Digital Commons Network^™

Moral Identity: From Theory To Research, Jean Paul Lefebvre

Theses and Dissertations (Comprehensive)

Moral identity, often defined as the importance or centrality of moral values to a person’s sense of self, has long been understood to play an important role in moral functioning. However, critical gaps remain regarding its development, cross-context stability, and behavioural significance. This dissertation addresses these gaps in three empirical studies, providing new insights into the nature and function of moral identity across the lifespan and in daily life.

The first study (Chapter 2) explores developmental trends in moral identity, testing predictions from moral identity goal theory (Krettenauer, 2022). Using a cross-sectional sample spanning adolescence to old age, the study …

Npr1 As A Temperature-Sensitive Regulator Of Pipecolic Acid-Mediated Plant Systemic Immunity, Spencer Tout

Theses and Dissertations (Comprehensive)

Healthy plant development requires balancing both abiotic (e.g. climate) and biotic (e.g. pathogen) challenges, which intercept important signaling pathways in plants. For example, climate change-associated elevated temperature can negatively modulate various aspects of plant immunity, including the production of central immune signals salicylic acid (SA) and N-hydroxypipecolic acid (NHP). Since SA and NHP signaling both require the master immune co-activator protein NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), it is important to investigate NPR1 as a potentially temperature-regulated molecular hub. Although the NPR1 gene is not transcriptionally downregulated at elevated temperatures (28° C vs. 23° C), little is known about …

Quantifying Ecological Processes Predicting Barren-Ground Caribou (Ɂetthën; Rangifer Tarandus Groenlandicus) Occurrence Across A Heterogenous Northern Indigenous Protected And Conserved Area., Eric Jolin

Theses and Dissertations (Comprehensive)

Northern ecosystems are experiencing a period of rapid and unprecedented change, with implications for species distributions, mammal community dynamics, and habitat associations. Understanding the ecological processes that shape species distributions is crucial for developing effective conservation strategies that can adapt to such change. This study examines drivers of barren-ground caribou occurrence, a species of cultural and ecological significance, across Thaıdene Nëné Indigenous Protected Area, an ecologically intact landscape of high habitat heterogeneity straddling the treeline of the Northwest Territories. I use spatial and temporal variation in caribou detections generated by camera traps to test the relative importance of apparent competition, …

From Cuffs To Compassion: The Impact Of Relational Policing De-Escalation Approaches On Public Perceptions Of Safety, Satisfaction, Procedural Justice, And Police Legitimacy., Brook Snider

Theses and Dissertations (Comprehensive)

Academics, policy makers, and the public have called for the prioritization of de- escalation training and use in public-police interactions to reduce police use of force (PUoF) (e.g., Dubé, 2016; Iacobucci, 2014; Todak, 2017; Wortley et al., 2021). In response to various calls to action, the Ministry of the Solicitor General launched the Ontario Public-Police Interactions Training Aid Framework in 2023, which emphasizes the importance of utilizing a relational policing approach in public-police interactions (see Lavoie et al., 2022). However, despite changes in police training frameworks, relatively little is known about PUoF in Canada (Wortley et al., 2021), with similarly …

Influence Of Temperature On Tfm Tolerance In Lake Sturgeon, Emily Bouffard

Theses and Dissertations (Comprehensive)

The lampricide, 3-trifluoromethyl-4-nitrophenol (TFM), has been used to successfully control invasive sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes for over 50 years. TFM’s effectiveness is due to the relatively low capacity of sea lamprey to detoxify TFM. Water temperature has been shown to increase TFM tolerance in larval sea lamprey. However, the effects of temperature on TFM sensitivity in non-target species such as the endangered lake sturgeon (Acipenser fulvescens) are poorly understood, particularly during their early life stages. To determine how temperature affected TFM sensitivity, age 1-year-plus (1+) lake sturgeon acclimated to 8, 16, …

From The Intimate, Regional To The Global: Examining The Indian International Student Migration To Canada, Neil Amber Judge

Theses and Dissertations (Comprehensive)

This dissertation examines Indian international student migration to Canada focusing on students from the north Indian state of Punjab, a region with extensive history of migration and transnational social ties to Canada. Punjab has historically been the predominant sending region within India to Canada, and which continues to dominate in the present phase of international student migration to Canada. The pursuit of higher education has become particularly popular in Punjab. Furthermore, Canada has recently emerged as a significant international study destination following its international education strategy aimed to attract and increase the number of international students. The study employs qualitative …

Exploring The Interconnections Between Mitochondrial Carrier Proteins Involved In Energy Transfer: The Case Of Uncouplig Proteins 2 And 4, Adenine Nucleotide Translocase, And Phosphate Translocase, Marzieh Tabefam

Theses and Dissertations (Comprehensive)

Mitochondrial carrier (MC) proteins play an essential role in cellular energy metabolism by mediating the transport of solutes and protons across the mitochondrial inner membrane (MIM). This thesis explores the structural and functional characteristics of three groups of MC proteins—Uncoupling Proteins (UCPs), Adenine Nucleotide Translocase (ANT), and Phosphate Translocase (P_iT)—to elucidate their individual and interrelated cooperative roles in mitochondrial proton transport and energy regulation.

The study develops and applies novel methodologies for the overexpression, purification, and reconstitution of MC proteins into model lipid bilayers mimicking the native mitochondrial inner membrane environment. These methods ensure proteins maintain their native-like …

Grief On The Margins: The Death Of A Family Member To Substance Use, Adair Shaw

Theses and Dissertations (Comprehensive)

Despite Canada's high death rates from substance use, there is limited research on the sociopsychological impact on families, who often face stigma and disenfranchised grief. This study explores how family members make meaning of a substance-related death. Through qualitative inquiry, eleven family members were interviewed on their experience of grief from substance death. The imprint of losing a family member to mental illness and substance use is fraught with intergenerational grief, ambiguity, prolonged mental-emotional distress, and relationship challenges. Substance death was also associated with stigma, social withdrawal, and shame for many participants. However, grievers reconstructed the socially prescribed negative perceptions …

Impact Of Membrane Lipid Composition On The Structure And Function Of Uncoupling Proteins 1 And 2 From Arabidopsis Thaliana (Atucp1 And Atucp2), Elizabeth Silva

Theses and Dissertations (Comprehensive)

A proton gradient across the inner mitochondrial membrane (IMM) is required for the synthesis of adenosine triphosphate (ATP) via ATP synthase. In other words, generation of the proton gradient is coupled to the synthesis of ATP. Interestingly, uncoupling proteins (UCPs), also located in the IMM, dissipate the proton gradient, meaning that the gradient is not efficiently used for the production of ATP.¹ The mechanism of proton transport activity of UCPs has been hypothesized and widely debated for the past 20 years to also reduce oxidative stress by reducing the production of reactive oxygen species (ROS).² The majority of …

The Divine Invitation To Co-Creation: The Effects Of Creative Practice On The Vocation Of Clergy In The Anglican Church Of Canada, Dawn Dickieson-Leger

Theses and Dissertations (Comprehensive)

Creative practice has been confirmed as having benefits for health and well-being for people as well as an effective spiritual practice aiding in discernment. Clergy find their purpose in their sense of vocation, often formed and discerned in the context of seeking ordination. The researcher, an Anglican priest and amateur artist, presents a renewed idea of vocation as co-creation with God by engaging in creative practice. Throughout the dissertation she offers reflections from her own experiences in art, health recovery, and ministry. Fifteen Anglican clergy were interviewed about their vocation, ministry, and creative practice. Each of these clergy met the …

International Students Practicing Their Wellbeing: Social Connections And Use Of Professional Mental Health Services, Lal Ruby Atesoglu

Theses and Dissertations (Comprehensive)

International students are a growing group of immigrants in Canada, and in particular in Ontario. Literature has consistently showed that international students experience unique mental health challenges, with reasons ranging from uncertainty about the future to having to cultivate social networks from scratch. Despite these stressors, they access professional mental health services at a lower rate than domestic students. Research has also shown that international students turn to their social connections to address their mental health concerns frequently. The aim of this study is to explore how international students utilize professional mental health services as well as their social connections …

Timing Of Migration And Seasonal Movements Of Arctic Grayling (Thymallus Arcticus) In Relation To Water Temperature In The Kakisa River And Upper Mackenzie River, Nwt: Results From An Acoustic Telemetry Study., Levi Snook

Theses and Dissertations (Comprehensive)

Arctic grayling (Thymallus arcticus) are a cold-water salmonid that inhabit waterbodies throughout the circumpolar regions of the northern hemisphere. In the last decade, Ka'a'gee Tu First Nation members as well as local sport fishers, have observed lower catches of Arctic grayling during their annual spawning run in the Kakisa River, NWT. Many potential causes of this decline have been hypothesized including climate change and over harvesting. Outside of the general annual spawning activity in the headwaters of the Kakisa River, the ecology of the population, including post-spawn habitat use and migratory patterns, remained understudied. To address these knowledge gaps, acoustic …

Operationalizing Intersectionality Analysis For Urban Agriculture In Quito, Ecuador, Laine N. Young

Theses and Dissertations (Comprehensive)

This thesis outlines the results of a case study in Quito, Ecuador with the municipally led participatory urban agriculture project, AGRUPAR, an internationally recognized project that promotes women’s empowerment, traditional knowledge, agroecology, and livelihoods. It works to improve the lives of those experiencing high levels of poverty in Quito. This dissertation applies an intersectional analysis to urban agriculture research to enhance attention to power relations, social justice, and equity within its scholarly and practical realms. Intersectionality is an understanding that people have unique experiences of oppression based on their unique social location (what intersecting social categories they belong to) and …

Exploring Automatic And Reflective Nudges For Smishing, Morgan E. Edwards

Psychology Theses & Dissertations

Phishing has been a common problem in the world of cybersecurity for over a decade, leading to significant monetary and privacy losses. Phishing attacks commonly occur via email, but there has been a rise in a new form of phishing known as SMiShing. This attack vector occurs similarly to email phishing, except the malicious message is received via SMS text. While ways to mitigate phishing via email have been widely studied, there is a lack of research on SMiShing and ways to mitigate this problem from a human-centered approach. Interventions such as digital nudges have been successfully applied to …

Navigating Together: The Conav Testbed And Framework For Benchmarking Cooperative Localization, Rohith Boyinine, Jayanth Ammapalli, Anusna Chakraborty, Rajnikant Sharma, Kevin Brink, Clark N. Taylor

Faculty Publications

This paper presents CoNaV, a comprehensive framework for creating a multi-vehicle cooperative localization (CL) testbed designed to support the benchmarking, development, and deployment of cooperative navigation algorithms. Given the essential role of CL in improving localization accuracy for both defense and civilian applications, CoNaV provides a robust environment for rigorously validating algorithms under real-world conditions. By establishing a benchmark for CL algorithms, CoNaV lays a foundation for advancing research into more sophisticated and distributed CL solutions. This framework highlights the potential of cooperative navigation to enhance multi-vehicle operations and offers a scalable, practical approach for future developments in CL technology.

Husbandry Of Jellyfish And Ctenophores: Why Gelatinous Forms Thrive In Their Natural Habitat And Yet Often Struggle To Survive In Aquaria, Regina Garza Ramirez

Undergraduate Theses and Capstone Projects

Recent observations in the behaviors of several gelatinous forms in the wild have demonstrated that human impacts to their environment have likely accelerated growth of their populations tremendously. Interestingly enough, population growth of jellyfish and ctenophores in aquariums and artificial habitats is less often observed under controlled conditions, while they often bloom in rapidly changing environments of nature. Seeking the knowledge of aquarists and researchers that have worked directly with gelatinous animals through interviews, and documenting the experiences of each individual, allowed acquisition of data that can be used to compare the reproductive success of these animals in captivity and …

The Space Rescue Professional: Operationalizing Guardians For The Future, Benjamin Johnis, Robert Bettinger, James Dean

Faculty Publications

The escalating competition in space exploration demands a dedicated space rescue capability. This article argues for the establishment of a space rescue professional (SRP) career field within the Department of Defense and the US Space Force. By harnessing existing US Air Force combat rescue expertise and partnering with the National Aeronautics and Space Administration, the Space Force can rapidly develop a robust SRP program with the warrant officer corps as its backbone. This article addresses a critical gap in national space policy to outline a cost-effective dual-service training pipeline and SRP operational roles. Such an investment safeguards astronauts, bolsters US …

Changes In Functional Connectivity Are Associated With Functional Independence In The Early Postoperative Period Following Awake Surgical Resection Of Language-Eloquent Glioma, Kyle R Noll, Evan D Bander, Henry S Chen, Mariana Bradshaw, Jeffrey S Wefel, Vinodh A Kumar, Sujit S Prabhu, Ho-Ling Liu

Faculty, Staff and Student Publications

Background: Neurocognitive decline in patients with primary brain tumors is associated with alterations in the functional connectome and reduced independence in daily living. This study explores postoperative connectomic changes associated with functional independence outcomes in patients with eloquent glioma, and how these associations differ from neurocognitive-connetcomic relationships.

Methods: Fifteen patients with left perisylvian glioma underwent resting-state functional magnetic resonance imaging (fMRI) and neuropsychological evaluation within 2 weeks before and on average 1 month after resection. Functional independence was measured with the Physical Self-Maintenance Scale (PSMS) and the Instrumental Activities of Daily Living scale (IADL). Graph theoretical analysis quantified functional brain …

Combining Biology-Based And Mri Data-Driven Modeling To Predict Response To Neoadjuvant Chemotherapy In Patients With Triple-Negative Breast Cancer, Casey E Stowers, Chengyue Wu, Zhan Xu, Sidharth Kumar, Clinton Yam, Jong Bum Son, Jingfei Ma, Jonathan I Tamir, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with limited targeted treatment options, heterogeneous treatment response, and high risk of early recurrence. Artificial intelligence (AI) has rapidly emerged as a powerful tool to address key clinical challenges in TNBC across diagnosis, treatment response assessment, and prognosis. Diagnostic and staging challenges persist due to variable imaging features in TNBC and limitations in conventional modalities, increasing the risk of delayed detection. Predicting response to neoadjuvant systemic therapy remains difficult, as patient responses are heterogeneous, and existing clinical markers provide limited early predictive value. Prognostication in TNBC is similarly constrained …

A Cytotoxic Peptide-Drug Conjugate For Tumor-Specific Delivery Of Co-Injected Molecules, Norio Miyamura, Chisato M Yamazaki, Yasuaki Anami, Kyoji Tsuchikama, Kazuki N Sugahara

Faculty, Staff and Student Publications

An ideal cancer therapy enhances anti-tumor effects while minimizing side effects. iRGD, a non-cytotoxic peptide that activates a tumor-specific molecular transport machinery, promotes the penetration of co-injected drugs into tumor tissues. Clinical trials have demonstrated its potential as a tumor-specific delivery scaffold and potentiator of anti-cancer agents. In this study, we synthesized an iRGD conjugate containing monomethyl auristatin F (MMAF), a highly toxic antimitotic agent, and characterized its dual function as a tumor-specific cytotoxic agent and co-injected drug delivery scaffold. The iRGD-MMAF conjugate internalized and killed cultured tumor cells in an αv integrin-dependent manner. When injected systemically, iRGD-MMAF homed selectively …

Analysis Of Cytokine Data In A Case-Control Study Of Me/Cfs, Navya Amaratunga

Electronic Theses & Dissertations (2024 - present)

This study investigated the role of cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating multi-system disease with unknown etiology. Using data from a case-control study (60 cases, 61 controls) previously collected by Dr. Roxana Moslehi’s lab, serum levels of 48 cytokines were analyzed. Statistical analyses, including T-tests, Wilcoxon Rank Sum tests, and logistic regression (unadjusted and adjusted for medication use), were performed to identify differences between cases and controls.

Results revealed a statistically significant difference in mean Fractalkine levels between cases and controls (p=0.031). Borderline significant differences were also observed for IL-6 (p=0.046) and MIP-1α (p=0.046). Unadjusted logistic regression …

Fabrication Of Functional Microparticles For Biological Analysis, Justin George

Electronic Theses & Dissertations (2024 - present)

To better advance our knowledge of cellular behavior, development of an organism, and disease mechanisms understanding cellular heterogeneity in the functional proteome is essential. Bulk measurements across a cell population often fail to capture the variations which exist between individual cells, however single cell proteomic technology has increasingly demonstrated the characterization of cellular heterogeneity. A single cell functional proteomics assay needs to be both high-throughput and multiplexed to effectively identify biomarkers and provide a quantitative correlation to better understand the interrelationships within complex protein networks. Janus particles have the ability to be engineered to have good compatibility and stability in …

The Association Of Hyperhomocysteinemia (Hhcy) With Cancer Risk: An Updated Systematic Review And Meta-Analysis Of Case-Control Studies (2013-2024), Hajar Heidari

Electronic Theses & Dissertations (2024 - present)

Abstract:

Cancer continues to be one of the leading causes of morbidity and mortality globally, influenced by a complex interplay of genetic, environmental, and nutritional factors. Among these, the metabolism of homocysteine (HCY), a sulfur-containing amino acid derived from dietary methionine, has attracted growing attention due to its involvement in one-carbon metabolism and its potential link to cancer. Elevated HCY levels, a condition known as hyperhomocysteinemia (HHCY), have been shown to disrupt crucial cellular processes such as DNA methylation and promote oxidative stress (OS)—both of which contribute to genomic instability and cancer progression. Disruptions in the folate and methionine cycles, …

Diversity, Genomics And Antimicrobial Resistance Of Coagulase-Negative Staphylococcus: A Literature Review, Kathleen Okeefe

Electronic Theses & Dissertations (2024 - present)

Members of the gram-positive bacterial genus Staphylococcus have historically been classified into coagulase-positive Staphylococcus (CoPS) and coagulase-negative Staphylococcus (CoNS). This classification is based on the ability of clotting of plasma by the coagulase enzyme, which converts fibrinogen to fibrin. CoNS species are ubiquitous commensals that frequently colonize the skin and mucosal surfaces. They are also opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS has generally been overlooked because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. They are often perceived as being less or non-pathogenic, especially compared to …

The Effects Of Mindfulness On Chronic Pain In Children And Adolescents: A Systematic Review, Sophie Parks

Electronic Theses & Dissertations (2024 - present)

Mindfulness and mindfulness-based interventions have become increasingly popular in recent years. Typically, mindfulness-based interventions and their effects on mental health and/or adult populations have been explored in the literature. Limited research has been completed looking at mindfulness’ impacts on other facets, including chronic pain symptoms. Additionally, some research has been conducted to analyze mindfulness and its effects on school aged children and their day-to-day functioning with promising results. In this systematic literature review, mindfulness interventions and their effects on children and adolescents who experience chronic pain were explored. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework was …

Antibody-Induced Multicellular Behaviors Of Salmonella Typhimurium, Samantha K. Lindberg

Electronic Theses & Dissertations (2024 - present)

Salmonella enterica is a globally distributed bacterial pathogen that is commonly acquired through consumption of contaminated food and water. The enterica subspecies includes over 1500 unique subvariants, or serovars, that are classified by antigen presentation. Due to its global environmental prevalence, broad host range, and increasing pathogenicity, serovar Typhimurium is of particular concern for human and animal health, as well as food safety. Once in the gastrointestinal tract, Salmonella Typhimurium (STm) exploits host immune mechanisms, implements an arsenal of virulence factors, and outcompetes the microbiota to invade the intestinal epithelium. While STm infections are generally self-limiting and relatively mild, emerging …

Resources To Study The Isoforms Of The P53 Family Of Transcription Factors, Dana L. Woodstock

Electronic Theses & Dissertations (2024 - present)

The p53 family of transcription factors regulates diverse gene regulatory networks such as those involved in DNA damage repair, epidermal commitment, and neuronal development. As a result, dysfunction in these pathways lead to numerous human health conditions, including multiple types of cancer and craniofacial developmental disorders. Each family member regulates a distinct gene network leading to varied cellular and organismal phenotypes, but all are capable of regulating programmed cell death, likely due to considerable similarity between protein structure and binding sites in DNA. Analysis of these shared and distinct functions is complicated by each p53 family member gene (TP53, TP63, …

Weaving A Tapestry Of Community Based Child Trafficking Interventions In High-Trafficking Incidence Areas In Ghana, Crispin Mbamba

Electronic Theses & Dissertations (2024 - present)

Background: This dissertation addresses the urgent issue of child trafficking in high-incidence areas of Ghana, where sociocultural, economic, and structural factors sustain and exacerbate this complex social challenge. The rationale for the study is grounded in the need for a holistic understanding of child trafficking beyond traditional justice-based approaches. The research emphasizes the necessity of community-led interventions informed by local cultural norms and protective values that have been largely unexplored in the Ghanaian context. Specifically, this dissertation applies an integrative approach, rooted in the Ubuntu philosophy, to explore community interdependence as a central component of sustainable anti-trafficking interventions.

Methods: …

Characterization Of Adaptive Quorum Sensing In Pseudomonas Aeruginosa, Kayla Simanek

Electronic Theses & Dissertations (2024 - present)

Pseudomonas aeruginosa is an opportunistic pathogen that is highly antibiotic resistant and causes tens of thousands of infections each year. It persists in hospitals by forming biofilms on medical equipment like ventilators and catheters, making it difficult to eradicate. Biofilm formation, among other virulence factors of P. aeruginosa, is regulated through quorum sensing, a mechanism of bacterial communication. Quorum sensing is primarily coordinated through LuxI-R type systems comprised of an autoinducer synthase and receptor, respectively. Canonically, the first system to be expressed is LasI-R, and LasR upregulates the second arm of the quorum sensing network, the RhlI-R system. Research …

The Dynamics Of Mystical Experiences: Interaction Effects And Distinct Contributions Of Meq-30 Factors, Genevieve Falabella

Electronic Theses & Dissertations (2024 - present)

Many participants in clinical trials of psychedelic-assisted therapy (PAT) report mystical experiences. Researchers often use the 30-item Mystical Experience Questionnaire (MEQ-30) to measure mystical experiences. Several studies have validated a four-factor structure of the MEQ-30, but only as a subset of items within broader versions of the scale (e.g., MEQ-43). As such, the factor structure of the standalone MEQ-30 remains unvalidated in English. Additionally, some data suggest that certain factors might be more strongly associated with psychedelic-associated outcomes than others, which could provide insight to enhance the therapeutic potential of PAT. The aim of this study was to examine the …