Digital Commons Network^™

The Role Of Confined Hydration And Water Reorganization In Molecular Binding, Joe Z. Wu

Dissertations, Theses, and Capstone Projects

An important factor in guiding the development of drug discovery efforts is the comprehensive assessment of a ligand or drug’s ability to bind its receptor. The metric used to measure this interaction strength is by calculating the binding free energy (BFE). To achieve this accurately, we combine two concepts: (1) Grid Inhomogeneous Solvation Theory (GIST) returns the local water thermodynamic and structural contributions to free energy; and the (2) Alchemical Transfer Method (ATM) obtains the absolute (ABFE) and relative binding free energy (RBFE) estimates between ligand pairs. In this work, we employ Alchemical Water-Transfer to tether bridging water(s) during the …

Guaqueras And Campesinas In Western Boyacá, Colombia, María F. Buitrago

Dissertations, Theses, and Capstone Projects

Guaqueras and Campesinas in Western Boyacá (https://mariabuitsan.github.io/guaqueras-ycampesinas/) is a digital memory project chronicling the lives and labors of women residing in the emerald-producing municipalities of Colombia. The project explores women’s remarkable resilience amidst a historically extractive and patriarchal emerald economy by co-creating an online collection enriched with various sources such as interviews, photos of artifacts, and audio from fieldwork. The collection uses Dédalo, a free and open-source Cultural Heritage and Management System, to store, digitize, and index all the unedited material and presents a selection of these resources through a static website. The collection intends to illuminate and honor the …

Mad At The System: The Mental Health Act Uk: Power And Control Of Racialized Women, Maithreyi Rajeshkumar

Dissertations, Theses, and Capstone Projects

Whilst experiences of madness are multiple, fluid and multi-dimensional across spiritual and collective dimensions globally, the categorization and regulation of ‘madness’ have direct foundations in European colonial-capitalist-patriarchal frameworks, policies and systems. This work focuses on the institutions and structures of power, turning UK legislation and those who are trying to reform or change it, into objects of study. A particular piece of United Kingdom legislation is the primary case study for this work – the Mental Health Act 1983 which covers the rights, assessment and treatment of people diagnosed with a ‘mental disorder’. Women, who are detained under this Act …

Silver-Alloyed Cigs Thin-Film Solar Cells On Flexible Stainless-Steel Substrate, Zhi Huang

Dissertations, Theses, and Capstone Projects

Our dissertation demonstrates the optimization of ACIGS (Ag-Cu-In-Ga-Se) thin-film solar cells, achieving an efficiency of 20.4% through the combined effects of silver incorporation and alkali metal post-deposition treatment (PDT). The incorporation of 2.8% Ag into the CIGS lattice enhanced crystal quality, reduced disorder, and widened the bandgap by 0.103 eV, as evidenced by a significant reduction in Urbach energy. These improvements resulted in stronger light absorption, increased carrier generation, and enhanced photovoltaic parameters, including a short-circuit current density Jsc of 35.31 mA/cm², an open-circuit voltage Voc of 0.74 V, and a fill factor (FF) of 75.8%. PDT using rubidium fluoride …

China And Russia In Africa: The Case Of Togo, Eli J. Messanh

Dissertations, Theses, and Capstone Projects

This thesis examines the impacts of China and Russia’s influence in Africa and focuses on the case of Togo, looking into how the increase in China and Russia’s presence on the continent affects the latter, the similarities and differences of their engagements, and what Africans as well as Togolese think of the proliferation of China and Russia’s influence in their countries. Using a mixed-methods approach with discussions and in-depth literature reviews, the research concludes that China and Russia’s relations vis à vis African countries produce both positive and negative effects, however, the negative effects outweigh the positive. It is therefore …

Multi-Document Graph Visualizer: Bridging Computational Text Analysis And Interactive Visualization For Large-Scale Text Corpora, Atilio Barreda Ii

Dissertations, Theses, and Capstone Projects

This thesis introduces the Multi-Document Graph Visualizer (MDGV), a tool designed to analyze and visualize relationships within large-scale text corpora, addressing a critical gap in computational text analysis. By synthesizing state-of-the-art natural language processing (NLP) techniques with advanced interactive data visualization, MDGV empowers researchers across disciplines—including the sciences, social sciences, and humanities—to uncover latent connections, relationships, and patterns in vast and complex document collections. Importantly, MDGV requires limited technical expertise from its users, making it accessible to a broader audience of researchers and practitioners. This approach draws on Haraway's concept of situated knowledges, which emphasizes interpretability and engagement in …

Evidence For Alpha-Synuclein Aggregation In Older Individuals With Hyposmia: A Cross-Sectional Study, Danna Jennings, John Seibyl, Matthew Stern, Claudio Soto, Andrew Siderowf

Faculty, Staff and Student Publications

Background: Synuclein pathology in neurodegenerative diseases, such as Parkinson's disease (PD) and Dementia with Lewy bodies (DLB), begins years before motor or cognitive symptoms arise. Alpha-Synuclein seed amplification assays (α-syn SAA) may detect aggregated synuclein before symptoms occur.

Methods: Data from the Parkinson Associated Risk Syndrome Study (PARS) have shown that individuals with hyposmia, without motor or cognitive symptoms, are enriched for dopamine transporter imaging (DAT) deficit and are at high risk to develop clinical parkinsonism or related synucleinopathies. α-syn aggregates in CSF were measured in 100 PARS participants using α-syn SAA.

Findings: CSF α-syn SAA was positive in 48% …

Connecting Developed Pressure – Preload Relationship In Ex-Vivo Beating Heart With Cellular Sarcomere Length – Tension Relationship, Lei Fan, Vahid Ziaei-Rad, Jason Bazil, Lik Chuan Lee

Biomedical Engineering Faculty Research and Publications

The heart’s developed pressure (DP) in Langendorff heart experiments increases with preload via the Frank-Starling mechanism up to a critical transition point at which DP starts to decrease with preload. A similar behavior is found at the cellular level, where the tension developed by skinned cardiac fibers or myocytes in isometric tension test increases with sarcomere length up to a transition point beyond which, the tension decreases. This cellular-level behavior is termed myofilament length dependent activation. While these two behaviors are similar, they occur at vastly different scales. Specifically, the DP – preload and sarcomere length – tension relationships occur, …

Fast Or Slow? A Meta-Analysis On The Performance Implications Of Decision, Implementation, And Response Speed, Kalin Kolev, Bernadine J. Dykes, Saehee Kang, Margaret Hughes-Morgan, Walter J. Ferrier

Management Faculty Research and Publications

Speed across various organizational processes, such as decision-making, executing operational activities, and responding to competitive challenges, represents an essential component of firms’ ability to achieve a competitive advantage. However, a theoretical and empirical consensus has yet to form whether decision speed (DS), implementation speed (IS), and response speed (RS) are beneficial or detrimental to firm performance. To help reconcile these inconclusive findings, we meta-analyze 127 studies (representing 239 effect sizes) and report overall direct effects for DS (0.21), IS (0.22), and RS (0.10) on firm performance. In addition, we examine contingencies which reveal that the performance consequences of DS, IS, …

20250201: Football Vhs Collection, 1992-2009, Athletics

Guides to University Archives

These items include materials from the Department of Athletics at Marshall University from 1992-2009. Items were received in 2025. This is not the only collection of materials for Marshall University Football, but this specific collection includes coverage of the football season, including but not limited to games during the date range period. Please download the finding aid for a full list of contents in this specific collection.

From Football To Construction: Transferring Leadership Competencies For The Era Of Construction 4.0, Payson W. Campisano

Construction Management

This study aims to explore the intersection of leadership competencies developed through football and their applicability to the construction industry, with a focus placed on the emerging leadership needs in Construction 4.0. Drawing on insights from interviews with current and former student-athletes who study or studied construction management at the California Polytechnic State University in San Luis Obispo, the research highlights the transferability of key leadership qualities from football, such as resilience, teamwork, and critical thinking, to the cognitive, interpersonal, business, and strategic domains of leadership within construction management. Building on the work of Yang, Sunindijo, and Wang (2020), who …

Mustang Living: A Guide To Student Housing, Anna L. Casper

Journalism

It is not an easy transition for college students to go from living in a place they have called home, to struggling to secure a reliable and affordable home as a college student who moved away from home for the first time. This significant milestone should be a task that is rewarding and exciting, rather than life-altering and stressful. When envisioning a way to heal the chaos of house searching in San Luis Obispo, "Mustang Living" would be a dedicated section of Mustang News, available in both print and digital formats, designed to serve as a comprehensive resource for students …

Reperfused Myocardial Infarction: The Road To Ccs Classification Of Acute Mi And Beyond., Rohan Dharmakumar, Robert A Kloner, Michael Fishbein, Gerd Heusch, Keyur P Vora, Robert Gropler, Timothy Henry, Fai Shing-Chan, Dhirendra Singh, Nithya Jambunathan, Ramesh Subramanian, Rolf P Kreutz, Grant W Reed, Richard J Kovacs, Edward Fry, Ankur Kalra, Andreas Kumar, Subha V Raman

Heart and Vascular Articles

The Canadian Cardiovascular Society recently put forth a new classification of acute reperfused myocardial infarction (MI) based on stages of myocardial injury. Backed by more than 5 decades of intense investigation in the field, the key message of this new classification is that not all MIs are the same and that the type and extent of myocardial injury should be considered in diagnosing and treating MI. We review the literature with the goal of highlighting the progressive advances that enabled the synthesis of the Canadian Cardiovascular Society classification into 4 distinct stages of tissue injury. We emphasize the major breakthroughs …

Validation Of A Brief Food Parenting Measure For Fathers: A Test Of Factorial Validity, Measurement Invariance, Internal Reliability, And Concurrent Validity, Brian K. Lo, In Young Park, Melissa Mcternan, Yilin Wang, Alejandra Cantu-Aldana, Brent A. Mcbride, Katherine W. Bauer, Jess Haines, Kirsten K. Davison

School of Medicine Publications

Fathers are underrepresented in food parenting research partly due to the lack of succinct, theory-informed, and father-mother equivalent food parenting measurement tools. To address this, we 1) tested the factorial validity of a brief food parenting measure utilizing a subset of items from the Comprehensive Feeding Practices Questionnaire (CFPQ) to represent coercive control, structure, and autonomy support, 2) assessed the extent to which the brief tool works similarly in fathers and mothers (i.e., measurement invariance), and 3) evaluated its internal reliability and concurrent validity. Participants included 1071 fathers of children aged 2–6 years and 487 of their co-parents (mothers) from …

The Internist's Post V.1 N.12, The University Of Texas Rio Grande Valley. School Of Medicine, Eunbee Cho, Jian Garcia Cruz, Ramon Elizondo Romo, Barbara Malaga-Espinoza, Carlos Alejos Aguero, Osiris Fernandez, Roque Mifuji Lira, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

Acute Carpal Tunnel Syndrome Secondary To Handcuffs Necessitating Emergency Orthopedic Consultation And Operative Intervention, Fabian Jano, Kelly Mackenzie, Vivek Biololikar, David Goldberger, Andrei Tuluca

Department of Emergency Medicine Faculty Papers

We present a case of acute carpal tunnel syndrome secondary to tight handcuffs in a detained patient. The severity of the motor and sensory deficits prompted consultation with orthopedic specialists and admission for an observation period with ultimate emergency operative intervention. Handcuff neuropathies are well documented in the literature, mainly involving the superficial branch of the radial nerve, which has strict sensory input into the dorsum of the hand. Less common median nerve neuropathies have also been documented following handcuff injury; however, none have required emergency intervention. We aim to highlight this unusual presentation and the emergency nature of the …

Why Are Fairness Concerns So Important? Lessons From A Last-Mile Transportation System, Yiwei Chen, Hai Wang

Research Collection School Of Computing and Information Systems

The Last-Mile Problem refers to the provision of travel service for passengers from the nearest public transportation node to the final destination. The Last-Mile Transportation System (LMTS), which has recently emerged, provides on-demand last-mile transportation service for passengers. We consider an LMTS that consists of two types of passengers, regular-type passengers and special-type passengers (e.g., seniors, disabled people). The valuation of the last-mile service for special-type passengers is statistically higher than the one for regular-type passengers. Passengers incur disutility from waiting for the last-mile service. In this paper, we explore two fairness constraints on special-type passengers: (1) the fare for …

Behavioral And Neural Effects Of Distributing Visual Attention Across Location And Feature Space, Mert Özkan

Dartmouth College Ph.D Dissertations

Visual attention refers to the mechanisms by which relevant visual information, such as location, simple features (e.g., color, orientation), and objects, is selected and prioritized for further processing. The current dissertation investigates capacity limitations on spatial and feature–based attention in early visual processing and behavioral performance. Specifically, I examined whether attention could be efficiently tuned across narrow and broad ranges of locations and colors, or even be split across noncontiguous locations in the case of spatial attention. I used several behavioral paradigms and frequency–tagging methods in electroencephalography (EEG) to illustrate the effects of narrowing or broadening the attentional focus on …

Tale Of Two Requesters: How Public Records Law Experiences Differ By Requester Types, A. Jay Wagner, David Cuillier

College of Communication Faculty Research and Publications

The journalism industry was central to the materialization of U.S. freedom of information (FOI) laws, yet journalists frequently voice dissatisfaction with the state of FOI laws. The study surveyed 330 public records requesters on their experiences with FOI laws, finding public-interest requesters (journalists, academics, nonprofits, and private individuals) reported a significantly different experience, including a lower likelihood of receiving records, than for-profit requesters (commercial requesters and lawyers). For-profit requesters were less likely to believe FOI laws positively impact government accountability or improve society. The findings suggest reassessing whom the laws serve and whether they meet their original democratic objectives.

Time-Dependent Mitochondrial Remodeling In Experimental Atrial Fibrillation And Potential Therapeutic Relevance, Kalai Mangai Muthukumarasamy, Yasemin Altuntas, Yuan Zhong, Issam Abu-Taha, Florian Bruns, Marcel Tekook, Markus Kamler, Louis Villeneuve, Anna Nozza, Martin Sirois, Jason Karch, Philippe Pasdois, Donald M Bers, Dobromir Dobrev, Stanley Nattel

Faculty, Staff and Students Publications

Background: Changes in mitochondria have been implicated in atrial fibrillation (AF), but their manifestations and significance are poorly understood. Here, we studied changes in mitochondrial morphology and function during AF and assessed the effect of a mitochondrial-targeted intervention in a large animal model.

Methods and results: Atrial cardiomyocytes (ACMs) were isolated from dogs in electrically-driven AF for periods of 24 hours to 3 weeks and from humans with/without longstanding persistent AF. Mitochondrial Ca 2+ -concentration ([Ca 2+ ] Mito ), reactive oxygen species (mtROS) production, membrane potential (ΔΨ m ), permeability transition-pore (mPTP) opening and flavin adenine dinucleotide (FAD) were …

An Unclear Partnership: Key Questions About Physician And Advanced Practice Provider Collaboration In Primary Care, Susan Edgman-Levitan, Hannah Neprash, David W Bates, Lisa Rotenstein

Faculty, Staff and Students Publications

More than 83 million people in the United States live in primary care shortage areas. As the US healthcare system faces a contracting primary care physician workforce, advanced practice providers are playing an increasingly important role in the delivery of primary care services. In parallel, public discourse regarding the differences in care delivery by advanced practice providers versus physicians has also expanded. In this commentary, we describe 3 main evidence gaps hindering optimal physician and advanced practice provider work organization in contemporary primary care delivery: (1) gaps in understanding the unique and overlapping competencies of each role group, (2) gaps …

A Head-To-Head Comparison Of Situational Judgment Tests And Assessment Centers For Measuring And Predicting The Same Performance Dimensions, Iman Shakeri, Filip Lievens

Research Collection Lee Kong Chian School Of Business

To date, a limited set of studies have compared the criterion-related validity of low-fidelity (SJT) versus high-fidelity (AC) simulations for predicting job performance. Unfortunately, these studies validated these simulations through the overall assessment rating (OAR) instead of on the basis of specific dimensions. Given SJTs and ACs were compared that measured different dimensions, our understanding of the relative and comparative validity of these assessment approaches in measuring the same set of dimensions is still limited. Therefore, this study aims to conduct a head-to-head comparison of the criterion-related validity of the AC and the SJT (and their incremental validity) while keeping …

The Boundaries Of The Law: Can Us Private Enforcement Discipline Foreign Firms?, Massimo Massa, Xiaoqiao Wang, Bohui Zhang, Hong Zhang

Research Collection Lee Kong Chian School Of Business

Existing studies tend to focus on how a legal system reinforces the efficiency of its domestic firms or foreign companies that are subject to its domestic jurisdiction (e.g., via cross-listing). Our study provides critical normative implications in the era of financial globalization by showing that the influence of a country’s legal institutions extend beyond its territorial boundaries. We examine whether US shareholder-initiated class action lawsuits can discipline non-US firms. Using an international sample of firms over the period 1994–2019, we find that a US class action lawsuit against a non-US firm cross-listed in the US negatively affects the value of …

Technology-Enhanced Personalized Learning: Lessons From Online Teaching At Three South-East Asian Universities, Kiran Kaur, Rohaida Mohd Saat, Lieven Demeester, Magdeleine Lew, Wei Leng Neo, Nopphol Pausawasdi, Thasaneeya Ratanaroutai Nopparatjamjomras

Research Collection Lee Kong Chian School Of Business

Online teaching during the COVID-19 pandemic compelled many instructors to seek efficient and effective ways to stay connected with their students and improve the learning experience by using a wide range of available technologies. This multiple-case study, in three South-East Asian universities, investigated whether the use of technology in university teaching and learning during that period influenced personalized learning, and if so, how. The study also explored the kinds of institutional support for teachers and learners that led to increased technology-enhanced personalized learning (TEPL). Using a qualitative approach, the study analyzed 23 individual interviews and 3 document analyses (circulars, announcements, …

Effects Of Applicants' Use Of Generative Ai In Personnel Selection: Towards A More Nuanced View?, Filip Lievens, Patrick D. Dunlop

Research Collection Lee Kong Chian School Of Business

Generative AI (GenAI) has made rapid inroads in assessment, as a growing number of applicants rely on it as a coach in unproctored assessments of various selection procedures. This had led to assertions that applicants' GenAI use undermines key assumptions of the predictive model underlying selection and is thus disruptive for organizations' current unproctored assessments, thereby invoking various strategies of organizations to deter and detect its use. In this provocation article, we present a more nuanced view. To this end, we start by reviewing the recent research related to the effects of applicants' use of GenAI in assessment and discuss …

When Leaders Self-Sacrifice In Times Of Crisis: The Roles Of Employee Emotional Suppression And Leader Coping Strategies, Xingyu Wang, Xueqi Wen, Zihan Liu, Yixing Lisa Gao, Juan M. Madera

Research Collection Lee Kong Chian School Of Business

While literature articulates the relevance of self-sacrificial leadership to crisis situations, little attention has been paid to employees’ attitudinal and behavioral responses to self-sacrificial leadership. This is a particularly salient gap in the scholarship, given the decisions leaders must make to address challenges in the hospitality industry (e.g., the COVID-19 pandemic). Drawing on conservation of resources theory, this pair of field and experimental studies examines how individual differences in employee emotional suppression and leader coping strategy moderate the impacts of self-sacrificial leadership on employee perceptions of leader effectiveness. By sampling U.S. hospitality employees, the studies reveal that leaders who display …

Exploring The Dynamics Of Volitional Personality Change: A Psychoeducational Intervention Study With Young Adults Transitioning To The Workforce, Erica Baranski, Ramona L. Martinez, Zihan Liu, Kevin Hoff

Research Collection Lee Kong Chian School Of Business

College graduates transitioning to the workforce completed a 13-week, light, psychoeducation intervention designed to increase volitional personality change motivation via weekly email newsletters. Contrary to expectations, the intervention did not significantly enhance overall change motivation or consistently inspire desired trait change goals following the study period or after 6 or 10 months. However, participants in the intervention group did report increased desire to change emotional stability at specific points during the study. These findings underscore the limitations of this particular psychoeducational intervention approach and help to fill in the boundary conditions of when and how personality change is possible. Additionally, …

Minimal Clinically Important Difference In Obsessive-Compulsive Disorder, Erik Andersson, Christian Rück, Daniel A Geller, David Mataix-Cols

Faculty, Staff and Students Publications

No abstract provided.

Comparative Single-Cell Analysis Reveals Tendon Progenitor Dysfunction By Age-Associated Oxidative Stress And Its Restoration By Antioxidant Treatments, Laura Ortinau, Dongsu Park

Faculty, Staff and Students Publications

Impaired healing of adult tendons with fibrosis remains clinical challenges while neonatal tendons have full functional restoration. However, age-associated cellular and molecular changes in tendon cells and tendon stem/progenitor cells (TSPCs) remain unknown. Here, comparative single cell transcriptomics of early postnatal (2 weeks old) and adult (20 weeks old) mouse tendons revealed that adult tendons have reduced number of TSPCs, decreased gene expression in tendon and cartilage development, and a greater population of fibro-tenogenic cells. Notably, adult TSPCs and tenocytes exhibit increased expression of immune-response and oxidative-stress genes with higher EGFR but decreased IGF signaling. Adult tendon cells show increased …

Uncovering Specific Genetic-Respiratory Disease Endotypes For Rheumatoid Arthritis Risk, Elizabeth J Atkinson, Cynthia S Crowson, Xiaosong Wang, Jing Cui, James R Cerhan, Jennifer A Sletten, Gregory C Mcdermott, Elena K Joerns, Robert Vassallo, John M Davis, Jeffrey A Sparks

Faculty, Staff and Students Publications

Objective: We aimed to identify specific genetic-respiratory disease endotypes for rheumatoid arthritis (RA) risk.

Methods: This case-control study used the Mass General Brigham (MGB) and Mayo Clinic (MC) Biobanks for discovery and replication, respectively. We matched criteria-confirmed incident RA cases to four non-RA controls on age, sex and health record history. Genetic exposures included the top 11 RA risk alleles, and a validated human leucocyte antigen (HLA) genetic risk score (GRS). We identified seven respiratory diseases by codes. Using logistic regression models adjusting for potential confounders, we estimated Rs with 95% CIs for the interactions between genetic and respiratory exposures …