Digital Commons Network^™

Closing The Gap: Addressing College Readiness Inequities Through Dual Enrollment Policy And Practice Reform, Tabytha L. Walls

All Dissertations

This dissertation employed improvement science to increase college readiness at Phosphate Grove High School by expanding the dual-enrollment program. At this research site, a majority-minority, Title I high school in South Carolina, dual enrollment serves as the primary pathway towards college readiness on the state report card. College readiness at this school has been low for many years, and participation in the program has not been representative of the school's size. Many students meet the academic eligibility requirements, but students and families are unaware of the opportunities and have difficulty navigating the sign-up process.

This study aimed to address some …

Making The Case For Historically Minoritized Students At Career Centers With A Focus On Agriculture, Janine Honey Sutter

All Dissertations

Historically minoritized students are still underrepresented in many Career and Technical Education (CTE) programs, such as agricultural education, even though these programs offer valuable academic, workforce, and postsecondary opportunities. This dissertation used Improvement Science to explore whether educator perceptions and communication practices played a role in this underrepresentation at Liberty Career Center. It also examined whether targeted informational interventions could help educators become more aware of and more positive about Career Center opportunities.

Following Improvement Science principles, the study used a continuous improvement approach to find system-level barriers and test new ways to improve communication between the Career Center and …

Teacher Self-Efficacy And Student Engagement In Rural Science, Technology, Engineering, And Mathematics Magnet Schools: A Correlational Study Within An Improvement Science Context, Deirdre L. Appleby

All Dissertations

Teacher self-efficacy in magnet-themed integration represents a critical, district-influenceable condition shaping instructional experiences in rural Science, Technology, Engineering, and Mathematics (STEM) magnet programs. Persistent under-enrollment of Black, Latinx, and economically disadvantaged students in these settings highlights ongoing inequities in access and participation that may be influenced by upstream instructional conditions. Grounded in Bandura’s Social Cognitive Theory and situated within an improvement science framework, this study examines teacher self-efficacy as a key system-level factor associated with student engagement.

This study employs a correlational research design within an improvement science context to examine the relationship between changes in teacher self-efficacy and changes …

Technology Enhanced Math Instruction And Student Achievement, Barbara Warren

All Dissertations

ABSTRACT

This study examines how one teacher in a large rural high school in South Carolina integrates an AI technological intervention as a supplemental tool, specifically as part of blended learning, to help increase math achievement for students in Geometry with Statistics.  Evidence-based interventions, such as technology enhanced math instruction, encompass a diverse range of tools used by teachers, including an AI-driven high-dose tutorial which is a tool that educators use to diagnose, teach, and assess targeted skills.  The key to the success of the AI tutorial is that it is programmed to use evidence-based practices (Fesler et al., 2026) …

Why Technical Readiness Is Not Enough: Institutional Barriers To Full Harvest Strategy Adoption In The International Pacific Halibut Commission, Evelyn Roozee, Owen Temby, Gordon M. Hickey

School of Earth, Environmental, & Marine Sciences Faculty Publications

Harvest strategies are increasingly promoted as a mechanism to reduce political discretion and align fisheries management with pre-agreed scientific objectives. While substantial progress has been made in tuna regional fisheries management organizations (RFMOs), non-tuna RFMOs have lagged behind. Existing research has focused primarily on technical modeling challenges, with comparatively limited attention to the governance dynamics shaping adoption. Using the International Pacific Halibut Commission (IPHC) as an instrumental case study, we examine the progress and delays in the development of a harvest strategy policy (HSP) through semi-structured interviews and participant observation. We find that the IPHC successfully addressed commonly cited barriers, …

Design And Synthesis Of Sulfonamide Derivatives For Antimicrobial, Antioxidant, And Antidiabetic Applications, Meriama Kufa Genamo

All Theses

The escalating burden of antimicrobial resistance (AMR), together with the increasing prevalence of oxidative stress-related disorders and diabetes mellitus, highlights the urgent need for multifunctional therapeutic agents capable of addressing multiple pathological pathways within a single molecular framework. In this study, three novel N-(4-substituted sulfonyl phenyl)-2-[4-(2-fluorophenyl) piperazin-1-yl] acetamide derivatives (4a-c) were rationally designed, synthesized, and investigated for their antimicrobial, antioxidant, and antidiabetic potential activities. The target compounds were synthesized through a multistep synthetic strategy involving sulfonamide formation, deprotection, chloroacetylation, and nucleophilic substitution reactions. Structural characterization was accomplished using 1H/13C NMR spectroscopy, confirming successful synthesis of the desired derivatives. Biological evaluation …

Effect Of Food Resource, Preservation Method, And Preservation Duration On Larval Size Of Forensically Important Fly Species (Order: Diptera), John Zukowski

Student Theses

Forensic entomology is a vital discipline that can aid in the proceedings of criminal cases. Larval age and development are important aspects to consider when utilizing blow flies (Family: Calliphoridae) for estimates pertaining to the initial time of colonization (TOC), which contributes to postmortem interval (PMI) estimations. Thus, it is important to understand the factors that influence larval size and development, since larval size is commonly used as a proxy for age. Larvae of three species of flies, Lucilia sericata (Meigen), Calliphora vicina (Robineau-Desvoidy), and Phormia regina (Meigen), were reared on five different food resources. Specimens of L. sericata and …

Viability Of Manually Passing Projectiles Through The Barrel Of A Firearm In Lieu Of Test Firing, Mara V. Mineo

Student Theses

Forensic examinations of discharged projectiles are made possible by the toolmarks and striations made by the barrel the projectiles pass through. Suspect barrels are attached to firearms and test fired to compare these toolmarks and striations with found evidence. However, physically damaged barrels could potentially be unable to produce exemplars. This study tests the viability of manually passing projectiles through stationary barrels as a meaningful and accurate means to produce acceptable exemplars that are able to be compared against recovered evidence. A total of 18 projectiles were manually passed between two distinct Glock handgun barrels and viewed under a comparison …

Interplay Of Atomicity, Polarization, And Quantization On Performance And Reliability In Gan Finfets, Salim I. Almenshad

Dissertations

GaN based nanoscale high-electron-mobility transistors (HEMTs) are the next generation of transistor technology that features the unique combination of higher power, wider bandwidth, low noise, higher efficiency, and temperature/radiation hardness than conventional AlGaAs and Si based technologies. However, enhancement mode operation for nanoscale channel region is the most recent needed area of research. As well as reliability of these devices remains a major concern. The main objective of this proposed research is to numerically investigate the role of atomistic inhomogeneity and quantization in low-dimensionality lateral tri-gated AlGaN/GaN FinFET devices. It is shown that 3-D configured AlGaN/GaN FinFETs with narrow enough …

Quaking Aspen On Cedar Mountain, Utah: Status And Update, Jaycee Cappaert, Larissa L. Yocom, Paul C. Rogers, Darren J. Mcavoy, R. Justin Derose

Wildland Resources Student Research

Quaking aspen forests are important communities in the western United States where they provide preferential food and habitat for animals, limit wildfires from spreading, and have favorable aesthetics, among other things. Their putative decline is an issue for ecology and management. We remeasured the aspen population on Cedar Mountain, Utah, to assess changes to its condition since it was originally measured in 2008 and laid the groundwork for continued aspen monitoring on Cedar Mountain. Our objectives were to compare current metrics of stand structure and composition, mortality, crown dieback, bole damage, regeneration, and recruitment, to those of the original inventory. …

From Understanding To Production: A Qualitative Case Study Of Instructional Alignment And Bar Examination Readiness At One Law School, Mackenzie E. Gray

Education (PhD) Dissertations

Many law students who understand the law struggle to produce it under examination conditions.This qualitative case study examined how instruction in three settings at one ABA-accredited law school (first-year doctrinal, upper-division doctrinal, and for-credit bar preparation courses) shaped students’ perceptions of their readiness for the California Bar Examination. Grounded in metacognitive transfer theory, the study drew on 18 classroom observations across six courses, semi-structured interviews with seven students and four professors, and a simulated bar examination scored against a criterion-referenced rubric, all collected during the Spring 2026 semester. Interview data were analyzed through codebook thematic analysis. Five themes resulted. Students …

Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapies, Yujia Wang

Dissertations and Theses (Open Access)

Adoptive cell therapies (ACT) have shown promising progress in combating cancer, but clinical responses remain heterogeneous. Key determinants, including the functional states of infused cells, tumor–immune interactions, and dosing strategies, are difficult to resolve experimentally in the dynamic and heterogeneous tumor microenvironment, limiting optimization of ACT products and treatment regimens. To address the gap, we developed ABMACT (Agent-Based Model for Adoptive Cell Therapies), a computational framework that reconstruct key cellular functions, interactions, and molecular signatures to recapitulate cell population dynamics associated with differential treatment responses. ABMACT encodes autonomous “virtual cells” using literature-informed rules calibrated with experimental data, enabling simulation of …

Transcriptional Regulation In The Uterine Luminal Epithelium, Evelyn A. Carrion

Dissertations and Theses (Open Access)

Transcriptional Regulation in the Uterine Luminal Epithelium

Evelyn A. Carrion

Advisor: Richard R. Behringer, PhD

Abstract

The uterus is an organ comprised of multiple tissues that are essential for women’s health and reproduction. The uterus is composed of multiple tissue layers, including the perimetrium, myometrium, and the endometrium. The endometrium is the inner lining of the uterus, and contains the luminal epithelium, glandular epithelium, and stroma. The luminal epithelium is a simple columnar layer of cells that is necessary for embryo implantation. The uterus is derived in part from the embryonic precursor tissue called the Müllerian duct. There are no …

Ai-Driven Segmentation And Volumetric Response Modeling Of Liver Regions To Radiotherapy, Aashish Chandra Gupta

Dissertations and Theses (Open Access)

In liver-directed radiotherapy (RT), liver regions receiving higher doses typically undergo atrophy while contralateral/adjacent lower-dose regions may exhibit compensatory hypertrophy through regeneration of healthy tissue. Optimizing the RT plan to promote regional hypertrophy while minimizing the risk of developing atrophy has the potential to enhance post-RT liver function and long-term survivorship. However, current clinical practice largely relies on global liver dose-volume metrics during RT-planning, which may obscure favorable dose-response correlation and limit actionable guidance for clinicians. Therefore, we hypothesized that post-RT regional liver response is governed by a combination of region-specific dose-volume and patient clinical features, and that these responses …

Defining The Role Of Spxa1 And Spxa2 In Group A Streptococcus (Gas), Gretchen Anne Morrison

Dissertations and Theses (Open Access)

Group A Streptococcus (GAS) is a human-restricted pathogen whose global incidence has surged in the post-COVID era. The ability of GAS to shift from a colonizing to invasive phenotype depends on coordinated virulence gene regulation in response to host-imposed stressors. The paralogous global transcriptional regulators, SpxA1 and SpxA2, have emerged as central mediators of these adaptive responses; however, the mechanisms by which these regulators influence both global gene regulation in direct response to external stresses and the host response as a result of regulatory changes remain incompletely understood. Using an integrated multi-omic approach, we define the distinct yet interconnected regulatory …

Regulation Of Müllerian Duct Mesenchyme Transcription During Mammalian Sex Differentiation, Haowen Li, Richard R Behringer, Rachel D Mullen

Dissertations and Theses (Open Access)

Sp7/Osterix (Osx) encodes a zinc-finger transcription factor of the Specificity-protein family discovered by Nakashima et al. at the MD Anderson Cancer Center. While primarily recognized for its role in osteogenesis, Osx has also been implicated in mammalian reproductive development, particularly in male sex differentiation, where Müllerian Duct (MD) regression occurs, mediated by anti-Müllerian hormone (AMH) signaling. AMH-induced regression signals are transduced by the mesenchymal tissue surrounding the ductal structure, known as the Müllerian Duct mesenchyme (MDM). It was discovered that AMH signaling is necessary and sufficient for driving Osx expression in MDM. A previous transgenic mouse reporter …

Oxidative Stress Mediated Glutamate Release And Nmda Receptor-Dependent Synaptic Remodeling In Radiation-Induced Cognitive Dysfunction, Thanh Lam

Dissertations and Theses (Open Access)

In children younger than 14 years old, the brain and other parts of the central nervous system are the most common sites for solid tumors. Radiotherapy is an effective treatment for central nervous system (CNS) tumors. However, it often causes a progressive decline in cognitive functions, which is especially devastating for pediatric patients. Although post-mitotic neurons are generally considered resistant to radiation-induced immediate cell death, ionizing radiation causes complex neurochemical and structural changes that damage synaptic integrity. In this study, we examined the molecular cascades following a 10 Gy radiation dose applied to mouse cortical neurons. We found that radiation-induced …

Mutational Analysis Of Domain Functions In The Yeast Decapping Enzyme Dcp2, Jellisa Ewan, Ambro Van Hoof

Dissertations and Theses (Open Access)

In yeast, the major mRNA decay pathway involves deadenylation of the 3’ poly-A tail, followed by decapping of the 5’ m7Gppp cap and subsequent 5’ to 3’ degradation or 3’ to 5’ degradation. This is carried out by Pan2/Pan3 and Ccr4/Not deadenylases, the decapping enzyme Dcp2, and Xrn1 and  RNA exosome exoribonucleases, respectively. The eukaryotic mRNA decapping enzyme complex, Dcp1/Dcp2, is essential in yeast, and deletion of either gene is lethal. However, the deadenylases that act upstream and the 5’ exoribonuclease that act downstream of the decapping step are not, even though they are all highly conserved with no known …

From Geometry To Recognition: A Quantitative Framework For Tcr-Pmhc Structural Analysis In The Age Of Predicted Structures, Kun Hee Kim

Dissertations and Theses (Open Access)

Recognition of antigen by a T cell begins with a single physical event, the engagement of the T cell receptor (TCR) with a peptide-major histocompatibility complex (pMHC), and this interaction is encoded in the geometry with which the receptor docks onto the composite pMHC surface. Whether that docking geometry is biologically organized, and whether the structures now produced at scale by prediction preserve recognition or only reproduce that organization, are the two questions this thesis addresses. Two gaps stand in the way. The first is a gap of measurement, because docking geometry has never been made quantitatively comparable across many …

Antigen Discovery In Multiple Myeloma Using Integrated Long-Read Transcriptomics And Immunopeptidomics, Aya Albittar

Dissertations and Theses (Open Access)

Multiple myeloma (MM) remains an incurable plasma cell malignancy, with relapse driven by persistent chemotherapy-resistant cells and residual disease following treatment. Although immunotherapies have transformed MM care, their success depends on identifying tumor-specific antigens that can be safely targeted. While aberrant genomic structural variation and transcriptional dysregulation are increasingly recognized as sources of novel antigens in MM, the HLA-presented antigenic landscape of MM remains incompletely characterized, particularly for non-canonical, structurally-derived peptides, and long-read transcriptome-informed immunopeptidomic data specific to MM remain scarce.

We established an integrated antigen discovery platform combining long-read RNA sequencing (Iso-Seq) with mass spectrometry-based HLA immunoprecipitation and immunopeptidomics …

The Correlation Between Frequency Of School Lunch Consumption And Bmi Percentile, Brayden Rowland

Posters

No abstract provided.

Developing A Deep-Learning Model To Segment White Matter Lesions In Cerebral Palsy, Varsha Kumar, Hyukjin Yun, Rose N. Gelineau-Morel, Avner Meoded

Posters

No abstract provided.

Rural Emergency Department Perspectives On Telemedicine Consultation For Pediatric Emergencies, Caroline Nemechek, Kimberly Randell, Romina Barral, Michelle K. Arzubi-Hughes

Posters

No abstract provided.

Piloting Research In Action: To Act Or Not To Act?, Kosi Okuagu, Lauren Yan, Emily A. Hurley

Posters

No abstract provided.

“We’Re Just Always There For Each Other”: Examining Social Support For African American Caregivers Of Oncology Patients, Madeleine Lee, Keisha White Makinde

Posters

No abstract provided.

Investigating Postbiotic-Derived Therapies For Necrotizing Enterocolitis In Infants, Ilan Reichbart, Marianne N. Nsumu, Joshua Wheatley, Susana Chavez-Bueno, Alain Cuna

Posters

No abstract provided.

Evaluating The Relationship Between Naltrexone Systemic Exposure And Acute Brain Response Using A Neuroimaging-Based Pharmacodynamic Biomarker, Trisha Rastogi, Stephani Stancil, Susan M. Abdel-Rahman, Michael Bartkoski, James Bartolotti, Mariah E. Brewe, William Brooks, Morgan Brucks, Anna Burns, Ann M. Davis, Laura Martin, Jeffrey R. Strawn, John Tumberger, Michaela Voss, Hung-Wen Yeh

Posters

No abstract provided.

Operationalizing Frailty: A Comparison Of Measurement Frameworks, Audrey P. Doege, Madeline Donnelli, Daniel Forsha, Thomas Cochran, William R. Black, David A. White

Posters

No abstract provided.

Exploring The Impacts Of Research Including Zealous Genz-Ers (Rizz), Afraah Hawa, Andrea Bradley-Ewing Mpa, Ma, Kimberly A. Randell, Md, Msc, Yesenia Montoya, Karynn E. Glover

Posters

No abstract provided.

Endotyping Obstructive Sleep Apnea In Infants With Micrognathia, Alexis Dominic, Zarmina Ehsan, Baha Al-Shawwa Md, Karishma Rao, Blake A. Welker, Meghan Tracy, Andrew Li, Alessandra Manoylova-Vedder, Shiyuan Chen, Shu-Ching Chen, Members Of The Data Science And Analytics Innovation Center (Dsaic), John P. Dahl, Janelle Noel-Macdonnell

Posters

No abstract provided.