Digital Commons Network^™

Kinetic Model Of Glycolysis And Glutaminolysis Interplay Developed In Matlab Simbiology, Zohreh Mirveis, Hugh J. Byrne, Nitin Patil

Datasets

This dataset contains a kinetic model developed in MATLAB SimBiology to simulate the metabolic dynamics of glycolysis and glutaminolysis and their interconnection. The model was used in the study ‘Experimental and computational investigation of the kinetic evolution of the glutaminolysis pathway and its interplay with the glycolysis pathway’ (Mirveis et al., 2024). The dataset includes the original SimBiology project file together with the experimental data used for model training. These resources enable reproduction of the simulations reported in the publication and provide a reusable framework for further computational exploration of metabolic pathway kinetics.

Interpreting The Latent Space Of A Convolutional Variational Autoencoder For Semi-Automated Eye Blink Artefact Detection In Eeg Signals, Sabatina Criscuolo, Andrea Apicella, Roberto Prevete, Luca Longo

Articles

Electroencephalography (EEG) allows the investigation of brain activity. However, neural signals often contain artefacts, hindering signal analysis. For example, eye-blink artefacts are particularly challenging due to their frequency overlap with neural signals. Artificial intelligence, particularly Variational Autoencoders (VAE), has shown promise in EEG artefact removal. This research explores the design and application of Convolutional VAEs for automatically detecting and removing eye blinks in EEG signals. The latent space of CVAE, trained on EEG topographic maps, is used to identify latent components that are selective for eye blinks. Receiver Operating Characteristic (ROC) curves and Area Under the Curve (AUC) are employed …

The Digital Loophole: Evaluating The Effectiveness Of Child Age Verification Methods On Social Media, Fatmaelzahraa Eltaher Ph.D, Rahul Gajula, Luis Miralles-Pechuán, Christina Thorpe, Susan Mckeever

Conference papers

Social media platforms are an integral part of daily life for nearly five billion people worldwide. However, the growing presence of underage users on these platforms raises significant concerns regarding children's exposure to harmful content and its impact on their mental health. This paper examines the effectiveness of age verification measures implemented on leading platforms Facebook, YouTube, Instagram, TikTok, Snapchat, and X. We evaluate the age verification processes required for account creation by simulating the registration steps for minors on these platforms. We also compare these methods to best practices in online age assurance in finance, betting and public transportation …

Heat Generation In Perovskite/Cztsse Tandem Solar Cells, Mohammad Bahrami, Mohammad Mahdi Najafali, Javad Maleki, Fatemeh Khalaji, Mansour Kanani, Mohammad Moaddeli, Nima E. Gorji

Research Outputs: 2025-Present

Tandem of Perovskite and other materials for solar cell structure have attracted the attention of many researchers. Here, we developed a strong coupled model to investigate the heat generation and thermal stability of Perovskite/CZTSSe Tandem Solar Cells. Studying the opto-electro-thermal (OET) properties of tandem solar cells is essential to better understand the optical absorption, carrier transport, and their thermodynamic behavior. In recent years, thermal losses in solar cells have received more attention and heat generation in solar cell structure has said to be effective on long-term stability and performance. Temperature distribution and heat generation of tandem solar cells has been …

Workshop - Supercharging Your Engineering Classes With Ethics!, Shannon Chance

Research Outputs: 2025-Present

Are you ready to energize your students’ learning of engineering ethics? Join us for a high-voltage, interactive workshop where we’ll unlock the power of the Routledge International Handbook of Engineering Ethics Education—an opensource treasure trove of cutting-edge knowledge and active learning strategies!This dynamic workshop is designed for educators who want to infuse their courses with innovative, discipline-specific ethics learning methods. Through gamified exploration, creative brainstorming, and collaborative problem-solving, you’ll walk away with practical strategies to integrate ethics into any engineering course.We’ll kick things off with a dynamic guided tour of the handbook, unveiling its structure and offerings. Then, we’ll divide …

Aspen Plus Modelling Of The Milena Dual Fluidised Bed Biomass Gasifier Technology, Mohadeseh Naderi, Hamid Rashidi, Anthony Reynolds, Wayne Doherty

Research Outputs: 2025-Present

The Energy Research Centre of The Netherlands is developing MILENA gasification technology to convert biomass fuels into high-value gaseous and liquid products. MILENA is a steam-blown dual fluidised bed (DFB) gasification process with separate gasification and combustion zones. This DFB gasifier produces high-quality gas with low N₂ content suitable for vehicle fuel or natural gas grid injection. This study presents a semi-kinetic Aspen Plus model for MILENA gasification, including stages like drying, rapid pyrolysis, gasification, combustion, and tar cracking and reforming. Pyrolysis as a key step, was modelled using experimental data for the rapid pyrolysis of wood to calculate …

Bioinspired Gradient Porous Hip Implant Design To Prevent Stress Shielding Using Stress Mapping And Bone Remodeling Theory, Babak Ziaie, Xavier Velay, Waqas Saleem

Research Outputs: 2025-Present

Total Hip Arthroplasty (THA) is a widely performed surgical procedure, with increasing frequency worldwide. Despite its high success rate, many patients require revision surgeries due to complications such as aseptic loosening, primarily resulting from stress shielding, cortical hypertrophy, and micromotion. These issues often stem from a mechanical mismatch between the bone and the solid dense implant, particularly a mismatch in stiffness. A potential solution lies in the use of porous or lattice structures in implant design, which offer lower stiffness and improved biocompatibility by facilitating bone ingrowth, cell seeding, and vascularization. Among these designs, Triply Periodic Minimal Surfaces (TPMS), especially …

Techmate: A Toolkit For Advancing Gender Equality In Computing Education, Alina Berry

Academic Posters Collection

To address the issue of gender inequality in computing education.

To inspire and guide institutions to implement change and track progress with easy to follow guidance.

To provide champions with useful and easy to access resources.

Conversations In The Classroom: Increasing Dialogic Inquiry To Dismantle Compliance-Based Teaching And Learning, Jill Rivera

West Chester University Graduate Theses, Dissertations, and Final Projects

Verbal interpersonal communication has been diminishing from the teaching and learning process over the past decade in public-school classrooms. School district administrations mandate teachers to utilize digital learning platforms and standardized tests due to the ease at which this technology can quickly gather data. While the transition to digital platforms and test-based education may be well-intended, the result has often been a decrease in dialogic inquiry-based pedagogy which removes teacher autonomy, student agency, and has negative effects on students’ ability to critically think and effectively engage in communication and instruction. The over-emphasis on collecting data based solely on a digitized …

Exploring Mental Health Concerns And Loneliness Among East Asian International Students In U.S. Universities, Shihan Xu

Antioch University Dissertations & Theses

This study examined the unique stressors encountered by international college students, with particular attention to East Asian international students, whose collectivistic cultural values contribute to their mental health status and reported symptoms. Following the COVID-19 pandemic, the rise in stress levels and loneliness highlighted the need for further examination. Using data collected in 2024 through the Counseling Center Assessment of Psychological Symptoms-34 (CCAPS-34) and the UCLA Loneliness Scale, the study surveyed East Asian international students enrolled in universities in the United States to identify prevalent mental health concerns and explore the correlation between loneliness and self-reported symptoms among East Asian …

21st-Century Stewardship: Infusing Environmental Education With Global Citizenship, Ava Y. Goodale

Antioch University Dissertations & Theses

In today's interconnected world, where socioecological issues transcend political borders, integrating environmental stewardship education with global citizenship education offers valuable opportunities for student empowerment. The goal of this multi-article dissertation was to conceptualize and operationalize 21st-century stewardship in educational settings. Twenty-first-century stewardship is a pedagogical approach that recognizes the limitations of environmental stewardship education as it is traditionally taught and is defined in Chapter II as an updated stewardship model that is infused with global citizenship’s multiscalar perspectives, global compacts, and layered identities to achieve its maximum impact in our interconnected world. This goal was first accomplished in Chapter II …

High-Speed Aircraft Stability And Control Metrics, Timothy T. Takahashi, Jack A. Griffin, Ramana Grandhi

Faculty Publications

This review paper identifies key stability and control screening parameters needed to design low-risk, general-purpose high-speed aircraft. These derive from MIL-STD-8785C, MIL-STD-1797, and older AGARD reports, and are suitable for assessing conceptual high-speed vehicles. We demonstrate their applicability using published ground test, computation, and flight test data from the Bell X-2, North American X-15, Martin X-24A, Northrop HL-10, Lockheed Blackbird (YF-12/SR-71), and North American XB-70 as well as the Rockwell Space Shuttle Orbiter. The relative success of the X-15 and Blackbird and the performance limitations of the others indicate the need to scrutinize lateral-directional stability at the preliminary design phase. …

Volume 40 (2025-2026)

EILR Masthead Archive

No abstract provided.

Patterns Of Inpatient Antibiotic Utilization By Race And Ethnicity At Us Children’S Hospitals, Bethany A. Wattles, Jeffrey I. Campbell, Theresa Kluthe, Yana B. Feygin, Kahir Jawad, Michelle D. Stevenson, Deborah Winders Davis, Jennifer Porter, V. Faye Jones, Matt Hall, Michael J. Smith

Biostatistics Faculty Publications

Background and Objectives: Racial and ethnic variations in antibiotic utilization are well-reported in outpatient settings but little is known about inpatient settings. Our objective was to describe national inpatient antibiotic utilization among children by race and ethnicity. Methods: This study included hospital visit data from the Pediatric Health Information System between 01/01/2022 and 12/31/2022 for patients <20 years. Primary outcomes were the percentage of hospitalization encounters that received an antibiotic and antibiotic days of therapy (DOT) per 1000 patient days. Mixed-effect regression models were used to determine the association of race-ethnicity with outcomes, adjusting for covariates. Results: There were 846,530 hospitalizations. 45.2% of children were Non-Hispanic (NH) White, 27.1% were Hispanic, 19.2% were NH Black, 4.5% were NH Other, 3.5% were NH Asian, 0.3% were NH Native Hawaiian/Other Pacific Islander (NHPI) and 0.2% were NH American Indian. Adjusting for covariates, NH Black children had lower odds of receiving antibiotics compared to NH White children (aOR 0.96, 95%CI 0.94–0.97), while NH NHPI had higher odds of receiving antibiotics (aOR 1.16, 95%CI 1.05–1.29). Children who were Hispanic, NH Asian, NH American Indian, and children who were NH Other received antibiotic DOT compared to NH White children, while NH NHPI children received more antibiotic DOT. Conclusions: Antibiotic utilization in children’s hospitals differs by race and ethnicity. Hospitals should assess policies and practices that may contribute to disparities in treatment; antibiotic stewardship programs may play an important role in promoting inpatient pharmacoequity. Additional research is needed to examine individual diagnoses, clinical outcomes, and drivers of variation.

A Demographic Description Of Children And Adolescents With Concomitant Autism And Anxiety Along With A Comparison Of Receipt Of Psychological Services, Elizabeth Salt, Amanda T. Wiggins, David N. Toupin, Emma Parks, Chizimuzo Okoli, Mary Kay Rayens

Biostatistics Faculty Publications

Objective:(1) Evaluate differences in demographic distributions between those with autism alone and those with autism concomitant with anxiety and (2) assess demographic factors associated with receipt of psychological therapy in patients with autism.Methods:Using deidentified health care claims data, we extracted all encounters among children with the International Classification of Diseases-10-CM for Autism Spectrum Disorder (F84) and flagged those with concomitant anxiety (F41.9). Extracted data included age, sex, race, ethnicity, insurance status, and Rural-Urban Continuum Codes. Current procedural terminology codes for psychological services were extracted. Data were analyzed using Mann-Whitney U tests, χ² tests of association, and logistic regression.Results:Demographic differences …

Leveraging Machine Learning Models To Explore Disparities In Prostate Cancer Diagnosis, Treatment, And Survival, Reuben Adatorwovor, Rasaq Oladapo, Parisa Ghasemi, Gaurav Kumar, Daniel J. Morton, Motolani E. Ogunsanya, Olufunmilola Abraham

Biostatistics Faculty Publications

Introduction: Prostate cancer (CaP) is the second most common cancer in men globally and a leading cause of cancer-related mortality, particularly among older men. In the United States, disparities in incidence, stage at diagnosis, and outcomes persist across racial, socioeconomic, and geographic lines. Men in medically underserved regions like Appalachia experience higher mortality due to limited access to timely screening and treatment. Given the complex interplay of clinical, behavioral, and sociodemographic factors, machine learning (ML) offers promise in identifying survival predictors that traditional models may overlook. This study applies ML models to assess the impact of age at diagnosis, treatment …

Outcomes Of A Pilot Randomized Clinical Trial Testing Brief Interventions To Increase Hiv Pre-Exposure Prophylaxis Uptake Among Rural People Who Inject Drugs Attending Syringe Services Programs, Hilary L. Surratt, Sarah Brown, Abby L. Burton, Will Cranford, Laura C. Fanucchi, Christie Green, Stephanie M. Mersch, Rebecca Rains, Philip M. Westgate

Biostatistics Faculty Publications

Background: Kentucky is one of seven states with high, sustained rural HIV transmission tied to injection drug use. Expanding access to pre-exposure prophylaxis (PrEP) has been endorsed as a key HIV prevention strategy; however, uptake among people who inject drugs (PWID) has been negligible in rural areas. Syringe services programs (SSPs) have been implemented throughout Kentucky’s Appalachian region, providing an important opportunity to integrate PrEP services. Objectives: The primary objective was to examine preliminary efficacy and effect sizes of the study interventions on PrEP initiation among HIV-negative PWID. Design: Parallel group randomized controlled trial. Methods: Eighty participants were enrolled from …

Clinical Criteria For Limbic-Predominant Age-Related Tdp-43 Encephalopathy, David A. Wolk, Peter T. Nelson, Liana Apostolova, Konstantinos Arfanakis, Patricia A. Boyle, Cynthia M. Carlsson, Nick Corriveau-Lecavalier, Penny Dacks, Bradford C. Dickerson, Kimiko Domoto-Reilly, Brittany N. Dugger, Rebecca Edelmayer, David W. Fardo, Michel J. Grothe, Timothy J. Hohman, David J. Irwin, Gregory A. Jicha, David T. Jones, Claudia H. Kawas, Edward B. Lee, Karen Lincoln, Gladys E. Maestre, Elizabeth C. Mormino, Chiadi U. Onyike, Ronald C. Petersen, Gil D. Rabinovici, Rosa Rademakers, Rema Raman

Biostatistics Faculty Publications

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of …

Code Status Discussions, Hunter Bechtold, Reagan T. Smith, Peter Wallenhorst, Kaylee Gouge, Sarah Schaefer, Kelsey Karnik, Kristen Mcquerry, Kristen E. Fletcher

Biostatistics Faculty Publications

Introduction: Residents frequently conduct code status discussions (CSDs) with patients, but many report not receiving formal training in this skill. While institutions have attempted to address this, there remains a need for a curriculum that uses standardized patients (SPs), is generalizable to students interested in different medical specialties, and has been tested on a large sample of students. Methods: We trained 192 fourth-year medical students across four different campuses in how to conduct CSDs during one 2-hour workshop as part of their Transition to Residency course in April 2024. Students worked with SPs as part of this workshop. Students at …

How Patient, Infection, And Cysticercus Characteristics Impact The Evolution Of Taenia Solium Larva In The Human Brain, Hongbin Zhang, Meghana G. Shamsunder, Pryanka Bawa, Arturo Carpio, W. Allen Hauser, Karina Quinde-Herrera, Alex Jaramillo, Elizabeth A. Kelvin

Biostatistics Faculty Publications

Neurocysticercosis is a poorly understood infection of the central nervous system with Taenia solium larva and treatment often fails to kill all the parasitic larva. Most research on this infection has used patient-level data, looking at summaries of the encysted parasitic cysticercus burden. Cyst-level analysis is needed to identify factors that impact individual cyst trajectories and how that may vary based on characteristics of the patient, infection, and cyst being followed. We disaggregated data on 221 cysts from 117 patients who participated in a trial evaluating the impact of albendazole treatment to identify factors that impact cyst evolution over time …

A Myostatin Inhibitory Antibody Combined With Insulin, Partially Rescues The Musculoskeletal Phenotype Of Female Insulin-Deficient Diabetic Mice, R. Clay Bunn, Reuben Adatorwovor, Philip D. Ray, Alexander R. Keeble, Christopher S. Fry, Sasidhar Uppuganti, Jeffry S. Nyman, John L. Fowlkes, Evangelia Kalaitzoglou

Biostatistics Faculty Publications

Introduction: Type 1 diabetes is associated with deficits in both skeletal muscle and bone. Inhibition of myostatin, a negative regulator of muscle mass, was explored as a druggable target to improve the musculoskeletal phenotype associated with insulin-deficient diabetes in female mice. Methods: We investigated whether administration of an inhibitory myostatin antibody (MyoAb) in streptozotocin-induced diabetes in female mice is protective for skeletal muscle and bone. DBA/2J female mice were injected with low-dose streptozotocin or with citrate buffer (vehicle). Subsequently, mice were implanted with insulin-containing or vehicle pellets, with groups being randomized to myostatin or control antibody for 8 weeks. At …

Diagnosing Statistical Education Needs Of Health Science Learners, Amy S. Nowacki, Ann M. Brearley, Robert A. Oster, Emily Slade, Katrina L. Devick, Matthew J. Hayat, Sally W. Thurston

Biostatistics Faculty Publications

Many types of health science learners, including clinical and translational scientists, students, researchers, and clinicians, seek to increase their knowledge of biostatistics. These learners are heterogeneous in their field, career stage and career focus. Based on the collective experience of an expert panel with over 115 years teaching statistics to health science learners, we propose a framework for considering the needs of health science learners motivated by their career goals. This framework defines four types of health science learners seeking statistical training: (a) consumers, (b) “milestone makers”, (c) biomedical researchers with statistical support, and (d) biomedical researchers without statistical support. …

Quantitative Magnetic Resonance Imaging Responses In Head And Neck Cancer Patients Treated With Magnetic Resonance-Guided Hypofractionated Radiation Therapy, Ryan Bonate, Musaddiq J. Awan, Heather A. Himburg, Stuart Wong, Monica Shukla, Sergey Tarima, Joseph Zenga, Eric S. Paulson

Biostatistics Faculty Publications

Background and purpose: Quantitative MRI (qMRI) has been explored for detecting tumor changes during radiation therapy (RT) in head and neck squamous cell cancer (HNSCC). Clinical trials show prolonged survival with PD-1 targeted immune checkpoint inhibition. Hypofractionated radiation regimens are being studied to counteract radioresistant clonogen formation. This study aims to use daily qMRI monitoring in these therapies. The objective of this exploratory study was to investigate if qMRI can detect tumor microenvironment changes during hypofractionated RT in a phase I trial of Dose-Escalated Hypofractionated Adaptive Radiotherapy (DEHART). Materials and methods: Seventeen subjects with advanced HNSCC underwent MR-guided RT with …

Pecto-Intercostal Fascial Plane Block With Or Without Rectus Sheath Block In Cardiac Surgery, Anne L. Castro, Hemanckur Makker, Laura S. Gonzalez, Audrey Jensen, Sergey S. Tarima, Adam Pagryzinski, Rozalin Thapa, Ali Qureshi, Christopher Fadumiye, Krystal Weierstahl, Paul Pearson, Julie K. Freed

Biostatistics Faculty Publications

Background Median sternotomy and chest tube sites drive pain following cardiac surgery. Prior research has demonstrated that pecto-intercostal fascial plane blocks (PIFBs) reduce median sternotomy pain after cardiac surgery. Prior studies examining the addition of a rectus sheath block (RSB) to localize the insertion site of subxiphoid chest tubes have had mixed results. Methods In this single-center, randomized, double-blind, placebo-controlled trial, 62 patients undergoing cardiac surgery with median sternotomy and subxiphoid chest tubes were randomized to receive PIFB and RSB with local anesthetic versus PIFB with local anesthetic and RSB with saline placebo. The primary outcome was pain at rest …

The Association Between Four Neighborhood Disadvantage Indices And Child Chronic Health Classifications, Kahir Jawad, Yana B. Feygin, Michelle Stevenson, Bethany A. Wattles, Jennifer Porter, V. Faye Jones, Deborah Winders Davis

Biostatistics Faculty Publications

Background: Neighborhood advantage/disadvantage is a social determinant of health. We aimed to examine the distribution and associations between child chronic health conditions and four commonly used indices. Methods: Children with outpatient visits and valid addresses (n = 115,738) were included and outcomes were categorized as having no chronic disease (N-CD), non-complex chronic disease (NC-CD), and complex chronic disease (C-CD). Four measures of neighborhood characteristics (Child Opportunity Index, Area Deprivation Index, Neighborhood Disadvantage Index, Social Vulnerability Index were calculated from census data. Separate multinomial logistic regression models were used. Results: The indices’ scores were correlated (r = 0.80–0.92). Children in low …

Utilization And Outcomes Of Single-Troponin Discharge From The Emergency Department In A Low-Risk Population, Zhengqiu Zhou, Kory Heier, Jeffrey F. Spindel, Austin Harris, Emily Slade, Weston Mccowan, Dealla Samadi, Joshua Kim, James D. Moore, Seth T. Stearley, Vedant Gupta

Biostatistics Faculty Publications

Objectives: There is emerging data supporting rapid triage of low-risk chest pain patients to help facilitate Emergency Department (ED) throughput. We assessed an algorithm for accelerated rule-out of acute coronary syndrome in low-risk patients with an undetectable initial high sensitivity cardiac troponin (hs-cTn assays; Roche Diagnostics) in a real-world clinical setting. Methods: All adults presenting with chief complaint of non-traumatic chest pain to our tertiary care ED with HEART score ≤3 with at least one hs-cTn and EKG obtained were included in our study. Data and outcomes were compared three months before and after implementation of our updated Acute Chest …

The Inevitable Rise And Liberation Of Bipoc Community At Cal Poly Humboldt: A Historical Storytelling Timeline, Fernando Paz

Humboldt Journal of Social Relations

"The Historical Storytelling Timeline (HST) emerged as a central initiative in Cal Poly Humboldt's efforts to support and inform the Institutional Anti-Racism Call to Action Plan (IARCAP). Guided by the Office of Diversity, Equity, and Inclusion (ODEI), the HST not only chronicles the university's history of activism but also digitizes these efforts to ensure accessibility for future generations. This timeline is a commitment to honoring past struggles and successes..."

Echando Raíz In Humboldt County: Stories From Our Latine And Indigenous Immigrant Community, Andrea Delgado, Cinthya Ammerman Muñoz

Humboldt Journal of Social Relations

"Centro del Pueblo (CDP) is a local grassroots organization dedicated to empowering the undercounted and underserved Indigenous migrant population in Humboldt County and uplifting their cultural practices, ecological knowledges, and languages. In 2020, CDP established the Jardín Santuario (Sanctuary Garden)..."

Exploring Creative Processes In Elementary Art Education: Memory, Observation, And Imagination, Angela Steuer

Graduate Research Papers

This study explores the factors influencing idea generation and creativity in young students, focusing on 4th graders' engagement using comics as a motivational tool. It examines the roles of memory, observation, and imagination in shaping artistic choices, as well as the impact of teaching strategies, such as structured challenges and personal storytelling, in fostering creativity. This research offers insights into how tailored instructional practices and cognitive processes support the artistic development of elementary students, empowering them to generate original ideas and create meaningful artwork.

Intergenerational Arts In The Classroom: A Win-Win, Audrey Klunenberg

Graduate Research Papers

This paper suggests that intergenerational arts programs, particularly those conducted in public schools, can help participants build empathy, a sense of community and belonging. Evidence of these changes was collected through informal observations during three intergenerational art classes in a first grade classroom, as well as through discussions with participants before and after their participation in the intergenerational arts programming. Empathy and community can be built through carefully planned collaborative art-making opportunities and the effect can be evidenced in the forming of relationships, the absence of behavioral problems, and the building of the facilitator’s personal network. The paper concludes that …