Digital Commons Network^™

Volumetric Changes In Cerebellar Transverse Zones: Age And Sex Effects In Health And Neurological Disorders, Farshid Ghiyamihoor, Payam Paymani, Jarrad Perron, Azam Asemi-Rad, Mehdi Marzban, Aashka Mohite, Karen Ardila, Bara Aljada, Asghar Marzban, Mehnosh Toback, Sherif Eltonsy, Ji Hyun Ko, Tabrez J Siddiqui, Christopher J Steele, Jiming Kong, Mario Manto, M Ethan Macdonald, Jason S Gill, Roy V Sillitoe, Fuat Balcı, Iman Beheshti, Hassan Marzban

Duncan NRI Faculty and Staff Publications

Cerebellar volumetric changes are intricately linked to aging, with distinct patterns across its transverse zones, the functional subdivisions characterized by unique cytoarchitectural and connectivity profiles. Despite research efforts, the cerebellar aging process in health and neurological disorders remains poorly understood. In this study, we investigated the effects of age and sex on total cerebellum, transverse zone, and lobule volumes using MRI data from over 45,000 participants compiled from six neuroimaging datasets. We also propose a framework for estimating cerebellum age as an indicator of cerebellar health. Significant age‐dependent volume reductions were observed across transverse zones, with the …

Distinguishing Multisystem Inflammatory Syndrome In Children From Typhus Using Artificial Intelligence: Mis-C Versus Endemic Typhus (Ai-Met), Angela Chun, Abraham Bautista-Castillo, Isabella Osuna, Kristiana Nasto, Flor M Munoz, Gordon E Schutze, Sridevi Devaraj, Eyal Muscal, Marietta M De Guzman, Kristen Sexson Tejtel, Tiphanie P Vogel, Ioannis A Kakadiaris

Faculty, Staff and Students Publications

Background: The pandemic emergent disease multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease-19 infection can mimic endemic typhus. We aimed to use artificial intelligence (AI) to develop a clinical decision support system that accurately distinguishes MIS-C versus endemic typhus (MET).

Methods: Demographic, clinical, and laboratory features rapidly available following presentation were extracted for 133 patients with MIS-C and 87 patients hospitalized due to typhus. An attention module assigned importance to inputs used to create the 2-phase AI-MET. Phase 1 uses 17 features to arrive at a classification manually (MET-17). If the confidence level is not surpassed, 13 additional features …

Atm-Dependent Dna Damage Response Constrains Cell Growth And Drives Clonal Hematopoiesis In Telomere Biology Disorders, Christopher M Sande, Stone Chen, Dana V Mitchell, Ping Lin, Diana M Abraham, Jessie Minxuan Cheng, Talia Gebhard, Rujul J Deolikar, Colby Freeman, Mary Zhou, Sushant Kumar, Michael Bowman, Robert L Bowman, Shannon Zheng, Bolormaa Munkhbileg, Qijun Chen, Natasha L Stanley, Kathy Guo, Ajibike Lapite, Ryan Hausler, Deanne M Taylor, James Corines, Jennifer Jd Morrissette, David B Lieberman, Guang Yang, Olga Shestova, Saar Gill, Jiayin Zheng, Kelcy Smith-Simmer, Lauren G Banaszak, Kyle N Shoger, Erica F Reinig, Madilynn Peterson, Peter Nicholas, Amanda J Walne, Inderjeet Dokal, Justin P Rosenheck, Karolyn A Oetjen, Daniel C Link, Andrew E Gelman, Christopher R Reilly, Ritika Dutta, R Coleman Lindsley, Karyn J Brundige, Suneet Agarwal, Alison A Bertuch, Jane E Churpek, Laneshia K Tague, F Brad Johnson, Timothy S Olson, Daria V Babushok

Faculty, Staff and Students Publications

Telomere biology disorders (TBDs) are genetic diseases caused by defective telomere maintenance. TBD patients often develop bone marrow failure and have an increased risk of myeloid neoplasms. To better understand the factors underlying hematopoietic outcomes in TBD, we comprehensively evaluated acquired genetic alterations in hematopoietic cells from 166 pediatric and adult TBD patients. Of these patients, 47.6% (28.8% of children, 56.1% of adults) had clonal hematopoiesis. Recurrent somatic alterations involved telomere maintenance genes (7.6%), spliceosome genes (10.4%, mainly U2AF1 p.S34), and chromosomal alterations (20.2%), including 1q gain (5.9%). Somatic variants affecting the DNA damage response (DDR) were identified in 21.5% …

Left Ventricular Entry To Reduce Brain Lesions During Catheter Ablation: A Randomized Trial, Gregory M Marcus, Roderick Tung, Edward P Gerstenfeld, Trisha F Hue, Feng Lin, Jing Cheng, J Peter Weiss, Wendy S Tzou, Henry Hsia, Ashkan Ehdaie, Daniel H Cooper, T Jared Bunch, Jeffrey Arkles, Babak Nazer, Adam Lee, Alexios Hadjis, Duy T Nguyen, Mihail G Chelu, Joshua Moss, Jonathan C Hsu, Miguel Valderrábano, Prashant D Bhave, Andrew D Beaser, Arvindh Kanagasundram, Oussama Wazni, Jason Bradfield, Grace Wall, Kathleen Chang, Michelle Yang, Gabrielle Montenegro, Sabrina Jarrott, Joel H Kramer, Anthony S Kim, Yvonne M Morris, William P Dillon

Faculty, Staff and Students Publications

Background: Catheter ablation of ventricular arrhythmias, one of the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging-detected brain lesions in more than half of cases. Although a retrograde aortic approach is conventional, modern tools enable entry through a transseptal approach that may avoid embolization of debris from the arterial system. We sought to test the hypothesis that a transseptal puncture would mitigate brain injury compared with a retrograde aortic approach.

Methods: The TRAVERSE trial (Transseptal Versus Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli) was a multicenter randomized controlled comparative effectiveness trial. Patients with left …

Atm-Dependent Dna Damage Response Constrains Cell Growth And Drives Clonal Hematopoiesis In Telomere Biology Disorders, Christopher M. Sande, Karolyn A. Oetjen, Daniel C. Link, Andrew E. Gelman, Laneshia K. Tague, Et Al.

2020-Current year OA Pubs

Telomere biology disorders (TBDs) are genetic diseases caused by defective telomere maintenance. TBD patients often develop bone marrow failure and have an increased risk of myeloid neoplasms. To better understand the factors underlying hematopoietic outcomes in TBD, we comprehensively evaluated acquired genetic alterations in hematopoietic cells from 166 pediatric and adult TBD patients. Of these patients, 47.6% (28.8% of children, 56.1% of adults) had clonal hematopoiesis. Recurrent somatic alterations involved telomere maintenance genes (7.6%), spliceosome genes (10.4%, mainly U2AF1 p.S34), and chromosomal alterations (20.2%), including 1q gain (5.9%). Somatic variants affecting the DNA damage response (DDR) were identified in 21.5% …

Cerebrospinal Fluid Proteomics Identification Of Biomarkers For Amyloid And Tau Pet Stages, Zhibo Wang, Yuhan Chen, Katherine Gong, Bote Zhao, Yuye Ning, Meilin Chen, Yan Li, Muhammad Ali, Jigyasha Timsina, Menghan Liu, Carlos Cruchaga, Jianping Jia

2020-Current year OA Pubs

Accurate staging of Alzheimer's disease (AD) pathology is crucial for therapeutic trials and prognosis, but existing fluid biomarkers lack specificity, especially for assessing tau deposition severity, in amyloid-beta (Aβ)-positive patients. We analyze cerebrospinal fluid (CSF) samples from 136 participants in the Alzheimer's Disease Neuroimaging Initiative using more than 6,000 proteins. We apply machine learning to predict AD pathological stages defined by amyloid and tau positron emission tomography (PET). We identify two distinct protein panels: 16 proteins, including neurofilament heavy chain (NEFH) and SPARC-related modular calcium-binding protein 1 (SMOC1), that distinguished Aβ-negative/tau-negative (A-T-) from A+ individuals and nine proteins, such as …

Outcomes Evidence Must Keep Up With The Implementation Of The 4ms Framework To Ensure Age-Friendly Health System Transformation, James D Harrison, Stephanie E Rogers, Benjamin Rosner, Estelle Martin, Sunny C Lin, Jarmin Yeh, Julia Adler-Milstein

2020-Current year OA Pubs

The Age-Friendly Health System (AFHS) movement was conceptualized as a transformative solution to reliably deliver evidence-based care to older adults. Guided by the 4Ms framework: What Matters, Mobility, Mentation, and Medication, AFHS healthcare systems have been given the flexibility to tailor 4Ms interventions and care processes to their context, preferences and populations. This flexibility has facilitated the widespread adoption of 4Ms care. However, as our understanding of 4Ms implementation grows, evidence of the impact of 4Ms care on outcomes must keep up with implementation to ensure AFHS transformation. It is only through assessing the 4Ms as a whole and understanding …

Synapsin Condensation Is Governed By Sequence-Encoded Molecular Grammars, Christian Hoffmann, Kiersten M Ruff, Irina A Edu, Min Kyung Shinn, Johannes V Tromm, Matthew R King, Avnika Pant, Hannes Ausserwöger, Jennifer R Morgan, Tuomas P J Knowles, Rohit V Pappu, Dragomir Milovanovic

2020-Current year OA Pubs

Multiple biomolecular condensates coexist at the pre- and post- synapse to enable vesicle dynamics and controlled neurotransmitter release in the brain. In pre-synapses, intrinsically disordered regions (IDRs) of synaptic proteins are drivers of condensation that enable clustering of synaptic vesicles (SVs). Using computational analysis, we show that the IDRs of SV proteins feature evolutionarily conserved non-random compositional biases and sequence patterns. Synapsin-1 is essential for condensation of SVs, and its C-terminal IDR has been shown to be a key driver of condensation. Focusing on this IDR, we dissected the contributions of two conserved features namely the segregation of polar and …

Immunotherapeutic Strategies In Head And Neck Cancer: Challenges And Opportunities, Xia Liu, R. Alex Harbison, Mark A. Varvares, Sidharth V. Puram, Guangyong Peng

2020-Current year OA Pubs

HNSCC remains a substantial health issue, with treatment options including surgery, radiation, and platinum-based chemotherapy. Unfortunately, despite progress in research, only modest gains have been made in disease control, with existing treatments resulting in significant functional and quality-of-life issues. The introduction of immunotherapy in the treatment of HNSCC has resulted in some improvements in outlook for patients and is now standard of care for populations with both recurrent and metastatic disease. However, despite the early successes, responses to immune checkpoint inhibition (ICI) remain modest to low, approaching 14%-22% objective response rates. Challenges to the effectiveness of ICI and other immunotherapies …

Understanding Implementation Determinants Of Universal School Meals Through An Equity-Driven Mixed Methods Approach, Gabriella M Mcloughlin, Molly Kerstetter, Yerusalem Yohannes, Omar Martinez, Resa M Jones, Ross C Brownson, Jennifer O Fisher

2020-Current year OA Pubs

BACKGROUND: Policies, such as Universal School Meals (USM), are essential for preventing inequities in chronic disease risk among socially and economically marginalized populations. Implementing USM reduces food insecurity and obesity risk, among other academic/health outcomes; unfortunately, across the nation student participation (i.e., reach) is lower than expected, limiting its public health impact. Grounded in implementation science and health equity frameworks, this study aimed to: 1) investigate the determinants of implementing USM in a large, urban school district and 2) assess key challenges and supports across schools with varying levels of participation in USM.

METHODS: A needs and assets assessment was …

Attitudes Of Female Carriers Of X-Linked Hypohidrotic Ectodermal Dysplasia Towards Prenatal Treatment And Their Decisions During A Pregnancy With A Male Fetus, Holm Schneider, Michael Schneider, Massimiliano Lia, Dorothy K Grange, Smail Hadj-Rabia, Angus Clarke, Mary Fete, Agnes Jaulent, Marlene Guiraud, Anthony Odibo, Florian Faschingbauer

2020-Current year OA Pubs

BACKGROUND: X-linked hypohidrotic ectodermal dysplasia (XLHED) is a severe genetic disorder that may be treatable with short-term protein replacement therapy during fetal development. This is currently being investigated in a multicenter clinical trial. Affected fetuses can be identified by the number of tooth germs during a routine ultrasound scan in mid-gestation. To understand the attitudes of female XLHED carriers towards prenatal treatment and ultrasonographic screening of the fetus, we analyzed an earlier and a very recent survey among those women and the actual decisions of potential trial participants.

METHODS: Initial analyses were based on a self-administered survey of 167 female …

Mri Distance Measures As A Predictor Of Subsequent Clinical Status During The Preclinical Phase Of Alzheimer's Disease And Related Disorders, Xinyi Zhang, John C Morris, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

Brain atrophy over time, as measured by magnetic resonance imaging (MRI), has been shown to predict subsequent cognitive impairment among individuals who were cognitively normal when first evaluated, indicating that subtle brain atrophy associated with Alzheimer's disease (AD) may begin years before clinical symptoms appear. Traditionally, atrophy has been quantified by differences in brain volume or thickness over a specified timeframe. Research indicates that the rate of atrophy varies across different brain regions, which themselves exhibit complex spatial and hierarchical organizations. These characteristics collectively emphasize the need for diverse summary measures that can effectively capture the multidimensional nature of degeneration. …

Distributed Serving Of Partitioned Machine Learning Models Across Heterogeneous Hardware Resources, Vince Gatto, Junyan Li, Chi Chen, Hang Fu, Brad Froehle, Smit Hinsu, Devanshu Jain, Aniruddh Nath, Ruolin Jia, Shuo Chang, He Ma, Daokun Jiang

Defensive Publications Series

The present disclosure relates to systems and methods for serving machine learning models by partitioning model components for distributed execution across heterogeneous hardware resources. In particular, the disclosure describes techniques for splitting models into independently executable subgraphs deployed across a cluster of machines with varying hardware configurations (e.g., CPUs, GPUs, TPUs). The system leverages the distinct strengths of different hardware types by mapping memory-intensive or preprocessing-heavy components to CPU machines, while assigning compute-intensive subgraphs to accelerators such as TPUs. The distributed architecture employs a runtime system that manages inter-machine communication and orchestration of inference tasks, enabling improved utilization, scalability, and …

Camera Captured Board Analysis Aids For Meeting Transcription And Post-Meeting Summarization, Jieyu Tan, Soya Li, Espen Berger, Hilary Liu

Defensive Publications Series

Presented herein is an approach for utilizing "board focus" techniques to extract information from attendees' handwritten notes during an online video conference or meeting. This approach can enhance the accuracy for generating meeting transcriptions (e.g., regarding language type, special terms, abbreviations, acronyms, etc. used during a meeting) and also meeting summaries (e.g., regarding structural element identification) as compared to conventional transcription/summary techniques that typically rely on audio streams.

Subsea Chemical Storage And Injection Systems, Baker Hughes Company

Defensive Publications Series

The conventional Chemical Injection System (with topside supply tanks and long Umbilical for delivering the chemicals to subsea components) has the following drawbacks:

• High CAPEX cost of the chemical injection system.
• Additional potential leakage in the long umbilicals.
• Longer response time.
• Requires larger chemical volume to fill the long umbilicals – adding cost and leakage risks
• Requires larger topside pumps in some cases in shallow water and long umbilical laying on the seabed.
• Does not use electrical control valves.
• Not consisting of Module Design – not a sizable system.

A system design is proposed to address the above requirement

An Autoethnographic Account Of The Dimensions Of Learning To Teach, Angela Reyes-Carrasquillo, Diane Rodríguez

Journal of Multilingual Education Research

This is a review of the book Navigating Teacher Education in Complex and Uncertain Times by Carmen I. Mercado. The volume offers an autoethnographic narrative of an innovative learning and teaching process in teacher training including her role as a professor responding to the needs of the urban diverse students and their families served. It is an ethnographic contribution where Mercado’s life and work are intertwined. Through a rich autobiographical account, spanning 40 years, Mercado theorizes from her experiences as a teacher and teacher educator, offering powerful lessons to teachers and teachers’ educators alike.

Career Long Scholarly Contributions To Educating Teachers For Multilingual Classrooms And Exploring Multilingualism, Yidan Shao, Patricia M. Velasco

Journal of Multilingual Education Research

No abstract provided.

¿Y Ahora Qué? Interest Convergence And Hope Through Provision, Promotion, And Partnerships In Two-Way Dual Language Programs, Mitch Ingram, Charise Pimentel

Journal of Multilingual Education Research

As Two-Way Dual Language Programs continue in their nascent stages in the United States, some teachers, administrators, and researchers have reported issues of interest convergence. In this article, two researchers work alongside a bilingual pre-service teacher to highlight three such examples: the business of learning a language, Latin@ Spanish-speaking students used as resources, and the gentrification of bilingual education. Beyond the diagnosis of such dilemmas, we offer a preliminary framework and some promising tenets of hope to overcome any such asymmetries that can exist when interested families from different social locations agree to collaborate in the journey of dual language …

Sociocultural Predictors Of Children’S Papiamento And Dutch Reading Literacy In The Dutch Caribbean, Melissa Van Der Elst-Koeiman, Eliane Segers, Ronald Severing, Ludo Verhoeven

Journal of Multilingual Education Research

This study examined how Papiamento and Dutch attitude and home literacy environment of 168 children in fourth grade of the post-colonial Dutch Caribbean, predicted L1 and L2 reading literacy in sixth grade. Overall, children had higher scores for reading literacy in L1 Papiamento as compared with L2 Dutch. They showed more positive attitudes towards their mother tongue, regarding language use, reading, and media use. Furthermore, literacy activities at home were more frequent in L1 than in L2, although they reported having more books at home in L2 than in L1. Finally, L1 home literacy activities were negatively related to L1 …

Description And Publishing Guidelines

Journal of Multilingual Education Research

No abstract provided.

Life Long Perspectives On The Multilingual Experience, Annie Shaba

Journal of Multilingual Education Research

Multilingualism Across the Life Span is a text that explores the subject of language diversity and multilingualism across an individual’s lifespan and their community. Edited by Unn Røyneland and Robert Blackwood, the book features co-authored chapters that look into the complexities of linguistic diversity, multilingualism as a lived reality, and the non-linear trajectories of language development. The book is divided into three parts: methodological and theoretical developments in bilingual acquisition, language practices and policies in the family, and bilingual aging, communication, and cognitive impairments. It offers insights from research conducted in various parts of the world and is relevant for …

Navigating Taiwan's Bilingual 2030 Policy: Unveiling Teachers' Glocalization Efforts And Agency, Ching-Ching Lin, Ming-Hsuan Wu

Journal of Multilingual Education Research

As a strategic initiative aimed to enhance English communication skills and bolster the global competitiveness of the general population, Taiwan’s Bilingual 2030 Policy takes place at the intersection of neoliberalism, globalization, and the global spread of the English language. The neoliberal framing of Taiwan’s language education policy has exerted powerful influences on teacher education, teacher hiring practices, curricular design, assessment, and other school practices. While the neoliberalist influences are prevalent among countries in the Global South, responses and resistance may take many forms embedded in specific sociocultural contexts. The reflection discussed here examines the challenges faced by teachers in Taiwan …

Jmer Volume 13

Journal of Multilingual Education Research

No abstract provided.

Investigating The Role Of Semi-Public Open Spaces Of Housing Clusters As A Booster Of Social Interaction In Abu Dhabi Neighbourhoods, Mohammad Shuayyat

Thesis/ Dissertation Defenses

This thesis explores the relationship between urban housing cluster configurations, open space design, and social interaction in the context of Emirati neighborhoods, focusing on the Al Salamat area in Al Ain, United Arab Emirates. It aims to investigate how different residential housing cluster types—such as cul-de-sacs, perimeter blocks, linear blocks, and closed-loop configurations—shape the usability and social function of semi-public open spaces. The study integrates theoretical insights from urban planning literature with empirical findings through spatial analysis (using Depth map X), field observations, and semi-structured interviews with residents.
The research adopts a mixed-method case study approach. It begins with a …

Legal And Ethical Challenges In Home Healthcare Administration, Chidubem Xerona Nnajiofor, Isheka Francis

Liberty University Research Week

Health administrators in home healthcare face numerous legal and ethical issues that need careful management. The home healthcare industry delivers essential patient care services in residential settings while health administrators confront critical legal and ethical challenges. This research proposal seeks to explore the legal and ethical issues facing health administrators in the home healthcare industry, focusing on five primary areas: Health administrators in home healthcare must address legal and ethical challenges including eligibility criteria compliance, elder abuse and neglect cases, labor law adherence and worker rights protection as well as ethical patient care decisions along with healthcare worker overwork and …

Prm1 Influences Mating And Virulence In Cryptococcus Neoformans, Polycarp Amosun

Liberty University Research Week

Cryptococcus neoformans, an opportunistic pathogen, relies on homeostasis, environmental stability, and adaptability for its growth and survival. C. neoformans primarily infects immunocompromised individuals, increasing the propensity of invading the central nervous system. The most affected are individuals with HIV/AIDs. Recently, the World Health Organization classified C. neoformans as a Critical Priority fungal pathogen due to its widespread presence and high mortality rate. The ability to adapt to changes in environmental pH is one of the key factors contributing to C. neoformans pathogenicity. The gene CNAG_05866 was recently identified by researchers at Duke University via a mutagenesis screen to identify genes …

A Dual Approach To Carbamate Pesticides: Extraction And Determination In Camel Milk And Date Palm Fruit In The Uae, And Photocatalytic Degradation In Water, Rana Fawzi Morsi

Thesis/ Dissertation Defenses

The growing global population has led to an increasing demand for food production, necessitating the widespread use of pesticides to enhance crop yield, improve quality, and protect against pests. Among the various types of pesticides, carbamates are extensively used due to their effectiveness in controlling pests. However, their residues in food products pose serious human health risks, including neurotoxicity, genetic mutations, cancer development, and immunosuppression. Therefore, the reliable detection and quantification of carbamate residues in food are paramount to ensuring food safety and regulatory compliance.

This dissertation focuses on developing and validating analytical techniques for extracting and detecting carbamate residues …

A Quantitative Study Teaching De-Escalation With Virtual Reality Simulation To Associate Nursing Students Measuring Effectiveness, Learning, And Confidence, Michele Marbet

Liberty University Research Week

Workplace violence against nurses is a critical global public health issue, with one in four nurses reportedly experiencing physical assault by patients. This quantitative quasi-experimental, pretest-posttest study aimed to assess the effectiveness of virtual reality simulation as a teaching strategy for de-escalation education in associate nursing students (N = 29) perception in learning and confidence. The study utilized the Simulation Effectiveness Tool-Modified (SET-M) instrument to measure outcomes guided by Kolb's experiential learning theory and the NLN Jeffries simulation theory. The learning variable demonstrated significant improvement as confirmed by paired t-test analysis (p < .01). For the effectiveness and confidence variables, which violated assumptions of normality, a comprehensive statistical approach was implemented. Analysis included parametric testing via paired t-tests, supplemented by nonparametric methods (Wilcoxon Signed-ranks test and Sign test) to ensure statistical rigor. The cumulative results across all three statistical tests consistently demonstrated significant improvements (p < .001). Effect size calculations revealed medium to large significance for all variables measured by Cohen’s d. The conclusive findings of this research to reject all three null hypotheses suggest that virtual reality simulation is an effective teaching strategy for developing de-escalation skills, enhancing both learning and confidence among associate nursing students. Future studies are needed to further validate and expand upon the findings of the current research, potentially leading to more widespread adoption of virtual reality simulation in nursing education for teaching de-escalation. Keywords: Nursing education associate degree, de-escalation, virtual reality simulation, work-place violence

Genesis Flood And Tsunami Run-Up: A Study Of Zero Water Depth, Oluwafemi Samuel Dada, John Baumgardner, Mark Horstemeyer

Liberty University Research Week

This research uses the Crank-Nicolson implicit scheme in two-dimensional finite-difference codes to overcome the numerical dispersion associated with tsunami wave propagation as the water depth approaches zero at the shoreland in order to accurately measure the distance of water moving over dry land. Accurately capturing the motion of water from the deep ocean to the coastal area faces numerical dispersion resulting from modeling tsunami behavior at the shoreline, which leads to an inaccurate solution thus causing unrealistic results. This study is developing a finite difference code that uses an implicit method, like the Crank-Nicolson method, to address the numerical issues …

Modeling Ectopic Pregnancy In Murids, Thomas Hall

Liberty University Research Week

Tubal ectopic pregnancy is a condition where a conceived embryo implants in the f allopian tube leading to the uterus, rather than in the uterus itself (1). As the baby grows, the tension it puts on the wall of the fallopian tube will cause it to tear, resulting in maternal hemorrhaging and death (2). Thus, tubal ectopic pregnancies are universally terminated either by surgical removal of the fallopian tube with the baby, or by chemically inducing miscarriage (3). Tubal ectopic pregnancy rarely occurs in animals, so researchers have no high-fidelity model for testing new interventions (4). Our hypothesis is that …