Digital Commons Network^™

Validation Of Salivary Proteomic Biomarkers For Early Detection Of Oral Cancer In The Egyptian Population, Dalia Ghalwash, Ahmed M. Ammar, Ayman El-Gawish

Dentistry

Purpose: The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any poss associations with risk factors of oral cancer in an Egyptian population Methods: The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed. Results: Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased …

Synergistic Potential Of Ivermectin And Doxorubicin In Oral Squamous Cell Carcinoma: An In Vitro Investigation, Dalia Ghalwash, Shereen Nader, Rana Tantawy

Dentistry

Background Doxorubicin (DOX) is widely used in cancer therapy, but its role in oral squamous cell carcinoma (OSCC)is limited by resistance and dose-related toxicities. Ivermectin (IVM), an antiparasitic agent with emerging anticancer properties, may enhance DOX efficacy. This study evaluated the effects of IVM alone and in combination with DOX on OSCC cell lines.

Methods In vitro assays, including MTT viability, apoptosis (Annexin V/PI), cell cycle analysis, RT-qPCR of apoptotic, proliferative, and inflammatory markers, and oxidative stress assays, were performed on HN9 and HEp-2 OSCC cell lines, with OEC as control.

Results IVM reduced cancer cell viability in a dose-dependent …

Spatiotemporal Economic Impact Analysis Of The Taal Volcano Eruption Using Electricity Consumption And Nighttime Light Data, Ma Flordeliza P. Del Castillo, Toshio Fujimi, Hirokazu Tatano

SOSE Affiliate: Manila Observatory

Analyzing the spatiotemporal dimension of the economic impacts of disasters is critical for providing timely and proportionate support. However, traditional economic impact measures often lack spatiotemporal details. Hence, we estimated the daily electricity consumption (EC) loss using high-frequency EC data and analyzed temporal dimensions of the immediate impacts of Taal Volcano’s eruption on January 12, 2020. Subsequently, we computed the nighttime light (NTL) change using high-resolution NTL data to analyze the spatial distribution of these impacts. The temporal analysis revealed two EC loss peaks. The first peak coincided with the power outage and decreased energy demand, followed by a brief …

"I’Ll Wait Zero Seconds": Faculty Perspectives On Serials Access, Sharing, And Immediacy, Rachel Elizabeth Scott, Anne Shelley, Chad E. Buckley, Cassie Thayer-Styes, Julie A. Murphy

Faculty and Staff Publications – Milner Library

This study explores how faculty across disciplines access and share scholarly serial content and what expectations they have for immediacy. The authors conducted twenty-five in-depth, semi-structured interviews with faculty of various ranks representing all Illinois State University (ISU) colleges. The findings, presented in the words of participants and triangulated with data from local sources, suggest that faculty use a variety of context-specific mechanisms to access and share serial literature. Participants discuss how they use library services such as databases, subscriptions, interlibrary loan, and document delivery, coupled with academic social networks, disciplinary repositories, author websites, and other publicly available sources to …

Heritability And Shared Environmental Effects Of Brain Diseases In 12,040 Extended Families, Janna I R Dijkstra, Marc Hulsman, Lisa Waterink, Henne Holstege, Charlotte E Teunissen, Wouter F L Christiaansen, Bryan A De Jong, Peter Kochunov, Brian Donohue, Marissa D Zwan, Anouk Den Braber, Lisa Vermunt, Sven J Van Der Lee

Faculty, Staff and Student Publications

Brain diseases have complex patterns of genetic and environmental risk factors, and better understanding of these risks is required for more effective prevention strategies. Participants of the Dutch Brain Research Registry provided detailed information on family structure and occurrence of brain diseases. A total of 12,040 participants (73% female, aged 64.9 ± 11 years) provided information on 101,379 family members (53% female, aged 62 ± 25 years). We estimated heritability (h2) of the nine most common brain diseases using polygenic modeling in SOLAR and assessed variations in h2 through bootstrapping; Alzheimer’s disease (AD) (h2 = …

Book Review: Struggles For Reproductive Justice In The Era Of Anti-Genderism And Religious Fundamentalism, Ayushi Raghuwanshi

Journal of International Women's Studies

No abstract provided.

Book Review Essay: Reading The Witch Otherwise: Decolonial Reckonings And Epistemic Disobedience In The Witch Studies Reader, Moussa Pourya Asl

Journal of International Women's Studies

No abstract provided.

Film Review: Beta Mau Jumpa [Ambon: A Return To Peace], La Sugi

Journal of International Women's Studies

No abstract provided.

Washington’S Crime Free Rental Housing Programs: A Two-Tier Housing Regime, Eric Strain

Seattle Journal for Social Justice

No abstract provided.

Somewhere To Exist, Morgan Sandys

Seattle Journal for Social Justice

No abstract provided.

Tawny, Tyrannous Dr. Francia And Carlyle’S Confused South America, Marisa Palacios Knox

Literatures and Cultural Studies Faculty Publications

Scholars have highlighted Thomas Carlyle’s “Occasional Discourse on the Negro Question” (1849) as a point of no return for Carlyle’s descent into a full-throated advocacy of racism, imperialism, and proto-fascism. His 1843 article “Dr. Francia” on the late Paraguayan dictator has garnered much less critical attention than the provocative “Occasional Discourse,” but it simultaneously anticipates the latter essay and offers an alternative representation of Carlyle’s ideas—and Victorian ideas more generally— about shifting categories of race and imperialism before they congealed. Instead of positioning himself as the authoritative interpreter of Francia, Carlyle highlights his own uncertainty, taking as a central premise …

A Sequential Quadratic Programming Approach To Coupling‐Bounded Non‐Inertial Earthquake Cycle Kinematics With Distance‐Weighted Eigenmodes, Brendan J. Meade, John P. Loveless

Astronomy: Faculty Publications

Geologic and geodetic observations provide constraints on tectonic and earthquake cycle kinematics. Block models offer one approach to integrating the effects of plate rotations, elastic strain accumulation, applied basal displacements, internal block strain, and idealized pressure sources. Here, we describe the construction of block models where spatially variable slip rates are parameterized by distance‐weighted eigenmodes operating over meshes of triangular dislocation elements. This dimensionally reduced model is recast as a quadratic programming problem with upper and lower bounds on both geologic fault slip rates and spatially variable slip deficit rates. We propose iterating over successive quadratic programming estimates with evolving …

A Study Of Human Services In The Town Of Natick, Caitlin E. Coyle, Mary Krebs, Morgan Clark, Matt Frye

Center for Social and Demographic Research on Aging Publications

The Town of Natick has committed to engaging the community to guide efforts to update and modernize municipal policies, procedures, and programs such that they appropriately reflect the needs and interests of the community.

Between 2021 and 2022, the Community Services Department underwent some organizational restructuring, which included staffing changes and the inclusion of Recreation & Parks and the Sassamon Trace Golf Course as divisions within the department, which already included the Council on Aging & Human Services, Veterans Services, and the Natick Community Organic Farm4. The Community Services Department is “charged with responding to the needs, interests and quality …

The Formal Garden And Fruit Wall 2019, 2021, And 2022 Field Seasons Gore Place, Waltham, Ma, Christa M. Beranek, John M. Steinberg

Andrew Fiske Memorial Center for Archaeological Research Publications

The Fiske Center for Archaeological Research at UMass Boston engaged in a multi-season examination of the formal landscape north of the mansion house at Gore Place in Waltham and Watertown, Massachusetts. The archeological work consisted of a geophysical survey of the whole area in the fall of 2019 and excavation in the summer of 2021 and 2022 focusing on the southeast corner of the formal garden and the eastern wing of the fruit wall. Excavation units covered just over 63 sq m. The excavations identified large areas where Gore period features were preserved. In the southeast corner most units were …

How Inclusive Are Degree Programs In Operations Research And Analytics In The U.S.?, Michael P. Johnson Jr., Tayo Fabusuyi, Elham Hesari, Salina Chu

Public Policy and Public Affairs Faculty Publication Series

Academic programs in colleges and universities in the United States have increasingly embraced principles of equity and inclusion to support student success and diversity within professions. Innovations in diversity, equity, and inclusion (DEI) in university programs require baseline data on students, faculty and administrators, curricula, and programmatic support. A review of data shows that underrepresented groups in the US workforce have limited visibility in operations research and analytics. A review of DEI-related research reveals some relevant insights including a gap in studies specific to operations research and analytics.

To provide evidence in support of DEI initiatives in OR/analytics, we describe …

Archaeological Fieldwork In The El Rancho De Las Golondrinas Museum Core (La 127375), La Cienega, New Mexico: An Interim Report, Heather Trigg, Sara Jaramillo, Tara Noel, Iris Glinski

Andrew Fiske Memorial Center for Archaeological Research Publications

No abstract provided.

100 Years Of The Federal Arbitration Act, Paul Bland, John H. Chun, Linda A. Klein, Pamela K. Bookman

Faculty Scholarship

No abstract provided.

Reimagining Main Street: Themed Experience Design As A Tool For Small Town Revitalization, Carrie L. Schweiger

Graduate Thesis and Dissertation post-2024

The idea of the American main street is deeply embedded in popular culture, often seen through layers of nostalgia that can obscure the real-world conditions of today. While an idealized nostalgia may benefit some towns, decades of change have left many struggling to fit the mold. This thesis explores how core principles of themed experience design can be integrated into existing American main streets, reimagining the way residents interact and identify with these spaces.

Examining historical upheavals alongside decades of media portrayals brings insight into the different stories embedded in America’s small towns, many of which remain focused on the …

Acute Strength Training, Not Menstrual Cycle Phase, Increases Lipid Oxidation Rates Following Exercise In Well-Trained, Eumenorrheic Females., Alyssa L. Parten, Abbie E. Smith-Ryan, Eric K. O'Neal, T Scott Lyons, Hunter S. Waldman

Kinesiology

Previous research supports the role of 17-β-estradiol (E₂) and progesterone (P₄) in altering lipid oxidation (LOx) rates during aerobic exercise, but it has yet to be determined if LOx is altered between menstrual cycle (MC) phases following strength training (STR). This study examined post-exercise LOx rates in eumenorrheic females, following a bout of STR during the early-follicular phase (EFP) and mid-luteal phase (MLP). Twenty-two (age: 25.1 ± 5.7, BMI: 24.5 ± 2.7) well-trained females completed a repetition maximum (RM) test for the back squat, bench press, and deadlift. Five sets of 3 repetitions at 80-85% 1RM …

Lost Things, Aloysius Devine

Graduate Thesis and Dissertation post-2024

Lost Things is a novella that explores sexuality, family, and mental illness. When Pearl drops out of college following a crisis in mental health, she returns to Sunnyside, Florida, where she does not belong. Pearl’s queerness and inability to meet her mother’s harsh expectations render her an outsider in her own home. However, Pearl finds solace and companionship in Saint Anthony, a goldfish her little sister won at the school fair. Pearl and Saint Anthony devolve into mutual obsession: Pearl, with the beached blue whale that washes up a mile from her home, and Saint Anthony with the ocean. Pearl’s …

Child Abuse In The Name Of Free Speech: Against Protecting Conversion Therapy As Free Speech, Siobhán Nolan

Seattle Journal for Social Justice

No abstract provided.

Innocence Loan Funds: A New Approach To Exonoree Support, Timothy Fisher

Seattle Journal for Social Justice

Wrongfully convicted persons face daunting life pressures when released after years of confinement. A patchwork of programs exist around the country to provide support, but the financial assistance that exonerees need is sparce. Some exonerees turn to finance companies, whose loans carry high interest rates. A better solution is an innocence fund: a non-recourse loan fund, repaid out of exoneree compensation or litigation recovery. This article details the structure of one such fund, which has made hundreds of thousands of dollars in loans with zero defaults. The article provides a guide to jurisdictions around the country on how to establish …

Front Matters, Sjsj 2025

Seattle Journal for Social Justice

No abstract provided.

We The Queers, Merrick Sloane

Seattle Journal for Social Justice

No abstract provided.

Youth Voice: Civic Engagement, Rights, And The Wellbeing Of Children, Jonathan Todres, Folashade Epebinu, Chelsea Osei, Gabrielle Listana

Seattle Journal for Social Justice

No abstract provided.

Reunion With A Peer Partner Reduces Pvn Oxytocin Neuron Immunoreactivity In Socially Selective Voles, Nastacia L. Goodwin, Al M. Licata, Kelley C. Power, Kara M. Reitz, Yasmin Kamal, Annaliese K. Beery

Psychology: Faculty Publications

Friendships—i.e. selective peer relationships—are an important aspect of human behavior, but are rare in rodent species. Meadow voles are seasonally social rodents that form non-reproductive social groups in winter/short day lengths that are selective in nature. Across rodents, oxytocin neurons in the paraventricular nucleus (PVN) of the hypothalamus are typically active during socially salient events, including interaction with novel individuals as well as social separation. To assess whether familiar and novel peer interactions produce different patterns of immunolabeling in a species that forms bonds with familiar individuals, we measured oxytocin neuron immunoreactivity and colabeling with the immediate early gene product …

The Contributions Of Language And Inhibitory Control To False Belief Reasoning Over Time, Jill De Villiers, Peter A. De Villiers

Psychology: Faculty Publications

Introduction: The role of language in false belief reasoning has been much debated for twenty-five years or more, especially the relative contributions of general language development, complement syntax, vocabulary, and executive function. However, the empirical studies so far have fallen short, in that they generally have too few participants for adequate statistical modeling; they do not include control variables; or they are cross-sectional rather than longitudinal, making inferences about causal direction much more tenuous.

Methods: The present study considers the role of these different variables in the development of false belief reasoning over several months of testing, with 258 children …

Investigating The Extent To Which Diet-Induced Obesity Alters Gene Expression In Hematopoietic Stem And Progenitor Cells Following Influenza Immunization In Mice, Chaitanya Lahari Chowdary Pathipati

Theses, Dissertations and Capstones

Vaccines are a vital tool in preventing diseases, but their effectiveness varies depending on factors like diet and body weight. Obese individuals often experience reduced vaccine protection, as seen with influenza vaccines, where they have twice the risk of getting the flu compared to healthy-weight individuals after vaccination. This study aims to understand why obesity weakens vaccine effectiveness, focusing on the role of blood-forming stem cells in the bone marrow, known as hematopoietic stem and progenitor cells (HSPCs). These cells are crucial for producing immune cells that defend the body against infections. Previous research has shown that diet-induced obesity alters …

Magnetic And Ph-Sensitive Dual Actuation Of Biohybrid Microswimmer Of Targeted Drug Release Suitable For Cancer Cell Microenvironment, Richa Chaturvedi, Yumin Kang, Yunji Eom, Sri Ramulu Torati, Cheolgi Kim

Center for Bioelectronics Publications

The chemotherapeutic agents most frequently used in cancer treatment often have limited effectiveness because of their low specificity for tumors and poor therapeutic performance. In addition to the aforementioned therapeutic challenges the drug delivery carriers conjugated with the drug encounter early detection and elimination from the immune system before arriving at the affected area continues to be a significant research focus among researchers. To address this prevalent issue, an effective approach has been developed that leverages the physiological differences between normal and tumor tissue to enhance the efficacy of anticancer drugs. This drug delivery system is designed based on pH-sensitive …

Cost-Effective Hierarchical Cobalt Nanostructured Laser-Induced Graphene For Enhanced Uric Acid Detection, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

This study presents an innovative, cost-effective strategy to develop a flexible, enzyme-free biosensor for the sensitive detection of uric acid (UA). Utilizing electrochemically modified cobalt nanostructured on laser-induced graphene electrodes (CoNCs/LIG), this approach surpasses traditional noble metal-based electrocatalysts in sensitivity and affordability. The one-step electrochemical modification method is efficient and straightforward, enabling the uniform deposition of hierarchical flower-like cobalt nanostructures. These structures synergistically enhance the performance of the LIG, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM^-¹ cm^-² and a low detection limit of 3.66 µM for UA. …