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Artificial Intelligence Should Get To Play Games Too: Large Language Models Playing Picobot And Generative Artificial Intelligence As A Teaching Assistant, Jonathan J. Wise Jan 2025

Artificial Intelligence Should Get To Play Games Too: Large Language Models Playing Picobot And Generative Artificial Intelligence As A Teaching Assistant, Jonathan J. Wise

CMC Senior Theses

This thesis identifies strengths and weaknesses of Large Language Models

(LLMs) in a game-based, academic computer science setting. Specifically, it builds a

platform for LLMs to compete on a foundational assignment for entry-level Computer

Science students: playing the game of Picobot. To enable the analysis, it reconstructs

an earlier Picobot simulation: translating from Python2 to Python3, and introducing an

LLM mode that interacts with the Application Program Interfaces (APIs) of multiple

classes of LLMs.

We find that, while the LLM models understand the existence of the Picobot

game, the LLMs require specific instructions to generate valid moves. Therefore, this

thesis …


Transnational Legal Violence: Undocumented Women V. U.S. Immigration Law, Luis A. Mendoza Jan 2025

Transnational Legal Violence: Undocumented Women V. U.S. Immigration Law, Luis A. Mendoza

CMC Senior Theses

This thesis examines how undocumented women, particularly Latinas, experience "transnational legal violence" within the U.S. immigration system. Transnational legal violence extends the framework of legal violence by identifying how immigration policies weaponize absence and distance across national boundaries, forcing women to choose between physical safety and legal recognition. The thesis is guided by a central question: What immigration system are migrant women, specifically Latinas, responding to?

The analysis rooted in the intersections of gender and citizenship reveals how immigration law remains rooted in coverture traditions that historically rendered immigrant women dependent on male U.S. citizens. For these women, deportation presents …


Adaptive Evolution Shapes The Transmissibility Of West Nile Virus In New York State, Sean M. Bialosuknia Jan 2025

Adaptive Evolution Shapes The Transmissibility Of West Nile Virus In New York State, Sean M. Bialosuknia

Electronic Theses & Dissertations (2024 - present)

Arthropod-borne viruses (arboviruses), which are maintained in nature in complex transmission cycles involving hematophagic invertebrates and their vertebrate hosts, are the cause of a significant and expanding global health burden. Defining arbovirus-host interactions is necessary if we are to understand the adaptive and epidemiological potential of arboviruses. The results presented with West Nile virus (WNV Flaviviridae: Orthoflavivirus), are a compilation of such studies. WNV is the most prevalent arboviral pathogen in the U.S. and the most geographically distributed arbovirus in the world. Despite the evolutionary potential of these RNA viruses, WNV and other arboviruses have experienced only limited …


Social Capital And American Democracy: How The Digital Age Has Created Challenges For Social Cohesion In America, Walsh Kern Jan 2025

Social Capital And American Democracy: How The Digital Age Has Created Challenges For Social Cohesion In America, Walsh Kern

CMC Senior Theses

This thesis examines the connection between social capital and politics in the context of American democracy. I begin by showing how society and government have been deeply linked since the political theories of Plato and Aristotle. I maintain that these philosophers conceptualized politics as a reflection of social conditions. Next, I demonstrate how Tocqueville builds on this tradition in his assertion that American democracy rose out of the nation’s unique equality of conditions and strong social bonds. With the understanding that civil society is crucial to American democracy, I then show how this fundamental pillar has been deteriorating. I present …


Gold And Glory The Fate Of Hungary’S Lost Treasures After World War Two, Gwenivere M. Robinson, Gwenivere M. Robinson Jan 2025

Gold And Glory The Fate Of Hungary’S Lost Treasures After World War Two, Gwenivere M. Robinson, Gwenivere M. Robinson

CMC Senior Theses

This thesis examines Hungary’s national identity and Cold-War diplomacy through the fate of two major cultural treasures: The Holy Crown of St Stephen and the Hungarian Gold Train (Werfen Train). By tracing the history of the Holy Crown from its origin myths and evolving role alongside the changing concept of Kingship the study shows how it became a crucial aspect of national identity and legitimacy not just for leaders but for the Hungarian people. By analyzing the seizure, mishandling and prolonged American custody of the Gold Train, this thesis exposes a different dimension of American postwar literature by showing a …


Donald Trump's Digital Media Campaign: How Podcasts Shaped The Political Views Of Young Men, Natalie Teare Jan 2025

Donald Trump's Digital Media Campaign: How Podcasts Shaped The Political Views Of Young Men, Natalie Teare

CMC Senior Theses

This paper investigates the increase in Donald Trump’s young male voters in the 2024 presidential election through his digital media campaign. Trump was a guest on over 15 podcasts and livestreams, almost exclusively hosted by men. This paper examines three podcasts to discover what techniques Trump used to appeal to male voters: Impaulsive with Logan Paul, This Past Weekend with Theo Von, and The Joe Rogan Experience. The demographic of young men has specific interests, fears, and challenges that affect the strategies politicians use to garner their support. The advents of social media and podcasting have allowed young …


A Republic Not Kept: The Administrative State As A Constitutional Break, Noah Swanson Jan 2025

A Republic Not Kept: The Administrative State As A Constitutional Break, Noah Swanson

CMC Senior Theses

Conservatives often talk about the American people being governed by “unaccountable bureaucrats” who go against fundamental values of democracy and the Founding Fathers. While a common narrative, little evidence is given to reinforce these strong claims. This thesis works to investigate the accountability of the administrative state and its relationship to the philosophy of the Founding Fathers. Accountability is defined as administrative actions (regulations, notices, etc.) being in line with the original intent of the Congress that passed the action’s empowering statute. If the administrative state goes beyond the mere execution of these statutes and thereby the intent of the …


Fractured Simulacra: How Media Echo Chambers Shape Divergent Realities In Public Opinion, Nolan D. Windham Jan 2025

Fractured Simulacra: How Media Echo Chambers Shape Divergent Realities In Public Opinion, Nolan D. Windham

CMC Senior Theses

This thesis empirically investigates the relationship between exposure to time-varying partisan news content and individual policy attitudes. Combining individual-level Cooperative Election Study data (2020–2023, N≈68,000 for seven policy outcomes) with daily Fox News and MSNBC transcripts, I analyze how fluctuations in media narratives associate with public opinion. Leveraging large language models, I classify all relevant news segments by topic and ideological stance (liberal/conservative), generating daily time series of content volume and slant for each channel and policy issue. These series construct respondent-specific exposure measures based on self-reported viewership and 7-day rolling aggregates of media content preceding the survey interview date. …


Assessing Indonesia’S Potential Comparative Advantage In Downstream Petrochemical Industry Development: A Cost And Profitability Analysis, Daniel P. Yim Mr Jan 2025

Assessing Indonesia’S Potential Comparative Advantage In Downstream Petrochemical Industry Development: A Cost And Profitability Analysis, Daniel P. Yim Mr

CMC Senior Theses

As the Indonesian economy and population grow, domestic consumption of petrochemicals for the manufacture of downstream products, such as the plastics found in everyday life, has been increasing. However, despite robust demand for downstream chemicals such as polyethylene terephthalate (PET), polypropylene (PP), and polyethylene (PE), Indonesia consistently operates as a net importer of many upstream and downstream chemicals. It remains dependent on the Middle East, as well as on China, South Korea, Japan, Thailand, Singapore, and other countries. Although Indonesia utilizes more modern and recently built plants compared to its trading partners, the facilities are smaller in scale. Even for …


Intergenerational Influences On Mental Health Help-Seeking: The Role Of Parental Attitudes On Asian American College Students, Janet Cen Jan 2025

Intergenerational Influences On Mental Health Help-Seeking: The Role Of Parental Attitudes On Asian American College Students, Janet Cen

CMC Senior Theses

Asian American college students experience disproportionately high psychological distress yet underutilize mental health services. This study examined how demographic factors (gender, acculturation), psychological symptoms, personal stigma, and perceived parental attitudes predict help-seeking attitudes among 69 Asian American undergraduate students. Hierarchical regression analysis revealed that greater acculturation and more positive perceived parental attitudes were associated with more favorable help-seeking attitudes, while higher personal stigma predicted less favorable attitudes. Although psychological distress initially negatively predicted help-seeking attitudes, its effect became nonsignificant after accounting for personal stigma and perceived parental attitudes. Personal stigma and perceived parental attitudes remained robust predictors even after controlling …


Limitations Of The High-Resolution Rapid Refresh Gust Algorithm, Alex M. Glasser Jan 2025

Limitations Of The High-Resolution Rapid Refresh Gust Algorithm, Alex M. Glasser

Electronic Theses & Dissertations (2024 - present)

ABSTRACT:

Accurate wind and gust forecasts are crucial in operational meteorology, yet there is a distinct gap in the literature regarding the verification of operational gust forecasts. In the present work, we assess the performance of the High-Resolution Rapid Refresh's (HRRR) gust potential, verifying it against the Automated Surface Observing System's (ASOS) observed gusts across the Continental United States (CONUS). The HRRR gust's diurnal cycle reveals a significant underprediction of the gust during daylight hours and a slight overprediction of the gust during hours of darkness. The daytime underprediction undermines the assumption that forecasts represent a potential that tends to …


Isegoria In Crisis: Hong Kong's Innovation System And Articulating The Right To Be Heard Using Deliberative Democratic Theory, Bhanu Cheepurupalli Jan 2025

Isegoria In Crisis: Hong Kong's Innovation System And Articulating The Right To Be Heard Using Deliberative Democratic Theory, Bhanu Cheepurupalli

CMC Senior Theses

I argue that Hong Kong maintains democratic deliberation through its innovation policy apparatus despite lacking traditional democratic processes. Using deliberative democratic theory and the concept of isegoria (speech of equals before equals), I demonstrate how Hong Kong's innovation governance sustains meaningful consensus outside conventional democratic frameworks.

My analysis shows that while Hong Kong lacks free elections, democratic deliberation persists through alternative channels within science and technology governance. Innovation policy functions as a vehicle for justice-advancing deliberation despite institutional constraints, as deliberative bodies operate within limited time, authority, and resources.

I trace how Hong Kong's innovation policy apparatus developed through the …


Home: Ever A Work In Progress, Cayman Chen Jan 2025

Home: Ever A Work In Progress, Cayman Chen

CMC Senior Theses

Home: Work in Progress (2025), examines the concept of ‘home’ through a diasporic and transcultural lens to explore how personal and collective experiences of migration shape identity. Using the clothing of my loved ones, I constructed a wearable textile sculpture—creating a physical object that gathers the pieces of my home into one place. Through video performance, I embodied my sculpture as a living, breathing space that is alive with my own memories and experiences.


The Inextricable Link Between Gendered Security And State Stability: Strategic Costs Of U.S. Humanitarian Retrenchment, Kirby Eh Kimball Jan 2025

The Inextricable Link Between Gendered Security And State Stability: Strategic Costs Of U.S. Humanitarian Retrenchment, Kirby Eh Kimball

CMC Senior Theses

This thesis examines the strategic consequences of the 2025 U.S. foreign aid freeze on gendered security in conflict-affected states, focusing on Sudan, Syria, and Ukraine. It argues that gendered security—the protection, empowerment, and rights of women and girls—is not a peripheral humanitarian concern but a foundational determinant of state stability, development, and democratic resilience. Through a qualitative comparative case study methodology, the research synthesizes empirical literature, United Nations reports, human rights documentation, and cross-national statistical analyses to demonstrate how the collapse of gender-focused humanitarian programs following the aid freeze will critically exacerbate conflict-related sexual violence (CRSV), weaken state institutions, and …


From A Child's Perspective: A Qualitative Study Of Elementary School Student Engagement, Deanna J. Springstead-Gonzalez Jan 2025

From A Child's Perspective: A Qualitative Study Of Elementary School Student Engagement, Deanna J. Springstead-Gonzalez

Electronic Theses & Dissertations (2024 - present)

Abstract

Background and Purpose. This study sought to investigate child engagement from the children's perspective, aiming to understand better what they perceive as factors that facilitate or constrain their academic engagement in classrooms. By centering children's voices, this research challenges traditional views of students as passive recipients of education, instead recognizing them as active participants with valuable insights into their learning experiences. This work builds on the frameworks proposed by Shirley and Hargreaves (2021) and Lawson and Lawson (2013) that utilize socio-ecological theory to better understand those factors impacting children’s learning experiences.

Method. The study was conducted at an elementary …


Large Landlords, Code Violations, And Eviction Filing: Evidence From Albany, Ny, Andy Kaier Jan 2025

Large Landlords, Code Violations, And Eviction Filing: Evidence From Albany, Ny, Andy Kaier

Electronic Theses & Dissertations (2024 - present)

Eviction is a major contributor to cycles of urban poverty, and a growing body of research has documented eviction’s harmful effects. This study finds that landlord size and the number of code violations associated with the landlord’s portfolio both predict higher numbers of eviction filings. Using eviction filing data and newly available code violation data from Albany, NY in 2023 and 2024, this study examines landlord characteristics and their association with eviction filing. This study also examines public housing, finding that the Albany Housing Authority is the largest eviction filer in Albany in the study period. These findings are concerning …


Embracing The Unmanageable: The Critique Of The Everyday And The Postwar Condition In Wallace Stevens’ And Robert Duncan’S Works Circa 1950, Kazuma Morita Jan 2025

Embracing The Unmanageable: The Critique Of The Everyday And The Postwar Condition In Wallace Stevens’ And Robert Duncan’S Works Circa 1950, Kazuma Morita

Electronic Theses & Dissertations (2024 - present)

My thesis is designed as an investigation of the ethical and political implications of the everyday in postwar American poetry. While recent scholarship of everyday life studies has clarified the centrality of the everyday or the ordinary to modernism and postwar literature, it does not elaborate enough on the impact of the political condition on literary expressions of everyday life in post-1945 period. Given U.S. military’s infiltration into everyday life of people living inside and outside the country after World War II, it is an important task to spotlight the way American postwar poets tackled U.S. war culture through their …


The Right Way To Go Wrong: A Reflection, Peter A. Graham Jan 2025

The Right Way To Go Wrong: A Reflection, Peter A. Graham

CMC Senior Theses

This thesis documents my personal experience acting in Pomona College’s Fall 2024 production of The Play That Goes Wrong. I begin with an artist statement – a poem explaining the reasons why I act. The paper then moves into a general overview of the project, including my past training and future goals. The next section, which is the bulk of the material, contains chronological evidence of the production from start to finish and focuses on my attempt to find precise physicality. I finish with thoughts about the result as well as general reflections on how the process has shaped …


Elucidating The Effects Of Environmental And Physiological Conditions On Stem Cell Regulation In Vivo, Nimmy John Jan 2025

Elucidating The Effects Of Environmental And Physiological Conditions On Stem Cell Regulation In Vivo, Nimmy John

Electronic Theses & Dissertations (2024 - present)

The Notch signaling pathway is a highly conserved intercellular signaling pathway that any dysregulation can lead to a variety of human diseases. These diseases are further exacerbated by various environmental, pathological and genetic conditions. Previous studies have shown that these conditions have been known to affect the Notch transcriptional response. However, the molecular mechanisms by which such conditions influence Notch signaling remained largely unknown. Moreover, most Notch studies have relied on in vitro systems and indirect reporters, which can miss the dynamic and contextual nature of Notch signaling. Here, we systematically analyzed the effects of these conditions with single molecule …


Postcolonial Notions Of Criminality In Jane Eyre And Wide Sargasso Sea, Hannah M. Karim Jan 2025

Postcolonial Notions Of Criminality In Jane Eyre And Wide Sargasso Sea, Hannah M. Karim

Electronic Theses & Dissertations (2024 - present)

This thesis will use Charlotte Brontë's Jane Eyre and Jean Rhys’s Wide Sargasso Sea to gain a greater understanding of the postcolonial notions of criminality that are sustained and reproduced through racialized purity rhetoric and hierarchy. I argue that the restriction of the definition of the human, within scientific, religious, and legal realms, functioned towards the colonial end of sustaining racial hierarchy. In terms of its means of functioning, I argue that its need to function discretely is a direct response to the abolishment of slavery and with it, the shifting social demand for an appearance of reason, moral righteousness, …


Understanding Spatiotemporal Heterogeneity, Sources, And Health Risks Of Outdoor And Indoor Particles And Volatile Organic Compounds In Residential Neighborhoods, Sanchita Paul Jan 2025

Understanding Spatiotemporal Heterogeneity, Sources, And Health Risks Of Outdoor And Indoor Particles And Volatile Organic Compounds In Residential Neighborhoods, Sanchita Paul

Electronic Theses & Dissertations (2024 - present)

In the United States, community-level air quality observation networks often fall short in characterizing the wide array of air pollutants that influence human exposure from regional to neighborhood scales. While ambient air quality is routinely monitored in major urban centers, indoor air quality particularly within residential neighborhoods remains understudied, despite the fact that people spend the majority of their time indoors. This study presents a comprehensive assessment of outdoor and indoor air quality in the New York State (NYS) Capital Region and Hudson Valley communities of New York State, with a focus on fine particulate matter (PM2.5), volatile …


Differences In Mental Health Outcomes In Immigrant Vs. U.S.-Born Populations In Urban Vs. Rural Areas In The United States, Zoë Gentles Jan 2025

Differences In Mental Health Outcomes In Immigrant Vs. U.S.-Born Populations In Urban Vs. Rural Areas In The United States, Zoë Gentles

Electronic Theses & Dissertations (2024 - present)

Background

The immigration process to the United States creates distinct mental stressors. These stressors are influenced by socioeconomic factors including income, education level and insurance status. In rural America, these factors are intensified due to a poor healthcare infrastructure that is limited. This study examines the relationship between urban-rural residence and mental health outcomes among immigrants vs. native-born residents in the United States.

Methods

Data from the National Health Interview Survey (NHIS) from 2019 and 2022 were used to examine the relationship. The exposure of interest was place of birth, and the outcome of interest was the presence of clinically …


Student And Teacher Perceptions Of Student Capabilities And Their Relationships To Learning Experiences In A High-Poverty Rural School, Amanda J. Zullo Jan 2025

Student And Teacher Perceptions Of Student Capabilities And Their Relationships To Learning Experiences In A High-Poverty Rural School, Amanda J. Zullo

Electronic Theses & Dissertations (2024 - present)

Background and Purpose. This study was designed to identify, delineate, and explain the significant factors contributing to high school students’ relatively better graduation outcomes in a high-poverty rural region in New York State. Emphasis was placed on identifying key characteristics of the relationships between students’ and teachers’ perceptions of student capabilities and the qualities of student learning experiences. This study drew upon secondary data from a two-phase study of positive outlier schools identified as having significantly better graduation rates than other schools with similar demographic profiles. Informed by Mindset Theory and Authentic Learning Theory, the study examined how personal, social, …


Musical Motivation: Investigating Musical Contingent Self-Worth And Its Interactions With Music Training And Perceived Musical Ability, Douglas Allan Kowalewski Jan 2025

Musical Motivation: Investigating Musical Contingent Self-Worth And Its Interactions With Music Training And Perceived Musical Ability, Douglas Allan Kowalewski

Electronic Theses & Dissertations (2024 - present)

This program of research centers on a novel measure of how much value one places on having and displaying their musical ability – musical contingent self-worth – and how that construct interacts with existing measures of music training and perceived musical ability to predict performance on both musical and general cognitive tasks. Two studies (Experiments 1 and 2) provide evidence for the validity and reliability of an MCSW scale and additionally show that it uniquely predicts both reactions to, and performance on, a musical skills task (Experiment 1). These initial studies also show that MCSW interacts with music training to …


Tapping A Hidden Resource In Classrooms: Peer Interactions And Their Role In Language, Literacy, And Disciplinary Literacy Practices Among Adolescent English And Non-English Learners, Jina Byeon Jan 2025

Tapping A Hidden Resource In Classrooms: Peer Interactions And Their Role In Language, Literacy, And Disciplinary Literacy Practices Among Adolescent English And Non-English Learners, Jina Byeon

Electronic Theses & Dissertations (2024 - present)

This qualitative case study examines how peer interactions among six seventh-grade English Learners (ELs) and non-ELs serve as both a context for and a method of developing adolescents' literacy and disciplinary literacy practices. Data sources include two semi-structured interviews with each student and their four classroom teachers, student and teacher ethnographic interviews, 300 hours of classroom observations (in English Language Arts, Social Studies, Math and Science, English as a New Language Tutorial), and student-generated artifacts (e.g., worksheets).

Through the application of iterative and thematic data analysis, three key themes were identified: 1) adolescents' interactions with their peers fostered a supportive …


Diversity Within Species: Mechanisms, Evolution And Implications In Bacterial Disease, Kathryn R. Piper Jan 2025

Diversity Within Species: Mechanisms, Evolution And Implications In Bacterial Disease, Kathryn R. Piper

Electronic Theses & Dissertations (2024 - present)

The Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli are ubiquitous commensal and opportunistic pathogens. In humans, S. aureus is commonly found on the skin and mucus membranes, and is known to cause infections in the skin, bloodstream and brain. E. coli is a normal part of the gut microbiota in humans and can cause intestinal and extraintestinal infections alike. S. aureus and E. coli pose global threats to public health, due to the high morbidity and mortality of invasive strains. The wide range of infections they cause in humans and other animals are exacerbated by the presence …


Evaluation Of High-Risk Factors For Maternal Mortality At Specialist Hospital, Yola, Adamawa State, Nigeria, U. B. Danfulani, E. D. Dzarma, A Uduak Jan 2025

Evaluation Of High-Risk Factors For Maternal Mortality At Specialist Hospital, Yola, Adamawa State, Nigeria, U. B. Danfulani, E. D. Dzarma, A Uduak

All Rsif Scholars' Publications

Maternal health disparities in Nigeria are pronounced, with higher maternal mortality rates (42 per 1,000 live births) and poor outcomes driven by education, healthcare access, and cultural factors like polygamy. Hence, the objective of this paper was to evaluate the effect of High-Risk Factors for Maternal Mortality at Specialist Hospital, Yola, Adamawa State, Nigeria using appropriate standard procedures with Application of Multi-Criteria Decision Modeling (MCDM) Using the Analytical Hierarchy Process (AHP). Data obtained reveals that Infant mortality is high, with under-five mortality at 120 per 1,000 and neonatal mortality at 2 per 1,000 live births. Healthcare system challenges include limited …


Aviation Cybersecurity And Third-Party Software Service Providers: Do Companies Like Crowdstrike Get A Free Pass To Create Cyber Vulnerabilities?, Claire Konerza Jan 2025

Aviation Cybersecurity And Third-Party Software Service Providers: Do Companies Like Crowdstrike Get A Free Pass To Create Cyber Vulnerabilities?, Claire Konerza

Journal of Air Law and Commerce

Commercial aviation has steadily become the busiest and most efficient means of travel across the world. In order to keep up with the increasing demands of its customers, the industry has undergone numerous digital and technological transformations in recent years. Collision avoidance systems have allowed for more planes in the skies, online ticket reservations have made booking a flight as simple as a few clicks, and in-flight wi-fi allows passengers to engage in both work and leisure at 30,000 feet. Overall, these innovations have increased safety, capacity, and convenience for both airlines and their customers. However, these transformations have also …


Numerus Clausus No More: A Fundamental Shift In Delaware Corporate Law, Usha Rodrigues Jan 2025

Numerus Clausus No More: A Fundamental Shift In Delaware Corporate Law, Usha Rodrigues

Scholarly Works

This Essay applies Thomas Merrill and Henry Smith’s theory of numerus clausus—the idea that a limited menu of legal forms reduces transaction costs—to the world of business entities. Historically, investors had a straightforward choice: the decentralized general partnership or the centralized corporation, each with predictable governance and liability rules. Even innovations like the LLC, benefit corporation, and L3C merely expanded the list of standard options, preserving a clear, finite set of organizational forms.

But recent changes in Delaware corporate law have shattered this standardization norm. The addition of Section 122(18) to the Delaware General Corporation Law, combined with increasing reliance …


New Genetic Tools To Define The Pathophysiology Of Inborn Errors Of Cobalamin Metabolism Impacting Mammalian Development, Tiffany Chern, Xuefei Tong, William G Bauer, David J Quispe-Parra, Xia Gao, Kamryn N Gerner-Mauro, Ross A Poché Jan 2025

New Genetic Tools To Define The Pathophysiology Of Inborn Errors Of Cobalamin Metabolism Impacting Mammalian Development, Tiffany Chern, Xuefei Tong, William G Bauer, David J Quispe-Parra, Xia Gao, Kamryn N Gerner-Mauro, Ross A Poché

Children’s Nutrition Research Center Staff Publications

The congenital, autosomal recessive disorder combined methylmalonic acidemia and homocystinuria - cblC type, is the most common inborn error of cobalamin (vitamin B12) metabolism. In its early onset form, cblC profoundly impacts fetal development of the central nervous system, hematopoietic system, and other tissues. Previously, mutations in the MMACHC gene, which encodes a protein required for the intracellular trafficking and enzymatic processing of free cobalamin into active coenzyme forms, were found to cause cblC. These coenzymes are required in two metabolic pathways which produce either succinyl-CoA in the mitochondria or methionine in the cytosol. However, due to a lack of …