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Calculation Of Proton Transmembrane-Electrostatic Interaction Force And Elucidation Of The Water Droplet Experiment With A Transient Protonic Front, James Weifu Lee

Chemistry & Biochemistry Faculty Publications

The “transmembrane-electrostatically localized proton(s)/cation(s) charge(s) (TELC(s), also known as TELP(s)) model” may serve as a theoretical framework to explain protonic cell energetics including both delocalized and localized protonic couplings. TELCs are held by their corresponding transmembrane-electrostatically localized hydroxides anions (TELAs) across the membrane through mutual transmembrane-electrostatic attractive force, which is now calculated to be in the range from 1.96 × 10⁻¹¹ to 2.28 × 10⁻¹¹ newtons (N) across a 2.5 nm thick membrane in a range of transmembrane potential from 10 to 200 mV. At a moderate transmembrane potential (100 mV), the protonic transmembrane attractive force is now calculated to …

M Star Opacities: The B³Π–X³Δ Band System Of Tio, Peter F. Bernath, Manish Bhusal, Mirek R. Schmidt

Chemistry & Biochemistry Faculty Publications

The spectra of titanium monoxide (TiO) are used to classify M stars. TiO experimental cross sections based on a high-resolution emission spectrum recorded with a Fourier transform spectrometer at the National Solar Observatory are used for the analysis of the TiO B³Π–X³Δ transition (𝛾' system). The 3–2 and 4–3 vibrational bands are analyzed for the first time, and the analysis of the 2–1 band is revised. The transition dipole moment function from an ab initio calculation is used to calculate the band strengths. These band strengths are used to produce a B³Π–X³Δ line list for the vibrational levels v' ⩽ …

Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim

Chemistry & Biochemistry Faculty Publications

Adansonia digitata and Annona muricata are traditionally used medicinal plants with reported pharmacological properties. In this study, we aimed to elucidate the phytochemical composition, antioxidant activity, and antibacterial properties of partition fractions of Adansonia digitata and Annona muricata extracts obtained using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. The plant extracts were successively partitioned using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. Phytochemical analysis was performed using standard methods. Antioxidant activity was evaluated using FRAP and DPPH assays. Antibacterial activity was assessed using agar well diffusion and MIC determination. Phytochemical analysis revealed the presence of alkaloids (10.2-15.6%), flavonoids …

Twenty Years Of Global Stratospheric Fluorine Inventories From Atmospheric Chemistry Experiment Fourier Transform Spectrometer (Ace-Fts) Measurements, N. Raymond, P. Bernath, C. Boone, M. Chipperfield

Chemistry & Biochemistry Faculty Publications

We present fluorine inventories calculated for twenty years (2004–2023) and five latitude bands (82°–60°N, 60°–30°N, 30°N–30°S, 30°–60°S, and 60°–82°S) at altitudes from the surface up to 55 km. The inventories were calculated using the Atmospheric Chemistry Experiment Fourier transform spectrometer (ACE‐FTS) version 5.2 retrievals of the volume mixing ratios (VMRs) of 15 fluorine‐containing species. Of these 15 species, 3 are product gases: HF, COF₂, COCIF, and 12 are source gases: SF₆, PFC-14 (CF₄), CFC-11 (CCl₃F), CFC-12 (CCl₂F₂), CFC-113 (CCIF₂CCl₂F), HCFC-22 (CHF₂CL), HCFC-141b(C₂H₃Cl₂F), HCFC-142b ( …

Antihypertensive Potential Of Euphorbia Hirta And Leptadenia Hastata In Adrenaline-Induced Wistar Rats, Fagbohun Oyenike Bushirat, Emmanuel Ogar Ochonung, Messiah Innocent Atapia, Hassan Abdulsalam Adewuyi, Sakariyau Aido Waheed, Adebimpe Oluwatoyin Hameedah, Chizoba Victory Obunadike, Adeleye Adegboyega Edema, Samad Hussein, Abiola Mohammed Usman, Tolulope Olukayode Jaiyeola

Chemistry & Biochemistry Faculty Publications

Background: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.

Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats

Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.

Results: Antioxidant activity: …

Extended Inter-Laboratory Characterization Of The New Coastal Seawater Dissolved Organic Matter Reference Material Trm-0522, Alexander J. Craig, Lydia Babcock-Adams, Maxime C. Bridoux, Charlotte Brun, Juliana D'Andrilli, Aleksandar I. Goranov, Patrick G. Hatcher, Oliver Lechtenfeld, Hang Li, Rebecca Matos, Garrett Mckay, Amy M. Mckenna, Madelyn Miller, Sasha Wagner, Margot E. White, Alexander Zherebker, Jeffrey A. Hawkes

Chemistry & Biochemistry Faculty Publications

Dissolved organic matter (DOM) reference materials are critical to ensuring reliable comparability of measurements across experiments and between labs. TRM-0522, isolated in 2022 from 45 m deep seawater off of Sweden’s west coast, fills the niche of a previously unavailable coastal marine DOM reference material. After its isolation, we detailed a limited number of metrics for TRM-0522, initially disclosing Orbitrap high-resolution mass spectrometry, nuclear magnetic resonance, carbon proportion, absorbance, and fluorescence data. With TRM-0522 becoming more widely used, a variety of labs have generated different metrics that help to characterize and define the chemical properties of this coastal reference material. …

Experimental Demonstration And Study Of Transmembrane-Electrostatically Localized Protons Prevail, James Weifu Lee

Chemistry & Biochemistry Faculty Publications

In this review in relation to some interesting arguments from Silverstein, it is now reaffirmed that the experimental demonstration of transmembrane-electrostatically localized protons (TELPs) was successfully accomplished through 1) using an aluminum film as a TELPs sensor in a biomimetic anode water-membrane-water cathode system, 2) analyzing the water-electrolysis current curve, and 3) measuring bulk liquid phase pH. Formation of induced TELPs was subsequently discovered in an anode water-membrane-water-membrane-water cathode system. The discovery of induced TELPs enabled clean experimental tests on the cation-TELPs exchange process by using sodium bicarbonate or potassium bicarbonate solution in the central liquid chamber. The sodium/TELPs exchange …

1 Of 84 The Discursive Tactics Of Perpetuating White Normativity In Public Education: A Critical Policy Discourse Analysis Of Anti-Crt Policies Across 18 States, Alison Wilson, Alissa Blair, Jason L. Endacott, Christopher Giller, Christian Z. Goering

Curriculum and Instruction Faculty Publications and Presentations

In recent years, state policies banning "divisive concepts" have proliferated as part of a coordinated effort to undermine racial justice by framing critical discussions of race as "indoctrination" and imposing ideological restrictions on curriculum and pedagogy. Using critical policy discourse analysis informed by a critical study of whiteness, this paper examines how 22 policy documents from 18 states operate discursively to shape the parameters of race-related discourse in public education. Our findings suggest that these policies employ three primary discursive maneuvers: (1) constructing false equivalencies that equate white discomfort with racial oppression, (2) appealing to "universal" values to obscure systemic …

General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero

School of Medicine Publications

Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.g. genotypes and gene expression levels) on a phenotype, particularly while accommodating routine issues, such as having related subjects' data in analyses. In this paper, we extend an existing composite kernel machine regression model to integrate two multi-omics data types, while accommodating for general correlation structures amongst outcomes. Due …

Macrowire For Intracranial Thrombectomy: An Early Experience Of A New Device And Technique For Anterior Circulation Large Vessel Occlusion Stroke, Kaustubh Limaye, Sami Al Kasab, Jaidevsinh Dolia, Mohamad Ezzeldin, Daniel Vela Duarte, Vinodh Doss, Sourabh Lahoti, David Hasan, Alejandro Spiotta, Ameer E. Hassan

School of Medicine Publications

Background and Purpose

Mechanical thrombectomy (MT) has become the standard of care for treatment of acute ischemic stroke secondary to large vessel occlusion up to 24 h from the last known normal time. With ADAPT and SOLUMBRA techniques, classically, a large bore aspiration catheter is delivered over a microcatheter and microwire crossing the clot to perform thrombectomy. Recently, a novel macrowire (Colossus 035 in.) has been introduced as a potential alternative to the use of microwire-microcatheter to allow the delivery of the aspiration catheter (ID = 0.070 in. up to 0.088 in.) over a macrowire alone.

Objective

To test the …

Educación Financiera Y Finanzas Personales En Universitarios Subgraduados De Puerto Rico, Brendaliz Soto Vega

Theses and Dissertations

Este trabajo investigativo se diseñó para indagar acerca del impacto de la educación financiera en las competencias económicas de estudiantes universitarios subgraduados que residen en el área metropolitana de Puerto Rico. El problema de estudio está dado por cómo afecta el acceso a Educación Financiera en los jóvenes. Se busca responder qué sucede con aquellas personas que deben resolver alguna situación vinculada a su economía, sin haber tenido, dentro de la educación formal o fuera de ella, espacios para aprender las herramientas básicas en torno a las finanzas personales. La problemática considera, además, qué sucede con quienes, por el contrario, …

Differences In Long Covid Severity By Duration Of Illness, Symptom Evolution, And Vaccination: A Longitudinal Cohort Study From The Inspire Group, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Sharon Saydah, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein

Department of Emergency Medicine Faculty Papers

Background: Although short-term outcomes of Long COVID have been described, longer-term physical and mental health outcomes of Long COVID are less well-established. This study sought to assess differences in long-term physical and mental health outcomes extending up to three years among those with current, resolved, and no Long COVID, as well as duration of Long COVID and vaccination status. Methods: This was a prospective, multisite, study of participants with SARS-CoV-2 infection from 12/7/2020-8/29/2022, with data collected through 4/2/2024. Surveys included validated tools for physical and mental health. Data were analyzed by Long COVID status (never-had, resolved, current), Long COVID duration …

The Great Scrape: The Clash Between Scraping And Privacy, Daniel J. Solove, Woodrow Hartzog

Faculty Scholarship

Artificial intelligence (AI) systems depend on massive quantities of data, often gathered by “scraping”—the automated extraction of large amounts of data from the internet. A great deal of scraped data contains people’s personal information. This personal data provides the grist for AI tools such as facial recognition, deep fakes, and generative AI. Although scraping enables web searching, archiving of records, and meaningful scientific research, scraping for AI can also be objectionable and even harmful to individuals and society.

Organizations are scraping at an escalating pace and scale, even though many privacy laws are seemingly incongruous with the practice. In this …

Unequal Ownership, Ofer Eldar, Rory Van Loo

Faculty Scholarship

Market concentration and weak competition do not just lead to lower efficiency but also result in corporate profits flowing primarily to wealthy households that own a disproportionate share of public corporations. We demonstrate that this is a growing distributional problem not only due to familiar reasons in the literature, most notably shifts in market power, but also due to changes in the socio-economic makeup of ownership. Over the past twenty years, households in the bottom 90 percent of wealth have seen their share of stock ownership decline by half. That is, the ownership of corporations has become increasingly concentrated among …

Bayesian Alloy Design With Additive Synthesis, Michael R. Sulwer

Dissertations, Master's Theses and Master's Reports

To reduce carbon emissions and increase power out, steam powerplants need to increase the operating temperatures and pressures of steam turbines to improve efficiency. This necessitates the development of high temperature alloys with superior strength and stability. This research aims to design a class of solid solution High Entropy Alloys (HEAs) to exceed the high temperature performance of commercial alloys like Haynes 230 while maintaining comparable costs for Advanced Ultra Supercritical (A-USC) steam cycles. This project integrates Bayesian optimization and Calculation of Phase Diagrams (CALPHAD) within an Integrated Computational Materials Engineering (ICME) framework to predict and optimize key material properties: …

Towards Developing Glut2 Specific Probes For Biochemical And Biomedical Applications, Abdelrahman Ismail

Dissertations, Master's Theses and Master's Reports

Facilitated Glucose transporters (GLUTs) are membrane proteins responsible for the uptake of simple sugars and other structurally similar metabolites in all mammalian cells. One of the hallmarks of cancer is dysfunctional sugar metabolism, known as the Warburg effect, and one of the manifestations of that effect is abnormal GLUT expression. There are 14 known GLUT proteins with different expression patterns in different tissues, and tumors tend to express certain GLUTs that are not present in surrounding healthy tissue. Therefore, selective targeting of GLUTs presents a potentially powerful tool for diagnostics and treatment of cancer and other diseases. This has been …

Stability And Resonance Of Cylindrical Wave Energy Converters, Gregory M. Ballen

Dissertations, Master's Theses and Master's Reports

With increased focus on wave energy converters that produce power in multiple degrees of motion, more tools are necessary to understand the behavior of these devices and cause them to reach critical resonance points. This thesis uses Floquet theory and a numerical solver to understand how a WEC of given parameters operating in surge, heave and pitch may approach points of instability using feedback control schemes. It finds that a WEC reaches these resonance points when the surge and pitch motions are driven to resonate at either the same frequency as the heave motion, or at half this frequency. This …

Energy Transitions In Underserved Communities: Meaningful Engagement To Address Energy Burdens And Air Pollution, Nyasha Milanzi

Dissertations, Master's Theses and Master's Reports

This report presents two connected studies focused on environmental justice and community engagement in energy transitions. The first study examines engagement practices in EPA-funded projects using interviews and public abstracts. Applying the EngageINFEWS framework, it analyses stakeholder dynamics and offers recommendations for working with underserved communities. Key insights include addressing power imbalances, securing funding, building capacity, and fostering communication. The second study centres on the REJuST project, which supports energy justice in a rural northern community impacted by public health concerns linked to a bioenergy facility burning wood, paper, plastics, and tire-derived fuels. I use survey data to explore resident …

Climate Planning, Energy Sovereignty, And Electric Vehicle Perceptions Among Michigan’S Tribal Nations, Alexis Belle Tater

Dissertations, Master's Theses and Master's Reports

Climate change will especially impact marginalized communities and communities with less government support for funding climate adaptation actions. The first chapter of this report focuses on climate change responses, specifically Tribal Nations in the state of Michigan. In the current U.S. context, funding for large climate change mitigation and adaptation projects in Tribal Nations can be achieved through federal funding from the CPRG (Climate Pollution Reduction Grant), which requires an established PCAP (Priority Climate Action Plans) to guide decision making in alignment with identified priorities. I discuss the importance of Tribal sovereignty, the potential implications of its inclusion and exclusion …

Molecular Modeling Methods And Applications For Accelerating Polymerization And Pyrolysis Studies, Joshua D. Kemppainen

Dissertations, Master's Theses and Master's Reports

Polymer matrix composites and carbon-carbon composites play critical roles in the aerospace, automotive, and construction industries. Different matrix materials and processing conditions can lead to a large variety of composite materials and composite properties. Integrated computational materials engineering has been used to tailor PMC matrix materials and processing conditions to specific properties and manufacturing techniques. The integrated computational materials engineering process modeling framework uses molecular dynamics at the nanometer length scale to characterize the evolving thermo-mechanical properties of the polymer as it cures. Then finite element analysis is used at the micrometer length scale to adjust cure cycles to tailor …

Leveraging Product And Process Characteristics Across The Concrete Pavement Life Cycle To Integrate Global Warming Potential Into Project Procurement Processes, Michelle Annette Cooper

Dissertations, Master's Theses and Master's Reports

The objective of this research is to support sustainable procurement of concrete pavements by linking materials-level global warming potential (GWP) to the project-level. Infrastructure owners require reliable environmental product declarations (EPDs) and methodologies for integrating GWP into the procurement process to ensure equitable decision-making. This work provides insights into current EPD reliability by assessing the sensitivity of concrete GWP to materials-level contributors to recommend a level of supply chain specificity needed to effectively communicate GWP. A benchmarking methodology was developed and implemented to establish reference values for procuring sustainable products. Having provided evidence towards EPD reliability, this work presents a …

Schaper Numbers, Palindrome Partitions, And Symmetric Functions, With Applications To Characters Of The Symmetric Group, Karlee J. Westrem

Dissertations, Master's Theses and Master's Reports

Finding the decomposition numbers for the symmetric group is a difficult problem and has led to many different research directions. For a given Specht module, the Schaper sum formula can be refined with knowledge of the Schaper number for the particular partition to give more precise information about the decomposition numbers. In Chapter 2, we give a combinatorial formula for the Schaper number when the partition has at most two columns. At the end, we provide a conjecture for the Schaper number for the partition of shaper (3^n).

Chapter 3 covers the joint work with my advisor, David Hemmer, and …

Phase-Field Method Of Fracture In Fiber-Reinforced Polymer Composites: Theory, Modeling, And Validation, Akash Kumar

Dissertations, Master's Theses and Master's Reports

Fiber-reinforced polymer composites (FRPCs) are widely used in aerospace, automotive, and civil engineering due to their high specific strength, stiffness, and durability. However, their anisotropic and heterogeneous nature makes fracture prediction challenging, with damage modes classified as intralaminar failure (matrix cracking, fiber breakage, fiber-matrix debonding) and interlaminar delamination. Delamination, driven by weak through-thickness strength and high interlaminar stresses, is a predominant failure mechanism in FRPCs. While cohesive zone models (CZMs) are commonly used for delamination, they are computationally expensive and inefficient for capturing intralaminar fractures where crack paths are unknown. To address this, we developed a unified phase field-based cohesive …

Distributing Composition: Rhetorical Agency In First-Year Writing, Elizabeth Novotny

Dissertations, Master's Theses and Master's Reports

This project centers on engaging students in class lessons related to rhetorical agency. Typically understood as the capacity to act, within rhetoric, I define agency as the capacity to make meaning. In most traditional Western conceptions, agency is primarily located with the individual rhetor. However, these views were increasingly challenged throughout the later twentieth century as theorists from various traditions came to understand that discussing our agency as solely our own doing was insufficient. In contrast to an individualistic understanding of agency, theories that characterize rhetorical agency as more fragmented have evolved, where, instead of writing and rhetoric being …

Great Lakes And Its Regional Climate In The Future, Miraj Bhakta Kayastha

Dissertations, Master's Theses and Master's Reports

The overarching objective of this dissertation is to enhance our predictive understanding of the Great Lakes regional climate by utilizing advanced modeling techniques and provide comprehensive insights into the future of the Great Lakes. This dissertation focuses on four areas pertinent to the future of the Great Lakes hydroclimate and extreme events, beginning with the derivation of robust water level projections for the Great Lakes in Chapter 2. Using a regional climate modeling system with a two-way coupled three-dimensional (3D) hydrodynamic lake and ice model for the Great lakes, we analyze long-term future changes in the over-lake precipitation, lake evaporation, …

Near-Infrared Fluorescent Cyanine Probes For Monitoring Nad(P)H Dynamics In Living Cells And Drosophila Larvae, May Waters

Dissertations, Master's Theses and Master's Reports

Nicotinamide adenine dinucleotide (NAD+/NADH) plays a critical role in cellular metabolism, with abnormally elevated NADH levels linked to disrupted metabolic processes and cancer. In this study, we developed near-infrared fluorescent probes to selectively measure NADH concentrations. We present five cyanine-based probes, which were optimized by modifying the connection bridges to fine tune electronics. Two NAD(P)H-biosensing probes consisting of 1,3,3-trimethyl-3H-indolium and 3-quinolinium acceptors, linked by thiophene, A, and 3,4-ethylenedioxythiophene, B, bridges are detailed. They exhibit near-infrared fluorescence at 742.1 nm and 727.2 nm for probes A and B, respectively, and generate absorbance signals at 690.6 nm and 685.9 nm. Probe A …

From Plasmonics To Superfluorescence: Engineering Light- Matter Interactions For Quantum Optical Phenomena, Aaron J. Wildenborg

Dissertations, Master's Theses and Master's Reports

This work presents different ways to engineer light-matter interactions by using nanostructures to exploit quantum-optical phenomena. First, sodium (Na) is predicted to be an ideal plasmonic material due to its ultra-low optical losses from the visible to the near-infrared (NIR). However, Na has practical limitations due to its high chemical reactivity. Using a scalable fabrication method for Na plasmonic nanostructures by combining phase-shift photolithography and a thermo-assisted spin-coating process, we produced nano-pit arrays of varying periodicities (300-600 nm), supporting tunable surface plasmon polariton (SPP) modes spanning visible to NIR. These structures demonstrated SPP resonances as narrow as 9.3 nm, with …

Biomedical Applications Of Reactive Oxygen Species From Catechol Oxidation, Zhongtian Zhang

Dissertations, Master's Theses and Master's Reports

Catechol, a key functional moiety found in mussel adhesive proteins, undergoes oxidation to generate reactive oxygen species (ROS), which can be leveraged for biomedical and environmental applications. By modifying catechol-based polymers, ROS generation can be controlled and applied toward organic compound degradation, antimicrobial treatments, and polymer crosslinking. This dissertation focuses on the design and application of catechol-based materials that leverage ROS generation for biomedical and environmental applications.

Linear Response Of Driven Non-Hermitian Photonic Systems, Lucas R. Simonson

Dissertations, Master's Theses and Master's Reports

The notion of non-Hermitian engineering in optics and photonics has attracted considerable attention in the past decade. From laser devices and sensing applications to light trapping and guiding, non-Hermitian engineering provides additional degrees of freedom that allows for more control over light-matter interaction. It is thus of great importance to develop a deep insight into the linear response of non-Hermitian optical systems. We begin by studying the linear response of non-Hermitian Hamiltonian systems under general conditions and derive an expression for its Green's operator in terms of its eigenvectors and its canonical Jordan vectors. Next, we investigate the quantum noise …

Ansi Z97 Impact Testing Of Thin Glass, Justin P. Anthony

Dissertations, Master's Theses and Master's Reports

To determine whether thin glass constructions can pass Z97 impact test to qualify as safety glass an extensive protocol was performed. Constructions including monolithic, chemically strengthened, filmed, laminated, and triple pane insulated glass units comprised of thin glass ranging in thickness between 0.50 mm and 1.6mm were evaluated. Test results indicate annealed specimens, and laminated specimens performed similar to constructions with 3 mm and 6 mm glass. Specimens with 0.2 mm film consistently performed as safety glass for thicknesses between 0.7 mm and 1.6 mm and similar performance for specimens with 0.1 mm film with thickness of 1.1 mm and …