Digital Commons Network^™

Social, Racial, And Economic Disparities Affecting Outcomes Of Hypertensive Adolescents, Kanya Singhapakdi, Amelia Haydel, Marla Johnston, Shengping Yang, Tamara Bradford, Dedrick Moulton, Thomas R. Kimball

School of Medicine Faculty Publications

Essential hypertension is one of the most common conditions managed in pediatric cardiology and can result in lasting deleterious effects on the cardiovascular system. Pediatric hypertension is so prevalent in the United States that it is often referred to as a public health challenge. Social determinants of health (SDH) are the cultural, economic, educational, healthcare accessibility, and political influences in the environment in which an individual is born or lives, all of which can affect that individual's overall health. This study investigated the impact of social determinants such as rurality, food insecurity, transportation challenges, minority status, income, and race on …

The Caitlin Clark Effect: Illuminating Women’S Sport History, Shelley Lucas

International Journal of Physical Activity and Health

The Caitlin Clark Effect is a term that describes the impact of the University of Iowa basketball player on the popularity of women’s basketball, which occurred in conjunction with Clark’s record-breaking performances in 2023 and 2024, as well as the Iowa team’s successes in the NCAA championship tournament. While the Caitlin Clark Effect is associated with intense media attention, ticket sales, and viewership, it also illuminates significant and lesser-known aspects of women’s sport history, specifically media coverage, the Association of Intercollegiate Athletics for Women (AIAW), and the state of Iowa’s unique basketball heritage and ‘6-on-6’ basketball rules. The purpose of …

Benefits, Challenges, And Strategies For Increasing Women Coaches In Elite Sport: The Trail To Gold (T2g) Initiative In U.S. Cross-Country Skiing, Anika Anna Angriman, Lynda B. Ransdell, Shelley Lucas, Nicole Lavoi

International Journal of Physical Activity and Health

Despite tremendous growth in sport participation of girls and women following Title IX in 1972, women’s participation as sport coaches did not follow the same trajectory. In fact, women remain significantly underrepresented in sport coaching. Research highlights ongoing barriers within the sport industry's patriarchal structure, and although strategies have been proposed to improve women’s representation, the lack of progress over the past two decades indicates limited effectiveness. A better approach is essential to address this issue across individual, interpersonal, organizational, and societal levels. The purpose of this study is to interview participants within the U.S. cross-country skiing program, Trail to …

Improper Fitting Personal Protective Clothing And Subsequent Countermeasures For Physical Conditioning In Female Firefighters: A Narrative Review, Katie Sell, Mark Abel, J. Jay Dawes, Megan Thompson, Annette Zapp, Ofra Pottorf, Lilly Bernardi, James Prendergast

International Journal of Physical Activity and Health

The purpose of this paper was to 1) use an explorative literature overview to identify issues related to ill-fitting clothing and occupational gear for female firefighters, and 2) use an inductive approach to develop generalizable recommendations for exercise professionals to utilize by identifying significant themes in published peer reviewed articles related to movement and injury risk. Research, including both qualitative and quantitative approaches, has shown that the majority of current personal protective clothing (PPC) and operational gear was developed to fit a limited array of male physiques. Consequently, the improper fit of PPC and gear has presented numerous concerns that, …

Impact Of A Light Volleyball Intervention Among Older Chinese Adult Women, Ka-Man Carman Leung, Paul Lee, Wing Sze Alice Lai, Yanan Zhao, Lynda Ransdell

International Journal of Physical Activity and Health

Modified sports offer a strategic approach to promoting health in older adults. Light volleyball, which uses a larger, lighter ball than traditional volleyball, is more accessible for this population. This study investigated the effects of a 16-week light volleyball program on the functional fitness of older adults in Hong Kong. A total of 275 participants aged 60 years or older were recruited and randomly assigned to three groups: a light volleyball intervention group, a Tai Chi group, and a control group. Functional fitness was assessed at the pretest, posttest, and 6-month follow-up. Results revealed that the light volleyball group exhibited …

Prevalence Of Autoimmune Diseases In Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network Of Health Care Organizations, Pushti Khandwala, Devashish Desai, Arthur Lau

Einstein Health Papers

OBJECTIVE: Evaluate prevalence of new onset autoimmune conditions (ACs) after commencement of immune checkpoint inhibitors (ICIs).

METHODS: This retrospective observational study was done using TriNetX. Patients with neoplasm for which ICIs were approved were stratified into two groups based on ICI use. Multivariate Cox proportional hazard models and Kaplan Meier method were used to assess risk of developing ACs among the groups. Subgroup analysis was done to evaluate risk of ACs in patients receiving cytotoxic T-lymphocyte-associated protein 4 inhibitor (CTLA4i) versus program cell death protein 1 inhibitor (PD1i) and program death ligand 1 inhibitor (PDL1i) inhibitors and combination treatment (CT) …

Use Of Multi-Modal Non-Contrast Mri To Predict Functional Outcomes After Stroke: A Study Using Dp-Pcasl, Dti, Noddi, And Map Mri, Julia Diamandi, Christian Raimondo, Keenan Piper, Joanna Roy, Stephanie Serva, Mahdi Alizadeh, Adam Flanders, Stavropoula Tjoumakaris, Michael Gooch, Pascal Jabbour, Robert Rosenwasswer, Nikolaos Mouchtouris

Department of Neurosurgery Faculty Papers

PURPOSE: This study aims to assess whether water exchange rate (k_w), a surrogate for blood-brain barrier (BBB) permeability, is associated with functional outcomes in patients with acute ischemic stroke (AIS).

METHODS: We studied 22 AIS patients enrolled from 1/2022 to 4/2024 who underwent multi-modal non-contrast imaging on a 3.0-Tesla scanner, including DP-pCASL, DTI, NODDI and MAP imaging. For each parametric map, the intensity and standard deviation (SD) were calculated for the infarcted region. The diffusion maps included were b0, Fractional Anisotropy (FA), Mean Diffusivity (MD), Intra-cellular Volume Fraction (ICVF), Free Water Fraction (FWF), and Orientation Dispersion Index (ODI), …

Single-Chain Variable Fragments: Targeting Snake Venom Phospholipase A2 And Serine Protease, Ying Jia, Ariane Garcia, Elizabeth Reyes

School of Integrative Biological & Chemical Sciences Faculty Publications

Snakebite is a critical global public health issue, causing substantial mortality and morbidity, particularly in tropical and subtropical regions. The development of innovative antivenoms targeting snake venom toxins is therefore of paramount importance. In this study, we adopted an epitope-directed approach to design three degenerate 15-mer peptides based on amino acid sequence alignments of snake venom phospholipase A2s (PLA2s) and snake venom serine proteases (SVSPs) from snake (Crotalus atrox). By leveraging their immunogenic and inhibitory profiles, these peptides were specifically designed to target the Asp49 and Lys49 variants of PLA2 and SVSP toxins. Groups of five mice were immunized with …

As-988-25 Resolution In Support Of Cal Poly's Transgender And Gender Non-Conforming Community, Academic Senate

Academic Senate Resolutions

Resolves that the Cal Poly Academic Senate unequivocally affirms its support for the rights, safety, and well-being of members of the Cal Poly community who identify as transgender, gender non-conforming, or any other identity encompassed within the LGBTQIA+ community; and it further resolves that the Academic Senate supports members of the Cal Poly community who identify as transgender, gender non-conforming, or any other identity encompassed within the LGBTQIA+ community and encourages the administration to continue implementing and expanding initiatives that provide education and training on gender inclusivity for all students, faculty, and staff; ensure access to gender-inclusive facilities, including restrooms …

The Perspectives Of African American Parents’ Decisions To Homeschool Children With Autism In New Jersey, Shannalee Stephenson

Walden Dissertations and Doctoral Studies

New Jersey is an autism epicenter and may indicate future trends in the United States. The population of American families opting to homeschool is growing, especially among African-American families in New Jersey. The purpose of this narrative inquiry study was to examine the perspectives of African American parents’ decisions to homeschool their children with autism in New Jersey through storytelling. The conceptual framework used was the model of parental involvement developed by Hoover-Dempsey and Sandler. Semi-structured interviews were conducted with 12 homeschooling African-American parents using a basic qualitative approach. The results were organized into five themes. One theme was the …

Central Line Associated Bloodstream Infection Prevention In Medical Intensive Care Unit, Linet Angir

Walden Dissertations and Doctoral Studies

. The doctoral project was a collaborative endeavor focused on central line dressing sites at a state university hospital in the northeastern United States. The aim was to reduce the current central line-associated infections (CLABSIs) rate. Through audits, it was discovered that most central line dressings needed to be completely sealed, some required insertion site clipping to ensure a complete seal, and some dressings were saturated. To uphold a commitment to quality care, clinical excellence, patient care, and superior outcomes, the Doctor of Nursing Practice (DNP) project recognized the importance of implementing the recommendations to reduce CLABSIs by maintaining central …

Fsec Meeting Minutes January 24, 2025, University Of Rhode Island Faculty Senate

Faculty Senate Executive Committee Minutes

No abstract provided.

Co-Option Of Mitochondrial Nucleic Acid-Sensing Pathways By Hsv-1 Ul12.5 For Reactivation From Latent Infection, Patryk A. Krakowiak, Matthew E. Flores, Sean R. Cuddy, Abigail L. Whitford, Sara A. Dochnal, Aleksandra Babnis, Tsuyoshi Miyake, Marco Tigano, Daniel A. Engel, Anna R. Cliffe

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus-1 (HSV-1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune-sensing pathways and reduces productive replication in nonneuronal cells. HSV-1 establishes latency in neurons and can reactivate to cause disease. We found that UL12.5 is required for HSV-1 reactivation in neurons and acts to directly promote viral lytic gene expression during initial exit from latency. Further, the direct activation of innate immune-sensing pathways triggered …

Adverse Side Effects Of Hemodialysis In Patients With End-Stage Chronic Renal Disease At Kassala Dialysis Center, Sudan, Muzamil Ahmed, Mustafa Khairelseed, Muzdlefa Ahmed, Mutaz Mohammed, Mutaz Omara

Iraqi National Journal of Medicine

Background: Hemodialysis is a treatment for advanced renal failure; however, various complications can arise following the procedure. Aim: This study aimed to investigate the incidence of adverse side effects during hemodialysis in patients with chronic renal failure. Methods: This descriptive hospital-based study was conducted on 105 patients treated with hemodialysis between November 2020 and January 2021 at the Kassala Dialysis Center in Kassala City, Kassala State, Sudan. Data were collected through interviews using a questionnaire designed to address the research questions. The data were analyzed using the software Statistical Package for the Social Sciences version 16. Results: The findings indicated …

Case Report: A Durable Response To Anastrozole Re-Challenge With Everolimus In A Patient With Advanced-Stage Estrogen Receptor-Positive Breast Cancer, Vincent Emma P Weiss

Iraqi National Journal of Medicine

Estrogen receptor-positive breast cancer is a heterogeneous disease characterized by its dependence on estrogen for growth and progression. Although hormonal therapy remains the cornerstone of treatment, many patients eventually develop resistance, leading to recurrence and disease progression. This case report describes a durable response to a rechallenge with Anastrozole (Arimidex) in combination with Everolimus (Afinitor), an mTOR inhibitor, in a patient with advanced (stage IV) ER+ metastatic breast cancer.

The Pierre Auger Observatory Open Data, M. Zavrtanik, D. Zavrtanik, E. Zas, O. Zapparrata, A. Yushkov, B. Yue, B. Fick, K. Nguyen, D. Nitz, Et Al.

Michigan Tech Publications

The Pierre Auger Collaboration has embraced the concept of open access to their research data since its foundation, with the aim of giving access to the widest possible community. A gradual process of release began as early as 2007 when 1% of the cosmic-ray data was made public, along with 100% of the space-weather information. In February 2021, a portal was released containing 10% of cosmic-ray data collected by the Pierre Auger Observatory from 2004 to 2018, during the first phase of operation of the Observatory. The Open Data Portal includes detailed documentation about the detection and reconstruction procedures, analysis …

Transforming Diagnosis Through Artificial Intelligence

Faculty, Staff and Students Publications

Artificial intelligence (AI) is increasingly permeating the fabric of medicine, but getting full benefits will likely require fundamental changes in practice. Accepting this will be challenging for many clinicians. However, it may be necessary to ensure that AI’s ambitious promises translate into real-life improvement.

A Randomized, Placebo-Controlled, Cross-Over Trial Of Ketamine In Rett Syndrome, Elizabeth Berry-Kravis, Tim A Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L Carpenter, Eric D Marsh, Jana Von Hehn

Faculty, Staff and Students Publications

BACKGROUND: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy.

DESIGN: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy.

METHODS: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Multicolor Surface Protein Detection And Cancer Classification Using Plasmonic/Magnetic Raman Nanotags And Machine Learning Algorithm, Alberto Luis Rodriguez-Nieves

Electronic Theses and Dissertations Archive

Gold and magnetic-based hybrid nanoparticles have demonstrated their usefulness in the biomedical field due to their ability to multitask including combined optical and magnetic properties, ease of surface modification, biocompatibility, and synthesis versatility. These physical and chemical properties have allowed the development of new applications in the medical field, such as therapeutic and detection of biological markers. Our research has focused on the development of gold and magnetic-based hybrid nanoparticles for early detection, quantification, and classification of circulating biomarkers. Circulating markers are composed of nucleic acids (DNA and RNA), circulating tumor cells, extracellular vesicles, and proteins. The clinical significance of …

The Influence Student Behavior Is Having In Today's Schools, Kelsey L. Aureli

Electronic Theses and Dissertations Archive

This study examined teachers’ perceptions and experiences regarding the interrelationships between behavior policy, student behavior, and autonomy-supportive behavior. It approximated the realities experienced by teachers to gain a deeper understanding of the challenges they encountered in implementing behavior policies and fostering autonomy-supportive behavior. While attrition, shortage, and dissatisfaction were not the primary focus, they significantly influenced the teacher participants based on their experiences with high teacher turnover in their schools. I collected qualitative through semi-structured interviews to explore teachers’ realities, using six participants from Memphis Shelby County Schools. By utilizing conflict theory and the ambiguity-conflict matrix adapted from Matland (1997), …

Some Contradictions Of The Welfare State: Revisited, Chris O'Ralaigh

Research Outputs: 2025-Present

It is now 40 years since the publication of Claus Offe's classical paper, Some Contradictions of the Modern Welfare State. Much change has occurred to the form and content of welfare states over the intervening years, yet in addition to change, continuities are very much evident, and it is this constellation of developments – alongside anniversarial convenience – which has motivated a re-examination of Offe's seminal work on the contradictions of welfare states. This anniversary article re-introduces and provides a critique of the original paper before moving on to a historical comparison of the major political economic and societal differences …

Incorporating Visual Information Into Natural Language Processing, Maxwell Mbabilla Aladago

Dartmouth College Ph.D Dissertations

Natural language describes entities in the world, some real and some abstract. It is also common practice to complement human learning of natural language with visual cues. This is evident in the heavily graphical nature of children’s literature which underscores the importance of visual cues in language acquisition. Similarly, the notion of “visual learners” is well recognized, reflecting the understanding that visual signals such as illustrations, gestures, and depictions effectively supplement language. In machine learning, two primary paradigms have emerged for training systems involving natural language. The first paradigm encompasses setups where pre-training and downstream tasks are exclusively in natural …

Draft Final Phase I Pre-Design Investigation Evaluation Report Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Exhibit 2 “Basement Iswp” 604 S. Clark St. Butte, Mt 59701 January 24, 2025 Database Residential Identifier: R-01537, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) - Cccs Gym Annex, Christopher Berg, Thomas J. Beckman

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Perspectives Of African American Parents’ Decisions To Homeschool Children With Autism In New Jersey, Shannalee Stephenson

Walden Dissertations and Doctoral Studies

New Jersey is an autism epicenter and may indicate future trends in the United States. The population of American families opting to homeschool is growing, especially among African-American families in New Jersey. The purpose of this narrative inquiry study was to examine the perspectives of African American parents’ decisions to homeschool their children with autism in New Jersey through storytelling. The conceptual framework used was the model of parental involvement developed by Hoover-Dempsey and Sandler. Semi-structured interviews were conducted with 12 homeschooling African-American parents using a basic qualitative approach. The results were organized into five themes. One theme was the …

Female Runners’ Perspectives Of Coping With Relative Energy Deficiency In Sports (Red-S) Symptoms Through Instructor-Led Yoga, April Rae Gunnoe

Walden Dissertations and Doctoral Studies

Relative energy deficiency in sports (RED-S) impacts the physical, emotional, and psychological health of adult female runners. Previous RED-S inquiry has focused on identification and evaluation of symptoms, and although researchers have investigated ways in which yoga affects adult female runner’s physical and mental health, understanding about the potential impact of instructor-led yoga practice in the treatment and management of RED-S symptoms is limited. The purpose of this basic qualitative inquiry was to investigate the lived experiences of adult female runners practicing instructor-led yoga to cope with RED-S symptoms, using the health belief model as a framework. Eight volunteers shared …

Experiences Of Law Enforcement In Workplace Violence Threat Investigations, Heather Folkestad

Walden Dissertations and Doctoral Studies

A significant social problem affecting law enforcement investigations into workplace violence is the lack of threat assessments and threat management programs performed in workplace investigations. Collaboration with law enforcement early in workplace violence investigations has significant benefits within the corporate sector. The purpose of this basic qualitative study was to examine the experiences of law enforcement officers/agents involved in targeted violence workplace investigations. Areas of focus were the collective perspectives of participants regarding the use of threat assessments, inclusion of law enforcement, and the barriers to an effective investigation within the workplace and by community law enforcement. This study utilized …

Central Line Associated Bloodstream Infection Prevention In Medical Intensive Care Unit, Linet Angir

Walden Dissertations and Doctoral Studies

. The doctoral project was a collaborative endeavor focused on central line dressing sites at a state university hospital in the northeastern United States. The aim was to reduce the current central line-associated infections (CLABSIs) rate. Through audits, it was discovered that most central line dressings needed to be completely sealed, some required insertion site clipping to ensure a complete seal, and some dressings were saturated. To uphold a commitment to quality care, clinical excellence, patient care, and superior outcomes, the Doctor of Nursing Practice (DNP) project recognized the importance of implementing the recommendations to reduce CLABSIs by maintaining central …