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Comparison Of Four Modified Methods Of Ligation Induction Of Periodontitis In Wistar Rat Model: A Pilot Study, Rio Simanjuntak, Budi, Pitu Wulandari, Martina Amalia, Denny Satria

Journal of Dentomaxillofacial Science

No abstract provided.

The Effectivity Of The Combination Of Tricalcium Silicate Cement And Galam Leaf Extract (Melaleuca Cajuputi Subsp. Barlow) As Direct Pulp Capping Materials Reviewed From Vegf, Fgf-2, And Tgf-Β: A Systematic Review, Sherli Diana, Irene E. Rieuwpassa, Juni J. Nugroho, Rasmidar Samad, Risfah Yulianty, Nurhayaty Natsir

Journal of Dentomaxillofacial Science

No abstract provided.

Piladang (Solenostemon Scutellarioides (L.) Codd) Leaf Ethanolic Extract Increases Growth Factors In Chronic Periodontitis Rat Models, Christiana C. Prihastuti, Agatha T. Purnamasari, Irma Khoerunisa, Amilia Ramadhani, Nuryanti, Tuti S. Suhesti

Journal of Dentomaxillofacial Science

No abstract provided.

Effectiveness Of Gelatin Extracted From Mackerel Bone (Rastrelliger Sp) On Cell Count In Wistar Rats Mandibular Bone Healing-In Vivo, Isnandar, Gostry A. Dohude, Hendry Rusdy, Muhammad F. Lubis, Lokot D. Lubis, Kevin Marpaung, Monica L. Romauli, Aulia I. Sari

Journal of Dentomaxillofacial Science

No abstract provided.

Treatment Adherence, Self-Esteem And Employment Challenges Among Young Adults With Cleft Lip And Palate: A Multi-Centre Study In Malaysia, Murshida M. Nor, Thum Chen, Pow K. Jun, Haslina Rani, Suziyani Mohamed, Khairil Am. Khan, Syed Ns. Omar, Rozita Hassan, Tuti N. Mohd-Dom

Journal of Dentomaxillofacial Science

No abstract provided.

Special Needs Dentistry Knowledge, Perceptions, And Training Needs Among Dentists From Generation X, Y, Z, And Baby Boomer In Indonesia, Nadia Kartikasari, Ratri M. Sitalaksmi, David Aldrian, Aisyah Rp. Gofur, Mas S. Ahmad

Journal of Dentomaxillofacial Science

No abstract provided.

The Effect Of Toothpaste Containing Uncaria Gambir Roxb. Extract In Oral Health, Siti Rp. Dewi, Clarissa I. Arif, Aquila H. Tuzzahra, Pudji Handayani

Journal of Dentomaxillofacial Science

No abstract provided.

The Potential Of Oral Cavity Bacterial Relative Abundance Index For Determining The Severity Of Dental Caries, Masyhudi, Krishna P. Candra, Esti H. Hardi, Aman S. Panggabean, Islamuddin Ahmad, Hadi Kuncoro, Rudy A. Nugroho

Journal of Dentomaxillofacial Science

No abstract provided.

Camouflage Treatment Of Skeletal Class Iii Malocclusion: A Case Report, Ida B. Narmada, Fidiyah Inayati, Nabilla Vr. Prasetyo, Gemelli N. Illahi, Audwin R. Nugroho

Journal of Dentomaxillofacial Science

No abstract provided.

Surgical Correction Of Multiple Malunion Fracture In The Mandible: A Case Report, Vera Julia, Amirul I. Hiroshi, Arbi Wijaya, Ditha Noviantika, A. Surya Darma

Journal of Dentomaxillofacial Science

No abstract provided.

Navigating Challenges In Dentomaxillofacial Science By Integrating Genetics, Clinical Innovation, And Educational Intervention: Editorial Review, H. Hasanuddin, Acing H. Mude, Muhammad Ikbal, Erni Marlina, Muhammad Ruslin

Journal of Dentomaxillofacial Science

No abstract provided.

Comparison Of In Situ Plant Area Index And Remotely Sensed Leaf Area Index Of Northeastern American Deciduous, Mixed, And Coniferous Forests For Smapvex19-22, Christopher Cook, Laura Bourgeau-Chavez, Dorthea Vander Bilt, Mary E. Miller, Simon Kraatz, Michael H. Cosh, Victoria R. Kelly, Andreas Colliander

Michigan Tech Publications

Leaf Area Index (LAI) and Plant Area Index (PAI) are critical biophysical parameters for quantifying foliage density of crops and trees. As such they may also be effective metrics to estimate the impact of leafy vegetation on microwave signals, like the radiometer on board NASA’s Soil Moisture Active Passive (SMAP) satellite. This study presents a comprehensive analysis of PAI and LAI measurements acquired through in situ and remotely sensed (RS) methods in diverse forest ecosystems of northeastern America, including deciduous, mixed, and coniferous forests. We compare RS LAI and ground-truth PAI data to understand the variation between the RS LAI …

Pygoscelis Penguins Prefer Different Oceanographic And Terrestrial Habitats During The Austral Summer, Katherine L. Gallagher, Rachel Herman, Katherine Walton, Michael S. Dinniman, Heather J. Lynch

OES Faculty Publications

Pygoscelis penguins interact with both terrestrial and marine environments, especially during the austral summer when they raise their chicks. Accessible ice-free ground spaces serve as locations for penguins to build colonies and successfully raise chicks while the surrounding marine environment serves as the foraging grounds for adult birds. Penguins must be able to navigate through the waters around their colonies to forage for Antarctic krill (Euphausia superba), their primary prey during the austral summer. Krill, whose distributions are driven partially by the surrounding physics and partially by their behaviors, must also be plentiful in the waters near the …

Evidence Of Mineral Alteration In A Salt Marsh Subterranean Estuary: Implications For Carbon And Trace Element Cycling, J. J. Tamborski, M. J. Eagle, M. T. Thorpe, M. A. Charette, B. L. Kurylyk, S. Rahman, K. D. Kroeger, J. O'Keefe Suttles, A. G. Mann, T. W. Brooks, Z. A. Wang

OES Faculty Publications

Subterranean estuaries (STE) in salt marshes are biogeochemically active zones where interactions between terrestrial groundwater and seawater drive complex cycling of carbon and trace elements, influenced by mineral dissolution. These systems, characterized by fine-grained organic-rich peat overlying permeable coastal aquifers, play a crucial role as a blue carbon sink, yet their geochemical dynamics remain poorly understood. We investigated dissolved trace elements, carbon, silica, and radium isotopes in a salt marsh STE (Sage Lot Pond, Waquoit Bay, MA) over seasonal and annual cycles. Our results reveal that groundwater and estuarine water circulation through marsh peat and aquifer sediments leads to enrichments …

Investigating The Human Face Processing Network: Insights From Acquired Prosopagnosia And Hyperfamiliarity For Faces, Marie-Luise Kieseler

Dartmouth College Ph.D Dissertations

Human faces provide essential social cues that we interpret rapidly, allowing us to recognize identities, interpret emotions, and gauge familiarity. This thesis explores face processing disruptions in four case studies, each offering new insights into the brain’s face recognition mechanisms.

Chapter one presents Annie, a 28-year-old woman who acquired prosopagnosia (face blindness) following COVID-19. After recovering from the severe symptoms of the infection, Annie experienced significant difficulty in recognizing familiar faces and navigating familiar environments. Testing confirmed her impairment in face recognition but showed her preserved cognitive and basic visual processing abilities. Annie was still able to recognize objects and …

Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells, Amanda I. Ya

Dartmouth College Ph.D Dissertations

Aberrant mitotic chromosome segregation results in the generation of cells with aneuploidy, an incorrect number of chromosomes. Aneuploidy can compromise the viability of the developing embryo and is the leading cause of pregnancy loss, failed embryo implantation, and congenital birth defects. Yet, widescale analysis of human embryos from in vitro fertilization (IVF) clinics suggests that aneuploidy is common, with upwards of 70% of preimplantation embryos being aneuploid.

Mitotic chromosome missegregation during post-zygotic development results in mosaic embryos made up of both diploid and aneuploid cells. Strikingly, upon transplant for pregnancy, mosaic embryos have been reported to result in healthy birth …

Polarimetric Capture And Differentiable Rendering, Katherine Anne Salesin

Dartmouth College Ph.D Dissertations

Many scientific fields rely on the capture and modeling of light to extract underlying information about the world. Often, more information can be extracted by capturing more about the nature of the light, such as its spectral shape or polarization state. While polarization is a relatively unexplored topic in computer graphics, when used in tandem with other recent advancements in the field it has enormous potential to improve both forward and inverse models in other scientific disciplines. We demonstrate this potential in two distinct settings in this thesis.

First, we apply the capture of polarized light to an inverse problem …

Application-Driven Materials Development Of Solid-State Conductive Composites Of Ultra-High Molecular Weight Polyethylene, Peder Solberg

Dartmouth College Ph.D Dissertations

Ultra-high molecular weight polyethylene (UHMWPE) is a linear long chain homopolymer valued for its toughness, wear resistance, and chemical inertness. In the medical field, these properties make it the material of choice for bearing surfaces despite recognized tradeoffs between wear resistance, toughness, and oxidation resistance. Electrically conductive composites of UHMWPE show promise to enable new types of smart and active load-bearing implants in a future of personalized medicine, if beneficial properties can be maintained with the addition of solid-state additives.

Clinical need-finding conducted through Dartmouth’s Training Program in Surgical Innovation revealed several potential applications for conductive, load-bearing polymers. These include: …

A Virus Of The Mind: The Neurological Impact Of Neonatal Herpes Simplex Virus Infection, Abigail Jeanne Dutton

Dartmouth College Ph.D Dissertations

The ability of herpes simplex virus (HSV) to establish lifelong latency in sensory neurons makes it one of the most pervasive viruses worldwide. Although most HSV infections are asymptomatic or cause limited cutaneous symptoms, some give rise to serious central nervous system (CNS) manifestations. Both primary HSV infection and subsequent reactivation events can cause viral replication and spread within the brain, ultimately leading to pathologic inflammation and direct CNS damage. In addition to fulminant presentations of HSV encephalitis, subclinical HSV CNS infections have been implicated in neurodevelopmental, cognitive, and neurodegenerative impairment. To model the lifelong effects of subclinical HSV infection, …

Design And Manufacturing Of Multifunctional Piezoelectric Composites, Huan Zhao

Dartmouth College Ph.D Dissertations

Piezoelectric materials possess a unique ability to convert mechanical energy into electrical signals and have broad industrial applications. However, monolithic piezoelectric materials such as piezoceramics and piezopolymers often suffer from inherent trade-offs among mechanical strength, elasticity, and durability. Piezoelectric composites, typically consisting of a polymer matrix with ceramic reinforcements, offer a solution by combining the advantages of each constituent. Nevertheless, maintaining stable mechanical performance in high-temperature environments remains a significant challenge as conventional polymer matrices usually experience structural degradation.

In this thesis, a novel piezoelectric composite is developed using a preceramic polymer (PCP) matrix with barium titanate (BTO) inclusions. PCPs …

Multimodal Machine Learning To Enhance Patient Prognosis & Management In Cancer Care, Peiying Hua Phd

Dartmouth College Ph.D Dissertations

Precision medicine is a data-driven approach that tailors treatments to individualized need. Emerging in the late twentieth century, it emphasizes customizing therapy based on each person’s unique characteristics and became a major national focus in the US starting in 2015.

Cancer remains a leading cause of death worldwide. With high mortality rates and resource- intensive treatment process, it burdens the healthcare systems. One of the inherent challenges in cancer care is its biological heterogeneity, making diagnosis and treatment planning highly complex and calls for personalized cancer management.

Today, diverse data sources are available to support cancer management and treatment decisions. …

Of Mice And Men: The Regulation Of Herpes Simplex Virus 1 Latency In Mouse And Human Neurons, Paige N. Canova

Dartmouth College Ph.D Dissertations

Herpes simplex virus 1 (HSV-1) establishes latent infections in sensory neurons, from which HSV sporadically reactivates, often due to external stress and other stimuli. Latency and reactivation are commonly studied using in vivo and ex vivo models in a variety of hosts, as well as in vitro models including primary mouse neurons and neurons derived from human pluripotent stem cells (iPSCs). The criteria for authentically modeling HSV latency include the ability to easily manipulate host genetics and biological pathways, as well as mimicking the immune response and viral pathogenesis in human infections. Presently, there remains a pressing need for …

Potsdam: Pareto Optimization Targeting Security, Data, And Mediation, J Peter Brady

Dartmouth College Ph.D Dissertations

Given the growing amount and variety of data handled by modern systems, it is crucial to guarantee the accuracy and protection of input data without errors or malicious intentions. The need to improve security in software programs often conflicts with the assurance of maximum performance, making developers and maintainers hesitant to incorporate more testing.

LangSec (Language-Theoretic Security) is a security approach that treats input validation as a formal language recognition problem, ensuring that only well-defined, unambiguous inputs are processed to eliminate exploitable parsing flaws. This dissertation explores integrating LangSec principles with Pareto optimization to enhance safety and robustness in digital …

Leveraging Epigenomics And Transcriptomics To Develop High-Dimensional Biomarkers Of Neuroinflammation, Steven C. Pike

Dartmouth College Ph.D Dissertations

Neuroinflammation is a critical physiological phenomenon implicated in most neurological disorders, either as a cause or a consequence of pathology. Our understanding of neuroinflammation is limited by the inability to directly profile the cells of interest. Thus, developing biomarkers of neuroinflammation is clinically urgent as we know neuroinflammation correlates with patient outcomes and treatment success. The recent advances in “omics” technologies, particularly epigenomics and transcriptomics, provides the opportunity for high-dimensional profiling of biospecimens for potential biomarkers. Within this dissertation, I demonstrate that biomarkers obtained from “omics” platforms can detect neuroimmunological phenomena in clinical and preclinical settings. In chapter one, DNA …

Optical Methods For Time-Resolved Dosimetry And Oximetry Of Ultra-High Dose Rate Radiation Therapy, Megan A. Clark

Dartmouth College Ph.D Dissertations

Radiotherapy (RT) is a cornerstone method used to treat over 50% of the 2 million new cancer diagnoses each year in the United States. The success of RT directly relies on an optimal balance between maximizing the dose to the tumor while minimizing dose to surrounding normal tissues. Achieving this balance is often challenging due to underlying radiation transport and the presence of anatomical constraints that limit the beam delivery geometry. In turn, minimizing healthy tissue toxicity prevents use of a more aggressive tumor killing approach, and even in curative cases may decrease the patient’s quality of life due to …

Characterization Of The Erv41-Erv46 Complex As A Retrograde Receptor For Misfolded Secretory Proteins, John Andrew Fuesler

Dartmouth College Ph.D Dissertations

The Endoplasmic Reticulum (ER), the site of secretory protein biosynthesis

provides a favorable environment to promote polypeptide folding, protein

oligomerization and export. Although the ER contains many chaperones and other

factors that assist in protein folding, this process is error prone. Eukaryotes have

evolved protein quality control checkpoints to maintain homeostasis in the secretory

pathway, however these processes are imperfect and may result in proteotoxicity

when toxic levels or aggregates of proteins arise. Mutations in proteins involved in

trafficking in the early secretory pathway are closely associated with disease states.

Therefore, it is of great interest to further understand how …

Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar

Dartmouth College Ph.D Dissertations

Cystic Fibrosis (CF) is a multisystemic genetic disorder caused by mutations in the CFTR gene, resulting in chronic pulmonary infections, hyperinflammation, and progressive lung damage. Among the pathogens that colonize CF lungs, Pseudomonas aeruginosa (P. aeruginosa) is predominant, infecting over 50% of adults with CF and developing antibiotic resistance over time. Current modulator therapies fail to address persistent bacterial infections, chronic inflammation, or irreversible lung damage, underscoring the need for novel therapeutic strategies. In our previous in vitro studies, we demonstrated that extracellular vesicles (EVs) secreted by primary Human Bronchial Epithelial Cells (HBECs) inhibit P. aeruginosa growth by reducing the …

Biochemical And Molecular Analysis Of Anr-Dependent Microoxic Fitness Factors In Pseudomonas Aeruginosa, Stacie E. Balsam

Dartmouth College Ph.D Dissertations

Pseudomonas aeruginosa is a prominent opportunistic pathogen that is often found in microoxic environments like sites of infection and colony biofilms. P. aeruginosa can grow at oxygen (O2) at concentrations as little as 3 μM and also grows anaerobically by generating energy using nitrate as an alternate electron acceptor. An important way P. aeruginosa adapts to low O2 is through Anr, a transcription factor that upregulates many genes important for microoxic and anoxic fitness.

Specifically, Anr regulates mhr which encodes a hemerythrin protein (Mhr) that binds O2 with affinities relevant to microoxia and is also necessary for full fitness of …

Improving The Figure Of Merit In Iron-Vanadium-Aluminium Thermoelectric Alloy System Guided By Computational Modeling, Tao Fang

Dartmouth College Ph.D Dissertations

Thermoelectric materials can convert a thermal gradient to electricity. Currently, commercialized Bi₂Te₃ is brittle and expensive, which restricts the usage of this material. Compared to other thermoelectric materials, Fe₂VAl is cost-effective, stable and more robust mechanically. However, the figure of merit (zT) had been much lower than Bi₂Te₃. In this thesis, our main goal is to improve the figure of merit in Fe₂VAl system guided by computational modeling. We will start the discussion by presenting the Ge doped Fe₂VAl sample with record thermoelectric figure of merit value. …

Understanding Oncology Physician Movement And Its Implications On Cancer Care Teams And Patients, Sarah L. Cornelius

Dartmouth College Ph.D Dissertations

Nearly 20% of oncology physicians planned to move to new practices or leave practice altogether in 2023, with common stressors related to limited staffing and increased clinical burden. This combination of movement and departures is collectively referred to as turnover. High-quality cancer care relies on access to well-staffed and coordinated clinical teams, and thus, turnover within these teams can compromise care access, delivery, and quality. Prior research within primary care has demonstrated that turnover can result in delayed or worsened care and higher health care spending. However, there are limited studies of turnover within the oncology workforce. Understanding how oncology …