Digital Commons Network^™

Psychrotrophic Antarctic Marine Bacteria As Potential Reservoirs For Novel Antimicrobial Genes, Kudzai Hwengwere, Grant G. January, Kerry L. Howell, Lloyd S. Peck, Mathew Upton, Melody S. Clark

School of Biomedical Sciences

Antarctica is a very cold, isolated continent surrounded by frozen seas, yet these extreme environmental conditions have not restricted life and diversity in the sea. The marine environment is seasonally highly productive and harbours diverse and abundant communities of organisms, with many endemic species occurring nowhere else in the world. Such communities and their associated microbiomes are increasingly recognized as an unexplored source of novel antimicrobial products. Hence, the major aim of this study was to examine the antimicrobial potential of bacteria cultured from eight Antarctic marine invertebrate species, while gathering data on Antarctic microbial thermal and salinity tolerances. All …

Fact Sheet For Parents: What To Know About Zyn Nicotine Pouches, Aaron Hunt, Gabriela Murza, Alyssa Ferrin

All Current Publications

This fact sheet provides information about ZYN, which is a nicotine pouch becoming commonly used among youth due to social media advertising. This fact sheet will help parents understand the impact of ZYN pouches and approaches to monitor, prevent, and address use among youth.

Supporting Health Equity In Obesity Prevention For Women Of Reproductive Age, Amanda Gilbert

Brown School Graduate Student Theses and Dissertations

Women of reproductive age (18-44 years) are at an increased risk of developing obesity due to pregnancy, stressors during this stage in the life course (e.g., leaving home, new jobs, parenthood), and historical and ongoing discrimination and marginalization. Preventing obesity for this population needs to be a public health priority. Obesity negatively affects women’s health (e.g., chronic disease, cancer); leads to poor pregnancy outcomes (e.g., gestational diabetes); and increases the risk children will develop obesity through intergenerational transmission of obesity, further entrenching health disparities for future generations. Health equity principles of social justice and human rights help obesity prevention researchers …

Library Data Storytelling And Information Wisdom, Kate Mcdowell

Bryant Jackson Lectureship

What can you tell about your library data as a story? Learn how to bring data stories to life for library advocacy of all types, from sustaining the library to transforming its work. Participants will learn about ongoing research identifying classic library stories told to persuade decision-makers as part of the Data Storytelling Toolkit for Libraries project (IMLS). Tools academic libraries can use include:

• Strategies to understand data storytelling uses for academic libraries
• Reach different kinds of audiences such as students, administrators, and funders
• Adapt narrative structures to communicate information and emotion at the same time

Dr. Kate McDowell’s interdisciplinary …

On The Nature Of Things: Communication And Relationships, The Philosophical Discussion Group

The Philosopher's Stone

• On the Nature of Things: Communication and Relationships

Ute Mri For Assessing Demyelination In An Mtbi Mouse Model: An Open-Field Low-Intensity Blast Study, Yajun Ma, Qingbo Tang, Xin Cheng, Jiyo S. Athertya, David Coughlin, Eric Y. Chang, Catherine E. Johnson, Jiankun Cui, Zezong Gu, Jiang Du

Mining Engineering Faculty Research & Creative Works

Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to assess demyelination in mice with mTBI induced by open-field low-intensity blast (LIB) using a novel three-dimensional short repetition time adiabatic inversion recovery UTE (3D STAIR-UTE) magnetic resonance imaging (MRI) sequence. Thirty male C57BL/6 mice, with 15 experiencing mTBI and 15 serving as sham controls, were included in this study. Behavioral tests were performed starting at 5 days post-injury to assess motor activity and anxiety-like responses followed by STAIR-UTE …

Numerical Simulation Of Heat Transfer In Self-Propagating High-Temperature Synthesis (Shs)-Based Calcination Of Limestone, Sayee Srikarah Volaity, Shubham Agrawal, Srinivas Kilambi, Patrick Phelan, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Calcination of limestone, a high temperature (∼900 °C) process that emits 44 % of the mass of limestone as CO₂, is a critical process in the production of many industrially important materials. To soften the CO₂-related impacts of traditional calcination, and to enable ultrafast synthesis of lime, a novel approach based on self-propagating high-temperature synthesis (SHS) has been put forward. SHS uses exothermic heat released by the combustion of fuel intermixed with the reactants to advance the reaction, and hence requires the provision of lower external temperatures. This study introduces a microstructure-guided modeling approach to understand …

Building Wealth One Sentence At A Time: A Capitalist’S Guide To Criminal Justice, Alexandra J. Lindell

Masters Projects

This project explores the underutilized profit potential of criminal justice in the United States. Its systemic design and aggressive market positioning have made long-term success possible. Nevertheless, this is just the beginning; there are new revenue streams to unlock and untapped markets to capture. Using a mixed-methods approach, the research identifies key historical policies, how collateral consequences contribute to customer retention and acquisition, and current barriers to profit maximization. The findings emphasize the importance of a coordinated, multi-level strategy involving lawmakers, media, corporations, and private stakeholders to protect and expand revenue streams, manipulate public perception, and disrupt reform efforts. By …

Rose Receives Award For Excellence In Academic Service Unit, Communications And Marketing

Campus News Archive

No abstract provided.

Tollefsrud To Give Student Address At Umn Morris Commencement, Communications And Marketing

Campus News Archive

No abstract provided.

Introducing 'Society Work': The Professionalization And Localization Of Chinese Social Work In A New Era, Ke Cui, Timothy Sim, Chenxi Huang, Bowen Mcbeath

School of Social Work Faculty Publications and Presentations

This study focuses on current discussions around the newly-built Society Work Department in China. It argues that ‘society work’ helps to clarify the internationally recognized concept of ‘social work’ and this institutional reform promotes development of the social work profession and discipline, it also helps to decolonize social work in China.

Navajo Speech Recognition Using Low-Resource Language Models, Emery M. Sutherland

Electrical and Computer Engineering ETDs

This thesis describes the development of a speech recognition system to classify Navajo (Dine) words using Low Resource Language (LRL) datasets. Presently there are no recognized high-quality open-sourced datasets for the Dine language needed to train models for speech recognition. A small balanced dataset was designed to train several models. To overcome the scarcity of the LRL dataset, the audio recordings were augmented to account for time-stretching, amplitude variations, time shifts, small amounts of white Gaussian noise, and SpecAugmentation. The models included a Recurrent Neural Network (RNN), a Convolutional Neural Network (CNN), and a Long Short-Term Memory (LSTM) model with …

Continuous Purification Of A Parvovirus Using Two Aqueous Two-Phase Extraction Steps, Natalie Nold, Sheridan Waldack, Grace James, Trisha Colling, Lynn M. Manchester, Taravat Sarvari, Amanda P. Bekkala, Seth Kriz, Madison Baldwin, Emily Agustin-Mazariegos, Michael J. Betenbaugh, Caryn Heldt

Michigan Tech Publications

Aqueous two-phase systems (ATPS) are a liquid–liquid extraction method that offers low-cost, continuous-adaptable virus purification. A two-step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run continuously. The continuous system output of < 10 ng/mL DNA regardless of starting DNA titer agreed with batch studies. However, the continuous system had a five-fold higher contaminating protein titer than batch studies, likely because of incomplete mixing or settling. Turbidity was tested as a measure of mixing and settling efficiency. Monitoring in-line absorbance at 880 nm directly after mixing and before collection in the settling reservoir could track both mixing and settling during operation. Settling time was reduced by changing the settling line material from PVC to PTFE, which is more hydrophobic. A flow-through AEX filter tested to make impurity removal more robust recovered 90% of PPV and removed an additional 87% of host cell DNA. The filter did not add any additional protein removal. In the future, in-line absorbance sensors could be implemented along with conductivity sensors to measure salt concentration, refractive index sensors to track the PEG-citrate interface, and scales to track mixer and reservoir volumes to enable automated, continuous ATPS. Our vision is to integrate continuous ATPS into a fully continuous end-to-end production for viral vectors.

Plasma Proteomic Biomarkers Of Physical Frailty In Heart Failure: A Propensity Score Matched Discovery-Based Pilot Study, Quin Denfeld, Noelle Pavlovic, Christopher Lee, Jon Jacobs, Mary Roberts Davis, Samantha Powell, Marina Gritsenko, Susan Joseph, Beth Habecker

Division of Cardiology Faculty Papers

BACKGROUND: Physical frailty is highly prevalent in heart failure (HF), but we lack an understanding of the underlying pathophysiology. Proteomic evaluation of plasma samples may elucidate potential mechanisms and biomarkers of physical frailty in HF.

OBJECTIVES: We aimed to identify plasma proteomic biomarkers that are differentially expressed between physically frail and non-physically frail adults with HF.

METHODS: This was a secondary analysis of a subset of data and plasma samples from a study of frailty among patients with New York Heart Association (NYHA) Functional Classification I-IV HF. Physical frailty was measured using the Frailty Phenotype Criteria. Propensity score matching was …

Evolution Of The Tumor Immune Landscape During Treatment With Tebentafusp, A T Cell Receptor-Cd3 Bispecific, Joseph Sacco, Peter Kirk, Emma Leach, Alexander Shoushtari, Richard Carvajal, Camille Britton-Rivet, Sophie Khakoo, Laura Collins, Luis De La Cruz-Merino, Zeynep Eroglu, Alexandra Ikeguchi, Paul Nathan, Omid Hamid, Marcus Butler, Sarah Stanhope, Koustubh Ranade, Takami Sato

Department of Medical Oncology Faculty Papers

Metastatic uveal melanoma is an aggressive disease with poor outcome, which is refractory to immune checkpoint inhibitors. A T cell receptor (TCR)-based CD3 bispecific, tebentafusp, delivers clinical benefit in patients with metastatic uveal melanoma. Understanding the molecular basis for the anti-tumor activity of tebentafusp in an indication where checkpoint inhibitors are ineffective could aid in identification of other solid tumor indications where CD3 bispecifics may serve an unmet need. By analyzing tumor biopsies taken prior to treatment, early on-treatment, and at progression (NCT02570308), using RNA sequencing (RNA-seq) and immunohistochemistry (IHC), we show that expression of interferon-related genes in the tumor …

Longitudinal Assessment Of Moral Distress And Burnout During Pediatric Residency In A Canadian Site: Low Prevalence But Notable Risk Of Attrition, Kenneth S. Lee, Dianna C. Louie, Elaine O. Cheung, Peter Dodek, Dylan King, Kimee Chong

Journal of Wellness

Introduction: Although more than half of pediatric residents report burnout, the incidence of moral distress, the course of moral distress and burnout during residency, and associations between this course and personal characteristics of residents are unknown. The purpose of this work was to examine the incidence, temporal course, and associations of moral distress and burnout in pediatric residents.

Methods: In the pediatric training program of British Columbia Children’s Hospital, all residents were invited to complete the Moral Distress Scale-Revised thrice yearly, and the Maslach Burnout Inventory annually, between July 2016 and October 2018. In addition, residents reported a measure of …

Cover And Content

Turkish Journal of Physics

No abstract provided.

Modular Molecular Design Of Polymerized Pro-Estrogen Materials Enables Controlled Astrocyte Response, Devan L. Puhl, Alexis Ziemba, Samuel A.T. Ellman, Alex Hsu, Jayant Saksena, Penelope Phillips Falcone, Bailey Balouch, Deniz Rende, Tanner Fink, R. Helen Zha, Ryan J. Gilbert, Edmund F. Palermo

Chemical and Biochemical Engineering Faculty Research & Creative Works

The hormone 17β-estradiol (estrogen or "E2") has demonstrated robust neuroprotective properties in countering oxidative stress-induced neurotoxicity, as well as strong neurotrophic properties to promote axonal growth, following injury to the central nervous system (CNS). However, oral or injected E2 is a suboptimal drug, as systemic administration fails to achieve a therapeutic dose at the injury site, in addition to being contraindicated in most male patients. Polymerized pro-drug biomaterials can mitigate these issues by locally releasing small quantities of drug over vastly extended timescales. We sought to study the effect of the biomaterial properties of poly(pro-E2) on astrocyte-surface interactions because astrocytes …

Introduction To Prompt Engineering, Mary Rubin, Rachel Vacek

Faculty Scholarship and Creative Works

This presentation explores the fundamentals of effective prompt engineering, which involves well-crafted instructions for AI models to generate meaningful responses. Effective prompts can be written using frameworks like CLEAR and TRACI. The CLEAR Framework focuses on conciseness, logical structure, explicitness, adaptability, and reflection, while TRACI emphasizes task, role, audience, creation, and intent.

Additionally, the presentation addresses ethical considerations and best practices in prompt engineering, including academic integrity, attribution and transparency, and the importance of evaluation and assessment. By mastering these techniques, users can optimize their interactions with AI models, ensuring accuracy, relevancy, and minimizing bias.

Development Of Isoscapes For Hong Kong Freshwater Streams As A Basis For Ecological Studies, Hon Tim Yip

Lingnan Theses (MPhil & PhD)

Applications of isoscapes in terrestrial and marine ecosystems have grown notably as a tool for studying animal movement. However, isoscapes are rarely used in freshwater ecosystem because current iterations of isoscapes commonly model baseline distributions of bulk stable isotope analysis (SIA) data, which may be inadequate for providing the necessary resolution for fine spatial scale stream environments. This issue could potentially be addressed using compound specific stable isotope analysis, a new method that measures the isotopic composition of individual compounds to provide more comprehensive information than bulk SIA. My study focuses on δ¹³C of essential amino acids (EAA-δ …

Nanostructured Transition Metal Oxides For Electrochemical Co2 And Methane Conversion, Olumide O. Oladoyin

Chemical and Biological Engineering ETDs

Rising atmospheric CO₂ and CH₄ drive climate change, prompting research into their electrochemical conversion to valuable products. This study investigates electrodeposited nanostructured transition metal oxides (TMOs), unary (CuO, Co₃O₄) and dual (Cu-Co oxide) as catalysts for CO₂ reduction and CH₄ oxidation under ambient conditions. Fabricated on various substrates (Cu foil, SS316, carbon paper) and characterized by SEM, their electrochemical performance was evaluated via cyclic voltammetry.

Cu-Co oxide showed superior CO₂ reduction, leveraging the strengths of individual oxides. Co₃O₄ exhibited higher current densities for CH₄ oxidation, with SS316 proving the best substrate. Catalyst composition, morphology, and substrate significantly influenced efficiency. While …

Eyes On The Road: Disentagling Cyclist Mental Workload At Intersections, James Joseph Rawson

Civil Engineering ETDs

In North America, cyclists often share infrastructure with motor vehicles and encounter frequent conflicts with them at intersections. While past research assumes cyclists' experiences mirror those of drivers, most studies focus on roadway segments rather than intersections. This study addresses that gap by, for the first time we are aware of, examining cyclist perceptions at intersections using head and gaze movement data. Leveraging naturalistic data conducted in Albuquerque New Mexico, and statistical techniques, including t-test and repeated measures ANOVA, our findings suggest that – similar to drivers - cyclists do experience greater mental workload when performing turning movements than when …

Life After Death: Investigating The Resistance And Recovery Of Fungal Communities To Foundation Tree Mortality, Jessie F. Marlenee

Biology ETDs

Tree mortality can have cascading effects on the composition and resilience of interacting fungal communities. Yet, little is known about the impact tree mortality, distinct from abiotic drivers (i.e., drought), has on these communities. This dissertation focuses on the resilience of fungal communities to experimental tree mortality in a piñon-juniper woodland. In chapter one, I found that piñon mortality reduced piñon fine root biomass and piñon mycorrhizal fungal diversity, whereas juniper mycorrhizal fungi were unaffected by juniper mortality. In chapter two, I revealed that piñon mortality altered the composition and spatial structure of mycorrhizal and saprotrophic fungi in the soil, …

Horizonte Fronterizo: The Vitality Of Community And Contemporary San Diego-Tijuana Border Art, Ruben L. Loza

Chicana and Chicano Studies ETDs

This research dedicates attention to different examples of music and visual art that encompass contemporary San Diego-Tijuana border-integrated art. By employing a participant-observer approach with the music component and conducting plática-based interviews with all involved artists, this work underlines the vitality of the artworks’ manipulation of the U.S.-Mexico border wall and community as a driving force in the elaboration and growing influence of these projects and pieces. By analyzing how these works act as vehicles for response, light is also cast on greater matters that lie beyond the border zone: propagation of fear, anti-immigrant sentiment, and misinformed anxieties.

Uncovering Language Bias Towards Written Language Use Among Bilinguals And Individuals With Disabilities, Mu'nis Maen Nazzal

Linguistics ETDs

Language is a fundamental tool of social control. Linguistic bias plays a crucial role in social hierarchies and opportunities. While research has extensively documented linguistic bias in spoken language, less attention has been given to bias in written language. This study investigates students' evaluations of three instructors’ writings: a bilingual, an instructor with a disability, and a monolingual. The study employs a matched-guise technique to explore potential biases in students' perceptions of preference, leadership skills, expertise, and professionalism.

The Friedman Test revealed that while participants showed a preference for the instructor with a disability over the bilingual instructor and the …

Exploring Non-Traditional Yeast For Flavor Innovation In Non-Alcoholic Beer, Andrew Maust, Rahul Sen, Scott Lafontaine

Food Science Faculty Publications and Presentations

The demand for nonalcoholic beer (NAB) is growing, with nontraditional yeast strains emerging as valuable tools for brewers to craft distinct NABs. However, independent information about the performance of these commercially available yeasts remains limited. In this study, 11 nontraditional yeast strains were evaluated at two wort nutrient levels to assess their impact on beer chemistry, sensory attributes, and volatile profiles. Basic fermentation metrics were monitored, followed by descriptive sensory analysis and GC-MS/MS quantification of volatile compounds. Results revealed significant differentiation among yeast strains with unique aroma and flavor profiles driven by variations in ester production, fusel alcohol synthesis, and …

Staff Update On Type 2 Diabetes Education, Toochukwu Endaline Mba

Walden Dissertations and Doctoral Studies

The current rise in Type 2 diabetes among middle-aged individuals poses significant risks of health complications such as kidney damage, heart disease, stroke, nerve damage, vision loss, and skin problems. Research has shown that proper education on the causes and risk factors of Type 2 diabetes would increase people’s knowledge about the medical problem, helping promote positive health outcomes. This project was a staff education program using didactic and interactive case studies.

Mental Health Wellness For Female Law Enforcement Executives And Their Perception Of Proactive Mindsets, Cindy Elizabeth Baughman

Walden Dissertations and Doctoral Studies

This qualitative study aimed to examine how female law enforcement executives perceive the use of mental health wellness in their professions. The phenomenological design provided an increased understanding of the lived experiences of those interviewed, specifically regarding their use of mental health wellness. The snowball sampling technique was utilized to recruit seven female law enforcement executives at the Sheriff, Under Sheriff, Chief, or Deputy Chief rank. One-on-one interviews were completed, data collected from the interviews was transcribed using NVivo software, and collectively, common themes amongst the participants’ interviews were identified. The gap in the research and the associated qualitative interview …

Sustainable Cash Flow Management Strategies For Small To Medium-Sized Service Businesses, Melody Gray

Walden Dissertations and Doctoral Studies

Nearly 50% of small to medium-sized enterprises (SMEs) fail within five years, resulting in financial losses for business owners and reduced employment opportunities. Entrepreneurs care about this issue because poor cash flow management is a major contributor to business failure, threatening economic growth and job stability. Grounded in working capital management, the purpose of this qualitative, multiple case study is to explore successful cash flow management strategies for service industry SME owners to sustain free cash flow beyond 5 years. The study included four SME owner participants in the Dallas/Fort Worth metroplex who successfully started and sustained the business beyond …

Clinical Practice Guideline Workflow For Medication Prescription, Patience Morikang

Walden Dissertations and Doctoral Studies

The type of project was a clinical practice guideline (CPG) workflow for medication prescriptions. The practice problem was the lack of an evidence-based approach regarding medication prescriptions, resulting in increased errors. It is essential to address this problem to promote safe prescribing, increase team knowledge, and encourage patient safety in the organization and within nursing practice. The practice focused question was the following: Will a clinical practice guideline for medication prescription workflow be approved by experts for use in an outpatient mental health clinic to promote the reduction of errors? The project aimed to seek expert approval of a CPG …