Digital Commons Network^™

Towards Characterizing And Quantifying Interpretability Of Knowledge Graph Embedding Models, Narayanan Asuri Krishnan

Theses

Knowledge graphs are structured representations of real-world information, where entities are connected by edges with labels known as predicates. These graphs contain logical patterns, known as inference patterns, such as symmetry, transitivity and composition, to name a few. To leverage the information contained within a knowledge graph, embedding methods have been developed to encode entities and predicates as numerical vectors in a multi-dimensional space. These embeddings aim to capture the semantic and structural information of the graph, including the inference patterns. However, the sub-symbolic nature of these embeddings present significant challenges in terms of interpretability. Additionally, each embedding model utilizes …

A Wayfarer, Roselyle Hang Zhao

Theses

This paper examines the making of A Wayfarer, a personal film that explores themes of identity, cultural belonging, and the experience of being a third-culture individual. The character Boaty represents the complexities of navigating multiple identities, as the film blends visual and sound design to convey the feeling of being "lost-in-culture." As part of my graduate thesis at the Rochester Institute of Technology, the film blends visual and sound design to convey the feeling of being "lost-in-culture." The paper discusses the creative choices behind the shift from humor to vulnerability, the challenges of depicting family dynamics, and the process of …

Reusing Underutilized Warehouses: Impact Of Iot Integration On Water Conservation In Hydroponic Farming Within Mina Zayed Warehouses In Abu Dhabi, Aysha Benyas

Theses

Urban farming is seen as an essential approach to sustainable development, particularly in arid regions like Abu Dhabi, United Arab Emirates, where limited arable land and water resources pose significant challenges. With an emphasis on reusing underutilized urban spaces like the industrial warehouses in Mina Zayed, this thesis explores the transformative potential of shifting from conventional agricultural methods to advanced smart farming approaches. The main objective of this project is to optimize the effective use of urban areas and improve water conservation in agricultural operations by integrating Internet of Things (IoT) technology into hydroponic systems within these warehouses. The research …

Advancing Literary Interpretation Via Critical Reading Proficiency: A Sustainable Efl Framework For Generation Z, Wesam Khairy Morsi, Walid Abdallah Rezk

English Language and Literature

Abstract—This research investigates the transformative potential of literary analysis in advancing English proficiency among Egyptian EFL learners, particularly those in the Faculty of Arts and Humanities. The study focuses on the linguistic and analytical challenges encountered by recent public-school graduates in the Suez Governorate, where English instruction is limited to simplified texts and lacks critical engagement. Unlike their counterparts from language schools in Cairo, these students enter university without placement tests, relying solely on their high school grades, which results in underdeveloped critical reading and thinking skills. Sixty Egyptian students participated in this experimental quantitative research design. Drawing on the …

A Comprehensive Study Of Cooling Rate Effects On Diffusion, Microstructural Evolution, And Characterization Of Aluminum Alloys, Atiqur Rahman, Sriram Praneeth Isanaka, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Cooling Rate (CR) definitively influences the microstructure of metallic parts manufactured through various processes. Factors including cooling medium, surface area, thermal conductivity, and temperature control can influence both predicted and unforeseen impacts that then influence the results of mechanical properties. This comprehensive study explores the impact of CRs in diffusion, microstructural development, and the characterization of aluminum alloys and the influence of various manufacturing processes and post-process treatments, and it studies analytical models that can predict their effects. It examines a broad range of CRs encountered in diverse manufacturing methods, such as laser powder bed fusion (LPBF), directed energy deposition …

Custom’S Pervasive Role In Law And The Boundaries Of Positivism, James Paul George

Faculty Scholarship

Custom is law’s foundation, modulator, and occasional antithesis. This Article explores that relationship, starting with varying insights from some of the few legal philosophers who have examined the custom/law dynamic. The heart of this Article provides examples showing custom’s many influences on the law, set in five functional areas: origin, application, interstitial, rule-source, and oppositional. Although the custom/law interplay spans human behavior, these examples come from law practice where custom is exposed. Many are routine, some are significant, and all show our reliance on behaviors and norms that are not positive law. The conclusion addresses but does not resolve some …

We Need To Talk: Modernizing Attorney-Client Jail Communications, Cynthia Alkon

Faculty Scholarship

Attorney-client jail phone calls, video calls, and emails are all routinely recorded and monitored by jails, with numerous examples of jails and private telecommunications providers giving those recordings and emails to law enforcement and prosecutors. This widespread failure to protect the confidentiality of attorney-client communications prevents lawyers from being able to enjoy easy, quick, and regular communications with their clients. In practice, and despite the ever-expanding communication methods in the outside world, those held in jails in this country while their criminal cases are pending are effectively stuck in the nineteenth century when the only way to communicate was in …

Water Reallocation In The West: Government And Markets, Vanessa Casado Pérez

Faculty Scholarship

Water is multifaceted: it is a human right, a production input, a sacred element, an investment asset, public property, and a fugitive resource. Its reallocation is inherently difficult because of its natural characteristics and its hybrid nature that combines public ownership with private rights. The future of the U.S. West necessitates the reallocation of water resources, even with potential new water supplies. As climate change intensifies, reallocation will take various forms—all involving government intervention to some degree, from eminent domain to competitive markets. For water markets to function effectively, they require robust institutional infrastructure to prevent issues like imperfect information …

Feedbacks Between Fjord Circulation, Mélange Melt, And The Subglacial Discharge Plume At Kangerlussuaq Glacier, East Greenland, M. Wood, I. Fenty, A. Khazendar, J. K. Willis

Faculty Research, Scholarly, and Creative Activity

In recent decades, the Greenland ice sheet has been losing ice and contributing substantially to global sea level rise. Approximately half of this recent loss is due to glacier acceleration, increasing the calving of icebergs into the ocean. This process has been linked with increased ocean heat content on the continental shelf, yet the pathways delivering this heat into Greenland's fjords and its interactions with fjord-scale processes modulating glacier ice loss are still unclear. In this study, we use a series of numerical ocean model configurations to examine feedbacks between ocean circulation, subglacial discharge, submarine glacier melt, and ice mélange …

Order-2 Delaunay Triangulations Optimize Angles, Herbert Edelsbrunner, Alexey Garber, Morteza Saghafian

School of Mathematical & Statistical Sciences Faculty Publications

The local angle property of the (order-1) Delaunay triangulations of a generic set in R2" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; position: relative;">R2R2 asserts that the sum of two angles opposite a common edge is less than π. This paper extends this property to higher order and uses it to generalize two classic properties from order-1 to order-2: (1) among the complete level-2 hypertriangulations of a generic point set in R2" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; position: relative;">R2R2, the order-2 Delaunay triangulation lexicographically maximizes the sorted angle vector; (2) among the maximal level-2 hypertriangulations …

Improving Outcomes Of Depression Through Implementation Of Depression Screenings At A College Health Center, Shelby Leigh Hanigan

Electronic Theses and Dissertations

Depression is a common phenomenon. Depression and suicidality are a problem on university campuses. This quality improvement Doctor of Nursing project aimed to establish the importance of routine depression screenings within a college health clinic. The purpose of this project was to determine if implementing routine depression screenings at a university health clinic will or will not increase the number of counseling referrals when compared to the absence of depression screenings in place within an identified timeframe. This protocol screened for depression in college-aged students and suggested care to those students who screened positive. It also led an interprofessional team …

K–12 Educators’ Use Of Technology And Experiences With Technostress: A Case Study, Greg Blair Pittman

Electronic Theses and Dissertations

Abstract

This dissertation explored the increased use of technology in K–12 classrooms, which is causing educators to experience technostress. The purpose of the qualitative, descriptive, single case study was to explore the experiences of K–12 teachers with technology and technostress—techno-insecurity, techno-invasion, techno-complexity, techno-uncertainty, and techno-overload—in a West Texas private school district. The researcher conducted one-to-one interviews with seven K-12 educators and two senior leadership team members. In addition, open-ended online questionnaires were available for K–12 educators and senior leadership team members. Thematic analysis was used to locate and communicate the findings. The principal research question was: How do K–12 classroom …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn-Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

A Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+ T Cells That Respond To Immunotherapy, William W. Tang, Ben Battistone, Kaylyn M. Bauer, Allison M. Weis, Cindy Barba, Muhammad Zaki Hidayatullah Fadlullah, Arevik Ghazaryan, Van B. Tran, Soh-Hyun Lee, Z. Busra Agir, Morgan C. Nelson, Emmanuel Stephen Victor, Amber Thibeaux, Colton Hernandez, Jacob Tantalla, Aik C. Tan, Dinesh Rao, Matthew Williams, Micah J. Drummond, Ellen J. Beswick, June L. Round, H. Atakan Ekiz, Warren P/ Voth, Ryan M. O’Connell

Markey Cancer Center Faculty Publications

The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8 + T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8 + T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based …

Staying Sane In The Membrane: Neutral Sphingomyelinase 2 As A Master Regulator Of Plasma Membrane Ceramide, Zainuddin Quadri, Erhard Bieberich

Markey Cancer Center Faculty Publications

Ceramide, a key signaling sphingolipid in the plasma membrane, plays a pivotal role in fundamental cellular processes such as adhesion, polarity, and programmed cell death. The generation of plasma membrane ceramide is largely attributed to the activity of two types of sphingomyelinases: neutral sphingomyelinase 2 (nSMase2, Smpd3) and acid sphingomyelinase (aSMase, Smpd1). While many studies have explored ceramide generation following experimental activation of these enzymes, the mechanisms governing basal or steady- state ceramide levels have remained poorly understood. Using an innovative mass spectrometry approach developed in the Canals’ lab, the team has quantified the distinct contributions of nSMase2 and aSMase …

Bilirubin Bioconversion To Urobilin In The Gut-Liver-Kidney Axis: A Biomarker For Insulin Resistance In The Cardiovascular-Kidney-Metabolic (Ckm) Syndrome, Zachary A. Kipp, Olufunto O. Badmus, David E. Stec, Brantley Hall, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

The rising rates of obesity worldwide have increased the incidence of cardiovascular disease (CVD), making it the number one cause of death. Higher plasma bilirubin levels have been shown to prevent metabolic dysfunction and CVD. However, reducing levels leads to deleterious outcomes, possibly due to reduced bilirubin half-life that escalates the production of its catabolized product, urobilinogen, produced by gut bacteria and naturally oxidized to urobilin. Recent findings suggest that the involvement of the microbiome catabolism of bilirubin to urobilin and its absorption via the hepatic portal vein contributes to CVD, suggesting a liver-gut axis involvement. We discuss the studies …

Ddo-Adjuvanted Influenza A Virus Nucleoprotein Mrna Vaccine Induces Robust Humoral And Cellular Type 1 Immune Responses And Protects Mice From Challenge, Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

Markey Cancer Center Faculty Publications

A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8+ T-cells that target conserved viral proteins and can eliminate infected cells to control virus spread. mRNA technology offers an opportunity to design vaccines based on conserved CD8-targeting epitopes, but achieving robust antigen-specific CD8+ T-cells remains a challenge. Here, we tested the viral-derived oligonucleotide DDO268 as an adjuvant in the context of a model influenza A virus (IAV) nucleoprotein (NP) mRNA vaccine in C57BL/6 mice. DDO268 when co-packaged with mRNA in lipid nanoparticles is sensed by RIG I-like receptors and …

The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T- ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn- Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

Potential Mental Disorder Symptoms In The Prophet Elijah: An Exegetical And Psychological Analysis Of Selected Episodes From 1 Kings 18–19, Dariusz Iwański, Thomas G. Plante

Psychology

This interdisciplinary study examines the prophet Elijah’s experiences as depicted in 1 Kings 18–19 through a multidisciplinary lens, combining theological, literary, and psychological perspectives. Drawing on literary and historical–critical methods, a biblical scholar analyzes the narrative’s linguistic and cultural dimensions, while a psychologist evaluates these findings using contemporary mental health frameworks, including the DSM-5 and models of spiritual struggle. By synthesizing these approaches, the study explores Elijah’s emotional challenges, highlighting their resonance with modern understandings of mental health and spirituality. The findings suggest that Elijah’s profound struggles—marked by triumph, despair, and renewal—offer valuable insights into the interplay of faith, vulnerability, …

Raíces Salvadoreñas, Sueños Americanos (Salvadoran Roots, American Dreams), Katherine Y. Posada

Electronic Theses, Projects, and Dissertations

Raíces Salvadoreñas, Sueños Americanos (Salvadoran Roots, American Dreams) is an interdisciplinary body of work that navigates the common threads between identity, memory, and heritage through an intimate and layered approach. Rooted in personal experience, the work is deeply informed by my identity as the daughter of Salvadoran immigrants, shaped equally by the cultural richness of El Salvador and the complexities of growing up in the United States. Through ceramics, installation, found objects, and video, I translate familial stories and cultural practices into tangible forms objects and environments that embody both vulnerability and resilience.

This work is an homage to the …

Duration Of Labor And Umbilical Artery Acidosis In Critical Congenital Heart Disease, Sarah Gwazdacz, Teresa Nguyen, Henry Yeh, Mary T. Donofrio, Timothy Bennett, Amanda Mcintosh

Posters

• Background (83 words): Standard delivery protocols for most prenatally diagnosed CCHD is induction of labor at 39 weeks with aims of a vaginal delivery (VD) near a tertiary care center. There is no benefit to planned Cesarean delivery (CD) over VD for most infants with CCHD. However, longer durations of labor (DOL) in CCHD have been described as a risk factor for umbilical artery (UA) acidosis. We aim to describe the relationship between DOL and UA pH and neonatal outcomes in those with prenatally diagnosed CCHD. • Methods (150 words): Retrospective chart review of prenatally diagnosed with CCHD born …

Tracking Community Outreach And Engagement Activities Among National Cancer Institute-Designated Cancer Centers, Todd Burus, Caree Mcafee, Pamela Hull, Amy Leader, Christopher Mcnair

Kimmel Cancer Center Faculty Papers

The National Cancer Institute's (NCI) Cancer Center Support Grant mandates that NCI-designated cancer centers establish a Community Outreach and Engagement (COE) component to help direct efforts at reducing cancer burden within their catchment areas. Despite the critical role of COE offices, little is known about how they track and evaluate outreach activities and outcomes. We gathered information on current practices from representatives of 40 out of 65 COE offices using an online survey. Although nearly all responding centers (97.5%) tracked COE activities, no consensus existed on resources used, and satisfaction with current solutions was mixed (51.0% not satisfied). Respondents expressed …

Evaluating The Generalisability Of Region-Naïve Machine Learning Algorithms For The Identification Of Epilepsy In Low-Resource Settings, Ioana Duta, Symon M. Kariuki, Anthony Ngugi, Angelina Kakooza Mwesige, Honorati Masanja, Daniel M. Mwanga, Seth Owusu-Agyei, Ryan Wagner, J Helen Cross, Josemir W. Sander W. Sander

Population Health, East Africa

Objectives: Approximately 80% of people with epilepsy live in low- and middle-income countries (LMICs), where limited resources and stigma hinder accurate diagnosis and treatment. Clinical machine learning models have demonstrated substantial promise in supporting the diagnostic process in LMICs by aiding in preliminary screening and detection of possible epilepsy cases without relying on specialised or trained personnel. How well these models generalise to naïve regions is, however, underexplored. Here, we use a novel approach to assess the suitability and applicability of such clinical tools to aid screening and diagnosis of active convulsive epilepsy in settings beyond their original training contexts. …

Glp-1ra And Sglt2i Utilization In People With Type 2 Diabetes With Atherosclerotic Cardiovascular Disease (Ascvd) Or At High Risk Of Ascvd In The Gulf Region: Results From The Pact-Mea Studys, Waleed A. Al-Dahi, Saeed H. Khalaf, Dalal A. Alromaihi, Naji M. Alamuddin, Doaa K. Abdalla, Hanan Y. Alfadehla, Amin A. Jayyousi, Mashhood A. Siddique, Usama A. Alalami, Guruprasad C. Subbarao, Shashikanth J. Chetty, Jehan A. Abdulla

Saudi Medical Journal

Objectives: To provide insights into the real-world usage of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) among individuals with type 2 diabetes (T2D) from Bahrain, Kuwait, and Qatar who either had established atherosclerotic cardiovascular disease (eASCVD) or were at high risk of developing ASCVD. Methods: This study of 1062 adults diagnosed with T2D from Bahrain, Kuwait, and Qatar is a sub-analysis within the Prevalence and Clinical Management of Atherosclerotic Cardiovascular Diseases in Patients with Type 2 Diabetes across Countries in the Middle East and Africa (PACT-MEA) study, a noninterventional, cross-sectional study. Participants were recruited from 13 …

Quality Of Life Improvement In Children With Otitis Media With Effusion Post Ventilation Tube Insertion: A Prospective Cohort Study, Abdullah S. Alkhaldi, Lama M. Alsahli, Sultan A. Al-Ibraheem, Muataz H. Alhashem, Fahad A. Al-Saab

Saudi Medical Journal

Objectives: To study is to establish the OM-6 scores in Saudi children with OME and subjectively assess the change in QoL following VT insertion. The Otitis Media 6 (OM-6) questionnaire is a widely used measure of the quality of life (QoL) in children with otitis media with effusion (OME). Myringotomy with ventilation tube (VT) insertion is indicated when OME persists with clinically documented hearing impairment. Methods: The present study is a prospective cohort study investigating the QoL of children with OME using a validated OM-6 questionnaire. The caregivers of 100 children were subjected to the questionnaire preoperatively from January 2023 …

Cochlear Implantation At King Abdallah Medical City, Makkah, Saudi Arabia: Single Institution Experience, A 5-Years Retrospective Analysis, Shatha Y. Alqahtani, Shuruq M. Almasoudi, Zohour A. Almalki, Khalid M. Badr, Saeed A. Alghamdi, Fares E. Alghamdi

Saudi Medical Journal

Objectives: To review the outcomes of the cochlear implantation program at King Abdallah Medical Center (KAMC) in Makkah from its launch in 2018 to 2023, focusing on patient demographics, procedural details, and complications. Methods: A retrospective analysis was conducted on 133 patients who underwent cochlear implantation (CI) at KAMC between May 2018 and June 2023. Data collected included demographics, hearing loss types, anatomical findings from imaging, types of CI devices, procedural challenges, and complications. Results: The average age of the patients was 9 years (108 months) with 56.4% males and 96.2% Saudi nationals. Most patients (50.4%) were from Makkah, and …

Shifting Sands: Unveiling The Changes In Respiratory Comorbidities And Fungal Pathogens In Saudi Arabia, Aiah M. Khateb, Fadwa S. Alofi, Mohammad A. Alturkostani, Abdullah Z. Almutairi

Saudi Medical Journal

Objectives: To investigate epidemiological changes in respiratory fungal infections (RFI), including fungal isolation and colonization, at one of the main centers in Medina. The incidence of RFI is rising due to an increase in the number of immunocompromised individuals, a higher prevalence of respiratory viral infections, and an aging population. Methods: A retrospective cross-sectional study was conducted by extracting data of patients with fungal-positive respiratory cultures from King Fahad Hospital (KFH), Al Madinah Al Munawwarah from 2013 to 2023. Results: A total of 352 episodes of fungal-positive cultures were identified in 79 patients, reflecting a 12-fold increase in RFI prevalence. …

Major General Dr. Ketab Al-Otaibi (1943- 2024)

Saudi Medical Journal

No abstract provided.

Giant Left Gastric Artery Aneurysm With Intrathoracic Extension, Ayhan Akcali, Bilal Ogan, Celal Buğra Sezen, Muzaffer Metin

Saudi Medical Journal

ABSTRACT Splanchnic artery aneurysms, particularly those involving the left gastric artery, are infrequent occurrences and often lack noticeable symptoms, but their rupture involves a significant risk of mortality. We present a case involving an unruptured left gastric artery aneurysm (LGAA) that extended into the right hemithorax. This case report outlines the categorization, clinical manifestations, and diagnostic challenges associated with such aneurysms. Our findings could offer valuable insights for clinicians and radiologists when adopting a systematic approach for the early detection and management of LGAA.