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The Death Of The American Dream: How Inequality, Injustice, And Individualism Shatters Its Promise As A Unifying Force, Shaira Busnawi Jan 2025

The Death Of The American Dream: How Inequality, Injustice, And Individualism Shatters Its Promise As A Unifying Force, Shaira Busnawi

CMC Senior Theses

The American Dream has long been celebrated as a unifying ideal, promising opportunity, upward mobility, and success to all who work diligently. However, this thesis argues that the Dream no longer fulfills its role as a cohesive organizational mechanism for American society. Instead, it perpetuates inequality, fosters competition over cooperation, and fails to address systemic barriers faced by marginalized communities. The analysis begins with the historical evolution of the American Dream and its transformation in the aftermath of the 2008 financial crisis, exposing structural flaws that have eroded public trust in its attainability. Case studies on rural Appalachian communities and …


The Public Face Of Private Credit: Performance Dynamics In Business Development Companies, Russell Kuan Jan 2025

The Public Face Of Private Credit: Performance Dynamics In Business Development Companies, Russell Kuan

CMC Senior Theses

This study examines the performance dynamics of public Business Development Companies (BDCs) – a unique and growing component of the private credit market that bridges public and private financing. Publicly traded BDCs provide critical capital to underserved middle-market firms, while giving investors access to private credit opportunities. Using a hand-pulled dataset derived from 10-K filings and supplemental sources, this research identifies the key financial and operational factors driving BDC performance, with a focus on senior secured loan allocations, portfolio yield, and leverage strategies. The findings reveal that portfolio yield and senior secured loan allocations are significant predictors of total returns …


“Google Is Free:” The Harm In Deferring To Information Technology And The Reimplementation Of Interpersonal Connection As A Solution, Nicole Cepeda Jan 2025

“Google Is Free:” The Harm In Deferring To Information Technology And The Reimplementation Of Interpersonal Connection As A Solution, Nicole Cepeda

CMC Senior Theses

In this thesis, I confront the phenomenon that is information technology and the epistemological issues that it raises. I address how we should engage with the online resources allotted to us by media conglomerates, given both the variety of epistemic perspectives that they relay back to the user, from disenfranchised affinity to fake news, and the respective biases of the user. I propose that by reintroducing an interpersonal communicative framework, we are able to create a system that allows users to work deconstruct their biases and learn new information more effectively, all while users are able to flag information as …


A Guide To Creating Trans And Gender Variant Inclusive Film Sets: For Directors And Department Heads On Non-Union/Low Budget Film Sets, Perce Alvarez Jan 2025

A Guide To Creating Trans And Gender Variant Inclusive Film Sets: For Directors And Department Heads On Non-Union/Low Budget Film Sets, Perce Alvarez

CMC Senior Theses

The following thesis explores transgender and gender-variant inclusivity practices in film production. It conducts an overview of information on lgbtq+ and transgender populations, discrimination, and filmmaking practices. From there, a baseline of definitions for terms and worldviews adopted by transgender and gender-variant communities is established. Primarily, this thesis focuses on establishing reasoning for and presenting practical applications of transgender inclusivity that can be implemented throughout the film production process. It accomplishes this by focusing on specific parts of the production process and how the leaders of those subprocesses can put these inclusivity practices into action.


The Solar Power Of Pricing: Does Electricity Pricing Policy Drive Residential Solar Demand?, Talia De Beer Jan 2025

The Solar Power Of Pricing: Does Electricity Pricing Policy Drive Residential Solar Demand?, Talia De Beer

CMC Senior Theses

Solar energy has emerged as a pivotal renewable energy source, experiencing significant growth in the United States over the past two decades. As policymakers continue to develop and refine the best methods to incentivize solar adoption while reflecting true costs and potential equity concerns, this paper seeks to evaluate the impact of changes in solar pricing policies on residential solar installations. Employing a difference-in-differences regression model, this study examines the effects of policy changes on both the system capacity and number of installations of adoption in three Western states that have transitioned away from traditional Net Energy Metering (NEM) policies–Arizona, …


Infiltrated Markets: The Italian Mafia's Influence On Waste Management, Retail, And Economic Integrity For Illicit Gain, Giselle Adiyia Jan 2025

Infiltrated Markets: The Italian Mafia's Influence On Waste Management, Retail, And Economic Integrity For Illicit Gain, Giselle Adiyia

CMC Senior Theses

The Italian Mafia, encompassing groups like the Cosa Nostra, Camorra, and 'Ndrangheta, has historically exerted significant influence across Italy’s economy and governance through criminal and legitimate enterprises. This thesis investigates the Mafia’s infiltration into the waste management and retail sectors, employing a mix of economic data analysis and theoretical frameworks to uncover the mechanisms and extent of their impact. Using publicly available data from Bloomberg Terminal, the United Nations Office on Drugs and Crime (UNODC), and the Italian National Institute of Statistics (ISTAT), this study examines indicators such as corruption, extortion, money laundering, environmental crimes, and drug trafficking.

Simple regression …


Maximizing The Mlb Draft: How College Performance And Leverage Impact Player Signing Bonus And Team Payoff, Derek Seneker Jan 2025

Maximizing The Mlb Draft: How College Performance And Leverage Impact Player Signing Bonus And Team Payoff, Derek Seneker

CMC Senior Theses

This thesis examines the factors that enable NCAA Division I college position players to maximize their signing bonuses in the MLB draft. I focus on how performance metrics, player characteristics, and program-related attributes shape bonus outcomes relative to draft slot values. Using data from the top five rounds of MLB drafts from 2012 to 2022, this research provides insights into optimal valuation strategies for draft prospects. Additionally, it explores whether higher signing bonuses correlate with a player’s likelihood of eventually making their MLB debut, assessing the potential return on investment for MLB teams. By filling a gap in existing literature, …


Weighted War: A Team-Specific Approach To Optimizing Mlb Rosters, Paul Wendler Jan 2025

Weighted War: A Team-Specific Approach To Optimizing Mlb Rosters, Paul Wendler

CMC Senior Theses

This paper introduces a new baseball statistic, Weighted WAR (wWAR), designed to enhance Major League Baseball (MLB) roster optimization by incorporating team-specific factors into player valuation. Traditional WAR (Wins Above Replacement) offers a generalized measure of player performance relative to the league minimum salaried player. The study bridges the gap by developing wWAR, a customizable, team-specific framework for evaluating player impact. Taking player data, team data, and salary data from 2021-2023 the study proves the significance of wWAR’s impact relative to the traditional WAR statistic using case studies and regression analysis. The results demonstrate that wWAR outperforms traditional WAR in …


High ‘Steaks’: Does Lone Star Tick-Induced Red Meat Allergy Reduce Cardiovascular Disease-Related Hospitalizations?, Raj Parekh Jan 2025

High ‘Steaks’: Does Lone Star Tick-Induced Red Meat Allergy Reduce Cardiovascular Disease-Related Hospitalizations?, Raj Parekh

CMC Senior Theses

In this thesis, I investigate the relationships between Lone Star Tick-induced Alpha-Gal Syndrome (AGS), red meat consumption, and cardiovascular health outcomes within New York State's 62 counties from 2012 to 2021. The analysis examines whether AGS, which forces individuals to reduce red meat consumption, serves as a natural experiment in understanding dietary impacts on cardiovascular disease (CVD). Leveraging panel data, I utilize Fixed Effects (FE) and Two-Stage Least Squares (2SLS) regression frameworks to disentangle the relationships between red meat expenditure, meat prices, Lone Star Tick prevalence, and health outcomes such as CVD, stroke, coronary heart disease, and heart attack hospitalization …


Just As Advertised: The Perception And Effectiveness Of Artificial Intelligence In Digital Advertising, Brandon Isem Cáceres Jan 2025

Just As Advertised: The Perception And Effectiveness Of Artificial Intelligence In Digital Advertising, Brandon Isem Cáceres

CMC Senior Theses

What do you think when you hear “AI in advertising”? Does it spark intrigue, or does it feel like just another tech buzzword? In today’s fast-paced digital marketing landscape, connecting with consumers is a high-stakes challenge, and artificial intelligence is at the forefront of innovation. From automating campaigns to creating hyper-targeted content, AI promises efficiency and precision—but how do audiences perceive this shift? By analyzing key performance indicators (KPIs) like impressions, click-through rates, and cost-per-click in an an original A/B test, this thesis evaluates the perception and effectiveness of AI-driven advertising strategies. Combining historical insights, case studies, and an original …


The Rationality Of Cooperation In One-Shot Prisoner's Dilemmas: A Defense Of David Gauthier's Constrained Maximization, Carlos Hernandez Jan 2025

The Rationality Of Cooperation In One-Shot Prisoner's Dilemmas: A Defense Of David Gauthier's Constrained Maximization, Carlos Hernandez

CMC Senior Theses

For moral skeptics and self-interested individuals, it is difficult for them to recognize the need and benefit for cooperation. That is, there is an intrinsic conflict in claiming that constraining one’s self-interest when cooperating with others serves to promote an individual’s self-interest. Even so, David Gauthier provides constrained maximization as a rational choice theory that addresses this conflict and balances the concepts of rationality and morality. Constrained maximization demonstrates to the moral skeptics and self-interested individuals that cooperation is in their self-interest when using the situation of the Prisoner’s Dilemma. Yet, as Holly Smith highlights, constrained maximization does not provide …


Should Students Pull The Plug?: How Ai Redefines Creativity In The Classroom, Labiba Hassan Jan 2025

Should Students Pull The Plug?: How Ai Redefines Creativity In The Classroom, Labiba Hassan

CMC Senior Theses

This paper examines how artificial intelligence (AI) tools, specifically ChatGPT as a tutor for students (ChatGPTt), reshapes creativity in the classroom. Does AI undermine or enrich creativity by altering its relational and self-disclosive dimensions? Engaging with Lindsay Brainard’s critique that AI erodes creativity by disrupting human connection and self-expression, I argue for a redefinition of creativity as a dynamic process sustained by emotion, intention, novelty, risk, and spontaneity — conditions adaptable to AI-mediated contexts. The paper challenges the premise that creativity depends on interpersonal connection, showing that self-disclosure can emerge through meaningful engagement with external systems, such as ChatGPTt. By …


Approaching Freedom Of Speech: The Perils Of Exceptionalism, Insincerity, And Hatred, Noah Hendelman Jan 2025

Approaching Freedom Of Speech: The Perils Of Exceptionalism, Insincerity, And Hatred, Noah Hendelman

CMC Senior Theses

This thesis examines the philosophical underpinnings and practical implications of free speech theories in the context of contemporary challenges to maintaining a trustworthy and equitable speech environment. I begin by presenting and rejecting the theory of Free Speech Exceptionalism. I maintain that a principle is needed to underlie our approach to free speech, and the principle should be based on an independent value, rather than a retrospective analysis of speech law. I argue the principles behind a thinker-based approach are particularly appealing in light of their alignment with our considered convictions related to speech. The analysis extends to the contentious …


Altman Z-Score Relationship With Stock Price Performance After Layoff Announcements, Natalie Phillips Jan 2025

Altman Z-Score Relationship With Stock Price Performance After Layoff Announcements, Natalie Phillips

CMC Senior Theses

This paper examines the broader implications of such workforce reductions, historically prevalent in corporate environments since the advent of "new capitalism" in the late 20th century. Characterized by intense global competition, deregulation, and technological advancements, this era saw a surge in corporate downsizing as a means to enhance efficiency and competitiveness. Despite the strategic intentions, layoffs often signal underlying organizational challenges, prompting critical inquiry into their short- and long-term impacts on firm performance and investor sentiment. Central to this study is the exploration of whether a firm's Altman Z-Score, a metric predicting bankruptcy risk, influences stock price reactions following layoff …


The Black Spectacle And Oppressive Double Binds: What Rap On Trial Reveals About Race, Exploitation, And Criminalization In The Music Industry, Giovanni Pierre Jan 2025

The Black Spectacle And Oppressive Double Binds: What Rap On Trial Reveals About Race, Exploitation, And Criminalization In The Music Industry, Giovanni Pierre

CMC Senior Theses

In this paper, I investigate the paradox revealed by the Young Thug trial where certain portrayals of Blackness in rap music are simultaneously praised and punished by white institutions. I propose that the theatrics of the Young Thug trial and other instances of rap lyrics used in criminal trials are emblematic of what I call the Black Spectacle. The Black Spectacle is the role Blackness plays in American entertainment. It has three elements: (1) It entertains white audiences because of Black people’s perceived otherness, (2) it provides white people, particularly white men, with a vehicle through which they can …


China’S Economic Slowdown: How Does It Affect New Zealand’S Economy?, Haven Qin Jan 2025

China’S Economic Slowdown: How Does It Affect New Zealand’S Economy?, Haven Qin

CMC Senior Theses

This paper examines the impact of China’s economic slowdown on New Zealand’s economy, focusing on sector-specific linkages across real estate, the stock market, exports, and import prices. As a small open economy, New Zealand’s deep integration with global markets makes it particularly vulnerable to external shocks from its largest trading partner. Employing OLS regression models and monthly economic data, this study reveals the nuanced pathways through which China’s economic conditions influence New Zealand. Key findings include the sensitivity of New Zealand’s housing market to Chinese property investments and Chinese stock market performance, the influence of Chinese financial market performance on …


Labor Versus Capital: Impacts Of Employment Lawsuits On Capital Expenditures, Victoria Williams Jan 2025

Labor Versus Capital: Impacts Of Employment Lawsuits On Capital Expenditures, Victoria Williams

CMC Senior Theses

This thesis explores the relationship between employment-related litigation and capital expenditures (CapEx) within firms, particularly focusing on the trade-off between labor and capital as automation becomes increasingly viable. It investigates whether legal challenges in the form of labor lawsuits prompt companies to increase investments in automation to mitigate future labor risks and costs related to employing human workers. The research includes analysis of the impact of litigation on CapEx across different time periods and industries. Results suggest a significant, though not unequivocally robust, positive correlation between litigation and CapEx increases. Notably, the impact of litigation on CapEx was more pronounced …


Pay-Performance Sensitivity: How Firm Performance Impacts Ceo Compensation, Yuefeng Ma Jan 2025

Pay-Performance Sensitivity: How Firm Performance Impacts Ceo Compensation, Yuefeng Ma

CMC Senior Theses

This study investigates the relationship between firm performance and CEO compensation, revisiting and extending the foundational framework established by Jensen and Murphy (1990). The sample comprises compensation data for the Chief Executive Officer (CEO) of all publicly traded companies on the Wharton Research Data Services (WRDS) Compustat – ExecuComp dataset from 1994 to 2023. Using Ordinary Least Squares (OLS) regression models, the analysis evaluates the sensitivity of CEO pay to changes in shareholder wealth and other performance metrics, while accounting for structural and temporal shifts driven by corporate governance, macroeconomic environment, and legislation. The findings reveal that changes in shareholder …


Evaluating The Dual-Faceted Growth Strategies In The Healthcare Sector: A Comparative Analysis Of Organic Innovation And Inorganic Expansion, Isabel Carter Jan 2025

Evaluating The Dual-Faceted Growth Strategies In The Healthcare Sector: A Comparative Analysis Of Organic Innovation And Inorganic Expansion, Isabel Carter

CMC Senior Theses

In order to stay competitive in an expansionary industry like healthcare, companies must consistently meet market demands for growth. This paper builds an empirical model to identify which growth strategies are most highly rewarded by the public markets. The model consists of a data set of 70 healthcare companies, across various healthcare verticals, to measure market returns from 2010 to 2023. The number of completed acquisitions is used as a proxy to identify each company’s propensity towards a growth strategy. Factors from the Fama-French Model and dummy variables used to signal growth strategy expertise, indicate that firms who invest more …


The Impact Of Ceo Changes On The Recovery Of It Firms That Have Experienced Substantial Reductions In Value (2010-2024), Amanda Dee Jan 2025

The Impact Of Ceo Changes On The Recovery Of It Firms That Have Experienced Substantial Reductions In Value (2010-2024), Amanda Dee

CMC Senior Theses

The informational technology (IT) industry is one of the most dynamic industries, and the CEO plays a crucial role in steering innovation. The dependence on innovation is associated with dynamics that bring heightened volatility and force firms and their CEOs to confront significant challenges, particularly when navigating periods of substantial reductions in value. I define distress as three-year cumulative returns that are negative and underperform the market by more than 30%. Firms that meet this criteria during 2010-2017 are analyzed using regression models to assess how CEO change influences the likelihood of their recovery, defined as achieving nine-year cumulative returns—including …


We Are All Mestiz(Ç)Os: An Exploration And Deconstruction Of The Myth Of Mestizaje/Mestiçagem In Mexico And Brazil, Michelle Garcia Jan 2025

We Are All Mestiz(Ç)Os: An Exploration And Deconstruction Of The Myth Of Mestizaje/Mestiçagem In Mexico And Brazil, Michelle Garcia

CMC Senior Theses

Different from the United States, racial-mixing was permissible in Latin America throughout its history. Furthermore, race-mixing has been cemented into the national identities of LatAm states through Mestizaje, thus painting these states as racial democracies. This thesis examines the construction and maintenance of Mestizaje as a myth and sign for racial democracies as well as the racial disconnect created within those in “Mestizo” nations. This thesis contributes to existing literature by utilizing Mexico and Brazil due to their different socio-historical contexts. They will serve as case studies to evaluate the mechanisms that allow this myth to persevere. First, I will …


Effect Of Paxlovid On Neurodevelopmental Disorder Diagnosis Outcomes In Offspring Of Mothers Infected With Sars-Cov-2 During Pregnancy, Simone Rogers Jan 2025

Effect Of Paxlovid On Neurodevelopmental Disorder Diagnosis Outcomes In Offspring Of Mothers Infected With Sars-Cov-2 During Pregnancy, Simone Rogers

CMC Senior Theses

The onset of the 2020 COVID-19 pandemic brought concern over the effects that this virus would have on pregnancy and fetal outcomes, specifically neurodevelopmental outcomes. Maternal immune activation (MIA), caused by infection during pregnancy, is known to result in neurodevelopmental disorder (NDD) diagnosis in offspring, typically autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). This effect has already been observed in mothers who were infected with COVID-19 during pregnancy. However, in 2023, Paxlovid, the COVID-19 antiviral drug, became available to patients experiencing symptoms of the virus, including pregnant women. Consequently, this study seeks to determine whether the risk of …


Addressing Chronic Stress: Activating The Healing Responses, Lily Walther Jan 2025

Addressing Chronic Stress: Activating The Healing Responses, Lily Walther

CMC Senior Theses

This paper seeks to explore the negative effects of chronic stress on the body, emphasize the tissue, cellular, and genetic healing responses that exist to combat these effects, and illustrate the behavioral and physiological interventions that can activate these responses. The concepts of stress and chronic stress have been explained through a progression of models that have been updated over the decades. This includes early theories such as The General Adaptation Syndrome and the Homeostatic Model, as well as more recent depictions such as the Reactive Scope Model. The healing responses are explored on a variety of levels to illustrate …


A Spectroscopy Study Of The Brain: Exploring Sex Differences In Healthy Older Adults, Angela Gushue Jan 2025

A Spectroscopy Study Of The Brain: Exploring Sex Differences In Healthy Older Adults, Angela Gushue

CMC Senior Theses

Cognitive decline and aging-related disorders, such as Alzheimer’s, disproportionately affect patients based on sex, but the mechanisms underlying these skewed effects are unknown. This proton magnetic resonance spectroscopy (H-MRS) study seeks to understand if sex disparities in aging exist in neurometabolite concentrations of older adult brains. Sixty-seven participants, ranging from 60 to 85 years of age, underwent the Montreal Cognitive Assessment (MoCA) and H-MRS of the brain. Concentrations of myo-inositol, total creatine, total NAA, and total choline were calculated in the dorsal posterior cingulate cortex, left hippocampal cortex, left medial temporal gyrus, left primary sensorimotor cortex, and right dorsolateral prefrontal …


From Fields To Fast Foods: Food Culture, Identity, And Health In Puerto Rico Under The U.S. Empire, Ivanna Morales Mercado Jan 2025

From Fields To Fast Foods: Food Culture, Identity, And Health In Puerto Rico Under The U.S. Empire, Ivanna Morales Mercado

CMC Senior Theses

Operation Bootstrap, launched in 1947, fundamentally altered Puerto Rico’s economy, just as much as its food culture. Prioritizing manufacturing over agriculture led to the collapse of the island’s farming sector, increasing reliance on food imports and leading to a rise in diet-related diseases such as obesity, type 2 diabetes, and cardiovascular issues. This thesis examines the legacies of Operation Bootstrap on Puerto Rico’s food system, health outcomes, and cultural identity by emphasizing the need to value intergenerational knowledge. The oral history research in this study highlights the importance of intergenerational knowledge in reclaiming sustainable agricultural practices and healthy, culturally significant …


Investigating The Impact Of Phthalate Exposures From Personal Care Products On Uterine Fibroid Incidence And Prevalence In Us-Born Black Women, Ella Brissett Jan 2025

Investigating The Impact Of Phthalate Exposures From Personal Care Products On Uterine Fibroid Incidence And Prevalence In Us-Born Black Women, Ella Brissett

CMC Senior Theses

Uterine fibroids are benign tumors composed of smooth muscle cells and connective tissue that develop within or on the walls of the uterus. Despite being non-cancerous, they can severely affect quality of life by causing heavy bleeding, chronic pain, and reproductive complications. Fibroids are typically found in women of reproductive age, but they disproportionately affect Black women, who experience higher incidence and severity. The underlying causes of this disparity is poorly understood; however, an emerging body of research is highlighting the role of phthalates, endocrine-disrupting chemicals found in many personal care products, in exacerbating fibroid development. Through a critical analysis …


Comparative Analysis Of Lipid Accumulation And Antioxidant Responses In Masld And Control Ipsc-Heps, Anna Werts Jan 2025

Comparative Analysis Of Lipid Accumulation And Antioxidant Responses In Masld And Control Ipsc-Heps, Anna Werts

CMC Senior Theses

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition characterized by lipid accumulation and associated inflammation, driven by genetic, environmental, and metabolic factors. Much is still unknown about the mechanisms of the disease, and research on this is important for advancing effective treatments. This study investigated lipid accumulation and oxidative stress responses to varying concentrations of oleic acid (OA) and palmitic acid (PA) in induced pluripotent stem cell-derived hepatocytes (iPSC-Heps) from MASLD and healthy donors. BODIPY staining revealed that MASLD iPSC-Heps exhibit significantly higher lipid accumulation than controls, especially under prolonged OA and PA exposure. Additionally, PLIN2 expression …


Regulation Of Neuronal Autophagy By Amyotrophic Lateral Sclerosis (Als) - Associated Kinase Tbk1: Evaluating The Role Of Ncoa7, Vikram Chatterjee Jan 2025

Regulation Of Neuronal Autophagy By Amyotrophic Lateral Sclerosis (Als) - Associated Kinase Tbk1: Evaluating The Role Of Ncoa7, Vikram Chatterjee

CMC Senior Theses

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease characterized by motor neuron loss and the pathological accumulation of misfolded proteins. Autophagy, a lysosome-mediated clearance mechanism, plays a vital role in maintaining cellular homeostasis by removing damaged organelles and protein aggregates. Impairments in autophagy have been increasingly linked to ALS, underscoring its importance in neuronal health. TANK-binding kinase 1 (TBK1) is a key regulator of selective autophagy, facilitating the recognition and sequestration of specific cargo through phosphorylation of autophagy receptors. Notably, mutations in the TBK1 gene have been identified in ALS patients, directly implicating TBK1 dysfunction in disease pathogenesis. Through …


Ubiquitin, Cavitand, And Nmr: 15n-1h Hsqc Analysis Of Cavitand Binding Domains On Ubiquitin, Grant Stucky Jan 2025

Ubiquitin, Cavitand, And Nmr: 15n-1h Hsqc Analysis Of Cavitand Binding Domains On Ubiquitin, Grant Stucky

CMC Senior Theses

Ubiquitin and its derivatives through side chain modification are present in many of the degradation pathways for proteins found in neurodegenerative diseases. A non-toxic method for determining the amount of these proteins could have biosensing applications, but the binding domains of such proteins are not well characterized. 15N-1H HSQC analysis of ubiquitin’s interactions with different concentrations of a small negatively charged host molecule called cavitand provides insight into the binding interactions with side chains on the protein such as lysine and arginine. This is done comparing the HSQC spectra of different concentrations of cavitand and ubiquitin to …


The Garden Of Pdyn: The Impact Of Pdyn Gene Deletion On Ethanol Self-Administration And Reinforcement In Female Mice, Catherine Ruan Jan 2025

The Garden Of Pdyn: The Impact Of Pdyn Gene Deletion On Ethanol Self-Administration And Reinforcement In Female Mice, Catherine Ruan

CMC Senior Theses

Debilitating over-consumption of alcohol, often culminating into a prevalent psychiatric disorder known as alcohol use disorder (AUD), stands as one of the United States’ most expensive societal battles to face (Harwood et al., 1998). Consequently, the public’s desire and scientists’ motivation to develop novel pharmacological solutions to treat it is high. Recent and ongoing research presents new insights into the role of the dynorphin/kappa opioid receptor (DYN/KOR) system as an inhibitor of dopamine release and a regulator of the negative affective states that come with alcohol withdrawal (Karkhanis et al., 2017). However, this growing body of literature is predominantly conducted …