Digital Commons Network^™

Examination Of Protective Mucosal Immune Responses To Viral Sexually Transmitted Infections, Aisha Lee

Arts & Sciences Graduate Student Theses and Dissertations

Sexually transmitted infections (STI) are a prominent global health issue that affect the sexual and reproductive health of billions worldwide. Viral STIs present a particular challenge due to limited availability of treatment options and their frequent establishment of lifelong infection. One of the most common viral STIs is genital herpes, a recurrent ulcerative disease caused by chronic infection with the human alphaherpesviruses, HSV-1 or HSV-2. Women are particularly susceptible to morbidities of infection ranging from increased risk of HIV-1 acquisition to vertical transfer to neonates, for whom infection can be fatal. Previous efforts to develop a prophylactic vaccine for genital …

Bridging The Gap: Analyzing Volunteerism Barriers To The International Humanitarian Ngos In Egypt, Heba Fouad

Theses and Dissertations

In Egypt, volunteerism, within international humanitarian non-governmental organizations (NGOs), functions in distinctive characteristics influenced by, among other things, cultural, educational, and economic factors. NGOs face challenges and obstacles in attracting motivated volunteers, engaging and training volunteers, as well as managing the staff-volunteers relationship, and implementing adequate human resources (HR) policies and strategies. In this context, this thesis seeks to bridge the knowledge gap of volunteerism challenges in Egypt, delving deep into understanding the barriers existing within the international humanitarian NGOs that directly and indirectly influence its volunteer engagement levels. The thesis also aims to understand the successful implementation of policies …

Front Matter, Natural Resources Journal Nrj

Natural Resources Journal

No abstract provided.

Introduction, Lauren Hewitt, Danielle Lopez

Natural Resources Journal

No abstract provided.

The Case For Nuclear: How A Simple Amendment To Purpa Could Invigorate The Market For Advanced Nuclear And Help The United States Decarbonize Faster Than Ever, Nathan Wise

Natural Resources Journal

The Public Utility Regulatory Policies Act of 1978 (PURPA) was passed in the 1970s to advance the United States’ energy independence through the encouragement of energy conservation, energy efficiency, small power production, and competition within the energy industry. Administered by the Federal Energy Regulatory Commission (FERC), it allows energy producers whose facilities qualify under its criteria to buy and sell electricity to larger-scale energy producers at rates set by state agencies. Today, PURPA and FERC’s accompanying regulations do not allow for facilities that run on nuclear fuel to qualify as “small power production facilities.” Though these facilities could still qualify …

A Horse Named “Stream Depletion Theory”: The History And Negotiation Of The Upper Colorado River Basin Compact, Eric Kuhn, Katherine H. Tara, John Fleck

Natural Resources Journal

The 1922 Compact only apportions the beneficial consumptive use of the river system’s waters between two geographic sub-basins, an Upper Basin and a Lower Basin. The 1922 Compact negotiators left the task of allocating water to individual states to future negotiations among the sub-basins. The five states with Upper Basin lands completed this task in 1948. The negotiations of the Upper Colorado River Basin Compact provide significant context for understanding the Law of the River, particularly considering ongoing Post-2026 Colorado River Operations discussions. This article examines the dynamics between the states, the role of the United States, the debate over …

Unsustainable: Amazon, Warehousing, And The Politics Of Exploitation By Juliann Emmons Allison & Ellen Reese, Elise Payette

Natural Resources Journal

No abstract provided.

Dark Skies: Places, Practices, Communities Edited By Nick Dunn & Tim Edensor, Stella Rose-Wyatt

Natural Resources Journal

No abstract provided.

The Pulse - February 6, 2025, Unm Hsc Marketing & Communications

The Pulse

Weekly newsletter of the UNM Health Sciences Center.

Same Data, Different Analysts: Variation In Effect Sizes Due To Analytical Decisions In Ecology And Evolutionary Biology, Elliot Gould, Hannah S. Fraser, Timothy H. Parker, Shinichi Nakagawa, Simon C. Griffith, Peter A. Vesk, Fiona Fidler, Daniel G. Hamilton, Robin N. Abbey-Lee, Andrea Contina

School of Integrative Biological & Chemical Sciences Faculty Publications

Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explanation for variation among results is differences among researchers in the decisions they make regarding statistical analyses. A growing array of studies has explored this analytical variability in different fields and has found substantial variability among results despite analysts having the same data and research question. Many of these studies have been in the social sciences, but one small “many analyst” study found similar variability in ecology. We expanded the scope …

Sc A, Extension

Advisory Council

No abstract provided.

Field And Campus: Fall 2024, Allison Gillingham

NYLS Community News

No abstract provided.

Faculty Highlights: Fall 2024, New York Law School

NYLS Community News

No abstract provided.

Heterogeneous Clinical Phenotypes Of Sporadic Early-Onset Alzheimer's Disease: A Neuropsychological Data-Driven Approach, Deepti Putcha, Erik Musiek, Kyle Womack, Et Al.

2020-Current year OA Pubs

BACKGROUND: The clinical presentations of early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease are distinct, with EOAD having a more aggressive disease course with greater heterogeneity. Recent publications from the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) described EOAD as predominantly amnestic, though this phenotypic description was based solely on clinical judgment. To better understand the phenotypic range of EOAD presentation, we applied a neuropsychological data-driven method to subtype the LEADS cohort.

METHODS: Neuropsychological test performance from 169 amyloid-positive EOAD participants were analyzed. Education-corrected normative comparisons were made using a sample of 98 cognitively normal participants. Comparing the relative levels of …

February 6, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

February 6, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Brother Clarence Thompson, Sr.

African American Funeral Programs

Funeral program for Clarence Thompson. Service was held on February 6, 2025 in Boston, Massachusetts.

Eng 2504g-001 Film And Literature, Robert Martinez

Fall 2024

No abstract provided.

Winter Hay-Feeding Effects On Soil Properties In A Rotationally Grazed Pasture System In The Ozark Highlands, Larry Berry, Kristofor R. Brye, Andrew Sharpley, Ron Morrow, Dirk Phillip, Tim A. Glover, James M. Burke, Mike B. Daniels

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Soil nutrient management for pastures in Arkansas often ignores nutrients applied from feeding hay to cattle. Discounting nutrient contributions from hay may increase the likelihood of unnecessary fertilizer over-application. This study evaluated the effects of unrolling bales (unroll fed, UF) and using a ring feeder (ring fed, RF), compared to an unamended control, on changes in soil properties in the top 4 inches in a rotationally grazed, beef [red angus (Bos taurus)] pasture on silt-loam soils in northwest Arkansas. Forty-six cow-calf pairs were fed hay at 6.6 tons acre(-1) year(-1) (14.8 Mg ha(-1) year(-1); dry-weight basis) from December to February …

Differentiating Between Renal Medullary And Clear Cell Renal Carcinoma With A Machine Learning Radiomics Approach, Rahim Jiwani, Koustav Pal, Iwan Paolucci, Bruno Odisio, Kristy Brock, Daniel D Shapiro, Rahul A Sheth

Faculty, Staff and Student Publications

Background: The objective of this study was to develop and validate a radiomics-based machine learning (ML) model to differentiate between renal medullary carcinoma (RMC) and clear cell renal carcinoma (ccRCC).

Methods: This retrospective Institutional Review Board -approved study analyzed CT images and clinical data from patients with RMC (n = 87) and ccRCC (n = 93). Patients without contrast-enhanced CT scans obtained before nephrectomy were excluded. A standard volumetric software package (MIM 7.1.4, MIM Software Inc.) was used for contouring, after which 949 radiomics features were extracted with PyRadiomics 3.1.0. Radiomics analysis was then performed with RadAR for differential radiomics …

Proceedings Of The 1st Biannual Bridging The Gaps In Lung Cancer Conference, Narjust Florez, Sandip P Patel, Heather Wakelee, Lyudmila Bazhenova, Erminia Massarelli, Brendon Stiles, Jyoti Malhotra, Shirish M Gadgeel, Jorge J Nieva, Michelle Afkhami, Fred R Hirsch, Matthew Gubens, Tina Cascone, Benjamin Levy, Joshua Sabari, Hatim Husain, Patrick C Ma, Leah M Backhus, Puneeth Iyengar, Percy Lee, Russell Miller, Jacob Sands, Edward Kim

Faculty, Staff and Student Publications

Lung cancer is the leading cause of cancer death in the US and globally. The mortality from lung cancer has been declining, due to a reduction in incidence and advances in treatment. Although recent success in developing targeted and immunotherapies for lung cancer has benefitted patients, it has also expanded the complexity of potential treatment options for health care providers. To aid in reducing such complexity, experts in oncology convened a conference (Bridging the Gaps in Lung Cancer) to identify current knowledge gaps and controversies in the diagnosis, treatment, and outcomes of various lung cancer scenarios, as described here. Such …

Preclinical Efficacy Of Cdk7 Inhibitor-Based Combinations Against Myeloproliferative Neoplasms Transformed To Aml, Warren Fiskus, Christopher P Mill, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Christine E Birdwell, Kaberi Das, Hanxi Hou, Taghi Manshouri, Antrix Jain, Anna Malovannaya, Kevin Philip, Noor Alhamadani, Alicia Matthews, Katie Lin, Lauren B Flores, Sanam Loghavi, Courtney Dinardo, Xiaoping Su, Raajit K Rampal, Kapil N Bhalla

Faculty, Staff and Student Publications

Rising blast percentage or secondary acute myeloid leukemia (sAML) transformation in myeloproliferative neoplasms (MPNs) leads to JAK1/2 inhibitor (JAKi) therapy resistance and poor survival. Here, we demonstrate that treatment with the CDK7 inhibitor (CDK7i) SY-5609 depletes phenotypically characterized post-MPN sAML stem/progenitor cells. In cultured post-MPN sAML SET2, HEL and patient-derived (PD) post-MPN sAML cells, SY-5609 treatment inhibited growth and induced lethality while sparing normal cells. RNA-sequencing analysis after SY-5609 treatment reduced mRNA expression of MYC, MYB, CDK4/6, PIM1, and CCND1 but increased expression of CDKN1A and BCL2L1. Mass spectrometry of SY-5609-treated MPN-sAML cells also reduced c-Myc, c-Myb, PIM1, and CDK4/6 …

Oncogenic Kras Mutations Confer A Unique Mechanotransduction Response To Peristalsis In Colorectal Cancer Cells, Abigail J Clevenger, Claudia A Collier, John Paul M Gorley, Sarah Colijn, Maygan K Mcfarlin, Scott Kopetz, Shreya A Raghavan

Faculty, Staff and Student Publications

Colorectal cancer tumors start as polyps on the inner lining of the colorectum, in which they are exposed to the mechanics of peristalsis. Our previous work leveraged a custom-built peristalsis bioreactor to demonstrate that colonic peristalsis led to cancer stem cell enrichment in colorectal cancer cells. However, this malignant mechanotransductive response was confined to select colorectal cancer lines that harbored an oncogenic mutation in the Kirsten rat sarcoma virus (KRAS) gene. In this study, we explored the involvement of activating KRAS mutations on peristalsis-associated mechanotransduction in colorectal cancer. Peristalsis enriched cancer stem cell marker Leucine-rich repeat-containing G protein-coupled receptor 5 …

Differences In Provider Beliefs And Delivery Of The 5as For Cigarette And Non-Cigarette Tobacco Use Between Two Types Of Healthcare Centers Serving Rural And/Or Medically Underserved Areas Of Texas, Us, Ammar D Siddiqi, Brian J Carter, Maggie Britton, Tzuan A Chen, Isabel Martinez Leal, Asfand B Moosa, Teresa Williams, Kathleen Casey, Hector Sanchez, Lorraine R Reitzel

Faculty, Staff and Student Publications

Background/objectives: Rural populations in the US bear a disproportionate burden of cancer mortality, which may be partly due to their elevated tobacco use and the limited receipt of tobacco use interventions in rural healthcare settings. Here, we examine providers' use of the 5As (Ask, Advise, Assess, Assist, and Arrange), a brief tobacco cessation intervention, with their patients to assess intervention gaps.

Methods: Provider practices in substance use treatment centers (SUTCs) and medical healthcare centers (MHCs), each serving rural and/or medically underserved areas (MUAs) of Texas, were compared. In total, 347 providers from 10 SUTCs (n = 174) and 9 …

Perspectives Of Juvenile Violence Prevention Programs, Tamlar D. Walton

Walden Dissertations and Doctoral Studies

The increase in violent behavior among individuals aged 12 to 19 prompted a nonprofit organization to consider adopting a more proactive approach to reduce such violence in the community while also expanding the range of services offered to address this concern. The organization leaders recognized the necessity of improving their knowledge in this area, prompting them to enlist the services of a research consultant who utilized a generic qualitative research method to explore juvenile violence prevention programs. This professional administrative study examined the experiences and perspectives of public servants who engaged with juvenile offenders, focusing on the influence of their …

Perinatal Mental Health Providers’ Perceptions Of Medicaid Expansion, Chelsea Desiree Walls

Walden Dissertations and Doctoral Studies

Many women will experience a mood disorder at some point during the perinatal period, which begins at conception and extends to at least the 1st birthday of their child. With the expansion of Medicaid in the U.S. state of North Carolina in 2023, many new women of childbearing age have coverage that includes mental health services. However, despite this huge surge in newly insured women there is no notable increase in the number of mental health providers (social workers, clinical mental health counselors, etc.) in the state who accept Medicaid. The purpose of this study was to determine what service …

Relationship Between Daily Hassles In Different Domains And Later Anxiety And Depression With A Moderator Of Rejection Sensitivity Among Adolescents, Ashley Vasquez Gonzalez

Walden Dissertations and Doctoral Studies

Exposure to stress can affect youths’ well-being; however, there was a need for research on how different types of stress or daily hassles are associated with emotional adjustment. Daily hassles common in adolescence, can occur in multiple domains including school, family, peer, appearance, and sports. Being sensitive to rejection may strengthen associations with emotional adjustment problems, especially for hassles in interpersonal domains. The purpose of this quantitative correlational study was to examine the associations between daily hassles in different domains and later anxiety and depression and how nervous and angry rejection sensitivity moderated those relationships. This study was based on …

Exploring The Impact Of Sufficient Childcare On Recruitment And Retention Of African American Women In Law Enforcement, Jo Anne Wallace

Walden Dissertations and Doctoral Studies

Although African American women have made progress in multiple fields and careers, they remain underrepresented in the field of law enforcement. There has been a lot of research about women in law enforcement, but there has been little research to show the impact of lack of sufficient childcare on the recruitment and retention of African American women in law enforcement. The purpose of this qualitative phenomenological study was to explore the lived experiences of African American female police applicants, recruits, and veteran officers and their perception of challenges and barriers in recruitment and retention when it comes to the lack …

Aviation Maintenance Technicians’ Perceptions Of Safety Management System Implementation At Maintenance, Repair, And Overhaul Facilities, Stanley Matthew Losiewicz

Walden Dissertations and Doctoral Studies

A safety management system (SMS) is challenging for an aviation maintenance facility and even more significant for the aviation maintenance technicians (AMTs) entrusted to perform the work due to organizational, methodological, and consistency issues. The incorporation of an SMS is new in the United States for maintenance, repair, and overhaul (MRO) facilities that operate under the Code of Federal Regulations Part 145. AMTs constitute the bulk of the workers in an MRO. By default, a safety culture and safety consciousness existed in MROs prior to an SMS, and this study was conducted to understand the perceptions of the AMTs in …

Staff Education To Incorporate Mental Health Screenings In Family Practice, Dani Achi

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project implemented a staff education initiative to integrate mental health screenings into family practice settings, addressing inconsistent screening practices that contribute to unmet patient needs and the exacerbation of mental health conditions. Guided by the question of whether education on the GAD-7 screening tool improves staff knowledge and competence in identifying generalized anxiety disorder, the project introduced both the GAD-7 and PHQ-9 tools to seven health care providers. Preintervention assessments revealed a baseline knowledge level of 47.5% correct responses, which increased to 91% postintervention. The initiative not only enhanced provider competence and satisfaction but also …