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Articles 239611 - 239640 of 5210932
Full-Text Articles in Entire DC Network
Variations In Hawaiian Plume Flux Controlled By Ancientmantle Depletion, Paul Béguelin, Andreas Stracke, Maxim D. Ballmer, Shichen Huang, Michael Wilig, Michael Bizimis
Variations In Hawaiian Plume Flux Controlled By Ancientmantle Depletion, Paul Béguelin, Andreas Stracke, Maxim D. Ballmer, Shichen Huang, Michael Wilig, Michael Bizimis
Faculty Publications
Mantle plumes—upwellings of buoyant rock in Earth's mantle—feed hotspot volcanoes such as Hawai‘i. The size of volcanoes along the Hawai‘i–Emperor chain, and thus the magma flux of the Hawaiian plume, has varied over the past 85 million years. Fifteen and two million years ago, rapid bursts in magmatic production led to the emergence of large islands such as Pūhāhonu, Maui Nui and Hawai‘i, but the underlying mechanisms remain enigmatic. Here, we use new radiogenic Ce–Sr–Nd–Hf isotope data of Hawaiian shield lavas to quantify the composition and proportion of the different constituents of the Hawaiian plume over time. We find that …
Infection-Related Hospitalization And Incident Heart Failure: The Atherosclerosis Risk In Communities Study, Jeffrey R Misialek, Richard Maclehose, Barry A Borlaug, Paolo C Colombo, Chiadi E Ndumele, Junichi Ishigami, Kunihiro Matsushita, Pamela L Lutsey, Ryan T Demmer
Infection-Related Hospitalization And Incident Heart Failure: The Atherosclerosis Risk In Communities Study, Jeffrey R Misialek, Richard Maclehose, Barry A Borlaug, Paolo C Colombo, Chiadi E Ndumele, Junichi Ishigami, Kunihiro Matsushita, Pamela L Lutsey, Ryan T Demmer
Faculty, Staff and Student Publications
Background: The immune response to infections may become dysregulated and promote myocardial damage contributing to heart failure (HF). We examined the relationship between infection-related hospitalization (IRH) and HF, HF with preserved ejection fraction, and HF with reduced ejection fraction.
Methods and results: We studied 14 468 adults aged 45 to 64 years in the ARIC (Atherosclerosis Risk in Communities) Study who were HF free at visit 1 (1987-1989). IRH was identified using select International Classification of Diseases (ICD) codes in hospital discharge records and was treated as a time-varying exposure. HF incidence was defined as the first occurrence …
Neonatal Care In Low- And Middle-Income Countries: A Fresh Look, Ola D. Saugstad, Joy E. Lawn, Peter Waiswa, Zulfiqar Ahmed Bhutta
Neonatal Care In Low- And Middle-Income Countries: A Fresh Look, Ola D. Saugstad, Joy E. Lawn, Peter Waiswa, Zulfiqar Ahmed Bhutta
Institute for Global Health and Development
No abstract provided.
New And Revised Groundwater Snails (Mollusca, Caenogastropoda, Cochliopidae) From Karst And Associated Hyporheic Habitats In Western Texas And Northern Mexico, Kathryn E. Perez, Vanessa Saenz, Yamileth Guerrero, Lisa Gonzalez, Evan Guerrero, Pete Diaz, Benjamin T. Hutchins, Benjamin F. Schwartz
New And Revised Groundwater Snails (Mollusca, Caenogastropoda, Cochliopidae) From Karst And Associated Hyporheic Habitats In Western Texas And Northern Mexico, Kathryn E. Perez, Vanessa Saenz, Yamileth Guerrero, Lisa Gonzalez, Evan Guerrero, Pete Diaz, Benjamin T. Hutchins, Benjamin F. Schwartz
School of Integrative Biological & Chemical Sciences Faculty Publications
The freshwater gastropod family Cochliopidae is a diverse component of the subterranean fauna in the karst and hyporheic habitats of western Texas and northern Mexico, with 11 genera and 27 described species found in the region. Building on previous phylogenetic studies of the family in the region we incorporate additional sampling, DNA, and morphological study for systematic revision of species found in the western Edwards-Trinity Aquifer System and associated karst and hyporheic habitats. We describe three new species, Stygopyrgus variabilis sp. nov., Stygopyrgus gracilis sp. nov., and Phreatodrobia embossa sp. nov. and revise the generic placement of two …
20250204: University Communications, 1940-2012, University Communications
20250204: University Communications, 1940-2012, University Communications
Guides to University Archives
These items include materials from the office of University Communications at Marshall University from 1940-2012. Items were received before 2022 and include notable materials including a Marshall University Cookbook (2005), some Parthenon issues, a copy of the book "A Coach in Progress: Marshall Football: A Story of Survival and Revival" , some letters and news clippings, some Marshall University Greenline Newsletters, and a 1940 copy of the student yearbook The Chief Justice. Please download the full list of contents.
State Of Utah Appellee/ Plaintiff V. Ryan Scott Hatch Appellant/Defendant : Brief Of Appellee, Utah Court Of Appeals
State Of Utah Appellee/ Plaintiff V. Ryan Scott Hatch Appellant/Defendant : Brief Of Appellee, Utah Court Of Appeals
Utah Court of Appeals Briefs (2020 –)
Appeal from a conviction for wanton destruction of wildlife, a third degree felony, in the Sixth Judicial District, Kane County, the Honorable Mandy Larsen presiding
SCOTT F. GARRETT, JESSICA GRIFFIN ANDERSON, Counsel for Appellant
NATALIE M. EDMUNDSON, DEREK E. BROWN, JEFFREY N. STOTT, Counsel for Appellee
Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial., Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal T Gandhi, Keith Pereira, Jay Giri, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson
Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial., Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal T Gandhi, Keith Pereira, Jay Giri, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson
Heart and Vascular Articles
BACKGROUND: There are a lack of randomized controlled trial data comparing outcomes of different catheter-based interventions for intermediate-risk pulmonary embolism.
METHODS: PEERLESS is a prospective, multicenter, randomized controlled trial that enrolled 550 patients with intermediate-risk pulmonary embolism with right ventricular dilatation and additional clinical risk factors randomized 1:1 to treatment with large-bore mechanical thrombectomy (LBMT) or catheter-directed thrombolysis (CDT). The primary end point was a hierarchal win ratio composite of the following (assessed at the sooner of hospital discharge or 7 days after the procedure): (1) all-cause mortality, (2) intracranial hemorrhage, (3) major bleeding, (4) clinical deterioration and/or escalation to …
Durable Responses To Immune Checkpoint Inhibitor-Based Regimens For Metastatic Clear Cell Renal Cell Carcinoma Stratified By Imdc Risk Groups: A Pooled Analysis Of Four Randomized Phase 3 Trials, Albert Jang, Jeffrey Y. Zhong, Hamsa L.S. Kumar, Kevin K. Zarrabi, Alec Zhu, Abby L. Grier, Adam Calaway, Jonathan E. Shoag, Laura Bukavina, Angela Y. Jia, Prateek Mendiratta, Iris Y. Sheng, Santosh Rao, Jason R. Brown, Jorge A. Garcia, Seunghee Margevicius, Pingfu Fu, Pedro C. Barata
Durable Responses To Immune Checkpoint Inhibitor-Based Regimens For Metastatic Clear Cell Renal Cell Carcinoma Stratified By Imdc Risk Groups: A Pooled Analysis Of Four Randomized Phase 3 Trials, Albert Jang, Jeffrey Y. Zhong, Hamsa L.S. Kumar, Kevin K. Zarrabi, Alec Zhu, Abby L. Grier, Adam Calaway, Jonathan E. Shoag, Laura Bukavina, Angela Y. Jia, Prateek Mendiratta, Iris Y. Sheng, Santosh Rao, Jason R. Brown, Jorge A. Garcia, Seunghee Margevicius, Pingfu Fu, Pedro C. Barata
Department of Medical Oncology Faculty Papers
Background: An immune checkpoint inhibitor (ICI) backbone is a standard of care for frontline metastatic clear cell renal cell carcinoma, involving either ICI doublet or tyrosine kinase inhibitor (TKI) with ICI. These phase 3 trials used a sunitinib control arm. The optimal regimen is uncertain. Objective: To compare long-term responders of these trials using extended follow-up data stratified by International Metastatic RCC Database Consortium risk group. Methods: Phase 3 trial data (CheckMate 214, KEYNOTE-426, CheckMate 9ER, and CLEAR) with a minimum follow-up of four years was used. Pseudo individual patient data (IPD) was obtained from Kaplan-Meier curves using the graph …
The Misalignment Of Incentives In Academic Publishing And Implications For Journal Reform, Jennifer S Trueblood, David B Allison, Sarahanne M Field, Ayelet Fishbach, Stefan D M Gaillard, Gerd Gigerenzer, William R Holmes, Stephan Lewandowsky, Dora Matzke, Mary C Murphy, Sebastian Musslick, Vencislav Popov, Adina L Roskies, Judith Ter Schure, Andrei R Teodorescu
The Misalignment Of Incentives In Academic Publishing And Implications For Journal Reform, Jennifer S Trueblood, David B Allison, Sarahanne M Field, Ayelet Fishbach, Stefan D M Gaillard, Gerd Gigerenzer, William R Holmes, Stephan Lewandowsky, Dora Matzke, Mary C Murphy, Sebastian Musslick, Vencislav Popov, Adina L Roskies, Judith Ter Schure, Andrei R Teodorescu
Children’s Nutrition Research Center Staff Publications
For most researchers, academic publishing serves two goals that are often misaligned-knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can also pressure scholars to maximize publication metrics. Commercial publishing companies have capitalized on the centrality of publishing to the scientific enterprises of knowledge dissemination and academic recognition to extract large profits from academia by leveraging unpaid services from reviewers, creating financial barriers to research dissemination, and imposing substantial fees for open access. We present a set of perspectives exploring alternative models for communicating and disseminating scientific research. Acknowledging that …
Infrared Cooling In An Anharmonic Cascade Framework: 2-Cyanoindene, The Smallest Cyano-Pah Identified In Tmc-1, Mark H. Stockett, Vincent J. Esposito, Eleanor K. Ashworth, Ugo Jacovella, James N. Bull
Infrared Cooling In An Anharmonic Cascade Framework: 2-Cyanoindene, The Smallest Cyano-Pah Identified In Tmc-1, Mark H. Stockett, Vincent J. Esposito, Eleanor K. Ashworth, Ugo Jacovella, James N. Bull
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Infrared (IR) cooling of polycyclic aromatic hydrocarbon (PAH) molecules is a major radiative stabilization mechanism of PAHs present in space and is the origin of the aromatic infrared bands (AIBs). Here, we report an anharmonic cascade model in a master equation framework to model IR emission rates and emission spectra of energized PAHs as a function of internal energy. The underlying (simple harmonic cascade) framework for fundamental vibrations has been developed through the modeling of cooling rates of PAH cations and other carboneaous ions measured in electrostatic ion storage ring experiments performed under “molecular cloud in a box” conditions. The …
Discovery And Functional Characterization Of Biomarkers In Clear Cell Renal Cell Carcinoma, Wagma Caravan
Discovery And Functional Characterization Of Biomarkers In Clear Cell Renal Cell Carcinoma, Wagma Caravan
Arts & Sciences Graduate Student Theses and Dissertations
Not all tumors are created equally, nor should they be treated as such. Modern research has uncovered a multitude of genetic aberrations, genomic dysregulation, and epigenetic modifications that contribute to cancer. While cancers are classified based on their tissue of origin and may share common features or pathways, the tumor microenvironment is far from uniform. It comprises a dynamic network of cell populations with divergent genomic profiles, all of which collectively drive tumor progression—with some tumors more efficient and aggressive than others. The heterogeneity within these tumors makes it notoriously harder to treat, as standard therapies fail to address the …
Integrating Zotero With Your Writing: From Research To Publication, Evelyn Wang
Integrating Zotero With Your Writing: From Research To Publication, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This workshop presentation provides a comprehensive guide on using Zotero for research and writing. It covers installation, reference collection, organization, citation insertion, bibliography generation, PDF management, and advanced features of Zotero. The presentation aims to enhance researchers' and writers' efficiency in managing references throughout the research and publication process.
Sleep-Wake Variation In Body Temperature Regulates Tau Secretion And Correlates With Csf And Plasma Tau, Geoffrey Canet, Brendan P. Lucey, Et Al.
Sleep-Wake Variation In Body Temperature Regulates Tau Secretion And Correlates With Csf And Plasma Tau, Geoffrey Canet, Brendan P. Lucey, Et Al.
2020-Current year OA Pubs
Sleep disturbance is bidirectionally associated with an increased risk of Alzheimer's disease and other tauopathies. While the sleep-wake cycle regulates interstitial and cerebrospinal fluid (CSF) tau levels, the underlying mechanisms remain unknown. Understanding these mechanisms is crucial, given the evidence that tau pathology spreads through neuron-to-neuron transfer, involving the secretion and internalization of pathological tau forms. Here, we combined in vitro, in vivo, and clinical methods to reveal a pathway by which changes in body temperature (BT) over the sleep-wake cycle modulate extracellular tau levels. In mice, a higher BT during wakefulness and sleep deprivation increased CSF and plasma tau …
A Randomized, Double-Blind, Placebo-Controlled Trial Of Il-7 In Critically Ill Patients With Covid-19, Manu Shankar-Hari, Kenneth E. Remy, Jane Blood, Andrew H. Walton, Teresa Blood, Richard Hotchkiss, Et Al.
A Randomized, Double-Blind, Placebo-Controlled Trial Of Il-7 In Critically Ill Patients With Covid-19, Manu Shankar-Hari, Kenneth E. Remy, Jane Blood, Andrew H. Walton, Teresa Blood, Richard Hotchkiss, Et Al.
2020-Current year OA Pubs
BACKGROUND: Lymphopenia and failure of lymphocytes to mount an early IFN-γ response correlate with increased mortality in COVID-19. Given the essential role of CD4 helper and CD8 cytotoxic cells in eliminating viral pathogens, this profound loss in lymphocytes may impair patients' ability to eliminate the virus. IL-7 is a pleiotropic cytokine that is obligatory for lymphocyte survival and optimal function.
METHODS: We conducted a prospective, double-blind, randomized, placebo-controlled trial of CYT107, recombinant human IL-7, in 109 critically ill, patients with lymphopenia who have COVID-19. The primary endpoint was to assess CYT107's effect on lymphocyte recovery with secondary clinical endpoints including …
Retinoic Acid Antagonizes Estrogen Signaling To Maintain Adult Uterine Cell Fate, Yan Yin, Meade Haller, Lauren Goldinger, Shivani Bharadwaj, Emily So, Vivian Robles-Pinos, David Chen, Liang Ma
Retinoic Acid Antagonizes Estrogen Signaling To Maintain Adult Uterine Cell Fate, Yan Yin, Meade Haller, Lauren Goldinger, Shivani Bharadwaj, Emily So, Vivian Robles-Pinos, David Chen, Liang Ma
2020-Current year OA Pubs
Classical tissue recombination experiments demonstrate that cell-fate determination along the anterior-posterior axis of the Müllerian duct occurs prior to postnatal day 7 in mice. However, little is known about how these cell types are maintained in adults. In this study, we provide genetic evidence that a balance between antagonistic retinoic acid (RA) and estrogen signaling activity is required to maintain simple columnar cell fate in adult uterine epithelium. Transdifferentiation of simple columnar uterine epithelium into stratified cervicovaginal-like epithelium was observed in three related mouse genetic models, in which RA signaling was perturbed in the postnatal uterus. Single-cell RNA sequencing analysis …
Toxoplasma Chitinase-Like Protein Orchestrates Cyst Wall Glycosylation To Facilitate Effector Export And Cyst Turnover, Yong Fu, Tadakimi Tomita, Louis M Weiss, Christopher M West, L David Sibley
Toxoplasma Chitinase-Like Protein Orchestrates Cyst Wall Glycosylation To Facilitate Effector Export And Cyst Turnover, Yong Fu, Tadakimi Tomita, Louis M Weiss, Christopher M West, L David Sibley
2020-Current year OA Pubs
No abstract provided.
Metabolites And Lipid Species Mediate The Associations Of Adiposity In Childhood And Early Adulthood With Mammographic Breast Density In Premenopausal Women, Kayla R Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T Toriola
Metabolites And Lipid Species Mediate The Associations Of Adiposity In Childhood And Early Adulthood With Mammographic Breast Density In Premenopausal Women, Kayla R Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T Toriola
2020-Current year OA Pubs
BACKGROUND: Mammographic breast density (MBD), a strong predictor of breast cancer, is highly influenced by body mass index (BMI) in childhood and early adulthood, but the mechanisms underlying these associations are not fully understood. Our goal is to identify biomarkers that mediate the associations of BMI at ages 10 and 18 with MBD in premenopausal women.
METHODS: This study consists of 705 premenopausal women who had their screening mammogram at Washington University in St. Louis, MO, and provided a fasting blood sample. Our comprehensive metabolomic and lipidomic profiling yielded complete data for 828 metabolites and 857 lipid species after imputation. …
The Association Between Online Health Information Characteristics And Appropriate Trust In Informational Quality Among Patients With High Cardiovascular Risk, Lim Woei Xian
Student Works (2020-2029)
More patients are turning to the Internet to understand their health and make health decisions. However, the quality of online health information (OHI) is highly variable, and it may contain misinformation. Patients who lack the necessary skills to appraise OHI may trust poor-quality OHI. Thus, this study aims to examine the association between OHI characteristics and appropriate trust in patients with high cardiovascular (CV) risk. This is a secondary analysis from a quantitative cohort study of 270 patients from a primary care clinic in Kuala Lumpur, Malaysia. Patients recorded each OHI encountered over two months in a digital information diary …
Thriving Hives: Processing And Using Beeswax - Candles And Cosmetics, Brynn Meredith, Teresa Hunsaker, Andree' Walker Bravo
Thriving Hives: Processing And Using Beeswax - Candles And Cosmetics, Brynn Meredith, Teresa Hunsaker, Andree' Walker Bravo
All Current Publications
Beeswax is a substance produced by bees for constructing honeycomb in a hive. When raw wax is harvested from the hive, it may be quite dirty and can have many different kinds of debris stuck in it. Because of this, it is important that you clean and process the wax before using it. This fact sheet will teach you how to process the wax that you harvest and provide some suggestions on how you can use it in your home.
Ion Suppression Correction And Normalization For Non-Targeted Metabolomics, Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Alexander Raskind, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-Kin Chan, Rehan Akbani, John N Weinstein, Chris Beecher, Philip L Lorenzi
Ion Suppression Correction And Normalization For Non-Targeted Metabolomics, Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Alexander Raskind, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-Kin Chan, Rehan Akbani, John N Weinstein, Chris Beecher, Philip L Lorenzi
Faculty, Staff and Student Publications
Ion suppression is a major problem in mass spectrometry (MS)-based metabolomics; it can dramatically decrease measurement accuracy, precision, and sensitivity. Here we report a method, the IROA TruQuant Workflow, that uses a stable isotope-labeled internal standard (IROA-IS) library plus companion algorithms to: 1) measure and correct for ion suppression, and 2) perform Dual MSTUS normalization of MS metabolomic data. We evaluate the method across ion chromatography (IC), hydrophilic interaction liquid chromatography (HILIC), and reversed-phase liquid chromatography (RPLC)-MS systems in both positive and negative ionization modes, with clean and unclean ion sources, and across different biological matrices. Across the broad range …
Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial, Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Keith Pereira, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson, Peerless Committees And Investigators
Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial, Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Keith Pereira, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson, Peerless Committees And Investigators
Faculty, Staff and Student Publications
Background: There are a lack of randomized controlled trial data comparing outcomes of different catheter-based interventions for intermediate-risk pulmonary embolism.
Methods: PEERLESS is a prospective, multicenter, randomized controlled trial that enrolled 550 patients with intermediate-risk pulmonary embolism with right ventricular dilatation and additional clinical risk factors randomized 1:1 to treatment with large-bore mechanical thrombectomy (LBMT) or catheter-directed thrombolysis (CDT). The primary end point was a hierarchal win ratio composite of the following (assessed at the sooner of hospital discharge or 7 days after the procedure): (1) all-cause mortality, (2) intracranial hemorrhage, (3) major bleeding, (4) clinical deterioration and/or escalation to …
Diet Therapy Abates Mutant Apc And Kras Effects By Reshaping Plasma Membrane Cholesterol Nanodomains, Eunjoo Kim, Alfredo Erazo-Oliveras, Mónica Muñoz-Vega, Natividad R Fuentes, Michael L Salinas, Roger S Zoh, Bhimanagouda S Patil, Ivan Ivanov, Nancy D Turner, Robert S Chapkin
Diet Therapy Abates Mutant Apc And Kras Effects By Reshaping Plasma Membrane Cholesterol Nanodomains, Eunjoo Kim, Alfredo Erazo-Oliveras, Mónica Muñoz-Vega, Natividad R Fuentes, Michael L Salinas, Roger S Zoh, Bhimanagouda S Patil, Ivan Ivanov, Nancy D Turner, Robert S Chapkin
Faculty, Staff and Student Publications
Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the link between cholesterol homeostasis and mutant APC-KRas-associated colorectal tumorigenesis remains to be established. Thus, we investigated the impact of Apc-Kras on 1) colonocyte plasma membrane cholesterol homeostasis, order, and receptor nanoclustering, 2) colonocyte cell proliferation, and 3) whether these effects are modulated by select membrane active dietaries (MADs). We observed that oncogenic APC-KRas increased membrane order by perturbing cholesterol homeostasis when cell proliferation is upregulated, in part by altering the expression of genes associated with cholesterol influx, export and de …
A Randomized, Double-Blind, Placebo-Controlled Trial Of Il-7 In Critically Ill Patients With Covid-19, Manu Shankar-Hari, Bruno Francois, Kenneth E Remy, Cristina Gutierrez, Stephen Pastores, Robin Jeannet, Andrew H Walton, Reinaldo Salomao, Georg Auzinger, David Striker, Robert S Martin, Nitin J Anand, James Bosanquet, Teresa Blood, Scott Brakenridge, Lyle L Moldawer, Vidula Vachharajani, Cassian Yee, Felipe Dal-Pizzol, Michel Morre, Frederique Berbille, Marcel Van Den Brink, Richard Hotchkiss
A Randomized, Double-Blind, Placebo-Controlled Trial Of Il-7 In Critically Ill Patients With Covid-19, Manu Shankar-Hari, Bruno Francois, Kenneth E Remy, Cristina Gutierrez, Stephen Pastores, Robin Jeannet, Andrew H Walton, Reinaldo Salomao, Georg Auzinger, David Striker, Robert S Martin, Nitin J Anand, James Bosanquet, Teresa Blood, Scott Brakenridge, Lyle L Moldawer, Vidula Vachharajani, Cassian Yee, Felipe Dal-Pizzol, Michel Morre, Frederique Berbille, Marcel Van Den Brink, Richard Hotchkiss
Faculty, Staff and Student Publications
Background: Lymphopenia and failure of lymphocytes to mount an early IFN-γ response correlate with increased mortality in COVID-19. Given the essential role of CD4 helper and CD8 cytotoxic cells in eliminating viral pathogens, this profound loss in lymphocytes may impair patients' ability to eliminate the virus. IL-7 is a pleiotropic cytokine that is obligatory for lymphocyte survival and optimal function.
Methods: We conducted a prospective, double-blind, randomized, placebo-controlled trial of CYT107, recombinant human IL-7, in 109 critically ill, patients with lymphopenia who have COVID-19. The primary endpoint was to assess CYT107's effect on lymphocyte recovery with secondary clinical endpoints including …
Theranostic Nanoemulsions Suppress Macrophage-Mediated Acute Inflammation In Rats, Riddhi Vichare, Yalcin Kulahci, Rebecca Mccallin, Fatih Zor, Fatma Nurefsan Selek, Caitlin Crelli, Michele Herneisey, James M Nichols, Andrew J Shepherd, Vijay S Gorantla, Jelena M Janjic
Theranostic Nanoemulsions Suppress Macrophage-Mediated Acute Inflammation In Rats, Riddhi Vichare, Yalcin Kulahci, Rebecca Mccallin, Fatih Zor, Fatma Nurefsan Selek, Caitlin Crelli, Michele Herneisey, James M Nichols, Andrew J Shepherd, Vijay S Gorantla, Jelena M Janjic
Faculty, Staff and Student Publications
In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. Macrophages are immune cells that contribute to the initiation, maintenance, and resolution of inflammation due to their phenotypic plasticity in response to signals from inflammatory microenvironments. Macrophages infiltrate and polarize toward a pro-inflammatory phenotype (M
Estrogen Receptor-Α Ablation Reverses Muscle Fibrosis And Inguinal Hernias, Jonah J Stulberg, Hong Zhao, Serdar E Bulun
Estrogen Receptor-Α Ablation Reverses Muscle Fibrosis And Inguinal Hernias, Jonah J Stulberg, Hong Zhao, Serdar E Bulun
Faculty, Staff and Student Publications
Fibrosis of the lower abdominal muscle (LAM) contributes to muscle weakening and inguinal hernia formation, an ailment that affects a noteworthy 50% of men by age 75 and necessitates surgical correction as the singular therapy. Despite its prevalence, the mechanisms driving LAM fibrosis and hernia development remain poorly understood. Using a humanized mouse model that replicates the elevated skeletal muscle tissue estrogen concentrations seen in aging men, we identified estrogen receptor-α (ESR1) as a key driver of LAM fibroblast proliferation, extracellular matrix deposition, and hernia formation. Fibroblast-specific ESR1 ablation effectively prevented muscle fibrosis and herniation, while pharmacological ESR1 inhibition with …
What Podcasting Taught Me About Writing: Revelations From Behind The Mic, Alicja Syska
What Podcasting Taught Me About Writing: Revelations From Behind The Mic, Alicja Syska
School of Law, Humanities and Social Sciences
This chapter explores the transformative impact of podcasting on writing, drawing on the author’s experimentations with technology during the pandemic when new communication methods with students became necessary. The analysis reveals a series of lessons and revelations applicable to both teaching and scholarly development. Key insights include: the significance of voice and audience in writing; developing effective writing strategies; shifting focus from product to process; navigating the permanence of written work; addressing vulnerability in self-expression; and cultivating resilience and consistency in writing practice. Through reflexive analysis, the chapter demonstrates how these revelations at the intersection of podcasting and writing can …
The Influence Of Peer-To-Peer Accommodation Platforms’ Green Marketing On Consumers’ Pro-Environmental Behavioural Intention, Songshan (Sam) Huang, Xuequn Wang, Hua Qu
The Influence Of Peer-To-Peer Accommodation Platforms’ Green Marketing On Consumers’ Pro-Environmental Behavioural Intention, Songshan (Sam) Huang, Xuequn Wang, Hua Qu
Research outputs 2022 to 2026
Purpose: This study aims to examine the impact of peer-to-peer (P2P) accommodation platforms’ green marketing on consumers’ pro-environmental behavioural intention through the mediation of consumer trust and engagement, following the social influence theory and the stimulus–organism–response model. Design/methodology/approach: A questionnaire survey was designed to collect data from American P2P accommodation consumers. Data collection was conducted through an outsourced survey company. Partial least squares structural equation modelling was used to analyse the data. Findings: The study reveals that P2P accommodation platforms’ green marketing orientation was positively associated with consumer trust in the platform and consumer engagement with the platform. Both consumer …
Discerning What Power Is For: The Spirit’S Dynamic Work In History Will Always Rhyme With What God Has Manifested In Jesus, James K.A. Smith
Discerning What Power Is For: The Spirit’S Dynamic Work In History Will Always Rhyme With What God Has Manifested In Jesus, James K.A. Smith
University Faculty Publications and Creative Works
It was the 90s, as the kids say. The Pentecostal church where we worshipped in Stratford, Ontario, was swept up in the revival rippling from Airport Vineyard in nearby Toronto. News of strange and miraculous manifestations spread around the world. But the reports that struck me were testimonies about emotional healing — gut-level emotional restoration that overcame years of pain and trauma. I can still picture my friend, Michael, weeping as he bore witness to the work the Spirit had done in his heart and soul. Whatever one wanted to make of the laughing and barking(!) and trance-like states people …
Sustaining Diversity, Equity, And Inclusion Through Transformational Leadership In Behavioral Health Management, Ndubuisi Christopher Egunetugo
Sustaining Diversity, Equity, And Inclusion Through Transformational Leadership In Behavioral Health Management, Ndubuisi Christopher Egunetugo
Walden Dissertations and Doctoral Studies
This case study examines the challenges of Diversity, Equity, and Inclusion (DEI) within an organization, emphasizing systemic biases, workforce diversity, and the necessity of culturally competent care. The Behavioral Health Organization in the southern United States faces significant DEI challenges due to its diverse clientele, workforce, and various stakeholders. Transformational leadership, marked by visionary thinking and actionable initiatives, is crucial for sustaining DEI efforts and addressing disparities in service access, care quality, management practices, and treatment outcomes. The Baldrige Framework of Excellence is employed as a systematic method to embed DEI principles across organizational operations, facilitated by transformational leadership to …
Police Culture Influence On Mental Health Of Federal Law Enforcement Officers, Ania Amat
Police Culture Influence On Mental Health Of Federal Law Enforcement Officers, Ania Amat
Walden Dissertations and Doctoral Studies
Occupational stressors are inherent in police work. Left unmitigated, these stressors may have deleterious effects on officers’ overall health. Police agencies throughout the country offer organizational resilience programs to aid officers navigate stressors. A constraint keeping officers from seeking mental health wellness are the unspoken social norms of police culture. Police culture stigmatizes mental health seeking behaviors, deterring officers from accessing organizational resilience programs. The purpose of this study was to understand the perceptions and lived experiences of federal law enforcement officers regarding mental health-seeking behaviors and the influence of the police culture. Study participants included 16 federal law enforcement …