Digital Commons Network^™

Role Of Autophagy In The Response Of Hs578t Breast Tumor Cells To Radiation, Shweta Chakradeo

Theses and Dissertations

Breast cancer is the most commonly observed cancer type in women and is the second leading cause of cancer death in women. Radiation can be used to debulk tumors prior to surgery as well as to treat patients after surgery and/or chemotherapy. Previous studies from our laboratory have shown that the anti –malarial drug chloroquine sensitizes breast cancer cell lines to radiation by suppression of autophagy which is a conservative catabolic process that can be cytoprotective. The scientific literature has demonstrated that many tumor cell systems undergo cytoprotective autophagy and that pharmacological or genetic inhibition of autophagy leads to other …

Nichole Medical Equip & Supply V. Tricenturion

2012 Decisions

USDC for the Eastern District of Pennsylvania

Erick Oliva Ramos V. Atty Gen Usa

2012 Decisions

Agency

Jean Coulter V. Allegheny County Bar Associati

2012 Decisions

USDC for the Western District of Pennsylvania

Usa V. Kwame Thomas

2012 Decisions

USDC for the Eastern District of Pennsylvania

Mill Bridge V Inc V. I. Benton

2012 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Harold Fitzgerald

2012 Decisions

USDC for the District of Delaware

The Eastern Echo, September 13, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

The Eastern Echo, September 13, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Testimony Of Mary Spector On Examining The Uses Of Consumer Credit Data Before Subcommittee On Financial Institutions And Consumer Credit Committee On Financial Services, Mary B. Spector

Faculty Journal Articles and Book Chapters

No abstract provided.

Vista: September 13, 2012, University Of San Diego

USD Vista (1965-)

No abstract provided.

Speaker Discusses Human Cost Of Immigration Policy, Kim Hill

News and Events (Discontinued Series)

No abstract provided.

Immortal Life Author: "Follow Your Curiosity", Tim Obermiller

News and Events (Discontinued Series)

No abstract provided.

Quantifying Performance Bias In Label Fusion, Alexander M. Venzin

Theses and Dissertations

Classification systems are employed to remotely assess whether an element of interest falls into a target class or non-target class. These systems have uses in fields as far ranging as biostatistics to search engine keyword analysis. The performance of the system is often summarized as a trade-off between the proportions of elements correctly labeled as target plotted against the number of elements incorrectly labeled as target. These are empirical estimates of the true positive and false positive rates. These rates are often plotted to create a receiver operating characteristic (ROC) curve that acts as a visual tool to assess classification …

The Diamond, September 13, 2012, Dordt College

Dordt Diamond

• Front Page: Tuition Goes up Five Percent for 2012-2013 Academic Year; Romney Speaks in Orange City About Job Creation
• News: From DENIS Stalking to DC Stalking; Dordt College Protests Contraception Mandate; Professor Jeff Taylor Represents Iowa at the Republican National Convention; Not Your Typical Registration; New Staff List
• Features: Student Jacob Richards Takes on NASA; International Introduction: Meet Jeremy Budi
• Opinion: Change; Liberation and Justice for All; Kids Say the Darndest Things!; Independent is the New Red... and Blue
• Sports: New Coaches, New Season, Same Outlook; Soccer Highlights; Ask an Athlete
• Arts and Entertainment: More Than a Musician: Dale Grotenhuis; …

Intelligent Behavioral Action Aiding For Improved Autonomous Image Navigation, Kwee Guan Eng

Theses and Dissertations

In egomotion image navigation, errors are common especially when traversing areas with few landmarks. Since image navigation is often used as a passive navigation technique in Global Positioning System (GPS) denied environments; egomotion accuracy is important for precise navigation in these challenging environments. One of the causes of egomotion errors is inaccurate landmark distance measurements, e.g., sensor noise. This research determines a landmark location egomotion error model that quantifies the effects of landmark locations on egomotion value uncertainty and errors. The error model accounts for increases in landmark uncertainty due to landmark distance and image centrality. A robot then uses …

Passive Synthetic Aperture Radar Imaging Using Commercial Ofdm Communication Networks, Jose R. Gutierrez Del Arroyo

Theses and Dissertations

Modern communication systems provide myriad opportunities for passive radar applications. OFDM is a popular waveform used widely in wireless communication networks today. Understanding the structure of these networks becomes critical in future passive radar systems design and concept development. This research develops collection and signal processing models to produce passive SAR ground images using OFDM communication networks. The OFDM-based WiMAX network is selected as a relevant example and is evaluated as a viable source for radar ground imaging. The monostatic and bistatic phase history models for OFDM are derived and validated with experimental single dimensional data. An airborne passive collection …

Utilizing Graphics Processing Units For Network Anomaly Detection, Jonathan D. Hersack

Theses and Dissertations

This research explores the benefits of using commonly-available graphics processing units (GPUs) to perform classification of network traffic using supervised machine learning algorithms. Two full factorial experiments are conducted using a NVIDIA GeForce GTX 280 graphics card. The goal of the first experiment is to create a baseline for the relative performance of the CPU and GPU implementations of artificial neural network (ANN) and support vector machine (SVM) detection methods under varying loads. The goal of the second experiment is to determine the optimal ensemble configuration for classifying processed packet payloads using the GPU anomaly detector. The GPU ANN achieves …

Effects Of Architecture On Information Leakage Of A Hardware Advanced Encryption Standard Implementation, Eric A. Koziel

Theses and Dissertations

Side-channel analysis (SCA) is a threat to many modern cryptosystems. Many countermeasures exist, but are costly to implement and still do not provide complete protection against SCA. A plausible alternative is to design the cryptosystem using architectures that are known to leak little information about the cryptosystem's operations. This research uses several common primitive architectures for the Advanced Encryption Standard (AES) and assesses the susceptibility of the full AES system to side-channel attack for various primitive configurations. A combined encryption/decryption core is also evaluated to determine if variation of high-level architectures affects leakage characteristics. These different configurations are evaluated under …

Creating Network Attack Priority Lists By Analyzing Email Traffic Using Predefined Profiles, Eric J. Merrit

Theses and Dissertations

Networks can be vast and complicated entities consisting of both servers and workstations that contain information sought by attackers. Searching for specific data in a large network can be a time consuming process. Vast amounts of data either passes through or is stored by various servers on the network. However, intermediate work products are often kept solely on workstations. Potential high value targets can be passively identified by comparing user email traffic against predefined profiles. This method provides a potentially smaller footprint on target systems, less human interaction, and increased efficiency of attackers. Collecting user email traffic and comparing each …

Ground Vehicle Navigation Using Magnetic Field Variation, Jeremiah A. Shockley

Theses and Dissertations

The Earth's magnetic field has been the bedrock of navigation for centuries. The latest research highlights the uniqueness of magnetic field measurements based on position due to large scale variations as well as localized perturbations. These observable changes in the Earth's magnetic field as a function of position provide distinct information which can be used for navigation. This dissertation describes ground vehicle navigation exploiting variation in Earth's magnetic field using a self-contained navigation system consisting of only a magnetometer and magnetic field maps. In order to achieve navigation, effective calibration enables repeatable magnetic field measurements from different vehicles and facilitates …

Investigation Into Suitability Of Geopolymers (Illite & Metakaolin) For The Space Environment, Brandon T. Cesul

Theses and Dissertations

Suitability of non-organic polymers for space application is studied. Materials included are illite and metakaolin. Bulk material suitability was investigated for exposure to ultraviolet radiation, atomic oxygen, and high energy charged particles. Outgassing phenomenon of the materials was studied. Curing shrinkage reduction techniques were identified as well.

Operationally Responsive Spacecraft Using Electric Propulsion, Thomas C. Co

Theses and Dissertations

A desirable space asset is responsive and flexible to mission requirements, low-cost, and easy to acquire. Highly-efficient electric thrusters have been considered a viable technology to provide these characteristics; however, it has been plagued by limitations and challenges such that operational implementation has been severely limited. The technology is constantly improving, but even with current electric propulsion, a spacecraft is capable of maneuvering consistently and repeatedly in low-Earth orbit to provide a responsive and flexible system. This research develops the necessary algorithm and tools to demonstrate that EP systems can maneuver significantly in a timely fashion to overfly any target …

Novel Discretization Schemes For The Numerical Simulation Of Membrane Dynamics, Kyle F. Kolsti

Theses and Dissertations

Motivated by the demands of simulating flapping wings of Micro Air Vehicles, novel numerical methods were developed and evaluated for the dynamic simulation of membranes. For linear membranes, a mixed-form time-continuous Galerkin method was employed using trilinear space-time elements, and the entire space-time domain was discretized and solved simultaneously. For geometrically nonlinear membranes, the model incorporated two new schemes that were independently developed and evaluated. Time marching was performed using quintic Hermite polynomials uniquely determined by end-point jerk constraints. The single-step, implicit scheme was significantly more accurate than the most common Newmark schemes. For a simple harmonic oscillator, the scheme …

The Characterization Of Material Properties And Structural Dynamics Of The Manduca Sexta Forewing For Application To Flapping Wing Micro Air Vehicle Design, Ryan P. O'Hara

Theses and Dissertations

The Manduca Sexta species of moth serves as a source of biological inspiration for the future of micro air vehicle flapping flight. The ability of this species to hover in flapping flight has warranted investigation into the critical material, structural, and geometric properties of the forewing of this biological specimen. A rigorous morphological study of the Manduca Sexta forewing was conducted to characterize the physical and material properties of the biological forewing for the purpose of developing an advanced parametric three dimensional model finite element analysis (FEA) model. This FEA model was tuned to match the experimentally determined structural dynamics …

The Multiobjective Average Network Flow Problem: Formulations, Algorithms, Heuristics, And Complexity, Jeremy D. Jordan

Theses and Dissertations

Integrating value focused thinking with the shortest path problem results in a unique formulation called the multiobjective average shortest path problem. We prove this is NP-complete for general graphs. For directed acyclic graphs, an efficient algorithm and even faster heuristic are proposed. While the worst case error of the heuristic is proven unbounded, its average performance on random graphs is within 3% of the optimal solution. Additionally, a special case of the more general biobjective average shortest path problem is given, allowing tradeoffs between decreases in arc set cardinality and increases in multiobjective value; the algorithm to solve the average …

Exploring The Dynamics And Modeling National Budget As A Supply Chain System: A Proposal For Reengineering The Budgeting Process And For Developing A Management Flight Simulator, Christoforos Kalloniatis

Theses and Dissertations

In the Science of Economics, there has been a debate about the optimal fiscal and budgetary policy that should be implemented by governments. On the one side, the advocates of the Keynesian Theory assert that in recession times governments should run budgets with deficits, in order to stimulate the economy, while the supporters of the Balanced Budget Theory, on the contrary, underscores the need to reduce and even eliminate the budget deficits. However, previous experience shows that both theories often failed to accomplish their goals, because they underestimated a very sensitive parameter: national budgets are not just an estimate of …

Towards The Mitigation Of Correlation Effects In The Analysis Of Hyperspectral Imagery With Extension To Robust Parameter Design, Jason P. Williams

Theses and Dissertations

Standard anomaly detectors and classifiers assume data to be uncorrelated and homogeneous, which is not inherent in Hyperspectral Imagery (HSI). To address the detection difficulty, a new method termed Iterative Linear RX (ILRX) uses a line of pixels which shows an advantage over RX, in that it mitigates some of the effects of correlation due to spatial proximity; while the iterative adaptation from Iterative Linear RX (IRX) simultaneously eliminates outliers. In this research, the application of classification algorithms using anomaly detectors to remove potential anomalies from mean vector and covariance matrix estimates and addressing non-homogeneity through cluster analysis, both of …

Effective Measurement Of Reliability Of Repairable Usaf Systems, Louis J. Hogge

Theses and Dissertations

The USAF generally does not know the reliability of its fielded repairable systems. The reported metric, Mean Time Between Failure (MTBF), is too lagging to be actionable in the best case, and is not representative of actual system reliability in the worst case. This thesis investigates the statistical techniques for measurement and analysis of the reliability of fielded repairable systems, which are very different than nonrepairables. To frame the investigation, a comparison is made between the generally accepted definitions and metrics and those used across the US Air Force (USAF). Reliability can be analyzed in four context areas: reliability prediction …

Individual Resistance To Change, Jeffrey C. Sandusky

Theses and Dissertations

This thesis examines individual resistance to change and concludes that it is a constantly evolving process with many contributing factors. Defining resistance to change is a challenge within its own right. To account for the actions involved in change resistance is an even more complex undertaking. In this research, resistance to change is examined and explained using the influences of goals, participation, leadership effectiveness, and communication. These factors are expressed as the composition of what makes an individual resist or accept a change. Each of the four elements of resistance to change are examined independently and then synthesized into a …