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“Flies Don't Make Honey": An Exploration Of Preschoolers’ Feelings And Actions Towards Nature, Kathrin Paal Jan 2025

“Flies Don't Make Honey": An Exploration Of Preschoolers’ Feelings And Actions Towards Nature, Kathrin Paal

School of Law, Humanities and Social Sciences Theses

The burgeoning climate crisis resulting from anthropogenically enhanced global warming has made protection, restoration and affection for the environment an increasingly urgent matter. The irresponsible use of resources and pollution has caused, and will continue to cause, disastrous impacts on habitats and ecosystems globally; we urgently need to better care for the natural environment. Children’s perceptions towards nature are formed during early experiences. There is a research gap for age-appropriate methods to understand children’s perspectives whilst conceptualising them as the experts in their own lives and meaningfully enhancing their involvement in research. The aim of this thesis is to explore …


The Impact Of Socioeconomic Status On Substance Use Amongst The Hispanic Maternal Population, Emily C. Olivo Jan 2025

The Impact Of Socioeconomic Status On Substance Use Amongst The Hispanic Maternal Population, Emily C. Olivo

Honors Undergraduate Theses

Aim: To explore and synthesize existing research that focuses on the relationship between socioeconomic status and the use of substances amongst the maternal Hispanic population. By examining research and these factors, interventions can be identified to lower reported substance use rates amongst Hispanic mothers of childbearing ages.

Background: Minorities such as Hispanic women deal with a myriad of struggles, especially during motherhood. Socioeconomic status and substance use can contribute to a large part of the struggles faced by this population. Hispanic and Latina will be used interchangeably throughout this review of literature.

Method: A comprehensive electronic review of 3 databases …


An Examination Of Preservice Teacher Knowledge Of Attention Deficit Hyperactivity Disorder (Adhd) In The Elementary Classroom, Breana K. E. Webb Jan 2025

An Examination Of Preservice Teacher Knowledge Of Attention Deficit Hyperactivity Disorder (Adhd) In The Elementary Classroom, Breana K. E. Webb

Honors Undergraduate Theses

This study examines the knowledge of preservice teachers with attention deficit hyperactivity disorder (ADHD) and how well prepared they might be when supporting students in elementary classrooms. ADHD is a diagnosed neurodevelopmental disorder in children and has been increasingly diagnosed over the past several years. Teachers play a crucial role in providing effective instruction to each and every student in the classroom. Managing classroom instruction with diverse learning capabilities and behaviors requires teachers to understand the characteristics of ADHD, as well as instructional adaptations and behavioral interventions, among preservice teachers. Findings indicate that while most preservice teachers recognize the basic …


Organization And Activation Of Caffeine Expectancies, Catherine S. Forsyth Jan 2025

Organization And Activation Of Caffeine Expectancies, Catherine S. Forsyth

Honors Undergraduate Theses

Caffeine is the most consumed and widely used psychoactive substance in the world. Whether someone uses caffeine or not, expectations about use can be influential to some degree. Expectancies exist everywhere and are extremely influential in all aspects of life. Regarding drug use, expectancies can affect behavior, outcomes, and one’s experience with the drug. Caffeine is no exception, caffeine expectancies have been seen to play a role in several actions such as the development, maintenance, and reinforcement of caffeine use. This study examined latent use profiles of caffeine and relationships between the profiles and the activation of caffeine expectancies. Multidimensional …


Remedios Varo: Peregrinaciones, Julia Condes Jan 2025

Remedios Varo: Peregrinaciones, Julia Condes

Honors Undergraduate Theses

At the time of her death, the artist Remedios Varo (1908–1963) left behind over 500 works of art, the majority of which were created in her adopted country of Mexico. Known for her meticulously crafted fantastical paintings, Varo underwent exile and displacement due to first the Spanish Civil War, and later World War II, which led her to relocate to Mexico, where she would create prolifically for the remainder of her life. This paper will examine the effect of those experiences on the artist and the work she produced, attesting to Varo’s ability to translate complex emotions regarding the human …


Community Redevelopment Agencies' (Cras) Perceptions Of The Legal, Ethical, Economic, And Financial Impacts On Florida's Redevelopment Since The Passage Of Florida House Bill 9 In 2019, Laurel L. Richmond Jan 2025

Community Redevelopment Agencies' (Cras) Perceptions Of The Legal, Ethical, Economic, And Financial Impacts On Florida's Redevelopment Since The Passage Of Florida House Bill 9 In 2019, Laurel L. Richmond

Honors Undergraduate Theses

This qualitative study explores the legal, ethical, economic, and financial impacts on Community Redevelopment Agencies (CRAs) following the passage of Florida House Bill (HB) 9 in 2019 by interviewing administrators and attorneys of the oldest Florida CRAs. CRAs are dependent special districts, funded by tax increment financing (TIF), and created to address areas deemed slum, blighted, or facing a shortage of affordable housing. HB 9 intended to address transparency and accountability issues and restore CRA operations and spending back to the original purpose, as authorized by Florida Statute 169.

The findings are timely and novel, given it has been five …


Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi Jan 2025

Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi

Honors Undergraduate Theses

Suicide remains a public health concern in the U.S., particularly among individuals experiencing chronic pain and psychological distress. This cross-sectional study investigated the relationship between perceived physical and psychological pain in 41 adults with chronic orthopedic conditions. The relationship between other risk and protective factors and perceived levels of pain distress was also examined. Results showed a significant positive correlation between psychological distress and physical pain (r(39) = 0.388, p < .05) and psychological distress and depressive/anxiety symptoms (r (39) = 0.477, p < .01). Psychological distress was moderately associated with feelings of hopelessness (r (39) = 0.403, p < .01), however, the relationship between physical pain and hopelessness was weak and nonsignificant (r (39) = -0.06, p = .71). Contrary to expectations, emotional support did not buffer the effects of psychological distress (r (39) = 0.07, p = 0.66). Mediational analysis confirmed that emotional support did not influence the relationship between physical pain and psychological distress (Beta (β) = -0.969, p = 0.572; Sobel Z = 0.5598, p = 0.575). Age was not correlated with psychological distress (r (39) = -0.24, p = 0.13) or mental health symptoms (r (39) = -0.05, p = .77). While there was no significant difference across sex, males reported higher mental health symptomatology and psychological distress scores than female counterparts. These findings underscore the direct impact of physical pain on psychological distress and challenge assumptions about the protective role of social support. The study highlights the need for integrated, multidisciplinary interventions targeting both physical and psychological pain to mitigate suicide risk among individuals with chronic orthopedic conditions. Future research should iii explore alternative support mechanisms and resilience-building strategies to address the complex interplay of pain, distress, and suicidality.


Intelligent Tutoring Systems In The Age Of Llm-Based Agentic Frameworks - Adapting Small On-Device Language Models For Fact-Checking And Student Compliance Detection, Evan Vahid Naderi Jan 2025

Intelligent Tutoring Systems In The Age Of Llm-Based Agentic Frameworks - Adapting Small On-Device Language Models For Fact-Checking And Student Compliance Detection, Evan Vahid Naderi

Honors Undergraduate Theses

As large language models (LLMs) demonstrate increasingly sophisticated language understanding capabilities, they offer transformative potential for educational technology, particularly in developing more responsive intelligent tutoring systems (ITS). To develop these systems, a synthesis that balances theoretical frameworks with practical, cutting-edge, and deployable technology would be useful. This thesis aims to advance the field of ITSs theoretically by viewing the modern advancements in natural language processing within the context of the foundational frameworks important to the fields of self-regulated learning, ITSs, and cognitive agents. Then, building on prior research on the ITS MetaTutor \citep{Azevedo2022}, this research focuses on how functions of …


Physical Activity And Hypertension Outcomes Around Menopause In Adult Women—A Secondary Analysis Of The All Of Us Research Program, Meriam F. Naguib Jan 2025

Physical Activity And Hypertension Outcomes Around Menopause In Adult Women—A Secondary Analysis Of The All Of Us Research Program, Meriam F. Naguib

Honors Undergraduate Theses

Hypertension significantly impacts menopausal women due to a decrease in estrogen levels. That is due to estrogen level changes, causing many metabolic alterations, one of which is increased vascular resistance, leading to hypertension. Advanced treatments are made available to help alleviate the condition; however, lifestyle modifications—especially physical activity—show a critical role in hypertension control. This thesis explored the effect of physical activity as a non-pharmacological, lifestyle intervention on hypertension in women by menopausal status (pre-, peri-, and post-menopausal). This study used a secondary analysis with a retrospective design. Physical activity was defined using the American Heart Association's (AHA) guidelines (i.e., …


The Stigmatization Of Autism – Why It’S Still Present And How It Affects Women And Individuals Assigned Female At Birth (Afab), Emma Drauer Jan 2025

The Stigmatization Of Autism – Why It’S Still Present And How It Affects Women And Individuals Assigned Female At Birth (Afab), Emma Drauer

Honors Undergraduate Theses

The intent of this thesis is to explain some key factors (the theory of mind notion and the narrow perception of autism) that contribute to the stigmatization of autism and the impact this has on autistic women. Autistic women are heavily underrepresented, especially in the scholarly discourse, so this thesis collected first person accounts of autistic experiences through a survey and interviews. This data revealed important information such as the benefits of a diagnosis, how stigma can prevent this and have consequences, and the struggles autistic women face. Unmasking these struggles can help make the general public aware of their …


The Intersection Of Autism Spectrum Disorder And Mental Health: A Focus On College Students, Sudeepta Matha Jan 2025

The Intersection Of Autism Spectrum Disorder And Mental Health: A Focus On College Students, Sudeepta Matha

Honors Undergraduate Theses

Rising prevalence rates of autism spectrum disorder (ASD), changes in diagnostic criteria, and increased public awareness have all contributed to the growing population of college students with ASD. However, many individuals - commonly referred to as the “lost generation” - go undiagnosed, due to experiencing negative interactions with mental health professionals. As a result, these individuals are not given the proper support and interventions required for a successful transition into adulthood, and often face heightened social isolation, academic problems, mental health challenges compared to their neurotypical peers. A combination of these factors can lead to increased suicidal ideation (SI) and …


Anxiety And Adaptive Functioning In Young Adults: The Moderating Role Of Psychological Flexibility, Makenzie L. Kennedy, Jeffrey E. Cassisi Jan 2025

Anxiety And Adaptive Functioning In Young Adults: The Moderating Role Of Psychological Flexibility, Makenzie L. Kennedy, Jeffrey E. Cassisi

Honors Undergraduate Theses

Anxiety is highly prevalent among emerging adults and is associated with impairments in academic, social, and daily functioning. While previous research has documented strong associations between anxiety and adaptive functioning, the present study uniquely tested psychological flexibility as a potential moderator that may foster resilience and adaptive coping.

Undergraduate students (N = 522) from the University of Central Florida completed measures of anxiety (PROMIS-A, GAD-7, STAI-S), adaptive functioning (WHODAS 2.0), and psychological flexibility (COMPACT-23). Confirmatory factor analyses supported distinct but correlated latent constructs of anxiety and adaptive functioning. Due to poor subscale intercorrelations, the COMPACT-23 total score was modeled as …


Generation Z’S Perception Of Skin Cancer And How It Relates To Climate Change, Piercen Bogolea Jan 2025

Generation Z’S Perception Of Skin Cancer And How It Relates To Climate Change, Piercen Bogolea

Honors Undergraduate Theses

Skin cancer is the most common cancer worldwide, and climate change has been identified as a significant contributor. Preventative action early on can help reduce occurrence, but it is unknown if Generation Z is aware of this and is taking the necessary action now to protect themselves. This research aims to gauge the perception of Generation Z on the severity of skin cancer, the relationship between climate change and skin cancer, and the prevalence of preventative measures being taken. A survey was distributed to students aged 18 to 27 enrolled at the University of Central Florida through mixed sampling. The …


Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 97, Eva Armao Jan 2025

Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 97, Eva Armao

Honors Undergraduate Theses

Staphylococcus aureus (S. aureus) is a gram-positive bacterial pathogen that colonizes human nasal passages, mucous membranes, or the skin of carriers, with colonization commonly found in 20-30% of healthy people. S. aureus has the potential for two types of infection within human hosts: methicillin-susceptible (MSSA) and methicillin-resistant (MRSA). These infections can be further classified based on their route of infection, either known as community-associated (CA), healthcare-associated (HA), or healthcare-associated community-onset (HACO). Upon further investigation of infected populations, specific genetic subtypes of S. aureus, known as sequence types (ST), have been identified globally, with some exhibiting increased virulence among …


The Yeasty Rise Of Conservatism By Fermenting Sourdough, Sydney M. Mcrae Jan 2025

The Yeasty Rise Of Conservatism By Fermenting Sourdough, Sydney M. Mcrae

Honors Undergraduate Theses

Baking has become increasingly popular in the last five years, particularly baking sourdough bread. This is evident through the rise of social media influencers focusing on trad-wife, family, and sourdough content. Trad wife is the term used to describe a a woman who lives a lifestyle that endorses gender roles, child-rearing, and taking care of the family. There is significant crossover between American social conservative ideals and a trad-wife. The emblem for a tradwife has become baking sourdough since the coronavirus pandemic. Previous research has linked the correlation between American social conservatism and the increasingly popular trad-wife phenomenon. Existing literature …


Multi-Criteria Gis Suitability Analysis For Sustainable Agricultural Tourism Site Selection In Peru, Jessica J. Mccord Jan 2025

Multi-Criteria Gis Suitability Analysis For Sustainable Agricultural Tourism Site Selection In Peru, Jessica J. Mccord

Honors Undergraduate Theses

Agricultural tourism offers a mechanism to strengthen rural economies while preserving traditional practices and unique cultural identities. In the Peruvian Andes, rural communities confront increasing challenges in the face of a changing climate and reliance on industrialized agriculture. Rural communities attempt to strike a delicate balance between economic development and heritage preservation. This research utilizes a Geographic Information System (GIS)- based analysis to identify areas best positioned for the development of agritourism initiatives. The suitability analysis integrates both local and global sustainability priorities by incorporating a set of defined criteria that together identify areas that are the most appropriate for …


Identification Of Fiducial Points In Seismocardiographic Cycles Using Manual And Automated Annotation Methods, Jasmine-Vy T. Truong Jan 2025

Identification Of Fiducial Points In Seismocardiographic Cycles Using Manual And Automated Annotation Methods, Jasmine-Vy T. Truong

Honors Undergraduate Theses

There is currently a need for complementary methods for non-invasive cardiac monitoring. Seismocardiography (SCG), the measurement of cardiac-induced vibrations at the chest surface, has shown potential clinical utility. Improving the reliability of detecting fiducial points of electrocardiography (ECG) and SCG, which collectively capture the electro-mechanical cardiac activities, could expand ECG/SCG utility as a low-cost, accessible tool for clinical assessment. This study identifies commonly accepted criteria for fiducial point detection in SCG and ECG through an extensive literature review and signal processing techniques. The previous criteria were evaluated to identify their strengths and weaknesses. Based on the findings, an improved set …


Uv- Altered Macrophages: Impact Of Uv Radiation On Phagocytic Receptor Expression In M2 Macrophages And Implications For Tissue Repair And Immunosuppression, Hala Hafez Jan 2025

Uv- Altered Macrophages: Impact Of Uv Radiation On Phagocytic Receptor Expression In M2 Macrophages And Implications For Tissue Repair And Immunosuppression, Hala Hafez

Honors Undergraduate Theses

Ultraviolet radiation is an environmental stressor known to suppress immune function in the skin, but its effect on the immunoregulatory M2 phenotype macrophages is poorly studied. This study aims to investigate the impact of UV exposure on key markers of the M2 macrophage, which are critical for tissue repair and immunosuppression. THP-1 monocytes were differentiated and polarized into the M2 phenotype using Phorbol-12 myristate (PMA) and Cytokines IL-4 and IL-10. Once differentiation was confirmed, the macrophages were exposed to varying durations of UV radiation. Real Time Quantitative PCR was used to analyze expression changes in phagocytic receptors (CD206, CD163, Arg-1), …


The Petrology And Geochemistry Of The Montagna Grande-Monte Gibele Trachytic Shield Volcano (Pantelleria, Italy)., John C. White, Ray Macdonald, Pierangelo Romano, Boguslaw Baginski, Silvio G. Rotolo, Beata Marciniak-Maliszewska, Alessandra Cinquegrani Jan 2025

The Petrology And Geochemistry Of The Montagna Grande-Monte Gibele Trachytic Shield Volcano (Pantelleria, Italy)., John C. White, Ray Macdonald, Pierangelo Romano, Boguslaw Baginski, Silvio G. Rotolo, Beata Marciniak-Maliszewska, Alessandra Cinquegrani

EKU Faculty and Staff Scholarship

The 45.7 ± 1.0 ka (2σ) eruption of the compositionally zoned (comenditic trachyte to pantellerite) Green Tuff ignimbrite on the volcanic island of Pantelleria, Italy, was followed by the extrusion of a series of post-caldera metaluminous to mildly peralkaline trachyte lavas between 26.2 ± 2.0 and 22.3 ± 2.9 ka (2σ). This study uses whole-rock major- and trace-element compositions, mineral compositions, geothermobarometry, and petrogenetic models to examine the role of trachytes in the evolution of the Pantelleria magma system. Although previous studies have suggested that all of these units are consanguineous and form a liquid line of descent (LLOD) from …


When They See Us: The Lived Experiences Of Bglo Members At A Pwi, Brittany Harris-Nelson Jan 2025

When They See Us: The Lived Experiences Of Bglo Members At A Pwi, Brittany Harris-Nelson

Theses and Dissertations

This applied dissertation explored the lived experiences of members of Black Greek-Letter Organizations (BGLOs) at a predominantly White institution (PWI) in the years following the COVID-19 pandemic. BGLOs have historically served as critical spaces for leadership development, cultural expression, and community support. However, within PWIs, these organizations often encounter systemic barriers related to visibility, funding, and institutional engagement.

The purpose of this study was to center the voices of BGLO alumni who graduated between 2020 and 2024 to better understand how they navigated their membership experiences during a time of social, institutional, and cultural transition. Using a qualitative research design, …


Certain Knowledge Of Administrative Decisions Issued By Artificial Intelligence Systems In The Public Sector: A Comparative Analysis, Nayel Musa Alomran, Odai Mohammad Alheilat Jan 2025

Certain Knowledge Of Administrative Decisions Issued By Artificial Intelligence Systems In The Public Sector: A Comparative Analysis, Nayel Musa Alomran, Odai Mohammad Alheilat

All Works

This paper aims to elucidate the matter of certain knowledge pertaining to administrative decisions, those issued by artificial intelligence. It also clarifies the position of the administrative judiciary with regard to the adoption of this presumption and through a comparative analysis of administrative judicial applications in Jor-dan, Egypt, and Morocco. The text addresses the most significant evidence for achieving certain knowledge of an administrative decision – and thereby initiating the appeal period against the appellant. The question at hand is whether the administrative judiciary applies the traditional theory of certain knowledge to its counterpart issued by artificial intelligence systems, especially …


Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun Jan 2025

Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun

Plants, Soils and Climate Student Research

The western U.S. has recently experienced some of the driest conditions on record, and Utah has been in a multi-year drought (2019-2023) that affected the agricultural sector, including vegetable producers. While vegetables are not a primary agricultural crop in Utah, they are still an important part of the horticultural economy with 763 farms growing 6,138 acres. As the fourth largest acreage vegetable crop in Utah (almost 10% of the acreage) watermelon and related crops in the gourd family Cucurbitaceae (nearly 36% of total vegetable acreage) are important to vegetable growers. Watermelon is a water-intensive crop and requires an adequate supply …


Etomidate And Its Derivatives: Time To Say Goodbye?, J Robert Sneyd, Beatrijs Valk Jan 2025

Etomidate And Its Derivatives: Time To Say Goodbye?, J Robert Sneyd, Beatrijs Valk

More Faculty of Health Research

Etomidate, an intravenous hypnotic used for anaesthesia and critical care, is known for its undesirable side effects, including pain on injection, myoclonus, and adrenocortical depression. Despite its continued clinical use due to its hemodynamic stability and rapid onset and offset, alternatives like propofol, ketamine, and remimazolam offer fewer drawbacks. Recent efforts to improve etomidate through chemical modifications, such as methoxyethyl etomidate hydrochloride (ET-26), have shown limited success, with persistent issues like involuntary muscle movements and adrenocortical suppression. We suggest that it might be time to move on from etomidate and focus on developing new anaesthetic agents.


Get Remimazolam Off The Bench And Into The Game, Brian J Anderson, J Robert Sneyd Jan 2025

Get Remimazolam Off The Bench And Into The Game, Brian J Anderson, J Robert Sneyd

More Faculty of Health Research

In a high-level sporting fixture, the introduction of a skilled player from the reserve bench can be a game changer. The introduction of propofol into clinical anaesthesia practice was a pharmacological game changer [1]. The drug rapidly assumed dominance over other intravenous options for induction of anaesthesia in children. Propofol use for maintenance does not yet rival that of the inhalational agent, sevoflurane, but acceptance is increasing [2] even in areas such as neonatal anaesthesia and intensive care sedation. None of the other hypnotic drugs available or investigated have competed with propofol in adults or children [3], although remimazolam is …


The State Of Local Anaesthetic Systemic Toxicity In 2025: The Emergence Of Lidocaine As Our Next Challenge, Eric Schwenk, J Robert Sneyd, Christopher Wu Jan 2025

The State Of Local Anaesthetic Systemic Toxicity In 2025: The Emergence Of Lidocaine As Our Next Challenge, Eric Schwenk, J Robert Sneyd, Christopher Wu

More Faculty of Health Research

Local anaesthetics are an integral part of surgical and medical practice, but their systemic uptake can result in local anaesthetic systemic toxicity (LAST). A recent study by Fettiplace and colleagues examined the US Food and Drug administration’s Adverse Events Reporting System between 1968 and 2023. Although the reporting of death from longacting local anaesthetics decreased after the publication of relevant practice advisories, Fettiplace and colleagues also found that deaths from lidocaine remained essentially unchanged. The emergence of lidocaine as the leading reported cause of deaths attributable to LAST was unexpected, and the reasons behind the relatively higher number of deaths …


Palynology, Landscape And Land Use: Retrospect, Prospect And Research Agendas, Ralph Fyfe, Kevin Edwards, Laura Scoble Jan 2025

Palynology, Landscape And Land Use: Retrospect, Prospect And Research Agendas, Ralph Fyfe, Kevin Edwards, Laura Scoble

More Faculty of Science and Engineering Research

This paper provides a context for the use of anthropogenic palynology in the study of landscape and land use. Retrospective considerations indicate a history to current trends and inform future developments. Recent and prospective studies secure palynology as an essential element in archaeological and related environmental research. It is stressed that palynology is an inherently spatio-temporal discipline that can use concepts such as landscape or habitat heterogeneity as a future framework. This may be possible if recent advances in quantification of local vegetation cover, for example the use of model-based correction approaches within the Landscape Reconstruction Algorithm, are more widely …


Biomarkers In Coronary Artery Disease: Systematic Review And Meta-Analysis, Nicola King, Neil A. Smart, Theodore Bungon, Martin Peacock, Shakil A. Awan Jan 2025

Biomarkers In Coronary Artery Disease: Systematic Review And Meta-Analysis, Nicola King, Neil A. Smart, Theodore Bungon, Martin Peacock, Shakil A. Awan

Faculty of Science and Engineering Datasets

Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates. Systematic review was carried out followed by meta-analysis. The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (−0.13, 1.87), PAI-1 2.51 (−0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin −1.11 (−1.49, −0.73). Multiple biomarkers that could potentially be …


Micro(Nano)Plastics In The Fish Gastrointestinal Tract: A Mini Review And Relevance To One Health Perspective, Farhan R. Khan, Nathaniel Clark, Elvis Genbo Xu Jan 2025

Micro(Nano)Plastics In The Fish Gastrointestinal Tract: A Mini Review And Relevance To One Health Perspective, Farhan R. Khan, Nathaniel Clark, Elvis Genbo Xu

School of Biomedical Sciences

Micro(nano)plastics (MNPs) research in the piscine gastrointestinal tract has been a significant area of study. Understanding the environmental presence of microplastics, their potential for both localised and systemic effects, and their role as a gateway for MNPs and associated chemicals to enter the tissues and the food web, including the human food chain, is crucial. The fish gut, as a critical intersection between environmental, biotic, and human health, aligns with the One Health concept. We review the likely uptake mechanisms and toxicological damage caused by ingesting MNPs and their associated chemicals in fish, contextualised within the realms of digestive physiology …


Rhce Genotyping Using Next Generation Sequencing:Allele Specific Reference Sequences, Wajnat A. Tounsi, Amr J. Halawani, Kelly A. Sillence, Michele Kiernan, Neil D. Avent, Tracey Madgett Jan 2025

Rhce Genotyping Using Next Generation Sequencing:Allele Specific Reference Sequences, Wajnat A. Tounsi, Amr J. Halawani, Kelly A. Sillence, Michele Kiernan, Neil D. Avent, Tracey Madgett

School of Biomedical Sciences

BackgroundThe Rh blood group system (ISBT004) is encoded by two homologous genes, RHD and RHCE. Polymorphism in these two genes gives rise to 56 antigens, which are highly immunogenic and clinically significant. This study extended previous work on the establishment of RHD allele specific reference sequences using next generation sequencing (NGS) with the Ion Personal Genome Machine (Ion PGM) to sequence the complete RHCE gene.Study Design and MethodsGenomic DNA (gDNA) samples (n = 87) from blood donors of different serologically predicted genotypes including R1R1 (DCe/DCe), R2R2 (DcE/DcE), R1R2 (DCe/DcE), R2RZ (DcE/DCE), R1r (DCe/dce), R2r (DcE/dce), R0r (Dce/dce), rr (dce/dce), r'r …


Comparative Evaluation Of Swabbing Sites For Omicron Variant Detection In Pcr Testing, Tom Fowler, Edward Blandford, David Chapman, Matthias E Futschik, Raghavendran Kulasegaran-Shylini, Sarah Tunkel, Carolyn Lewis, Alasdair Fellows, Ellie Sheppard, Leanne Mccabe, Peter Marks, Paul E Klapper, Andrew Dodgson, Malur Sudhanva, Mike Kidd, Andy Vail, Susan Hopkins, Tim Peto Jan 2025

Comparative Evaluation Of Swabbing Sites For Omicron Variant Detection In Pcr Testing, Tom Fowler, Edward Blandford, David Chapman, Matthias E Futschik, Raghavendran Kulasegaran-Shylini, Sarah Tunkel, Carolyn Lewis, Alasdair Fellows, Ellie Sheppard, Leanne Mccabe, Peter Marks, Paul E Klapper, Andrew Dodgson, Malur Sudhanva, Mike Kidd, Andy Vail, Susan Hopkins, Tim Peto

School of Biomedical Sciences

PURPOSE: The Omicron variant of SARS-CoV-2 raised concerns about the best sampling sites for PCR testing, with early indications suggesting throat swab samples were better than nasal swab samples. Our study evaluated the sensitivity of detecting SARS-CoV-2 across different swabbing sites.

METHODS: Participants undergoing testing at NHS Test and Trace sites in England provided self-collected samples using nose only, throat only, and combined nose and throat swabs, which were analysed by realtime PCR.

RESULTS: Among 815 participants, combined swabs had higher viral concentrations than nose only or throat only swabs. Sensitivity for detecting SARS-CoV-2 by PCR was 91 % for …