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149 - Cannabis Use Attitudes, Frequency, And Emotion Regulation In College Students, Riley Kawola, Bridget Maddigan Apr 2025

149 - Cannabis Use Attitudes, Frequency, And Emotion Regulation In College Students, Riley Kawola, Bridget Maddigan

GREAT Day Posters

Emotion regulation is the process through which people influence the emotions they experience and express, including the timing of emotional expression and experience (Gross, 1998b). Emotion regulation difficulties are a well-documented risk factor for substance use and misuse. Attitudes have been shown to directly impact behavior, specifically when they relate directly to the goals driving behavior (Baumeister & Finkel, 2010). When experiencing difficult or intense emotions, one may shift their attitudes to align with emotion regulation goals. We hypothesize that cannabis attitudes mediate the relationship between emotion regulation abilities and cannabis frequency. Participants were students (N= 72) enrolled in a …

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152 - Ion Beam Analysis Of Lithium Targets Used To Measure Laser-Driven Nuclear Reaction Cross Sections, Shoshanna Hertz, Silas Richardson, Delvin Ramos, Liam Wilson, Michelle Woods Apr 2025

152 - Ion Beam Analysis Of Lithium Targets Used To Measure Laser-Driven Nuclear Reaction Cross Sections, Shoshanna Hertz, Silas Richardson, Delvin Ramos, Liam Wilson, Michelle Woods

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A project is underway to develop a platform for measuring light ion nuclear reaction cross sections at the Laboratory for Laser Energetics (LLE) using beams of particles produced by the target normal sheath acceleration (TNSA) mechanism. This technique could enable the measurement of nuclear reaction cross sections that are not accessible with conventional accelerators. One reaction currently under investigation to test the feasibility of this technique is the 7Li(d,p)8Li reaction. The deuteron beam, produced by TNSA, is incident on a lithium target producing the radioactive isotope 8Li with a half life of 840 ms. Counting the resulting activity of the …

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158 - Devonian Nowakia From The Genundewa Limestone, Upper Devonian, Western New York, Emma Johnson, Liam Mcaneney, Chloe Rayburn, Rory Salter, Colleen Strong Apr 2025

158 - Devonian Nowakia From The Genundewa Limestone, Upper Devonian, Western New York, Emma Johnson, Liam Mcaneney, Chloe Rayburn, Rory Salter, Colleen Strong

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Nowakia are microscopic conical fossils of unknown affinities, possibly mollusks, characterized by an ornament of rings and ridges. Nowakiids have been found and studied in Devonian limestones from the Czech Republic and China, but not specifically from the Genudewa Limestone in western New York. Our goal was to quantify the abundance of nowakiids and other dacryoconarids from the upper and lower beds of the Genundewa limestone. Rock samples were collected at both Eighteen Mile Creek near North Evans, and Jones Bridge Road near Geneseo. Materials were collected using chisels and sledge hammers, then crushed, split, and scanned using optical microscopes …

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163 - New York State Agriculture And Dairy Policy, Delaney Livermore Apr 2025

163 - New York State Agriculture And Dairy Policy, Delaney Livermore

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Due to barriers set in place by various state agriculture policies, small dairy farmers in New York have a hard time making a profit, and staying afloat in the industry. As a result, it can be difficult to make dairy farming a career as a smaller dairy farmer, as the labor intensive work doesn’t have as many benefits as other careers do in today's society. However, the dairy industry isn’t growing, it’s just becoming more capitalized. With the rise of corporate farming, and the decrease in small/local farming, there is less diversity in the industry. This leads to a multitude …

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166 - Building A Youth Fellows Research Program For The Good Food Buffalo Coalition, Emmagrace Humbert Apr 2025

166 - Building A Youth Fellows Research Program For The Good Food Buffalo Coalition, Emmagrace Humbert

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What might the Good Food Buffalo Coalition’s (GFCB) key components of a youth fellows program look like? The GFCB has firmly grounded their work in their principles of prioritizing people's access to “healthy food and food that values workers, animals, and the environment, while lifting local communities out of poverty”. GFCB is currently working to build out a youth research fellows' program to secure the inclusion of the most impacted communities in the research processes so that there isn’t a need for outside folk to come and do it. Youth fellows' programs have several benefits to the community, those involved, …

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169 - Knights’ Harvest Pantry: Suny Geneseo's On-Campus Food Pantry, Matthew Mcgowan, Fiona Foley, Grace Sutherland, Talia Weidberg Apr 2025

169 - Knights’ Harvest Pantry: Suny Geneseo's On-Campus Food Pantry, Matthew Mcgowan, Fiona Foley, Grace Sutherland, Talia Weidberg

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Knights’ Harvest Pantry (previously known as The Pantry at Geneseo) is a recent addition to the SUNY Geneseo campus, beginning operation only as recently as 2021. On the Geneseo campus, students are finding that they are having issues securing food to sustain themselves on a weekly basis. Addressing this issue should be a top priority on campus, as student’s who are food insecure tend to have a lower graduation rate and are less likely to obtain an undergraduate degree. Through funding provided through grants from the SUNY system, our team looked to increase the number of pantry users, increase the …

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173 - Isolation & Rna Sequencing Of An N. Crassa Fsd-1 Dna Binding Domain Mutant Strain, Sophia Bahm, Leila Doerrer Apr 2025

173 - Isolation & Rna Sequencing Of An N. Crassa Fsd-1 Dna Binding Domain Mutant Strain, Sophia Bahm, Leila Doerrer

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Neurospora crassa is a model filamentous fungus that is widely used in a variety of genetics research. It is a reproductively versatile organism, with the ability to reproduce both sexually and asexually. N. crassa leaves many questions unanswered in regards to its mating behaviors. Specifically, we focus on how the transcription factor fsd-1 regulates mating behaviors of this fungus. Expression of fsd-1 allows for successful mating whereas strains with a deletion of fsd-1 (Δfsd-1) are functionally sterile. The focus of this study is the isolation of RNA from a mutant strain of Neurospora crassa containing a variant of the fsd-1 …

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175 - Investigating G Quadruplex Interactions In Oncogenes Using Benzothiazoles, Benzoquinone, And Benzoxazoles, Hope Mirabito, Christopher Bulan Apr 2025

175 - Investigating G Quadruplex Interactions In Oncogenes Using Benzothiazoles, Benzoquinone, And Benzoxazoles, Hope Mirabito, Christopher Bulan

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G-quadruplex (G4) DNA has become of increasing interest to the scientific community as anticancer therapies. This intrigue is due mainly to the fact that G4 DNA represents viable targets to inhibit the telomerase enzyme and to block the expression of cancer promoting oncogenes such as c-MYC, RAS and BCL-2. This makes G4 DNA a viable target for anticancer therapeutics to treat previously “undruggable” genes targets. Inspired by natural products, researchers have synthesized benzothiazoles and benzoxazoles, heterocyclic compounds that have been shown to exhibit a broad range of anti-cancer, anti-pathogenic, anti-convulsant, anti-inflammatory, and anti-tubercular bioactivity. The benzothiazole core represents a versatile …

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184 - Characterization Of Cytosolic Malate Dehydrogenase Of Trypanosoma Brucei, Grace Sutherland, Varuni Jamburuthugoda, Ellis Bell Apr 2025

184 - Characterization Of Cytosolic Malate Dehydrogenase Of Trypanosoma Brucei, Grace Sutherland, Varuni Jamburuthugoda, Ellis Bell

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The malate dehydrogenase (MDH) enzyme is found in a multitude of organisms functioning in the last step of the TCA cycle. MDH conducts the two-way reaction of malate and NAD+ to oxaloacetate and NADH (1). In humans, there are two major isoforms, cytosolic and mitochondrial. Deeper understanding of the MDH enzyme can expand treatments for parasitic diseases such as African Sleeping disease caused by T.brucei infection. Regulation of parasitic MDH gives the ability to limit the success of infection by inhibiting the protein’s ability to function (2). Since MDH can be controlled through competitive inhibition, drug discovery for T.brucei is …

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185 - Nonviolent Pedagogy: Reimagining Undergraduate Philosophy Education, Alexis Flint Apr 2025

185 - Nonviolent Pedagogy: Reimagining Undergraduate Philosophy Education, Alexis Flint

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Traditional undergraduate philosophy education (UGPE) often prioritizes dominant historical viewpoints (DHVs) while marginalizing less commonly taught philosophies (LCTPs). This exclusion creates epistemic injustices, limiting student engagement, agency, and opportunities for meaningful contributions to philosophical discourse. My research explores how incorporating principled nonviolence into pedagogy can address these systemic limitations. Nonviolent Pedagogy (NVP) is an approach that fosters dialogical learning, student agency, and epistemic justice by modifying traditional curricular structures and instructional methods. This framework draws on the Kingian model for nonviolent social change, ungrading methodologies, and inclusive epistemological frameworks to create a more participatory learning environment. Through intentional leadership and …

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187 - Exposure To Thc Throughout Adolescence Produces Long-Term Deficits In An Object Recognition Task In Rats, Hermei Herman, Marianna Santabarbara, Sarah Gusefski, Charlie Wilson Apr 2025

187 - Exposure To Thc Throughout Adolescence Produces Long-Term Deficits In An Object Recognition Task In Rats, Hermei Herman, Marianna Santabarbara, Sarah Gusefski, Charlie Wilson

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With the recent legalization of cannabis across various states, it is becoming more accessible for both medicinal and recreational usage. However, within the medical community, there has been a rise in the possible adverse health concerns of the recent emergence of its recreational use. Tetrahydrocannabinol (THC), is one of the 113 cannabinoid compounds that are more commonly used for its medicinal purposes to treat certain medical conditions, alleviating symptoms of nausea, lack of appetite, and bodily pain. Yet, THC is still largely used recreationally, and one of the primary users are adolescents. The long-term effects of THC exposure are still …

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191 - Renewal Of The Arboretum Kiosk 1, Ella Hinckley, Kaitlin Carbone, Kayla Forthman Apr 2025

191 - Renewal Of The Arboretum Kiosk 1, Ella Hinckley, Kaitlin Carbone, Kayla Forthman

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The purpose of this project is to create a resource for those who visit the Spencer J. Roemer Arboretum, a natural area preserved on the south side of campus. The information on the entrance kiosk has not been updated since 2013. By renewing the kiosk at the front of the Arboretum, visitors will have easy access to updated information including a trail map, trail conditions, native and invasive species, potentially harmful species, trail etiquette, and the history and purpose of the Arboretum. In the fall, we did extensive research on nature interpretation and the parts of the kiosk that required …

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192 - Renewal Of The Arboretum Kiosk 2, Ella Hinckley, Kaitlin Carbone, Kayla Forthman Apr 2025

192 - Renewal Of The Arboretum Kiosk 2, Ella Hinckley, Kaitlin Carbone, Kayla Forthman

GREAT Day Posters

The purpose of this project is to create a resource for those who visit the Spencer J. Roemer Arboretum, a natural area preserved on the south side of campus. The information on the entrance kiosk has not been updated since 2013. By renewing the kiosk at the front of the Arboretum, visitors will have easy access to updated information including a trail map, trail conditions, native and invasive species, potentially harmful species, trail etiquette, and the history and purpose of the Arboretum. In the fall, we did extensive research on nature interpretation and the parts of the kiosk that required …

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194 - Wetland Restoration Using Leaf-Litter Compost And Mosses: Using Shannon Diversity, Floristic Quality Analysis, & C:N Ratios To Determine Effectiveness, Talia Weidberg Apr 2025

194 - Wetland Restoration Using Leaf-Litter Compost And Mosses: Using Shannon Diversity, Floristic Quality Analysis, & C:N Ratios To Determine Effectiveness, Talia Weidberg

GREAT Day Posters

Natural wetlands provide ecosystem services such as carbon storage and biodiversity habitat. Anthropogenic impacts have degraded and destroyed wetlands, leading to loss of these services. Finding optimal restoration strategies is essential to recovering these ecosystem services and mitigating climate change. This study focuses on the change in the plant community over time; determining species composition, species diversity, and overall plant quality (FQA and C:N) in one created wetland under experimental conditions in which leaf-litter compost was added and one nearby natural forested wetland. The created wetland was divided into four transects (4 x 50 meters), two of which were kept …

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196 - Perfectionist Self-Presentation And Social Media Motives As Mediators Of Narcissism And Problematic Social Media Use, Gabrielle Diverde, Nieve Mahood, Anna Arehart, Kaela Dimanlig Apr 2025

196 - Perfectionist Self-Presentation And Social Media Motives As Mediators Of Narcissism And Problematic Social Media Use, Gabrielle Diverde, Nieve Mahood, Anna Arehart, Kaela Dimanlig

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According to the Compensatory Internet Use Theory (Kardefelt-Winther, 2014), individuals may use social media to compensate for challenges they may experience socially and/or to meet certain psychological or emotional needs. This compensation may increase the risk of problematic social media use, including addiction and stalking behavior. Researchers have linked both grandiose narcissism (exhibitionism, self-importance, and reflecting self-perceptions of grandiosity and dominance) and vulnerable narcissism (hypersensitivity to the opinions of others, defensiveness, and insecurity) to problematic social media behaviors. We examined both grandiose and vulnerable narcissism as predictors of social media stalking and addiction, with perfectionistic self-presentation and social media motives …

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200 - Topographical Individualized Neuromarkers In Children With And Without Attention-Deficit/ Hyperactivity Disorder, Julia Massoni, Grant Edmondson, Natalie Riedy Apr 2025

200 - Topographical Individualized Neuromarkers In Children With And Without Attention-Deficit/ Hyperactivity Disorder, Julia Massoni, Grant Edmondson, Natalie Riedy

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The Topographical Individualized Neuromarkers (TIN) project uses an innovative approach to analyze topographical patterns of brain function to discover biomarkers for mental health. In previous studies, neurotypically developing children show a distinct nonlinear connectivity pattern from the Anterior Cingulate Cortex (ACC) to the insula, with a maximum at the mid-dorsal ACC, compared to those at risk for anxiety who show a decreased, more linear pattern within these regions (Taber-Thomas et al., 2016). In the current study, we focus on the topographical functional connectivity patterns in children with attention-deficit/ hyperactivity disorder (ADHD) across the limbic system, a composition of different neural …

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203 - Investigating The Impact Of Invasive Mussels On Ecosystem Dynamics In Conesus Lake, Jacey Balcarczyk, Zander Cole, Kurt Schirrmacher, Emily Szczublewski, Jacalyn M. Wittmer Apr 2025

203 - Investigating The Impact Of Invasive Mussels On Ecosystem Dynamics In Conesus Lake, Jacey Balcarczyk, Zander Cole, Kurt Schirrmacher, Emily Szczublewski, Jacalyn M. Wittmer

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This study examines how invasive mussels influence ecosystem dynamics in Conesus Lake, the westernmost Finger Lake in New York. Conesus Lake has experienced cultural eutrophication, remediation efforts, and ongoing challenges such as hypoxia, harmful algal blooms, and invasive species such as Dreissena polymorpha and Dreissena bugensis. Using lake sediment archives, this study analyzes invasive mussel body size and morphology over time to assess their ecological impacts. Two 150 cm sediment cores from the south basin were analyzed using a Geotek multi-sensor core logger. Sub-fossilized mussel shells were identified to species level, and body size metrics—including length, height, and dorsal curvature—were …

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206 - Identities And Nesting Patterns Of Cavity-Nesting Bees And Wasps, Julia Lingenfelter, Sophia Stang, Carly Wick Apr 2025

206 - Identities And Nesting Patterns Of Cavity-Nesting Bees And Wasps, Julia Lingenfelter, Sophia Stang, Carly Wick

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Cavity-nesting bees and wasps lay eggs in hollow stems or other pre-made cavities and provision their larvae with food to overwinter until their emergence in spring. To observe nesting patterns, we placed nesting boxes containing “bee tubes” made of hollow reeds in five locations around the SUNY Geneseo campus. We photographed the tubes once a week over the summer, as the tubes were gradually sealed off by insects to form larval cells. We noted the type of material used to fill the tubes and analyzed the trends in the phenology and site preferences of the various fill types using the …

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211 - Evaluating The Differences In Ecosystem Services Provided By Native And Non-Native Suny Geneseo Trees, Abigail Miller, Joshua Lefkowicz, Nathan Walz Apr 2025

211 - Evaluating The Differences In Ecosystem Services Provided By Native And Non-Native Suny Geneseo Trees, Abigail Miller, Joshua Lefkowicz, Nathan Walz

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Many of the trees planted on SUNY Geneseo’s campus are for aesthetic purposes, but also provide many benefits to campus. The trees help to avoid stormwater runoff, remove air pollutants, sequester carbon dioxide, and have the ability to host lepidoptera species. iTree Design is a platform that enables investigators to estimate ecosystem services provided by trees on SUNY Geneseo campus, based on their species and size - diameter at breast height (DBH). It also estimates future ecosystem services. In part of an ongoing research project, ten native species and ten non-native species planted on SUNY Geneseo’s campus were measured and …

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215 - Invasive Species Shift Forest Structure And Regeneration In The Michigan Big Woods, Katelyn Starego, Alexis Ochs Apr 2025

215 - Invasive Species Shift Forest Structure And Regeneration In The Michigan Big Woods, Katelyn Starego, Alexis Ochs

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Invasive species disrupt ecosystems by competing with native plants for nutrients, leading to changes in forest biodiversity. These invasive species often lead to competitive exclusion, in which the invasives outcompete the natives for dominance. Some native species, however, show different abilities for dealing with these types of stresses. We investigated the impacts of invasive species for the Michigan Big Woods plot in Pinckney, MI, where invasive species such as Berberis thunbergii (Japanese Barberry) and Elaeagnus umbellata (Autumn Olive) are flourishing. We explored the interactions between invasive species and native tree species, especially Quercus rubra (Red Oak), Quercus alba (White Oak), …

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216 - Location Of Sonic Hedgehog Signaling In The Regenerating Zebrafish Retina., Adam Snyder Apr 2025

216 - Location Of Sonic Hedgehog Signaling In The Regenerating Zebrafish Retina., Adam Snyder

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The Sonic Hedgehog protein (Shh) is required in the cell cycle for development and regeneration in zebrafish eyes. This is because it controls how cells differentiate into specialized cell types. The gene, ptch2, is also important due to it being a component of the Shh signaling. The retina needs to replace photoreceptors, a specific cell type of the retina, after it is damaged by light. It is unknown which retinal cells produce Shh. To detect which cells that express the shh and ptch2 mRNA, we plan to perform in situ hybridization using antisense probes on regenerating retinal sections and compare …

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220 - Personal Distress And Empathetic Concern Mediate The Relationship Between Connectedness To Nature And Environmentally Friendly Behavior, Alex Gaboury, Anthony Carvalho Apr 2025

220 - Personal Distress And Empathetic Concern Mediate The Relationship Between Connectedness To Nature And Environmentally Friendly Behavior, Alex Gaboury, Anthony Carvalho

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Previous research shows that connectedness to nature and empathy predict environmentally friendly behaviors and intentions. However, mediators within this relationship remain unclear. We suspect that the role of emotions and distress is important, specifically given today's environmental problems and their influence on individual’s well-being and then on their environmental actions. This leads us to the hypothesis that connectedness to nature would predict environmentally friendly behaviors through sequential serial mediators of personal distress and empathetic concern. We tested this hypothesis using a sample of college students at a public liberal arts college who completed a lengthy questionnaire with various environmental questions …

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222 - A Land Use History Of The Hemlock-Canadice State Forest Through Gis, Meghan Viola Murphy Apr 2025

222 - A Land Use History Of The Hemlock-Canadice State Forest Through Gis, Meghan Viola Murphy

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This project is a comprehensive land-use history of the Hemlock-Canadice State Forest through a series of maps and information compiled with GIS technology. The use of LiDAR-derived digital elevation models was central, enabling the mapping of historical features through visible differences in elevation. When combined with the use of georeferenced historical maps, the location and shape of still-present features indicating historical activity were identified and mapped. These include the foundations of cottages, old roads, skid trails from logging, and plow lines, which remain even after over 100 years.

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223 - Color Alteration Of Conodonts From The Upper Devonian To Lower Mississippian, Ethan Gilfus, Jamie Mccarthy, Ryan Britt Apr 2025

223 - Color Alteration Of Conodonts From The Upper Devonian To Lower Mississippian, Ethan Gilfus, Jamie Mccarthy, Ryan Britt

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Three conodont bearing samples from Mount Morris, New York, San Saba, Texas, and Pi, Spain were processed using 10% formic acid buffered with calcium carbonate and calcium phosphate to compare age, preservation, and burial depth as indicated by the Color Alteration Index. The Shurtleff Concretion Horizon in the upper Cashaqua Formation of the Sonyea Group from Mount Morris, New York, yielded a fauna of exceptionally well preserved Frasnian conodonts that are CAI 2.5. Pi-01 limestone from Pi, Spain, within the Barousse Formation yielded poorly preserved Upper Famennian conodonts that are CAI 5. Type Chappel limestone from San Saba, Texas, yielded …

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229 - Power Dynamics In Close Peer Relationships: Associations With Adjustment, Lily Finnegan, Grace Morichelli, Elise Cleary Apr 2025

229 - Power Dynamics In Close Peer Relationships: Associations With Adjustment, Lily Finnegan, Grace Morichelli, Elise Cleary

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Very little research has examined power in peer relationships, as they are assumed to be egalitarian (Blieszner & Adams, 1992). Although this is generally found to be true for college students (Furman & Buhrmester, 1992), this isn’t always the case. In romantic relationships, having equal power or more power has been associated with higher self-esteem (Galliher et al., 1999; Hall & Knox, 2019). This presentation highlights preliminary analyses from an ongoing project examining associations between perceived power and adjustment among college students in their same-sex friendships, other-sex friendships, and romantic relationships. We used cluster analysis to group the students into …

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230 - Examination Of Gold Colloid Aggregate Formations Within The Hippocampus Of The Alzheimer’S Disease Rat, Victoria Brzezinski, Kazushige Yokoyama Apr 2025

230 - Examination Of Gold Colloid Aggregate Formations Within The Hippocampus Of The Alzheimer’S Disease Rat, Victoria Brzezinski, Kazushige Yokoyama

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An entire section of the hippocampus of the Long Evans Cohen's Alzheimer’s disease, AD(+), rat model was examined utilizing the Surface Enhanced Raman Scattering (SERS) spectrum to study gold aggregates. An examination of normal rat, AD(-), tissues was also performed as a comparison and negative control. In the AD(+) rat hippocampal tissues, a limited quantity of larger gold colloid aggregates were identified. The SERS spectrum of each section in the hippocampus exhibited nearly identical spectral patterns in the region of Amide I, II, and III bands, as well as distinct spectral patterns in the 300 cm–1 and 1250 cm–1 region …

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231 - Investigation Of Ace 2 On Sars-Cov-2 Spike Protein Coated Gold Colloids, Mitsuki Tabei, Nathan Boboeski Apr 2025

231 - Investigation Of Ace 2 On Sars-Cov-2 Spike Protein Coated Gold Colloids, Mitsuki Tabei, Nathan Boboeski

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The RBD (Receptor Binding Domain) of spike protein (s-protein) in SARS-CoV-2 virus is highly associated with priming the viral infection, where N-terminal helices and its adjacent loop of ACE2 (Angiotensin Converting Enzyme 2) is bound to s-protein. We investigated a protein corona formation of s-protein over gold nano-colloids and reversible aggregation process as a function of pH change between acidic condition (i.e., pH ~3) and basic condition (i.e., pH ~11). The s-protein exhibited signs of aggregation through the unfolded conformation of RBD segments at the acidic condition. As the pH was repeatedly cycled between acidic and basic conditions, the aggregation …

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233 - Synthesis And Evaluation Of 1,10-Phenanthroline Ruthenium-Arene Complexes To Modulate The Aggregation Of The Amyloid-Β Peptide, Maria Loughlin, Emma Grabowski, Ryan Hacker, Jacob Smith Apr 2025

233 - Synthesis And Evaluation Of 1,10-Phenanthroline Ruthenium-Arene Complexes To Modulate The Aggregation Of The Amyloid-Β Peptide, Maria Loughlin, Emma Grabowski, Ryan Hacker, Jacob Smith

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Alzheimer’s Disease (AD) is a neurological disorder characterized by a buildup of the amyloid beta (Aβ) peptide as aggregate species in the brain. Recent advances using antibody based treatments which target Aβ have seen clinical success, achieving FDA approval. However, they come at a significant cost, ranging from $20,000-40,000 a year. Ruthenium-based therapeutics are promising alternatives, as they have shown an ability to modulate the aggregation of Aβ in solution and prevent its cytotoxicity. Despite their initial success, significant questions regarding the affinity of the complexes for Aβ relative to endogenous proteins remain unknown. Therefore, we have synthesized a series …

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236 - Characterization Of Reversible Aggregation Of Amyloid Beta 1-40 Coated Gold Nano-Particles, Christopher Kolilias, Victoria Brzezinski Apr 2025

236 - Characterization Of Reversible Aggregation Of Amyloid Beta 1-40 Coated Gold Nano-Particles, Christopher Kolilias, Victoria Brzezinski

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The gold colloid coated with Aβ1-40 was characterized by using the Raman imaging technique. Through the observed pH-dependent shift of the SPR (Surface Plasmon Radiance) band, it was determined that gold colloid aggregates were formed under acidic conditions.. Remarkably, Aβ1-40 coated 20 nm gold supported quasi-reversible self-assembly of the aggregates as the pH was alternated between pH 4 and pH 10. The morphology was distinctly observable between two different conditions. Nevertheless, the SERS (Surface Enhanced Raman Scattering) spectrum presented minor differences. An additional analysis displayed the contrast in spectral density in the regions of 250 cm-1 and 1750 cm-1. The …

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237 - Investigation Of Cytoskeletal Protein Reconstruction Of Vulvar Cancer With Surface-Enhanced Raman Spectroscopy, Nicole Mathewson Apr 2025

237 - Investigation Of Cytoskeletal Protein Reconstruction Of Vulvar Cancer With Surface-Enhanced Raman Spectroscopy, Nicole Mathewson

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The A431 vulvar cancer cell line undergoes a defined cellular transformation when treated with the corticosteroid clobetasol, marked by changes in cytoskeletal protein biomarkers indicative of epithelial-mesenchymal transition (EMT). Replicated experiments demonstrate that this transformation provides a valuable model for studying protein interactions from a chemical perspective. To quantify these interactions, we employed surface-enhanced Raman spectroscopy (SERS) combined with gold nanoparticles, enhancing the detection sensitivity of cytoskeletal protein changes. By tracking protein dynamics and surface composition throughout the cellular transformation, we aim to elucidate the mechanisms underlying EMT. We have completed the data collection of A431 and A431D cells. Spectral …

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