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Articles 2521 - 2550 of 5150758
Full-Text Articles in Entire DC Network
The Shorthorn: September 12, 1986
The Shorthorn: September 12, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 11, 1986
The Shorthorn: September 11, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 10, 1986
The Shorthorn: September 10, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 9, 1986
The Shorthorn: September 9, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 5, 1986
The Shorthorn: September 5, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 4, 1986
The Shorthorn: September 4, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 3, 1986
The Shorthorn: September 3, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Anxious Patient: How Breathing, Presence, And Calming Cues Transform What Happens In The Dental Chair, Kelly Davis Pt, Dpt, Faaompt, Mt
The Anxious Patient: How Breathing, Presence, And Calming Cues Transform What Happens In The Dental Chair, Kelly Davis Pt, Dpt, Faaompt, Mt
New Orleans Dental Association News
In part two of her three-part series for NODA News, Dr. Kelly Davis, PT, DPT, FAAOMPT, MTC, explains why a dentist's own regulation is one of the most powerful tools in the operatory. Dental anxiety triggers a genuine sympathetic nervous system response — elevated heart rate, muscle guarding in the jaw and neck, and a body primed for threat — that makes procedures harder for patient and clinician. Dr. Davis introduces co-regulation, the neuroscience-backed principle that a calm, grounded provider can help settle an anxious patient's nervous system through presence alone. She offers concrete, simple techniques dentists can use before, …
The Increasing Degree Of Salivary Diagnostics In Healthcare, Kristi M. Soileau, Joseph Zimmermann, Preston Tran
The Increasing Degree Of Salivary Diagnostics In Healthcare, Kristi M. Soileau, Joseph Zimmermann, Preston Tran
New Orleans Dental Association News
Saliva is being researched as a potential significant player in disease diagnostics. The financial implications could likely become much more noteworthy, as dentists and physicians recognize. The many benefits of salivary testing over the more traditional methods of blood and urine sampling, while there remains much research to be performed to fully elucidate both the benefits and limitations of salivary diagnostics, this field promises to shine a brighter light on making healthcare testing more affordable, practical, and pleasant overall.
Noda News September 2026
New Orleans Dental Association News
New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.
Identification Of Current Ai Usage In The Fields Of Exercise-Related Professions And The Requirement Of Ai Experience As A Hiring Criterion: A Preliminary Study, Michelle Stehman, Matthew Hankinson
Identification Of Current Ai Usage In The Fields Of Exercise-Related Professions And The Requirement Of Ai Experience As A Hiring Criterion: A Preliminary Study, Michelle Stehman, Matthew Hankinson
Educational Practices in Kinesiology
Artificial intelligence (AI) is increasing within exercise-related professions, raising the question of whether college curricula for these professions should include AI education. This study aimed to evaluate current AI usage and to discover the priority of AI skills for hiring managers among exercise-related professionals. Section one of the questionnaire included questions about current use of AI within exercise-related professions (N = 65), and section two was specific to hiring managers and their position on AI skills as a hiring requirement (n = 32 completed this section). The main outcome of this study was that 32% of exercise-related professionals …
Depoarch: Physics-To-Architecture Modeling And Mitigation Of Thin-Film Deposition Non-Idealities In Advanced Multicore Processors, Gopi K. Tummala
Depoarch: Physics-To-Architecture Modeling And Mitigation Of Thin-Film Deposition Non-Idealities In Advanced Multicore Processors, Gopi K. Tummala
Defensive Publications Series
As semiconductor fabrication scales toward atomic dimensions in sub-3 nm gate-all-around (GAAFET) and complementaryFET (CFET) architectures, physical non-idealities in thin-film deposition increasingly govern chip performance, energy efficiency, and long-term reliability. Traditional computer architecture research has long abstracted the underlying silicon fabric as a set of deterministic, planar geometries characterized by nominal resistance-capacitance (RC) parasitics, treating process variation strictly through empirical statistical abstractions such as Random Dopant Fluctuations (RDF) and sub-wavelength Line Edge Roughness (LER). In reality, the physical mechanisms of Chemical Vapor Deposition (CVD) and Physical Vapor Deposition (PVD) impart severe, deterministic spatial gradients and microscopic structural flaws that break …
Mitigating Multi-Scale Variability In Datacenters: In-Situ Physical Sensing, Proactive Thermal-Cooling Co-Management, And Symbiotic Virtualization, Gopi K. Tummala
Mitigating Multi-Scale Variability In Datacenters: In-Situ Physical Sensing, Proactive Thermal-Cooling Co-Management, And Symbiotic Virtualization, Gopi K. Tummala
Defensive Publications Series
As semiconductor manufacturing scales past the 32 nm threshold toward atomic-scale devices, physical variability has emerged as a paramount challenge threatening computing efficiency, system predictability, and hardware longevity in warehouse-scale datacenters. Nanoscale device scaling introduces severe process variations—such as Random Dopant Fluctuations (RDF) and Line Edge Roughness (LER)—which manifest at the architectural level as a 30% dispersion in core operating frequencies and up to a 10× disparity in sub-threshold leakage power. Compounding these static manufacturing anomalies, datacenters encounter profound dynamic environmental variability, driven by localized heat fluxes exceeding 100W/cm2 , ambient temperature fluctuations (35◦C to 45◦C in containerized and economizer-cooled …
Galois-Q: High-Throughput Finite-Field Microarchitectures For Non-Binary Qudit Qec, Qldpc Syndrome Decoding, And Fault-Tolerant Cryptanalysis, Gopi K. Tummala, Ashwin Alapati, Ram Awatar
Galois-Q: High-Throughput Finite-Field Microarchitectures For Non-Binary Qudit Qec, Qldpc Syndrome Decoding, And Fault-Tolerant Cryptanalysis, Gopi K. Tummala, Ashwin Alapati, Ram Awatar
Defensive Publications Series
Fault-tolerant quantum computing (FTQC) is undergoing a paradigm shift from conventional 2-level qubits toward higher-dimensional d-level qudits (d = q = p m) and asymptotically efficient quantum Low-Density ParityCheck (qLDPC) codes. Non-binary qudits dramatically increase physical quantum information density and reduce cross-talk, while qLDPC codes achieve macroscopic code rates and distance with orders-of-magnitude fewer physical qubits than surface codes. Concurrently, faulttolerant quantum cryptanalysis (such as Shor’s algorithm for discrete logarithms over binary elliptic curves) demands massive reversible modular arithmetic over Galois fields F2m. However, both quantum error correction (QEC) decoding and reversible arithmetic face a severe classical computational bottleneck: processing …
Q-Razor: A Variation-Tolerant, Speculative Classical Control Microarchitecture For Cryogenic Fault-Tolerant Quantum Error Correction, Gopi K. Tummala
Q-Razor: A Variation-Tolerant, Speculative Classical Control Microarchitecture For Cryogenic Fault-Tolerant Quantum Error Correction, Gopi K. Tummala
Defensive Publications Series
Fault-tolerant quantum computing (FTQC) requires classical control processors to execute quantum error correction (QEC) syndrome decoding, Pauli frame updates, and pulse orchestration within microsecond-scale physical qubit coherence windows. To resolve the catastrophic thermal and wiring bottlenecks of routing tens of thousands of microwave coaxial lines from room temperature to a dilution refrigerator, modern architectures place classical control and decoding processors at the 4 Kelvin cryogenic stage. However, 4 K cryogenic CMOS introduces an acute architectural tension: severe carrier freeze-out, amplified random discrete dopant fluctuations (RDF), and localized dynamic thermal hot spots induce up to 3× timing delay variability, while the …
Chesscore: A Reconfigurable Domain-Specific Architecture For Accelerating Adversarial Game-Tree Search And Heuristic Learning, Gopi K. Tummala
Chesscore: A Reconfigurable Domain-Specific Architecture For Accelerating Adversarial Game-Tree Search And Heuristic Learning, Gopi K. Tummala
Defensive Publications Series
Adversarial game-tree search—exemplified by classical zerosum games of perfect information such as Tic-Tac-Toe and Chess—represents a foundational benchmark for artificial intelligence and combinatorial optimization. However, executing recursive minimax algorithms with α-β pruning on generalpurpose von Neumann microprocessors suffers from crippling architectural bottlenecks: branch misprediction rates exceeding 30% during search cutoffs, serialized legal move generation, deep recursion stack thrashing, and high-latency memory stalls during transposition table lookups. This paper presents ChessCore, a reconfigurable domainspecific hardware architecture designed for high-throughput adversarial tree search and heuristic learning. Grounded in an architectural lineage originally prototyped on a resourceconstrained Xilinx Spartan-II FPGA (XC2S50 TQ144) using …
Authoring Drone Camera Moves In An Rtk-Georeferenced 3d Gaussian Splat: Clearance-Certified Waypoint Missions And Survey-Anchored Post-Production Camera Export, Matthew D. Judson
Authoring Drone Camera Moves In An Rtk-Georeferenced 3d Gaussian Splat: Clearance-Certified Waypoint Missions And Survey-Anchored Post-Production Camera Export, Matthew D. Judson
Defensive Publications Series
A method is disclosed in which a real-world site is photographically captured by an uncrewed aircraft (or ground platform) carrying survey-grade GNSS (RTK) positioning; reconstructed as a photorealistic three-dimensional scene representation (such as a 3D Gaussian splat) in a metric frame bound to an Earth-fixed geodetic datum; and then used as the authoring environment for camera moves, such that a keyframed, cinematically parameterized virtual camera path composed inside the reconstruction is (a) validated and compiled into a machine-executable flight mission that a real aircraft flies at true coordinates, (b) certified for obstacle clearance against a conservative geometric over-approximation derived from …
Hexatile: A Scalable Heterogeneous Honeycomb-Tiled Manycore Architecture With Decoupled Multi-Plane Interconnects And Adaptive Hardwalls, Gopi K. Tummala
Hexatile: A Scalable Heterogeneous Honeycomb-Tiled Manycore Architecture With Decoupled Multi-Plane Interconnects And Adaptive Hardwalls, Gopi K. Tummala
Defensive Publications Series
Tiled manycore architectures established a modular paradigm that conquered the global wire-delay wall by decomposing monolithic processors into replicated, network-connected compute elements. Early academic prototypes, such as the MIT Raw microprocessor, and commercial implementations, including Tilera TILE64, TILEPro64, and Tile-Gx 100, proved the viability of pipelined scalar operand networks and 2D mesh on-chip interconnects. However, scaling tiled architectures beyond 100 tiles toward the multi-thousand-tile horizon encounters four crippling bottlenecks: (1) the Cartesian Diameter and Hop-Count Wall in 2D Manhattan meshes, which incurs severe routing latency and packet contention; (2) the Technology Utilization and Dark Silicon Wall, where uniform homogeneous tiles …
Solid State Forms Of (S)-2-(((S)-6,8-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Yl) Amino)-N-(1-(2-Methyl-1-(Neopentylamino)Propan-2-Yl)-1h-Imidazol-4-Yl)Pentanamide Dihydrobromide And Processes For Preparation Thereof, Msn Laboratories Private Limited, R&D Center, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Kommera Rajashekar, Batchanaboina Venkata Subbaiah, Kondeti Raju, Cherukula Srikanth, Badri Lavanya
Solid State Forms Of (S)-2-(((S)-6,8-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Yl) Amino)-N-(1-(2-Methyl-1-(Neopentylamino)Propan-2-Yl)-1h-Imidazol-4-Yl)Pentanamide Dihydrobromide And Processes For Preparation Thereof, Msn Laboratories Private Limited, R&D Center, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Kommera Rajashekar, Batchanaboina Venkata Subbaiah, Kondeti Raju, Cherukula Srikanth, Badri Lavanya
Defensive Publications Series
The present invention relates to solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide dihydrobromide represented by the following structural formula-Ia and processes for preparation thereof.
Low-Energy Conservation Cores With On-Chip Dynamic Power Management For Advanced Computations, Gopi K. Tummala
Low-Energy Conservation Cores With On-Chip Dynamic Power Management For Advanced Computations, Gopi K. Tummala
Defensive Publications Series
Transistor density continues to scale with advances in semiconductor manufacturing, but limits on threshold voltage scaling have brought classical Dennard power scaling to a permanent halt. The resulting technology-imposed “utilization wall” severely restricts the fraction of silicon that can be continuously operated at maximum performance, giving rise to the dark silicon phenomenon. Because reductions in per-operation energy translate directly into increased parallel throughput under fixed thermal envelopes, specialized and heterogeneous architectures have emerged as an imperative. However, conventional parallel accelerators fail when applied to irregular integer codes characterized by tight critical paths, branch-heavy control flow, and poor memory locality. This …
Compiler-Orchestrated Fine-Grained Power Gating And Asymmetric Power Islands For Tiled Spatial Microprocessors, Gopi K. Tummala
Compiler-Orchestrated Fine-Grained Power Gating And Asymmetric Power Islands For Tiled Spatial Microprocessors, Gopi K. Tummala
Defensive Publications Series
As semiconductor technology scales deep into nanoscale dimensions (sub-65 nm), subthreshold leakage current threatens the viability of tiled spatial microprocessors. While spatial architectures—exemplified by the MIT/UCSD RAW processor—elegantly eliminate global wire delays and expose on-chip functional units, interconnects, and pins directly to software, their massive replication of execution resources results in substantial static power waste when application workloads exhibit spatial or temporal underutilization. Traditional reactive dynamic power management (DPM) schemes, such as OS-directed ACPI states or hardware activity timers, fail in spatial architectures due to unpredictable wake-up transition penalties, loss of cycle-level synchronization across scalar operand networks (SONs), and inability …
Techno-Economic Assessment Of Residential Prosumer Systems Using Real Household Consumption Data: A Case Study From Bosnia And Herzegovina, Alen Selmanović, Mehrija Hasičić
Techno-Economic Assessment Of Residential Prosumer Systems Using Real Household Consumption Data: A Case Study From Bosnia And Herzegovina, Alen Selmanović, Mehrija Hasičić
Communications of the IIMA
This paper evaluates the technical, economic, and environmental feasibility of residential prosumer implementation in Sarajevo, Bosnia and Herzegovina, through the integration of photovoltaic (PV) generation and battery energy storage. A simulation‑based assessment was performed in HOMER Pro using a measured 12‑month household load profile with an average daily consumption of 11.25 kWh and a peak demand of 2.85 kW. Six system configurations were investigated, consisting of 3 kW, 4 kW, and 5 kW PV installations, each analyzed with and without a 5.04 kWh lithium‑ion battery, over a 25‑year project lifetime under a zero‑credit export scheme. Among the analyzed configurations, the …
From Dissertation To Deployment: A Unified Software Platform Operationalizing Clinical-Prediction And Sequential-Security Ai For Healthcare, Olsi Shehu, Damiana Teliti, Jasmin Kevrić, Bekir Karlik
From Dissertation To Deployment: A Unified Software Platform Operationalizing Clinical-Prediction And Sequential-Security Ai For Healthcare, Olsi Shehu, Damiana Teliti, Jasmin Kevrić, Bekir Karlik
Communications of the IIMA
Advances in machine learning for healthcare are abundant, yet most validated models remain confined to research notebooks and never reach secure, usable clinical software. This paper addresses that deployment gap by presenting a unified, security-hardened software platform that operationalizes two complementary streams of doctoral research inside a single, role-based hospital information system. The first stream contributes a clinical-prediction capability: an ultra-hybrid ensemble that couples a quantum-inspired feature transformation, particle-swarm feature selection, and calibrated soft voting for cancer-outcome prediction (96.41% accuracy, AUC-ROC 0.983 on TCGA-BRCA), survival stratification, multi-cancer generalization, and pharmacogenomic drug-response classification (89.31% mean accuracy across 25 compounds). The second …
Ai-Based Displacement Forecasting For Real-Time Landslide Risk Assessment In The Danube Region, Amina Čehaja, Asja Muharemović, Jasmin Kevrić, Dejan Jokić, Mirza Ponjavić
Ai-Based Displacement Forecasting For Real-Time Landslide Risk Assessment In The Danube Region, Amina Čehaja, Asja Muharemović, Jasmin Kevrić, Dejan Jokić, Mirza Ponjavić
Communications of the IIMA
This paper presents a dual-layered AI framework for real-time landslide risk assessment developed under the GeoNetSee project within the Interreg Danube Region Programme. The first layer employs a fuzzy logic model, inspired by the Slovenian MASPREM system, which integrates Landslide Susceptibility Maps (LSS) with high-resolution precipitation forecasts from the Open-Meteo API to generate a Predicted Landslide Hazard (PLSH) score on a 0–5 scale, updated every 6–12 hours. The second layer focuses on real-time ground displacement detection by fusing low-cost dual-frequency GNSS receivers with MEMS accelerometers and applying machine learning regression algorithms, including Support Vector Regression (SVR), Long Short-Term Memory (LSTM), …
Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić
Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić
Communications of the IIMA
Fuzzy inference systems have demonstrated considerable promise for EEG-based cognitive state monitoring in neurodegenerative conditions. However, two design decisions significantly influence system performance and clinical applicability: the choice of inference architecture (Takagi-Sugeno vs Mamdani) and the method of rule and membership function generation (manual expert-driven vs data-driven automated). This paper presents a comparative analysis of both dimensions in the context of an EEG-based Alzheimer’s disease monitoring system operating on the ds004504 OpenNeuro dataset (88 subjects: 36 AD, 23 FTD, 29 HC). A Takagi-Sugeno system, implemented as a hybrid FSM-Fuzzy architecture, is compared against a Mamdani equivalent across four axes: inference …
Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian
Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian
The Thai Journal of Pharmaceutical Sciences
Background: Gingivitis is the earliest and most reversible stage of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of plaque. In addition to removing plaque, mouthwash containing antiseptic or anti-inflammatory could be used as an adjunct therapy.
Objectives: The objective of this study is to evaluate the efficacy of a 0.10% standardized Centella asiatica extract (ECa 233) mouthwash compared to 0.12% chlorhexidine and placebo mouthwashes in individuals with gingivitis.
Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 75 patients assigned equally to ECa 233, chlorhexidine, or placebo groups. Participants used the assigned …
Cost Analysis Of Integrated Genderaffirming And Sexual Health Services For Transgender Women In Thailand: Evidence From The Tangerine Clinic, Braprut Sawatwipachai, Kunncadah Anuwong, Nittaya Phanuphak, Rena Janamnuaysook, Kritima Samitpol, Sujin Nitadpakorn
Cost Analysis Of Integrated Genderaffirming And Sexual Health Services For Transgender Women In Thailand: Evidence From The Tangerine Clinic, Braprut Sawatwipachai, Kunncadah Anuwong, Nittaya Phanuphak, Rena Janamnuaysook, Kritima Samitpol, Sujin Nitadpakorn
The Thai Journal of Pharmaceutical Sciences
Background: Transgender women experience a disproportionate burden of human immunodeficiency virus (HIV) globally and in Thailand. Integrating gender-affirming care into sexual health services may improve uptake of HIV and sexually transmitted infections (STIs) testing, treatment, and prevention. Cost data are essential to inform program planning and policy decisions regarding inclusion of such services within Thailand’s Universal Health Coverage (UHC) system.
Objectives: To estimate the full and unit costs of trans-led, integrated gender-affirming and sexual health services along the HIV care cascade.
Methods: Costs of Tangerine Clinic services in 2021 were assessed from the provider perspective, using standard and activity-based costing …
Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee
Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee
The Thai Journal of Pharmaceutical Sciences
Background: Patients with congenital heart disease who have previously undergone right ventricular outflow tract (RVOT) surgery frequently require repeat valve replacement later in life. While transcatheter pulmonary valve replacement (TPVR) offers less invasive reintervention compared with surgery, its high device cost raises concerns about affordability under Indonesia’s National Health Insurance Program (Jaminan Kesehatan Nasional).
Objectives: To compare the cost-effectiveness of surgical pulmonary valve replacement (SPVR) versus TPVR in post-RVOT surgery patients, and to estimate the TPVR price threshold for cost-effectiveness from a societal perspective.
Methods: A Markov model simulated a hypothetical cohort of 15-year-old patients with prior RVOT surgery over …
Anti-Diabetic Activity Of Combination Of Aloe Vera, Allium Sativum, Selenium, And Chromium Picolinate In Alloxaninduced Diabetic Rats, Satyajit Mangate, Syed Ayaz Ali, Zainab Shabbir Shaikh, Mohd Mukhtar Khan, Subur Wadood Khan
Anti-Diabetic Activity Of Combination Of Aloe Vera, Allium Sativum, Selenium, And Chromium Picolinate In Alloxaninduced Diabetic Rats, Satyajit Mangate, Syed Ayaz Ali, Zainab Shabbir Shaikh, Mohd Mukhtar Khan, Subur Wadood Khan
The Thai Journal of Pharmaceutical Sciences
Background: Diabetes mellitus (DM) is a metabolic disorder characterized by deleterious effects on multiple organs. Existing remedial strategies highlight the advancement of herbal and mineral agents to target multiple mechanisms controlling the pathology of DM.
Objectives: This study aims to investigate the hypoglycemic and organ-protective effects of poly-herbal poly-mineral combinations for DM treatment.
Materials and Methods: Five groups of Wistar rats comprising 6 rats in each group were treated with vehicle (sterile water) to control group, alloxan (150 mg/kg, i.p.) to all the groups except the vehicle control group, sitagliptin (40 mg/kg, p.o.) as standard drug treatment, polyherbal polymineral combination …
Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara
Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara
The Thai Journal of Pharmaceutical Sciences
Background: Diphtheria remains endemic in parts of Thailand and continues to threaten unvaccinated populations. To strengthen vaccine self-sufficiency, the Government Pharmaceutical Organization has developed in-house diphtheria–tetanus–pertussis (DTP) and diphtheria– tetanus (dT) vaccines. Potency testing of diphtheria toxoid is traditionally performed in guinea pigs; however, limitations in animal availability, cost, and logistics have prompted evaluation of alternative models.
Objectives: To compare diphtheria toxoid potency estimates of in-houseproduced DTP and dT vaccines using guinea pigs and mice, followed by a Vero cell-based toxin neutralization assay, and to assess the suitability of mice as an alternative model for potency testing.
Materials and Methods: …