Digital Commons Network^™

President Chilton Delivers 2025 State Of The University Address, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

February 17, 2025

The Gavel Gazette

No abstract provided.

02.17.2025 Ored Connect, Liz Williamson

ORED Newsletter

SOP Research Day

Men’S Hockey Took On Merrimack College In A Back-And-Forth Game Losing, 5-4, Melissa Gold

Digital Edition

No abstract provided.

Trump Administration Eliminates Diversity, Equity, And Inclusion Initiatives, Affecting College Landscapes Across The Nation, Rebecca Colby

Digital Edition

No abstract provided.

The Echo: February 17, 2025, Taylor University

2024-2025 (Volume 112)

No abstract provided.

Cover

LSU Journal of Energy Law and Resources

No abstract provided.

Masthead

LSU Journal of Energy Law and Resources

No abstract provided.

Faculty

LSU Journal of Energy Law and Resources

No abstract provided.

Is An Exclusive Pipeline Servitude Actually Exclusive? The Louisiana Second Circuit Opines, Ryan M. Seidemann

LSU Journal of Energy Law and Resources

No abstract provided.

Should Owners Of American Land Be . . . American? An Examination Of The Global Implications Of U.S. Agricultural Land Ownership And The Need For A Federal Regulation, Mattie Zepernick

LSU Journal of Energy Law and Resources

No abstract provided.

The Texas Two-Step And Rights Of First Refusal: How Courts Should Interpret Preferential Rights Provisions In Stock Transfer Transactions, Isabelle Rowan

LSU Journal of Energy Law and Resources

No abstract provided.

We Know About The Right To Bear Arms, But What About The Rights Of Bears Ears, Brandon Andrews

LSU Journal of Energy Law and Resources

No abstract provided.

The Case Against E-Waste In The Bayou State: Proposing E-Waste Recycling Legislation In Louisiana, Elizabeth Bueche

LSU Journal of Energy Law and Resources

No abstract provided.

America Runs On Biodiesel: Implementation Of A New Federal Mandate For Increased Renewable Energy Fuel, Asia Jackson

LSU Journal of Energy Law and Resources

No abstract provided.

Analysis Of Disparities Within The Ncaa’S Name, Image, And Likeness Rule, Madison Salzenstein

Honors Theses

Abstract

This paper analyzes disparities with the NCAA’s Name, Image, and Likeness (NIL) Rule. The 2021 introduction of the NIL Rule was a landmark event, allowing college athletes to profit from their personal brand. While NIL has resulted in many positive opportunities for college athletes, it is not without fault. Specifically, this thesis will explain how NIL amounts differ between both male and female athletes and revenue and non-revenue sports, and will explain the key factors contributing to the disparity in each area.

Using data obtained from the NCAA’s NIL Assist Data Dashboard for the period January through December 2024, …

Waste Audit Assesses Recycling Habits To Inform Education To Peers On Campus, Erin Classey

Sustainability Institute Blog

No abstract provided.

Sustainability Seed Grant Program Announces 2025 Award Recipients, Betty Woodman

Sustainability Institute Blog

No abstract provided.

Ndls Communicator: Week Of 02.17.25, Notre Dame Law School

NDLS Communicator

The Latest News

• ND Law Global Human Rights Clinic advocates for human rights before United States International Trade Commission
• ND Law's Black Students Association celebrates Black History Month and the pursuit of justice
• Professor Jorge Barrera-Rojas defends dissertation to earn two doctoral degrees
• Notre Dame Law School's Religious Liberty Clinic secures asylum for Iranian Christian convert facing persecution

Faculty News and Briefs

• Paul Miller was cited in an important dissenting opinion by Justices Gordon, Edelman, and Steward of the High Court of Australia for his work on fiduciary obligations.
• This week, A.J. Bellia will speak on the legal implications of …

Small Molecule-Mediated Inhibition Of The Oxidoreductase Ero1a Restrains Aggressive Breast Cancer By Impairing Vegf And Pd-L1 In The Tumor Microenvironment, Ersilia Varone, Jaehyung Cho, Et Al.

2020-Current year OA Pubs

Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide oxidase, and under cancer-related hypoxia conditions, it favors the folding of angiogenic VEGFA, leading tumor cells to thrive and spread. The upregulation of ERO1A in cancer cells, oppositely to the dispensability of ERO1A activity in healthy cells, renders ERO1A a perfect target for cancer therapy. Here, we report the upregulation of ERO1A in a cohort of aggressive triple-negative breast cancer (TNBC) patients in which ERO1A levels correlate with a higher …

The Lymph Trial: Comparing Microsurgical With Conservative Treatment For Chronic Breast Cancer-Associated Lymphoedema - Study Protocol Of A Pragmatic Randomised International Multicentre Superiority Trial, Elisabeth A Kappos, Justin M Sacks, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Up to one-fifth of breast cancer survivors will develop chronic breast cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) and vascularised lymph node transfer (VLNT) are microsurgical techniques that aim to restore lymphatic drainage. This international randomised trial aims to evaluate advantages of microsurgical interventions plus CDT versus CDT alone for BCRL treatment.

METHODS AND ANALYSIS: The effectiveness of LVA and/or VLNT in combination with CDT, which may be combined with liposuction, versus CDT alone will …

The Rider (2025-02-17), Rebeca Salinas

The Rider Archives

Vol. 10, No. 19

A Roadmap To Precision Medicine Through Post-Genomic Electronic Medical Records, Kevin M. Mendez, Stacey N. Reinke, Rachel S. Kelly, Qingwen Chen, Mark Su, Michael Mcgeachie, Scott Weiss, David I. Broadhurst, Jessica A. Lasky-Su

Research outputs 2022 to 2026

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine.

Residence, Education, Wealth, And Hiv/Aids Prevention Knowledge Among Nigerian Adults, Chinedu Nwaobia Nwaru

Walden Dissertations and Doctoral Studies

HIV has remained the most prevalent and deadliest epidemic affecting humanity. It is pertinent to note that, despite the number of years since the first case was reported in the early 1980s in the United States, and concerted efforts by local, national, and international governmental and nongovernmental agencies at curbing it, the level of knowledge of HIV transmission and the disease prevention, especially among Nigerians, is still not encouraging. Nigeria, the most populous country in Sub-Saharan Africa ranks second globally as the country with the highest number of people living with HIV/AIDS, which is currently estimated at 3 million. In …

Strategies For Improving Phlebotomy Training Programs In Midwestern Nonprofit Acute Care Hospitals, Zaid Naima

Walden Dissertations and Doctoral Studies

Preanalytical errors in laboratory testing represent a significant challenge in healthcare delivery, accounting for most laboratory errors. Inadequate and inconsistent phlebotomy training has been identified as a major contributor to high rates of preanalytical errors and specimen rejection in nonprofit acute care hospitals within multihospital health systems in the U.S. Midwest region. The aim of this integrative review was to identify best practices and strategies for improving on-the-job phlebotomy training programs in Midwestern nonprofit acute care hospitals within multihospital health systems, using the Donabedian model as a framework to enhance specimen quality, reduce rejection rates, and increase patient satisfaction. A …

Staff Education On The Importance Of Using Sequential Compression Devices To Prevent Venous Thromboembolism In A Hospital Medical Surgical Unit, Roxanne Rose Beckman

Walden Dissertations and Doctoral Studies

Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary emboli, can lead to disability, loss of limbs, or even death. VTEs are preventable and can affect anyone at any age, race, or gender. In the United States, it is estimated each year that as many as 900,000 people are affected by VTEs. Risk factors for developing blood clots are immobilization, surgeries, pregnancy, obesity, history of blood clots, and trauma. Hospital-acquired VTE is a patient safety indicator, and mechanical prophylaxis should always be used to lessen the risk unless contraindicated. Sequential compression devices (SCDs), a preferred method of VTE prophylaxis, …

Medical Laboratory Technologist Labor Market And Industry Initiatives To Address Labor Shortages, Jarvis John Surriga

Walden Dissertations and Doctoral Studies

The demand for laboratory testing has increased, requiring more medical laboratory technologists/scientists (MLTs/MLSs) in the United States. However, the supply of qualified MLS workers has decreased, which has caused a critical labor shortage. The purpose of this integrative review was to determine the best practices and strategies for improving the staffing and retention of clinical laboratory staff (CLS) given the growing demand for laboratory services. A search of empirical and nonempirical literature published between 2019 and 2024 yielded 1,935 articles, and exclusions resulted in 66 articles that addressed the problem. The additional examination resulted in 26 articles chosen for further …

Rna Methyltransferase Spout1/Cenp-32 Links Mitotic Spindle Organization With The Neurodevelopmental Disorder Spadmiss, Reza Maroofian, Tristan T Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A Wear, Kiara E Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K Lee, Christine H Umandap, Sara M Berger, Alejandro D Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L Rippert, Christopher Gray, Kosuke Izumi, Laura K Conlin, Daniel C Koboldt, Theresa Mihalic Mosher, Scott E Hickey, Dara V F Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E Posey, Natalie C Lippa, Natalie Vena, Erin L Heinzen, David B Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S Zaki, Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N Wontakal, Vimla S Aggarwal, Jill A Rosenfeld, Victor Tarabykin, Shinya Ohta, James R Lupski, Henry Houlden, William C Earnshaw, Erica E Davis, A Arockia Jeyaprakash, Jun Liao

Faculty, Staff and Students Publications

SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays from 21 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing. Zebrafish spout1/cenp-32 mutants show reduction in larval head size with concomitant apoptosis likely associated with altered cell cycle progression. In vivo complementation assays in zebrafish indicate that SPOUT1/CENP-32 missense variants identified in humans are pathogenic. Crystal structure analysis of SPOUT1/CENP-32 reveals that most disease-associated missense variants are …

Markedly Elevated Blood Pressure, Tachycardia, And Altered Consciousness In Patients With Bacteremia During Transurethral Surgeries: Two Case Reports, Riko Uchida, Hiroshi Matsuura, Naoko Torii, Naoko Fujita, Taku Hamada, Ai Nakamoto, Noriko Yoshikawa

Faculty, Staff and Students Publications

Background: Transurethral surgery is often accompanied by postoperative urinary tract infection. Although early detection and adequate treatment of bacteremia are required to prevent sepsis, it is usually undetectable during surgery. We report two cases with remarkable hypertension and tachycardia during transurethral surgery in which bacteremia was diagnosed by an intraoperative blood test.

Case presentation: An 80-year-old man (Case 1) underwent transurethral holmium laser prostate enucleation under spinal anesthesia, and an 88-year-old woman (Case 2) underwent transurethral resection of bladder tumor under general anesthesia. Altered consciousness (Case 1) and postoperative delirium (Case 2) were noted, in addition to remarkable intraoperative hypertension …

Inhale Wp3, A Multicentre, Open-Label, Pragmatic Randomised Controlled Trial Assessing The Impact Of Rapid, Icu-Based, Syndromic Pcr, Versus Standard-Of-Care On Antibiotic Stewardship And Clinical Outcomes In Hospital-Acquired And Ventilator-Associated Pneumonia, Inhale Wp3 Study Group And Committees, Virve I Enne, Susan Stirling, Julie A Barber, Juliet High, Charlotte Russell, David Brealey, Zaneeta Dhesi, Antony Colles, Suveer Singh, Robert Parker, Mark Peters, Benny P Cherian, Peter Riley, Matthew Dryden, Ruan Simpson, Nehal Patel, Jane Cassidy, Daniel Martin, Ingeborg D Welters, Valerie Page, Hala Kandil, Eleanor Tudtud, David Turner, Robert Horne, Justin O'Grady, Ann Marie Swart, David M Livermore, Vanya Gant

Peninsula Medical School

PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP).

METHODS: This pragmatic multicentre, open-label RCT enrolled adults and children with suspected HAP and VAP at 14 ICUs. Patients were randomly allocated to standard of care, or rapid in-ICU syndromic PCR coupled with optional prescribing guidance. Co-primary outcomes were superiority in antibiotic stewardship at 24 h and non-inferiority in clinical cure of pneumonia 14 days post-randomisation. Secondary outcomes included mortality, ICU length of stay and evolution of clinical scores.

RESULTS: 554 eligible patients were recruited from …