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Articles 202741 - 202770 of 5164609
Full-Text Articles in Entire DC Network
A Qualitative Inquiry Of Exercise Preferences Among Hispanic Adults With Multiple Sclerosis, Stephanie L Silveira, Robert W Motl, Tania Ontiveros, Victoria Flores
A Qualitative Inquiry Of Exercise Preferences Among Hispanic Adults With Multiple Sclerosis, Stephanie L Silveira, Robert W Motl, Tania Ontiveros, Victoria Flores
Faculty, Staff and Student Publications
This study aimed to identify the components of an ideal exercise training program for Hispanics with multiple sclerosis (MS), cultural adaptations, and avenues for dissemination of information to this population. Online, semi-structured interviews were conducted with 27 adults with MS who identified as Hispanic. A deductive content analysis approach was applied for assessing necessary and desired components of an exercise program. Participants articulated preferences for "what," "when," "where," and "who" of exercise programs. All participants expressed an interest in aerobic training (n = 27) and need for resistance (n = 14), flexibility (n = 8), and neuromotor components (n = …
Using The Healthy Native Youth Implementation Toolbox To Provide Web-Based Adolescent Health Promotion Decision Support To American Indian And Alaska Native Communities: Implementation Study, Amrita Sidhu, Ross Shegog, Stephanie Craig-Rushing, Nicole Trevino, Michelle Singer, Cornelia Jessen, Gwenda Gorman, Sean Simpson, Melissa Peskin, Belinda Hernandez, Christine Markham
Using The Healthy Native Youth Implementation Toolbox To Provide Web-Based Adolescent Health Promotion Decision Support To American Indian And Alaska Native Communities: Implementation Study, Amrita Sidhu, Ross Shegog, Stephanie Craig-Rushing, Nicole Trevino, Michelle Singer, Cornelia Jessen, Gwenda Gorman, Sean Simpson, Melissa Peskin, Belinda Hernandez, Christine Markham
Faculty, Staff and Student Publications
Background: American Indian and Alaska Native (AI/AN) youth experience numerous health inequities, including those in sexual, reproductive, and mental health. Implementation of culturally relevant, age-appropriate evidence-based programs may mitigate these inequities. However, numerous barriers limit the adoption and implementation of evidence-based adolescent health promotion programs in AI/AN communities.
Objective: This study examines user reach and engagement from 2022 to 2024 of web-based decision support (the Healthy Native Youth [HNY] website and the embedded HNY Implementation Toolbox), designed to increase the implementation of evidence-based adolescent health promotion programming in AI/AN communities.
Methods: Promotional strategies were designed for optimal geographic reach to …
Nursing Educators’ Perceptions Of Using Virtual Simulated Games In Nursing Education, Ruhee Waheeda Mir
Nursing Educators’ Perceptions Of Using Virtual Simulated Games In Nursing Education, Ruhee Waheeda Mir
Walden Dissertations and Doctoral Studies
Nursing educators of Trinidad and Tobago have limited experience with virtual simulated games (VSGs) as a part of their teaching methodology. This lack of experience was highlighted during the COVID-19 pandemic as educators had to use virtual approaches in their classrooms and struggled with unfamiliar technologies. The purpose of this qualitative descriptive study, guided by the extended technology acceptance model, was to explore the perceptions of Trinidadian and Tobagonian nursing educators regarding the use of a VSG as a teaching tool. The sample consisted of eight nursing educators from an educational institute in Trinidad who met the criteria of being …
Relationship Between Department Of Justice Consent Decrees And Police Use Of Force And Search And Seizure Incidents, Judith Crowell
Relationship Between Department Of Justice Consent Decrees And Police Use Of Force And Search And Seizure Incidents, Judith Crowell
Walden Dissertations and Doctoral Studies
Efforts to reform law enforcement practices related to use of force and search and seizure incidents have largely involved policy revisions and training enhancements. This study compares use of force and search and seizure incidents in the Baltimore City (BCPD) and the Chicago (CPD) Police Departments before and after the implementation of a Department of Justice (DOJ) Consent Decree. An Independent Samples t-test was used to analyze whether there was a statistically significant difference between pre and post use of force incidents and search and seizure incidents by the BCPD and the CPD. Secondary data regarding the BCPD use of …
Spectrum, Volume 54, Issue 11, Sacred Heart University
Spectrum, Volume 54, Issue 11, Sacred Heart University
Newspapers (Obelisk & Spectrum)
Highlights include: FSL Hosts NFL Greek Week - From Chatbots to Classrooms: SHU’s New AI Minor - Phi Alpha Theta Honor Society Induction - Sacred Heart’s Club For Hope - Honoring Audrey Niblo - Women’s Track Running Through Records (Again!) - Pioneers Pursue Playoffs
2025-04-16 Mariners Baseball Is Back!, Diego Dumlao
2025-04-16 Mariners Baseball Is Back!, Diego Dumlao
The Spectator Online
No abstract provided.
Knowledge Distillation For Efficient Object Detection: Toward Scalable And Deployable Vision Models, Qizhen Lan
Knowledge Distillation For Efficient Object Detection: Toward Scalable And Deployable Vision Models, Qizhen Lan
All ETDs from UAB
Object detection is a critical component of autonomous driving, requiring real-time, robust perception to ensure safety. However, state-of-the-art deep neural network object detectors typically incur high computational cost and memory footprint, hindering their deployment in resource-constrained environments such as self-driving vehicles. This dissertation addresses the need for efficient yet accurate detectors by leveraging knowledge distillation (KD), a model compression technique that transfers knowledge from a high-capacity teacher model to a lightweight student model. While KD has seen success in image classification, its application to object detection poses unique challenges due to multiple instances per image and complex output structures. To …
Losac Minutes 2025-04-16, Library Operating Staff Advisory Committee
Losac Minutes 2025-04-16, Library Operating Staff Advisory Committee
University Libraries Archives
No abstract provided.
Spartan Daily, April 16, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, April 16, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2025
Volume 164, Issue 33
Short- And Long-Term Effects Of Early Versus Delayed Treatment With Ocrelizumab On Cerebellar Volume Loss In Patients With Rms And Ppms, Douglas L Arnold, Shannon Kolind, Haz-Edine Assemlal, Amit Bar-Or, Matilde Inglese, Ludwig Kappos, Katrin Parmar, Till Sprenger, Anthony Traboulsee, Irene M Vavasour, Jerry S Wolinsky, Corrado Bernasconi, Ulrike Bonati, Stefano Magon, Björn Tackenberg, Laura Gaetano
Short- And Long-Term Effects Of Early Versus Delayed Treatment With Ocrelizumab On Cerebellar Volume Loss In Patients With Rms And Ppms, Douglas L Arnold, Shannon Kolind, Haz-Edine Assemlal, Amit Bar-Or, Matilde Inglese, Ludwig Kappos, Katrin Parmar, Till Sprenger, Anthony Traboulsee, Irene M Vavasour, Jerry S Wolinsky, Corrado Bernasconi, Ulrike Bonati, Stefano Magon, Björn Tackenberg, Laura Gaetano
Faculty, Staff and Student Publications
Background: The cerebellum is a functionally and anatomically complex structure, which, in multiple sclerosis (MS), is affected by focal white/gray matter lesions and by secondary neurodegeneration of afferent/efferent connections to the supratentorial brain and the spinal cord.
Objectives: To assess the efficacy of ocrelizumab compared with interferon β-1a (IFN β-1a)/placebo on cerebellar volume loss and the effect of switching to ocrelizumab on volume change in the Phase III trials in relapsing MS (RMS, OPERA I/II) and in primary progressive MS (PPMS, ORATORIO).
Methods: Cerebellar volume change was computed using paired Jacobian integration and analyzed using a mixed-effect repeated measurement model. …
We Speak Life Into Their Language: Black Educators’ Approaches To Linguistic Justice In Urban Secondary Ela Classrooms, Lakeisha A. Davis
We Speak Life Into Their Language: Black Educators’ Approaches To Linguistic Justice In Urban Secondary Ela Classrooms, Lakeisha A. Davis
Dissertations
This study explores how Black educators navigate linguistic justice, deficit thinking, and stereotypes in urban secondary English Language Arts (ELA) classrooms. Using a hermeneutic phenomenological approach, it examines how teachers affirm Black Language (BL) while balancing the demands of White Mainstream English (WME) in academic spaces. Findings reveal that although educators employ culturally affirming strategies, they face challenges from restrictive language policies and standardized assessments. To counteract these barriers, they adopt negotiation practices that support students’ linguistic and cultural identities. From these findings, the study proposes Dynamic Linguistic Uplift (DLU)—a new theoretical framework that illustrates how Black educators sustain BL …
Deep Learning-Based Automatic Segmentation Of Cerebral Infarcts On Diffusion Mri, Wi-Sun Ryu, Dawid Schellingerhout, Jonghyeok Park, Jinyong Chung, Sang-Wuk Jeong, Dong-Seok Gwak, Beom Joon Kim, Joon-Tae Kim, Keun-Sik Hong, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Man Seok Park, Dongmin Kim, Oh Young Bang, Eung Yeop Kim, Chul-Ho Sohn, Hosung Kim, Hee-Joon Bae, Dong-Eog Kim
Deep Learning-Based Automatic Segmentation Of Cerebral Infarcts On Diffusion Mri, Wi-Sun Ryu, Dawid Schellingerhout, Jonghyeok Park, Jinyong Chung, Sang-Wuk Jeong, Dong-Seok Gwak, Beom Joon Kim, Joon-Tae Kim, Keun-Sik Hong, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Man Seok Park, Dongmin Kim, Oh Young Bang, Eung Yeop Kim, Chul-Ho Sohn, Hosung Kim, Hee-Joon Bae, Dong-Eog Kim
Faculty, Staff and Student Publications
We explored effects of (1) training with various sample sizes of multi-site vs. single-site training data, (2) cross-site domain adaptation, and (3) data sources and features on the performance of algorithms segmenting cerebral infarcts on Magnetic Resonance Imaging (MRI). We used 10,820 annotated diffusion-weighted images (DWIs) from 10 university hospitals. Algorithms based on 3D U-net were trained using progressively larger subsamples (ranging from 217 to 8661), while internal testing employed a distinct set of 2159 DWIs. External validation was conducted using three unrelated datasets (n = 2777, 50, and 250). For domain adaptation, we utilized 50 to 1000 subsamples from …
Models And Mechanisms Of Chemotherapy-Induced Side Effects, Junwei Du
Models And Mechanisms Of Chemotherapy-Induced Side Effects, Junwei Du
McKelvey School of Engineering Graduate Student Theses & Dissertations
Cancer is among the leading causes of death worldwide. Chemotherapy remains a cornerstone in the treatment of various cancers; however, it often leads to a range of debilitating side effects that compromise its efficacy and profoundly impact patients' quality of life and psychosocial well-being. These side effects can be broadly categorized into short-term effects, such as nausea, vomiting, fatigue, hair loss, and neutropenia, and long-term effects which can persist months or even years after treatment, including peripheral neuropathies, cognitive impairment, cardiotoxicity, nephrotoxicity and ototoxicity. Among the most common and dose-limiting side effects are chemotherapy-induced peripheral neuropathy (CIPN) and cardiotoxicity (CTX). …
Cystic Fibrosis-Related Neurodegenerative Disease Associated With Tauopathy And Cognitive Decline In Aged Cf Mice, Danica F. Patton-Parfyonov, Xinming Wang, Sarah Barker, Deborah A. Corey, Edwin Vázquez-Rosa, Nichele Abeyesundere, Whitney M. Ward, Rebecca Darrah, Jung A. Woo, David E. Kang, Andrew A. Pieper, Thomas J. Kelley
Cystic Fibrosis-Related Neurodegenerative Disease Associated With Tauopathy And Cognitive Decline In Aged Cf Mice, Danica F. Patton-Parfyonov, Xinming Wang, Sarah Barker, Deborah A. Corey, Edwin Vázquez-Rosa, Nichele Abeyesundere, Whitney M. Ward, Rebecca Darrah, Jung A. Woo, David E. Kang, Andrew A. Pieper, Thomas J. Kelley
Faculty Scholarship
Background: Highly effective modulator therapies (HEMT) are increasing the lifespan for many people with cystic fibrosis (pwCF), making it necessary to identify and understand CF specific age-related consequences. In this study, we examine the impact of aging on cognitive function and age-related brain pathology in a CF mouse model focusing on phospho-Tau (pTau) pathology. Methods: Cognitive function was measured by novel object recognition and spontaneous alternation behavior tests. Hippocampal neuronal function was assessed by measuring long-term potentiation (LTP) electrophysiology, the synaptic correlate of learning and memory. Tau pathology was assessed by immunohistochemical analyses and western blot assessment of pTau levels …
Percutaneous Retrieval Of Free-Floating Amulet Device From Left Atrium, Elliott Elias, Ramon Quesada, Nish Patel
Percutaneous Retrieval Of Free-Floating Amulet Device From Left Atrium, Elliott Elias, Ramon Quesada, Nish Patel
All Publications
Atrial fibrillation (AF) is a common cardiac arrhythmia, significantly increasing the risk of thromboembolic events, particularly cerebral vascular accidents. Left atrial appendage occluder devices have been introduced as an alternative to anticoagulation therapy for stroke prevention in AF patients, but their use can be complicated by device embolization. This report details the case of an 81-year-old woman with persistent AF, chronic immune thrombocytopenic purpura, and various other comorbidities, who underwent a left atrial appendage closure using an Amulet device. Despite the successful initial placement, a subsequent transthoracic echocardiogram revealed device embolization within the left atrium. A percutaneous retrieval was successfully …
Midweek Memo, Georgia Southern University
Midweek Memo, Georgia Southern University
Midweek Memo
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Ligo Detector Characterization In The First Half Of The Fourth Observing Run, S. Soni, B. K. Berger, D. Davis, F. Di Renzo, A. Effler, T. Ferreira, E. Goetz, Francisco Llamas Villarreal, Volker Quetschke, J. Glanzer
Ligo Detector Characterization In The First Half Of The Fourth Observing Run, S. Soni, B. K. Berger, D. Davis, F. Di Renzo, A. Effler, T. Ferreira, E. Goetz, Francisco Llamas Villarreal, Volker Quetschke, J. Glanzer
Physics & Astronomy Faculty Publications
Progress in gravitational-wave (GW) astronomy depends upon having sensitive detectors with good data quality. Since the end of the Laser Interferometer Gravitational-Wave Observatory-Virgo-KAGRA third Observing run in March 2020, detector-characterization efforts have lead to increased sensitivity of the detectors, swifter validation of GW candidates and improved tools used for data-quality products. In this article, we discuss these efforts in detail and their impact on our ability to detect and study GWs. These include the multiple instrumental investigations that led to reduction in transient noise, along with the work to improve software tools used to examine the detectors data-quality. We end …
Avian Detection Data And Environmental Covariates For Utah, Usa Over The Years 2017-2021, Amanda L. Hayes-Puttfarcken
Avian Detection Data And Environmental Covariates For Utah, Usa Over The Years 2017-2021, Amanda L. Hayes-Puttfarcken
Browse all Datasets
Integrated Monitoring in Bird Conservation Regions (IMBCR) detection data for the state of Utah, USA, and LANDFIRE uncharacteristic exotic Departure Score data over Utah during our study period, as well as additional environmental covariates used to make the model more ecologically accurate. Environmental covariates include average May precipitation, average June temperature, distance to the nearest road, percent canopy cover, and the percent of three habitat types as defined by LANDFIRE; open tree canopy, herbaceous, and shrubland.
Prenatal Exercise: The Importance Of Patient-Provider Communication, Stephanie Patton
Prenatal Exercise: The Importance Of Patient-Provider Communication, Stephanie Patton
Doctorate in Kinesiology
There is a low adherence to prenatal exercise guidelines which may be affected by several barriers including a lack of knowledge regarding the benefits to, safety of, and general guidelines for prenatal exercise. This study sought to investigate the communication that occurs in prenatal appointments and the barriers associated with low exercise rates. Data was collected from 54 pregnant and postpartum women between the ages of 18-40 through an anonymous survey and analyzed through SPSS software. Twenty-four (44.4%) respondents indicated discussion regarding exercise recommendations occurred and five (9.3%) shared that resources for exercise recommendations were provided. Twenty-three (42.6%) participants were …
Exploring The Acute Effects Of Sedentary Behaviors On Cardiometabolic Risk In Hispanic Adolescents With Obesity: A Randomized Crossover Study, Erica G Soltero, Osamah Salim, Yiming Mirabile, Salma M Musaad
Exploring The Acute Effects Of Sedentary Behaviors On Cardiometabolic Risk In Hispanic Adolescents With Obesity: A Randomized Crossover Study, Erica G Soltero, Osamah Salim, Yiming Mirabile, Salma M Musaad
Children’s Nutrition Research Center Staff Publications
Background/Objectives: Time spent in sedentary pursuits is associated with adverse metabolic profiles. Adolescents spend 65-75% of their day in sedentary pursuits; however, evidence among youth is less conclusive. This study examined the effects of an acute 4 h bout of sedentary behaviors on cardiometabolic outcomes and energy expenditure in Hispanic adolescents (12-16 years old) with obesity (BMI% ≥ 95th).
Methods: This study used a randomized cross-over design to engage participants (N = 12) in two sedentary conditions, an active condition where youth were engaged in two hours of 'active' sitting activities (e.g., reading and puzzles) and two hours …
Developing An Online Community Advisory Board (Cab) Of Parents From Social Media To Co-Design An Human Papillomavirus Vaccine Intervention: Participatory Research Study, Regan M. Murray, Shawn C. Chiang, Ann C. Klassen, Jennifer A. Manganello, Amy E. Leader, Wen-Juo Lo, Philip M. Massey
Developing An Online Community Advisory Board (Cab) Of Parents From Social Media To Co-Design An Human Papillomavirus Vaccine Intervention: Participatory Research Study, Regan M. Murray, Shawn C. Chiang, Ann C. Klassen, Jennifer A. Manganello, Amy E. Leader, Wen-Juo Lo, Philip M. Massey
Department of Medical Oncology Faculty Papers
BACKGROUND: Social media health interventions have grown significantly in recent years. However, researchers are still developing innovative methods to meaningfully engage online communities to inform research activities. Little has been documented describing this approach of using online community advisory boards (CABs) to co-create health communication interventions on social media.
OBJECTIVE: This study describes the formation, engagement, and maintenance of an online CAB focused on co-creating a health education intervention for parents regarding the human papillomavirus (HPV) vaccine. The study provides guiding principles for public health researchers implementing such CABs in future digital health interventions.
METHODS: In May 2020, Twitter was …
All Roads That Lead To The Myocardium: Assessment Of Anomalies Of Coronary Artery Course, Ibrahim Khayyat, Silvana Molossi, Ada C Stefanescu Schmidt
All Roads That Lead To The Myocardium: Assessment Of Anomalies Of Coronary Artery Course, Ibrahim Khayyat, Silvana Molossi, Ada C Stefanescu Schmidt
Faculty, Staff and Students Publications
No abstract provided.
New Era Of Entrepreneurship Begins At Iwu With The Petrick Idea Center Groundbreaking, Julia Perez
New Era Of Entrepreneurship Begins At Iwu With The Petrick Idea Center Groundbreaking, Julia Perez
Press Releases 2020-2029
No abstract provided.
Imaging Peripheral Nerves In Vivo With Ct Neurogram Using Novel 2,4,6-Tri-Iodinated Lidocaine Contrast Agent, Rui Tang, Ron Perez, David M Brogan, Mikhail Y Berezin, James E Mccarthy
Imaging Peripheral Nerves In Vivo With Ct Neurogram Using Novel 2,4,6-Tri-Iodinated Lidocaine Contrast Agent, Rui Tang, Ron Perez, David M Brogan, Mikhail Y Berezin, James E Mccarthy
2020-Current year OA Pubs
Peripheral nerve injuries are a significant concern in surgical procedures, often leading to chronic pain and functional impairment. Despite advancements in imaging, preoperative and intraoperative visualization of peripheral nerves remains a challenge. This study introduces and evaluates a novel tri-iodinated lidocaine-based contrast agent for computed tomography neurography, aiming to enhance the intraoperative visibility of peripheral nerves in vivo. A tri-iodinated lidocaine analogue was synthesized and characterized for its radiodensity, sodium channel binding and nerve affinity. Sodium channel affinity was performed using molecular docking. In vitro contrast enhancement was assessed by comparing the agent's Hounsfield unit (HU) values with those of …
Elevated Mitochondrial Membrane Potential Is A Therapeutic Vulnerability In Dnmt3a-Mutant Clonal Hematopoiesis, Kira A Young, Grant A Challen, Et Al.
Elevated Mitochondrial Membrane Potential Is A Therapeutic Vulnerability In Dnmt3a-Mutant Clonal Hematopoiesis, Kira A Young, Grant A Challen, Et Al.
2020-Current year OA Pubs
The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how CH-mutant cells gain a selective advantage in these contexts is an unresolved question. Using a murine model of CH (Dnmt3a
The Kemp Foundation’S Teaching Excellence Award Ceremony (2025 Program And Video), Illinois Wesleyan University
The Kemp Foundation’S Teaching Excellence Award Ceremony (2025 Program And Video), Illinois Wesleyan University
The Kemp Foundation's Teaching Excellence Award Ceremony Programs
No abstract provided.
A Qualitative Investigation Of Middle School And High School Students' Perspectives On Their Cultural Identities, Jasmine Blake
A Qualitative Investigation Of Middle School And High School Students' Perspectives On Their Cultural Identities, Jasmine Blake
Electronic Theses and Dissertations Archive
Adolescence is a critical period for identity development. Previous research highlights the challenges related to having an unclear conception of one’s identity. Importantly, qualitative research on using student voice and student perspectives of their cultural identities to improve overall school climate and teacher-student relationships has been overlooked. To improve culturally responsive practices, researchers should account for the voices of primary stakeholders that may be missed in quantitative research methods. Thus, the current study aims to use qualitative interviews of middle and high school students to use student voice to improve culturally responsive practices and further our understanding of cultural humility. …
A Daily Diary Study To Investigate Self-Compassion And Loneliness: Implications For Students And Connection, Elizabeth S. Wells
A Daily Diary Study To Investigate Self-Compassion And Loneliness: Implications For Students And Connection, Elizabeth S. Wells
Electronic Theses and Dissertations Archive
Understanding self-compassion is essential for psychologists seeking to address mental health concerns, particularly among students and young adults. Loneliness, which refers to the perceived quality rather than the quantity of relationships, has a significant impact on the well-being and social connections of adolescents and young adults (Bluth et al., 2017; Holt-Lunstad, 2017; Office of the Surgeon General, 2023, May; Taylor et al., 2023). Daily self-compassion practices may help alleviate loneliness, foster a sense of belonging, reduce feelings of exclusion, and improve individual well-being and overall school climate (Baker & McNulty, 2011; Bluth et al., 2022; Liu et al., 2020; Neff, …
The Impact Of Antidepressant Uses On Community-Dwelling Older Adults In The Us, Easter Protiva Gain
The Impact Of Antidepressant Uses On Community-Dwelling Older Adults In The Us, Easter Protiva Gain
Electronic Theses and Dissertations Archive
Mental health is a vital component of the overall well-being across the lifespan and is the third leading cause of disability globally. One in seven US adults aged 65 or older reported some anxiety and/or depression symptoms, but one in four older adults use some antidepressants and the prescriptions were steadily increasing. This study investigated the impact of antidepressant uses focusing on discontinuation of antidepressants and the risk of medication resumption, inconsistency of antidepressant prescription, and increased healthcare uses by self-reported anxiety and depression symptoms among community-dwelling older adults in the US. Our study conducted a longitudinal study using Medicare …
Exploring Potential Barriers To The Fragile X Syndrome Cascade Screening Process, Austin Corsmeier
Exploring Potential Barriers To The Fragile X Syndrome Cascade Screening Process, Austin Corsmeier
Electronic Theses and Dissertations Archive
Cascade screening, the systematic process of performing genetic screening in at-risk blood relatives of individuals who have been identified with specific genetic mutations, is vital to ensure that Fragile X Syndrome (FXS) is identified and diagnosed accurately and that early intervention services are provided to support the clinical symptoms associated with FXS. Cascade screening leads to identification of both male and female premutation carriers and those with full mutation FXS leading to early diagnosis, prompt treatment and awareness of potential medical, psychosocial, and/or neurodevelopmental issues, and improvement in the affected individual’s quality of life. Despite the clear clinical benefits of …