Digital Commons Network^™

“I’M Glad You're Alive.” Survivors’ Stories Of Leaving Intimate Partner Violence While Brain Injured, And The Embodied Experience Of Rebuilding Life And Relationships Post Violence., Robyn T. Mahood

Theses and Dissertations (Comprehensive)

Relationships are a fundamental part of the human experience, providing a buffer against stress and helping individuals live longer, happier, and healthier lives. However, survivors of intimate partner violence (IPV) who have experienced a brain injury (BI) encounter barriers to leaving violent relationships and engaging in new, non-violent connections. This qualitative research study drew from Indigenous and non-Indigenous methodologies to establish a blueprint for using storytelling in the IPV-BI population. Intersectionality theory, combined with critical disability theory, was employed as a transformative research paradigm to better analyze and explain the stories. Survivors encountered fear, trust concerns, continued violence from former …

Marine And Freshwater Habitats Used By Sympatric Anadromous Arctic Char (Salvelinus Alpinus) And Dolly Varden (S. Malma Malma) In The Central Canadian Arctic, Simon W. Depasquale Mr.

Theses and Dissertations (Comprehensive)

Two closely related but distinct species of char, Arctic Char (Salvelinus alpinus) and Dolly Varden (S. malma), are critically important to the food security and culture of Indigenous peoples in northern North America. Subsistence Inuit fishers in Kugluktuk, NU, Canada, have noticed changes in the timing and locations of their catches of char in the past ~ 10 years. In response, an ongoing partnered research program between the Kugluktuk Hunters and Trappers Organization (HTO) and scientists was formed to study Arctic Char and northern form Dolly Varden (S. malma malma). Char research near Kugluktuk presents a unique opportunity to further …

Battling Oppression And Crafting New Identities: Case Study Of The Woman, Life, Freedom Movement In Canada, Kiana Habibagahi

Theses and Dissertations (Comprehensive)

Iran’s Woman, Life, Freedom movement began in 2022, and Canada’s Iranian diaspora– the second-largest globally–continues to mobilise advocacy initiatives in its support. However, no studies have examined the movement’s implications on identity individually or collectively. These gaps fail to recognise the experiences of Iranian peoples in Canada who care deeply for the movement and have been historically marginalised. As such, using a qualitative and arts-based method, my project facilitates the retelling of experiences of young adult advocates (n = 4) in the Woman, Life, Freedom movement. Specifically, I inquired about the perceived development of their collective identities as advocates, along …

The Perceived Frequency And Effects Of Multilingual Communication In Youth And Adolescent Soccer, Simao M. Araujo

Theses and Dissertations (Comprehensive)

In professional soccer, the topic of multilingual communication has been widely researched; however, there appears to be a gap in the literature concerning how multilingual use is perceived by athletes and coaches at the youth and adolescent level of the sport. In the present study, male soccer athletes ages 10 to 18 years old and their coaches completed a questionnaire in which they rated both perceived frequency of use and perceived effects of using multilingual communication in youth and adolescent soccer. Specifically, these questionnaires elicited quantitative information regarding categories such as tactical advantages, words of encouragement, general expressions, and group …

Weight Stigma In Health-Related Undergraduate Programs, Alicia Rodney

Theses and Dissertations (Comprehensive)

Health-related undergraduate programs are common pathways for future health care providers and play a critical role in shaping attitudes toward weight, as biases formed during training often carry over into professional practice. While weight stigma (WS) has been examined among practicing professionals and medical students, little is known about how it is experienced by undergraduate students in different health-related programs, particularly across the weight spectrum. This qualitative study contributes to closing this gap by exploring and comparing how students in one kinesiology and one health sciences program experience WS within an academic setting.

Using Reflexive Thematic Analysis, open-ended survey responses …

Development Of A Stress Response Framework For Understanding Sogie Refugee Health, Arooran Saravanan Ananthavel Murugan

Theses and Dissertations (Comprehensive)

As an increasing number of individuals flee persecution on the basis of sexual orientation and gender identity expression (SOGIE), Canada has become a prominent destination for SOGIE refugees. The chronic stressors encountered by this marginalized population remain insufficiently studied, particularly in relation to physical health outcomes. This qualitative study investigates the cumulative health impacts of chronic stress among SOGIE refugees through the application of a cell-to-society framework, underpinned by Minority Stress Theory (MST). The study seeks to develop a SOGIE-specific stress response framework that theorizes the processes by which social and environmental stressors become biologically embedded, thereby contributing to elevated …

Credit Risk Modelling With Occupation Times, Hiromichi Kato

Theses and Dissertations (Comprehensive)

This thesis introduces and studies two new credit risk models: structural occupation time and occupation time hazard rate models. The defaults within the models are characterized in the form of the U.S. Bankruptcy Code Chapter 7 (a liquidation process) and Chapter 11 (a reorganization process). Structural occupation time models assume credit events are triggered as soon as the occupation time, which measures the total amount of time the firm's asset value is below a certain threshold, exceeds the grace period. Occupation time hazard rate models extend the structural occupation time models and may presume that other random factors may lead …

Measuring Technology-Facilitated Sexual Violence Victimization: Scale Development And Validation, Amanda N. Godes

Theses and Dissertations (Comprehensive)

Technology-facilitated sexual violence (TFSV) has become a prevalent form of violence recently due to the ubiquity of social media and the advancement of technology. One attempt has been made to measure TFSV victimization (TFSV-V; Powell & Henry, 2019). However, we have identified several limitations in the TFSV-V, including variability in the specificity of items, items confounding in-person experiences, items that are ambiguously worded, and the omission of critical TFSV experiences. As such, Study 1 aimed to address the limitations in the TFSV-V by revising the current measure and validating a new 18-item measure, the TFSV-Revised. Scale development methods were also …

Re-Imagining Care For Aging Disabled Adults, Caitlin L. Tizzard

Theses and Dissertations (Comprehensive)

In Ontario, the landscape of aging is shaped by ageist and ableist ideologies that view older disabled adults through the lens of decline and dependency. Much of the current discourse on aging focuses on reforming long-term care (LTC), reinforcing institutional and carceral responses both within policy and academic imagination. This qualitative study takes a different approach by asking participants how care for aging disabled adults can be reimagined beyond institutionalization. Grounded in intersectional feminist, disability justice and abolitionist praxis, and using a critical transformative paradigm, this research employed Appreciative Inquiry across three focus groups with four participants engaged in aging-related …

More Than Meets The Eye: A Phenomenological Study Of Self-Concept, Identity, And Meaning-Making In Adults With Acquired Vision Loss, Melinda M. Szilva

Theses and Dissertations (Comprehensive)

The qualitative research project examines the lived experience of acquired vision loss in adulthood and its impact on the way participants see themselves and the world around them, both sensorially and metaphorically. The research question, “What are the lived experiences of adults with acquired vision loss as they relate to identity and conceptions of self?” is informed by the researcher’s clinical practice as a psychotherapist in a low vision clinic. The dissertation includes a literature review focussed on the psychosocial aspects of vision loss to provide insight into the intended population and context for the study. Data for the phenomenological …

Comprehensive Analysis Of Environmental Particulate Matter: Chemical Composition And Microbial Assessment, Uyen T. L. Le

Theses and Dissertations (Comprehensive)

Rapid industrialization and population growth have contributed to a decline in air quality, with particulate matter (PM) posing particular concern. PM originates from both natural and human sources and often contains toxic chemicals and microorganisms, including potential pathogens. Inhalation of PM is linked to respiratory and cardiovascular diseases, underscoring the need to characterize better its chemical and biological composition in understudied region - Waterloo, Ontario, Canada. The present thesis is a culmination of three main parts. Part 1 will describe the use of the dithiothreitol (DTT) assay to quantify the oxidative potential of PM through DTT consumption of redox-active field …

A Dance Of War Or Love: Applying A Gendered Lens On The Lived Experiences Of Women Social Entrepreneurs In Nigeria, Grace C. Ihejiamaizu

Theses and Dissertations (Comprehensive)

This study explores the lived experiences of Nigerian women social entrepreneurs, using a qualitative methodology rooted in yarning circles, a culturally respectful, relational approach that foregrounds storytelling and co-construction of knowledge. Through this method, the research examines how these women navigate the intersections of gender, culture, power, and purpose within highly patriarchal and institutionally constrained environments.

The findings assert that Nigerian women social entrepreneurs are not static actors driven by fixed motivations, but dynamic changemakers whose goals shift as they gain access to resources, legitimacy, and social capital. The Cycle of Privilege framework helps us understand this evolution as an …

The Echoes Of Heartbreak: Shaping Confidence In Future Relationships Through Metaperceptions Of The Past, Anika P. Patychuk

Theses and Dissertations (Comprehensive)

Romantic relationship dissolution can be deeply destabilizing. Existing research has documented the emotional and psychological consequences of breakups but has rarely examined how these experiences shape subsequent relationship functioning. While breakups often trigger self-protective responses that can inhibit future relationship formation, individuals may also derive valuable relational insights from these experiences. The present research examined whether perceiving past romantic relationships as valuable sources of relational knowledge (epistemically valuable) enhances confidence in future romantic pursuits. I propose that perceiving past relationships as high (vs. low) in epistemic value encourages confidence in future romantic pursuits. I tested this hypothesis in three experimental …

Terpenes Mitigate Thc-Induced Working Memory Deficits: Behavioural Evidence Of The Entourage Effect Using A 2-Component Operant Memory Task, Lara Mitchell

Theses and Dissertations (Comprehensive)

Most research on cannabis and cognitive function has focused on delta-9-tetrahydrocannabinol (THC). However, this approach overlooks the complex chemical composition of cannabis products consumed by the public, which often includes cannabidiol (CBD) and various terpenes. These additional constituents may interact with THC to modulate its effects, a phenomenon known as the entourage effect. While this theory has gained traction, experimental evidence for the cognitive impact of terpenes in combination with THC remains limited. This study aimed to assess whether terpenes can mitigate THC-induced cognitive deficits using a 2-Component Operant Memory task. Male Sprague-Dawley rats received intraperitoneal injections of either …

Exploring The Role Of Collective Narcissism And Ideology In Support For Reparations, Melih Can Sahin

Theses and Dissertations (Comprehensive)

Many societies with colonial histories have begun to grapple with their legacy of historical injustices and their ongoing consequences, leading to national apologies and sometimes consideration of reparations. In this context, it is important to understand the factors enhancing or impeding public support for reparations. This dissertation focused on the role of beliefs (ideology) and identity (collective narcissism) as predictors of support for reparations addressing historical injustices. Drawing from existing research, we expected that those higher in conservatism – and those higher in collective narcissism - would oppose reparations more strongly. We also examined the interaction between ideology and collective …

Exploring The Reassessment Of Palliative Home Care Clients: A Mixed Methods Study, Maya Canham

Theses and Dissertations (Comprehensive)

Introduction: The timely reassessment of clients receiving palliative home care (HC) is critical for supporting clinicians with care planning and service delivery. However, there is little information on the frequency of reassessments and factors driving reassessment in palliative HC clients.

Objectives: The objectives of this study were to: (i) determine the proportion of palliative HC clients reassessed with the interRAI Palliative Care (interRAI PC) instrument, (ii) calculate the average interRAI PC reassessment interval, (iii) identify the key factors driving interRAI PC reassessment at various intervals, and (iv) explore the factors that influence palliative HC clinicians to reassess their clients in …

Integrating Indigenous Values And Community Strengths To Achieve Indigenous Food Sovereignty And Community Well-Being In The Ka’A’Gee Tu First Nation, Northwest Territories, Jennifer K. Temmer

Theses and Dissertations (Comprehensive)

Northern Indigenous communities face disproportionate impacts from interconnected challenges related to climate change, food security, health, and cultural preservation, that threaten traditional food systems and practices. While there is a growing recognition of the importance of community-driven solutions, existing frameworks fail to integrate Indigenous values and local priorities effectively. This research addresses this gap by exploring how the Ka’a’gee Tu First Nation (KTFN) is responding to these crises through climate change adaptation efforts focused on food system sustainability as a pathway to self-sufficiency and community well-being. To contribute to these efforts, this dissertation uses Participatory Action Research to facilitate community-driven …

Exploring The Experiences Of Racialized Immigrant Mothers In Contributing To Patterns Of Community Life In The Victoria Hills Neighbourhood, Carmel Tatiana Mahdi Miss

Theses and Dissertations (Comprehensive)

The experiences of racialized immigrant mothers are complex, nuanced, and beautiful. Oftentimes, their stories are described in a way that frames women as helpless victims, merely writing about their challenges in the absence of their protagonism. The stories in this thesis suggest that, against the obstacles unique to racialization, motherhood and immigration, mothers are often the primary caretakers of their families and play a significant role in the development of children, while creatively exploring and responding to questions pertinent to community development. They navigate community life in a place different from the one they grew up in – addressing questions …

The Body’S “Why?”: Therapists’ Embodied Approaches To Meaning-Making In Trauma And Complex Ptsd, Tanya D. Rock

Theses and Dissertations (Comprehensive)

The challenge of finding meaning in trauma is one that has inspired conversations in psychotherapeutic circles as well as amongst theologians and philosophers. Finding meaning following trauma has been positively associated with growth following the traumatic incident and has been labelled as critical to the progression of healing (Herman, 1992). This study aims to examine the role therapists play in meaning-making with clients who have experienced trauma. The research question is “how do therapists handle meaning of life challenges with traumatized clients?” Ten experienced therapists participated in this qualitative, phenomenological study. Key findings included common therapist responses to client’s “why?” …

Functional Design Of Dissymmetric Ligands For Coordination Systems, Kaitlyn R. Brown

Theses and Dissertations (Comprehensive)

Herein, the functional design of dissymmetric ligands for coordination systems is explored with a focus on their synthesis and structural characterization. The design strategy of these ligands incorporates the ability to coordinate both metal cations and anions along with a ligand site for other functionalization. Their synthesis, structural and other characterization, Hirshfeld surface analysis, and some metal-coordinated complexes are discussed. Chapter 1 introduces supramolecular and coordination chemistry, along with relevant literature that supports this research and outlines the thesis objective. Chapter 2 investigates the hydrogen bonding of a dissymmetric pyrimidine thioether ligand in its neutral form, water solvate, protonated nitrate …

The Progressive Potential Of The Horror Arg: A Digital Ethnographic Analysis Of Instagram Account Sabrinamiller230, Matthew N. Wiebe

Theses and Dissertations (Comprehensive)

Alternate reality games (ARGs) are transmedia games that exist and operate utilizing a number of digital communication platforms. These games see players employing their digital literacy skills in order to solve narrative puzzles and craft theories with other ARG players – through engaging with the alternate reality fiction presented to them. sabrinamiller230 is a horror themed ARG that takes the appearance of an Instagram profile and presents players with a speculative alternate reality world featuring an alien who critiques humanity’s many injustices. This research paper seeks to address a key problem regarding the lack of digital ethnographic studies of ARG …

“Just Checking”: Racial Profiling And The Criminalization Of Black Students At Post-Secondary Institutions, Yugita Looknauth

Theses and Dissertations (Comprehensive)

“Just Checking”: Racial Profiling and the Criminalization of Black Students at Post-Secondary Institutions

This dissertation examined the experiences of Black students who came into contact with campus security at five universities and one college in Ontario, Canada. Critical race theory and methodology, and qualitative research design amplified the voices of 17 participants who shared stories of racial profiling marked by racialization, criminalization, surveillance, and the normalized scrutiny of Black life. These experiences are legitimized by post-secondary institutions that are actively reproducing the very racism they are often celebrated for interrogating by allowing a culture of anti-Black racism to exist with …

Depression And Weight Loss Trajectories During An Integrated Behavioral Intervention: Within-Treatment Analysis Of The Rainbow Trial, Bailey W. Osweiler, Daphne Lew, Nan Lv, Jun Ma, Thomas G. Kannampallil

2020-Current year OA Pubs

INTRODUCTION: Depression and obesity are two of the most common chronic conditions among US adults. The Research Aimed at Improving Both Mood and Weight (RAINBOW) study was the first randomized clinical trial to demonstrate the effectiveness of an integrated behavioral treatment for depression and obesity. We aimed to characterize the trajectories of both depression symptoms and weight loss during the RAINBOW intervention.

METHODS: Participants (N = 201) randomly assigned to the RAINBOW treatment arm who provided serial data on depression symptoms (via the 9-item Patient Health Questionnaire [PHQ9]) and self-measured weight were included. Group-Based Multi-Trajectory Modeling is a statistical technique …

Anticodon-Edited Trna Enables Translational Readthrough Of Col4a5 Premature Termination Codons, Kohei Omachi, Joseph J. Porter, John D. Lueck, Jeffrey H. Miner

2020-Current year OA Pubs

Alport syndrome is caused by variants in COL4A3, COL4A4, or COL4A5, which encode the α3α4α5 chains of type IV collagen. These variants result in defects in the glomerular basement membrane (GBM) and impaired kidney function. Nonsense variants result in truncated proteins lacking the NC1 domain, thereby preventing proper GBM assembly and function and causing the most severe forms of the disease. Restoring full-length protein expression represents a potential therapeutic strategy for Alport syndrome and related disorders. Anticodon-edited transfer RNAs (ACE-tRNAs), which promote premature termination codon (PTC) readthrough, have shown promise in diseases such as cystic fibrosis, but their application in …

Assessing The Clinical Meaningfulness Of Slowing Cdr-Sb Progression With Disease-Modifying Therapies For Alzheimer's Disease, Sarah M Hartz, Suzanne E Schindler, Marissa L Streitz, Krista L Moulder, Jessica Mozersky, Guoqiao Wang, Chengjie Xiong, John C Morris

2020-Current year OA Pubs

INTRODUCTION: For many patients and caregivers, a major goal of disease-modifying treatments (DMTs) for Alzheimer's disease (AD) dementia is to extend independence in instrumental and basic activities of daily living (IADLs and BADLs). The goal of this study was to estimate the effect of treatments on the time remaining independent in IADLs and BADLs.

METHODS: Participants at the Knight Alzheimer Disease Research Center (Knight ADRC) who met eligibility criteria for recent DMT trials were studied: age ≥60 years at baseline, clinical diagnosis of very mild or mild AD dementia (global Clinical Dementia Rating [CDR] score 0.5 or 1), biomarker confirmation …

A Serum Biomarker Panel And Miniarray Detection System For Tracking Disease Activity And Flare Risk In Lupus Nephritis, Chenling Tang, Gongjun Tan, Aygun Teymur, Jiechang Guo, Arturo Haces-Garcia, Weihang Zhu, Richard Williams, Jing Ning, Ramesh Saxena, Tianfu Wu

Faculty, Staff and Student Publications

Introduction: Lupus nephritis (LN) leads to end stage renal disease (ESRD), and early diagnosis and disease monitoring of LN could significantly reduce the risk. however, there is not such a system clinically. In this study we aim to develop a biomarker-panel based point-of-care system for LN.

Methods: Immunoassay screening combined with genomic expression databases and machine learning techniques was used to identify a biomarker panel of LN. A quantitative biomarker-panel mini-array (BPMA) system was developed and the sensitivity, specificity, reproducibility, and stability of the were examined. The performance of BPMA in disease monitoring was validated with machine models using a …

Formulation Development Of Dual-Compartment Topical Inserts Combining Tenofovir Alafenamide And Elvitegravir For Flexible On-Demand Hiv Prevention, Vivek Agrahari, M. Melissa Peet, Neelima Chandra, Prakash Ramalingam, Pardeep K. Gupta, Sriramakamal Jonnalagadda, Onkar N. Singh, Timothy J. Mccormick, Gustavo F. Doncel, Meredith R. Clark

Department of Obstetrics & Gynecology Faculty Publications

Pre-exposure prophylaxis (PrEP) has emerged as a prominent approach for the prevention of HIV infections. While the latest advances have resulted in effective oral and injectable product options, there are still gaps in on-demand, event-driven, topical products for HIV prevention that are safe and effective. Here we describe the formulation development of a dual-compartment topical insert containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) that may be administered when needed, vaginally or rectally, pre- or post-coitus, for flexible HIV prophylaxis. Specifically, we describe the lab-scale formulation development, preclinical mucosal safety and pharmacokinetics (PK) testing in rabbits, long-term stability, and scale-up …

3d Bioprinting Technology Innovation In Female Reproductive System, Siyao Chen, Tongxin Wang, Jiaqi Chen, Mingxing Sui, Luyao Wang, Xueyu Zhao, Jianqiao Sun, Yingli Lu

Department of Obstetrics & Gynecology Faculty Publications

Several diseases affect the female reproductive system, and both disease factors and treatments impact its integrity and function. Consequently, understanding the mechanisms of disease occurrence and exploring treatment methods are key research focuses in obstetrics and gynecology. However, constructing accurate disease models requires a microenvironment closely resembling the human body, and current animal models and 2D in vitro cell models fall short in this regard. Thus, innovative in vitro female reproductive system models are urgently needed. Additionally, female reproductive system diseases often cause tissue loss, yet effective tissue repair and regeneration have long been a bottleneck in the medical field. …

In Danger: Hiv Vaccine Research And Development In Europe, Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B. Karlsson Hedestam, Hester Kuipers, Sheena Mccormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W. Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J. Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre

Department of Obstetrics & Gynecology Faculty Publications

Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has …

Association Between The Social Vulnerability Index And Adverse Pregnancy Outcomes, Tetsuya Kawakita, Misa Hayasaka, Lindsay Robbins, Juliana Martins, George Saade

Department of Obstetrics & Gynecology Faculty Publications

Objective: To assess the association between the Social Vulnerability Index (SVI) and racial disparities in pregnancy outcomes across U.S. counties and to quantify these racial disparities.

Methods: This was a cross-sectional study using restricted Centers for Disease Control and Prevention data sets, including natality data sets, fetal death data sets, and all-cause mortality data sets from 2016 to 2021. We limited analyses to Black or White individuals aged 15-44 years from 3,114 U.S. counties. Participants were categorized into quartiles based on county-level SVI. The primary outcome was maternal mortality rate while pregnant or within 42 days of the end of …