Digital Commons Network^™

Anti-Inflamatory Mechansim Of Bacillus Subtilis Derirved Exopolysaccharide, Adrian Taylor Ibarra

Dissertations

Exopolysaccharides (EPS) secreted by the commensal bacterium Bacillus subtilis exhibit potent anti-inflammatory properties, yet the underlying molecular mechanisms remain incompletely understood. We hypothesized that EPS reprograms antigen-presenting cells toward a tolerogenic state by modulating TLR4–MyD88 signaling. To test this, we began using a chemically defined, high-yield EPS production and purification protocol that largely eliminates protein and DNA contaminants, thus improving functional reproducibility across experiments using this new method. In vitro, EPS engaged TLR4 on murine dendritic cells (DC2.4) without inducing classical NF-κB activation, seen by LPS stimulation. Rather, EPS treatment upregulated inhibitory molecules, PD-L1 and PD-L2 while leaving activation markers, …

Investigating The Mechanism Of Resistance To Ido1 Enzyme Inhibitor Treatment In Human Glioblastoma, Kyla Shivakumar Hatton

Dissertations

Glioblastoma (GBM) is the most common and most aggressive form of adult cancer in the central nervous system, with GBM accounting for the majority of all malignant brain tumors. GBM is currently considered to be an incurable form of cancer, with over 14,000 patients diagnosed in the United States last year. Given the success of immunotherapy for treating other types of cancer, our group has investigated the possibility of therapeutically neutralizing immunosuppressive indoleamine 2,3 dioxygenase 1 (IDO1) in patients with GBM. Canonically, IDO1 is an immunosuppressive cytoplasmic enzyme that catalyzes the first step in metabolizing L-tryptophan into L-kynurenine (ie. ↓L-Trp→↑L-Kyn). …

Developing Chemically Defined Serum-Free Medium For Leukemic Blast And Stem Cell Expansion, Carmen Eva Finley

Dissertations

The relapse and chemotherapy resistance are the major challenges of acute myeloid leukemia (AML) treatment, driven by a rare population of leukemia stem cells (LSCs). LSCs are unique types of cells which evade standard chemotherapies and can regenerate AML post-treatment. Targeting LSC therapy remains limited, in part due to the lack of reliable in vitro AML culture systems to grow LSCs for drug discovery. This study aimed to engineer a chemically defined, serum-free 2D in vitro culture condition that supports either the expansion of leukemic blasts (LBs) or primary human LSCs by optimizing current protocols for hematopoietic stem cells (HSCs) …

Investigating Whether Txnrd2 Is A Therapeutic Target Against Triple Negative Breast Cancer Using African American-Derived Models, Keacha Chang

Dissertations

Despite similar breast cancer incidence rates, African American (AA) women experience a 40% higher mortality rate compared to Caucasian American (CA) women. This disparity is multifactorial and particularly pronounced in the Chicago area. AA women are twice as likely to be diagnosed with triple-negative breast cancer (TNBC), often at a younger age and with more aggressive disease. TNBC is a heterogeneous subtype lacking targeted therapies and is associated with the poorest prognosis among breast cancer types. Therefore, there is an urgent need for novel therapeutic strategies for TNBC, especially those tailored to AA patients. The thioredoxin pathway is essential for …

Examining Secretory Pathways In Inflammasome Activated Innate Immune Cells, Alejandra Castellanos Urquidez

Dissertations

Innate immune cells serve as the first line of defense by detecting pathogens through pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Recognition of PAMPs triggers the synthesis and secretion of pro-inflammatory proteins, with the inflammasome playing a key role in the secretion of interleukin-1β (IL-1β), a crucial part of the innate immune response. Upon inflammasome activation, the release of signal-peptide lacking cytoplasmic proteins such as IL-1β occurs through non-classical pathways known as unconventional protein secretion (UCPS), which vary depending on the cell type and stimulus which helps tailor the extent of pro-inflammatory protein secretion. Broadly, UCPS cargoes are released …

Capturing Diverse Adolescents’ Social Contexts: The Development Of An Ethnic-Racial Microaffirmations Scale For Peer Interactions, Maria Radulescu

Dissertations

The development of a strong and positive sense of ethnic-racial identity (ERI) has been identified as an asset for ethnically and racially marginalized adolescents. Peer interactions during the adolescent years can support ERI development. In particular, a subtle micro-level form of peer support—microaffirmations—may be protective for ERI processes. However, the field of microaffirmations is very small, and there is no scale that captures adolescents’ experiences of ethnic-racial microaffirmations from their peers. The current study developed an ethnic-racial peer microaffirmations scale based on extant literature and feedback from 4 focus groups with 22 sophomore high school students. Findings indicated that 5 …

“What’S Happening In The Gulf Of Maine?”: Middle School Students’ Engagement In Climate Science Through Data Visual Representation And Reflections, Grace Ocular

Dissertations

This study examined how middle school students engaged with science concepts while working with data visualizations during a field trip learning experience. Fifty-one teams of 2–4 students from 35 schools participating in the LabVenture program were video- and audio-recorded. Students completed two activities: one using a frequency table of marine species illustrating threats to Maine’s lobster population, and another using maps depicting changes in Gulf of Maine sea surface temperature. After each activity, students annotated the visualization, discussed their claims, and recorded short reflections. Transcripts were coded for science-related talk, and annotations and gestures were also analyzed. Findings indicate that …

The Bacterial Sensing Nuclear-Oligomerization Domain 2 Receptor In The Brain: Location And Potential Function, Julia Smyth

Dissertations

Nucleotide-binding oligomerization domain-2 (NOD2) is a cytosolic receptor, activated by bacterial peptides that initiates innate immune responses through nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and Caspase-1 pathways. While the role of NOD2 in inflammation outside the central nervous system (CNS) is well-established, especially in the gastrointestinal system, its expression and function in the brain remain poorly defined. Previous genetic studies suggest a link between NOD2 and neurological and psychiatric conditions, including stroke, Parkinson’s disease, and schizophrenia. However, information regarding NOD2 expression, localization, and function in the CNS is limited. In this work, we investigated NOD2 expression, localization, and regulation …

Evaluation Of Bacteriophage Infection Of Enterococcus Faecalis In A Monolayer, Alexandria Osborn

Dissertations

Enterococcus faecalis is one of the first colonizers of the human gastrointestinal tract, and it plays a role in the intestinal immune development at the very early stages of life. However, it is also an opportunistic pathogen, capable of translocating across the mucosal barrier to cause systemic infections. E. faecalis is also linked to infections including endocarditis, recurrent urinary tract infections (rUTIs), bacteremia, wound infections, meningitis, root canal infections, intra-abdominal and pelvic infections, and septicemia. Persistent enterococcal opportunistic infections have been associated with the production of virulence factors and sharing of antibiotic resistance genes, thus making E. faecalis difficult to …

Keep It In Your Pants: How Sexual Regulation Becomes Identity Regulation, Madelyn Shoemaker

Dissertations

White Evangelicalism has been studied quantitatively for many years; however, this article examines in-depth interviews with ex-congregants of a specific church located in Chicago. Building from Orit Avasai’s framework of “doing religion,” I argue that due to a high saturation of isolation, sexual regulation and patriarchal power, this specific church’s script of religious performance claims master status in individual identity building, leading to adverse effects in adulthood. Much of the rhetoric utilized to justify the intense regulation of identity mirrors that of the New Right movement of the 1980’s, as well as modern political discourse. This study will assist in …

"I'M Not Having Fun Anymore": A Qualitative Analysis Of Gender And Harassment In Bars And Clubs, Phoebe Marie Jackson

Dissertations

Sexual harassment, while often spoken about in hushed tones or ignored altogether, happens frequently and often loudly. 66 percent of women who have experienced sexual harassment report that the harassment took place in a public space, such as work, school, or on the street (Kearl, 2018). Harassment is not discreet, but rather normalized, and those who experience it are expected to brush it off or take it in their stride. However, such harassment and subsequent dehumanization has a deteriorating effect on the mental well-being of those affected (Graham et. al., 2016). This study aims to hone in on the effect …

Effects Of Nitrogen, Phosphorus And The Fungicide Azoxystrobin Additions On Larval And Post-Metamorphic Fitness Of American Toads (Anaxyrus Americanus), Michael Vosburgh

Dissertations

Since European settlement, vast areas of U.S. land have been modified by humans. In the Midwest, an estimated 99% of native grasslands have been replaced by agriculture and urban development. Such alternations have replaced native habitat, redefined hydrology and introduced a wide array of chemicals into aquatic ecosystems. Modern agricultural practices utilize fertilizers and pesticides to maximize crop production. These chemicals frequently runoff into surrounding waters, potentially effecting aquatic organisms. One group of organism thought to be susceptible to agricultural contaminants are amphibians. Amphibians are vulnerable to pollution due, in part, to their permeable skin and biphasic life history. Global …

Systematic Review Examining How Black Youth In The United States Cope With Stressful And Traumatic Experiences, Marcus Aaron Flax

Dissertations

Coping is an important behavioral skillset that youth use to emotionally regulate after experiencing stress or trauma. Research has repeatedly highlighted the stressors that Black youth experience, often finding that Black youth face higher levels of stress and trauma than their White peers. However, there has been a lack of research in understanding how Black youth cope with these higher levels of stress. This systematic review includes 72 studies (N = 16,205 participants) examining the frequency and effectiveness of coping strategies used by Black youth in response to a trauma or stressor, along with the associations between utilized coping strategies …

Voices Of Chinese American Emerging Adults: Complex Racial Identities, Family Dynamics, And Mental Health Experiences, Maxwell Lou Xu

Dissertations

Although Asian Americans are the fastest growing racial minority group in the United States, they remain significantly underrepresented in mental health research. Furthermore, research on Asian American mental health often aggregates the experiences of different Asian ethnic groups, creating a limited understanding of how distinct ethnic groups may differ in their mental health experiences. This interview study with Chinese American emerging adults ages 18–25 from varied family contexts (single-race, multiracial, and adoptive households) examines how members of this population make sense of the relationships between their identity, family, and mental health. This thesis posits that Chinese Americans' nuanced experiences—particularly around …

Experiences And Perceptions Of Gaslighting In The Workplace, Lauren Flanagan

Dissertations

The topic of gaslighting has gained increasing traction over the last several years. People have begun researching it in real-world settings such as relationships, politics, and the workplace. Furthermore, researchers have looked at the effects it has on the victim. However, there has been limited research on how one might react to an instance of gaslighting. This study examines how the victim’s race and the perpetrator’s position of power influence third parties’ recommendations on how to handle a scenario of workplace gaslighting. Psychology 101 students (N = 154) were randomly assigned to a 2 (race of victim: white vs black) …

Ultramodern Racism: A Critical Discourse Analysis Of The Impact Of Anti-Crt Legislation On Us History Curriculums, Amelia Gernand

Dissertations

In the wake of Donald Trump’s failed 2020 bid for a second presidential term, there was a surge in anti-CRT legislation targeting how issues of race and racism could be taught in public school curricula. While proponents claim that anti-CRT laws will protect students of all races from discrimination, curriculums have historically been used as a tool by those with symbolic power to legitimize white supremacy and perpetuate anti-Black and color-evasive racism. Two states--Florida and Arkansas--recently enacted anti-CRT legislation in addition to Black history mandates. While legislators in these two states claim that their goal is to expand the teaching …

The Forced Sterilization Of Quechua-Speaking Women In Peru: The Role Of Epistemic Injustice In The Perpetration Of Genocide, Geraldine Diaz

Dissertations

The forced sterilization of Quechua-speaking women in Peru from 1996 to 2000 represents a case of genocide in which the state as an epistemic agent has a fundamental role. Although the systematic sterilization was carried out under the guise of a family planning program, the targeting of these women provides strong circumstantial evidence of genocidal intent. According to the testimonies of these women, medical staff, acting on behalf of the government, performed tubal ligation procedures through coercion, threats, lies, bribery, manipulation, and other tactics where the state intentionally withheld information, misinformed women, and failed to obtain proper consent. This research …

Response Of Benthic Macroinvertebrate Community Structure And Aquatic Insect Secondary Production To Coarse Woody Debris Addition In Peri-Urban To Urban Golf Course Ponds, Ryan Johnson

Dissertations

Golf courses represent 29% and 26% of all greenspace areas in the U.S. urban regions and the Chicago metropolitan region, respectively; however, they are often overlooked among urban greenspaces as a tool to mitigate the impacts of increased urbanization on ecological communities. The primary aim of this research was to assess whether manipulating golf course pond habitats by adding coarse woody debris (CWD) would enhance aquatic invertebrate community structure and secondary production, with the potential to increase local biodiversity. One pond in each of six golf courses was selected for this study and sampled in summer 2020 before wood addition …

Aspiration To Achievement: A Mixed Methods Study Of Post-Secondary Access For Firstgeneration College Students, Traveon L. Jefferson

University of the Pacific Theses and Dissertations

This mixed-methods study examines the effectiveness of Destination Diploma, a community-based post-secondary access program, in supporting the college readiness, enrollment, persistence, and completion of first-generation college students (FGCS). Grounded in Social Capital Theory, the study explores how structured support systems—such as mentorship, academic coaching, and financial aid navigation—enhance educational outcomes for students historically underrepresented in higher education. Quantitative data from 2014 to 2024 was analyzed to assess post-secondary placement and completion rates, while qualitative data from semi-structured interviews with former program participants provided insight into the lived experiences and perceived impact of the program. Findings demonstrate that Destination Diploma plays …

Editor's Note, Marites Tiongco

DLSU Business & Economics Review

No abstract provided.

Episodes In Computing History - Salon Talk, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

This talk (first given in 2004) presents a concise overview of key developments in the history of computing. It begins with early methods of counting and recordkeeping, such as tally sticks and the Inca quipu. It then traces the evolution of numeric systems, including Roman and Hindu-Arabic notation, and the mathematical contributions of figures like Al-Khwarizmi. Mechanical computing devices such as the abacus, Napier’s bones, and the Pascaline are examined, along with the Jacquard loom and its use of punch cards.

The talk continues through the rise of electronic computing, highlighting milestones such as ENIAC, the work of Alan Turing, …

Alteration Of Fit In Soft Milled Cobalt-Chromium And Zirconia Fixed Dental Prostheses After Ceramic Veneering, Elie Daou

Annual Research Symposium

No abstract provided.

From Disciplinary Enthusiasm To Soulless Tasks: Norms Behind Computing Educators' Emotion Display, Virginia Grande, Päivi Kinnunen, Matthew Barr, Anne Kathrin Peters, Mihaela Sabin, Matilde Sánchez-Peña, Ethel Tshukudu

Faculty Research, Scholarly, and Creative Activity

Computing educators' emotion display is regulated by various norms and conventions. These (unwritten) rules affect which emotions educators feel comfortable expressing to different extents when students can perceive such displays. We draw on emotions and norms literature to investigate higher education computing educators' perceptions of what kinds of norms they have as criteria when considering which emotions they are (not) comfortable showing when teaching. Based on the qualitative content analysis of 22 interviews with computing educators from seven countries, we present various–sometimes connected or conflicting–norms that influence emotion display. These norms comprise moral, national, societal, professional, and affiliation norms that …

Urban Coyotes As A Source Of Conflict With Humans: An Evaluation Of Common Management Practices, Paul D. Curtis, David L. Bergman, Angeline Barker, Daniel Bogan, Mary Ann Bonnell, Pierre Canac-Marquis, David Drake, Dave Kay, Brian F. Wakeling, H. Bryant White

Human–Wildlife Interactions Monographs

Wildlife often serves as a catalyst for conflict among stakeholders. Management actions that are intended to address sources of disagreement may initiate additional conflict. The Association of Fish and Wildlife Agencies Human–Wildlife Conflict Working Group initiated an effort to identify management actions commonly used to address unwanted coyote (Canis latrans) interactions within urban environments and identify the benefits and challenges associated with each action. Challenges with coyotes in urban environments include aggressive behavior toward humans and pets, attacks, disease exposure, and domestic livestock damage. Although elimination of all attractants would prove preventative in most instances, in practice this …

Cultivating Community-University Partnerships Within The Chicago Region Food System, Hanan Abdillahi, Vivian Cossey, Tania Schusler, Kevin Erickson, Karen Schauwecker, Sarah Ku, Ray Dybzinski

School of Environmental Sustainability: Faculty Publications and Other Works

We interviewed 22 organizations in the Chicago Regional Food System to gain insights on their current initiatives, assets, challenges, future visions, and perceived roles of universities in advancing their work. We analyzed themes to report on strong consensus or varied perspectives related to this work. This report aims to advise Loyola’s School of Environmental Sustainability's future work and collaboration activities with Chicago Food System organizations.

The Effect Of Social Hierarchy And Captivity On Behavior In Cercopithecus Petaurista, Haley Bombard

Undergraduate Scholarship and Creative Works

The social hierarchy within three Cercopithecus petaurista individuals was studied to determine how the influence of captivity affects behavior. The three individuals were monitored from August-November, and the data retained was focused on aggression and allogrooming behaviors. The group consisted of one dominant male and two females in the Central Florida Zoo, and behavioral observations were recorded at 10-minute intervals. Results showed that the dominant male infrequently engaged in allogrooming behavior but more often received it from the less dominant females. The hierarchy and social status of the females was shown and influenced by the allogrooming given and received between …

Homeschooling And Online Learning Technologies From A Parent’S Perspective, Karla M. Forti

Theses and Dissertations

The purpose of this quantitative, predictive correlational research study was to examine the relationship between homeschooling parents’ use of educational technology tools and their instructional behaviors and perceptions, with additional consideration of virtual school participation. Survey-based data from 22 parents of over 40 homeschooled children were used to examine technology adoption and instructional preferences across non-traditional learning settings. The study addressed four research questions through descriptive statistics and correlational analysis, while quantitative themes from open-ended responses enriched the findings. Results provided insight into parental motivations and trends influencing homeschooling and virtual school choices, highlighting the expanding role of online learning …

Overcoming Challenges In Obtaining And Presenting Evidence In Federal Sex Trafficking Prosecutions, Jason Brumbelow

Theses and Dissertations

Sex trafficking is a complex and under-prosecuted federal crime (Cook, 2019). Misunderstandings about how this exploitation happens can “frustrate the criminal justice response to trafficking” (Murphy, 2022, p. 4). Investigating and prosecuting the crime of sex trafficking includes understanding concepts such as consent and coercive control. Proving these concepts within the federal criminal justice system is not straightforward (Albanese et al., 2022).

This study will examine the challenges law enforcement professionals face in identifying and putting forth the elements of force, fraud, and coercion in federal sex trafficking investigations and prosecutions. Investigating and prosecuting the crime of sex trafficking requires …

“A Bond As Strong As A Lock And Chain”: Youth Of Color In Low-Income Communities Use Photovoice To Theorize Developmentally Nurturing Processes Of Their Cross-Age Mentoring Programs, Kevin M. Miller, Katherine Tyson Mccrea, Victor Sarna, William Donnelly, Grace Ann Fitzgibbons, Jamie Kessler, Cynthia Onyeka, Chana Matthews, Maryse Richards, Elijah Daniels, Dreyce Denton

Social Work: School of Social Work Faculty Publications and Other Works

Youth of color experiencing low-income in the United States face multiple human rights violations: over-policing, community violence, racial discrimination, and insufficient voice in the programs and policies that impact their current and future lives. To accomplish transitional justice, participatory processes are needed that elicit youths’ cultural strengths and wisdom about themselves, their social conditions, services they find helpful, and why those services are helpful. This study highlights findings from a photovoice that elicited youths’ perspectives about a crossage mentoring out-of-school-program. Responding to “What does mentoring mean to you?” 147 youth took photographs in their communities and wrote narratives about the …

Self-Efficacy Is Not Just About The Self: African American Cross-Age Youth Mentors, Amzie Moore, Maria Wathen, Katherine Tyson Mccrea, Maryse Richards

Social Work: School of Social Work Faculty Publications and Other Works

Objective: Self-efficacy, a belief in one’s capacity to achieve specific outcomes despite obstacles, is tied to a myriad of positive outcomes in the educational, relational, mental health, and future achievement of Black youth. Black youth living in racially segregated, low-income urban communities face greater obstacles than other youth. This study examines how participation as mentors in a cross-age mentoring program influences self-efficacy, and what social and environmental factors are related to changes in self-efficacy

Method: The study employs growth-curve analyses to investigate the impact of participation on self-efficacy and to examine the effects of the strength of the mentor-mentee relationship, …