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Safety And Efficacy Of Single-Dose Primaquine To Interrupt Plasmodium Falciparum Malaria Transmission In Children Compared With Adults: A Systematic Review And Individual Patient Data Meta-Analysis, Wwarn Paediatric Primaquine For P Falciparum Transmission Blocking Study Group, Daniel Yilma, Kasia Stepniewska, Teun Bousema, Chris Drakeley, Prashanti Eachempati, Philippe J. Guerin, Andreas Mårtensson, Richard Mwaiswelo, Walter R. Taylor, Karen I. Barnes

Peninsula Dental School

Background: Adding a single dose of primaquine to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria can reduce the transmission of Plasmodium falciparum and could limit the spread of artemisinin partial resistance, including in Africa, where the disease burden is greatest. We aimed to compare the safety and efficacy of single-dose primaquine plus ACT between young children (aged <5 years) and older children (aged 5 years to <15 years) and adults (aged ≥15 years), and between low and moderate-to-high transmission areas. Methods: For this systematic review and individual patient data meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, WHO Global Index Medicus, OpenGrey.eu, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform, from database inception to April 3, 2024, with no language restrictions. We included prospective studies on efficacy against falciparum malaria that enrolled at least one child younger than 15 years and involved a study group given a single dose of primaquine (≤0·75 mg/kg) plus ACT. Studies involving mass drug administration, healthy volunteers, or patients with severe malaria or mixed (with non-falciparum) infections were excluded. For inclusion in the efficacy analysis, data on transmission potential (as determined by gametocytaemia, infectivity, or both) at enrolment and follow-up (day 3, day 7, or day 14) were required; the safety analysis required data on haemoglobin concentrations or haematocrit values at enrolment and at one or more follow-up visits by day 7, any data on adverse events, or both. After independent screening of the search results by two reviewers, the investigators of eligible studies were invited to contribute individual patient data. We quantified day 7 gametocyte carriage, probability of infecting a mosquito, decreases (>25%) in haemoglobin concentration associated with anaemia, and adverse events until day 28 using regression analyses, with random study-site intercepts to account for clustered data. These analyses were registered with PROSPERO, CRD42021279363 (safety) and CRD42021279369 (efficacy). Findings: Of 5697 records …

Is Aid Good For The Poor In Sub-Saharan Africa?, Elisha Mavodyo

Business Review

We contribute to the aid-poverty literature in Sub-Saharan Africa in two fundamental respects. First, we sidestep the controversial aid-growth-poverty relationship by analysing the direct impacts of aid on poverty in Sub-Saharan Africa. Second, in line with previous studies, we first analysed the impact of aid on poverty headcount, poverty gap, and poverty gap squared. We complemented this analysis with an analysis of the direct impact of aid on the incomes of the poor, followed by an analysis of aid on inequality. Such an approach allowed us to draw nuanced conclusions about how effective foreign aid is in alleviating not just …

Determinants For Green Procurement Practices In Public Procurement Management In Tanzania, Yohana Arsen Rutaba

Business Review

This study was carried out conducted to ascertain the determinants for green procurement practices in public procurement management in Tanzania. The research study employed mixed-methods approach and used descriptive analysis. Multiple linear regression analysis was employed to establish the relationship between the variables. The study used a sample size of 200 participants obtained using Cochran formula of unknown population. The sample size composed of public procurement officers and practitioners from different government agencies and organization in Mainland Tanzania. From descriotive analysis it shows that the level of implementation of green procurement practices is still very low in public procurement. The …

Dual Implants For Geriatric Distal Femur Fractures Results In Greater Healthy Days At Home, Makoa Mau, Tyler Thorne, Cole Payne, Kaleb Roach, Reese Svetgoff, Patrick J Kellam, Graham J Dekeyser, Stephen J Warner, Lucas S Marchand, Justin Haller

Faculty, Staff and Student Publications

Objectives: To compare Healthy Days At Home (HDAH90) within 90 days of hospital discharge after single implant (SI) or dual implant (DI) fixation in geriatric distal femur fractures.

Methods: Design: Retrospective Review.

Setting: Three Level I Trauma Centers.

Patient selection criteria: Geriatric (age ≥ 60 years) distal femur fracture patients (OTA/AO 33 A, C) operatively treated with SI (lateral plate or retrograde intramedullary nail (IMN)) or DI (two plates or plate and IMN) between January 2018-January 2024 were included.

Outcome measures and comparisons: The primary outcome was HDAH90, which was calculated from date of surgery to 90 days follow-up and …

Improved Soil Parameters For Lateral Pile Analysis From Full-Scale Load Tests In Cohesionless Soil, Dallin Bruce Widmer

Theses and Dissertations

One common software program developed for analyzing single laterally loaded piles is called LPILE. Soil properties are required as input into LPILE. For sands, the soil properties required are effective soil unit weight, γ’; modulus of subgrade reaction, k; and the internal friction angle,ϕ’. There are two commonly used methods to obtain ϕ’ and subsequently k: the API method and Bolton method. Using the Bolton method to determine the soil strength properties gives more accurate load deflection values with respect to measured values from field tests. The Bolton method led to a 46% reduction in the predicted deflection error compared …

Exploring The Associations Between Young Adults' Autistic Traits And Parental Differential Treatment, Madelyn Winder Bennett

Theses and Dissertations

The current study sought to identify autistic traits that may elicit parental differential treatment (PDT). Understanding these links are important because numerous studies have shown PDT to have negative implications for healthy development. Participants (recruited via Amazon Mechanical Turk) completed a survey assessing their experiences of parental differential treatment and their own autistic traits using the Autism Quotient (AQ) measure (Baron-Cohen et al., 2001). Participants were young adults ages 18-29 (M age = 25.4; 57% Female, 43% Male; 73% White, n = 739) who resided in the U.S. and had at least one living sibling. Using regression analysis, we examined …

Influence Of The Duchesne Fault Zone On Oil Production In The Uinta Basin, Utah, Alan Matthew Ketring

Theses and Dissertations

The Duchesne Fault Zone (DFZ) is a series of east-west trending en echelon faults that developed synchronously above the neutral surface of the Duchesne Anticline during the Laramide Orogeny. The Duchesne Graben (DG) formed by decrease in displacement downward toward the neutral surface. Lake Canyon, a region that exposes the subsurface geology on the western portion of the DFZ, serves as an analog for fold formation within the saline facies of the lower Green River Formation, while Indian Canyon, an area created from the dip-slip faulting of the DG, provides clear exposures of the faulting within the sandstone-limestone facies of …

2025-04-23 Handbook “Does Not Apply” To Academic Program Cuts, Provost’S Office Says, Daniel Truog

The Spectator Online

No abstract provided.

Passive Integrated Transponders: An Effective Marking Technique For Individual Identification Of Anaxyrus Fowleri?, Emily Leprell

Honors College Theses

With the rise of fungal disease such as Chytridiomycosis, known as chytrid, causing massive population declines for many species of frogs and toads (order Anura), specific conservation strategies are needed now more than ever. In many cases, being able to mark and identify individuals is a necessary step in developing an effective conservation plan. Individual identification allows researchers to obtain accurate population estimates, which are needed to test the progress and validity of conservation management decisions. However, due to their unique life history, including cutaneous respiration and a dichotomous lifestyle, anurans are among the most difficult wildlife species to …

The Economic Factors Of Suicide, Hogan C. Fox

Honors College Theses

This study examines how macroeconomic indicators influence state‐level suicide rates in the United States and, critically, how those effects differ by gender. Drawing on annual data from all fifty states over 2010–2020, I merge age‐adjusted suicide rates from CDC WONDER with five key economic indicator: real hourly compensation, labor productivity, employment rate, median income, and logged state GD, from the Bureau of Labor Statistics, Census Bureau, and the Bureau of Economic Analysis. After comparing pooled OLS, random‐effects, first‐difference, and two‐way fixed‐effects specifications, I adopt a two-way, state‐and‐year fixed‐effects model for its superior fit and capacity to control for unobserved heterogeneity. …

Methods For Rotating Electrodes In High-Temperature Molten Salts, Ranon Fuller, Eloise Cluff, Edward Mercado, Carlos Mejia, Devin Rappleye

Faculty Publications

In this paper, we describe and validate a custom apparatus for performing high-speed (250-3,500 rpm) rotating electrode and dilatometer density experiments in molten salts. The reported details can aid in decreasing the difficulty and increasing the quality of such experiments. We discuss the design challenges and the solutions identified. We investigate methods for accurately measuring the solution resistance using electrochemical impedance spectroscopy (EIS), calculating the working electrode area using cyclic voltammetry (CV), and measuring the mass transfer-limited current of rotating electrodes using a series of chronoamperometry (CA) pulses. We further demonstrate the efficacy of our methods in producing accurate results.

Use Of Procalcitonin In Therapeutic Decisions In The Pediatric Intensive Care Unit, Pierre Tissières, Elisabeth Esteban Torné, Johannes Hübner, Adrienne Randolph, Corsino Rey Galán, Scott Weiss

Department of Medicine Faculty Papers

Procalcitonin (PCT) is frequently used by clinicians in children with suspected bacterial infections and sepsis. However interpretation in the critically ill child may be challenging due to the complexity of underlying conditions and its impact on PCT values. Herein, we propose a guidance for the use of procalcitonin in critically ill children, supported by a comprehensive analysis of the literature, to help the clinician for interpreting PCT in the various clinical conditions encountered in pediatric intensive care units. We describe the importance of the clinical context, timing of measurement and evidence on PCT values in diagnosing sepsis and to guide …

Inhibition Of Soluble Epoxide Hydrolase Confers Neuroprotection And Restores Microglial Homeostasis In A Tauopathy Mouse Model, Shuo Wang, Chuangye Qi, Chetan Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, Sung Hee Hwang, Bruce D Hammock, Hongjie Li, Li Gan, Hui Zheng

Center on Aging Staff Publications

Background: The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by soluble epoxide hydrolase (sEH). Inhibition of sEH has been shown to stabilize the EETs and reduce neuroinflammation in Aβ mouse models of Alzheimer's disease (AD). However, the role of the sEH-EET signaling pathway in other CNS cell types and neurodegenerative conditions are less understood.

Methods: Here we investigated the mechanisms and functional role of the sEH-EET axis in tauopathy by treating PS19 mice with a small molecule sEH inhibitor TPPU and by crossing the …

University Philharmonic Orchestra & Mixed Chamber Ensembles

Bailey School of Music Concert Programs

Nancy Conley, Conductor

Nh Republicans Close Ranks Around Trump Amid Tariff Fears 4/23/2025, Unh Survey Center

All UNH Survey Center Polls

Approval of President Trump's job performance among New Hampshire Republicans has hit a record high, along with the percentage of Republicans who feel the country is headed in the right direction. While Granite Staters overall continue to disapprove of Trump's use of tariffs and fear they will lead to substantially higher prices for goods, Republicans are warming up to tariffs, with most anticipating only a slight increase in prices and a net positive effect for the economy. A slight majority in New Hampshire feel the country is on the wrong track, with many citing the president or Republicans in power …

Vermonters Strongly Oppose Trump's Handling Of Economy, Tariffs, And Immigration 4/23/2025, Unh Survey Center

All UNH Survey Center Polls

Vermonters have negative assessments of Donald Trump's actions as president with two-thirds disapproving of his handling the economy, immigration, and his overall job performance. Republicans remain staunchly behind Trump. Vermonters are uneasy about tariffs and most expect them to harm the country's economy and result in much higher prices for goods. Residents are also pessimistic about the direction of the country.

From Collections To Community-Changing The Educational Landscape To Serve The People: Case Studies Of Adult Education In Urban Art Museums, Ruth Houston Lockard

Electronic Theses and Dissertations Archive

Drawing on constructivism, this multiple case study examined the museum’s role in society as a place for learning. The purpose of the study was to describe how these museums provide constructivist educational programming that connects museum collections to the communities where they are located and promotes social justice by creating a gathering place for people to discuss contemporary issues. The research question directing this study is “how do the National Gallery of Art and the National Civil Right Museum’s adult education programs connect with the communities where they are located and promote social justice?” This multiple case study analyzed learning …

From Global Trends To Patient-Level Data: Helping Adolescents With Sickle Cell Disease Become Adults, Kelly Pimenta

Electronic Theses and Dissertations Archive

Sickle cell disease (SCD) is an inherited hemoglobinopathy that remains a major contributor to global morbidity and mortality. While advances in neonatal screening, therapeutic interventions, and supportive care have significantly improved survival rates, individuals with SCD continue to experience challenges, particularly during pediatric to adult healthcare. Health care transition (HCT) represents a critical period associated with increased healthcare utilizations and a heightened risk of mortality. Although structured transition programs have been implemented in high-income countries (HICs), transition readiness remains largely unaddressed in low- and middle-income countries (LMICs), including Brazil. The dissertation aims to assess the burden of SCD, identify the …

Assessment In Conversational Intelligent Tutoring Systems: Investigating The Incremental Value Of Dialogue Moves In Electronixtutor, Colin M. Carmon

Electronic Theses and Dissertations Archive

In conversation-based intelligent tutoring systems (ITS), the student is asked challenging questions and there is a multiturn conversation between the computer tutor and the student in constructing an answer to the question. The initial student response after the question provides some information on what the student knows, whereas follow-up contributions of the student presumably extract more of what the student knows. This dissertation investigates the incremental value of follow-up dialogue moves in a conversation-based ITS, specifically ElectronixTutor, a prototype system that has been used in U.S. Navy electronics training. The research addresses two key questions: (1) What is the added …

April 23, 2025, Faculty, Illinois Wesleyan University

2024-2025

No abstract provided.

Front Matter, Harry Denny

The Writing Center Journal

Front matter and editors' introduction to The Writing Center Journal 43:1 (2025).

Writing Confidence: Tutoring, Identity, And Race—A Mixed-Methods Approach, Daniel Messier, Hadi Riad Banat

The Writing Center Journal

This mixed-methods study sought to better understand how confidence in writing and race interact as factors within writing centers. Students utilizing our writing center were asked to provide data about racial identity and writing confidence both when registering with the writing center and when completing postsession surveys. From this data, we interviewed a racially representative pool of respondents to better understand their definitions of confidence and the identity factors that have shaped their confidence in writing. Our survey data showed that students’ confidence increased significantly as a result of a writing center session, replicating previous writing center research. Furthermore, we …

Somewhere In The Middle: Assistant Directors’ Leadership, Labor, And Power In Writing Centers, Keri L. Carter, John L. Carter

The Writing Center Journal

The position of writing center assistant director resides in the middle of the often blurry lines of hierarchy. While many writing centers advocate for team leadership, the fact remains that universities are steeped in bureaucratic tradition familiar to university leaders, students, and tutors. Assistant directors accomplish tasks that keep the day-to- day center functioning, yet these tasks equate to sometimes invisible work in the center and often invisible work in the university as a whole. Furthermore, research on assistant directors’ roles, labor, and identities is exceedingly limited. Thus, the purpose of this qualitative, phenomenological study is to understand how hierarchies …

English Writing Centers In China: Opportunities, Challenges, And Paths Forward, Bradley Hughes, Jingtian Zhang

The Writing Center Journal

English writing centers at Chinese universities present a fascinating paradox. On one hand, the number of universities with writing centers and the professional interest in writing centers in China have grown steadily over the past two decades. But on the other, the number of centers is still modest and only a few centers have had a significant influence on the culture of writing on their campuses, which is surprising given the vast number of universities in China and the documented need for strengthening and expanding writing instruction in English. This international research study explores the current state of English writing …

We Should Promote Genai Writing Tools For Linguistic Equity, Nathan Lindberg

The Writing Center Journal

In this essay, I suggest that we should embrace generative artificial intelligence (GenAI) writing tools, particularly chatbots (e.g., ChatGPT, Copilot, Claude), because they can enable linguistic equity by leveling the academic playing field for English as an additional language students. As writing experts, we can find ways to use this technology to enhance learning, and, since we know both student and faculty positions, we can help develop policies so such tools can be used effectively and ethically. Alternatively, we can ignore them and risk becoming irrelevant.

Acoustic Sensing With Phased Arrays Using Beamforming And Principal Component Analysis, Kevin Mckenzie

Electronic Theses and Dissertations Archive

The work presented in this thesis explores the key design parameters of microphone sensing systems for beamforming, specifically for a stationary uniform rectangular array (URA) and a drone mounted uniform line array (ULA). It explains the development of a custom audio recorder using a Field Programmable Gate Array (FPGA) with Hard Processor System (HPS), using a unique distribution of Linux called NixOS. It details experiments conducted to characterize these systems in controlled environments like a wind tunnel and an anechoic chamber, as well as in the field for real-world testing. It also investigates methods for the autonomous detection of sound …

Brief Of Amici Curiae 775 Law Professors In Support Of Plaintiff's Motion For Summary Judgment And Declaratory And Permanent Injunctive Relief, Wilfred U. Codrington Iii, Haiyun Damon-Feng, Rebecca Ingber, Rachel Landy, Jacob Noti-Victor, Alexander A. Reinert, Anthony J. Sebok

Amicus Briefs

Amicus curiae brief submitted by 775 law professors in support of Susman Godfrey LLP's motion for summary judgment and request for declaratory and permanent injunctive relief in Susman Godfrey LLP v. Executive Office of the President. The brief argues that Executive Order 14263 unlawfully targets a law firm based on its clients, advocacy, and litigation activities, in violation of the First Amendment, Fifth Amendment, and Sixth Amendment. The amici contend that the order constitutes impermissible viewpoint discrimination, interferes with the right to counsel, and threatens the independence of the legal profession and the rule of law.

Midweek Memo, Georgia Southern University

Midweek Memo

• Applaud
• Remember
• Share
• Experience
• Around the Nest

Change And Becoming: What Is The Fundamental State Of Being?, The Philosophical Discussion Group

The Philosopher's Stone

• Change and Becoming: What is the Fundamental State of Being?

Thinking Beyond Association Tests: Using Mathematical Models To Identify Genes Influencing Exceptional Longevity, Sandeep Acharya

McKelvey School of Engineering Graduate Student Theses & Dissertations

The main goal in the genetic study of trait biology is to identify genetic factors, such as variants and genes, that causally influence traits and to understand the downstream mechanisms through which they exert their effects. This dissertation improves our understanding of trait biology by building on widely applied omics-wide association studies (omics-WAS), such as GWAS and TWAS, and proposing methods that (1) combine association statistics from multiple omics modalities and (2) systematically incorporate prior knowledge from biological networks and functional annotations with omics-WAS summary statistics. First, we apply meta-analysis to integrate gene-level p-values from GWAS, TWAS, and rare-variant analyses …