Digital Commons Network^™

Spartan Daily, February 13, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 10

The Grizzly, February 13, 2025, Kate Horan, Sidney Belleroche, Renee Washart, Nathaniel Nerone, Claudia Tracy, Emily Veasey, Hadley Whitman, Jesse Cherone

Ursinus College Grizzly Newspaper, 1978 to Present

The Launch of Soulful Creations • Annual UC Career Fair Coming Soon! • CIE Syllabus Change Proposals • Professor Pairs • Behind Their Doors: Meet the New Staff of Ursinus • Valentine's Day: Friend or Foe? • Shattering Limits: Bears Break School Records • Basketball Bears Push Towards Playoffs!

Professor Kirk Burkhalter ’04 Appointed Dean For Evening Division Engagement, Anthony W. Crowell

NYLS Community News

No abstract provided.

Examining The Flavor Descriptors Of E-Cigarettes, Heated Tobacco Products, And Nicotine Pouches In The Philippines: Regulatory Challenges And Opportunities, Samantha J. Ackary, Patrik James D.L. Cabrera, Alen Josef A. Santiago, Gianna Gayle H. Amul

Ateneo School of Government Publications

In the Philippines, the regulation of e-cigarettes, heated tobacco products (HTPs), and nicotine pouches under Republic Act 11900 or the Vape Law is crucial as their use continues to rise. As e-cigarettes are rapidly gaining popularity due to their social appeal, perceived novelty, ever-changing flavors, and sensations that are attractive to consumers, HTPs and nicotine pouches are continuously developing as well. This study aims to characterize e-cigarette, HTP, and nicotine pouch flavor descriptors in the Philippines and to assess the regulatory implications of existing policies regulating these products. We adapted the Tobacco Pack Surveillance System (TPackSS) data collection protocol developed …

Montana Kaimin, February 13, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Freeing Bead From Its Bureaucratic Shackles, Michael Santorelli

Other Publications

No abstract provided.

Winter Dance Concert, February 13-15, 2025, Lindenwood University

Student Dance Programs & Brochures

Event program for the Winter Dance Concert, February 13-15, 2025, Lindenwood University.

Pharmacist Avoidance Or Reductions In Medical Costs Considering Board Of Pharmacy Specialties Certification (Pharm-Bps)., Keaton S Smetana, Edith Liang, William Adams, Payal K Gurnani, William J Peppard, Alexander H Flannery, Megan A Rech

Pharmacy Articles

No abstract provided.

Viscoelastic Protective Armor Liners And Protective Armor, Fatih Dogan, Cody Thomas, Catherine Johnson

Materials Science and Engineering Faculty Research & Creative Works

No abstract provided.

Beyond Lectures: Leveraging Competition, Peer Discussion And Real-World Scenarios In A Digital Card Game To Enhance Learning Of Microbiology And Immunology Concepts, Michael Dillon, James Edwards, Alexandra Hughes, Holly Stephenson

Peninsula Medical School

Teaching the complex interactions between hosts and pathogens is a fundamental yet educationally challenging aspect of life science and healthcare education. The intricate mechanisms of the immune system can pose significant barriers to students’ understanding of infectious disease diagnosis and treatment. To address this, we used a web-based digital whiteboard platform to design a card-based competitive game called Micro-Immune Battles, aimed at more actively engaging students with microbiology and immunology to better develop their knowledge and underlying concepts. The game facilitates learning through a series of infectious disease scenarios, providing student teams with ‘immune system response cards’ that represent various …

Long-Term 3-Year Follow-Up Of Mosunetuzumab In Relapsed Or Refractory Follicular Lymphoma After ≥2 Prior Therapies, Laurie H Sehn, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

Mosunetuzumab, a CD20×CD3 T-cell engaging bispecific antibody, redirects T cells to eliminate malignant B cells. We present updated efficacy and safety data of a pivotal phase 1/2 study after a median follow-up of 37.4 months in 90 patients with relapsed/refractory (R/R) follicular lymphoma (FL) and ≥2 prior lines of therapy treated with fixed-duration mosunetuzumab. Investigator-assessed complete response (CR) rate and objective response rate were 60.0% (95% confidence interval [CI], 49.1-70.2) and 77.8% (95% CI, 67.8-85.9), respectively. Among 70 responders, median duration of response was 35.9 months (95% CI, 20.7 to not estimable [NE]). Among 54 patients who achieved CR, 49 …

2025 Annual Ancestors Lecture Fishing Through Flux: Economic Strategies For Managing El Niño Risks In Coastal Peru, Dr. Jo Osborn

LAII Events

Thursday, February 113, 2025 @ 6:30

UNM Maxwell Museum

Hibben Center Rm 105 + Zoom

How do communities confront challenging climatic circumstances? This talk explores the development of community economic specialization at Jahuay (200 BC–AD 150), a fishing village on the Peruvian south coast where full-time maritime specialists made a living through fishing, shellfish collection, and the hunting of marine birds and mammals. These products were consumed locally and exchanged regionally. I propose complementarity between independent specialized communities exploiting distinct resources was a regional strategy that buffered against periodic scarcity and made communities more resilient to El Niño cycles.

The Human World Along With The Gods: Reflections Of Humanity Behind The Divine 诸神的人间: 神迹背后亦是人间缩影, Xin Cang 苍鑫

Zhou Documents

The article explores the artist's eight new works in the exhibition The Human World along with The Gods, providing detailed descriptions and analyses. The works span a range of media, including video, sculpture, painting, and installation, reflecting the artist's exploration of the complex relationships between humanity, divinity, and nature. The article is available in both Chinese and English. (Angela Tan '28)

Pharmacogenomics Implications Of Tamoxifen In Breast Cancer Treatment: Clinical Relevance And Future Directions, Khalda E. M. Elhaj, Mahmoud M. E. Mudawi, Hamad A. Albagir A. Ali, Kamal A.A. Mohammed

Saudi Toxicology Journal

Tamoxifen is a cornerstone therapy for estrogen receptor-positive (ER+) breast cancer, improving survival and reducing recurrence. Its efficacy and toxicity, however, vary due to genetic polymorphisms influencing metabolism and transport. Key genes, such as CYP2D6, CYP3A4, and ATP-binding cassette transporters (ABCB1, ABCC2), are crucial in forming and distributing active metabolites like endoxifen. This review explores tamoxifen pharmacogenetics through an analysis of literature from PubMed, Scopus, Google Scholar, and PharmaGKB. Genetic variations like CYP2D6*10 in Asians and CYP2D6*17/29 in Africans impact therapeutic outcomes. Barriers to personalized tamoxifen therapy include inconsistent guidelines, limited access to genetic testing, and underrepresentation of ethnic groups …

University Of Northern Iowa Graduate Council Minutes, February 13, 2025, University Of Northern Iowa. Graduate Council.

Documents - Graduate Council

Meeting minutes from the Graduate Council of the University of Northern Iowa.

Treatment Of Small Intracranial Aneurysms Using The Smallss Scoring System: A Novel System For Decision Making, Mira Salih, Michael Young, Thomas B. Fodor, Alexander Andreev, Samuel D. Pettersson, Joanna M. Roy, Basel Musmar, Max Shutran, Phillip Taussky, Christopher S. Ogilvy

Department of Neurosurgery Faculty Papers

BACKGROUND: Treatment of unruptured intracranial aneurysms (UIA) less than 7 mm is controversial. We created a scoring system to guide decision making and validated the system utilizing over 700 cases treated with microsurgery or endovascular procedures.

METHODS: The scoring system SMALLSS included Size, (4-7 mm: 1 point, < 3.9 mm: 0 point), Multiple aneurysms (yes: 1, no: 0), Anatomic location (posterior: 1, anterior: 0), Lineage- family history of aneurysm (yes:1, no: 0), Lifetime risk (age < 65: 1, age > 65: 0), Smoking history (yes: 1, no: 0 ), Shape (irregular:1, smooth:0 ). Validation of this system was performed through retrospective review of prospectively maintained data for UIA patients treated between 2014 and 2021. We then performed an external validation of a cohort of 200 small aneurysms < 7 mm treated at a high volume cerebrovascular center.

RESULTS: A total of 1152 cases …

Spectator 2025-02-13, Editors Of The Spectator

The Spectator

No abstract provided.

Associations Between Atmospheric Ozone, Pm2.5 And Prevalence Of Diabetes In Georgia, United States, Kingsley A. Kalu, Jingjing Yin, Atin Adhikari

Journal of the Georgia Public Health Association

Objective:

This study examines the association between two air pollutants (PM_2.5 and ozone), and the prevalence of adult diabetes mellitus in relation to various confounding factors.

Methods:

We collected diabetes prevalence data from the 2015 County Health Ranking and Georgia Health Data Hub. A negative binomial regression analysis was conducted to examine the associations between the county-level dependent variable “adult diabetes” (for adults aged> 18 years diagnosed with Type 1 and Type 2 diabetes) and two independent county-level variables: percentage of days ³ NAAQS for ozone and PM_2.5 concentration levels while controlling for confounders.

Results:

At the county …

Perspectives Of African American And Hispanic/Latino Individuals On Hiv Molecular Cluster Detection, Maxwell Richardson, Brendan H. Pulsifer, Jane Yoon Scott, David Holland, Eleanor W. Garlow, Pascale Wortley, Daniel Mauck, Jenna Gettings, Valeria Cantos, Masonia Traylor, Eric Rangel, David Folkes, Carlos Saldana

Journal of the Georgia Public Health Association

Background: Responding to HIV clusters detected using molecular data has been shown to reduce transmission and improve testing, treatment, and prevention. However, there are varied opinions about the use of cluster detection activities, and some advocates have raised concerns about patient consent, data security, and the potential for HIV criminalization. Incorporating the perspectives of marginalized populations that are disproportionately affected by HIV is essential to understanding the diversity of those perspectives, yet it is often overlooked in the literature. Thus, our study seeks to highlight the perspectives of Black/African American and Hispanic/Latino individuals in the Southern United States on HIV …

May 4, See Rhiannon Giddens & The Old-Time Revue At Uab's Alys Stephens Center, Shannon Thomason

Browse All News

No abstract provided.

Affect Regulation And Mortality Risk: The Role Of Allostatic Load, Amanda E. Ng, Tara Gruenewald, Robert-Paul Juster, Claudia Trudel-Fitzgerald

Psychology Faculty Articles and Research

Objective:

Although growing evidence indicates that distinct affect regulation strategies (e.g., positive reappraisal, anger suppression) predict mortality risk, the biological processes involved remain understudied. We investigated the association of various affect regulation exposures with mortality risk while examining the role of allostatic load.

Method:

In 2004-2006, 1,941 participants from the Midlife in the United States longitudinal study completed validated scales assessing use of nine general and emotion-specific regulatory strategies (e.g., denial, anger expression). A standard deviation-based algorithm was also used to characterize how flexibly participants regulate their affect (lower, moderate, or greater variability). Participants further provided data on relevant covariates …

Phages Carry Orphan Antitoxin-Like Enzymes To Neutralize The Dartg1 Toxin-Antitoxin Defense System, Anna Johannesman, Leila C Awasthi, Nico Carlson, Michele Leroux

2020-Current year OA Pubs

The astounding number of anti-phage defenses encoded by bacteria is countered by an elaborate set of phage counter-defenses, though their evolutionary origins are often unknown. Here, we report the discovery of an orphan antitoxin counter-defense element in T4-like phages that can overcome the bacterial toxin-antitoxin phage defense system, DarTG1. The DarT1 toxin, an ADP-ribosyltransferase, modifies phage DNA to prevent replication while its cognate antitoxin, DarG1, is a NADAR superfamily ADP-ribosylglycohydrolase that reverses these modifications in uninfected bacteria. We show that some phages carry an orphan DarG1-like NADAR domain protein, which we term anti-DarT factor NADAR (AdfN), that removes ADP-ribose modifications …

February 14, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

February 13, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Macbeth

Theatre and Performance Studies Programs

What happens when people with power go unchecked, especially when that power is driven by desires and emotions? Is morality lost? What are the repercussions of tyranny? Kennesaw State University’s Department of Theatre and Performance Studies (TPS) will examine those questions as they present “Macbeth” running Feb. 13-23 at the Stillwell Theater. TPS Faculty and Director Marlon Andrew Burnley says that the play “explores the destructive power of ambition, the fragility of the human soul, and the consequences of choices made in pursuit of power.”

Non-Orientable Surfaces Bounded By Knots, Megan K. Fairchild

LSU Doctoral Dissertations

The non-orientable 4-genus of a knot $K$ in $S^{3}$ is defined to be the minimum first Betti number of a non-orientable surface $F$ in $B^{4}$ so that $K$ bounds $F$. We will survey the tools used to compute the non-orientable 4-genus, and use various techniques to calculate this invariant for non-alternating 11 crossing knots, torus knots, and Whitehead doubles. We also will view obstructions to a knot bounding a M\"{o}bius band given by the double branched cover of $S^{3}$ branched over $K$. Additionally, we discuss the problem of the Whitehead double of the Figure 8 knot and survey commonly used …

Structure-Activity Relationship Studies Of Dna Methyltransferase 1 Monovalent Degraders, Chao Qian, Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Ling Xie, H Ümit Kaniskan, Xian Chen, Scott Rothbart, Xiaodong Cheng, Yan Xiong, Jian Jin

Faculty, Staff and Student Publications

DNA methyltransferase 1 (DNMT1), which catalyzes maintenance methylation of hemimethylated DNA during DNA replication, is overexpressed in cancer. Recently, the first-in-class DNMT1-selective noncovalent small-molecule inhibitors, GSK3484862 and GSK3685032, were discovered. These inhibitors were also reported to degrade DNMT1. However, structure–activity relationship (SAR) studies of these monovalent DNMT1 degraders are lacking. Here, we report our SAR studies of this scaffold on degrading DNMT1, which led to the discovery of multiple lead degraders, including compound 4 (MS9024). Compound 4 potently and selectively degraded DNMT1 in multiple cancer cell lines in a concentration-, time-, and proteasome-dependent manner without altering DNMT1 transcription. Further mechanism-of-action …

Inhibition Of Histone Methyltransferase Ezh2 For Immune Interception Of Colorectal Cancer In Lynch Syndrome, Charles M Bowen, Fahriye Duzagac, Abel Martel-Martel, Laura Reyes-Uribe, Mahira Zaheer, Nan Deng, Soham Mazumdar, Melissa W Taggart, Abhinav K Jain, Elena Tosti, Winfried Edelmann, Krishna M Sinha, Eduardo Vilar

Faculty, Staff and Student Publications

Colorectal precancers in Lynch syndrome (LS) exhibit a distinct immune profile, presenting unique opportunities for developing immune-interception strategies to prevent carcinogenesis. Epigenetic modulation by EZH2 of immune-related genes is implicated in the carcinogenesis of different cancer types, including colorectal cancer. This study utilizes a mouse model of LS and ex vivo colonic organoids to assess the effects of the EZH2 inhibitor GSK503 on immune regulatory pathways, tumorigenesis, and epigenetic reprogramming. Our findings revealed that GSK503 significantly increased CD4+ and CD8+ T cells in both splenocytes and colonic mucosa of treated mice compared with controls. Additionally, a preventive dose of GSK503 …

Successful Posthospitalisation Oncology Workflow Implementing Lace+ Score To Stratify And Reduce Readmissions Within A Safety-Net Hospital, Lianchun Xiao, Vinita Akula, Saumil Datar, Taylor Hopper, Yaser Alkhatib, Terri Earles, Tejal Patel

Faculty, Staff and Student Publications

Background: Patients with advanced cancers visit the emergency room and get hospitalised frequently, with potentially half of these visits being avoidable. Our institution provides comprehensive, low-cost cancer treatment to a safety-net population in Texas. We performed a retrospective review of hospital readmission patterns amongst our oncology patients and developed a posthospitalisation workflow to reduce readmissions.

Method: Following discharge, oncology patients were risk stratified based on their Length of stay, Acuity of admission, Charlson comorbidity index score and Emergency department visits+index in the past 6 months. The higher the score, the quicker the outpatient oncology follow-up. In addition to addressing acute …

Increasing Colorectal Cancer Screening Completion Rate Among African American Patients By Staff Education, Sloan Mccoy

Walden Dissertations and Doctoral Studies

Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States and disproportionately affects the African American population with a higher incidence and mortality rate. This DNP project was implemented in a suburban primary care practice which is part of a large metropolitan health care organization. I implemented staff education about the CRC completion disparity with the African American population and communication strategies found to help improve this. My goal was for the primary care practice staff to increase their knowledge and change their practice behavior with recommending CRC screening to improve CRC screening rates amongst …