Digital Commons Network^™

Targeting Mertk On Tumour Cells And Macrophages: A Potential Intervention For Sporadic And Nf2-Related Meningioma And Schwannoma Tumours, Kevin Herrera Keane

Peninsula Medical School Theses

Although schwannomas and meningiomas are generally benign and slow-growing, the mass effect of either tumour within the nervous system causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment for large or symptomatic schwannomas and meningiomas is surgical resection, which may not be suitable in cases involving tumours located near sensitive neuroanatomy or clinically vulnerable individuals. Not all schwannomas and meningiomas respond to alternative targeted treatments such as stereotactic radiosurgery or the vascular endothelial growth factor inhibitor bevacizumab. The main objective of this thesis was to investigate targeting of the receptor tyrosine …

Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Barrett Mcclean

All Faculty Scholarship

For more than a decade, Dred Scott was enslaved by a U.S. Army officer in a military system that perpetuated the institution of slavery in the free states and Northern territories of the antebellum period. Scott’s life, his lawsuit for freedom, and the U.S. Supreme Court case holding that Black people have “no rights which the white man was bound to respect” became infamous. But the history of the Dred Scott case and the military’s use of enslaved persons is largely unknown. Drawing on reparations advocacy in the Rosewood and Tulsa race massacre cases and other historical precedent for reparations, …

Spatiotemporal Patterns Of Desertification Sensitivity And Influencing Factors Across The Western Inner Mongolia Plateau, China, Yang Chen, Long Ma, Xixi Wang, Tingxi Liu, Zixu Qiao

Civil & Environmental Engineering Faculty Publications

Desertification remains a critical global ecological and environmental challenge that threatens sustainable development. Although our understanding of desertification dynamics and their underlying drivers has improved, continued research is needed due to the region-specific nature of these processes. This study focuses on the Western Inner Mongolia Plateau in China as a case study to examine the evolution of desertification and its driving factors using a multifaceted approach, including the Mediterranean Desertification and Land Use (MEDALUS) model. Results show that the desertification sensitivity index (DSI) across the plateau ranged from 1.12 in prairie regions to 1.87 in desert areas, with a spatial …

Scientists’ Statement On The Chemical Definition Of Pfass, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

The undersigned are scientists with expertise in per- and polyfluoroalkyl substances (PFASs) and/or the management of chemicals. We assert that the Organization for Economic Co-operation and Development (OECD) definition of PFASs is scientifically grounded, unambiguous, and well suited to identify these chemicals. We are concerned that some individuals and organizations are seeking a redefinition of PFASs endorsed by the International Union of Pure and Applied Chemistry (IUPAC) to exclude certain fluorinated chemical subgroups from the scope of the existing definition. We are concerned that this effort is politically and/or economically, rather than scientifically, motivated. An IUPAC-endorsed and potentially narrower PFAS …

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

The bioaccumulation of per- and polyfluoroalkyl substances (PFAS), both legacy and novel, in the environment presents significant ecological and health risks. PFAS are a diverse group of synthetic chemicals known for their persistence and bioaccumulation, which can cause widespread environmental contamination and health risks. Strong carbon-fluorine bonds give these compounds unparalleled stability, preventing them from degrading and enabling them to endure in a range of environmental matrices, including water, soil, and biota. Legacy PFAS, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been extensively studied and regulated, resulting in lower concentrations in some environmental media. However, novel PFAS, …

Rebuttal To “Correspondence On ‘Scientists’ Statement On The Chemical Definition Of Pfass”, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

No abstract provided.

Furthering The Capabilities Of Diffusive-Gradient Passive Samplers For Per- And Polyfluoroalkyl Substances, Jarod Snook, Jitka Becanova, Simon Vojta, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are chemical pollutants of growing concern for many stakeholders. Due to their ubiquity, persistence in the environment, and potential for toxicity at low environmental concentrations, it is necessary to have convenient and reliable methods to measure PFAS in natural waters. Passive sampling methods (in situ preconcentration of PFAS) may be suitable for monitoring situations. One passive sampling design successfully employed for other, well studied contaminants (e.g., methylmercury) is the diffusive gradient in thin film sampler (DGT). However, the application of DGT for PFAS requires development and validation. Here, we iterate on previous PFAS-DGT studies by …

Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos

Graduate School of Oceanography Faculty Publications

The concept of regulatory capture has been extensively studied in academic literature, primarily within the social sciences. This phenomenon has been increasingly discussed in the environmental sciences as the impacts of regulatory capture on human and ecosystem health have become increasingly apparent. Regulatory capture is just one tactic employed by vested interests in the strategy of delaying, weakening, or abolishing policies designed to protect the public interest. Here, we define capture strategies as ‘the act of influencing individuals, organizations, or governments to prioritize corporate interests over those of human and ecosystem health’. Similar to the evolution of terms like whitewashing …

Achievements And Challenges With Equilibrium And Kinetic Passive Sampling Of Hydrophobic And Hydrophilic Organic Compounds In Surface Waters, Kees Booij, Rachel Mackie, Branislav Vrana, Rainer Lohmann, Sarit L. Kaserzon

Graduate School of Oceanography Faculty Publications

Passive sampling in surface waters is an important method in the monitoring and risk assessment of hydrophobic and hydrophilic organic chemicals. Sampler designs can be optimized for fast equilibrium attainment (equilibrium sampling) or improved time-integrative capability (kinetic sampling). We argue that both equilibrium and kinetic sampling can be applied when aqueous concentrations do not vary with time, whereas kinetic sampling also yields useful results for time-variable concentrations that are often observed with hydrophilic compounds in surface waters. We show that these methods have similar accuracy in principle but that their dominant error sources are different: sampler-water sorption coefficients for equilibrium …

Pfas In Drinking Water, Wastewater And Surface Water In Reykjavik, Iceland, María J. Gunnarsdóttir, Hrund Ó. Andradóttir, Kristín Ólafsdóttir, Ásta Ósk Hlödversdóttir, Roland Kallenborn, Erik Magnus Ræder, Jan Ludvig Lyche, Jitka Becanova, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with global environmental and health implications. This study evaluated PFAS concentrations in drinking water, wastewater, and surface water in Reykjavik, Iceland, focusing on seasonal variability and potential pollution sources. Thirty-three samples from groundwater, wastewater, and surface water were analysed for up to 54 PFAS. Results reveal that PFAS concentrations in Reykjavik's drinking water were minimal, which most compounds below detection limits, and the sum of 18 PFAS below 0.5 ng L⁻¹. These levels were significantly below EU Drinking Water Directive and European Food Safety Authority health limits, indicating effective source …

Changes In Pyrogenic Tracers Over The Last 15,000 Years In The Congo River Catchment Through Multi-Method Analysis, Samuel D. Katz, Helena Osterholz, Riley Barton, Ellen R.M. Druffel, Xiaodong Gao, Caroline A. Masiello, Cristina Santin, Tassiana S.G. Serafim, Sasha Wagner, Matthias Zabel, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Black carbon (BC), the most recalcitrant part of the pyrogenic carbon continuum, is formed by the incomplete combustion of biomass and fossil fuels. Methods for detecting BC include the chemical degradation of condensed aromatic compounds into benzenepolycarboxylic acids (BPCA), chemothermal oxidation of organic carbon at 375°C (CTO), ¹³C nuclear magnetic resonance combined with a molecular mixing model, thermogravimetry-differential scanning calorimetry, and the use of polycyclic aromatic hydrocarbons as tracers. However, there is limited knowledge about the comparability of these methods in marine sediments and their suitability as wildfire proxies. Here, we examined a sediment core from the Congo River …

Atmospheric Concentrations Of Per- And Polyfluoroalkyl Substances In Michigan's Ambient Air Using Passive Sampling, Melissa Woodward, Jitka Becanova, Simon Vojta, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

As a part of Michigan's efforts to identify and address per- and polyfluoroalkyl substances (PFAS) contamination statewide, more knowledge of atmospheric PFAS concentrations is needed to better understand their atmospheric transport and impact on other environmental media. This research aimed to measure atmospheric concentrations of PFAS in Michigan's ambient air using low-cost and easy-to-use passive samplers and identify relationships with environmental factors. Passive samplers, consisting of polyurethane foam (PUF) discs and sorbent-filled polyethylene tubes (radiello-XAD samplers), were deployed for a month at 27 sites across Michigan and analyzed for both ionic and volatile, neutral PFAS. Short chain perfluorocarboxylic acids (PFCAs), …

Perfluorinated Carbon Chain Length Drives Uptake Of Diverse Per- And Polyfluoroalkyl Substances In Field-Deployed Passive Samplers, Matthew Dunn, Jitka Becanova, Simon Vojta, Heidi Pickard, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are a group of compounds of high concern due to their ubiquity, persistence, and adverse health impacts. With a diversity of chemical structures and properties, detection tools are needed to capture as many PFAS as possible. In this study, a microporous polyethylene tube (MPT) passive sampler was calibrated for 25 target compounds, 8 suspect PFAS, and extractable organofluorine (EOF) during 1–2 week deployments in groundwater, freshwater river, and estuary contaminated by aqueous film-forming foam (AFFF). Targeted analysis, suspect screening, and EOF were performed on passive and grab samples to derive sampling rates, R_s. …

Characterization Of The Potential Long-Term Impact From Sedimentary Pfas At A Historically Contaminated Textile Waste Site, Jarod Snook, Jitka Becanova, Simon Vojta, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are pervasive pollutants at historically contaminated sites throughout the United States and beyond. Two such sites in Rhode Island, USA, are textile-mill-associated waste retention ponds known to introduce PFAS contamination to the adjacent river, estuary, and eventually the Atlantic Ocean. Here, we thoroughly investigated the retention ponds as a long-term source of PFAS via water passive sampling, sediment coring, and laboratory-derived partitioning coefficients, K_d, with field sediment and water. Additional studies were performed to assess the mobility and estimate the mass fluxes of PFAS from sediment to water. Retention pond 1 was more …

Final Cruise Report: Tn401, Roxanne A. Beinart, Shawn Arellano, Craig Young

Graduate School of Oceanography Faculty Publications

No abstract provided.

Resort Enhances Reference-Based Cell Type Deconvolution For Spatial Transcriptomics Through Regional Information Integration, Linhua Wang, Ling Wu, Guantong Qi, Chaozhong Liu, Wanli Wang, Xiang H-F Zhang, Zhandong Liu

Duncan NRI Faculty and Staff Publications

Motivation: Spatial transcriptomics (ST) captures positional gene expression within tissues but lacks single-cell resolution. Reference-based cell type deconvolution methods were developed to understand cell type distributions for ST. However, batch/platform discrepancies between references and ST impact their accuracy.

Results: We present Region-based Cell Sorting (ReSort), which utilizes ST's region-level data to lessen reliance on reference data and alleviate these technical issues. In simulation studies, ReSort enhances reference-based deconvolution methods. Applying ReSort to a mouse breast cancer model highlights macrophages M0 and M2 enrichment in the epithelial clone, revealing insights into epithelial-mesenchymal transition and immune infiltration.

Availability and implementation: Source codes …

Drosophila Models Uncover Substrate Channeling Effects On Phospholipids And Sphingolipids In Peroxisomal Biogenesis Disorders, Michael F Wangler, Yu-Hsin Chao, Mary Roth, Ruth Welti, James A Mcnew

Duncan NRI Faculty and Staff Publications

Peroxisomal Biogenesis Disorders Zellweger Spectrum (PBD-ZSD) disorders are a group of autosomal recessive defects in peroxisome formation that produce a multi-systemic disease presenting at birth or in childhood. Well documented clinical biomarkers such as elevated very long chain fatty acids (VLCFA) are key biochemical diagnostic findings in these conditions. Additional, secondary biochemical alterations such as elevated very long chain lysophosphatidylcholines are allowing newborn screening for peroxisomal disease. In addition, a more widespread impact on metabolism and lipids is increasingly being documented by metabolomic and lipidomic studies. Here we utilize Drosophila models of pex2 and pex16 as well as human plasma …

Recurrent Carotid Paragangliomas In A Syndromic Patient With A Heterozygous Missense Variant In Dna Methyltransferase 3 Alpha, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, Lisa Saba, Robin Fletcher, Matthew L Tedder, Bekim Sadikovic, Jennifer Kerkhof, Michael Wangler, Carlos A Bacino

Duncan NRI Faculty and Staff Publications

We report a 40-year-old African American female with a novel variant in exon 8 of DNA methyltransferase 3 alpha (DNMT3A), (NM_022552.4: c.905G>C, p.G302A) who presented with a history of recurrent carotid paragangliomas, mediastinal mass, intellectual disability, dysarthria, cholelithiasis, diabetes mellitus, hypertension, and dysmorphic features. We interpret this novel variant as likely pathogenic and causative for the patient's syndromic features of Heyn-Sproul-Jackson syndrome. Heyn-Sproul-Jackson syndrome is a condition caused by gain-of-function genetic changes in DNMT3A. Paragangliomas have also been observed in non-syndromic patients with genetic alterations in DNMT3A. We describe a patient with clinical features of Heyn-Sproul-Jackson syndrome such as …

The Use Of Motivational Interviewing In Preventing Dental Caries Among Young Children, Denise C. Mckinney, Melissa L. Sullivan, Futun Alkhalifah

Dental Hygiene Faculty Publications

Dental caries is a complex, preventable disease that remains a global health burden. The burden of this disease has been shown to impact young children before the age of 6 years. Discussing dental caries prevention with the mother/caregiver(s) prior to childbirth is an ideal time to influence positive oral health behaviors. Motivational interviewing (MI) is a person-centered, goal-oriented, collaborative communication style that has been used to help individuals modify behaviors. The interrelated principles of partnership, acceptance, compassion, and evocation underpin the MI approach while utilizing communication skills such as asking open-ended questions, affirmation, reflective listening, and summarizing (OARS) to engage …

Examining Low-Income Caregivers' Knowledge And Comprehension Of The Dental Caries Process, Melissa Sullivan, Denise C. Mckinney, Deanne Shuman, Qi Zhang

Dental Hygiene Faculty Publications

Purpose Dental caries among young children remains a public health concern in the United States (US). Children of caregivers with low oral health literacy (OHL) tend to have greater unmet dental needs and poorer oral health status. The purpose of this study was to examine the understanding of pediatric dental terms associated with the dental caries process among low-income caregivers.

Methods This study included 14 caregivers with children enrolled in a Special Supplemental Nutrition Program for Women, Infants and Children (WIC) in the Southeastern US. Through structured phone interviews, the validated Oral Health Literacy Inventory for Parents (OH-LIP) was used …

Advances In Ocean Mapping And Nautical Cartography, Giuseppe Masetti, Ian Church, Anand Hiroji, Ove Andersen

Center for Coastal and Ocean Mapping

The Special Issue of Geomatics on "Advances in Ocean Mapping and Nautical Cartography" addresses emerging methodologies, technologies, and applications in ocean mapping. This collection includes studies on the development of high-resolution seabed mapping techniques, innovative data processing for marine cartography, and advancements in hydrographic surveying. It highlights the importance of integrating geospatial data from sources such as remote sensing, autonomous underwater vehicles, and satellite-based observations. Additionally, articles discuss challenges and strategies for ensuring data accuracy and accessibility, reflecting a growing interest in sustainable marine resource management and navigation safety enhancements.

Western Gulf Of Maine Acoustic Assessment Reference Sites, Larry G. Ward, Rachel C. Morrison, Michael Bogonko

Center for Coastal and Ocean Mapping

Four “reference sites” were established in 2023 in the Western Gulf of Maine (WGOM) for the specific purpose of testing and evaluating acoustic systems (i.e., sub-bottom seismic profilers) by the University of New Hampshire (UNH) Center for Coastal and Ocean Mapping and Joint Hydrographic Center (CCOM/JHC). Determination of the reference sites was guided by a detailed understanding of the surficial geology and shallow subsurface stratigraphy based on an extensive database developed over several decades by UNH. The reference sites include a high-energy channel deposit (Portsmouth Harbor Entrance: PHE), a large sand shoal (Northern Sand Body: NSB), a paleodelta (Merrimack Paleodelta: …

Unh/Noaa Joint Hydrographic Center 2025 Performance And Progress Report Executive Summary, Larry A. Mayer

Center for Coastal and Ocean Mapping

No abstract provided.

Unh/Noaa Joint Hydrographic Center 2025 Performance And Progress Report Executive Summary, Larry A. Mayer

Center for Coastal and Ocean Mapping

Reporting Period: 01/01/2025–12/31/2025

From The Archives: Leadership And The Professional Ethic

Journal of the American College of Dentists

Each issue of the Journal of the American College of Dentists (JACD) features an archival article selected for its continued relevance to contemporary issues in dentistry. This article provides historical context and enduring insights that inform current discussions in the profession.

The Dark Side Of Leadership: Finding Where You Belong, Bo Yu Dds, Phd, Steven Milgazo Ba, Ms, Elizabeth O. Carr Dha, Facd (Hon), Sreenivas Koka Dds, Ms, Phd, Mba, Mas, Facd

Journal of the American College of Dentists

Leadership—whether as a parent, healthcare provider, soldier, or business executive—requires intentional effort to master its art and science. Just as we would not expect a physician or a soldier to learn their craft entirely “on the job,” we should not expect leaders to develop their leadership skills the same way. Society demands years of preparation for physicians and soldiers before they assume their professional responsibilities. However, when it comes to leadership, we often accept that individuals take on leadership roles with neither formal leadership training nor the “education of experience,” despite the profound and life-changing consequences of good and bad …

Ethical Frontiers In Dentistry: Navigating Artificial And Augmented Intelligence, Robert A. Faiella Dmd, Mmsc., Mba

Journal of the American College of Dentists

The dental profession is continually evolving, and the emergence of artificial and augmented intelligence presents both transformative opportunities and critical challenges. Artificial intelligence generates automated outputs, and augmented intelligence synergistically integrates human expertise with machine-derived insights to enhance clinical judgment and decision-making. The terms will be used interchangeably here, abbreviated as AI.

The Ethical Dilemma Of Social Media, Janet H. Southerland

Journal of the American College of Dentists

Technology and digital communication have radically altered how we communicate and interact. As a consequence, the ethical use and application of technology within the profession, particularly the utilization of social media, is essential to preserving and upholding the tenets of professional conduct across dentistry.

From The Archives: Ethical Problems In Dental Practice

Journal of the American College of Dentists

Each issue of the Journal of the American College of Dentists (JACD) features an archival article selected for its continued relevance to contemporary issues in dentistry. This article provides historical context and enduring insights that inform current discussions in the profession.

J Am Coll Dent 2025 91 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.