Digital Commons Network^™

Neutralizing Antibody Immune Correlates For A Recombinant Protein Vaccine In The Covail Trial, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G Rouphael, Angela R Branche, David J Diemert, Ann R Falsey, Cecilia Losada, Lindsey R Baden, Sharon E Frey, Jennifer A Whitaker, Susan J Little, Satoshi Kamidani, Emmanuel B Walter, Richard M Novak, Richard Rupp, Lisa A Jackson, Chenchen Yu, Craig A Magaret, Cindy Molitor, Bhavesh Borate, Tara M Babu, Angelica C Kottkamp, Anne F Luetkemeyer, Lilly C Immergluck, Rachel M Presti, Martín Bäcker, Patricia L Winokur, Siham M Mahgoub, Paul A Goepfert, Dahlene N Fusco, Robert L Atmar, Christine M Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K Makhene, Seema U Nayak, Paul C Roberts, Dean Follmann, Peter B Gilbert

Faculty, Staff and Students Publications

For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

Acute Mecp2 Loss In Adult Mice Reveals Transcriptional And Chromatin Changes That Precede Neurological Dysfunction And Inform Pathogenesis, Harini P Tirumala, Mark A Durham, Alexander J Trostle, Michelle Dias, Yingyao Shao, Hu Chen, Wei Wang, Hari Krishna Yalamanchili, Ying-Wooi Wan, Laura A Banaszynski, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett syndrome, a severe childhood neurological disorder. MeCP2 is a well-established transcriptional repressor, yet upon its loss, hundreds of genes are dysregulated in both directions. To understand what drives such dysregulation, we deleted Mecp2 in adult mice, circumventing developmental contributions and secondary pathogenesis. We performed time series transcriptional, chromatin, and phenotypic analyses of the hippocampus to determine the immediate consequences of MeCP2 loss and the cascade of pathogenesis. We find that loss of MeCP2 causes immediate and bidirectional progressive dysregulation of the transcriptome. To understand what drives gene downregulation, we …

Ddo-Adjuvanted Influenza A Virus Nucleoprotein Mrna Vaccine Induces Robust Humoral And Cellular Type 1 Immune Responses And Protects Mice From Challenge, Victoria Gnazzo, Hanaa Saleh, Ítalo A Castro, Adrianus C M Boon, Amelia K. Pinto, James D Brien, Carolina B López

2020-Current year OA Pubs

A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8

Hyperkalemia And Pneumonia: A Retrospective Study On Mortality Outcomes In Southwest Missouri, Sukhmanjit Kaur, Alexandra Belohlavek, Melissa Bryan, Celine Nguyen, Scott A. Andelin, Nova Beyersdorfer, Kerry Johnson, John Paulson

Student Publications

Background: Pneumonia stands as a widely known contributor to hospitalization and mortality among adults in the United States. Meanwhile, disruptions in potassium homeostasis such as hyperkalemia may have an impact on in-patient mortality. This study seeks to examine the presence of hyperkalemia and its association with in-patient mortality among pneumonia patients.

Methods: Electronic medical records were used to perform a retrospective observational cohort study in Southwest Missouri patients admitted to the hospital with pneumonia and/or hyperkalemia. Patients were divided into three samples: patients with pneumonia and hyperkalemia (P1), pneumonia without hyperkalemia (P2), and hyperkalemia without pneumonia (P3). The goal was …

Socioeconomic And Geographic Differences In Mammography Trends Following The 2009 Uspstf Policy Update, Jason Semprini, Loren Saulsberry, Olufunmilayo Olopade

Public Health

Importance In 2024, the US Preventive Services Task Force (USPSTF) reversed a 2009 policy recommending only females aged 50 to 74 years complete a biennial mammogram. Understanding whether females facing heterogeneous breast cancer risks responded to the 2009 guidance may illuminate how they may respond to the latest policy update.

Objective To evaluate whether the 2009 policy was associated with changes in mammography screening in females no longer recommended to complete a biennial mammogram and whether these changes varied by factors associated with breast cancer risk.

Design, Setting, and Participants The difference-in-differences design compared biennial mammogram trends in the exposed …

Fault Diagnosis And Fault Tolerant Structure For Multilevel Inverters Using Machine Learning Techniques, Sudha V

Theses and Dissertations

A paradigm shift towards electric drives in domestic and industrial sectors has significantly increased the use of multilevel inverters (MLI). MLIs are constructed using more semiconductor devices, which hinders safety and reliability. Literature states 31.2% of failures in MLIs are due to semiconductor devices. Hence, there is a need for fault detection and tolerant mechanisms to ensure the safety and reliability of MLIs.

MLIs like Cascaded H-bridge(CHB) and Packed U cell(PUC) are mostly preferred due to low harmonic distortion, which is considered in this work. The complexity associated with fault diagnosis with more components in MLIs is addressed by machine …

Clarice Smith Davis

African American Funeral Programs

No abstract provided.

The Parthenon, February 05, 2025, Sarah Davis, Baylee Parsons, Kaitlyn Fleming, Nate Harrah, Caden Adkins, Scott Price, Ella Bumgardner, Wade Sullivan

The Parthenon

No abstract provided.

Statement To The Board Of Trustees, Fall 2024, Shannon Bellum

University Senate - Board of Trustees Statements

Reports to the University Board of Trustees by the Senate President - President Bellum's Board of Trustees Address (Fall 2024)

Rectus Abdominis Repair Compared To Posterior Wall Mesh Reinforcement In Athletes With Sportsman's Hernia: A Systematic Review, Jonathan Mckeeman, Benjamin Johnson, Jessica C. Rivera

School of Medicine Faculty Publications

Athletic pubalgia is a relatively uncommon injury that is not fully understood. There are few high-level studies comparing treatments of athletic pubalgia, and this investigation seeks to utilize original articles to compare two common techniques for treatment of athletic pubalgia. The purpose of this study is to compare two prominent procedures, i.e., rectus abdominus repair and posterior wall reinforcement, through a systematic review. Inclusion/exclusion criteria were identified and then applied to search strategies in PubMed and MEDLINE. Two reviewers screened articles based on the agreed-upon criteria in a primary screen of titles and abstracts and a secondary screen of full-text …

Elephant Management In Southern Africa, Andrew N. Rowan

WellBeing News

On January 27, 2025, the South African Department of Forestry, Fisheries and Environment (DFFE) released the draft National Elephant Heritage Strategy for public comment, outlining objectives for managing and conserving South Africa's elephant population. With over 44,000 elephants in the country—31,000 of which are in Kruger National Park—debates over elephant population control, including culling and alternative management strategies, continue to evolve as experts assess their ecological impact and biodiversity role.

Dog Population In The Usa, Andrew N. Rowan

WellBeing News

Dog population studies reveal that approximately 60% of the world's dogs live in human homes, contrary to previous claims that most are free-roaming. Recent analyses also show a strong correlation between dog populations and human density, providing valuable insights for animal shelters, pet policies, and urban planning.

Is The World Running Out Of Fresh Water?, Andrew N. Rowan

WellBeing News

Freshwater scarcity is becoming a global crisis, with record-low river flows, severe droughts, and escalating climate change impacts disrupting water resources worldwide. Reports from the World Meteorological Organization and the World Economic Forum highlight urgent concerns, emphasizing the need for immediate action to safeguard the planet’s dwindling freshwater supply.

Enhancing Care: Child Protective Service Workers’ Perspectives And Experiences Of Serving Children With Disabilities, Meekyung Han, Celia Rocio Murillo Lechuga, Gaby Solis

Faculty Research, Scholarly, and Creative Activity

Children with disabilities (CWD) are overrepresented in the child welfare system (CWS), yet limited research exists on how child protective service (CPS) workers respond. This exploratory qualitative study conducted semi-structured individual interviews with 12 CPS workers in Northern California to explore their experiences. Thematic analysis identified five key themes: contributors to maltreatment, challenges of working with CWD, the influence of personal/professional experience, collaboration with disability experts, and the need for training. Findings suggest that disability-focused training in the graduate Title IV-E program and ongoing professional training can enhance CPS workers’ competency and strengthen interactions with CWD, leading to better outcomes.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Evaluation Of Institutional Prophylactic Open Fracture Antibiotic Guidelines On Infection Development., Lillian D. Gates, Emily N. Gray, Kaili Donahue, Alexander Aucoin, Sarthak Parikh, Hung-Wen Yeh, Robert B. Goodwin, Amanda Hembree

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Open fracture wounds are associated with a high risk of infection, though the outcomes are dependent on the fracture location, prophylactic antibiotics utilized, and time to antibiotic intervention. Although several institutions have provided guidelines for appropriate prophylaxis in open fractures, there is currently no consensus on antibiotic selection and duration. Reducing inappropriate prophylactic antibiotic use for open bone fractures is a potential stewardship opportunity within pharmacy departments.

OBJECTIVES:  This study aimed to determine the rates of open fracture-related infections and antibiotic ordering adherence to institutional guidelines. Patients were grouped based on the time of diagnosis relative to the institutional …

Quantum Phase Transition Of Non-Hermitian Systems Using Variational Quantum Techniques, James Hancock, Matthew Craven, Craig Mcneile, Davide Vadacchino

School of Engineering, Computing and Mathematics

The motivation for studying non-hermitian systems and the role of PT-symmetry is discussed. We investigate the use of a quantum algorithm to find the eigenvalues and eigenvectors of non-Hermitian Hamiltonians, with applications to quantum phase transitions. We use a recently proposed variational algorithm. The systems studied are the transverse Ising model with both a purely real and a purely complex transverse field.

Plymfit Pilot -A Study To Investigate The Feasibility Of Wrist-Worn Smartwatch Use In Perioperative Care, Alex Hunter

Faculty of Health Datasets

Extended data for a protocol manuscript submission.

A Critical Appraisal Of The Evidence On Racial Disproportionality In Special Education, Rachel E. Fish, Kenneth Shores, Joào M. Souto Maior

Education and Child Study: Faculty Publications

This essay provides a two-pronged critical assessment of a subset of the literature on racial disproportionality in special education: that which aims to estimate racial disparities among otherwise similar children. This body of research has shown that Black students are less likely than comparable White students to receive special education, and has been interpreted by many to mean that current policies meant to reduce Black over-representation may be exacerbating inequality. Our essay argues that this subset of research has fundamental limitations in its covariate adjustment practices and its data quality, making “under-representation” findings questionable. We argue that caution and further …

The Bg News February 5, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 5, 2025. Volume 104-Issue 16.

Study Explores Compound's Potential To Enhance Thc For Pain Treatment, Clara Turnage

University of Mississippi News

OXFORD, Miss. – University of Mississippi researchers have discovered how a compound found in cannabis might be used to mitigate the negative effects of THC, a psychoactive compound in the plant.

Chief Paul Dean Retires After 35 Years At Unh, Emma Kostyun

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Men’S Hockey Went 1-1 Against University Of Vermont In Weekend Series, Melissa Gold

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

A Review Of Artificial Intelligence, Algorithms, And Robots Through The Lens Of Stakeholder Theory, Michael J. Matthews, Su Runkun, Lindsey Yonish, Shawn Mcclean, Joel Koopman, Kai Chi Yam

Management Faculty Publications

With the arrival of the Fourth Industrial Revolution, intelligent machines are affecting the daily lives of multiple organizational stakeholders. However, despite the continued expansion of intelligent machines in society, management scholarship has generally lagged, and current frameworks are under-equipped to offer meaningful guidance regarding the intersection of intelligent machines and organizations. We address this issue via a multidisciplinary review and a novel framework of intelligent machines and value creation. First, we discuss the characteristics of intelligent machines (i.e., autonomy, learning, inscrutability, and materiality) and how variation in these characteristics impacts their affordances and, subsequently, the value offered to stakeholders. We …

Supplementary Material 10: Nyquist Plots, Control Design, Raúl Ordóñez

Resources for Undergraduate and Graduate Courses in Systems and Controls

Lecture supplement for the course Control Systems (ECE 415) in the University of Dayton School of Engineering Department of Electrical and Computer Engineering, taught by Raúl Ordóñez, PhD, Professor. The course is a study of mathematical models for control systems and analysis of performance characteristics and stability. Design topics include pole placement, root locus, and frequency domain techniques.

Supplementary Material 07: Root Locus, Raúl Ordóñez

Resources for Undergraduate and Graduate Courses in Systems and Controls

Lecture supplement for the course Control Systems (ECE 415) in the University of Dayton School of Engineering Department of Electrical and Computer Engineering, taught by Raúl Ordóñez, PhD, Professor. The course is a study of mathematical models for control systems and analysis of performance characteristics and stability. Design topics include pole placement, root locus, and frequency domain techniques.

Annual Financial Report Sullivan County, Tennessee For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Reforming Grading At The University Of Mississippi, Josh Eyler

Events

We are currently in the midst of one of the most fruitful, effective periods of grading reform in our country's history, both in K-12 and in higher ed. At many institutions, including our own, faculty are experimenting with a variety of alternative grading strategies and are having success, but many are eager to see more widespread change at the department and institutional levels. This session provides attendees with research-based tools for advancing grading reform initiatives at scale and provides participants with strategies for moving the conversation forward. Lunch will be provided for registered participants.

Oregon State Rank Assessment For Cascade Rockcress (Boechera Cascadensis), Gabriel E. Campbell, Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for Cascade rockcress (Boechera cascadensis) using NatureServe methodology, 2025.

Autonomy Now?: Is It Time To Start Integrating (Autonomous) Urban Air Mobility Vehicles Into The National Airspace System?, Robert Notari

Texas A&M Law Review

Urban Air Mobility has the potential to radically change the fundamental nature of transportation within the United States. But challenges abound—from critical shortages of air traffic controllers and pilots and gaps in key technologies and infrastructure to the negative public perception of autonomous vehicles. FAA and industry, employing an evolutionary and safety-focused approach, can overcome these challenges through a combination of creative regulation, targeted technology development, and leveraging lessons learned through the FAA’s drone integration efforts. However, if drone integration is any guide, industry should be prepared for a long integration timeline, with autonomy still on the horizon.