Digital Commons Network^™

Senior Recital - Brooklynn Bowen, Brooklynn Bowen

All Music Department Programs

This recital is in partial fulfillment of the requirements for the degree of Bachelor of Music in Music Education.

Interactions Among Nutrients Govern The Global Grassland Biomass–Precipitation Relationship, Philip A. Fay, Laureano A. Gherardi, Laura Yahdjian, Peter B. Adler, Jonathan D. Bakker, Siddharth Bharath, Elizabeth T. Borer, W. Stanley Harpole, Erika Hersch-Green, George R. Wheeler

Michigan Tech Publications

Ecosystems are experiencing changing global patterns of mean annual precipitation (MAP) and enrichment with multiple nutrients that potentially colimit plant biomass production. In grasslands, mean aboveground plant biomass is closely related to MAP, but how this relationship changes after enrichment with multiple nutrients remains unclear. We hypothesized the global biomass–MAP relationship becomes steeper with an increasing number of added nutrients, with increases in steepness corresponding to the form of interaction among added nutrients and with increased mediation by changes in plant community diversity. We measured aboveground plant biomass production and species diversity in 71 grasslands on six continents representing the …

The Role Of Cholinergic Ventral Pallidum Cells In Effortful Motivation, Elizabeth A. Bien

Dartmouth College Ph.D Dissertations

Maladaptive reward-seeking behavior can be driven by one of several different components including excessive craving elicited by cues that predict rewards, failing to effortfully pursue rewards when it is beneficial to do so, and compulsively seeking rewards when it is no longer advantageous to do so. This thesis includes experiments focusing on these three different components of reward-seeking behavior to better understand how reward-seeking can become maladaptive. First, we wanted to examine the role that sex plays in the acquisition and compulsiveness of sign-tracking behavior in the Long Evans rat, a strain that is commonly used as the background for …

Exploring Rural Vs. Urban Variations In Emt Scope Of Practice: Advanced Airway And Iv Access Policies, Michaela Geffert

Theses

This thesis investigates how states across the United States (US) modify the Emergency Medical Technician (EMT) Scope of Practice (SoP) to permit advanced skills, with a focus on advanced airway management via supraglottic airways (SGAs) and intravenous (IV) access procedures, and whether rurality plays a role in these decisions. While the National EMS SoP Model establishes minimum competencies for each emergency medical services (EMS) provider level, individual states often alter their standards in response to local demographic, geographic, and resource-based needs. This study reviewed SoP policies from all 50 states, and 44 states were included. Logistic regression analysis was utilized …

Enhancing Oil Recovery With Novel Nano-Particle-Infused Surfactant Biopolymer Composite: A Comprehensive Investigation, Attia Attia, Amira Shafaay Dr., Michael Sami Alfonse Eng., George Azmi Eng., Rania Ramadan

Petroleum Engineering and Gas

The oil industry worldwide is searching for a new way to increase oil recovery. Chemical flooding has been used worldwide to improve oil recovery. In this research, the study of Enhanced Oil Recovery was carried out by using an Egyptian oil of API 42◦; the experiments were done by using Xanthan biopolymer (XG) gum with sodium dodecylbenzene sulfonate (SDBS) as a composite for the EOR process and studying the impact of different composite concentrations on oil recovery. Design Expert software was used to determine the optimum concentrations of the composite. 500 ppm concentration of graphene cobalt samarium ferrite nanoparticles (NP) …

Climate Data Imputation And Quality Improvement Using Satellite Data, Kadhim Hayawi, Sakib Shahriar, Hakim Hacid

All Works

Combating climate change has emerged as a global concern recently, and meteorological data remain an important measure for analyzing and predicting climate trends. However, ground weather stations and sensors can be impacted by faults due to accidents and unreliability, often resulting in, for example, missing data and lowering the overall quality of the data. This paper explores the impact of using satellite data as an input feature for machine learning algorithms. In particular, temperature, pressure, wind speed, and global horizontal radiation data are imputed using various machine learning algorithms to overcome potential data quality issues resulting from the ground stations. …

Characterization Of Long-Noncoding Rnas In Prostate And Pancreatic Cancer Through Single Cell Transcriptomics, Debanjan Saha

Arts & Sciences Graduate Student Theses and Dissertations

Metastatic castration resistant prostate cancer (mCRPC) is a subtype of prostate cancer that develops after metastasis and resistance to hormone therapy, thereby carrying a poor prognosis. Likewise, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies due to its propensity to present at advanced, unresectable stages in patients. Recent genomic studies have identified molecular features of mCRPC and PDAC, such as the existence of mutations in key driver genes, the extensive transcriptomic intra-tumoral heterogeneity, the role of regulatory elements in dictating driver gene expression, mechanisms of treatment resistance, and the interactions with the immunosuppressive and stromal tumor- microenvironment …

The Emotions Of Uncertainty: Science, Politics, And The Social Dynamics Of Decision Making, Alisa N. Rogers

Sociology ETDs

This dissertation examines how social and emotional factors influence attitudes toward science and decision making regarding science-based policy recommendations during the COVID-19 pandemic. I examine boundary work practices among the public as they evaluate experts during the pandemic and the social sources of information people used to construct knowledge. Then I examine the social and emotional factors that participants indicated influenced their own attitude formation and decisions to act regarding public health recommendations during the pandemic. I find that emotions influence each element of the decision process: information gathering, information evaluation, attitude formation, and decisions to act. Affective commitment and …

The Delocalized Toolbox: Tuning Strain, Energetic And Optoelectronic Properties Of Aryl Heterocyclic Scaffolds For Application-Driven Endeavors, Michael Josef Holzmann

Chemistry and Chemical Biology ETDs

This is a three-part dissertation. Part 1 is composed of chapters 1-3 which revolves around the optimization of cyclononyne reactivity towards 1,3 dipolar cycloadditions. Specifically, the synthesis and reactivity of sulfate, sulfamate and sulfamide-bearing cyclononynes will be discussed. Chapters 4-5 comprise Part 2 which addresses optimization of ruthenium olefin metathesis towards reversible activation and inhibition. The mechanism of reversible inhibition mediated by a hexaarylbiimidazole photo-inhibitor will be elucidated. Part 3 consists of chapters 6-8 which describes structure-functional relationship studies on carbon dots and harnessing that insight for sensing applications. Data relating to assays performed with explosive analytes will be analyzed …

Sharp Knives, Dark Hearts: Class, Colonialism, And Rebellion On Anthony Bourdain's Bookshelf, Carl Cactus Warmuth

American Studies ETDs

Though often characterized as a celebrity chef, Anthony Bourdain achieved stardom from his lively writing rather than skills in the kitchen. As such, the sociopolitical importance of his life and work is greatly illuminated by his compulsive literary references. Through George Orwell’s Down and Out in Paris and London, Émile Zola’s The Belly of Paris, Graham Greene’s The Quiet American, Joseph Conrad’s Heart of Darkness, and the personas of William S. Burroughs and Hunter S. Thompson, the tensions central to Bourdain’s legacy are unveiled. This thesis offers a portrait of Bourdain as a complicated figure of …

Nyls Blsa Students Illuminate And Inspire Pathways To Law, Jennifer Bancamper

NYLS Community News

No abstract provided.

An Investigative Analysis Into The Correlation Between Police Department Budgets And Violent Crime Rates., Julie Schwartz

Walden Dissertations and Doctoral Studies

Criminal justice reform and calls to defund the police have become more prevalent since the unrest that occurred in 2020. Research to date has looked at criminal justice reform, crime causation, and discussions surrounding defunding the police. Previous research has looked at police funding conceptually but not from a quantitative lens. The purpose of this quantitative nonexperimental study was to provide an investigative analysis into police department funding and the effect of the funding on violent crime rates using strain theory as its foundation. The research question addressed the relationship between police department budgets, specifically the criminal investigations unit, and …

The Experiences Of Veterans Seeking Peer-To-Peer Support For Mental Health Services After Covid-19, Edwin Brown

Walden Dissertations and Doctoral Studies

This qualitative study explored the experiences of U.S. military veterans seeking peer-to-peer support for mental health services after COVID-19. The study investigated how veterans perceive the role of peer-to-peer support in addressing mental health challenges, particularly in the context of social isolation, anxiety, and other COVID-19 related stressors. Using semi-structured interviews, data were collected from veterans who sought peer-to-peer support services after COVID-19. A total of 14 veterans participated in this study, providing insights into their experiences accessing and utilizing peer-to-peer support mental health services after COVID-19. Thematic analysis identified key themes, including the importance of shared lived experiences, the …

Funding Opportunities For Non-Profit Organizations Led By Black Women, Laquasha A. Dixon

Walden Dissertations and Doctoral Studies

This study addressed significant disparities in funding awarded to non-profit organizations (NPOs) in the United States, led by Black women. Racial bias and the lack of knowledge about alternative funding sources were key factors contributing to this funding gap, which limited the capabilities of these organizations. The research question guiding this study was: In addition to government grants and program sponsorships, what other funding sources are available to NPOs led by Black women? The conceptual framework employed as a foundation for the research was the concept of creating a diverse funding portfolio for sustainability. The purpose of the project was …

Fulltime Faculty Perspectives On Engagement In Distributed Leadership At A Technical College, Jacinda Halene Lay

Walden Dissertations and Doctoral Studies

The problem that was addressed in this basic qualitative study was that fulltime college faculty was not sufficiently engaged in distributed leadership at a technical college in a western state. The purpose of this study was to explore fulltime college faculty members’ perspective about their engagement in distributed leadership at a technical college in a western state. The research questions explored how fulltime faculty described their engagement in, and knowledge of, faculty leadership, at a technical college, and recommendations for increasing engagement. Using Spillane’s leader plus paradigm as the conceptual framework, semistructured interviews of 14 purposively sampled fulltime college faculty …

Relating Average Teacher Salary, Student-Teacher Ratios, And Percent Of Title I Schools To Teacher Retention Rates In Georgia School Districts, Deann Webb

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was high teacher turnover in Georgia school districts. Guided by the job demands-resources theory, the purpose of this quantitative, correlational study was to investigate average teacher salary, student-teacher ratios, and the percentage of Title I schools in terms of teacher retention rates in Georgia school districts. Archival data were collected from 180 public school districts in Georgia and obtained from the Georgia Department of Education and the Governor’s Office of Student Achievement. Multiple regression and Chi-square analyses were used to examine the relationships among variables. Chi-square analysis was used due to concerns …

Examining School Counselors’ Lived Experiences Of Relational Aggression In African American Girls, Crystal Holt

Walden Dissertations and Doctoral Studies

Since the early 1990s, there have been examinations of the predictors of Relational Aggression (RA) in girls, but many questions remain unanswered that contribute to the lived experiences of school counselors addressing RA. RA is best defined as behavior that is deliberate and unfriendly, with the intent to cause harm to others through verbal, social, and emotional control. The purpose of this study was to explore the lived experiences of school counselors addressing RA in African American girls. A hermeneutic phenomenological lens was used to examine the individual perceptions of eight school counselors. Semistructured interviews were used to gather the …

Higher Education Leaders’ Perspectives About Communication Challenges During Crises, Carey-Ann Marie Balkwill

Walden Dissertations and Doctoral Studies

The problem was that while impact and problems of crisis communication have been identified in the literature, little is known about the perspectives of leaders in higher education when facing communication issues in times of crisis. Guided by crisis communication theory and leadership theory, the purpose of this basic qualitative study was to explore higher education leadership team members’ perspectives of communication challenges in times of crisis. Four research questions guided the study on the perspectives of higher education leadership team members about (a) how their own leadership and communication changed during a crisis, (b) how internal communications evolved during …

Staff Education To Enhance Nurses' Knowledge Of Pressure Injury Prevention, Jacqueline Evette Foster

Walden Dissertations and Doctoral Studies

Summary Hospital-acquired pressure injuries (HAPIs) have a significant negative impact on patient safety and the quality of care. This doctor of nursing practice (DNP) staff education project focused on improving staff nurses’ knowledge in preventing pressure injuries. Recognizing the high incidence of pressure injuries at the project site, this staff education project addressed the critical need to reduce pressure injuries for at-risk patients by providing ongoing education and training to enhance pressure injury management, reduce hospital costs and length of hospitalization, and improve patient care quality. The practice-focused question guiding this staff education project was the following: To what degree …

K-12 Principals Who Persist In Their Principalship Despite Challenges In Urban Schools, Monique Nicole Durham

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study is the approximately 13% attrition of K-12 principals in a large urban school district in the Mid-Atlantic region, exceeding the national average. The purpose of this qualitative study was to explore the perspectives of K-12 principals who had persisted in their roles despite the significant challenges in leading urban schools. The study was grounded in the job demands-resources theory, which posits that job demands could lead to burnout, while job resources help employees cope with challenges, thereby fostering resilience. For this basic qualitative design, data were collected from semistructured interviews with 12 …

The Role Of Knowledge Of Vaping And E-Cigarette Use Among Young Adults Aged 18-25 Years, Martha Tarluwah Kollison

Walden Dissertations and Doctoral Studies

Vaping is a growing public health concern in the United States among young adults. Despite the belief that vaping is safer compared to traditional smoking, e-cigarettes have become a major public health problem among young adults between the age of 18-25 in the United States. In this qualitative study, the perceptions of the risks of vaping by young adults in Indiana, their lived experiences, and factors contributing to vaping behavior were explored. Based on the Health Belief Model (HBM), the effect of knowledge on perceived risks and reported vaping behavior among the respondents was explored. Ten participants, seven males, and …

A Survey Of Sampling Methods For Hyperspectral Remote Sensing: Addressing Bias Induced By Random Sampling, Kevin T. Decker, Brett J. Borghetti

Faculty Publications

Identified as early as 2000, the challenges involved in developing and assessing remote sensing models with small datasets remain, with one key issue persisting: the misuse of random sampling to generate training and testing data. This practice often introduces a high degree of correlation between the sets, leading to an overestimation of model generalizability. Despite the early recognition of this problem, few researchers have investigated its nuances or developed effective sampling techniques to address it. Our survey highlights that mitigation strategies to reduce this bias remain underutilized in practice, distorting the interpretation and comparison of results across the field. In …

Graphic Art & Revolution: One Woman's Experience, Margaret Randall

LAII Events

April 11, 2025 5:00-6:00 pm

University of New Mexico Art Museum

GRAPHIC ART & REVOLUTION:

One Woman's Experience

A lecture by Margaret Randall

Global And Regional Disparities In Access To Specialist Sarcoma Services, Tomas Zamora, Eduardo Botello, Thomas Jenkins, Charlotte Jeys, Minna Laitinen, Lee Jeys, Santiago Abad Repiso, Hesham Abdelbary, Alejandro Abiad Mejia, Ahmed Abood, Juan C Abril Martin, Adesegun Abudu, Ayman Abu Elhamd, Marthelena Acosta, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Ibrahim Alshaygy, Jose I Albergo, John Alexander, Patricio A Alfaro, Bugra Alpan, Jose Amaya-Valero, Megan Anderson, Dimosthenis Andreou, Lucas Annabell, Christopher Anthony, Ahmed Aoude, William Aston, Libe Asua Mentxaka, Christine Azzopardi, Thomas Baad-Hansen, Ismail T Badr, Francisco Baixauli-Garcia, Gavin Baker, Tessa Balach, Giacomo G Baldi, Janie Barry, Georges Basile, Stefano Bastoni, Mohammad H Basuki, Henrik Bauer, Lee Bayliss, Ricardo G Becker, Angad Bedi, Joseph Benevenia, Francisco Bengoa, Peter Bergh, Marko Bergovec, Nicholas Bernthal, Odion Binitie, David Boddie, Michele Boffano, Patricia Bonilla Huertas, Anna B Borgognoni, Rajesh Botchu, Richard A Boyle, Jos Bramer, Rahat Brar, Harriet Branford-White, Demien Broekhuis, Samuel E Broida, Tymoteusz Budny, Zachary D Burke, Jorge Cabrolier, Jose A Calvo-Haro, Jorge R Calvo-Tapies, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Pedro I Carvallo, Nicolas Casales Fresenga, Jose M Casanova, Oscar Ceballos, Juan L Cebrian Parra, Laura K Certain, Sara Chancon Cartaya, Chung M Chan, Yoon Joo Cho, Peter Choong, Yang-Guk Chung, David Ciechanowicz, David Clever, Sebastian Colina, Luis Consuegra, Cory Couch, Gillian Cribb, Carlos Cuervo, Laurence A Cusick, Solomon Dadia, Tanios Dagher, Dietmar Dammerer, Mark Davies, Nerys Davies, Luis P De La Rosa Martino, Francisco J De Santos De La Fuente, Marieke De Vaal, Claudia Deckers, Javier Delgado Obando, Shaneel Deo, Niklas Deventer, Claudia Di Bella, Gregory Domson, Davide M Donati, Desiree M Dorleijn, Jacques Du Toit, Debra Dunne, Rodolfo Duran Ciarrochi, Walid Ebeid, Elina Ekman, Ahmed M El Ghoneimy, Makoto Endo, Levent Eralp, Mahmoud Etaiwi, Scott Evans, Robin Evrard, Will Eward, Alberto Farese, Peter C Ferguson, Pedro F Ferreira Cardoso, Fabrice Fiorenza, Michael Flint, Hector Flores, Joao Freitas, Bruno Fuchs, Tomohiro Fujiwara, Philipp T Funovics, Marcos Galli Serra, Zakareya Gamie, Carlos Garces-Zarzalejo, Aaron Gazendam, Carsten Gebert, Jasper G Gerbers, Craig Gerrand, Ghaith Abou-Nouar, Michelle Ghert, Kanishka M Ghosh, Max Gibbons, Luis C Gomez-Mier, Jesus Gomez-Vallejo, Anne Gomez-Mascard, Marcos R Gonzalez, Fausto Gonzalez-Lizan, Georg Gosheger, Stuart Goudie, Krista Goulding, Stavros D Goumenos, Anthony Griffin, Ashish Gulia, Sanjay Gupta, Amit Gupta, Maurice Guzman, Mohammed Haitham, Jendrik Hardes, Francisco Hardoy, Yusuf Hasan, Georg Hauer, Helard Havard, Rex Haydon, John Healey, Nerea Hernandez Gonzalez, Adriana Hernandez-Lopez, Asle Hesla, Matthew Hess, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Matthew T Houdek, Eleanor Houghton, Oluwaseyi K Idowu, Joseph Ippolito, Marc Isler, Shintaro Iwata, Jake Jagiello, Neil Jenkins, Tom Jeys, Luke Johnson, Andy Johnston, Min Wook Joo, Paul C Jutte, Kadri Kaldas, Amar Kamat, Sudhir Kannan, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Vineet Kurisunkal, Richard Kyte, Jose M Lamo De Espinosa, Alexander L Lazarides, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Maryse Lejoly, Valerae O Lewis, Peng Lin, Francisco Linares, Santiago A Lozano-Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Fermin J Mandia Mancebo, Sara Martos Torrejon, Christian Marx, Eric Mascard, Jean-Camille Mattei, Louise Mccullough, Sam Mcmahon, Manuel R Medellin Rincon, Benjamin Miller, Shinji Miwa, Gustavo Molina Uribe, Bryan Moon, Thomas Hilton, Diego J Moriel Garcesco, Carol Morris, Guy Morris, Steward Morrison, Sophie Mottard, Marcio Moura, Linde Muster, Robert Nakayama, Prashant Narhari, Ana Navas, Prakash Nayak, Johannes Neugebauer, Erik T Newman, Jyrki Nieminen, Emmy Nyqvist, Lukas Nystrom, Sarah O'Reilly-Harbidge, Gary O'Toole, Vania Oliveira, André Olivier, Mohamed Omar, Eduardo J Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Elisa Pala, Emanuela Palmerini, Grant Pang, Panayiotis Papagelopoulos, Giovanni Paraliticci, Michael C Parry, Sam Patton, David Peake, Ana Peiro Ibanez, Israel Perez Munoz, Ganapathy R Perianayagam, Michael M Petersen, Joris Ploegmakers, Robin Pollock, Gerard Powell, Juan Pretell, Jan Puetzler, Faisal Qamar, Anand Raja, Raja B Rajasekaran, Dipak Ramkumar, R L Randall, Kenneth Rankin, Kevin A Raskin, Kumaran Rassppan, Lauris Repsa, Mickael Ropars, Peter Rose, Pietro Ruggieri, Wael Sadek, German Salcedo, Aasim Saleemi, Andrea Sambri, Hartej Sar, Roberto Scanferla, Thomas Schubert, Jan Schwarze, Guido Scoccianti, Ashley Scrimshire, Tetsuya Sekita, Ahmad Shehadeh, Ahmed Shoaib, Bhim Shreemal, Felix Shumelinsky, Geoffrey Siegel, Claudio Silveri, Robert Silverwood, Friedl Sinnaeve, Jerome Sison, Andrea Slade, Maria A Smolle, Franz Snyman, Scott Sommerville, Sahil Sood, Andre Spiguel, Hugo St-Yves, Eric L Staals, Silvia Stacchiotti, Nikolas Stavropoulos, Peter Steadman, Jonathan D Stevenson, Mikaela Sullivan, Gwen Sys, Bartlomiej Szostakowski, Angela Tamburini, Yuta Taniguchi, Thomas Temple, Christoph Theil, Joachim Thorkildsen, Meagan Tibbo, Roger Tillman, Yu Toda, Kaspar Tootsi, Ferran Torner-Rubies, Frank Traub, Ioannis Trikoupis, Panagiotis Tsagkozis, Kim Tsoi, Hiroyuki Tsuchiya, Veli-Matti Vainio, Antonio Valcarcel, Juan Valencia, Annelies Van Beeck, Michiel Van De Sande, Thomas Van Den Berghe, Ingrid Van Der Geest, Lizz Van Der Heijden, Robert Van Der Wal, Kirsten Van Langevelde, Gualter Vaz, Roberto Velez Villa, Floortje Verspoor, Koenraad Verstraete, Julia Visgauss, Oleg Vyrva, Hazem Wafa, Sebastian Walter, Wan F Wan Ismail, Edward Wang, Patrick Q Wang, David Warnock, Joel Werier, Wolfram Weschenfelder, Kwok-Chuen Wong, Marjan Wouthuyzen-Bakker, Jay Wunder, Indica Wysinghe, Norio Yamamoto, Zhaoming Ye, Seung-Jae Yoon, Suraya Zainul Abidin, Pierluca Zecchetto, Liuzhe Zhang, Juan P Zumarraga, Miguel A Clara-Altamirano

Faculty, Staff and Student Publications

Aims: Cancer care guidelines have been developed in many subspecialities, usually in advanced health systems. However, there are notable global disparities in healthcare access, which can impact sarcoma care. Unfortunately, there is a lack of global data on this subject. Our aim was to describe access to sarcoma care based on a comprehensive global survey among orthopaedic oncologists, and assess for global as well as regional differences.

Methods: A 25-question survey was emailed to the attendees of the 2024 Birmingham Orthopaedic Oncology Meeting and included questions about the respondents' training and practice, access to sarcoma centres, and specific items for …

Natural Killer Cells’ Functional Impairment Drives The Immune Escape Of Pre-Malignant Clones In Early-Stage Myelodysplastic Syndromes, Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Bijender Kumar, Natthakan Thongon, Feiyang Ma, Yi J Kim, Sanam Loghavi, Roselyn Tan, Vera Adema, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Gheath Al-Atrash, Rafael Bejar, Pinaki Prosad Banerjee, Sophia Lynn Cha, Guillermo Montalban-Bravo, Max Dougherty, Maria Claudina Fernandez Laurita, Noelle Wheeler, Baosen Jia, Eirini P Papapetrou, Franco Izzo, Daniela E Dueñas, Salome Mcallen, Yiqian Gu, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Abhinav Jain, Koichi Takahashi, Karen Clise-Dwyer, Stephanie Halene, Maria Teresa Sabrina Bertilaccio, Guillermo Garcia-Manero, May Daher, Simona Colla

Faculty, Staff and Student Publications

Dissecting the preneoplastic disease states' biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem cells (HSCs), most of which are mutated by the time of diagnosis. Here, we sought to elucidate how MDS HSCs evade immune surveillance and expand in patients with clonal cytopenias of undetermined significance (CCUS), the pre-malignant stage of MDS. We used multi-omic single-cell approaches and functional in vitro studies to show that immune escape at disease initiation is …

Histone H3 Cysteine 110 Enhances Iron Metabolism And Modulates Replicative Life Span In Saccharomyces Cerevisiae, Chen Cheng, Brenna S Mccauley, Nedas Matulionis, Maria Vogelauer, Dimitrios Camacho, Heather R Christofk, Weiwei Dang, Nicholas A T Irwin, Siavash K Kurdistani

Center on Aging Staff Publications

The discovery of histone H3 copper reductase activity provides a novel metabolic framework for understanding the functions of core histone residues, which, unlike N-terminal residues, have remained largely unexplored. We previously demonstrated that histone H3 cysteine 110 (H3C110) contributes to cupric (Cu2+) ion binding and its reduction to the cuprous (Cu1+) form. However, this residue is absent in Saccharomyces cerevisiae, raising questions about its evolutionary and functional significance. Here, we report that H3C110 has been lost in many fungal lineages despite near-universal conservation across eukaryotes. Introduction of H3C110 into S. cerevisiae increased intracellular Cu1+ levels and ameliorated the iron …

Cover

Louisiana Law Review

No abstract provided.

Characterization Of Fibrotic Liver Tissue Microstructure For Predicting Shear Wave Speed Variability: A Machine-Learning-Based Computational Study, Emily J. Miller, Yongmei M. Jin, Jingfeng Jiang

Michigan Tech Publications

Objective: This study aimed to establish a link between the microstructure of simulated fibrotic liver tissues and the measured shear wave speed variability using a machine-learning-based approach. Approach: Fibrotic liver tissues were simulated using biphasic random fields. The underlying microstructure of the simulated fibrotic liver pathology (sFLP) was characterized using spatial pattern distribution analysis.A machine learning (ML) technique was implemented to identify top-rated spatial characteristic (SC) features and provide context for shear wave speed (SWS) variability, ultimately enabling us to use the SWS variability to infer its underlying tissue microstructure. Different combinations of top-three features were tested to understand the …

Local Nutrient Addition Drives Plant Diversity Losses But Not Biotic Homogenization In Global Grasslands, Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew Macdougall, Erika Hersch-Green, Et Al.

Michigan Tech Publications

Nutrient enrichment typically causes local plant diversity declines. A common but untested expectation is that nutrient enrichment also reduces variation in nutrient conditions among localities and selects for a smaller pool of species, causing greater diversity declines at larger than local scales and thus biotic homogenization. Here we apply a framework that links changes in species richness across scales to changes in the numbers of spatially restricted and widespread species for a standardized nutrient addition experiment across 72 grasslands on six continents. Overall, we find proportionally similar species loss at local and larger scales, suggesting similar declines of spatially restricted …

Impacts Of Riverine Heatwaves On Rates Of Ecosystem Metabolism In The United States, Spencer J. Tassone, Michelle Kelly, Olivia N. Beidler, Michael L. Pace, Amy Marcarelli

Michigan Tech Publications

Rivers produce and decompose large amounts of carbon globally due, in part, to high rates of gross primary production (GPP) and ecosystem respiration (ER), collectively known as ecosystem metabolism. Water temperature is a major driver of ecosystem metabolism, and in-stream temperatures are increasing globally, including extreme temperature events called heatwaves. This study used published estimates of daily GPP and ER from 48 stream and river locations in the United States to examine how ecosystem metabolism responds to riverine heatwaves. During low-severity heatwaves, GPP and ER increase proportionally, resulting in no net difference. However, during severe and extreme heatwaves, GPP declined …