Digital Commons Network^™

Otolaryngology Practitioner Attitudes Toward Human Papillomavirus Vaccination In Academic Otolaryngology Clinics, Dante J. Merlino, Katelyn S. Rourk, George B. Sankar, Adam J. Luginbuhl, Brian J. Boyce, Michelle M. Chen, Eric M. Dowling, Michael C. Topf, Raymond L. Chai, Karthik Rajasekaran, Eric J. Moore, Daniel L. Price, George Saieed, Kathryn M. Van Abel

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Despite the existence of a highly effective and safe vaccine against human papillomavirus (HPV) infection, vaccination rates remain low. The most prevalent HPV-associated malignancy in the United States is oropharyngeal cancer, but otolaryngology practitioners do not offer the HPV vaccine, and their feelings around offering HPV vaccination have not been evaluated. A 43-question survey, including a twelve-question knowledge quiz, was sent to otolaryngology practitioners at seven academic institutions. Twelve questions comprised a knowledge quiz testing practitioner understanding of HPV, while the remainder of the questions evaluated comfort with and likelihood of recommending vaccination. Of the 442 practitioners who were sent …

Re: Silver Bow Creek Butte Area Npl Site 4th Quarter 2024 Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Data Report. Consent Decree- Civil Action No. Cv 89- 039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Regression Modeling Of Cumulative Incidence Function For Left-Truncated Right-Censored Competing Risks Data: A Modified Pseudo-Observation Approach, Rong Rong, Jing Ning, Hong Zhu

Faculty, Staff and Student Publications

Statistical methods have been developed for regression modeling of the cumulative incidence function (CIF) given left-truncated right-censored competing risks data. Nevertheless, existing methods typically involve complicated weighted estimating equations or nonparametric conditional likelihood function and often require a restrictive assumption that censoring and/or truncation times are independent of failure time. The pseudo-observation (PO) approach has been used in regression modeling of CIF for right-censored competing risks data under covariate-independent censoring or covariate-dependent censoring. We extend this approach to left-truncated right-censored competing risks data and propose to directly model the CIF based on POs, under general truncation and censoring mechanisms. We …

“I Will Never Be Out With This Campus”: Impacts Of Lgbtq+ Microaggressions, Clara E. O'Brien

Clinical Psychology Dissertations

This study reports on the results of a mixed method analysis on the experiences of LGBTQIA+ microaggressions experienced at a non-affirming Free Methodist affiliated university campus. The impact of religiously based LGBTQIA+ microaggressions on religion-sexuality conflict and, in turn strength of religious faith and sexual identity distress was examined. Further, I explored whether racial identity moderated the relationship between religiously based LGBTQIA+ microaggressions and sexual identity distress. Participants (N = 248) included students, faculty, and staff identifying as LGBTQIA+. Quantitative results suggested that that greater religion-sexuality conflict was associated with greater strength of religious faith (B = .239, …

Penggunaan Kredit Sindikasi Untuk Pendanaan Proyek Infrastruktur Ketenagalistrikan Pada Pt Pln (Persero), Fadillah Isnan, Dwi Randi Sulistiyono, Fitrah Ramadhian

Technology and Economics Law Journal

The Indonesian government continues to strive to develop infrastructure, including electrical infrastructure, which serves as the main driver and foundation of the economy. The task of managing the electricity sector is entrusted to the state through state-owned enterprises, with PT PLN (Persero) as the main implementer. The planning for these electricity infrastructure projects has been outlined in the 2021-2030 Electricity Supply Business Plan (RUPTL). To support the realization of these projects, substantial funding is required, one of which is through a syndicated loan scheme. Syndicated loans, which involve a number of financial institutions, offer organized and efficient financing solutions with …

Peran Financial Technology Peer-To-Peer (P2p) Lending Dalam Mendukung Pengembangan Umkm Studi Kasus : Kampoeng Batik Laweyan, Isa Bisthomi, Januar Dwi Irawan, Launa Qisti

Technology and Economics Law Journal

Micro, Small, and Medium Enterprises (MSMEs) are the backbone of Indonesia's economy, absorbing 97% of the non-agricultural workforce and making a significant contribution to GDP. However, limited access to formal financing remains a major obstacle. Conventional banks often view MSMEs as high-risk, making it difficult for them to obtain loans. Peer-to-Peer (P2P) lending emerges as a technology-based solution, offering easier access to financing with lighter requirements and faster processes. This study aims to examine the role of P2P lending in enhancing financial inclusion and the capacity of MSMEs, focusing on the case study of Kampoeng Batik Laweyan in Solo. The …

Pembiayaan Syariah Pada Esco Dalam Menunjang Efisiensi Energi, Rizki Aulia, Theo Sammaranta Siregar, Yuda Puji Agustin

Technology and Economics Law Journal

Climate change and the need to reduce energy consumption make energy efficiency an important solution to achieve sustainability. Energy Services Companies (ESCOs) play a central role in the implementation of energy efficiency technologies through various services such as consulting, project development, and verification of energy savings. However, one of the main challenges in this implementation is the need for significant initial investment, which is often an obstacle for project owners, especially in developing countries where high financial risk is a major obstacle. Islamic financing, based on the principles of Islamic law, offers an attractive alternative to overcome such challenges. The …

Titanium Funds Llc, Plaintiff-Appellee V. Miu Parker, Defendant-Appellant. : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the final summary judgment entered in the Third Judicial District Court of Salt Lake County, State of Utah for the Appellees and the award of costs and attorney fees to the Appellees by the District Court; Judge Teresa Welch presiding. The minute entry was entered by the Trial Court on November 20, 2023 and the final judgment was entered on November 29,2023.

Lester A. Perry, Attorney for Appellant, Miu Parker

Chad C. Rasmussen, Attorney for Appellees

2025-02-11, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Kujegi Camara, Mark Naison

Oral Histories

Summary by Eliza Anderson.

Kujegi Camara is a lifelong Bronx resident and Assistant Director for Engagement and Operations at Fordham’s Center for Community Engaged Learning. She attended high school at Manhattan Center for Science and Math in East Harlem and received a bachelor's degree from Princeton University.

Camara was born in 1994 to Gambian parents who immigrated to the Bronx in the late ‘80s. Growing up on 176th and Walton Avenue, Camara lived with her large extended family and would cook meals with her mother and aunts. The neighborhood had many Senegambian immigrants, and the Mount Hope Masjid that she …

How Even Luxury Housing Can Help Solve The Housing Shortage, Kathleen Bolter

Reports

No abstract provided.

Join Uab Arts In Medicine For Mental Health Webinar Series, Shannon Thomason

Browse All News

No abstract provided.

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Examining The Relationship Between Casino Employee Gambling Involvement, Demographic Characteristics, And Responsible Gambling Program Perceptions, Tiange (Patrick) Xu, Shane W. Kraus, Brett Abarbanel, Eric R. Louderback, Heather M. Gray, Debi A. Laplante, Bo J. Bernhard

UNLV Gaming Research & Review Journal

This study investigated past-year gambling involvement (i.e., frequency and breadth) among employees at MGM Resorts International (MGM) and their views on the effectiveness of MGM’s responsible gambling (RG) program (i.e., GameSense). It also examined associations between these views and employees’ gambling behavior, as well as their demographic and work-related characteristics. We used cross-sectional data drawn from a broader research project, which surveyed a large sample of MGM employees (n = 814) in 2020. Our analysis revealed that gambling frequency varied by ethnicity, department affiliations, and property location, while gambling breadth differed based on gender and department affiliations. We employed …

The Evolution And Future Of Microservices Architecture With Ai-Driven Enhancements, Jill Willard, James Hutson

Faculty Scholarship

Microservices architecture has revolutionized software development by enabling the decomposition of monolithic applications into smaller, more manageable services. While this shift has reduced risks and enhanced system resiliency, the increasing complexity of managing numerous microservices presents new challenges. As Artificial Intelligence (AI) continues to evolve, there is a growing need to explore how autonomous AI agents can optimize microservices architectures, particularly in terms of communication and workflow orchestration. The purpose of this study is to investigate how AI agents can autonomously interact and manage microservices, reducing human intervention and enhancing system efficiency. The key research question guiding this investigation relates …

The Tie2 Antagonist Rebastinib Reduces Ovarian Cancer Growth In A Syngeneic Murine Model, Vijayalaxmi G Gupta, Katherine F Roby, Harsh B Pathak, Andrew K Godwin, Sumedha Gunewardena, Dineo Khabele

2020-Current year OA Pubs

BACKGROUND: The receptor tyrosine kinase TIE2 and its ligands, angiopoietins (ANGPTs), promote angiogenesis. In addition to expression on vascular endothelial cells, TIE2 is expressed on M2-like pro-tumorigenic macrophages. Thus, the TIE2 inhibitor rebastinib was developed as a potential therapy to address multiple cancers. The objective of this study was to determine the effects of rebastinib alone and combined with chemotherapy in a syngeneic murine model of ovarian cancer.

METHODS: Female C57Bl6J mice were intraperitoneally injected with syngeneic ID8 ovarian cancer cells. Once tumors were established, mice were untreated (control) or treated with rebastinib, carboplatin plus paclitaxel (chemotherapy), or rebastinib plus …

Repeat Expansion In A Fragile X Model Is Independent Of Double Strand Break Repair Mediated By Pol Θ, Rad52, Rad54 Or Rad54b, Bruce E Hayward, Geum-Yi Kim, Carson J Miller, Cai Mccann, Megan G Lowery, Karen Usdin

Faculty, Staff and Student Publications

Microsatellite instability is responsible for the human repeat expansion diseases (REDs). The mutagenic process differs from classical cancer-associated microsatellite instability (MSI) in that it requires the mismatch repair proteins that normally protect against MSI. LIG4, an enzyme essential for non-homologous end-joining (NHEJ), the major pathway for double-strand break repair (DSBR) in mammalian cells, protects against expansion in mouse models. Thus, NHEJ may compete with the expansion pathway for access to a common intermediate. This raises the possibility that expansion involves an NHEJ-independent form of DSBR. Pol θ, a polymerase involved in the theta-mediated end joining (TMEJ) DSBR pathway, has been …

Engineered Immunomodulatory Extracellular Vesicles From Epithelial Cells With The Capacity For Stimulation Of Innate And Adaptive Immunity In Cancer And Autoimmunity, Xin Luo, Fernanda G Kugeratski, Dara P Dowlatshahi, Hikaru Sugimoto, Kent A Arian, Li Huang, Sergio Lilla, Kelly Hodge, Sara R Zanivan, Valerie S Lebleu, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are generated by all cells. Systemic administration of allogenic EVs derived from epithelial and mesenchymal cells have been shown to be safe, despite carrying an array of functional molecules, including thousands of proteins. To address whether epithelial cells derived EVs can be modified to acquire the capacity to induce immune response, we engineered 293T EVs to harbor the immunomodulatory molecules CD80, OX40L and PD-L1. We demonstrated abundant levels of these proteins on the engineered cells and EVs. Functionally, the engineered EVs efficiently elicited positive and negative co-stimulation of human and murine T cells. In the setting of …

Trends In Osteopathic Medical Education: A Scoping Review, Katie Hoskins, Molly Montgomery, Abbey Griffith, Hannah Pollard, Debra Orr-Roderick, Darell Schmick, Jeanne Strausman, Sarah Wade, Melinda Robertson, Megan Dearmond

Faculty and Staff Publications

Context: Following the transition to a single graduate medical education (GME) accreditation system in 2020, leaders at American Association of Colleges of Osteopathic Medicine (AACOM) were interested in learning more about the research being done about osteopathic medical education leading up to that point in time.

Objectives: The objective of this scoping review was to identify trends in undergraduate and graduate osteopathic medical education and to determine where this information was being disseminated and the institutions who were creating the content.

Methods: Searches were conducted in eight databases: PubMed (National Center for Biotechnology Information [NCBI]), MEDLINE (Ovid), Embase (Elsevier), Cumulative …

Bbox1 Restrains Tbk1-Mtorc1 Oncogenic Signaling In Clear Cell Renal Cell Carcinoma, Chengheng Liao, Lianxin Hu, Liwei Jia, Jin Zhou, Tao Wang, Hua Zhong, Lei Dong, Lei Guo, Qian Liang, Cheng Zhang, Fangzhou Zhao, Jun Fang, Hongyi Liu, Shina Li, Lin Xu, Jeremy M Simon, Srinivas Malladi, Payal Kapur, James Brugarolas, Ralph J Deberardinis, Qing Zhang

Faculty, Staff and Student Publications

Clear cell renal cell carcinoma (ccRCC), a metabolic disease originating from renal proximal convoluted tubule (PCT) epithelial cells, remains incompletely understood in terms of its initiating signaling events. Here, we identify γ-butyrobetaine hydroxylase 1 (BBOX1), a key enzyme in carnitine synthesis predominantly expressed in PCT cells, as a tumor suppressor in ccRCC. BBOX1 expression is lost during ccRCC malignant transformation, and its restoration reduces cell viability in physiological medium and inhibits xenograft tumor growth. Transcriptomic analyses reveal that BBOX1 suppresses critical metabolic pathways including mTORC1 signaling and glycolysis in ccRCC. Further, we identify TANK-binding kinase 1 (TBK1) as an essential …

Nprl2 Gene Therapy Induces Effective Antitumor Immunity In Kras/Stk11 Mutant Anti-Pd1 Resistant Metastatic Non-Small Cell Lung Cancer (Nsclc) In A Humanized Mouse Model, Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Jing Wang, Jack A Roth

Faculty, Staff and Student Publications

Expression of NPRL2/TUSC4, a tumor-suppressor gene, is reduced in many cancers including NSCLC. Restoration of NPRL2 induces DNA damage, apoptosis, and cell-cycle arrest. We investigated NPRL2 antitumor immune responses in aPD1R/KRAS/STK11^mt NSCLC in humanized-mice. Humanized-mice were generated by transplanting fresh human cord blood-derived CD34 stem cells into sub-lethally irradiated NSG mice. Lung-metastases were developed from KRAS/STK11^mt/aPD1R A549 cells and treated with NPRL2 w/wo pembrolizumab. NPRL2-treatment reduced lung metastases significantly, whereas pembrolizumab was ineffective. Antitumor effect was greater in humanized than non-humanized-mice. NPRL2 + pembrolizumab was not synergistic in KRAS/STK11^mt/aPD1R tumors but was …

Trpv4 Dominates High Shear-Induced Initial Traction Response And Long-Term Relaxation Over Piezo1, Mohanish Chandurkar, Manli Yang, Majid Rostami, Sangyoon J. Han

Michigan Tech Publications

Modulation of endothelial traction is critical for the responses of endothelial cells to fluid shear stress (FSS), which has profound implications for vascular health and atherosclerosis. Previously, we demonstrated that under high FSS, endothelial cells rapidly increase traction forces, followed by relaxation, with traction aligning in the flow direction. In contrast, low shear preconditioning induces a modest short-term increase in traction (min), followed by a secondary long-term (>14 hr) rise, with traction/cells aligning perpendicular to the flow. The upstream mechanosensors driving these responses, however, remain unknown. Here, we sought the roles of Piezo1 and TRPV4 ion channels in shear-induced …

Enhancing Staff Impact On Medication Adherence In A Mental Health Outpatient Clinic, Uzoamaka Lynda Mbadugha

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project addressed the critical issue of medication nonadherence among mental health patients by implementing a staff education program at an outpatient clinic in the Mid-Atlantic region USA. The program focused on enhancing staff knowledge and confidence through training in psychoeducation, motivational interviewing, and multidisciplinary collaboration. Nonadherence often leads to relapse, hospitalization, and poor outcomes, compounded by a lack of structured interventions at the project site. Sixteen clinic staff members participated in biweekly training sessions over a one-month period. Pre- and post-training assessments revealed a 44.79% increase in staff knowledge and a 50% improvement in confidence …

Improving The Consistency And Accuracy Of Depression Screening Using The Phq-9 In A Behavioral Health Facility, Adaku Anike

Walden Dissertations and Doctoral Studies

Depression is one of the most common psychiatric illnesses and one of the main causes of disability globally. Currently, at behavioral care facility patients are not consistently screened during the initial and follow-up visits due to limited staff knowledge in using the Patient Health Questionnaire-9 (PHQ-9) screening tool. Evidence-based literature recommends depression screening be done at every initial and follow-up visit. The PHQ-9 tool is valid and reliable for identifying, diagnosing, and monitoring depression treatment outcomes. Inadequate use of the PHQ-9 tool can lead to several negative patient outcomes. The project practice-focused question was: Does comprehensive education increase the knowledge …

Promoting Consistency In Phq-9 Depression Screening For Young Adults In An Outpatient Mental Health Clinic., Abena V. Prempeh

Walden Dissertations and Doctoral Studies

This project aimed to improve the consistency of PHQ-9 depression screenings for young adults in an outpatient mental health clinic. Through the implementation of standardized protocols and staff training, the goal was to reduce variability in screening outcomes. The evaluation method of the project involved staff interviews, surveys, and comparing pretest and post-test results to measure staff knowledge and confidence improvements. The results showed that there were significant improvements in staff knowledge and confidence. This project highlights the importance of standardized procedures in improving mental health care for young adults.

Medical Readmissions In Coronary Artery Bypass Graft Patients And The Correlation With Physician Communication, Megan Vandyke

Walden Dissertations and Doctoral Studies

Rising costs in healthcare is a social problem in the United States with medical errors contributing to the rising costs; communication has been identified as a key contributor to medical errors. The purpose of this quantitative study was to further examine if there was a correlation between the independent variable of doctor communication scores and the dependent variable of readmission rates of coronary artery bypass graft surgery patients. This research could contribute to the social problem of rising healthcare costs specifically by identifying variables that may be contributors to costs due to errors. The theoretical framework was Donabedian’s theory of …

Scientific Evidence: Impact On A Jury, Thomas B. Scavone

Walden Dissertations and Doctoral Studies

The goal of this qualitative study was to better understand the impact of scientific evidence ‘s influence on a jury’s verdict. The presence of scientific evidence has the potential to convict the defendant or overturn a guilty verdict as seen in cases involving the innocence project. The theoretical framework for this qualitative study was Gerbner’s Cultivation Theory which postulates heavy exposure to television has the potential to influence the individual’s perception of the world. The researcher implemented an exploratory research design using purposive sampling. A total of 68 participants (prior jurors) applied for the study, 66 from an advertisement placed …

The Impact Of Age, Gender, Race, And Socioeconomic Background On Montana Students’ Reading Achievement, Robin Cormier

Walden Dissertations and Doctoral Studies

The problem in this study was that 88% of local Montana elementary school students were not proficient in reading by the end of the 2023–2024 school year. The study’s purpose was to determine whether a relationship existed between students' performance on standardized reading tests in the local school setting and the key variables: age, gender, race, and socioeconomic background. Grounded in Piaget’s constructivist theory of cognitive development, the analysis explored whether the demographic factors contributed to differences in reading performance. Using a quasi-experimental, ex post facto design, (N = 64) students were categorized by age, gender, race, and socioeconomic status. …

The Relationship Between Remote Followers’ Perceptions Of Leader’S Emotional Intelligence And Followers’ Psychological Safety, Gender, And Tenure, Jeanine P. Stroud

Walden Dissertations and Doctoral Studies

This quantitative study explored the relationship between remote workers’ perceptions of their leaders’ emotional intelligence and their self-reported psychological safety, with gender and tenure as moderating variables. Data from 172 remote employees using a cross-sectional online survey revealed that perceived leader emotional intelligence was a significant predictor of psychological safety, both as a composite measure and across its four dimensions of emotional intelligence: self-emotional appraisal, others’ emotional appraisal, regulation of emotion, and use of emotion. Gender moderated the relationship with the combined interaction of worker and leader gender in female leader–female follower dyads. Tenure with the leader did not moderate …

Agile Culture As Experienced By Scrum Masters In The Financial Sector, Andrew John Haigh

Walden Dissertations and Doctoral Studies

There is a high failure rate for software development projects, even those that have adopted an Agile approach, despite the United States spending more than $250 billion yearly on developing 175,000 software projects costing $2,322,000 on average. Scrum masters on software development projects with an Agile approach need to adopt more than just the process and procedures; they need to adopt the Agile culture. The purpose of this general qualitative study was to explore the implementation of the Agile culture experienced by scrum masters in the financial sector. The Scrum software development framework is the most popular variant of the …