Digital Commons Network^™

Contingent Fees To Contain Bank Runs, Rafael Matta, Remo Oostdam, Enrico Perotti

Documents

No abstract provided.

Effects Of Obesity On Plasma Biomarker And Amyloid Pet Trajectories In Alzheimer's Disease, Soheil Mohammadi, Farzaneh Rahmani, Mahsa Dolatshahi, Suzanne E Schindler, Cyrus A Raji, Adni Collaborators

2020-Current year OA Pubs

INTRODUCTION: Obesity is a risk factor for Alzheimer's disease (AD), but its impact on AD blood biomarker (BBM) and amyloid positron emission tomography (PET) trajectories is unknown.

METHODS: One thousand two hundred twenty-eight plasma samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were assessed using six leading commercial tests (C2N, Fujirebio, Janssen, ALZpath, Roche, and Quanterix). Amyloid PET scans were used to assess amyloid burden in Centiloids (CLs). Spearman partial correlations assessed cross-sectional associations, while linear mixed-effects models examined the longitudinal impact of obesity status on BBMs and CLs.

RESULTS: Higher body mass index at baseline was correlated with lower …

Discovering Subtypes With Imaging Signatures In The Motoric Cognitive Risk Syndrome Consortium Using Weakly Supervised Clustering, Bhargav Teja Nallapu, Kellen K Petersen, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Understanding the heterogeneity of brain structure in individuals with the Motoric Cognitive Risk Syndrome (MCR) may improve the current risk assessments of dementia.

METHODS: We used data from six cohorts from the

RESULTS: Three subgroups (Groups A, B, and C) were identified through MRI-based clustering with significant differences in regional brain volumes, gait speeds, and performance on Trail Making (Part-B) and Free and Cued Selective Reminding Tests.

DISCUSSION: Based on structural MRI, our results reflect heterogeneity in the population with moderate and slow gait, including those with MCR. Such a data-driven approach could help pave new pathways toward dementia …

She Speaks: Amplifying Women's Voices For Wellbeing, Narelle Lemon

Reports accepted as research outputs

Executive Summary

The SheSpeaks project successfully transformed how 223 Western Australian women understand and practice self-care, demonstrating  that targeted wellbeing literacy interventions can create lasting change  in women’s relationship with their own wellbeing. Funded by the Women’s Grants for a Stronger Future program, this innovative initiative combined evidence-based workshops with authentic podcasting to challenge the pervasive cultural narrative that positions women’s self-care as selfish  or impossible.

The Eurosystem’S Instruments, European Central Bank (Ecb)

Documents

No abstract provided.

Resisting Neoliberalism: Testimonios Of Language Teachers As Social Activists, David Martinez-Prieto

Bilingual and Literacy Studies Faculty Publications

This study examines the testimonios of Mexican language teachers who experienced the violent and institutional imposition of neoliberal policies at the main university at the state of Puebla. Through the analysis of testimonios, language teachers narrated their own trajectories to resist the implementation of the neoliberal policies, such as the restriction of teaching freedom for educators, the elimination of the right to free education for students, and the current subjugation educators experience at the site of study. Based on the Foucauldian concepts of sovereign and institutional power, along with governmentality, this article analyzes the activism of language teachers, and …

Decolonizing Educational Research: Pláticas As Sites Of Reciprocity, Vulnerability, And Reflexivity, Miryam Espinosa-Dulanto

Bilingual and Literacy Studies Faculty Publications

No abstract provided.

Ni1 Demonstrates Anti-Tumor Activity In Group 3 Pediatric Medulloblastomas, Julia Dziekan, Maria Burkovetskaya, Ranjana Kanchan, Abhishek Bhattacharya, Sidharth Mahapatra

Posters: 2025 Summer Undergraduate Research Program

Medulloblastoma is one of the most common malignant pediatric brain tumors, typically arising in the cerebellum of children between the ages of 3 and 8 years. Of the four subgroups, group 3 is the most aggressive, with a < 50% 10-year overall survival rate. In group 3 medulloblastoma, alterations to chromosome 17 can result in an isochromosome (i17q) and haploinsufficiency of the 17p13.3 region. This locus houses miR-1253, a tumor suppressor gene that regulates CD276 (B7-H3), an immunomodulatory protein implicated in cancer aggressiveness. Silencing miR-1253 can trigger overexpression of B7-H3, leading to immune suppression and increased tumor growth. In this study, we investigated a small molecule inhibitor of B7-H3, B7-H3-Ni1 (Ni1). Group 3 MB cancer cells (HDMB03) were treated with varying concentrations of Ni1. The effects of Ni1 on viability, proliferation, and stemness were assessed using MTT ( 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), wound healing (scratch), and colony formation assays, respectively. Ni1 induced a dose-dependent reduction in proliferation and viability, alongside a significant impairment in cellular migratory ability. These findings suggest that Ni1 affects key oncogenic behaviors in group 3 medulloblastoma cells, warranting further investigation as a potential targeted therapeutic.

Editors’ State Of The Journal, Nancy E. Krusen, Stacy Smallfield, M Nicole Martino

Translational Science in Occupation

No abstract provided.

The Power Of Podcasting In Knowledge Translation For Occupational Therapy, Matthew C. Brandenburg

Translational Science in Occupation

No abstract provided.

Value Of Case Studies For Translating Evidence In Occupational Therapy: A New 3-Dimensional Model, George S. Tomlin, Bonnie Riley, Aimee Piller, Jessica Mchugh Conlin, Ashlea D. Cardin, Katrina M. Serwe, Deborah A. Dougherty

Translational Science in Occupation

Importance: Occupational therapy (OT) practitioners often address complex occupational performance needs of diverse consumers. Professional reasoning, theory, and trial and error interventions can be demonstrated in case studies. Case studies are usually relegated to the lowest level in evidence hierarchies. Yet they have a long tradition in health care literature, and may particularly document the holism, inclusivity, uniqueness, and complexity of OT practice.

Objective: To determine how case studies make a distinct contribution to professional knowledge, using a new model for categorizing them.

Evidence Review: 103 case studies published in AJOT from 1990-2023 were rated by the authors “1” or …

Translating Knowledge Of Functional Cognition Into Occupational Therapy Practice, Mckenzie R. Behrendt, Emilea Rogers, Azia Ourada, Sara Mengler, Mackenzie Post, Stacy Smallfield

Translational Science in Occupation

Functional cognition is a critical component for safely and effectively performing daily occupations. Occupational therapy (OT) practitioners are uniquely positioned and trained to address functional cognition while considering a client’s abilities and environments. A multimedia e-learning module was developed as a teaching modality to enhance understanding and application of functional cognition concepts for OT students and practitioners. As educators, it is important to assess the effectiveness of the teaching and learning experiences we create. We evaluated the multimedia e-learning module for quality, value, and usefulness using critical reflection perspectives. These perspectives included a literature review, as well as from learner, …

Gazing In The Mirror: Reflecting On Student Perspectives In Work-Integrated Learning In Healthcare Education, Cassidy P. Johnson, Simone C. Regnier, Leah M. Stade Otd, Mhptt, Otr/L

Translational Science in Occupation

Abstract: Student engagement is typically woven into the curriculum of healthcare education through hands-on experiences, lectures, discussions, active learning, and lab components. This engagement is critical to developing student confidence, efficacy, and esteem in important skills that will serve them as they enter their profession. In our doctoral program, we are allowed additional engagement opportunities, including belonging to a research project with professionals. Upon reflection, our experience on an interprofessional research team has helped to translate our classroom knowledge to research and professional practice skills.

Plain-Language Summary: This paper is a reflection on the value of adding work skills beyond …

Retrospective Chart Review Of The Acute Care Psychosocial Evaluation Process For Females Diagnosed With Breast Cancer, Kimberly Conrad, Lou Jensen, Shelley Ashcroft, Antoine Bailliard, Vanessa D. Jewell

Translational Science in Occupation

Background: A breast cancer diagnosis can significantly impact an individual’s quality of life. This retrospective chart review explored the occupational therapy evaluation process with female patients in an inpatient acute care hospital with a breast cancer diagnosis.

Methods: This descriptive retrospective chart review analyzed 134 occupational therapy evaluations of female patients with breast cancer admitted to a southeastern US academic medical center. Data were extracted and categorized using the Occupational Therapy Practice Framework.

Results: The most frequently administered assessments were non-standardized and the AM-PAC "6-Clicks." Documented short-term goals primarily focused on self-care (56.6%), gross motor skills (24.7%), and instrumental activities …

Exploration Of Learning Preferences For Parents Of Children With Sensory Over-Responsivity: A Mixed-Methods Study, Lisa M. Porter, Shelly J. Lane, Barbara B. Demchick, Jane K. Sweeney, Breanne Kearney

Translational Science in Occupation

Importance: Parent education is essential to pediatric occupational therapy (OT), yet there is a paucity of research regarding how to best support parents as adult learners.

Objective: To explore the learning experiences of parents of children with sensory over-responsivity (SOR).

Methods: An embedded mixed-methods design was used. Sixteen parents of children with SOR, aged 3–8 years, were recruited using purposive sampling. All parents participated in group trainings; of these, nine participated in one-on-one interviews. Quantitative data included pre-intervention parenting self-efficacy (PSE) scores and post-intervention learner satisfaction measures. Semi-structured interviews were used to explore parents’ learning experiences during …

Perceptions And Barriers Of Vestibular Rehabilitation Among Occupational Therapy Practitioners, Rebecca Callais

Translational Science in Occupation

Background: Vestibular dysfunction affects 15-20% of adults annually, often impacting daily activities and quality of life (Neuhauser, 2016). While occupational therapists and occupational therapy assistants (OTs/OTAs) can address functional limitations caused by vestibular disorders, their role in vestibular rehabilitation (VR) is under-studied.

Objective: This study explored the competence and confidence of occupational therapy practitioners (OTP) in VR and identified barriers to implementation.

Methods: A cross-sectional survey was distributed to 532 OTP in the Gulf South region, with 79 responses received. The survey included questions on VR training, techniques used, barriers of implementation in practice, and educational supports. Quantitative data were …

Integration Of The Science Of Team Science (Scits) With Applied Healthcare Frameworks: Interprofessional Education Through A University-Based Head Injury Clinic, Part I: Theory, Emily Balog, Susan Paparella, Natalia Noce, Stephanie Hubbell, Kelly Pena

Translational Science in Occupation

Background: Wicked problems in healthcare, such as the complex health condition of head injury, demand interprofessional collaboration that transcends traditional disciplinary boundaries. These complex clinical challenges call for theoretical frameworks that integrate both disciplinary expertise and interdisciplinary processes.

Definitions and Concepts: Grounded in Repko and Szostak’s (2017) framework of interdisciplinary studies, this paper integrates the Science of Team Science (SciTS), the Interprofessional Education Collaborative (IPEC) competencies, and TeamSTEPPS® to construct a novel heuristic that informs the design of an interprofessional education (IPE) and practice model.

Relationships Between Concepts: We align SciTS’ four phases with IPEC and TeamSTEPPS® to enhance team-based …

Effect Of The Development Of Social Networks On Expansion Of Social Entrepreneurship: Moderating Role Of Digital Technology Infrastructure And Social Norms, Mahdi Maskani, Reza Mohammadkazemi, Fargol Saberi Qomi

AMTP Proceedings 2025

In today's era, social networks, which are an effective tool in promoting ideas and innovations, have met with global acceptance and popularity. The communication that is formed between people in society through them can be the basis for ideas and opportunities for social entrepreneurship and voluntary social activities, and it is expected that this global platform will be the basis for the expansion of social entrepreneurship. The study aimed to examine the effect of the development of social networks on the expansion of social entrepreneurship by explaining the moderating role of digital technology infrastructure and social norms. The findings revealed …

The Future Performance Implications Of Non-Gaap Motivated Investment, Minkwan Ahn, Theodore E. Christensen, Ryan G. Johnson, Melissa F. Lewis-Western

Faculty Publications

We investigate whether consistent non-GAAP reporting is associated with investment efficiency. Prior research finds a positive association between non-GAAP reporting and investment levels, concluding that it represents overinvestment. We corroborate this positive association, but additional tests are not consistent with the conclusion of inefficient overinvestment. Specifically, we explore the relation between investment and future cash flows as a proxy for the realization of investments in positive net present value projects. We find that the investments of firms that consistently report non-GAAP metrics are associated with similar or higher future cash flows than the investments of firms reporting only GAAP earnings, …

The Development Of A Rag-Based Artificial Intelligence Research Assistant (Aira), Hamid Vakilzadeh, David A. Wood

Faculty Publications

No abstract provided.

C 3 An: Custom, Compact And Composite Ai Systems - A Neurosymbolic Approach: 4Th-Generation Evolution Of Intelligent Systems, Amit P. Sheth, Kaushik Roy, Revathy Venkataramanan, Venkatesan Nadimuthu

Publications

Artificial Intelligence (AI) systems continue to evolve rapidly. From the architecture perspective, it is evolving from large, monolithic models trained on massive internet data to complex, multi-component “compound” systems and “agentic” frameworks capable of semi-autonomous decision-making. These systems show immense promise yet face numerous challenges in reliability, consistency, transparency, and alignment with user goals. In this article, we propose Custom, Compact and Composite AI with Neurosymbolic (C3AN) approach, a framework that paves way to 4th-generation of AI that integrates data, knowledge, and human expertise to build robust, intelligent and trustworthy AI systems defined by 14 foundation elements.

Custom emphasizes …

Safe Data-Enabled Control Of Human-In-The-Loop Robotic Manipulator Systems, Ritirupa Dey, Avimanyu Sahoo, Vignesh Narayanan

Publications

Safe control of human-in-the-loop (HIL) robotic manipulators is critical for applications such as assistive robotics, teleoperation in hazardous environments, and collaborative manufacturing. However, this remains challenging due to the lack of a unified framework that simultaneously addresses safety constraints, external disturbances, unmodeled dynamics, and dynamic role switching in the HIL setting. In this paper, we propose a novel NN-driven HIL control framework in which human–robot dyadic interaction occurs through the haptic channel. Using Lyapunov stability analysis, we theoretically show that the proposed NN-based controller ensures accurate joint trajectory tracking, compensates for system uncertainties, and adapts to human inputs modeled as …

New York Environmental Legislation In 2024, Michael B. Gerrard

Faculty Scholarship

In 2024, New York State enacted several laws aimed either at dealing with the adverse impacts of climate change such as extreme heat and increasingl severe and frequent storms or at helping to mitigate greenhouse gas emissions to avoid or minimize the adverse impacts. The final bill signed by Governor Kathy Hochul in 2024 was the most high-profile of these laws — the Climate Change Superfund Act, which will require fossil fuel companies to pay for adaptation measures.

Other new laws last year related to extreme heat in schools and prisons, food waste, expanded polystyrene containers, community gardens, and native …

Loper Bright And The Great Writ, Anthony G. Amsterdam, James S. Liebman

Faculty Scholarship

Chevron deference is dead. The Court’s forty-year, seventy-decision experiment with Article-III-court deference to “reasonable” agency interpretations of ambiguous federal statutes failed, killed in part by concern that it unduly curbed the “judicial Power” to enforce the rule of law in the face of politics, partisanship, and mission-driven agency decision-making.

“AEDPA deference” lives. The Court’s twenty-five-year, seventy-two decision experiment with Article-III-court deference to “reasonable” state-court interpretations of the Constitution under the 1996 Antiterrorism and Effective Death Penalty Act continues to relegate criminal defendants to prison or death, notwithstanding federal habeas judges’ independent judgment that the state courts have misread or misapplied …

In Search Of A State, Maeve Glass

Faculty Scholarship

This article offers a legal history of one of America’s earliest campaigns of state legislative resistance: the effort in Massachusetts to protest the national government’s perceived dismantling of an old Atlantic commercial order from 1803 to 1815. To date, scholars have either condemned this protest as a dangerous harbinger of the Civil War or vindicated it as an inevitable and salutary extension of the Founding. This article steers a different course. By focusing on the evolving language of protest and the complex hybrid of ideas and material realities from which this language emerged, this article illuminates how Federalist leaders who …

Examining And Classifying Reasons For Missing Viral Loads Among Adults Living With Hiv: An Extended Outcome Investigation And Ascertainment Approach In Western Kenya, Harriet Fridah Adhiambo, Jayne Lewis-Kulzer, Edwin Nyagesoa, Sarah Gimbel, Eliud Akama, Dorothy Mangale, Lina Montonya, Ingrid Eshun-Wilson, Sarah Iguna, Everlyne Nyandieka, Elizabeth Bukusi, Lisa Abuogi, Thomas Odeny, Maya L. Petersen, Elvin H. Geng

2020-Current year OA Pubs

Gaps in HIV RNA monitoring persist globally impeding the ability to determine clinical progress and outcomes. This study systematically evaluated provider (e.g., guideline non-adherence), system (e.g., laboratory error) and participant-level (e.g., refusal) drivers of missed viral load (VL) monitoring measurements among people with HIV in Kenya. Adults aged 18-65 years were followed across five health facilities in Kenya as part of a clinical trial (NCT#02338739) where HIV RNA monitoring was done routinely. Instances of missed VL despite being indicated per Kenyan guidelines were identified. An algorithm for assessing root causes of missing HIV RNA was developed and generalized linear models …

How Artificial Intelligence Will Shape Securities Regulation, Gabriel Rauterberg

Faculty Scholarship

How will the increasing prevalence and sophistication of artificial intelligence (AI) change the doctrine and practice of securities law? My main thesis is that it will push securities regulation toward a more systems-oriented approach. This approach will replace securities law’s emphasis, in areas like manipulation, on forms of enforcement targeted at specific individuals and accompanied by punitive sanctions with a greater focus on ex ante rules designed to shape an ecology of actors and information.

Altering Rules: The New Frontier For Corporate Governance, Gabriel Rauterberg, Sarath Sanga

Faculty Scholarship

Corporate law has taken a contractarian turn. Shareholders are increasingly contracting around its foundational rules — statutory rights, the fiduciary duty of loyalty, even the central role of the board — and Delaware courts are increasingly enforcing these contracts. In the one case where they did not, the legislature swiftly overruled the decision and adopted a new statutory provision permitting boards to completely cede their powers to a shareholder by contract. These developments have sparked a polarized debate, with some calling for a return to mandatory rules, while others push for total contractual freedom.

We argue, however, that the best …

Competitive Populism, Madhav Khosla

Faculty Scholarship

The preoccupation of comparative constitutional lawyers over the past decade or so has been the rise of authoritarian populism. This chapter focuses on one possible pathway that might follow our present political moment: competitive populism. This phase will involve a certain kind of institutional vacuum: the prior institutions, associated with liberal constitutional democracy, will not lend themselves to being rebooted. In reflecting on this possible future, this chapter explores the nature and form of deinstitutionalization that has occurred under authoritarian populism, and the elements that define the emerging constitutional framework. The implication here is that what will be crucial …

For Whose Benefit Is The Freedom Of Speech?, Vincent A. Blasi

Faculty Scholarship

In United States v. Alvarez, the US Supreme Court ruled that an official of a water district who introduced himself to his constituents by falsely stating in a public meeting that he had earned the Congressional Medal of Honor had a First Amendment right to make that demonstrably untrue claim. Audience members misled by the statement might well be considered to have a First Amendment interest in not being directly and knowingly lied to in that way. Other members of the community might be thought to have a First Amendment interest in public officials such as Xavier Alvarez telling …