, and unhelpful thinking were designed as research tools. We studied how surgeons interpret and act on these scores in the care of individual patients.

METHODS: In an online experiment, 67 upper limb specialists from the Science of Variation Group reviewed 10 fictious patient scenarios of trapeziometacarpal, wrist and elbow osteoarthritis (OA) and randomized elements of radiographic severity, levels of discomfort and incapability, deprivation index score (social health), and levels of distress and unhelpful thinking (mental health). Multilevel mixed-effects linear regression identified patient factors associated with surgeon concern, enthusiasm …

Concomitant Traumatic Brain Injury Exacerbates Endotheliopathy In Patients With Spinal Cord Injury, Shahab Hafezi, Miguel A. Ruiz-Cardozo, Sarbani Ghosh, Sravanthi Bandla, Matthew N. Montoya Rush, Anand Dharmarajan, Mark H. Hoofnagle, Isaiah R. Turnbull, Camilo A. Molina, Grace M. Niziolek

2020-Current year OA Pubs

No abstract provided.

Sociodemographic Factors Predict Outcomes And Reveal Spatial Tumor Patterns In Glioblastoma, Patrick H Luckett, Michael Olufawo, Noah Naddaff-Slocum, Ki Yun Park, Bidhan Lamichhane, Donna Dierker, Gabriel Trevino Verastegui, John J Lee, Peter Yang, Albert Kim, Omar H Butt, Milan G Chheda, Abraham Z Snyder, Joshua S Shimony, Eric C Leuthardt

2020-Current year OA Pubs

BACKGROUND: Glioblastoma (GBM) is the deadliest malignant glioma of the central nervous system. Postsurgical functional impairment correlates with survival and is estimated using metrics such as extent and location of resection. This study uses machine learning to evaluate the predictive ability of baseline sociodemographic and lifestyle factors for forecasting postoperative functional outcomes in GBM patients.

METHODS: Glioblastoma patients (

RESULTS: Utilizing decision trees with age, SVI/SES, sex, tobacco use, alcohol use, obesity, and race as predictors, we achieved 88% accuracy in classifying median KPS and 85% accuracy in classifying KPS slope. Socioeconomic factors were the strongest predictors. Age, sex, and …

Recombinant Human Alpha-N-Acetylglucosamine-6-Sulfatase Delivered To Sanfilippo D Mice With Repeated Intracerebroventricular Injections Corrects Cns Pathology, Grant L. Austin, Feng Wang, Steven Q. Le, Alexander Sorensen, Shan Li, Lai C. Foong, Srikanth Singamsetty, Jill Wood, Tsui-Fen Chou, Patricia I. Dickson

2020-Current year OA Pubs

Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo D) is caused by biallelic pathogenic variants in N-acetylglucosamine-6-sulfatase (GNS), which participates in catabolism of heparan sulfate (HS) glycosaminoglycans. Characterization of MPS IIID disease at a cellular level has not been robustly achieved. We used unbiased quantitative proteomics to establish a cellular phenotype for MPS IIID mice. Recombinant human GNS (rhGNS), a variant of which previously demonstrated single dose efficacy in MPS IIID human fibroblasts and in MPS IIID neonatal mice, was used to establish a repeat dosing schedule to treat MPS IIID mice. Adult Gns KO mice or heterozygous carriers were treated via …

Piezo1-Mediated Calcium Influx Transiently Alters Nuclear Mechanical Properties Via Actin Remodeling In Chondrocytes, Jaquelin M Garcia-Castorena, Rosa Riester, Miranda Gamino-Ornelas, Nikitha Ada, Farshid Guilak, Marina Danalache

2020-Current year OA Pubs

Mechanosensation allows cells to generate intracellular signals in response to mechanical cues from their environment. Previous research has demonstrated that mechanical stress can alter the mechanical properties of the nucleus, affecting gene transcription, chromatin methylation, and nuclear mechanoprotection during mechanical loading. PIEZO1, a mechanically gated Ca

Expert Consensus On The Diagnosis And Management Of Digoxin Toxicity, Jason B Hack, Sue Wingate, Ron Zolty, Michael W Rich, Paul J Hauptman

2020-Current year OA Pubs

While there has been a decline in the use of digoxin in patients with heart failure and atrial fibrillation, acute and chronic digoxin toxicity remains a significant clinical problem. Digoxin's narrow therapeutic window and nonspecific signs and symptoms of toxicity create clinical challenges and uncertainty around the diagnostic criteria of toxicity and responsive treatment choices for the bedside clinician. A systematic review of published literature on digoxin toxicity (34,587 publications over 6 decades, with 114 meeting inclusion criteria) was performed to develop 33 consensus statements on diagnostic and therapeutic approaches which were then evaluated through a modified Delphi process involving …

Reliability Of Wrist Arthroscopy In The Diagnosis And Treatment Of Triangular Fibrocartilage Complex Tears, Elizabeth A Graesser, Lindley B Wall, Sanjeev Kakar, Jeffrey Yao, Marc J Richard, R Glenn Gaston, Charles A Goldfarb

2020-Current year OA Pubs

PURPOSE: Wrist arthroscopy is considered the gold standard for diagnosis of intra-articular wrist conditions including triangular fibrocartilage complex (TFCC) tears; however, the ability to reliably diagnose TFCC pathology during wrist arthroscopy is unclear. The purpose of this study was to assess the reliability of the diagnosis of TFCC tears on wrist arthroscopy videos.

METHODS: Five hand surgeons reviewed 43 cases on a secure web-based platform at two time points separated by 4-6 weeks. Each case included a deidentified clinical vignette and wrist radiographs with ulnar variance measurements and an arthroscopy video of ulnar wrist pathology, averaging 42 seconds. Surgeons were …

Diagnosis And Management Of Gastroesophageal Reflux Disease: Current Insights, Abhinav Vayal-Veettil, C Prakash Gyawali

2020-Current year OA Pubs

Gastroesophageal reflux disease (GERD) results from retrograde movement of gastric content into the esophagus and beyond, resulting in symptoms, mucosal injury and long-term complications. Typical symptoms of heartburn and regurgitation are highly suggestive of GERD, but atypical presentations require careful evaluation to rule out alternative diagnoses. Diagnostic modalities, including endoscopy, ambulatory reflux monitoring, and high-resolution manometry, play a pivotal role in confirming GERD and guiding personalized treatment. Management strategies consist of lifestyle modifications, pharmacologic therapy with anti-secretory agents, and adjunctive treatments such as alginates and baclofen. For refractory cases, surgical and endoscopic interventions offer durable symptom relief. Complications of GERD …

Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

We summarize research reports from 2024 relevant to Tourette syndrome, which the authors consider the most important or interesting. This working draft aims to submit this content for publication around the beginning of 2025 in the yearly Tourette Syndrome Research Highlights series on F1000Research. The authors welcome article suggestions and thoughtful feedback from readers, who can add a comment by clicking on the rectangular comment box icon to the left of the LOG IN link at the top of this page. For private comments, you can reach us by email ( [email protected] or [email protected]).

Tracking The Evolving Role Of Artificial Intelligence In Implementation Science: Protocol For A Living Scoping Review Of Applications, Evaluation Approaches And Outcomes [Version 2; Peer Review: 2 Approved], Guillaume Fontaine, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: Artificial intelligence (AI) offers significant opportunities to improve the field of implementation science by supporting key activities such as evidence synthesis, contextual analysis, and decision-making to promote the adoption and sustainability of evidence-based practices. This living scoping review aims to: (1) map applications of AI in implementation research and practice; (2) identify evaluation approaches, reported outcomes, and potential risks; and (3) synthesize reported research gaps and opportunities for advancing the use of AI in implementation science.

METHODS: This scoping review will follow the Joanna Briggs Institute (JBI) methodology and the Cochrane guidance for living systematic reviews. A living scoping …

Computational Prediction Of Hemolysis In Laminar Non-Newtonian Fluid, Nasim Gholizadeh

Theses and Dissertations

Hemolysis, the rupture of red blood cells (RBCs), is a critical concern in blood-circulating devices, requiring accurate predictions to ensure patient safety. This study investigates the sensitivity of hemolysis predictions to variations in viscosity models and hemolysis coefficients under complex flow conditions. Computational Fluid Dynamics (CFD) simulations were conducted using Ansys Fluent and OpenFoam on identical meshes with the FDA benchmark nozzle model. Under laminar flow conditions, CFD frameworks accurately predicted global variables, but variations in derived quantities, such as strain rate and vorticity, emerged due to differences in numerical solvers and gradient evaluation methods. These variations affected predictions of …

Adhd Research And Practice: An Evaluation Of Psychologists’ Utilizations Of Adhd Assessments In Practice, Desiree Giesen

Theses and Dissertations

The incidence of first-time Attention-Deficit/Hyperactivity Disorder (ADHD) diagnoses among adults has been on the rise. There is limited research on effective practices for evaluating adult ADHD, with previous studies showing conflicting results regarding the effectiveness of various assessment measures. The current study investigates the assessment tools chosen by psychologists and their perceived importance in evaluating ADHD. A cross-sectional design was used with 200 participants who were primarily licensed psychologists. The unstructured clinical interview with the client was the most used assessment tool and was rated as having the highest importance, whereas continuous performance tasks were rated as having the lowest …

Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock

Theses and Dissertations

The introduction of Name, Image, and Likeness (NIL) regulations in collegiate athletics has created new financial and branding opportunities for student-athletes. Simultaneously, there has been an evolving legal landscape surrounding cannabinoids both at the state and National Collegiate Athletic Association (NCAA) levels. This dissertation in practice explores this emerging intersection by examining student-athlete perceptions of NIL opportunities with cannabinoid brands and highlighting the perceived advantages and disadvantages of such deals. This dissertation in practice consists of three artifacts. Artifact I provides essential background information on NIL, cannabinoids, and the House v. NCAA settlement. Recognizing the legal, institutional, and cultural shifts …

The Ability Of The Millon Pre-Adolescent Clinical Inventory (M-Paci) To Distinguish Between Adhd And Non-Adhd Clinical Groups, Michael Jowkar

Theses and Dissertations

The M-PACI is a personality scale based on Millon’s biosocial personality theory designed to measure emerging personality patterns in pre-adolescents (9-12 years old). There is minimal published research on this inventory, particularly in clinical contexts. For this study, we used a data set collected at a Midwestern private practice clinic where children are assessed for ADHD and learning disabilities. This study looks at how those diagnosed with ADHD differ in emerging personality patterns and current clinical signs scales compared to those in a clinical sample who have not been diagnosed with ADHD. Some studies have shown differences between children diagnosed …

Visible, Invisible: (Levantine) Arab American Men On Mental Health, Nesreen Jaber

Theses and Dissertations

To address the dearth in psychological research and practice in regards to Arab American men, this study examined the lived experiences of seven Levantine (Belad Al Sham) Arab American men with origins in Palestine, Lebanon, and Iraq. Semi-structured interviews, Interpretive Phenomenological Analysis (IPA), and a Liberation Psychology framework were utilized to explore their definitions of mental health, their experiences of stigma, their experiences with mental health therapy, and their attitudes towards psychology and therapy. A total of seven superordinate themes emerged that highlighted the roles of gendered stigma, cultural incongruence in therapeutic praxis, Eurocentric norms in psychology, and conceptualizations of …

An Intersectional Exploration And Analogue Investigation Of Transgender And Gender Diverse Bi+ Women’S Preferences For Sexual Violence Vulnerability Reduction Interventions, Sara K. Kuhn

Theses and Dissertations

Transgender and gender diverse (TGD) bisexual+ (bi+, e.g., pansexual, polysexual) women disproportionately experience sexual violence victimization and their acceptability of applicable interventions is under-researched. Online self-report data was collected from 240 ethnoracially diverse bi+ adult American women, who identified as TGD (n = 69) or cisgender (cis; n = 171), and who read standardized descriptions of interventions. TGD bi+ women found intervention descriptions inclusive of their sexual and gender identities—and those including in-person active resistance strategy instruction (bystander/self-defense)—more acceptable. Intervention descriptions with alcohol use and/or sexual activity reduction components were largely found to be less acceptable. Intervention elements of importance …

Strengthening Traffic Safety Laws On The Crow Indian Reservation, Darcy Merchant

Theses and Dissertations

The Crow Indian reservation is located in south-central Montana. The reservation is one of the largest land-based tribes in Montana, encompassing an area of over three thousand square miles. The reservation borders the state of Wyoming to the south and the Northern Cheyenne Indian reservation to the east. The reservation features a comprehensive transportation system that encompasses tribal, county, state, and federal roadways. Drivers and passengers who travel on these roadways are at higher risk for fatal and severe injury-related motor vehicle crashes than those in other reservations. This situation largely stems from the critical absence of targeted traffic safety …

Doctoral Student Mentoring: A Quantitative Analysis Of Faculty And Student Perceptions And Expectations, Laura Margaret Look

Theses and Dissertations

Doctoral student success is heavily influenced by the quality of mentoring and advising relationships with graduate faculty, yet doctoral student completion rates remain at a low rate of around 50%. The purpose of this quantitative study was to examine the mentoring relationships of doctoral students by surveying doctoral students and graduate faculty who mentor graduate students to identify their expectations for the mentor and mentee in the mentoring relationship. Data were collected from 155 students and 68 faculty in the spring 2024 semester at the University of North Dakota, a Midwest R2 institution. Nonparametric statistical analysis revealed several misalignments between …

Using Machine Learning To Investigate Weather Impacts On Crop Yield For Probabilistic, Climate-Informed Predictive Crop Breeding, Levi Newell

Theses and Dissertations

As the world’s population continues to grow, the importance of food security willonly continue to increase, with some estimates requiring a global increase in food production between 59 and 98% by 2050. The agriculture industry is also a crucial economic driver, with the industry supporting 20% of the state of North Dakota’s workforce, and with a total valuation of $41.3 billion. The economic importance of this industry and the challenges of future growth prompt a need for data driven decision making into the future, particularly with predictive crop breeding. This is the method by which crops are developed that are …

Extreme Environment Tribological Studies Of Multifunctional Materials, Matt Malusky

Theses and Dissertations

This research examines polymer wear behaviors across polyether-etherketone (PEEK) and polylactic acid (PLA) composites in varying environmental conditions. Tribological investigations of ceramic and intermetallic coatings are explored in the context of material selection for lunar operation. In the first study, PEEK composites incorporating ternary nanolaminate ceramics, termed MAB and MAX phases, were tested in varying temperature environments above and below their expected glass transition temperatures to evaluate their tribological performance in comparison to a non-reinforced PEEK substrate. Results showed that under ambient conditions, both MoAlB (MAB phase) and Cr2AlC (MAX phase) ceramics stabilize the friction coefficient compared to pure PEEK, …

Synthesis And Characterization Of Silicon-Containing Ternary Transition Metal Borides For High Performance Applications, Godswill Ngige

Theses and Dissertations

Binary borides are well known for their exceptional mechanical and thermal properties, including high strength, high melting points, outstanding hardness, and excellent chemical stability, making them suitable for high-temperature structural applications such as components in hypersonic vehicles, jet engines, nose cones, and the leading edges of aircraft. Despite these advantages, they are inherently brittle and suffer from low fracture toughness, limiting their ability to absorb impact or resist crack propagation.

To this end, attention shifted to ternary transition metal borides which are materials composed of a transition metal, boron, and a third element. These ternary compounds exhibit a broader range …

Which University Faculty Are Successful Researchers? Developing And Testing Measures Of Research Competence To Predict Faculty Research Motivation And Success, Muhammad Salahuddin

Theses and Dissertations

University faculty play a pivotal role in producing research that leads to positive social change through the creation of new knowledge, enhancement of higher education quality, and improved university rankings. Faculty produce more when they feel competent, autonomously motivated, and acknowledged. Past studies have measured faculty research competencies using self-report scales that may contain biases, potentially leading to significant discrepancies in research outcomes. My program of research – a three-article dissertation – aimed to develop and validate the test-based measures of faculty research competence that can more reliably predict faculty research success. The three studies provide an enhanced understanding of …

Chemical Looping As An Enabling Technology For Low-Carbon Energy Production, Junior Neguieh Domkam Nasah

Theses and Dissertations

Growth in global gross domestic product has historically been tied with high-carbon energy sources. Development of new low-carbon energy technologies is thus key to achieving a de-coupling of energy demand from economic growth. This dissertation evaluates the technical feasibility of a small-scale low-carbon solution referred to as Combined Hydrogen, Heat and Power (CH2P), a synthesis gas to hydrogen chemical looping process. The CH2P process is based on the steam-iron process and adopts multiple batch reactors to convert syngas in a two-step approach. First, the syngas is partially oxidized by reducing Magnetite (Fe3O4) to Wüstite (FeO) followed by complete oxidation in …

Mixed Method Case Study Of The Silver Program: Nohwi Báyáni Bidádadil’Įį - Watching Over Our Elder, Cameron Ray Smith

Theses and Dissertations

This program effects case study provides a comprehensive case review of Apache Behavioral Health Services (ABHS) Nohwi Báyáni Bidádadil’įį – Watching Over Our Elders (Silver Program). The research aims to understand the program’s effectiveness in identifying, addressing, and reducing Elder abuse/neglect/and exploitation. Assess how the program has used the Elder Abuse Suspicion Index (EASI), assess community partners and ABHS staff knowledge/familiarity with the program, and whether the Silver Program is effective.

To achieve the research aim, I reviewed four data sources: ABHS Electronic Health Record (EHR), ABHS internal survey, interviews with community partners, and artifact review of the Silver Program. …

From Theory To Practice: Addressing The Operational Challenges Of School Principals, Darin Murry Scherr

Theses and Dissertations

School principals play a crucial role in the effectiveness of educational institutions, yet many enter leadership positions lacking adequate preparation for operational responsibilities. This Dissertation in Practice examines the challenges principals face in managing financial, staffing, and facility operations and the impact of these challenges on principal retention. Using a qualitative multiple-case study approach, the research investigates the experiences of new and veteran principals within Bismarck Public Schools to identify gaps in their operational preparedness.Findings highlight five key themes: (1) gaps in financial and budgetary training, (2) the role of mentorship and support systems, (3) balancing instructional leadership with operational …

Advancing Human-Computer Interaction Systems Through Explainable And Secure Ai Integration, Ifiok Udoidiok

Theses and Dissertations

As artificial intelligence (AI) systems increasingly shape how humans interact with digital environments, the need for transparency, security, and robustness in intelligent decision making has become critical. This thesis explores how explainable and secure AI techniques can be integrated into modern human-computer interaction (HCI) systems to enhance trust, resilience, and alignment with human operators.

We present three related studies, each addressing a distinct challenge in the design of human-centered AI. First, we apply XAI methods, specifically Local Interpretable Model-Agnostic Explanations (LIME), to deep learning (DL) based CAPTCHA solvers. By interpreting model attention patterns, we uncover exploitable weaknesses in text CAPTCHA …