Digital Commons Network^™

Contribution Of Different Frass Fertilizer Products On Enhanced Growth, Yield And Nutrient Quality Of Broccoli [Brassica Oleracea], Noella Kagehi, Dennis Beesigamukama, Chrysantus M. Tanga, Mathew P. Ngugi, Sevgan Subramanian, Fathiya M. Khamis

All Peer-Reviewed Publications

Vegetables are crucial for food security and income, but in developing countries their production is hindered by low soil fertility. Although the insect frass fertilizer is a potential solution, its use is constrained by limited product choices. Unlike conventional fertilizers, which are available in different forms, the insect frass fertilizer is mostly available in solid form. Here, we evaluated the effects of different black soldier fly frass fertilizer (BSFFF) products on broccoli [Brassica oleracea] growth, yield, and nutritional profiles. Solid, liquid BSFFF, chitin-fortified solid BSFFF, chitin-fortified liquid BSFFF, and commercial organic fertilizer (Safi) were applied at rates equivalent to 250 …

Acceptability And Suitability Of Some Poaceae Plants For Fall Armyworm Feeding And Oviposition, Xavier Chiriboga Morales, Islam S. Sobhy, Duncan Cheruiyot, Charles A.O. Midega, Toby J.A. Bruce, Zeyaur R. Khan, Amanuel Tamiru

All Peer-Reviewed Publications

Background: The fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae), has invaded new geographical regions, now spanning Africa, Asia, Oceania and Europe, from its native distribution in the last decade. Little is known about FAW host plants in recently invaded habitats; although more than 300 hosts have been reported in the Americas, its native habitat. In our study, we evaluated the acceptability and suitability of 12 cultivated varieties of plants from Africa, in the family Poaceae, for FAW herbivory and oviposition. Methods: Experiments investigating larval development, no-choice oviposition, and no-choice larval arrestment-feeding were conducted to evaluate the insect´s ability to utilize …

The Genomic Landscape Of Hermetia Illucens: Exploring The Potential Of The Black Soldier Fly Through Molecular Insights, Peter Muchina, Johnson Kinyua, Fathiya Khamis, Chrysantus M. Tanga, Grum Gebreyesus, Zexi Cai, Goutam Sahana

All Peer-Reviewed Publications

Abstract The black soldier fly (BSF), Hermetia illucens, has garnered significant attention recently due to its potential applications in waste management, animal feed production, frass fertilizer production, and biotechnology. Despite its numerous advantages, genomic resources for BSF remain limited, underscoring the necessity for continued genomic exploration. This review provides a comprehensive overview of the genomic landscape of BSF, emphasizing the critical role of genomics in understanding its biology and optimizing its applications. We highlighted recent advancements in BSF genome sequencing, transcriptomic and proteomic studies, and the characterization of the gut microbiome, revealing its implications for BSF health and production efficiency. …

Earth Observations Reveal Impacts Of Climate Variability On Maize Cropping Systems In Sub-Saharan Africa, Adomas Liepa, Michael Thiel, Hannes Taubenböck, Doris Klein, Ingolf Steffan-Dewenter, Marcell K. Peters, Sarah Schönbrodt-Stitt, Insa Otte, Tobias Landmann, Zeyaur R. Khan, Michael Ochieng Obondo, Frank Chidawanyika, Emily A. Martin, Tobias Ullmann

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In Kenya, climate variability and change threaten smallholder, rainfed farms, with crop failures, yield reductions, and pest infestations. Efficient agroecological strategies, such as Push-Pull intercropping, offer documented benefits including pest control, improved soil fertility, and water conservation compared to traditional maize monocropping. To date, no studies exist comparing traditional maize monocropping and Push-Pull intercropping using earth observation tools over several growing seasons in East Africa. Our research addresses this by harmonizing Landsat 7, 8, 9 with Sentinel-2 remote sensing time series from 2016 to 2023. Phenological metrics of 15 growing seasons are extracted based on a threshold method using the …

Effects Of Insect Meals On Fish Digestibility, Blood Parameters, And Economic Performance: A Meta-Analysis, M. A. Aaqillah-Amr, A. Hidir, M. Ikhwanuddin, N. A. Fatan, R. Muhammad-Rahimi, S. Ning-Shahira, R. G.N. Siankhe, G. W. Vandenberg, C. M. Tanga, R. Yossa

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This review examines the use of insect meal (IM) as a substitute for fishmeal (FM) in fish feeds within the past decade. While global interest in this alternative is growing, research on its effects on fish digestibility, blood parameters, and economic performance has been limited. Meta-analysis on the apparent digestibility coefficient revealed a negative effect summary on dry matter (0.92) and crude lipid (0.51), although the difference between the two groups was relatively minor. However, a positive effect summary was reported in the apparent digestibility of crude protein (0.12), suggesting a potential advantage in the utilization of protein by fish …

Knowledge And Acceptance Of Insects As Feed Source For Poultry Production In Conflict Affected Regions Of Cameroon, Chaba F. Ambele, Ngantu Harrison, Shaphan Y. Chia, Zewdu Abro, Komivi S. Akutse, Akum E. Akumeyam, Chrysantus M. Tanga

All Peer-Reviewed Publications

Globally, insects are increasingly being considered as sustainable and complementary feeds for poultry production. However, there is a lack of information on the perception of people in vulnerable and conflict-affected communities in Cameroon. This paper presents a survey on awareness and willingness to integrate insect meals in poultry feeds in the Northwest and Southwest regions of Cameroon. During this survey, purposive and snowball sampling procedures were used to collect data from 253 households. Among those interviewed, 32% were internally displaced people and 68% residents. In general, 97% of the respondents were aware that insects are a natural food source for …

Morphometric Characterization Of Invasive Diaphorina Citri Infesting Citrus And Orange Jasmine In Ghana, Kodwo Dadzie Ninsin, Maxwell Kelvin Billah, Bernard Agyeman Boateng, Jonathan Osei-Owusu, Fred Kormla Ablormeti, Samuel Opuni-Basoa, Aboagye Kwarteng Dofuor, George Edusei, Steve B.S. Baleba, Owusu Fordjour Aidoo

All Peer-Reviewed Publications

Morphometric analysis plays a crucial role in the accurate identification and classification of insect pests, which is essential for implementing effective management strategies. The Asian citrus psyllid (Diaphorina citri Kuwayama; Hemiptera: Liviidae), an invasive species and a known vector of ‘Candidatus Liberibacter asiaticus’ and ‘Ca. Liberibacter americanus,’ the bacterial pathogens associated with Huanglongbing (HLB), has recently emerged as a pest of concern in Ghana. Despite its significance, little is known about the biological traits of field populations in the region. In this study, we examined morphometric variation in D. citri populations infesting citrus and orange jasmine (Murraya paniculata) across different …

Unpacking The Benefits Of Black Soldier Fly Frass Fertilizer Towards Nematode Suppression And Potato Production, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

All Peer-Reviewed Publications

Potato production is hindered by soil degradation and nematode infestation. Mineral fertilizers and synthetic nematicides are costly and cause negative impacts on humans and the environment, while organic fertilizers are less effective for soil health and nematode management. This study demonstrates the contribution of black soldier fly frass fertilizer (BSFFF) in nematode suppression and potato productivity when compared to commercial mineral fertilizer, organic fertilizer (SAFI), and nematicide. The on-farm experiments consisted of eight treatments: BSFFF, SAFI, BSFFF+5%chitin, NPK+nematicide, 50%BSFFF+50%NPK, 50%SAFI+50%NPK, 50%BSFFF+5% chitin+50%NPK, and control (unfertilized soil). Results revealed that all fertilizer treatments significantly increased potato growth, number of tubers (34 …

Processed Amaranth And Finger Millet Enriched With Cricket Flour Influence The Functionality, Microbial Quality, Shelf Life, And Consumer Preference Of The Porridge Products, Nelly Maiyo, Michael Okoth, George Abong, Brian O. Ochieng, Fathiya Khamis, Margaret Kababu, Chrysantus M. Tanga

All Peer-Reviewed Publications

Exploration of nutritious, cheap, and easy-to-prepare locally available complementary foods using different processing techniques is gaining traction globally. This study evaluated the impact of three processing techniques (roasting, germination, and fermentation) on finger millet and amaranth quality. The implications of blending processed products with 10% cricket flour on the functional properties, microbial safety, and shelf life of the porridge products were tested. Thereafter, consumer preference and acceptability of the cooked porridge products were assessed with randomly enrolled panelist of mothers (20–66 years), as primary caregivers. Our results showed that powder from germinated cereal products had higher swelling power, water absorption …

Mapping Global Research On Mycotoxins In Aquafeed From Scientometric And Critical Perspectives, Menaga Meenakshisundaram, Sudarshan Shanmugam, Jimmy B. Mboya, Felix Sugantham, Kevin Obiero, Jonathan Munguti, Sunday Ekesi, Sevgan Subramanian, Shaphan Y. Chia, Dennis Beesigamukama, Rodrigue Yossa, Chrysantus M. Tanga

All Peer-Reviewed Publications

The global significance of mycotoxins in aquaculture is evident. However, regional vulnerabilities, effects, and inconsistent regulations on mycotoxin contamination remain underexplored. This study integrates a scientometric analysis of research on mycotoxins in aquafeed, published from 1992 to 2023 in Web of Science, with a conventional review of their occurrence in aquafeed and feed ingredients. Bibliometric tools, VOSviewer, and biblioshiny, were used to analyze global research trends, collaborations, and themes. We found a total of 181 publications, authored by 938 researchers from 49 countries, with Brazil leading (25 publications). The Toxins journal accounted for the most publications (23). Aflatoxins, particularly aflatoxin …

Edible Insects As A Sustainable Solution To Food Insecurity In Conflict-Ridden Regions Of Cameroon, F. C. Ambele, S. Y. Chia, D. Nsobinenyui, K. S. Akutse, N. H. Ngantu, A. E. Akumeyam, M. Kababu, C. M. Tanga

All Peer-Reviewed Publications

Edible insects are integral part of traditional Cameroonian dishes and delicacies valued for their nutrition and health/medicinal benefits. This study documents indigenous knowledge, practices, cultural relevance and the willingness to explore the untapped potential of insect farming in two conflict-ridden regions of Cameroon. Semi-structured questionnaires were used to collect data from 793 randomly selected households in the Northwest (NW) and Southwest (SW) regions. Our results revealed widespread awareness on the use of insects as food in the NW (91%) and SW (84%) regions. The most consumed species were the long-horned grasshoppers (90%), termites (85%), palm weevil larvae (76%), and giant …

Is Youth's Engagement In Agribusiness An Opportunity Or A Necessity? A Closer Look At The Situation In South Kivu, Eastern Democratic Republic Of The Congo, Cool Dady Mangole, Paul Martin Dontsop Nguezet, Shiferaw Feleke, Victor Manyong, Kamala Kaghoma Christian, Zoumana Bamba, Tahirou Abdoulaye

All Peer-Reviewed Publications

Despite the broad focus on necessity- and opportunity-driven entrepreneurship in research and policy, the entrepreneurial dichotomy within the agribusiness context has not been adequately addressed. This study contributes to closing this knowledge gap by examining youth's perceptions of agribusiness through the lens of the push-pull motivation framework. Results reveal that 47% of youth are driven into agribusiness by both necessity and opportunity, while 41% by necessity alone and only 12% by opportunity alone. Key factors shaping youth's perceptions include gender, education, food processing participation, agribusiness-related training, land ownership, monthly income, and family farming background. The result further identifies significant heterogeneity …

Annual Diversity Of Honey Bee Pollen Sources In Two Pumpkin Growing Landscapes, Machakos County, Kenya, Marystella W. Nang’Oni, Muo Kasina, Rebecca Karanja, Mary M. Guantai, Rahab N. Kinyanjui, Evanson R. Omuse, Michael H.G. Lattorff, Elfatih M. Abdel-Rahman, Marian Adan, Samira A. Mohamed, Thomas Dubois

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Multi-floral foraging sources for honey bee (Apis mellifera L.) have been threatened by landscape changes and unsustainable farming practices. In East Africa, the biodiversity of forage resources that could support honey bees, especially in agricultural lands, remains least explored. This study investigated pollen diversity for honey bees in Yatta and Masinga Sub-counties in Machakos County, Kenya. Honey bee hives were installed on eight pumpkin (Cucurbita maxima Duchesne ex Lam) farms (one hive per farm) in two varying landscape vegetation classes (low and medium) based on normalized difference vegetation index (NDVI). Pollen traps were installed at the hive entrance and pollen …

Fire And Mammal Herbivory On Arthropods In The Protected Savannas: A Systematic Review, Ludzula Mukwevho, Mduduzi Ndlovu, Frank Chidawanyika

All Peer-Reviewed Publications

Protected areas in the savannas are key global reserves for biological diversity, including arthropods. Fire and mammal herbivory disrupts the diversity of biological organisms that alternately affects the functioning of the ecosystem. The study presents a global synthesis review of arthropod responses to varying intensities of fires and mammal herbivory in the protected savannas. We hypothesise that the intensity of predetermined fires and mammal herbivory has cascading impacts on abundance, species richness and diversity of terrestrial arthropods in the protected savannas. A minimum selection criteria was used to collate relevant literature from electronic databases of previous studies performed in the …

How Community Members In Uganda Perceive Controlled Human Infection Studies, Winfred Nazziwa, Stella Neema, Alison Elliot, Samson B. Kaboko, Julius Ecuru, Erisa Mwaka

All Peer-Reviewed Publications

Controlled Human Infection studies are a new and uncommon way of conducting clinical research in low resource settings. Regardless of the supposed importance of human infection studies in advancing clinical research, there is still limited literature on community perceptions of this field of research, particularly in low-resource settings. An exploratory qualitative study involving 107 community members organized into 16 focussed groups was conducted in Kampala city and Buikwe district in central Uganda between September 2023 and March 2024. The groups comprised market vendors, secondary school teachers, university students, media professionals/journalists, mosques/church attendants and Community Advisory Board members. Data were analysed …

Spatial Analytics To Elucidate The Incubation Period And Drivers Of Visceral Leishmaniasis: Case Of Turkana County In Kenya, Kennedy Senagi, Maureen Nzilani, Evans Omondi, David P. Tchouassi, Tobias Landmann, Damaris Matoke-Muhia, Emmanuel Okunga, Barrington Gesimba, Elfatih M. Abdel-Rahman, Dawn Maranga, Joseph M. Ndungu, Daniel Masiga

All Peer-Reviewed Publications

Introduction: Visceral leishmaniasis (VL) is a severe and neglected tropical disease of public health concern. VL is fatal if not treated. Kenya has experienced multiple outbreaks of the disease since 2017. The underlying drivers of the disease risk dynamics, as well as the incubation period, are not well understood. Methods: We implemented statistical (spatial logistic regression and Bayesian spatial) and machine learning (random forest, support vector machine, AdaBoost, logistic regression, and extra trees) models to estimate the incubation period and predict areas of low/high risk in Turkana County, an endemic VL foci in Kenya. Two-year (2019–2020) patient data were sourced …

Nomad: Metagenomic Characterisation Of The Viral Pathogen Composition In Outbreaks Of Non-Malaria Acute Febrile Illness Cases, Benard W. Kulohoma, Ibrahim Ng'eno

All Peer-Reviewed Publications

The clinical importance of non-malaria febrile acute illness (NM-AFI) in patients with a negative parasitological test has become apparent, with the progressive reduction in malaria transmission in endemic regions. Bacterial pathogens, for example Streptococcus pneumoniae and Haemophilus influenzae, which contribute disproportionally to febrile illness, are now preventable by vaccines. However, there are no vaccines, and little is known about viral NM-AFI prevalence, proliferation, virulence, and transmission chains between hosts. Although the predominant viral causes of NM-AFI are established, it is unclear if there are other NM-AFI associated emerging infectious viral pathogens that previously remained undetectable by conventional diagnostic strategies, for …

Do Rates Matter? Validation Of Insect Frass Fertilizer Rates In A Vegetable Intensified Push-Pull Technology For Optimal Sustainable Production, Priscilla Mwikali Kimuli, Dennis Beesigamukama, Judy Wambua, Bonoukpoe Mawuko Sokame, Chrysantus Mbi Tanga, Frank Chidawanyika, Sevgan Subramanian, Daniel Munyao Mutyambai

All Peer-Reviewed Publications

Push–pull system intensification with vegetables (VIPPT) has contributed significantly in maintaining good control of lepidopteran pests and parasitic weeds with additional food and nutritional security benefits. However, the impact of integration of different rates of black soldier fly frass fertilizer (BSFFF) in the VIPPT to enhance productivity, has not been explored. This study investigated the effects of different BSFFF application rates on growth performance, pest infestation severity, diversity of natural enemies and yield of kale (Brassica oleracea L. var. acephala) grown under VIPPT in two agroecological zones. Plants were grown in soils amended with five different levels of BSFFF (0, …

The Physicochemical Properties, Biochemical Makeup, And Health Benefits Of Honey Produced From Stingless Bees (Apidae: Meliponini), Belay Gezahegn Gebreyes, Tilahun A. Teka, Yetenayet Bekele Tola, Metekia Tamiru, Nkoba Kiatoko

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This review provides a comprehensive overview of stingless bee honey (SBH), focusing on its physicochemical properties, biochemical composition, and health benefits. SBH exhibits unique characteristics, including color, flavor, texture, and lower thermal stability, influenced by various botanical sources, stingless bee species, and diverse geographic and climatic conditions. These environmental factors, particularly floral diversity and climate, significantly affect SBH’s composition and functional properties, resulting in regional variations that impact its market value and health potential. The review details the composition ranges of SBH, which include moisture content (13.26%–41%), total acidity (12.59–270 meq/kg), reducing sugar (22.44%–78.95%), electrical conductivity (0.11–101.88 mS/cm), hydroxymethylfurfural (HMF) …

The Role Of Information And Communication Technologies-Based Extension In Agriculture: Application, Opportunities And Challenges, Kelvin Mulungu, Menale Kassie, Maurice Tschopp

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Limited access to information about new technologies is a major barrier to agricultural productivity. To bridge this information gap, agricultural extension services increasingly use Information and Communication Technologies (ICTs) to provide timely and actionable information to farmers. This systematic review analyses evidence from 49 studies examining the impact of ICT interventions including mobile apps, SMS messaging, educational videos, and voice calling services on awareness, agricultural practices adoption, yields, and income. The review reveals that 76% of studies reported increased adoption of good agricultural practices, 60% demonstrated improved awareness, 74% indicated higher yields, and 68% observed enhanced incomes. Cereals, particularly maize, …

Home Dialysis For Latinx Individuals Living With Kidney Failure: A Qualitative Study Of Interdisciplinary Dialysis Clinicians, Katherine Rizzolo, Rebeca Gonzalez Jauregui, Jade Teakell, Michel Chonchol, Sushrut S Waikar, Lilia Cervantes

Faculty, Staff and Student Publications

Key Points:

1. Individual-level advocacy to overcome structural barriers to home dialysis is key in improving home dialysis access for Latinx individuals.

2. Acknowledging patient influences on dialysis modality choice is critical for Latinx individuals with kidney failure.

3. Early, repeated education from a trusted source is important for Latinx individuals with kidney failure.

Background: Latinx individuals experience two times the incidence of kidney failure compared with non-Latinx individuals and are less likely to use home dialysis therapies. In this qualitative study, interdisciplinary home dialysis clinicians were interviewed to understand the key factors and strategies used by clinicians to improve home dialysis uptake …

Biology-Informed Inverse Problems For Insect Pests Detection Using Pheromone Sensors, Thibault Malou, Nicolas Parisey, Katarzyna Adamczyk-Chauvat, Elisabeta Vergu, Béatrice Laroche, Paul André Calatayud, Philippe Lucas, Simon Labarthe

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Most insects have the ability to modify the odor landscape in order to communicate with their conspecies during key phases of their life cycle such as reproduction. They release pheromones in their nearby environment, volatile compounds that are detected by insects of the same species with exceptional specificity and sensitivity. Efficient pheromone detection is then an interesting lever for insect pest management in a precision agroecological culture context. A precise and early detection of pests using pheromone sensors offers a strategy for pest management before infestation. In this paper, we develop a biology-informed inverse problem framework that leverages temporal signals …

Unraveling The Potential Of Black Soldier Fly Larvae As A Sustainable Protein Source For Nile Tilapia Production In Diverse Aquaculture Systems, Jonathan Munguti, Mavindu Muthoka, Jimmy B. Mboya, Domitila Kyule, Menaga Meenakshisundaram, Chrysantus M. Tanga

All Peer-Reviewed Publications

Aquaculture plays a critical role in global food security, with Nile tilapia (Oreochromis niloticus) recognized for its adaptability and robust growth. However, traditional feeds, heavily reliant on fishmeal (FM) and soybean meal, face economic and environmental challenges. In response, black soldier fly larvae meal (BSFLM) has emerged as a promising, nutrient-dense alternative. This review synthesizes existing literature on BSFLM’s nutritional profile and its suitability for Nile tilapia diets, while acknowledging that the data come from diverse independent studies conducted under varying environmental conditions and husbandry practices. BSFLM consistently provides high-quality protein (29.9%–48.2%), aligning with tilapia’s requirements, and is rich in …

Nature-Based Land Management Practices And Yield Dynamics In Oil Palm Production: Insights From Indonesian Smallholder Growers, Kibrom T. Sibhatu, Martin Paul Tabe-Ojong, Hermanto Siregar

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Nature-based land management (NLM) practices are increasingly promoted for their potential to bridge yield gaps and increase overall crop production. Yet, the extent of NLM adoption, the factors driving it, and its impact on yields remain unknown, particularly among smallholder farmers. This study addresses this knowledge gap using a unique three-round panel dataset from independent smallholder oil palm growers in Indonesia, focusing on three main NLM practices: composting, manual weeding, and organic soil amendments (SA) using lime and gypsum. We employ panel data estimators and a multivariate probit model to examine the yield effects of these practices and assess any …

Seasonal Variability Of Surface Ocean Carbon Uptake And Chlorophyll-A Concentration In The West Antarctic Peninsula Over Two Decades, Jessica S. Turner, David R. Munro, Amanda Fay, Sharon Stammerjohn, Heather Kim, Oscar Schofield, Heidi Dierssen

OES Faculty Publications

The Southern Ocean plays a vital role in global CO₂ uptake, but the magnitude and even the sign of the flux remain uncertain, and the influence of phytoplankton phenology is underexplored. This study focuses on the West Antarctic Peninsula, a region experiencing rapid climate change, to examine shifts in seasonal carbon uptake. Using 20 years of in situ air-sea CO₂ flux and satellite-derived Chlorophyll-a, we observe that the seasonal cycles of both air-sea CO₂ flux and Chlorophyll-a intensify poleward. The amplitude of the seasonal cycle of the non-thermal component of surface ocean pCO₂ increases with increasing latitude, while the amplitude …

Micrornas As Key Regulators Of Cancer Drug Resistance: Insights And Future Directions In Chemotherapy, Targeted-Therapy, Radiotherapy, And Immunotherapy, Michael Attathikhun, Ancuta Jurj, George A Calin

Faculty, Staff and Student Publications

Cancer therapy remains an active field of investigation, particularly in understanding and overcoming therapy resistance. Small non-coding RNAs, such as microRNAs (miRNAs), are emerging as key regulators of cancer survival, progression, proliferation, invasion, migration, and metastasis. Although many studies have linked miRNAs to cancer therapy outcomes, significant questions remain regarding their precise molecular and cellular roles in therapy resistance. Increasing evidence shows that miRNAs influence critical pathways such as apoptosis, immune evasion, and other signaling cascades. However, there have been many setbacks because of the limitations in knowledge of each specific miRNA's function. A deeper understanding of miRNA expression and …

Corrigendum To Exosomal Mirna Confers Chemo Resistance Via Targeting Cav1/P-Gp/M2-Type Macrophage Axis In Ovarian Cancer, Pinar Kanlikilicer, Recep Bayraktar, Merve Denizli, Mohammed H Rashed, Cristina Ivan, Burcu Aslan, Rahul Mitra, Kubra Karagoz, Emine Bayraktar, Xinna Zhang, Cristian Rodriguez-Aguayo, Amr Ahmed El-Arabey, Nermin Kahraman, Seyda Baydogan, Ozgur Ozkayar, Michael L Gatza, Bulent Ozpolat, George A Calin, Anil K Sood, Gabriel Lopez-Berestein

Faculty, Staff and Student Publications

No abstract provided.

Fraud In Genetic Testing: Swindling The System, Rachel Notestine, Claire N Singletary, Meagan Choates, Stephanie Gandomi, Molly Daniels, Rebecca Lunstroth, Quinn Stein

Faculty, Staff and Student Publications

Purpose: Health care fraud comprises a sizable portion of United States health care expenditure and inflicts undue burden on payors, patients, and the health care system overall. The genetic testing industry is rapidly growing, which propagates opportunities for health care fraud. Although federal organizations have highlighted it as an issue, there is limited research exploring genetic testing fraud.

Methods: A retrospective review of federal websites, news articles, and a legal database resulted in 42 cases of fraud involving outpatient genetic testing published between February 2019 and December 2023. These cases were analyzed for themes via inductive conventional content analysis.

Results: …

Burden Of Seasonal Human Coronavirus Infections In Hematopoietic Cell Transplant Recipients, Fareed Khawaja, Terri Lynn Shigle, Layale Yaghi, May Daher, Jeremy L Ramdial, Ella Ariza-Heredia, Ying Jiang, Roy F Chemaly

Faculty, Staff and Student Publications

Background: Community respiratory viruses, such as seasonal human coronavirus (HCoV), commonly infect hematopoietic cell transplant (HCT) recipients. Recognizing the risk factors and outcomes of HCoV infections in HCT recipients is essential for the future development of potentially lifesaving therapeutics.

Methods: We performed a retrospective review of all HCoV-infected HCT recipients from September 1, 2015 to August 31, 2017, at our institution. Patients were classified with upper respiratory tract infection (URI) or lower respiratory infection (LRI) based on predefined definitions for respiratory viral infections in HCT recipients. Patient data were collected to identify risk factors for HCoV LRI, and to calculate …

Mechanical Regulation Of Macrophage Metabolism By Allograft Inflammatory Factor 1 Leads To Adverse Remodeling After Cardiac Injury, Matthew Deberge, Kristofor Glinton, Connor Lantz, Zhi-Dong Ge, David P Sullivan, Swapna Patil, Bo Ryung Lee, Minori I Thorp, Adam Mullick, Steve Yeh, Shuling Han, Anja M Van Der Laan, Hans W M Niessen, Xunrong Luo, Nicholas E S Sibinga, Edward B Thorp

Faculty, Staff and Student Publications

Myocardial infarction (MI) mobilizes macrophages, the central protagonists of tissue repair in the infarcted heart. Although necessary for repair, macrophages also contribute to adverse remodeling and progression to heart failure. In this context, specific targeting of inflammatory macrophage activation may attenuate maladaptive responses and enhance cardiac repair. Allograft inflammatory factor 1 (AIF1) is a macrophage-specific protein expressed in a variety of inflammatory settings, but its function after MI is unknown. Here we identify a maladaptive role for macrophage AIF1 after MI in mice. Mechanistic studies show that AIF1 increases actin remodeling in macrophages to promote reactive oxygen species-dependent activation of …