Digital Commons Network^™

The Infected Diabetic Foot: Risk Factors For Re-Infection After Treatment For Diabetic Foot Osteomyelitis, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, Tyler L Coye, Matthew Sideman, Michael C Siah, Arthur N Tarricone

Center on Aging Staff Publications

Our objective was to evaluate risk factors for re-infection in patients after treatment for diabetic foot osteomyelitis (OM). We used pooled patient level data from two RTCs that evaluated patients with diabetic foot infections. We evaluated 171 patients with OM. OM was confirmed with bone culture or histopathology. Data from the 12-month follow-up were used to determine clinical outcomes. Re-infection occurred in 47 (27.5%) patients. Risk factors for re-infection were Toe Brachial Index < 0.40 (25.7% vs. 9.8%, p = 0.02), skin perfusion pressure < 40 mmHg (6.3% vs. 5.9%, p = 0.04), wound healing (55.3% vs. 75.0%, p = 0.01), time to heal (156.0, 69.5-365 vs. 91.5, 38.8-365, p = 0.001), and history of MI (14.9% vs. 3.2%, p = 0.005). During 12-month follow-up, patients with re-infections were 198.8 times more likely to require a foot related hospitalisation (81.8% vs. 0.0%, p = 0.001), 10.4 times more likely have an all-cause hospitalisation (70.2% vs. 18.5%, p = 0.001) and 9.4 times more likely to need an amputation (36.2% vs. 5.6%, p = 0.001). Patients with re-infection had a significantly longer median length of hospitalisation (20.0, 13.5-34.5 vs. 14.0, 10.0-22.0, p = 0.003) and median length of antibiotic duration (55.0, 35.0-87.0 vs. 46.0, 22.8-68.0, p = 0.03). Patients with re-infection are less likely to heal and have more foot-related hospitalizations and amputations.

Flyphonedb2: A Computational Framework For Analyzing Cell-Cell Communication In Drosophila Scrna-Seq Data Integrating Alphafold-Multimer Predictions, Mujeeb Qadiri, Ying Liu, Ah-Ram Kim, Myeonghoon Han, Eric Zhou, Austin Veal, Tzu-Chiao Lu, Hongjie Li, Yanhui Hu, Norbert Perrimon

Center on Aging Staff Publications

Cell-cell communication (CCC) plays a critical role in the physiological regulation of organisms and has been implicated in numerous diseases. Previously, we introduced FlyPhoneDB, a tool designed to explore CCC in Drosophila single-cell RNA-sequencing datasets. The core algorithm of FlyPhoneDB infers tissue-specific signaling events between cell types by calculating cell-cell interaction scores based on curated ligand-receptor (L-R) expression across major signaling pathways. However, the utility of FlyPhoneDB was limited by the relatively small number of available L-R pairs.

Here, we present FlyPhoneDB2, a major upgrade featuring a significantly expanded knowledgebase that includes a greater number of L-R pairs, incorporating annotations …

Talking About Suffering In The Intensive Care Unit, Brent M Kious, Judith B Vick, Peter A Ubel, Olivia Sutton, Jennifer Blumenthal-Barby, Christopher E Cox, Deepshikha Ashana

Center for Medical Ethics and Health Policy Staff Publications

Background: Some have hypothesized that talk about suffering can be used by clinicians to motivate difficult decisions, especially to argue for reducing treatment at the end of life. We examined how talk about suffering is related to decision-making for critically ill patients, by evaluating transcripts of conversations between clinicians and patients' families.

Methods: We conducted a secondary qualitative content analysis of audio-recorded family meetings from a multicenter trial conducted in the adult intensive care units of five hospitals from 2012-2017 to look at how the term "suffering" and its variants were used. A coding guide was developed by consensus-oriented discussion …

Examining Treatment Options In Youth With Major Depressive Disorder: Observations From The Tx-Ydsrn Registry Study, Emine Rabia Ayvaci, Karabi Nandy, Ryan Becker, Laura Stone, Abu Minhajuddin, Holli Slater, Lynnel C Goodman, Sarah M Wakefield, Eric A Storch, Joseph C Blader, Cesar A Soutullo, Graham J Emslie, Madhukar H Trivedi

Center for Medical Ethics and Health Policy Staff Publications

Objective: Treatment decisions for depression are a complex process, influenced by factors such as clinical characteristics, socioeconomic factors, and patient/caregiver preferences. This study examines the characteristics of treatment options during the first month of enrollment among depressed youth.

Methods: Data for 646 depressed youth were extracted from the Texas Youth Depression and Suicide Research Network study. Participants' treatments during the first month were categorized as no treatment (NT), psychotherapy only (THER), pharmacotherapy only (MED), or a combination of psychotherapy and pharmacotherapy (COMB). Sociodemographic and clinical features were compared across these treatment types.

Results: 7% were on NT, 5% on THER, …

The (Im)Possibility Of Separating Rabbinic Texts Into Literary Genres: Form Analysis And Text Linguisticslysis And Text Linguistics, Rivka Ulmer

Faculty Journal Articles

This paper analyzes rabbinic homiletic texts from the perspective of form analysis in combination with text-linguistic theories. My study indicates that, from the perspective of functional considerations, it is not meaningful to lift small literary forms from a coherent text that depends on a co-text to create meaning. Additionally, the concepts of genre and parable need to be abandoned and replaced by text-type and mashal. The form-analytical description of rabbinic homilies is based on research performed at the Institute of Judaic Studies in Frankfurt am Main. The text-linguistic concepts are based on strict formalizations that demonstrate textual relations.These theories were …

A Method For Empirically Assessing Small Area Estimators Via Bootstrap-Weighted K-Nearest-Neighbor Artificial Populations, With Applications To Forest Inventory, Grayson W. White, Jerzy Wieczorek, Zachariah W. Cody, Emily X. Tan, Jacqueline O. Chistolini, Kelly S. Mcconville, Tracey S. Frescino, Gretchen G. Moisen

Faculty Journal Articles

National Forest Inventories monitor forest attributes across a variety of spatial and temporal scales in a given country. Increased interest in reporting and management at smaller scales has driven National Forest Inventories to investigate and adopt small area estimation (SAE) due to the promise of increased precision at these scales. However, comparing and evaluating SAE models for a given application is inherently difficult. Typically, many areas lack enough data to check unit-level modeling assumptions or to assess unit-level predictions empirically; and no ground truth is available for checking area-level estimates. Design-based simulation from artificial populations can help with each of …

Shall I: Do The Motivations For Breakup Sex Differ Across Different Scenarios?, T. Joel Wade, Zoe Macuto

Faculty Journal Articles

This research investigated endorsement of the 4 motivators (relationship maintenance, ambivalence, hedonism, miscellaneous) for engaging in breakup sex across three relationship breakup scenarios, i.e., a breakup occurred due to: general reasons, infidelity, and being in a long distance relationship using an online questionnaire with a primarily White, primarily heterosexual sample (n = 304, Mage = 20.67). Results indicated that women are more likely than men to engage in breakup sex for relationship maintenance reasons when the breakup is due to general reasons, and for a long distance breakup scenario, non-heterosexuals engage in breakup sex for relationship maintenance reasons, and overall …

The Influence Of Familial Nudging On Attitudes Toward Climate Change And Monetary Contributions: An Exploration Of Ease And Difficulty With Evidence From Japan, Canada, The Usa, And Norway, Hidenori Komatsu, Hiromi Kubota, Kenji Asano Asano, Yu Naga, Catherine Salmon, David Widman, Elisabeth Oberzaucher, T. Joel Wade, Leif Edward Ottesen Kennair, Maryanne L. Fisher, Rebecca Burch, Ryoko Takikawa, Samara Rice

Faculty Journal Articles

Climate change countermeasures require monetary investment for implementation through regulations, often in the form of public taxes. Therefore, public opinion on climate change is an important factor in achieving carbon neutrality (CN). How public perception is formed, leading to motivation to fund measures for CN, needs to be identified. This study aimed to identify the causal structures of attitude change leading to financial investment through two surveys in multiple countries using nudging messages emphasizing familial support (familial nudging), which is effective in promoting pro-environmental attitudes. Study 1 (2023) examined how familial nudging moderates risk-averse attitudes toward climate change. Despite successful …

Using Abandoned Model Systems And Historical Literature To Teach Modern Concepts And Techniques In Cell Biology, Leocadia V. Paliulis, Gunar Fabig, Sandra Stein, Silke Tulok, Anja Nobst, Chukwuebuka William Okafornta, Thomas Kurth, Thomas Müller-Reichert

Faculty Journal Articles

The cell biology literature of the 19th and early-to-mid 20th centuries is full of the seminal works that were critical for the development of our current understanding of biology but were done using model systems that are no longer commonly used. We argue that these historical papers are ideal for the development of course-based research experiences, both because the background work is conceptually and technically straightforward, and because the study of the abandoned systems stopped prior to the availability of modern techniques. These abandoned systems offer outstanding opportunities for teaching modern light and electron microscopy techniques, thus providing students with …

A Biphasic Microstructural Model Of Skeletal Muscle To Study Structure-Function Mechanisms Under Multiaxial Tensile And Compressive Conditions, Benjamin Wheatley, Minhaj U. Bhuiyan, Sabrina S. Lorza, Kevin M. Moerman, Pierre-Yves Rohan

Faculty Journal Articles

No abstract provided.

A Framework For Fair And Trustworthy Multimodal Video Anomaly Detection: Fusion, Dataset Quality Auditing, Explainability, And Fairness, Omeshamisu Judith Anigala

Electronic Theses and Dissertations

No abstract provided.

Programming Carcass Composition Through Gestational Nutrition, Sydni Elise Borders

Electronic Theses and Dissertations

The objective of this study was to evaluate the influence of maternal nutrient restriction during mid-gestation on the performance of the dam, feeding performance, carcass composition, and genetic expression in the offspring. Cows (n = 46) were randomly assigned to one of two treatments based on global nutrient intake: 1) fed to achieve and/or maintain a BCS of 5 or 6 (Positive Energy Status [PES]; n = 24) or 2) fed to lose one BCS during 99 days of mid-gestation (Negative Energy Status [NES]; n = 22). Cows in NES had greater decreases (P < 0.05) in body fat stores and muscle mass, elevated NEFA concentrations, and displayed decreased (P < 0.05) DMI, HP, and GHG emissions. There were no differences in milk components or volume produced between treatments (P > 0.05). There were no differences in …

Evaluation Of Strip-Tillage And Banded Phosphorus And Potassium Fertilizer For Corn Production In Eastern South Dakota, Charles N. Tesch

Electronic Theses and Dissertations

In South Dakota, the adoption of no-till and other conservation tillage practices has grown in recent years. However, conventional tillage is still a common practice in the eastern third of the state, negatively affecting soil health and the environment. Strip-tillage has gained interest in this region as a way to transition to conservation tillage while retaining some benefits of conventional tillage. Strip-tillage also provides the ability to subsurface band nutrients, particularly phosphorus (P) and potassium (K) fertilizers within the tillage strip, potentially improving nutrient accessibility and recovery while reducing environmental risks. This study aimed to investigate (i) the effects of …

Modern Feminist Social Movements In Rural America: A Three- Part Study, Susan Kroger

Electronic Theses and Dissertations

Modern feminist social movement can be characterized by several distinctive features. The use of social media, the incorporation of intersectionality, and the injection of policy into modern social movements requires a broad approach to these movements that allows for examination from multiple angles. The proposed project allows for a nuanced and thorough look into an existing social movement in rural America as it unfolds and examines that movement through several lenses. Additionally, the project incorporates current social movement and feminist theory and notes the importance of examining these theoretical perspectives through an applied lens: in order for change to occur, …

Impact Of Natural Feed Additives And Monensin Sodium On Growth Performance In Feedlot Cattle, Thiago Lauro Maia Ribeiro

Electronic Theses and Dissertations

The objective of this dissertation was to investigate how phytogenic feed additives and a pulse feeding monensin sodium strategy would affect growth performance in the receiving and finishing feedlot phases. Three randomized complete block design feedlot experiments and one pooled analysis were conducted to determine the effects of the feed additives and management strategies used in newly weaned and finishing beef cattle. The objective of these experiments were 1) determine if a blend of capsicum oleoresin, clove essential oil, and garlic essential oil (CCG) influences cattle performance, sera metabolites or health outcomes during the feedlot receiving phase; 2) determine if …

Biotransformation Of Camelina Meal Via Pretreatment And Fermentation For Functional And Nutritional Upgrading, Ram Kumar Bhattarai

Electronic Theses and Dissertations

Camelina sativa, an oilseed crop of the Brassicaceae family, has seen increased cultivation in North America in response to the rising demand for biofuels over the past two decades. With this growth, camelina meal, a byproduct of oil extraction, has emerged as a promising yet underutilized resource, particularly for applications in animal nutrition. This study aimed to evaluate the potential of camelina meal as a substrate for submerged fungal fermentation and to examine how this bioconversion affects its physicochemical and nutritional properties. The influence of mild pretreatments (unwashed, washed only, and washed/dried and ground) on fermentation outcomes was also assessed. …

One Rung At A Time: Climbing The Ladder Toward Aquatic Connectivity In Eastern South Dakota, Evan Spencer

Electronic Theses and Dissertations

Roads and streams are synonymous with their connection to movement, the acquisition of resources, and as pathways to new opportunities. However, the factors that define good roads and ecologically connected streams are rarely without conflict. Road infrastructure at stream-road crossings has the potential to fragment stream networks. Tube culverts, where streams pass under the road through metal pipes, are particularly concerning for stream connectivity. Undersized, aging, or inappropriately installed culverts can develop vertical drops at the outflow due to high velocities and stream bed scouring. The outlet drop can function as a barrier, preventing the upstream movement of fish. Due …

The Macroalgal Composition Differs Among Depths And Zones In Cuban Mesophotic Coral Reef Ecosystems, Beatriz Martínez-Daranas, M. Dennis Hanisak, Patricia M. González-Sánchez, Stephanie Farrington, John K. Reed

Faculty Scholarship

Previously the algal community of Cuban mesophotic coral reef ecosystems (MCEs) has not been characterized quantitatively. The objective of this study was to explore the distribution of macroalgae around Cuba and their depth profiles within the mesophotic zone (30−150 m). Data on the algal community were obtained in 2017 during 43 ROV (remotely operated vehicle) dives around Cuba’s shelf. Scientists specializing in algal taxonomy watched the live ROV video on board the ship and recorded algal presence every ~5—10 min in a database. Algae were identified to the lowest possible taxa, and algal presence/absence was analyzed in 20 m depth …

Untargeted Metabolome Atlas For Sleep-Related Phenotypes In The Hispanic Community Health Study/Study Of Latinos, Bing Yu, M Larissa Avilés-Santa, Eric Boerwinkle, Martha L Daviglus, Robert Kaplan, Jianwen Cai, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

BACKGROUND: Sleep is essential to maintaining health and wellbeing of individuals, influencing a variety of outcomes from mental health to cardiometabolic disease. This study aims to assess the relationships between various sleep-related phenotypes and blood metabolites.

METHODS: Utilising data from the Hispanic Community Health Study/Study of Latinos, we performed association analyses between 40 sleep-related phenotypes, grouped in several domains (sleep disordered breathing (SDB), sleep duration, sleep timing, self-reported insomnia symptoms, excessive daytime sleepiness (EDS), and heart rate during sleep), and 768 metabolites measured via untargeted metabolomics profiling. Network analysis was employed to visualise and interpret the associations between sleep phenotypes …

Predictors Of Donor-Site Wound Complications Following Fibula Free Flap Reconstruction

Faculty, Staff and Student Publications

Objective: The fibula free flap (FFF) remains the workhorse flap for head and neck defects necessitating osteocutaneous reconstruction. Although lower extremity angiography, ultrasound (US), and other vascular studies are routinely used for fibula assessment and patient selection, predictors of donor-site morbidity following harvest remain poorly understood. We sought to investigate the factors associated with FFF donor-site complications.

Study design: Retrospective analysis of patients at a tertiary care center.

Setting: Tertiary care center.

Methods: In total, 119 patients undergoing FFF reconstruction during the years 2012 to 2022 were included. Multivariable logistic regression was used to identify independent predictors of soft-tissue donor-site …

Use Of Digital Health Interventions For Cancer Prevention Among People Living With Disabilities In The United States: A Scoping Review, Yasmine Zerrouki, Christine Markham

Faculty, Staff and Student Publications

BACKGROUND: The use of digital health strategies for cancer care increased dramatically in the United States over the past 4 years. However, a dearth of knowledge remains about the use of digital health for cancer prevention for some populations with heath disparities. Therefore, the purpose of the present scoping review was to identify digital health interventions for cancer prevention designed for people with disabilities.

METHODS: This scoping review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews and the Arksey and O'Malley methodological framework. The Embase, PubMed, Ovid MEDLINE, and CINAHL/EBSCO databases were …

Association Between Trust In The Incumbent President And Covid-19 Preventive Behaviors During The Pandemic In Four Latin American Countries, Sergio Mauricio Moreno-López, Fernando López, Deborah Salvo, Rodrigo Siqueira Reis, Guillermo Rosas, Andrea Ramírez-Varela

Faculty, Staff and Student Publications

The COVID-19 pandemic revealed disparities in policy responses in Latin America. We examined the association between trust in the president and COVID-19 preventive behaviors in Brazil, Chile, Colombia, and Mexico. We used data from the Collaborative COVID-19 Response Survey by the McDonnell Academy at Washington University in St. Louis (United States), from September 2020 to March 2021. Nonprobabilistic sampling included adult citizens from the four countries. Multivariate negative binomial regression models were applied. The study included 8,125 participants, with Brazil showing the lowest adherence to preventive behaviors (65.5%). Increased adoption of preventive behaviors was linked with ages 18-26 (aIRR = …

Assessing Sun Protection Policies In Texas School Districts Located In Counties With The Lowest And Highest Melanoma Risk: Content Analysis And Cross-Sectional Study, Karl Schrader, Cici Bauer, Kelly C Nelson, Jennifer Cofer

Faculty, Staff and Student Publications

Introduction

School policy can encourage sun safe habits, such as wearing hats and applying sunscreen. However, sun safety policies (SSP) have not been formally assessed for Texas independent school districts (ISDs), particularly in counties with the highest melanoma incidence relative risk (RR). This study aims to assess the presence, strength, and intent of SSPs across Texas ISDs located in counties with the highest and lowest melanoma incidence. We also identify factors correlated with stronger SSP.

Methods

Eleven components of SSPs from 102 ISDs were evaluated in this cross-sectional study by examining school district websites, official documents, social media, media appearances, …

Risk Of Post-Acute Symptoms Among Adults: A Comparison Study Of Severe Covid-19, Pneumonia, And Influenza

Faculty, Staff and Student Publications

Background: A retrospective cohort study was undertaken to assess the relationship between initial disease severity of COVID-19 and the risk of post-acute symptoms. The COVID-19 cohort was compared against influenza and pneumonia cohorts to assess whether risk of post-acute symptoms differed.

Methods: Administrative health claims data were obtained for commercially insured and Medicare Advantage covered adults (≥ 18 years) with symptomatic laboratory-confirmed COVID-19 diagnosed in 2020 (n=121,205), and similar cohorts of influenza (n=20,844) and pneumonia (n=29,052) patients diagnosed prior to the pandemic. Post-acute symptoms were assessed at four weeks, three and six months following initial diagnosis.

Results: Among the patients …

Protocol For The Houston Hospital-Based Violence Intervention Program, Sarah Beth Abbott, Brian Heckler, Lillian S Kao, Ruosha Li, Susannah Meg Michael, Heidi M Mcpherson, Marisol Nieves, Christian P Owen, Kevin Rix, Hema Sarvani Jalaparthi, Vanessa Schick, Shreela V Sharma, Carlie Stratemann, Anne Marie V Thompson, Jack Tsai, Zixi Yang, Sandra Mckay

Faculty, Staff and Student Publications

Firearm violence is a leading cause of injury and mortality in the United States. Hospital-based violence intervention programs (HVIPs) are a promising public health strategy designed to reduce recurrent violence by engaging patients during hospitalization and connecting them to support services after discharge. This protocol describes the design and implementation of the Houston Hospital-Based Violence Intervention Program (Houston-HVIP), which will be evaluated by a randomized controlled trial conducted at a Level 1 trauma center in Houston, Texas. The study plans to enroll individuals aged 16-35 who present with gunshot wounds (GSW) at the Level 1 trauma center. Participants are randomized …

The Impact Of Insurance On Adolescent Transition To Adult Care, Albert C Hergenroeder

Faculty, Staff and Student Publications

Background: This study sought to examine how adolescents and young adults with special health care needs (AYA) prepare for managing medical insurance (private and public) as an adult and the role of insurance in locating an adult provider and engaging in care.

Methods: Twenty-eight AYA aged 18-24 years with renal, inflammatory bowel, or rheumatologic diseases completed individual semi-structured interviews designed to evaluate the impact of insurance (private vs. public) on their health care transition experiences. An interdisciplinary team of coders analyzed transcripts using The Framework Method.

Results: Three themes emerged: continuum of accepting health insurance responsibility; the impact of insurance …

Phenotypic Variation In Disease Severity Among Hospitalized Pediatric Patients With Covid-19: Assessing The Impact Of Covid-19 In The Epico Study, María Camila David, Pablo Vásquez-Hoyos, María Lucía Mesa-Rubio, Luis Miguel Navarro-Ramirez, Sergio Moreno-Lopez, Olga Lucía Baquero, Luz Marina Mejía, Juan Gabriel Piñeros, Sonia Restrepo-Gualteros, Carlos Álvarez-Moreno, Alejandro Díaz-Díaz, Iván Gutierrez-Tobar, Andrés Camilo Mesa, William Ricardo Bachiller Tuta, Clara Esperanza Galvis Diaz, Martha Africano, José Manuel Nieto, Paola Marsela Pérez Camacho, Rosalba Vivas Trochez, Irati Gastesi, Cinta Moraleda, Alfredo Tagarro García, Blanca Herrero, Lourdes Calleja, Carlos Grasa, Paula Rodriguez, Susana Melendo, Antoni Soriano-Arandes, Irene Gómez Pastrana, Sonsoles García García, Victoria Fumado, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Objective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.

Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.

Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, …

Dental Care Trajectories Among Formerly Incarcerated Older Adults In The United States, Dylan B Jackson, Ana C Neumann

Faculty, Staff and Student Publications

A growing body of research has documented an association between prior incarceration and lower dental care use, yet the longitudinal impact of prior incarceration on dental care patterns over time among older adults remains unexplored. This study aims to investigate whether prior incarceration is associated with differing trajectories of dental care use among older adults in the United States. Data were drawn from the 2012-2020 waves of the Health and Retirement Study (HRS), a nationally representative longitudinal survey of older adults in the United States (n =  5,893). Group-based trajectory modeling was used to estimate dental care use patterns over …

Constructing A Conversation-First Dialogue Model For Comprehensive, Evidence-Based Counseling For Hpv Vaccination For Young Adults, Ana C Neumann, Daniel Rhee, Cui Tao, Licong Cui, Muhammad Tuan Amith

Faculty, Staff and Student Publications

The human papillomavirus (HPV) vaccine has been shown to prevent several types of cancers; however, vaccination rates remain suboptimal. Effective patient-provider communication is key to promoting vaccination but is often hindered by various clinical barriers. Speech bots could be a promising solution by addressing common barriers and facilitating HPV vaccination uptake. We used a "conversation first" design approach to develop the interaction for speech bots to deliver HPV vaccination counseling to young adults. Two counseling strategies were developed and piloted: motivational interviewing (MI) and the theory-based approaches. Wizard of Oz experiments were conducted with young female adults (n = 24). …

A Scoping Review Of The Social Determinants Of Pediatric And Adolescent Obesity, Jayna M Dave

Faculty, Staff and Student Publications

Context: Social determinants of health (SDOH) play a large role in pediatric and adolescent metabolic health worldwide.

Objective: The study is aimed at exploring key SDOH related to childhood obesity, worldwide.

Methods: Primary research articles from PubMed, Embase, and Medline databases published between 2013 and 2023, had a study population of 0-19-year-olds, and examined the association between WHO-defined SDOH and childhood obesity were included. Non-English papers and those outside WHO-defined SDOHs were excluded. Two reviewers independently performed a blinded screening of titles and abstracts, followed by a full-text assessment of selected articles.

Results: Of the 703 initial articles, 22 duplicates …