Digital Commons Network^™

Evidence-Based Alternative Pain Management Techniques For Chronic Pain, Alise Williams Condie, Ashley Yaugher, Kira Swensen, Maren Wright Voss

All Current Publications

Chronic pain and opioid use have become topics of importance as opioid overdose deaths have risen to epidemic proportions throughout the nation. Chronic pain lasts for long periods of time and can be caused by a past injury or have no known cause. Opioids have been utilized to treat pain in the past, but it has been discovered that opioids are better used to treat acute pain and not chronic pain. Opioids can have negative consequences including changes to the brain, depression, increased pain, constipation, sedation, and even death. This fact sheet reviews and explains some of the most successful …

Swi/Snf Complex-Mediated Znf410 Cooperative Binding Maintains Chromatin Accessibility And Enhancer Activity, Siyuan Xu, Chuxuan Peng, Ren Ren, Haowen Lu, Han Zhao, Yijie Shen, Haoyue Zhang, Xiaodong Cheng, Gerd A Blobel, Xianjiang Lan

Faculty, Staff and Student Publications

The clustering of multiple transcription factor binding sites (TFBSs) for the same TF has proved to be a pervasive feature of cis-regulatory elements in the eukaryotic genome. However, the contribution of binding sites within the homotypic clusters of TFBSs (HCTs) to TF binding and target gene expression remains to be understood. Here, we characterize the CHD4 enhancers that harbor unique functional ZNF410 HCTs genome wide. We uncover that ZNF410 controls chromatin accessibility and activity of the CHD4 enhancer regions. We demonstrate that ZNF410 binds to the HCTs in a collaborative fashion, further conferring transcriptional activation. In particular, three ZNF410 motifs …

Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon

Faculty, Staff and Student Publications

Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have endeavored to translate these molecular tools into clinical imaging agents. Despite these efforts, there are no clinically approved imaging methodologies with which to image cell death consistently and quantitatively. One reason may reside in the intrinsic mismatch between the sampling frequency of translational molecular imaging and the biochemical kinetics that define cell death. Beyond cell death imaging, many active research programs are now attempting to create translational diagnostic …

Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis In 24 539 Individuals, Yezhi Pan, Chuan Bi, Zhenyao Ye, Hwiyoung Lee, Jiaao Yu, Luba Yammine, Tianzhou Ma, Peter Kochunov, L Elliot Hong, Shuo Chen

Faculty, Staff and Student Publications

Introduction: Nicotine addiction, a multifaceted neuropsychiatric disorder, profoundly impacts brain functions through interactions with neural pathways. Despite its significance, the impact of tobacco smoking on the whole-brain functional connectome remains largely unexplored.

Aims and methods: We conducted a whole-brain analysis on 24 539 adults aged 40 and above from the United Kingdom Biobank cohort. Subjects were categorized into individuals who use nicotine and those who do not use nicotine based on current and chronic tobacco smoking information. Functional connectivity was assessed using resting-state functional magnetic resonance imaging. We employed a network analysis method to assess the systematic effects of tobacco …

Ensemble Learning With Explainable Ai For Improved Heart Disease Prediction Based On Multiple Datasets

Faculty, Staff and Student Publications

Heart disease is one of the leading causes of death worldwide. Predicting and detecting heart disease early is crucial, as it allows medical professionals to take appropriate and necessary actions at earlier stages. Healthcare professionals can diagnose cardiac conditions more accurately by applying machine learning technology. This study aimed to enhance heart disease prediction using stacking and voting ensemble methods. Fifteen base models were trained on two different heart disease datasets. After evaluating various combinations, six base models were pipelined to develop ensemble models employing a meta-model (stacking) and a majority vote (voting). The performance of the stacking and voting …

Investigating Behavioural Responses Of Tiger Sharks (Galeocerdo Cuvier) To Novel Stimuli By Means Of Benthic Baited Remote Underwater Video Systems, India Brawermann, Alexander Horne, Grant Smith, Alexander Wilson

School of Biological and Marine Sciences

Inspection behaviour in sharks, involving their approach and assessment of potential prey or threats, is vital for their predatory efficiency and defensive strategies, heavily influencing ecological dynamics and predator-prey interactions. This study investigates object inspection behaviour in tiger sharks (Galeocerdo Cuvier) using Baited Remote Underwater Video systems (BRUVs) deployed within the iSimangaliso Wetland Park (IWP) Marine Protected Area, in South Africa. Data collection and analysis focused on quantifying the frequency, duration, and characteristics of tiger shark interactions with BRUVs, and on assessing behavioural trends across demographic groups to facilitate the development of a behavioural ethogram. Key findings revealed adult females …

Effect Of Precursors On Trimetallic Ruthenium-Based Catalysts Supported On Γ‑Al2O3 Pellets For Low-Temperature Ammonia Decomposition, Christopher J. Koch, Jennifer Naglic, Logan Kearney, Daniel Clairmonte, Binod Rai, Jochen A. Lauterbach, Lucas M. Angelette, Tyler Guin

Faculty Publications

Ammonia is a promising candidate as a liquid hydrogen energy storage medium, but it requires catalytic decomposition (ammonia cracking) to regenerate hydrogen. Recently developed trimetallic ruthenium−potassium-promoter (RuKM) ammonia decomposition catalysts have exceptionally low ammonia decomposition temperatures, able to perform the decomposition as low as 250 °C, which is significantly lower than other known catalysts that require temperatures above 500 °C. However, the effects of the RuKM precursor on the catalytic activity have not been investigated. We report the observed differences of 3% ruthenium/12% potassium/1% yttrium (RuKY) catalysts on γ-alumina synthesized from chloride-, nitrate-, and acetate-based precursors. Catalysts synthesized from chloride-based …

U.S. Copyright Law Is Fashionably Late To Regulating Ip Compliance In The Fashion Industry, Susannah Theus

Louisiana Law Review

No abstract provided.

An Intercomparison Of Wall Fluxes In A Turbulent Thermal Convection Chamber: Direct Numerical Simulations And Wall-Modeled Large-Eddy Simulations Enhanced By Machine Learning, Aaron Wang, Silvio Schmalfuß, Kamal Kant Chandrakar, Hadi Zanganeh Kia, Fan Yang, Mikhail Ovchinnikov, Raymond A. Shaw, Yunsoo Choi

Michigan Tech Publications

Thermal convection in a closed chamber is driven by a warm bottom, a cold top, and side walls at various temperatures. Although wall fluxes are the source of convection energy, accurately modeling these fluxes (i.e., the wall model) is challenging. In large-eddy simulations (LESs), many wall models are traditionally derived from the canonical boundary layer, which may be unsuitable for thermal convection bounded by both horizontal and vertical walls. This study conducts a model intercomparison of dry convection in a cubic-meter chamber using three direct numerical simulations (DNSs) and four LESs with different wall models. The LESs employ traditional wall …

Outdoor Learning On The Edge Of Europe: A Systematic Review Of Practice From Ireland, Tomás Aylward, Maura Colter, Tom Farrelly

Publications

Outdoor Learning (OL) programmes are a small but impactful part of the Irish educational landscape. This paper presents an overview of the sector through a systematic review of the literature published between 2012 and2023. The research had three aims: to 1) map the strands of practice where OL-related research is happening; 2) synthesize the reported outcomes and 3) indicate gaps in the research. Of the 157 papers screened, 13 met the criteria for inclusion. A hybrid method of review based on reflexive and meta-aggregative synthesis was utilized. Eleven lines-of-action findings were identified across four areas-of-action. These areas were: the role …

The Use Of Person-Centered Language In Scientific Research Articles Focused On Psychosis, Zach Monahan, Tanner Stone, Vinay Swami, Kelly Dunn, Micah Hartwell

Journal of Patient-Centered Research and Reviews

Purpose: Societal stigma of psychosis leads to delayed treatment for individuals experiencing early symptoms, for fear of being labeled “crazy” or “psychotic.” Delayed treatment can worsen the prognosis of individuals with psychosis. Proper adherence to person-centered language (PCL) guidelines can curb the widely held stigmatized preconceptions about psychotic conditions.

Methods: Our meta-epidemiological analysis began with a systematic search of literature in PubMed discussing psychosis from 2020-2022. From the 14,522 results, we randomly selected 500 articles in journals with at least 20 articles on psychosis (n = 9,775), of which 241 articles met the inclusion criteria. These papers were screened for …

Evaluation Of The Adjunctive Effect Of Photodynamic Therapy For The Treatment Of Residual Periodontal Pockets: A Systematic Review, Shankargouda Patil, Charles Miller, Ryan Moffat, Kade Janes, Brooklyn Janes, Peter M. Loomer, Frank W. Licari

Journal of Patient-Centered Research and Reviews

Purpose: Adjunctive use of photodynamic therapy in combination with scaling and root planing for periodontal maintenance offers an alternative to antibiotic therapy, potentially mitigating the risk of antibiotic resistance and its genotoxic or mutagenic effects. This systematic review analyzed studies, as of January 2023, that included the effects of a single application of photodynamic therapy in residual periodontal pockets with the probing depth and clinical attachment level as the primary and secondary outcomes, respectively.

Methods: PubMed, Scopus, and Web of Science databases, as well as the US National Institutes of Health and WHO Clinical Trials Registry, were searched for eligible …

Bridging The Gap Between Knowledge And Practices Pertaining To Naloxone Use: A Single-Institution Experience In North Carolina, Michael S. Argenyi, Gisele Bailey, Christopher J. Mclouth, Erin Barnes, Candice J. Mcneil

Journal of Patient-Centered Research and Reviews

Naloxone is a life-saving medication for opioid overdose, which claims many lives annually. This study investigated provider attitudes about, beliefs about, and barriers to naloxone use to inform an increase in provider prescription of naloxone. The survey took place at a large Southern tertiary health center. An adapted REDCap survey utilizing validated questions was distributed via institutional e-mail listservs. The results (N = 181) were analyzed using descriptive and chi-square statistics. While 90.9% of the providers had heard of the strategy of prescribing naloxone to prevent overdose, only 72.1% of providers would have considered prescribing naloxone. Providers reported implementing treatment …

Advancing A Patient- And Carer-Centered Approach For The Clinical Development Of New Therapeutics For Aneurysmal Subarachnoid Hemorrhage: Insights From A Qualitative Study, Sonya Abraham, Silvia Amaro, Ellyn Getz, Sylvia Herget, Gregory J. Kato

Journal of Patient-Centered Research and Reviews

Aneurysmal subarachnoid hemorrhage (aSAH) is characterized by a high rate of fatality and high risk of secondary brain injury. More treatment options are needed to improve outcomes. There are very few reports in the medical literature involving patient experience of aSAH, which is known for its unexpected onset and profound medical impact. Improved understanding of this patient experience would help make future clinical research more patient centered. To this end, we convened an advisory board consisting of aSAH patients and care partners in the United States. Participants emphasized the critical role that care partners play during hospitalization and in accessing …

Floating And Submerged Plants Of Utah: Pocket Field Guide, Kate Sinnott, Karin M. Kettenring

All Current Publications

This is a field guide to identifying floating and submerged plants of Utah. We include a page for each species and also a dichotomous key at the end for the pondweeds. Submerged and floating plant species play critical roles in aquatic ecosystems. They provide habitat to aquatic organisms, improve water clarity by trapping sediment, and absorb excess nutrients from the water column, among other vital services. However, they have been threatened and degraded by pollution, land conversion, and introductions of harmful species. Identifying native and non-native plants is an important component of tackling this degradation and promoting the conservation and …

Impacts Of Climate Change On Cannibalism And Disease Transmission In The Fall Armyworm, Kale Rougeau

LSU Master's Theses

Climate change may alter host-pathogen dynamics in terrestrial ecosystems due to rising global temperatures and carbon dioxide levels. Here, we examined cannibalism and disease transmission using the fall armyworm (Spodoptera frugiperda), an invasive agricultural pest, and its species-specific lethal baculovirus, Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), under various potential challenges of climate change. We used three temperature treatments (cooler, optimal, warmer) based on the fall armyworm’s thermal performance curve to simulate a changing climate and four artificial diets with various protein-to-carbohydrate ratios (low, equal, high, standard) to manipulate resource quality from altered carbon dioxide levels. We found that higher …

Global Ocean Bottom Temperature Observation Design: Observing System Simulation Experiments For Strategic Deployment Of Smart Subsea Cables, Karen E. Renninger-Rojas

LSU Master's Theses

Deep-ocean observations below 2000 meters remain limited, restricting our ability to model global ocean processes critical to climate prediction. This thesis evaluates the potential of SMART (Science Monitoring and Reliable Telecommunications) subsea cables to address these observational gaps by conducting Observing System Simulation Experiments (OSSEs) and adjoint sensitivity analyses using the MITgcm ocean model and ECCO outputs.

Vertical decorrelation analysis showed that temperature and salinity in key regions decouple from the upper ocean beyond 2000 m. Over 60% of the proposed SMART cable sites exhibited decorrelation depths exceeding Argo’s maximum sampling depth, highlighting their strategic value for deployment.

A comparison …

Advancing Aerial Survey Techniques For Non-Breeding Waterfowl Populations: A Comprehensive Review And Application In Northeastern Louisiana, Victoria L. Drake

LSU Master's Theses

Aerial surveys play a crucial role in monitoring North America's waterfowl populations and habitat conditions, and consistency across geographies and years allows biologists to track trends through time. The goal of this project was to redesign the northeastern portion of the Louisiana wintering waterfowl survey to align with statistically robust transect surveys conducted in neighboring states within the Mississippi Alluvial Valley. To identify the optimal sampling method, we evaluated three transect weighting schemes: stratified random (unweighted), stratified by watershed, and stratified by expert opinion. Approximately 10% of the total sampling area was randomly selected for each survey period, adhering to …

Thompson’S Rifle Battalion: The Original Unit Of The Army Of The United Colonies (Now The United States Regular Army), John A. Bonin

Books, Monographs & Collaborative Studies

©2025 John A. Bonin

Although 1775 is indisputably the birth year of the US Army, two events occurred on June 14 of that year to which the Army can credit its birthday. One is the adoption by the Continental Congress of the collective militia forces from several colonies outside Boston to form a Continental Army, of which Congress appointed George Washington the commander in chief on June 15, 1775. In addition, the US Regular Army officially dates its beginning to June 14, 1775, when the Second Continental Congress directed 10 companies of expert riflemen to be raised immediately in Pennsylvania, …

Evolutionary Biology In Latin America: Perspectives On Science, Religion And Society, Enrique Lessa

LAII Events

Tuesday, April 22,2025

(Castetter Hall 100 (219 Yale BIvd NE)

Join the LAll, the UNM Department of Biology, and the Guadalupe Institute for a discussion about evolutionary biology in Latin America.

Evolutionary biology has been at the center of conflicts between science and religion for the last two centuries. In Latin America, the relationship between science in general-and evolution in particular-and religion varies dramatically as a function of the history and profiles of the countries in the region. Post-truth radicalism globally is pushing anti-science sentiment to new extremes, and urgent, defensive and offensive action is needed. There is also a …

Unveiling The Potential Of Urolithin A In Cancer Therapy: Mechanistic Insights To Future Perspectives Of Nanomedicine, Vinita Karumuru, Anupam Dhasmana, Narsimha Mamidi, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Cancer remains a leading global health challenge, with high mortality rates persisting despite significant advancements in therapeutic interventions. Major obstacles, including systemic toxicity, therapy resistance, metastasis, and relapses, emphasize the urgent need for safer, more effective, and readily accessible treatment strategies. Among emerging alternatives, natural bioactive compounds have gained considerable attention because of their diverse therapeutic potential and lower toxicity profiles. Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent. UA has multiple mechanisms of action, including the regulation of autophagy, enhancement of mitochondrial function, and inhibition of tumor …

First Endovascular Flow Diversion Treatment For A Supergiant Brain Aneurysm (>110 Mm) In Ethiopia, Wondwossen G. Tekle, Eskedar Kebede Belayneh, Kaleab Tesfaye Eticha, Tariku Assefa Soboka, Michael Yirgalem Teka, Hilina Agonafir Mengistu, Yonatan Wudeneh Mekonnen, Fikru Tsehayneh Kelemu, Bereketeab Ethiopia Bogale, Eden Enyew Zeleke

School of Medicine Publications

In late 2022, a 65‐year‐old woman presented to us with a 3‐day history of ischemic stroke resulting in left facial droop and left‐sided weakness. She had a known giant right internal carotid artery (ICA) aneurysm since 2015 that kept on growing and causing her a myriad of neurologic signs and symptoms including recurrent severe headaches, debilitating tinnitus, right‐sided vision loss (2020), proptosis, ophthalmoplegia, ptosis, and hearing loss. She had allodynia in the right trigeminal nerve distribution, complete right facial palsy, new left lower facial palsy and left hemiparesis (3/5 strength). Unfortunately, local treatment options were unavailable at that time, and …

Dna Methylation Signature Of A Lifestyle-Based Resilience Index For Cognitive Health, Lissette Gomez, Michael A Schmidt, Eden R Martin, Brian W Kunkle, X Steven Chen, Deirdre M O'Shea, James E Galvin, Lily Wang

Faculty, Staff and Students Publications

Cognitive resilience (CR) contributes to the variability in risk for developing and progressing in Alzheimer's disease (AD) among individuals. Beyond genetics, recent studies highlight the critical role of lifestyle factors in enhancing CR and delaying cognitive decline. DNA methylation (DNAm), an epigenetic mechanism influenced by both genetic and environmental factors, including CR-related lifestyle factors, offers a promising pathway for understanding the biology of CR. We studied DNAm changes associated with the Resilience Index (RI), a composite measure of lifestyle factors, using blood samples from the Healthy Brain Initiative (HBI) cohort. After corrections for multiple comparisons, our analysis identified 19 CpGs …

Empowering Society Through Digitalization Of Msmes During The Recession, Diah Ajeng Purwani, Etika Prasetyaningrum, Anindya Septiana Arfiani

JURNAL KOMUNIKASI INDONESIA

One of the sectors and regions affected by the recession in Indonesia’s economic condition is Micro, Small, and Medium Enterprises (MSMEs) in Yogyakarta. Some of the problems that arise include a decrease in MSME turnover, which leads to a reduction in the number of employees. MSMEs need to maintain their businesses if they need to keep up with increasingly rapid technological developments in the online realm in their marketing strategies. The method used in this research is community-based research (CBR) based on cases in the field, which takes the MSME community as the research objective studied through digitalization on social …

Decolonial Underground Pedagogy: Unschooling And Subcultural Learning For Peace And Human Rights, Jazzmin C. Gota

International Journal of Human Rights Education

As an Asian American unschooler growing up in California in the 1990s, I have heard (and had scolded at me by people outside my family) theories and ideas of what education is as well as what it can and cannot be. I vividly recall being told that homeschooling, let alone unschooling (i.e., learning outside of a curriculum or hierarchical structure, see page 57) would stunt my intellectual and social growth. How could I learn outside of a formal classroom? Fast forward 30 years and now I am a doctoral student in International and Multicultural Education, ecstatic to see a book …

Rethinking Human Rights: Critical Insights From Palestinian Youth, Mai Awad

International Journal of Human Rights Education

The Universal Declaration of Human Rights (UDHR) was adopted in 1948, articulating a bold vision of a future in which every human being has the essential rights of dignity, freedom, and justice. But so much of that promise may now be at risk, especially with regard to how the UDHR addresses systemic inequities rooted in colonial legacies. This contradiction is especially evident in the lived experiences of marginalized communities in the Global South—where structural inequalities are entrenched in the everyday fabric of life. In the Occupied Palestinian Territories (OPT), for example, principles of human rights appear light years from the …

Queering The Global Filipina Body: Contested Nationalisms In The Filipina/O Diaspora, Edian Valenzuela

International Journal of Human Rights Education

Queering the Global Filipina Body: Contested Nationalisms in the Filipina/o Diaspora, written by Gina K. Velasco, engages with the intersections and relationships of gender, sexuality, and nationalism as it is understood through the nuanced and complex variations of Filipina/o diasporic identities and communities. This book delves into how Filipina/o diasporic identities are constructed, contested, and recreated through the different expressions of gender and sexuality through the discussion of the concept of the Global Filipina Body.

Youth Fiction And Trans Representation, D. Perez-Sornia, Emmanuel Te

International Journal of Human Rights Education

Tom Sandercock begins Youth Fiction and Trans Representation asserting that this is the first book to catalog and trace transgender and gender variant representation across various forms of media (Sandercock, p. i). Sandercock presents a compelling collection of transgender representation case studies, with an intended audience of transgender studies scholars, LGBTQ+ and allied educators seeking to add meaningful gender-explorative literature to their curriculum, and transgender people interested in a gender retrospective view of their childhood or adolescent media. Examining not only mere representation of young transgender and gender variant people, Sandercock explores the intersections of gender and various vertices of …

The Skin And Its Girl: A Novel, Michelle Simotas

International Journal of Human Rights Education

If you’re not reading queer Palestinian stories, you should start. Queer Palestinians have been fighting for their right to live and tell their stories, as queer stories have been criminalized and labeled as a threat to “morality and public decency” (Kakissis, 2017, para 10). In November 2023, “Queering the Map” became an online story wall for queer Palestinians living in Gaza to claim space and be remembered (O’Neal, 2023). Reading these and other queer Palestinians’ stories is an act of resistance. It is through these stories that readers can humanize and connect to the queer Palestinian experience, ensuring it cannot …

Insufficient Memory, Sean Fader

International Journal of Human Rights Education

Artist Statement

Insufficient Memory examines a window of time from 1999 to 2000, when the Hate Crimes Prevention Act was first being debated in Congress (and not passed). In 2018 I discovered an old Sony Digital Mavica which was the first commercially successful digital camera sold in 1999 to 2000. This camera was considered groundbreaking technology because it shot ⅓-of-a-megapixel images to a 3.5-inch floppy. I began thinking about what was overlooked, invisible, or erased in the same moment as that digital camera began to revolutionize imaging and visibility.