Digital Commons Network^™

Nyls Receives Top Grades For Academic Programs In Prelaw, Allison Gillingham

NYLS Community News

No abstract provided.

Single-Cell Analysis Of Neoplastic Plasma Cells Identifies Myeloma Pathobiology Mediators And Potential Targets, Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Hans C Lee, Pei Lin, David E Mery, Fenghuang Zhan, John D Shaughnessy, Qing Yi, Yang Song, Bo Jiang, Maura L Gillison, Sheeba K Thomas, Donna M Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E Manasanch, David E Symer, Robert Z Orlowski

Faculty, Staff and Student Publications

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models. Moreover, functional studies show a …

Iroc Phantoms Accurately Detect Mlc Delivery Errors, Sharbacha S Edward, Julianne M Pollard-Larkin, Peter A Balter, Rebecca M Howell, Christine B Peterson

Faculty, Staff and Student Publications

Purpose: We evaluated the impact of random and whole-bank multileaf collimator (MLC) delivery errors on dosimetric delivery accuracy in the Imaging and Radiation Oncology Core (IROC) phantom audits, as well as differences in delivery accuracy between the IROC phantom prescription and typical clinical fraction sizes.

Methods and materials: Plans were created for the IROC IMRT head and neck (H&N) and SBRT spine phantoms. MLC leaf errors were introduced into the plans: random shifts between -2 and 2 mm, and whole bank shifts of 0.5, 1, and 2 mm. Plans were recalculated and delivered on a Varian Truebeam, and the log …

Nanrilkefusp Alfa (Sot101), An Il-15 Receptor Βγ Superagonist, As A Single Agent Or With Anti-Pd-1 In Patients With Advanced Cancers, Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Peter Grell, Patricia Lorusso, Romana Mikyskova, Nada Podzimkova, Milan Reinis, Kaissa Ouali, Andreu Schoenenberger, Joachim Kiemle-Kallee, Sascha Tillmanns, Richard Sachse, Ulrich Moebius, Radek Spisek, David Bechard, Lenka Palova Jelinkova, Irena Adkins, Aurelien Marabelle

Faculty, Staff and Student Publications

Nanrilkefusp alfa (nanril; SOT101) is an interleukin (IL)-15 receptor βγ superagonist that stimulates natural killer (NK) and CD8

Mitochondrial Defects And Metabolic Vulnerabilities In Lynch Syndrome-Associated Msh2-Deficient Endometrial Cancer, Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, Collene Jeter, M Anna Zal, Philip L Lorenzi, Kenneth Dunner, Richard K Yang, Russell R Broaddus, Joseph Celestino, Nisha Gokul, Elizabeth Whitley, Deena M Scoville, Tae Hoon Kim, Jae-Wook Jeong, Rosemarie Schmandt, Karen Lu, Hyun-Eui Kim, Melinda S Yates

Faculty, Staff and Student Publications

Lynch syndrome (LS), caused by inherited mutations in DNA mismatch repair genes, including MSH2, carries a 60% lifetime risk of developing endometrial cancer (EC). Beyond hypermutability, mechanisms driving LS-associated EC (LS-EC) remain unclear. We investigated MSH2 loss in EC pathogenesis using a mouse model (PR-Cre Msh2LoxP/LoxP, abbreviated Msh2KO), primary cell lines, human tissues, and human EC cells with isogenic MSH2 knockdown. By 8 months, 58% of Msh2KO mice developed endometrial atypical hyperplasia (AH), a precancerous lesion. At 12-16 months, 50% of Msh2KO mice exhibited either AH or ECs with histologic similarities to human LS-ECs. Transcriptomic profiling of EC from Msh2KO …

Natural And Bioengineered Extracellular Vesicles In Diagnosis, Monitoring And Treatment Of Cancer, Xin Luo, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other …

An Integrative Multiparametric Approach Stratifies Putative Distinct Phenotypes Of Blast Phase Chronic Myelomonocytic Leukemia, Kristian Gurashi, Yu-Hung Wang, Fabio M R Amaral, Katherine Spence, Rachel Cant, Chien-Chin Lin, David C Wedge, Guillermo Montalban-Bravo, Simona Colla, Hwei-Fang Tien, Tim C P Somervaille, Kiran Batta, Daniel H Wiseman

Faculty, Staff and Student Publications

Approximately 30% of patients with chronic myelomonocytic leukemia (CMML) undergo transformation to a chemo-refractory blastic phase (BP-CMML). Seeking novel therapeutic approaches, we profiled blast transcriptomes from 42 BP-CMMLs, observing extensive transcriptional heterogeneity and poor alignment to current acute myeloid leukemia (AML) classifications. BP-CMMLs display distinctive transcriptomic profiles, including enrichment for quiescence and variability in drug response signatures. Integrating clinical, immunophenotype, and transcriptome parameters, Random Forest unsupervised clustering distinguishes immature and mature subtypes characterized by differential expression of transcriptional modules, oncogenes, apoptotic regulators, and patterns of surface marker expression. Subtypes differ in predicted response to AML drugs, validated ex vivo in …

Unveiling The Genetic Landscape Of Coronary Artery Disease Through Common And Rare Structural Variants, Adam S Heath, Jai G Broome, Alyna T Khan, Joshua P Lewis, Huichun Xu, May E Montasser, Kellan E Ashley, Natalie R Hasbani, Eric Boerwinkle, Alanna C Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M Lloyd-Jones, Rozenn N Lemaitre, Joshua C Bis, James S Floyd, Gregory L Kinney, Donald W Bowden, Nicholette D Palmer, Emelia J Benjamin, Matthew Nayor, Lisa R Yanek, Brian G Kral, Lewis C Becker, Sharon L R Kardia, Jennifer A Smith, Lawrence F Bielak, Arnita F Norwood, Yuan-I Min, April P Carson, Wendy S Post, Stephen S Rich, David Herrington, Xiuqing Guo, Kent D Taylor, Joann E Manson, Nora Franceschini, Katherine S Pollard, Braxton D Mitchell, Ruth J F Loos, Myriam Fornage, Lifang Hou, Bruce M Psaty, Kendra A Young, Elizabeth A Regan, Barry I Freedman, Ramachandran S Vasan, Daniel Levy, Rasika A Mathias, Patricia A Peyser, Laura M Raffield, Charles Kooperberg, Alex P Reiner, Jerome I Rotter, Goo Jun, Paul S De Vries, Themistocles L Assimes

Faculty, Staff and Student Publications

Background: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear.

Method and results: We leveraged SVs detected from high-coverage whole genome sequencing data in a diverse group of participants from the National Heart Lung and Blood Institute's Trans-Omics for Precision Medicine program. Single variant tests were performed on 58 706 SVs in a study sample of 11 556 CAD cases and 42 907 controls. …

Probing Ion-Blocking Electrode Rigs For Ionic Conductivity In Hybrid Solid Polymer Electrolytes, Kyra Glassey, Gabriela Roman-Martinez, Liliana Delatte, Thomas Burns, Monirosadat Sadati, Paul T. Coman, Ralph E. White

Faculty Publications

Solid electrolytes are critical for structural batteries, combining energy storage with structural strength for applications like electric vehicles and aerospace. However, achieving high ionic conductivity remains challenging, compounded by a lack of standardized testing methodologies. This study examines the impact of experimental setups and data interpretation methods on the measured ionic conductivities of solid polymer electrolytes (SPEs). SPEs were prepared using a polymer-induced phase separation process, resulting in a bi-continuous microstructure for improved ionic transport. Eight experimental rigs were evaluated, including two- and four-electrode setups with materials like stainless steel, copper, and aluminum. Ionic conductivity was assessed using electrochemical impedance …

Stratgies Used By Small Fashion Retail Business Leaders To Survive Beyond 5 Years, Lakeshia Nicole Chaney

Walden Dissertations and Doctoral Studies

Small fashion retail business leaders face survival challenges due to rapidly shifting consumer spending patterns and growing demands for social responsibility. The leaders care deeply about addressing these challenges to maintain profitability, protect jobs, and ensure sustainable growth in an increasingly competitive market. Grounded in strategic contingency theory, the purpose of this qualitative pragmatic inquiry study was to explore strategies small fashion retail business leaders use to survive beyond 5 years in South Central United States. The participants were six small fashion business leaders from a retail sector entity who successfully implemented survival strategies for at least 5 years. Data …

The Generalized Anxiety Disorder 7-Item (Gad-7) Tool For Anxiety Screening, Nicholas Tindong

Walden Dissertations and Doctoral Studies

The staff education project aimed to address the gap in practice regarding the use of the Generalized Anxiety Disorder 7-item (GAD-7) screening tool at a psychiatric clinic. Approximately 40% of the clinic’s patients exhibited symptoms of generalized anxiety disorder (GAD), yet the nurses did not consistently use validated tools to assess anxiety severity, relying instead on unstructured clinical interviews. This inconsistency has resulted in delayed diagnoses and suboptimal patient care. The project sought to improve nursing staff's knowledge and confidence in using the GAD-7 tool through a structured education program guided by the following practice-focused question: Among nurses at a …

Perceptions Of Nurse Preceptor Program Structure, Process, And Outcomes, Shinto Thomas

Walden Dissertations and Doctoral Studies

Precepting is crucial in successfully onboarding nurses in healthcare organizations, yet challenges remain in ensuring effective preceptor development. Well-structured preceptor programs contribute to consistent and safe nursing practices, enhance job satisfaction and competency among new nurses, and improve preceptor effectiveness while minimizing turnover. This quality improvement Doctor of Nursing Practice (DNP) project evaluated a structured nurse preceptor program's structure, process, and outcomes, focusing on its impact on clinical and critical thinking skills development through enhanced training and support. A key gap in understanding the program’s effectiveness was the lack of outcome data. This study explored participants’ perceptions of the preceptor …

Relationship Between Adjunct Faculty Workplace Inclusion And Burnout In Online Universities, Allisson Kinkade

Walden Dissertations and Doctoral Studies

Online universities rely on adjunct faculty even though including them in institutional processes is challenging and might be related to burnout. The relationship between the level of workplace inclusion and burnout of adjunct faculty has not been investigated. The purpose of this quantitative study was to explore the relationship between the level of workplace inclusion and burnout of adjunct faculty at online universities, moderated by instructor age, gender, and the number of years teaching as an adjunct. The conservation of resource theory by Hobfoll was used as the theoretical framework. For this quantitative nonexperimental correlational research design, data from 104 …

Staff Education On Medication Nonadherence For Patients With Bipolar Disorder, Julius Chick Abam

Walden Dissertations and Doctoral Studies

Summary From both the literature and the staff observation in this private practice, bipolar disorder (BD) patients who do not comply with medication are at a higher risk of hospitalization and poor quality of life. The purpose of the project was to implement staff training focused on adherence strategies, including motivational interviewing and psychoeducation to improve medication adherence rates among BD patients. The project question was: Does providing an interactive education program using case studies improve staff knowledge and self-confidence? Different studies support the effectiveness of both psychoeducation and motivational interviewing in improving adherence and functionality in BD. An interprofessional …

Reducing Disparities In Breastfeeding Among African American Women Through Professional Support, Latonia Feagin

Walden Dissertations and Doctoral Studies

This project involved developing a toolkit and implementing a staff education program to increase provider self-efficacy and knowledge concerning breastfeeding, increase provider understanding of the importance of a toolkit for addressing the gap in breastfeeding among African American women, and increase the intention of providers to use the toolkit by a minimum of 20%. The clinic reported breastfeeding in only 21% of African American patients, attributing this mainly to provider lack of breastfeeding self-efficacy and knowledge. It is essential for providers to deliver evidence-based, culturally sensitive breastfeeding information. This project involved evaluating provider self-efficacy, knowledge, understanding the importance of a …

Impact Of Medication Adherence On Patients With Bipolar Disorder, Vero Lum Fon

Walden Dissertations and Doctoral Studies

This staff education project was aimed at improving registered nurses’ (RNs) knowledge on the impact of medication adherence in patients with bipolar disorder. Up to 60% of patients fail to take their prescriptions as recommended, which increases the risk of recurrence and hospitalization and lowers quality of life. The practice-focused question is: Does comprehensive and targeted staff education improve knowledge of healthcare professionals regarding how to optimize medication adherence among patients diagnosed with bipolar disorder? I sought to provide RNs with evidence-based medication adherence and patient care measures to close the knowledge gap. Pre and post-tests were used to assess …

Therapists’ Experiences In Cases Of High-Conflict Divorce Among Individuals With Personality Issues, Tamara Soal

Walden Dissertations and Doctoral Studies

High-conflict divorce (HCD) involves prolonged conflict exceeding 2 years, persistent hostility, and extensive court involvement. Mental health professionals often participate as court-appointed expert witnesses or provide therapy at parental request. Therapists' roles become more complex when parents exhibit challenging personality traits. This descriptive qualitative study explored therapists’ experiences in treating children and families in HCD cases where one or both parents displayed complex personality issues or disorders. Greenberg and Gould’s model on mental health professionals in court cases and Freud’s countertransference theory provided the study’s conceptual framework. Data were collected through semistructured interviews with nine therapists, and thematic analysis was …

The Role Of Leadership In Improving Discharge Planning For Complex Cases In A Healthcare System, Philmaris Miranda Rodriguez

Walden Dissertations and Doctoral Studies

Behavioral health organizations face significant challenges in managing psychiatric hospital readmissions, often influenced by social determinants of health (SDOH) such as poverty, education, social support, housing, and food security. This study examines the perspectives of behavioral health leadership on discharge planning in psychiatric hospitals in the southeastern United States, exploring how leadership strategies impact patient readiness for discharge and reduce the risk of readmission. Using the Baldrige Performance Excellence Framework, key performance categories, including leadership, strategy, measurement, and operations, were evaluated to inform actionable improvements in discharge planning and transitional care. Evidence was collected through interviews with healthcare leaders and …

Physical And Mental Health Experiences Of Obese Men Living In The United States During The Covid-19 Pandemic, James Cunningham

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic posed unprecedented challenges to public health worldwide, significantly impacting vulnerable populations like obese men in the United States. This qualitative descriptive study involved exploring how these men perceived the pandemic’s impact on their physical and mental health, addressing a critical gap in existing literature. The research question that guided this study was: How did obese men living in the United States perceive the stressor that was the COVID-19 pandemic on their physical and mental health? Guided by the biopsychosocial model, the study involved using semi-structured interviews with 15 participants who were recruited online through social media. Thematic …

Teachers’ Instructional Strategies In Teaching English Language Learners English Writing In A Dual Language School, Courtney Mae Henson

Walden Dissertations and Doctoral Studies

It is the responsibility of educators to provide quality instruction for all students, including English language learners,. The problem that was addressed through this study is that teachers at Missionary Elementary School were struggling to implement appropriate instructional practices when teaching English writing to English language learners (ELLs) enrolled in a dual language program. The purpose of this study was to examine the instructional methods and to understand the support and/or resources needed for teachers to be successful. The writing observation framework provided the conceptual framework that guided this research. Data for this qualitative case study were collected through observations …

Training Needs Of Pre-Kindergarten To Second Grade General And Special Education Teachers To Include Students With Autism Spectrum Disorder, Rosana Camargo

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study is that general and special education teachers are not trained to include pre-kindergarten (Pre-k) through second grade students with autism spectrum disorder (ASD) in general education classrooms. The purpose of this study was to explore the training the teachers requested when including Pre-k through second grade students with ASD. The study was grounded by Vygotsky’s theory of the zone of proximal development. For this basic qualitative design, semistructured interviews were conducted with five general education and five special education teachers who teach in an inclusion setting. Both the general education and special …

Experiences Of Former Foster Youths With Learning Disabilities Who Transitioned Into Adulthood, Phyllis J. Phillips

Walden Dissertations and Doctoral Studies

Foster youths with learning disabilities face numerous challenges as they transition out of care, including housing instability, unemployment, and mental health issues. Despite these barriers, research focusing on this specific population is limited. Guided by Taormina’s adult personal resilience theory, this qualitative case study explored the experiences and perceptions of former foster youths with learning disabilities to inform interventions and improve service delivery and policy improvements. The research questions addressed the experiences of former foster youths with learning disabilities transitioning out of care, the unique challenges associated with transitioning out of foster care as experienced by former foster youths with …

Allostatic Load And Incident Dementia Among Older Adults In The United States, Mohammed Usman Kabeto

Walden Dissertations and Doctoral Studies

Allostatic load (AL), the cumulative physiological burden of chronic stress, is a significant health problem, and it has been associated with adverse health outcomes, including cognitive functioning. There is a paucity of literature examining associations between AL and incident dementia in the United States. This quantitative study used data from the United States Health and Retirement Study cohort (2016-2020) to examine the association between AL quartile and incident dementia among participants who were aged 56 and older at baseline. Dementia status was determined measuring immediate and delayed recall, serial seven subtraction, and backward count, as well as self-report conditions for …

4h Traveling Art Show Packet Strafford And Rockingham County, Caitlin Wollack

UNH Cooperative Extension

No abstract provided.

Deacon John C. Lockett, Sr.

African American Funeral Programs

No abstract provided.

The Potential Of Using Screening Tools For Bipolar Disorder To Predict Lithium Response, Ester Maria Marzo, Greta Sfratta, Guglielmo Donofrio, Alexia Koukopoulos, Giovanni Camardese, Alessio Simonetti, Lorenzo Moccia, Gianna Autullo, Gabriele Sani

Faculty, Staff and Students Publications

Background/Objectives: Lithium is the gold standard for treating Bipolar Disorder (BD), but its effectiveness varies widely. While clinical and environmental factors may influence response, it remains unclear if screening tools can reliably predict lithium response outcomes. This study explores this potential using two widely used screening instruments for BD.

Methods: A total of 146 patients with BD were evaluated. Lithium response was assessed using the Alda Scale, while hypomanic and manic symptoms were characterized through the Hypomania Checklist-32 (HCL-32) and the Mood Disorder Questionnaire (MDQ). Group differences in HCL-32 and MDQ scores were analyzed using ANOVA, and a multivariate model …

Biguanides Antithetically Regulate Tumor Properties By The Dose-Dependent Mitochondrial Reprogramming-Driven C-Src Pathway, Sukjin Yang, Kuldeep S Attri, Songyeon Ahn, Divya Murthy, Tagari Samanta, Debasmita Dutta, Meron Ghidey, Somik Chatterjee, Seung Yeop Han, Diego A Pedroza, Abha Tiwari, Joyce V Lee, Caitlin Davis, Shuting Li, Vasanta Putluri, Chad J Creighton, Nagireddy Putluri, Lacey E Dobrolecki, Michael T Lewis, Jeffrey M Rosen, José N Onuchic, Andrei Goga, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (BC) after metformin therapy. Considering that FAO can activate Src kinase in aggressive triple-negative BC (TNBC), we postulate that low-dose biguanide-driven AMPK-ACC-FAO signaling may activate the Src pathway in TNBC. The low bioavailability of metformin in TNBC xenografts mimics metformin's in vitro low-dose effect. Pharmacological or genetic inhibition of FAO significantly enhances the anti-tumor properties of biguanides. Lower doses of biguanides induce and higher doses suppress Src …

Cover And Forewords, C. Nicholas Raphael

The Geographical Bulletin

Cover and Forewords

The Geography Of The European Dreadnought Race: 1884-1919, William D. Walters, Jr.

The Geographical Bulletin

The launching of HMS Dreadnought in 1906 is sometimes regarded as the start of the warship building race preceding World War One and is often seen as one of the causes of that war. In fact, the European battleship building race goes back to the 1880s. Most of the countries of Europe participated in some way in this race, which involved significant transfer of technology from the more developed to the less developed countries of Europe. Spain, Italy and Russia received significant aid from armaments firms in northern and western Europe. During the period before the war, battleships dominated naval …

Volume 34-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 34-1 Complete Issue