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Reproducing And Analyzing The “Lost In The Middle” And “The Power Of Noise” Phenomenon In Retrieval-Augmented Generation, Kousik Samanta Jun 2026

Reproducing And Analyzing The “Lost In The Middle” And “The Power Of Noise” Phenomenon In Retrieval-Augmented Generation, Kousik Samanta

Master’s Dissertations

Retrieval-Augmented Generation has become the way to improve Large Language Models. They help with problems like knowledge and hallucinations. Recent studies show that these models still have limitations. One big problem is the “Lost in the Middle” phenomenon. Models can’t access information in the middle of contexts properly. Another counterintuitive observation is the “Power of Noise” paradigm, which suggests adding unrelated documents can actually make the generation better. We know these happen in extractive QA tasks, but we don’t know if they happen in tasks that need complex reasoning. This dissertation looks into how position and noise affect Long-Form Question …


Learning To See Lesions, Not Skin Tone: Counterfactual Multimodal Learning For Fair, Trustworthy, And Text-Free Dermatology Ai, Shivam Jangid Jun 2026

Learning To See Lesions, Not Skin Tone: Counterfactual Multimodal Learning For Fair, Trustworthy, And Text-Free Dermatology Ai, Shivam Jangid

Master’s Dissertations

Recent advances in deep learning have significantly improved the performance of automated skin lesion classification systems, enabling accurate detection of various dermatological conditions from medical images. Despite these achievements, concerns regarding fairness and generalization remain a major challenge for the deployment of such systems in real-world clinical settings. A key factor contributing to these challenges is the presence of bias in training datasets, particularly with respect to skin-tone representation. Most publicly available skin lesion datasets contain a disproportionate number of samples from individuals with lighter skin tones. As a result, deep learning models trained on these datasets often learn representations …


Adaptive Spectral Trust Gate For Physics- Constrained Operator Learning, Soham Chakraborty Jun 2026

Adaptive Spectral Trust Gate For Physics- Constrained Operator Learning, Soham Chakraborty

Master’s Dissertations

Physics-informed machine learning improves the plausibility, data-efficiency and generalization of surrogate models by injecting prior physical knowledge into the learning process. The current approaches can be broadly divided into two main categories: soft constraints, which add a physics residual to the training loss but guarantee nothing at inference time, and hard constraints, which project the model output onto the constraint set exactly but apply the projection uniformly to every part of the signal — including parts that are dominated by noise, discretization error, or model mismatch, where the idealized physics is not actually trustworthy. This dissertation proposes the Adaptive Spectral …


Deep Reinforcement Learning With Directed Asymmetry And Kolmogorov-Arnold Networks For Dismantling Interdependent Multiplex Networks, Soumyajit Dev Jun 2026

Deep Reinforcement Learning With Directed Asymmetry And Kolmogorov-Arnold Networks For Dismantling Interdependent Multiplex Networks, Soumyajit Dev

Master’s Dissertations

Identifying the minimum-cost node-removal sequence that fragments a complex network - the network dismantling problem is NP-hard and central to infrastructure resilience. In interdependent multiplex networks, this difficulty is compounded by cascading cross-layer failures. While deep reinforcement learning (DRL) agents utilizing graph neural network (GNN) encoders achieve near-optimal dismantling, current state-of-the-art architectures suffer from two critical limitations. Topologically, existing agents strictly assume undirected edges, rendering them inapplicable to directed systems - such as supply chains or gene regulatory cascades - where failure propagation is fundamentally asymmetric. To resolve this, we propose Disassembling Directed Interdependent Networks (DDIN). DDIN introduces an asymmetric …


Cover And Contents Jun 2026

Cover And Contents

Turkish Journal of Physics

No abstract provided.


Direct Minimization Of Hartree-Fock-Roothaan Energy Functionals Using Derivative-Free Optimization Algorithms: A Case Study On The Use Of Noninteger Slater-Type Orbitals, Ali̇ Bağci Jun 2026

Direct Minimization Of Hartree-Fock-Roothaan Energy Functionals Using Derivative-Free Optimization Algorithms: A Case Study On The Use Of Noninteger Slater-Type Orbitals, Ali̇ Bağci

Turkish Journal of Physics

This study presents an evaluation of derivative-free optimization algorithms for the direct minimization of Hartree−Fock−Roothaan energy functionals involving nonlinear orbital parameters and noninteger-order quantum numbers. The analysis focuses on atomic calculations employing noninteger Slater-type orbitals. Analytic derivatives of the energy functional are not readily available for these orbitals. Four methods are investigated under identical numerical conditions: Powell’s conjugate−direction method, the Nelder−Mead simplex algorithm, coordinate-based pattern search, and a model-based algorithm utilizing radial basis functions for surrogate-model construction. Performance analysis is first carried out using the Powell singular function, a well-established test case exhibiting challenging properties, including Hessian singularity at the …


Usa V. David Loveings Jun 2026

Usa V. David Loveings

2026 Decisions

USDC for the Western District of Pennsylvania


Usa V. Brian Burrows Jun 2026

Usa V. Brian Burrows

2026 Decisions

USDC for the Eastern District of Pennsylvania


Antioxidant Potential Of A Non-Heme Iron Complex: Mitigating H2O2-Induced Cellular Damage, Magy A. Mekhail, David M. Freire, Cameron Bowers, Grant Elam, Nora Del Bosque, Hannah K. Pyle, Sarah K. Dunn, Spencer Lanyon, Timothy J. Hubin, Giridhar Akkaraju, Kayla N. Green Jun 2026

Antioxidant Potential Of A Non-Heme Iron Complex: Mitigating H2O2-Induced Cellular Damage, Magy A. Mekhail, David M. Freire, Cameron Bowers, Grant Elam, Nora Del Bosque, Hannah K. Pyle, Sarah K. Dunn, Spencer Lanyon, Timothy J. Hubin, Giridhar Akkaraju, Kayla N. Green

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Iron complexes with antioxidant activity have garnered significant interest for both general and medical applications, yet few studies have yielded functional nonheme iron-based mimics for H2O2 mitigation in aqueous environments. Here, we investigate water-soluble nonheme iron complexes derived from 12-membered pyridinophanes (CF3PyN3, PyN3, NMe2PyN3, and Py2N2) to evaluate the impact of ligand scaffolds on H2O2 decomposition activity both in vitro and in a cellular model. Speciation and kinetic analyses reveal that both electronic and geometric modulation of the macrocyclic …


Powerful Solar Storms May Change Weather Patterns Across North America, Rebecca Irelan Jun 2026

Powerful Solar Storms May Change Weather Patterns Across North America, Rebecca Irelan

UNH Today Archive

No abstract provided.


Pancreatitis Risk Genes Play A Major Role In Pediatric Pancreatitis: Insights From The International Study Group Of Pediatric Pancreatitis: In Search For A Cure, Maisam Abu-El-Haija, Wenying Zhang, Fuchenchu Wang, Gretchen Cress, Brian Dawson, Xiaoping Su, Tyler Thompson, Nicole Kotha, Ankur Chugh, Reuven Zev Cohen, Elissa M Downs, Douglas S Fishman, A Jay Freeman, Cheryl E Gariepy, Matthew J Giefer, Tanja Y Gonska, Phil Greer, Amit S Grover, Andrew Y J Liman, Douglas Lindblad, Quin Y Liu, Asim Maqbool, Jacob A Mark, Brian A Mcferron, Megha S Mehta, Veronique D Morinville, Kenneth Ng, Robert A Noel, Chee Y Ooi, Emily R Perito, Michael Wilschanski, Yuhua Zheng, Ying Yuan, David C Whitcomb, Aliye Uc, Mark Lowe, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc) Jun 2026

Pancreatitis Risk Genes Play A Major Role In Pediatric Pancreatitis: Insights From The International Study Group Of Pediatric Pancreatitis: In Search For A Cure, Maisam Abu-El-Haija, Wenying Zhang, Fuchenchu Wang, Gretchen Cress, Brian Dawson, Xiaoping Su, Tyler Thompson, Nicole Kotha, Ankur Chugh, Reuven Zev Cohen, Elissa M Downs, Douglas S Fishman, A Jay Freeman, Cheryl E Gariepy, Matthew J Giefer, Tanja Y Gonska, Phil Greer, Amit S Grover, Andrew Y J Liman, Douglas Lindblad, Quin Y Liu, Asim Maqbool, Jacob A Mark, Brian A Mcferron, Megha S Mehta, Veronique D Morinville, Kenneth Ng, Robert A Noel, Chee Y Ooi, Emily R Perito, Michael Wilschanski, Yuhua Zheng, Ying Yuan, David C Whitcomb, Aliye Uc, Mark Lowe, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Students Publications

Background & aims: Clinical data show that genetic variants are significant risk factors for acute recurrent pancreatitis and chronic pancreatitis. To expand the understanding of the role of genetics in acute recurrent pancreatitis and chronic pancreatitis, high-throughput next-generation sequencing of 14 genes was completed in a multicenter pediatric cohort.

Methods: A cross-sectional study involving 944 pediatric patients with acute recurrent pancreatitis or chronic pancreatitis was conducted. CASR, CEL, CFTR, CLDN2, CPA1, CTRC, GGT1, PRSS1, PRSS2, PRSS3, SBDS, SLC26A9, SPINK1, and UBR1 were sequenced. The frequencies of identified variants were compared with frequencies in the genome aggregation database. Group differences were …


Todd Walker's Legacy Bridges Decades Thanks To Teammate Award, Keith Testa Jun 2026

Todd Walker's Legacy Bridges Decades Thanks To Teammate Award, Keith Testa

UNH Today Archive

No abstract provided.


Easton White Contributes To The Un’S World Ocean Assessment, Mark Wanner Jun 2026

Easton White Contributes To The Un’S World Ocean Assessment, Mark Wanner

UNH Today Archive

No abstract provided.


University Of New Hampshire Dean's List For Spring 2026 Semester, Unh Communications And Public Affairs Jun 2026

University Of New Hampshire Dean's List For Spring 2026 Semester, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.


From Centrality To Sustainability: How Connected Boards Shape Waste Management Outcomes, Irfan Haider Shakri, Anh Tuan Nguyen, Fnu Pratima Jun 2026

From Centrality To Sustainability: How Connected Boards Shape Waste Management Outcomes, Irfan Haider Shakri, Anh Tuan Nguyen, Fnu Pratima

Faculty Publications

The escalating climate crisis has elevated waste management from an operational concern to a critical issue of corporate governance. However, the role of board connectedness in shaping firms' waste practices remains largely unexplored. Drawing on resource dependency and social capital theories, this study examines how board network centrality influences waste management practices. Employing pooled OLS on 4948 firm- year observations from US- listed firms during 2004–2023, we find that higher board connectedness leads to a significant reduction in waste generation. Economically, a one standard deviation increase in DEGREE centrality is associated with a 3.4% decrease in total waste generation. Our …


Always By The Seaside, Tony Gudkov Jun 2026

Always By The Seaside, Tony Gudkov

Intertidal

No abstract provided.


Analytical Eigenmode Framework For Triplet-Mediated Fluorescence Dynamics Under Pulsed Excitation, Bariş Demi̇rbay Jun 2026

Analytical Eigenmode Framework For Triplet-Mediated Fluorescence Dynamics Under Pulsed Excitation, Bariş Demi̇rbay

Turkish Journal of Physics

An exact analytical solution to a three-state photophysical model is presented to explicitly map the time-resolved fluorescence dynamics of a fluorophore under pulsed excitation. As distinct from earlier analytical treatments that primarily focused on transient absorption and total ground-state depletion, the proposed eigenvalue-eigenvector framework captures both transient and steady-state emission responses. The photophysical model accounts for electronic transitions between the singlet ground state, the excited singlet state and a long-lived triplet state, enabling a treatment of excitation, radiative decay, intersystem crossing, together with triplet-state relaxation. By diagonalizing the rate matrix consisting of phenomenological transition rates, closed-form expressions for the time-dependent …


Breaking The Ideal: Viscosity, Nonlinearity, And Transience In Wave Attractors, Stepan Elistratov, Ivan But Jun 2026

Breaking The Ideal: Viscosity, Nonlinearity, And Transience In Wave Attractors, Stepan Elistratov, Ivan But

Turkish Journal of Physics

Wave attractors in viscous media exhibit laminar or turbulent behavior, dictated by the intensity of the external forcing. Laminar attractors are often assumed to behave as linear systems. However, existing studies typically focus on fully developed flows, neglecting the dynamic formation process of these attractors. This simplification overlooks crucial transient phenomena that govern their emergence and stability. In this paper, first, we investigate unconventional wave attractor configurations subjected to forcing with a complex spectrum, which lead to early nonlinearity demonstration. Next, we focus on the transient processes of attractor formation and destruction, providing insights into their dynamic evolution. Furthermore, we …


Coupling A Discrete State To A Quasi-Continuum: A Model Quantum-Mechanical System That Interpolates Between Rabi Oscillations And Decay-Revival Dynamics, Enes Kutay İşgörür, Osman Cevheroğlu, Arkadaş Özakin Jun 2026

Coupling A Discrete State To A Quasi-Continuum: A Model Quantum-Mechanical System That Interpolates Between Rabi Oscillations And Decay-Revival Dynamics, Enes Kutay İşgörür, Osman Cevheroğlu, Arkadaş Özakin

Turkish Journal of Physics

We formulate a quantum-mechanical system consisting of a single discrete state coupled to an infinite ladder of equally spaced states, with the coupling described by a Lorentzian profile. Various limiting cases of this system correspond to well-known models in quantum optics: the narrow-resonance limit yields the Rabi model, the wide-resonance limit yields the Bixon--Jortner model, the wide-resonance true continuum limit yields the Wigner--Weisskopf model, and the fixed-resonance true continuum limit yields a system typically studied using methods developed by Fano. We obtain a semianalytical solution to the eigenvalue problem by reducing it to a transcendental equation and demonstrate the limiting …


Local Integrals Generating Exact Integrals Of Motion In Three-Dimensional Potential Fields: Part I, Fazliddin Shamshiev Jun 2026

Local Integrals Generating Exact Integrals Of Motion In Three-Dimensional Potential Fields: Part I, Fazliddin Shamshiev

Turkish Journal of Physics

The problem of identifying additional local integrals of motion in generic three-dimensional potentials remains a fundamental issue in dynamical systems and galactic dynamics, since most realistic gravitational fields lack global symmetries or separable coordinate systems. In this study, we propose a general constructive method for deriving such local integrals by introducing auxiliary functions whose gradients define an orthogonal frame adapted to the potential. The central idea is that the velocity field can be characterized by two quadratic algebraic relations whose compatibility conditions uniquely determine the orthogonal frame and ensure the existence of two additional isolating integrals. Our main results include: …


Isr 84 - Improving Documentation Accuracy Of Surgical Site Infection Prevention Bundles Using Implementation Science Frameworks, Laura Fraser, Lynn M. Sackett-Hodge, Michelle Schaeffer, Pamela S. Bozigar Jun 2026

Isr 84 - Improving Documentation Accuracy Of Surgical Site Infection Prevention Bundles Using Implementation Science Frameworks, Laura Fraser, Lynn M. Sackett-Hodge, Michelle Schaeffer, Pamela S. Bozigar

Conference Presentation Abstracts

Accurate documentation of Surgical Site Infection (SSI) prevention bundle components is essential for quality improvement and patient safety. In National Healthcare Safety Network (NHSN)-reported colon (COLO) and hysterectomy (HYST) procedures, incomplete or inconsistent documentation undermines bundle fidelity and limits evaluation of outcomes. This initiative aims to determine whether embedding evidence-based interventions within implementation science frameworks improves documentation accuracy and ensures sustainability.


If Pets Are Family: Pet Loss And The Need For Grief Equity In One Health, Michele L. Whitney Jun 2026

If Pets Are Family: Pet Loss And The Need For Grief Equity In One Health, Michele L. Whitney

Journal of One Health Systems

One Health frameworks increasingly recognize pets as integral to human health and well-being. However, these models often overlook the health and equity implications of pet loss. Culturally mediated grief experiences following pet bereavement represent a critical grief equity gap in One Health systems. Drawing on findings from a qualitative study of African American adults who experienced pet loss, along with existing literature, this Viewpoint highlights how pet loss is not only an emotional experience but also a socially structured one shaped by cultural norms, social recognition, and access to support. These dynamics contribute to inequities in how grief is experienced …


Manufactured Homes In The Mountain West, 2025, Yiselle Olivas Ruiz, Dre Boyd-Weatherly, Taylor Volk, Caitlin J. Saladino, William E. Brown Jr. Jun 2026

Manufactured Homes In The Mountain West, 2025, Yiselle Olivas Ruiz, Dre Boyd-Weatherly, Taylor Volk, Caitlin J. Saladino, William E. Brown Jr.

Housing & Real Estate

This fact sheet presents 2025 data on manufactured homes in the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The Construction Coverage report, “U.S. States Investing Most in Manufactured Homes,” based on analysis from the U.S Census Bureau and Zillow’s Home Value Index, includes data on all fifty states. This fact sheet focuses on the number of manufactured homes, site-built home permits, and the average price of manufactured homes in the Mountain West.


Multiple Organ Dysfunction Syndrome In Pediatric Colchicine Poisoning: A National Cohort Study From Türkiye, Faruk Eki̇nci̇, Di̇nçer Yildizdaş, Ozden Özgür Horoz, Hayri̇ Levent Yilmaz, Sevcan Bi̇len, İlker Ünal, İkbal Türker, Esra Şevketoğlu, Ni̇hal Akçay, Agop Çitak, Güntülü Şik, Tanil Kendi̇rli̇, Merve Havan, Murat Kangin, Mehmet Nur Talay, Nazi̇k Yener, Hati̇ce Albayrak, Edi̇n Botan, Utku Özer, Arzu Oto, Gürkan Bozan, Muhterem Duyu, Başak Nur Akyildiz, Nai̇me Gökay, Eli̇f Çeli̇k, Çapan Konca, Mutlu Uysal Yazici, Oğuz Dursun, Feyza İnceköy Gi̇rgi̇n, Hati̇ce Feray Ari, İlknur Arslan, Murat Özkale, Özlem Sandal, Merve Misirlioğlu, Hali̇l Keski̇n, Sadik Kaya, Arda Kilinç, Ferhat Sari, Fati̇h Akin, Ayşe Aşik, Ibrahi̇m Bi̇ngöl, Eda Turanli, Merve Boyraz, Ener Çağri Di̇nleyi̇ci̇, Mehmet Aki̇f Dündar, Selver Ceren Özcan, Aygül Kaya Akilli, Emi̇ne Akkuzu, Nazan Ülgen Tekerek, Ni̇lüfer Öztürk, Emrah Gün, Yasemi̇n Özkale, Nuretti̇n Onur Kutlu, Zeynelabi̇di̇n Öztürk Jun 2026

Multiple Organ Dysfunction Syndrome In Pediatric Colchicine Poisoning: A National Cohort Study From Türkiye, Faruk Eki̇nci̇, Di̇nçer Yildizdaş, Ozden Özgür Horoz, Hayri̇ Levent Yilmaz, Sevcan Bi̇len, İlker Ünal, İkbal Türker, Esra Şevketoğlu, Ni̇hal Akçay, Agop Çitak, Güntülü Şik, Tanil Kendi̇rli̇, Merve Havan, Murat Kangin, Mehmet Nur Talay, Nazi̇k Yener, Hati̇ce Albayrak, Edi̇n Botan, Utku Özer, Arzu Oto, Gürkan Bozan, Muhterem Duyu, Başak Nur Akyildiz, Nai̇me Gökay, Eli̇f Çeli̇k, Çapan Konca, Mutlu Uysal Yazici, Oğuz Dursun, Feyza İnceköy Gi̇rgi̇n, Hati̇ce Feray Ari, İlknur Arslan, Murat Özkale, Özlem Sandal, Merve Misirlioğlu, Hali̇l Keski̇n, Sadik Kaya, Arda Kilinç, Ferhat Sari, Fati̇h Akin, Ayşe Aşik, Ibrahi̇m Bi̇ngöl, Eda Turanli, Merve Boyraz, Ener Çağri Di̇nleyi̇ci̇, Mehmet Aki̇f Dündar, Selver Ceren Özcan, Aygül Kaya Akilli, Emi̇ne Akkuzu, Nazan Ülgen Tekerek, Ni̇lüfer Öztürk, Emrah Gün, Yasemi̇n Özkale, Nuretti̇n Onur Kutlu, Zeynelabi̇di̇n Öztürk

Turkish Journal of Medical Sciences

Background/aim: Colchicine poisoning has been associated with systemic toxicity, multiple organ dysfunction syndrome (MODS), and mortality. In the present study, the demographic, clinical, and laboratory characteristics of pediatric colchicine poisoning cases and the incidence of organ failure are investigated to identify potential risk factors associated with MODS.

Materials and methods: Included in this retrospective multicenter cohort study were pediatric patients admitted to 28 tertiary-care pediatric intensive care units with a diagnosis of colchicine poisoning. Demographic data, clinical and laboratory findings, and clinical outcomes were extracted from medical records. MODS was defined as dysfunction involving at least two organ systems. Multivariable …


Adding 3,4-Methylenedioxy-Α-Cyclohexylaminopropiophenone To A Standard Operating Procedure (Sop) For Identifying Synthetic Cathinones Using Gas Chromatography-Mass Spectrometry, Napassawon Timpratoom Jun 2026

Adding 3,4-Methylenedioxy-Α-Cyclohexylaminopropiophenone To A Standard Operating Procedure (Sop) For Identifying Synthetic Cathinones Using Gas Chromatography-Mass Spectrometry, Napassawon Timpratoom

ETDs from 2020-2029

Synthetic cathinones were identified as new psychoactive substances (NPS) in the early warning advisory system by the United Nations Office on Drugs and Crime (UNODC). Synthetic cathinones have been commonly referred to as bath salts, which offered “legal highs” because they were not explicitly scheduled. These compounds were detected dur-ing the screening process in casework and required internal validation for confirmation. 3,4-methylenedioxy-α-cyclohexylaminopropiophenone was the target analyte for this study. It was alternatively named N-cyclohexyl methylone and “cyputylone." The aim of the study was to validate 3,4-methylenedioxy-α-cyclohexylaminopropiophenone into a Standard Operating Procedure (SOP) for identifying synthetic cathinones using gas chromatography/mass spectrometry …


Cover And Contents Jun 2026

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.


Comprehensive Geriatric Assessment Identifies Multidimensional Vulnerabilities In Older Adults With Heart Failure, Ci̇han Kiliç, Rengi̇n Demi̇r, Özlem Yilmaz Aykent, Zerri̇n Yi̇ği̇t, Pinar Küçükdağli, Banu Özulu Türkmen, Güli̇stan Bahat, Mehmet Aki̇f Karan Jun 2026

Comprehensive Geriatric Assessment Identifies Multidimensional Vulnerabilities In Older Adults With Heart Failure, Ci̇han Kiliç, Rengi̇n Demi̇r, Özlem Yilmaz Aykent, Zerri̇n Yi̇ği̇t, Pinar Küçükdağli, Banu Özulu Türkmen, Güli̇stan Bahat, Mehmet Aki̇f Karan

Turkish Journal of Medical Sciences

Background/aim: Heart failure (HF) in older adults is frequently accompanied by geriatric syndromes that remain unrecognized in conventional cardiac evaluations. The vulnerabilities of older adults with and without HF in terms of muscle strength, physical performance, functional capacity, frailty, nutritional status, cognition, mood, anxiety, polypharmacy, and comorbidity were investigated using comprehensive geriatric assessment (CGA).

Materials and methods: A cross-sectional study was conducted in two academic outpatient clinics, enrolling 420 adults aged ≥60 years, including 92 (21.9%) with HF. Data included sociodemographic characteristics, anthropometric measurements, and CGA parameters: handgrip strength, the Five-Times Sit-to-Stand Test (FTSST), the Short Physical Performance Battery (SPPB), …


Clinical, Hormonal, And Treatment Outcomes In 247 Patients With Acromegaly: A Single Tertiary Center Experience, Ümran Gül, Beki̇r Uçan, Hayri̇ Bostan, Hakan Düğer, Hayri̇ Kertmen, Caner Ünlüer, Hali̇l Durantaş, Oğulcan Boz, Ceren Karaçalik Ünver, Burak Menekşe, Sema Hepşen, İlknur Öztürk Ünsal, Mustafa Özbek, Erman Çakal, Muhammed Kizilgül Jun 2026

Clinical, Hormonal, And Treatment Outcomes In 247 Patients With Acromegaly: A Single Tertiary Center Experience, Ümran Gül, Beki̇r Uçan, Hayri̇ Bostan, Hakan Düğer, Hayri̇ Kertmen, Caner Ünlüer, Hali̇l Durantaş, Oğulcan Boz, Ceren Karaçalik Ünver, Burak Menekşe, Sema Hepşen, İlknur Öztürk Ünsal, Mustafa Özbek, Erman Çakal, Muhammed Kizilgül

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the demographic, clinical, and hormonal characteristics; comorbidities; surgical pathology; treatment modalities; and long-term clinical outcomes of patients diagnosed with and managed for acromegaly at our tertiary referral center over a 15-year period.

Materials and methods: Between 2010 and 2024, 247 patients with acromegaly were evaluated. Diagnosis and biochemical remission were determined according to the 2024 Acromegaly Consensus Criteria.

Results: The median follow-up duration was 8 years (IQR: 3–14). At the time of diagnosis, the most frequent pituitary hormone deficiency was secondary adrenal insufficiency, present in 17.8% of patients. The most common comorbidities were hypertension …


Timing Of Kirschner Wire Removal In Pediatric Supracondylar Humerus Fractures: Is Early Removal A Safe And Effective Option?, Mustafa Kemal Yeni̇dünya, Si̇nan Yüksel, İbrahi̇m Faruk Adigüzel, Serhat Di̇nç, Önder Ersan Jun 2026

Timing Of Kirschner Wire Removal In Pediatric Supracondylar Humerus Fractures: Is Early Removal A Safe And Effective Option?, Mustafa Kemal Yeni̇dünya, Si̇nan Yüksel, İbrahi̇m Faruk Adigüzel, Serhat Di̇nç, Önder Ersan

Turkish Journal of Medical Sciences

Background/aim: The optimal timing of Kirschner wire removal following the surgical treatment of pediatric supracondylar humerus fractures remains controversial. This study aimed to compare the clinical and radiographic outcomes of early versus late K-wire removal and to contribute to the standardization of the timing of pin removal in pediatric patients.

Materials and methods: This retrospective study included 90 pediatric patients (aged 4–14 years) treated with closed reduction and percutaneous pinning for Gartland type III and IV supracondylar humerus fractures. Patients were grouped according to the timing of pin removal as early (postoperative days 21–28, n = 40) or late (after …


Bridging The Methodological Gap In Multitrauma Literature: A Competency-Based Educational Framework And Clinical Appraisal Filter, Şaki̇r Hakan Aksu, Burcu Doğan, Merve Yazla Jun 2026

Bridging The Methodological Gap In Multitrauma Literature: A Competency-Based Educational Framework And Clinical Appraisal Filter, Şaki̇r Hakan Aksu, Burcu Doğan, Merve Yazla

Turkish Journal of Medical Sciences

Background/aim: The statistical complexity of contemporary multitrauma literature has increased considerably in recent years, which may pose challenges for clinicians seeking to interpret high-impact research and apply evidence-based practices. Characterizing this methodological landscape and exploring education-oriented approaches may help to improve the interpretability of the literature and support informed clinical decision-making.

Materials and methods: A cross-sectional analysis was conducted on the 100 most-cited multitrauma studies published in Science Citation Index Expanded journals indexed in the Web of Science database between January 2018 and November 2025. The statistical methods used in each article were categorized into the three competency levels of …