Digital Commons Network^™

Upar-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation To Stabilize Atherosclerotic Plaques, Hsin Yin Chuang, Huari Kou, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Atherosclerosis is characterized by lipid deposition, chronic inflammation, and apoptosis within the arterial wall, leading to plaque progression and instability. Current lipid-lowering therapies fail to fully address residual cardiovascular risk driven by local inflammation and cell death. Here, we report the development of uPA-functionalized, rapamycin-encapsulated dendrimer nanoparticles (G5PM-uPA/RA) that preferentially accumulate in urokinase plasminogen activator receptor (uPAR)-enriched atherosclerotic plaque, including macrophage- and apoptosis-rich lesion microenvironments. G5PM-uPA/RA was constructed by cross-linking reaction-enabled flash nanoprecipitation in a custom-made multi-inlet vortex mixer, followed by thiol-maleimide conjugation of uPA for uPAR-guided targeting. The nanoparticles demonstrated uniform morphology, favorable stability, and efficient rapamycin loading. In …

Spatiotemporal Trends In Schistocephalus Solidus Infection Among Populations Of Alaskan Threespine Stickleback (Gasterosteus Aculeatus), A.M Wohlleben, Neva Meyer, N.C. Steinel

Biology

Understanding the dynamics of host-parasite interactions is essential for uncovering the ecological and evolutionary processes shaping natural populations. In this study, we investigated the spatial and temporal patterns of prevalence of the cestode Schistocephalus solidus in 4 Alaskan populations of threespine stickleback (Gasterosteus aculeatus) over 11 years (1996 to 2006). Additionally, we assessed host tolerance through key indicators such as the Parasite Index and the presence of fibrotic scar tissue, a specialized form of resistance in this system. We observed fibrosis formation in both infected and uninfected fish across all populations, with notable year-to-year variability in Cornelius Lake. Here, fibrosis …

Matter Of 647 Prospect, Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

The Appellate Division, Second Department affirmed denial of landlord's Article 78 petition challenging a DHCR rent overcharge determination. A tenant filed an overcharge complaint in 2017; DHCR found an overcharge using a June 2013 base date and calculated the base date rent pursuant to a 2014 DHCR rent overcharge order. The court upheld DHCR's reliance on the 2014 order — issued within the four-year limitations period and imposing obligations on landlord with respect to the base date — notwithstanding that it was premised on pre-base date rental history.

Edgecombe Realty, Llc V. Cano

All Decisions

In this nonpayment proceeding in a rent-stabilized unit, tenants moved for leave to amend their answer to add a rent overcharge counterclaim and defense, and for discovery of the rent history. The court granted the motion, holding that irregularities in the rent history are sufficient to warrant discovery and that proof of fraud is not required to obtain discovery of rent records in a rent overcharge defense.

Eva Stern 500, Llc V. Williams

All Decisions

In this nonpayment proceeding, the court granted tenant's motion for leave to reargue a prior decision denying summary judgment on tenant's rent overcharge counterclaim. Upon reargument, the court found it had overlooked binding precedent from Matter of North Carolina Leasing Corp. v New York State Div. of Hous. & Community Renewal, 156 AD2d 452 (2d Dept 1989), establishing that an overcharge may result from an owner charging less than the maximum permitted rent. Summary judgment was granted to tenant on the overcharge claim and the petition was dismissed.

Borin Kim Named Fellow Of Gerontological Society Of America, Aaron Sanborn

UNH Today Archive

No abstract provided.

When Law Watches Democracy Die: The Legal Farce Of Venezuela's 2024 Election And The Paralysis Of International Law Enforcement And Unity, Madeline Covington

International Law Journal

The 2024 Venezuelan presidential election illustrates how authoritarian regimes can undermine democracy while preserving the appearance of constitutional governance. This Article examines the historical and legal developments that culminated in the contested election, analyzes violations of Venezuela's domestic electoral framework and international legal obligations, and evaluates the international response, including sanctions, diplomatic pressure, and multilateral action. It argues that Venezuela exposes a fundamental weakness in international law: although global institutions strongly endorse democratic governance, they lack effective enforcement mechanisms to respond to electoral authoritarianism. The Article concludes by proposing institutional reforms to strengthen international accountability and protect democratic integrity.

Universal Jurisdiction And The Principle Of Subsidiarity, Michael P. Scharf, Elise Manchester, Pilar Sofia Corso

International Law Journal

In an effort to render universal jurisdiction more palatable, in recent years States have applied the so-called subsidiarity principle. Under this principle, States exercising universal jurisdiction defer prosecution of international crimes to a State which has a stronger connection to the case, normally the State where the crimes were committed or the State of nationality of the accused, provided one of those States is able and willing to pursue the case. Through a study of the statutes and caselaw of States applying universal jurisdiction, this Article seeks to discern whether subsidiarity is merely a non-binding political concept, an emerging (or …

Perpetual Statehood Among Rising Tides: The Case Of Tuvalu And The Future Of Statehood, Sovereignty, And Maritime Bounds In The Face Of Unprecedented Climate Crisis, Caroline Crawford

International Law Journal

As climate change threatens the physical existence of low-lying island nations, the question of whether a country can retain statehood without territory becomes increasingly urgent. Tuvalu, facing potential submersion by 2050, has amended its constitution to declare perpetual statehood, challenging traditional international legal definitions that link sovereignty to physical territory. This Article examines the legal implications of Tuvalu’s declaration and explores whether current frameworks, including the Montevideo Convention, selfgovernance, the presumption of continuity, the Lotus principle, and the United Nations Convention on the Law of the Sea (“UNCLOS”), can accommodate such a claim. It advocates for legal innovations such as …

Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin

Biology Faculty Works

Life is one of the most fascinating features of the physical world. Despite centuries of scientific study, experts still disagree about the definition, and even the possibility or utility of a definition, of this field. In a recent paper, we used AI to analyze the conceptual space formed by definitions of life given by a select set of modern workers in the life sciences and related fields. However, some of the most interesting material emerged as real-time conversations among those polled. In order to ensure that these ideas are not lost to the peer-reviewed scientific record, we here provide a …

Synthesis, Characterization, And In Vitro And In Silico Antibacterial Evaluation Of 5-(3-Nitrophenyl)-1, 3, 4-Thiadiazol-2-Amine, Abdelghani Sehmi, Farouk Boudou, Ahcene Keziz, Amal Belakredar, Huda Alsaeedi, Mikhael Bechelany, Gemma K. Kinsella, Ahmed Barhoum

Research Outputs: 2025-Present

Introduction – This study reports the synthesis, structural characterization, and antibacterial evaluation of 5-(3-nitrophenyl)-1, 3, 4-thiadiazol-2-amine (NPTA), a commercially available thiadiazole derivative with potential antimicrobial activity. Methods – NPTA was synthesized through a green, one-pot condensation reaction between thiosemicarbazide and 3-nitrobenzoic acid in absolute ethanol, affording a pale-yellow crystalline solid with a melting point of 110 °C–112 °C. The compound was characterized using Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy, confirming its structure. In vitro antibacterial assays, in silico ADMET and toxicity profiling, molecular docking, frontier molecular orbital (FMO) analysis, and 200 ns molecular dynamics simulations were performed. …

Marketing System Quality And Consequences: A Theoretical Extension, Christopher Agyapong Siaw

Plymouth Business School

Summary Statement.Marketing System Quality Theory (MSQT) extends the evolution of marketing thought by challenging the assumption that marketing systems inherently create positive value. Building on service-dominant logic, MSQT emphasizes the governance role of quality assurance mechanisms in shaping value co-creation across interconnected actors. The theory explains how marketing systems generate value creation, capture, destruction, and unintended consequences, and proposes evaluating marketing performance by net societal contribution.

Lgbtq+: What Utahns Need To Know, Susan R. Madsen, Deborah Lin

Marketing and Strategy Faculty Publications

LGBTQ+ Utahns who identify as girls and women thrive when they are valued and accepted for who they are. Creating environments where they feel safe, welcomed, and empowered to participate fully strengthens their health, wellbeing, and sense of belonging. Communities also benefit when LGBTQ+ women and girls are encouraged to share their perspectives, talents, and leadership. When diverse voices are welcomed into dialogue and collaborative decision-making, organizations and communities are better equipped to serve everyone. By fostering belonging, representation, and meaningful participation, Utah can create communities where every person has the opportunity to thrive.

Eating Disorders: What Utahns Need To Know, Brie Sparks, Susan R. Madsen

Marketing and Strategy Faculty Publications

Eating disorders are serious mental health conditions characterized by persistent disturbances in eating behaviors and related thoughts and emotions. They affect individuals of all ages, backgrounds, body sizes, and life stages, often occurring alongside other mental health challenges. Eating disorders can have profound impacts on physical health, emotional wellbeing, relationships, educational attainment, and workforce participation. Understanding the prevalence, risk factors, and barriers to treatment in Utah is essential for developing effective prevention, intervention, and recovery efforts.

Religious Bias In Llms Is Significantly Understudied, Sheryl Carty, Nancy Fulda, Walter Reade

Faculty Publications

In the earlier years of development of LLMs, it was relatively easy to prompt an LLM to respond with toxic or biased statements about religion. Subsequent improvements in frontier models addressed many of the issues of bias and toxicity in general, including against religion. At the same time, the adoption and usage of these models has grown exponentially. Small and implicit biases, therefore, have a magnified overall impact. In this paper, we (1) briefly review previous efforts to measure religious bias in LLMs, (2) show, by reviewing over 12,000 papers dealing with bias in LLMs, that religious bias has been …

Promoting Equity For Children And Adolescents Through Implementation Processes In Health And Social Care: A Scoping Review, Ahlia Griffiths, Amanda O'Connor, Sara Holton, Helia Khalesi, Sofia Grage-Moore, Maria Fernandez, Echezona E Ezeanolue, Allison Metz, Ana Baumann, Helen Skouteris

Faculty, Staff and Student Publications

Background: Despite the many existing implementation methods, theories, and frameworks, implementation science is insufficiently closing the research-to-practice gap. Bridging this gap is critical to achieving healthy and thriving communities globally, and requires implementation processes that promote equity and reach diverse populations, especially those most in need. The aim of this scoping review was to identify, thematically analyse, categorise, and provide examples of implementation processes described in equity-focused literature, with a focus on health and social care interventions for children and adolescents from birth to 18 years of age.

Methods: A comprehensive search of literature was undertaken across six electronic databases …

Identification Of Active Compounds And Antidiabetic Activity Of Red Shoot (Syzygium Myrtifolium) Leaves Extract With In Vitro And In Silico Methods, Muhamad Iqbal Prakoso, Siti Warnasih

Pharmaceutical Sciences and Research

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red …

How To Engage With, And Have Impact On, Marine Governance: A Practical Guide For Early-Career Researchers, Denis B. Karcher, Christopher Cvitanovic, Melanie C. Austen, Aislinn F. Dunne, Louisa Evans, Rebecca Gruby, Nicole Malinconico, Shannon Mclaughlin, E. J. Milner-Gulland, Nathalie A. Steins

School of Biological and Marine Sciences

Early-career researchers (ECRs) are at the forefront of producing the knowledge and solutions needed to address contemporary ocean challenges. Their work is often highly inter- and transdisciplinary, generating insights that are critical for informed decision-making, and effective and equitable marine governance. Yet, despite this potential for impact, many ECRs lack access to the tools, training, and institutional support necessary to engage meaningfully with governance processes. Such structural complexities are further compounded by practical constraints that ECRs experience such as short project timelines and limited networks, making engagement with governance particularly intimidating and/or difficult for ECRs. This commentary seeks to empower …

The Employment Situation Of Veterans: June 2026, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

The June 2026 Employment Situation of Veterans report from Syracuse University’s Institute for Veterans and Military Families (IVMF), based on Bureau of Labor Statistics data, highlights a softening labor market for veterans in June 2026. Veteran unemployment rose from 3.2% in May to 4.1% in June, matching the national unemployment rate but representing a notable monthly increase. Post-9/11 veterans experienced a rise from 4.1% to 4.8%. Younger veterans faced the greatest challenges, with unemployment among those ages 18–24 increasing sharply to 17.4%. Unemployment also increased among veterans ages 25–34 and 55–64. By gender, rates rose for both men and women, …

Research And Innovation Update, July 8, 2026, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.

Dwayne Reid, Jr. V. Julia Munley

2026 Decisions

USDC for the Middle District of Pennsylvania

Evaluating Cardiotoxicity And Factors Associated With In-Hospital Mortality Among Emergency Department Patients With Substance Use Disorder: An 11-Year Retrospective Study, Darpanarayan Hazra, Nadia Ahmed Said Alqusaimi, Alyaqeen Ahmed Abdullah Al Breiki, Raghad Saleh Mohammed Al Akhzami, Aya Hasan Hadi Aalhamad, Suad Abdullah Al Abri

Sultan Qaboos University Medical Journal

Objective: Substance use disorder (SUD)-related emergencies are increasing globally, with cardiotoxicity contributing substantially to morbidity and mortality. This study evaluated cardiotoxicity patterns and factors associated with in-hospital mortality among adults with SUD presenting to the emergency department (ED).Methods: This retrospective observational study was conducted from January 2014 to December 2024 at Sultan Qaboos University Hospital, University Medical City, Muscat, Oman. Adults aged ≥18 years with SUD and positive urine drug screening (UDS) were included if they had elevated troponin (>14 ng/L), electrocardiographic abnormalities or echocardiographic structural dysfunction. Clinical, laboratory, imaging, management and outcome data were analysed. Results …

Strengthening Your Ai Fluency: Building Community Resilience In An Era Of Climate Change, Suzanne Loui

Generative AI Teaching Activities

Through guided use of two AI platforms, Notebook LM and Gemini, the student will generate, analyze and evaluate ideas for implementing Pre-Disaster Hazard Mitigation and Community Resilience in a location of your choice.

Drivers Of Professional Satisfaction In Emergency Medicine Residency Training In The Us, Arvin Radfar Akhavan, Kirstin Woody Scott, Patrick Hewes, Erin Kinney, Boris Pavic, Josh Simmons, Michelle Lall, Michael Gottlieb, Yvette Calderon, Dave Lu

Department of Emergency Medicine Faculty Papers

BACKGROUND: Physician wellness discussions often center on burnout and negative aspects of clinical practice. Less is known about what brings professional satisfaction to physicians, particularly among emergency medicine (EM) residents. Understanding drivers of professional satisfaction is important for the future of the specialty as they may influence residents' career decisions. This study aimed to identify drivers of professional satisfaction among a national cohort of EM residents.

METHODS: We conducted a mixed methods study using a survey administered following the 2024 ABEM In-Training Examination to EM residents in ACGME-accredited programs. The single-item, free-text survey question asked: "List the top 3 drivers …

Risk, Trust, And Medical Decision-Making: Perinatal Care Among Patients And Providers In South Florida, Isabella Viera

Electronic Theses and Dissertations 2020 - Present

This thesis examines how structural inequality shapes the experience of perinatal care among pregnant individuals and healthcare providers in South Florida, with particular attention to how risk is perceived and communicated, how trust between patients and providers is built or eroded, and how medical decision-making unfolds under conditions of structural vulnerability. Drawing on multi-sited ethnographic fieldwork conducted between October 2025 and April 2026, supplemented by a quantitative analysis of low-birth-weight rates across all 67 Florida counties, the project analyzes how risk is defined, communicated, and lived across community-based prenatal organizations, online educational platforms, and in-depth provider and patient interviews. The …

The Sigma Ring And Other Distinctive Features Of Surface Potentials Of Group 1 Systems, Kelling J. Donald, Victoria Rankin, Brice Di Carlo, Jonathan E. Findley, Ethan B. Leonard

Chemistry Faculty Publications

For a sigma hole induced on a terminal atom, such as a halogen atom (X) in a molecule R-X, it is commonly expected that the maximum potential in that sigma hole will arise along the extension of the R-X bond, opposite the overlap region. We find, however, that for the majority of group 1 halides (MX) that expectation fails. Conventional sigma holes appear on Na in its halides and hydrides, but not so for M = K, Rb, or Cs. Instead, a sigma ring─a latitudinal ring maximum─is observed in the surface potentials of those molecules. That anomaly is examined, and …

Negotiating Poetic And Musical Structure: The Adaptation Of Pupuh Sinom In Tembang Sunda Cianjuran, Mustika Iman Zakaria Sudrajat, Yosep Nurdjaman Alamsyah

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

In the context of Sundanese culture, pupuh is a literary form that has static rules. As a literary form, pupuh is often used as a guide for composing song lyrics in Sundanese traditional vocal art, thereby leading to interactions with musical elements. In this case, this interaction happens to the pupuh Sinom, as mentioned in the lyrics of the tembang Sunda cianjuran song entitled Sinom Degung and Gawil Tarik. In this context, a negotiation occurs between the conventions of the pupuh Sinom and the song's melody, ultimately leading to the pupuh Sinom's adaptation. Using a descriptive analysis approach, …

Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz

Psychology Faculty Articles and Research

Objective. Accurate and reliable neural decoding of locomotion holds promise for advancing clinical applications such as rehabilitation and prosthetic control, as well as for understanding neural correlates of action. Recent studies have demonstrated successful decoding of locomotion kinematics across species in motorized treadmill settings. However, efforts to decode locomotion speed directly and continuously in more natural contexts—where pace is self-selected rather than externally imposed—are scarce, and those that exist generally achieve only modest accuracy and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide electroencephalography (EEG) recordings from rats. Approach. We introduce an …

Tgf-Β Drives The Conversion Of Conventional Nk Cells Into Uterine Tissue-Resident Nk Cells To Support Murine Pregnancy, Josselyn D Barahona, Liping Yang, D Michael Nelson, Wayne M Yokoyama

2020-Current year OA Pubs

Tissue microenvironments shape lymphocyte differentiation to align immune function with local physiological demands. Uterine natural killer (NK) cells are critical for reproductive success, yet the molecular cues in the uterus that instruct their specialized identities remain incompletely understood. Here, we identify a TGF-β-dependent differentiation pathway by which circulating conventional NK cells convert into uterine tissue-resident NK cells during murine pregnancy. Loss of TGF-β receptor II expression in

Um–Protoshare: Unet-Guided, Multi-Scale Shared Prototypes For Interpretable Brain Tumour Classification Using Multi-Sequence 3d Mri, Ali Golbaf, Vivek Singh, Swen Gaudl, Emmanuel Ifeachor

School of Engineering, Computing and Mathematics

Deep learning shows strong promise in brain tumour classification using Magnetic Resonance Imaging (MRI), although limited interpretability constrains clinical translation. Most interpretability methods are post-hoc and yield visual attribution maps that are only weakly connected to the decision process. Clinicians prefer decisions built from evidence they can recognise and verify on MRI, rather than post-hoc explanations. Case-based models embed reasoning by comparing image evidence with learned prototypes, yielding “this looks like that” rationales at decision time and mirroring clinical reasoning. Building on this paradigm, we introduce UM–ProtoShare, which compares the input multi-sequence 3D brain MRI with a bank of shared, …