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Articles 275191 - 275220 of 5211109
Full-Text Articles in Entire DC Network
Concurrent Occurrence Of A Salivary Duct Cyst And Two Mucoceles In The Lower Lip, An-Ni Shih, Ying-Tai Jin, Andy Sun, Chun-Pin Chiang
Concurrent Occurrence Of A Salivary Duct Cyst And Two Mucoceles In The Lower Lip, An-Ni Shih, Ying-Tai Jin, Andy Sun, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
A Multi-Participation Model Of Oral Health Care For The Students At The Outlying Island Schools: A Case Study Of Kinmen County Jin-Hu Junior High School, Feng-Chou Cheng, Kung-Chieh Wu, Ming-Chung Lee, Chun-Pin Chiang
A Multi-Participation Model Of Oral Health Care For The Students At The Outlying Island Schools: A Case Study Of Kinmen County Jin-Hu Junior High School, Feng-Chou Cheng, Kung-Chieh Wu, Ming-Chung Lee, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
The Dental Clinic On The Postcard With The Theme Of Taiwan Street Scene During The Japanese Colonial Period: The Story Of A Japanese Immigrant, Dr. Akira Sugiyama, Feng-Chou Cheng, Ling-Hsia Wang, Chun-Pin Chiang
The Dental Clinic On The Postcard With The Theme Of Taiwan Street Scene During The Japanese Colonial Period: The Story Of A Japanese Immigrant, Dr. Akira Sugiyama, Feng-Chou Cheng, Ling-Hsia Wang, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
Ethical Implications And Moral Considerations Of Dental Practice Based On Taiwan's Medical Regulations, Feng-Chou Cheng, Wei-Chun Lin, Ling-Hsia Wang, Chun-Pin Chiang
Ethical Implications And Moral Considerations Of Dental Practice Based On Taiwan's Medical Regulations, Feng-Chou Cheng, Wei-Chun Lin, Ling-Hsia Wang, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
Severe External Root Resorption Of The Right Maxillary Second Molar Caused By The Pressure From An Impacted Wisdom Tooth, Feng-Chou Cheng, Yu-Ting Hu, Chun-Pin Chiang
Severe External Root Resorption Of The Right Maxillary Second Molar Caused By The Pressure From An Impacted Wisdom Tooth, Feng-Chou Cheng, Yu-Ting Hu, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, And Gastric Parietal Cell Antibody Positivity In Oral Lichen Planus Patients With Or Without Microcytosis, Chung-Pin Chiang, Yi-Pang Lee, Ying-Tai Jin, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun
Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, And Gastric Parietal Cell Antibody Positivity In Oral Lichen Planus Patients With Or Without Microcytosis, Chung-Pin Chiang, Yi-Pang Lee, Ying-Tai Jin, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun
Journal of Dental Sciences
Abstract Background/purpose Microcytosis is defined as having mean corpuscular volume (MCV) < 80 fL. This study evaluated whether 78 oral lichen planus (OLP) patients with microcytosis (microcytosis/OLP patients) and 510 OLP patients without microcytosis (non-microcytosis/OLP patients) had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects. Materials and methods Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 78 microcytosis/OLP patients, 510 non-microcytosis/OLP patients, and 588 healthy control subjects were measured and compared. Results We found that 71.8 %, 46.2 %, 10.3 %, 0.0 %, 18.0 %, and 20.5 % of 78 microcytosis/OLP patients and 18.0 %, 12.4 %, 10.2 %, 1.4 %, 21.6 %, and 24.1 % of 510 non-microcytosis/OLP patients had blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all P -values <0.001). Moreover, 78 microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients. Conclusion We conclude that our 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients have significantly higher frequencies of anemia, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects. Moreover, 78 microcytosis/OLP patients also have significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.
2-O-Methylmagnolol Mitigates The Generation Of Reactive Oxidative Stress And Inflammaging In Human Gingival Epithelial Cells And Fibroblasts With Advanced Glycation End Products Stimulation, Yu-Chao Chang, Liang-Gie Huang, Cheng-Chia Yu, Jia-You Fang, Min Ng, Yi-Wen Liao
2-O-Methylmagnolol Mitigates The Generation Of Reactive Oxidative Stress And Inflammaging In Human Gingival Epithelial Cells And Fibroblasts With Advanced Glycation End Products Stimulation, Yu-Chao Chang, Liang-Gie Huang, Cheng-Chia Yu, Jia-You Fang, Min Ng, Yi-Wen Liao
Journal of Dental Sciences
Abstract Background/purpose Individuals with diabetes mellitus (DM) are more susceptible to periodontitis, largely due to the accumulation of advanced glycation end-products (AGEs), which drive oxidative stress and inflammaging. Inflammaging is a state of chronic low-grade inflammation and accelerated cellular aging that contributes to periodontal degradation, mediated by AGEs-induced cellular senescence and senescence-associated secretory phenotype (SASP). 2-O-methylmagnolol (2-MG), a bioactive compound with antioxidant and anti-inflammatory properties, remains underexplored in DM-associated periodontal degeneration. This study investigated the effects of 2-MG on AGE-induced oxidative stress and inflammaging in human gingival epithelial cells (HGEs) and human gingival fibroblasts (HGFs). Materials and methods The study …
Classification Of Immediate Implant Placement (Iip) And Immediate Implant Placement With Provisionalization (Iipp) Based On The Scores Of Surgical And Restorative Difficulties, Je-Kang Du, Chiun-Lin Steven Liu, Ching-Jung Chang Chien
Classification Of Immediate Implant Placement (Iip) And Immediate Implant Placement With Provisionalization (Iipp) Based On The Scores Of Surgical And Restorative Difficulties, Je-Kang Du, Chiun-Lin Steven Liu, Ching-Jung Chang Chien
Journal of Dental Sciences
Abstract Background/purpose Immediate implant placement (IIP) and immediate implant placement with provisionalization (IIPP) have gained popularity for reducing treatment time and improving patient outcomes. However, these techniques involve varying levels of surgical and prosthetic complexity. Existing implant classification systems primarily focus on timing and bone healing stages, but they do not fully address the combined surgical and restorative challenges presented by IIP and IIPP cases. The purpose of this article was to provide a classification system for IIP and IIPP based on their surgical and restorative difficulties. Materials and methods This retrospective clinical study evaluated immediate implant placement (IIP) and …
Psychosomatic Concepts In Nociplastic Pain: The Case Of Burning Mouth Syndrome, Takayuki Suga, Akira Toyofuku
Psychosomatic Concepts In Nociplastic Pain: The Case Of Burning Mouth Syndrome, Takayuki Suga, Akira Toyofuku
Journal of Dental Sciences
No abstract provided.
Adenomatoid Odontogenic Tumor Arising From A Dentigerous Cyst In An Elderly Patient: An Unusual Presentation, Kyu-Young Oh
Adenomatoid Odontogenic Tumor Arising From A Dentigerous Cyst In An Elderly Patient: An Unusual Presentation, Kyu-Young Oh
Journal of Dental Sciences
No abstract provided.
Screening For Levels Of Social Difficulties And Unemployment In Head And Neck Cancer Patients By University Of Washington Quality Of Life Questionnaire (Uw-Qol): Current Status And Cut-Off Point Establishment, Yeur-Hur Lai, Min-Ru Chen, Yuan-Yuan Fang, Yen-Ju Chen, Pei-Jen Lou, Cheng-Ping Wang, Jenq-Yuh Ko, Shu‑Ching Chen, Yun-Hsiang Lee
Screening For Levels Of Social Difficulties And Unemployment In Head And Neck Cancer Patients By University Of Washington Quality Of Life Questionnaire (Uw-Qol): Current Status And Cut-Off Point Establishment, Yeur-Hur Lai, Min-Ru Chen, Yuan-Yuan Fang, Yen-Ju Chen, Pei-Jen Lou, Cheng-Ping Wang, Jenq-Yuh Ko, Shu‑Ching Chen, Yun-Hsiang Lee
Journal of Dental Sciences
Abstract Background/purpose Social function and employment are vital to the quality of life in head and neck cancer (HNC) survivors. This study aimed to (1) assess the status of social difficulties (including getting along with others, social participation and unemployment); (2) examine their associations with the University of Washington Quality of Life Questionnaire (UW-QOL); and (3) establish UW-QOL cut-off points for identifying social difficulties after primary treatment. Materials and methods The cross-sectional study was conducted at a medical center in Taiwan, involving HNC survivors under 65 years who completed primary treatments. Data collection included the UW-QOL, the “getting along” and …
Digital Transformation And Talent Needs In The Greater China Region: Additional Perspectives From Mainland China, Hongnan Ye
Journal of Dental Sciences
No abstract provided.
Adenoid Ameloblastoma In The Maxilla, Yu-Min Lin, Yuk-Kwan Chen, Wen-Chen Wang, Chih-Huang Tseng
Adenoid Ameloblastoma In The Maxilla, Yu-Min Lin, Yuk-Kwan Chen, Wen-Chen Wang, Chih-Huang Tseng
Journal of Dental Sciences
No abstract provided.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging Of Masticatory Muscles In Patients With Idiopathic Condylar Resorption, Yu-Chen Wang, Hsiao-Chiao Yeh, Yunn-Jy Chen, Tiffany Ting-Fang Shih
Dynamic Contrast-Enhanced Magnetic Resonance Imaging Of Masticatory Muscles In Patients With Idiopathic Condylar Resorption, Yu-Chen Wang, Hsiao-Chiao Yeh, Yunn-Jy Chen, Tiffany Ting-Fang Shih
Journal of Dental Sciences
Abstract Background/purpose Idiopathic condylar resorption (ICR), a subset of temporomandibular disorders (TMDs), presents an unclear relationship between structural changes in the mandibular condyle and alterations in masticatory muscle perfusion. This study aimed to investigate the correlation between mandibular condyle structural changes and masticatory muscle perfusion in patients with ICR using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Materials and methods From July 2018 to August 2022, patients with ICR from hospital-based TMD clinics underwent conventional and DCE MRI examinations. The patients were categorized on the basis of the degree of temporomandibular joint (TMJ) condylar resorption into grade 0 (normal), grade …
Evaluating Dentinal Crack Formation After Root Canal Preparation Using Nickel-Titanium Rotary File Systems, Kaveh Nasiri, Karl-Thomas Wrbas
Evaluating Dentinal Crack Formation After Root Canal Preparation Using Nickel-Titanium Rotary File Systems, Kaveh Nasiri, Karl-Thomas Wrbas
Journal of Dental Sciences
No abstract provided.
Novel Radiographic Pattern Of Maxillary Periostitis Induced By Endodontic Inflammation: A Case Report, Pai-Chun Huang, I-Hao Su, Meng-Ling Chiang, Jyh-Kwei Chen
Novel Radiographic Pattern Of Maxillary Periostitis Induced By Endodontic Inflammation: A Case Report, Pai-Chun Huang, I-Hao Su, Meng-Ling Chiang, Jyh-Kwei Chen
Journal of Dental Sciences
No abstract provided.
Managing Limited Clinical Crown Height With Vital Pulp Therapy: Clinical Application And Outcome, Sheila May Lao Dee, Chun Yi Kao, Arturo P. De Leon, Tsui Hsien Huang
Managing Limited Clinical Crown Height With Vital Pulp Therapy: Clinical Application And Outcome, Sheila May Lao Dee, Chun Yi Kao, Arturo P. De Leon, Tsui Hsien Huang
Journal of Dental Sciences
No abstract provided.
Masson's Tumor Of Masticatory Space: Detection In Medical Images, Pei-Ju Chiang, Yang-Che Wu, Kazuyo Kuribayashi Sato, Chun-Yu Ho
Masson's Tumor Of Masticatory Space: Detection In Medical Images, Pei-Ju Chiang, Yang-Che Wu, Kazuyo Kuribayashi Sato, Chun-Yu Ho
Journal of Dental Sciences
No abstract provided.
Exploring The Correlation Between Dental Procedures And Trigemino-Cardiac Reflex, Chun-Pin Lin, Tsao-Li Chuang, Yu-Ting Li, Tai-Wei Feng, Hao-Hueng Chang
Exploring The Correlation Between Dental Procedures And Trigemino-Cardiac Reflex, Chun-Pin Lin, Tsao-Li Chuang, Yu-Ting Li, Tai-Wei Feng, Hao-Hueng Chang
Journal of Dental Sciences
Abstract Background /purpose: The trigemino-cardiac reflex (TCR) is a brainstem reflex characterized by sudden reductions in heart rate (HR) and mean arterial blood pressure (MABP) following trigeminal nerve stimulation. Although well-documented in other surgical fields, its role during dental procedures remains unclear. This study examined the association between routine dental interventions and TCR using an experimental animal model. Materials and methods This study presented a comprehensive analysis of physiological monitoring data obtained during a series of animal experimental surgeries conducted by our research team between 2016 and 2023. Changes in HR and MABP during routine dental procedures were evaluated using …
A Novel Combined Implantoplasty And Regenerative Surgical Approach To Salvage Implants: A Report On Two 20-Year-Old Implants, Shing-Zeng Dung
A Novel Combined Implantoplasty And Regenerative Surgical Approach To Salvage Implants: A Report On Two 20-Year-Old Implants, Shing-Zeng Dung
Journal of Dental Sciences
No abstract provided.
Exploring Gender-Specific Prognostic Factors And Survival Outcomes In Oral Squamous Cell Carcinoma: Insights From A Taiwanese Cohort, Shih-Jung Cheng, Hui-Hsin Ko, Fang-Yu Wu, Hsiang-Fong Kao, Wender Lin, Ya-Syuan Chen
Exploring Gender-Specific Prognostic Factors And Survival Outcomes In Oral Squamous Cell Carcinoma: Insights From A Taiwanese Cohort, Shih-Jung Cheng, Hui-Hsin Ko, Fang-Yu Wu, Hsiang-Fong Kao, Wender Lin, Ya-Syuan Chen
Journal of Dental Sciences
Abstract Background /purpose: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in Taiwan, with sex-specific variations in risk factors, clinical presentation, and prognosis. This study aimed to evaluate the clinicopathological characteristics and survival outcomes of a larger cohort of male and female OSCC patients treated at National Taiwan University Hospital (NTUH) between 2012 and 2022. Materials and methods A retrospective review of 240 de-identified, sex- and age-matched OSCC patients was conducted, analyzing clinicopathological characteristics, lifestyle habits (alcohol, betel quid, smoking), and survival outcomes. Results Gender differences were observed in tumor location, with males more likely to have buccal mucosa …
The Standardization Of Oral Health Screening Survey In Taiwan, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
The Standardization Of Oral Health Screening Survey In Taiwan, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
Journal of Dental Sciences
No abstract provided.
Fatostatin Delayed Lip Sensory Recovery After Inferior Alveolar Nerve Transection By Inhibiting Sterol Regulatory Element-Binding Protein 1, Li Ye, Suning Mao, Zhongkai Ma, Gaowei Zhang, Pingchuan Ma, Chunjie Li
Fatostatin Delayed Lip Sensory Recovery After Inferior Alveolar Nerve Transection By Inhibiting Sterol Regulatory Element-Binding Protein 1, Li Ye, Suning Mao, Zhongkai Ma, Gaowei Zhang, Pingchuan Ma, Chunjie Li
Journal of Dental Sciences
Abstract Lipid metabolism is essential for nerve repair in damaged nerves. Fatostatin, a selective inhibitor of sterol regulatory element-binding protein 1 (SREBP1), could reduce cholesterol synthesis and disturb lipid homeostasis. However, whether fatostatin would delay lip sensory recovery after inferior alveolar nerve transection remains unclear. In this preliminary study, we investigated the effects of fatostatin on lip sensory recovery in vivo and axon growth in vitro . Fatostatin significantly delayed lip sensory recovery of mice after inferior alveolar nerve transection as evidenced by quantitative sensory testing. Fatostatin also reduced the average axon length of primary trigeminal neurons. Despite SREBP1, expressions …
Investigating The Relation Among The Needle Insertion Plane, Occlusal Plane, Mandibular Foramen, And Mandibular Lingula For Inferior Alveolar Nerve Block, Han-Sheng Chen, Kun-Jung Hsu, Pei-Jung Chen, Hui-Na Lee, Jen Hao Chen, Chun-Ming Chen
Investigating The Relation Among The Needle Insertion Plane, Occlusal Plane, Mandibular Foramen, And Mandibular Lingula For Inferior Alveolar Nerve Block, Han-Sheng Chen, Kun-Jung Hsu, Pei-Jung Chen, Hui-Na Lee, Jen Hao Chen, Chun-Ming Chen
Journal of Dental Sciences
Abstract Background/purpose The success rates and incidence of positive blood aspiration during inferior alveolar nerve blocks (IANB) vary. Understanding the relative positions of the mandibular foramen (MF), mandibular lingula (ML), and occlusal plane (OP) is crucial for the effectiveness and safety of IANB. This study evaluates the relationship among needle insertion levels, ML, and OP for IANB. Materials and methods Cone-beam computed tomography images of 90 participants were analyzed to measure ML and MF distances relative to OP. Participants were categorized into skeletal classes (I, II, and III). The distances from ML to the anesthetic needle positioned 5, 6, 7, …
Effects Of Various Aging Modes On The Optical Properties Of Zirconia With Different Yttria Concentrations In Coffee And Tea, Wei-Chun Lin, Chih-Wei Tseng, Chenmin Yao, Liang-Yu Wei, Pei-Wen Peng
Effects Of Various Aging Modes On The Optical Properties Of Zirconia With Different Yttria Concentrations In Coffee And Tea, Wei-Chun Lin, Chih-Wei Tseng, Chenmin Yao, Liang-Yu Wei, Pei-Wen Peng
Journal of Dental Sciences
Abstract Background/purpose The esthetic performance of dental zirconia may be affected by both material composition and environmental exposure. This study aimed to evaluate how different aging conditions-hydrothermal aging and thermal cycling-influenced the optical properties of dental zirconia containing varying yttria concentrations (3Y-TZP, 4Y-TZP, and 5Y-TZP) in coffee and tea. Materials and methods A total of 120 zirconia specimens were prepared using three yttria concentrations. Each group was subjected to four artificial aging conditions: storage in coffee or tea at 37 °C for 1 and 6 months (hydrothermal aging), or 10,000 and 50,000 cycles of thermal cycling between 5 °C and …
Ubiquitin-Like With Phd And Ring Finger Domains 1 As A Potential Therapeutic Target In Smoking-Associated Oral Squamous Cell Carcinoma, Yi-Shing Shieh, Jia-Rong Wu, Che-Ting Yeh, Chu-Yen Chien, Ying-Chen Chen, Tsai-Wang Huang, Che-Yi Lin, Alexander Cheng-Ting Hsieh, Yi-Jen Hung
Ubiquitin-Like With Phd And Ring Finger Domains 1 As A Potential Therapeutic Target In Smoking-Associated Oral Squamous Cell Carcinoma, Yi-Shing Shieh, Jia-Rong Wu, Che-Ting Yeh, Chu-Yen Chien, Ying-Chen Chen, Tsai-Wang Huang, Che-Yi Lin, Alexander Cheng-Ting Hsieh, Yi-Jen Hung
Journal of Dental Sciences
Abstract Background/purpose Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy with poor clinical outcomes. Epigenetic dysregulation, particularly involving the ubiquitin-like with phd and ring finger domains 1 (UHRF1), is increasingly recognized in cancer progression. However, the role of UHRF1 in OSCC and its regulation by cigarette smoking remains unclear. Therefore, the aim of this study was to investigate whether cigarette smoking influences UHRF1 expression in OSCC. Materials and methods UHRF1 expression was analyzed in OSCC tissues using publicly available Gene Expression Omnibus (GEO) datasets. Quantitative PCR and western blotting were employed to evaluate UHRF1 levels in OSCC …
The Postal Life Insurance Including Dental Services In Taiwan During The Japanese Colonial Period, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
The Postal Life Insurance Including Dental Services In Taiwan During The Japanese Colonial Period, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
Journal of Dental Sciences
No abstract provided.
Stomatology From The Popular Science Reading Materials Of The Late Qing Dynasty Imperial Family: Oral Anatomical Diagrams In The Li Ke Guatu (Illustrations Of The Sciences), Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
Stomatology From The Popular Science Reading Materials Of The Late Qing Dynasty Imperial Family: Oral Anatomical Diagrams In The Li Ke Guatu (Illustrations Of The Sciences), Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
Journal of Dental Sciences
No abstract provided.
Gas5 Decreased The Arecoline-Induced Myofibroblasts Activity In Buccal Mucosal Fibroblasts Via Acting As A Competing Endogenous Rna For Mir-21, Chuan-Hang Yu, Heng-Yi Liao, Jung-Chun Yeh, Shih-Min Wang, Ming-Yi Lu, Yi-Wen Liao, Cheng-Chia Yu, Fu-Chen Lin
Gas5 Decreased The Arecoline-Induced Myofibroblasts Activity In Buccal Mucosal Fibroblasts Via Acting As A Competing Endogenous Rna For Mir-21, Chuan-Hang Yu, Heng-Yi Liao, Jung-Chun Yeh, Shih-Min Wang, Ming-Yi Lu, Yi-Wen Liao, Cheng-Chia Yu, Fu-Chen Lin
Journal of Dental Sciences
Abstract Background/purpose Oral submucous fibrosis (OSF) is recognized as a premalignant condition that increases the risk of oral cancer. Myofibroblasts are the primary cellular mediators of the pathological fibrosis characteristic of OSF. Consequently, understanding the molecular mechanisms that drive myofibroblast activation is crucial for the development of effective therapeutic interventions for this condition. Growth arrest-specific 5 (GAS5), a long non-coding RNA, represents a potential regulatory factor in OSF pathogenesis, although its specific role remains largely undefined. Materials and methods To validate the direct interaction between GAS5 and its target miR-21, a luciferase reporter assay was performed. qRT-PCR was employed to …
Full-Length 16s Rrna Sequencing Reveals Microbial Characteristics In Supragingival Plaque Of Periodontitis Patients, Wei-Jen Chang, Chih-Chieh Wen, Jerry C.-Y. Lin, Eisner Salamanca, Nai-Chia Teng, Yi-Jen Lin, Yi-Fan Wu, Hung-Ming Chang
Full-Length 16s Rrna Sequencing Reveals Microbial Characteristics In Supragingival Plaque Of Periodontitis Patients, Wei-Jen Chang, Chih-Chieh Wen, Jerry C.-Y. Lin, Eisner Salamanca, Nai-Chia Teng, Yi-Jen Lin, Yi-Fan Wu, Hung-Ming Chang
Journal of Dental Sciences
Abstract Background/Purpose Periodontitis is a chronic inflammatory disease that disrupts oral microbial homeostasis and contributes to systemic inflammation. While previous studies have focused on subgingival microbiota, the role of supragingival plaque as an early microbial reservoir remains underexplored. Most previous studies have relied on short-read 16S rRNA sequencing but limited detailed classification. This study uses Third-Generation Sequencing (TGS) with full-length 16S rRNA sequencing and DADA2-based error correction to better characterize the supragingival microbiome in periodontitis. Materials and methods A total of 30 participants (15 periodontitis patients and 15 healthy controls) were recruited. Supragingival plaque samples were collected, and full-length 16S …