Digital Commons Network^™

Preservation And Integrity Of Laboratory Solutions: Understanding The Impact Of Storage Practices On Chemical Stability And Experimental Accuracy, Azza Al Jahdhami

Honors Theses

Chemical storage methods represent a key matter ignored within labs, educational sites, workplaces, and even households. Many people, including various students and instructors within the chemistry field, are unaware of the proper methods for storing and disposing of common chemicals. This study aims to understand the effects of storage practices on chemical stability and experimental accuracy, dealing with the following questions: What kind of effects result from improper chemical disposal? How can improper storage affect the overall chemical effectiveness? Why is sink disposal of many solutions discouraged, and why is waste container disposal always necessary?

Through a literature review, this …

Evaluating The Potential For Reusing Process Waste Fiber, Elisha Ewing

Honors Theses

This study was born out of curiosity around the potential use of reject materials from the papermaking screening system for molded fiber product development. The team sought to explore the technical feasibility of this concept and develop a proposed design for mill implementation. The project supports the common papermaking objective of reducing fiber loss from the stock preparation process.

The project assessed first the technical feasibility through laboratory testing and trials. The team dedicated time to characterizing screen reject samples from local mills and running trials using the good fibers extracted from the samples. Molded fiber products were successfully created …

Nanostructured Transition Metal Oxides For Electrochemical Co2 And Methane Conversion, Olumide O. Oladoyin

Chemical and Biological Engineering ETDs

Rising atmospheric CO₂ and CH₄ drive climate change, prompting research into their electrochemical conversion to valuable products. This study investigates electrodeposited nanostructured transition metal oxides (TMOs), unary (CuO, Co₃O₄) and dual (Cu-Co oxide) as catalysts for CO₂ reduction and CH₄ oxidation under ambient conditions. Fabricated on various substrates (Cu foil, SS316, carbon paper) and characterized by SEM, their electrochemical performance was evaluated via cyclic voltammetry.

Cu-Co oxide showed superior CO₂ reduction, leveraging the strengths of individual oxides. Co₃O₄ exhibited higher current densities for CH₄ oxidation, with SS316 proving the best substrate. Catalyst composition, morphology, and substrate significantly influenced efficiency. While …

Evolution Of The Tumor Immune Landscape During Treatment With Tebentafusp, A T Cell Receptor-Cd3 Bispecific, Joseph Sacco, Peter Kirk, Emma Leach, Alexander Shoushtari, Richard Carvajal, Camille Britton-Rivet, Sophie Khakoo, Laura Collins, Luis De La Cruz-Merino, Zeynep Eroglu, Alexandra Ikeguchi, Paul Nathan, Omid Hamid, Marcus Butler, Sarah Stanhope, Koustubh Ranade, Takami Sato

Department of Medical Oncology Faculty Papers

Metastatic uveal melanoma is an aggressive disease with poor outcome, which is refractory to immune checkpoint inhibitors. A T cell receptor (TCR)-based CD3 bispecific, tebentafusp, delivers clinical benefit in patients with metastatic uveal melanoma. Understanding the molecular basis for the anti-tumor activity of tebentafusp in an indication where checkpoint inhibitors are ineffective could aid in identification of other solid tumor indications where CD3 bispecifics may serve an unmet need. By analyzing tumor biopsies taken prior to treatment, early on-treatment, and at progression (NCT02570308), using RNA sequencing (RNA-seq) and immunohistochemistry (IHC), we show that expression of interferon-related genes in the tumor …

Sustainable Cash Flow Management Strategies For Small To Medium-Sized Service Businesses, Melody Gray

Walden Dissertations and Doctoral Studies

Nearly 50% of small to medium-sized enterprises (SMEs) fail within five years, resulting in financial losses for business owners and reduced employment opportunities. Entrepreneurs care about this issue because poor cash flow management is a major contributor to business failure, threatening economic growth and job stability. Grounded in working capital management, the purpose of this qualitative, multiple case study is to explore successful cash flow management strategies for service industry SME owners to sustain free cash flow beyond 5 years. The study included four SME owner participants in the Dallas/Fort Worth metroplex who successfully started and sustained the business beyond …

Effects Of Two Years Of Blended Learning On High School Students’ Mathematics Growth In An International School In Kuwait, Maya Bilal Hashisho

Walden Dissertations and Doctoral Studies

Blended learning using a learning management system was implemented in a gender-segregated American school in Kuwait but not evaluated to determine instructional effectiveness. Thus, the purpose of this quantitative study was to compare student performance to determine to what extent there were differences in mathematical growth from Grade 8 to Grade 10 between male and female students who were taught with the traditional classroom approach versus those taught with blended learning in an international school in Kuwait where education is segregated by gender. Grounded in the substitution, augmentation, modification, and redefinition model, this quasi-experimental study involved using pre and post …

Staff Education To Structured Bedside Handoff, Kevin Omwanghe

Walden Dissertations and Doctoral Studies

Nursing bedside handover (NBH) strategies as a nursing practice is often implemented at the patient’s bedside to improve communication safety during the shift change. This practice is vulnerable due to inconsistent application among nurses. This staff education Doctor of Nursing Education project consisted of interviews with staff to explore the barriers to successfully implementing a bedside nurse handoff approach in an intermediate care unit and introducing a staff education program to increase staff knowledge of NBH. Ten registered nurses participated in this project. Results of the pre-education program survey revealed that 100% of the participants had participated in interviews related …

Effective Strategies Restaurant Owners Use To Retain Employees, Olivia Patriece Leonard

Walden Dissertations and Doctoral Studies

Employee retention is a persistent challenge in the restaurant industry. Business owners are particularly concerned because frequent staff departures can disrupt operations, increase training costs, and ultimately threaten business profitability. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry study was to identify restaurant owners’ effective retention strategies in Birmingham, AL. Data sources included semistructured interviews, public data such as disseminated reports and websites, literature, including books, and peer-reviewed articles. Thematic analysis of the data resulted in four themes: (a) compensation, (b) acknowledgment and rewards, (c) management practices, and (d) a positive working environment. A key recommendation …

Anchoring ‘Neo-Hahnian Outdoor Education’ In The Cold War Era: A History Of Character Building In The Outward Bound Movement, Jayson Seaman

Faculty Publications

The invitation to comment on a foundational early article from the JAEOL provided a welcome opportunity to engage with Andrew Brookes’s trilogy of ‘neo-Hahnian outdoor education’ critiques (Brookes, 2003a, 2003b, 2023). In this article, I approach outdoor education’s character building ideology by using archival and secondary sources to situate its evolution in four periods corresponding with major geopolitical and cultural movements: (1) 1941–1945 when Outward Bound (OB) was established; (2) 1946–1952 when Hahn exported OB from his perch at Gordonstoun; (3) 1953–1967 when OB expanded to the U.S. and replicated globally, and (4) 1968–1976 when human potentialism replaced muscular Christianity …

Development Of Isoscapes For Hong Kong Freshwater Streams As A Basis For Ecological Studies, Hon Tim Yip

Lingnan Theses (MPhil & PhD)

Applications of isoscapes in terrestrial and marine ecosystems have grown notably as a tool for studying animal movement. However, isoscapes are rarely used in freshwater ecosystem because current iterations of isoscapes commonly model baseline distributions of bulk stable isotope analysis (SIA) data, which may be inadequate for providing the necessary resolution for fine spatial scale stream environments. This issue could potentially be addressed using compound specific stable isotope analysis, a new method that measures the isotopic composition of individual compounds to provide more comprehensive information than bulk SIA. My study focuses on δ¹³C of essential amino acids (EAA-δ …

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

Do Pro-Environmental Factors Lead To Customers’ Purchase Intention Of Home Energy Management System? The Moderating Effects Of Energy-Efficient Habits, Maryam Zidehsaraei, Minoo Zidehsaraei, Kourosh Esfandiar

Research outputs 2022 to 2026

Environmental challenges, encompassing climate change and global warming, compel consumers to alter their consumption habits. Although there has been a notable surge in consumer awareness regarding pro-environmental practices, especially concerning home energy, there remains a lack of comprehensive research exploring the factors affecting consumers’ willingness to adopt or invest in home energy management system (HEMS) technology. Notably, there have been no studies focused on the factors influencing HEMS purchase intentions (PI) in the Iranian context. Grounded in the theory of planned behavior (TPB) and the norm activation model, this research delves into the PI of Iranian households regarding HEMS, categorizing …

Healthcare Workers' Attitudes And Practices Around Environmental Sustainability In Infection Prevention., Ashley L. Lin, Michelle E. Doll, Rachel J. Pryor, Elizabeth Monsees, Priya Nori, Gonzalo M. Bearman

Manuscripts, Articles, Book Chapters and Other Papers

We assessed healthcare workers' knowledge, attitudes, and practices around disposable personal protective equipment (PPE) use. We observed that healthcare workers are interested in sustainable policies and identified areas for policy changes to reduce PPE waste.

Plasma Proteomic Biomarkers Of Physical Frailty In Heart Failure: A Propensity Score Matched Discovery-Based Pilot Study, Quin Denfeld, Noelle Pavlovic, Christopher Lee, Jon Jacobs, Mary Roberts Davis, Samantha Powell, Marina Gritsenko, Susan Joseph, Beth Habecker

Division of Cardiology Faculty Papers

BACKGROUND: Physical frailty is highly prevalent in heart failure (HF), but we lack an understanding of the underlying pathophysiology. Proteomic evaluation of plasma samples may elucidate potential mechanisms and biomarkers of physical frailty in HF.

OBJECTIVES: We aimed to identify plasma proteomic biomarkers that are differentially expressed between physically frail and non-physically frail adults with HF.

METHODS: This was a secondary analysis of a subset of data and plasma samples from a study of frailty among patients with New York Heart Association (NYHA) Functional Classification I-IV HF. Physical frailty was measured using the Frailty Phenotype Criteria. Propensity score matching was …

Analysis Of Pistachio Shell-Derived Activated Porous Carbon Materials For Hydrogen Adsorption, Setareh Elyasi, Nishar Hameed, Peter J. Mahon, Saulius Juodkazis, Alireza Keshavarz, Stefan Iglauer, Tawanda Matamba, J. Vongsvivut, Nisa V. Salim

Research outputs 2022 to 2026

Developing efficient storage materials is critical for advancing the hydrogen economy. In this study, we aim to utilize plant-based biomass as a sustainable source for fabricating porous carbon (PC) and subsequently employing it for hydrogen adsorption. For the first time, we synthesize highly porous carbon materials from pistachio shells as precursor materials for efficient hydrogen storage. Experiments were conducted to chemically activate pistachio shells using two different agents, sodium chloride (NaCl) and potassium chloride (KCl), at varying ratios. This study evaluates the effectiveness of these chemical activation agents in enhancing the surface area of PC and, consequently, its hydrogen adsorption …

Nitrate Ameliorates Alcohol-Induced Cognitive Impairment Via Oral Microbiota, Xiangxue Li, Zhaojun Ni, Weixiong Shi, Kangqing Zhao, Yanjie Zhang, Lina Liu, Zhong Wang, Jie Chen, Zhoulong Yu, Xuejiao Gao, Ying Qin, Jingwen Zhao, Wenjuan Peng, Jie Shi, Thomas R Kosten, Lin Lu, Lei Su, Yanxue Xue, Hongqiang Sun

Faculty, Staff and Students Publications

Alcohol use is associated with cognitive impairment and dysregulated inflammation. Oral nitrate may benefit cognitive impairment in aging through altering the oral microbiota. Similarly, the beneficial effects of nitrate on alcohol-induced cognitive decline and the roles of the oral microbiota merit investigation. Here we found that nitrate supplementation effectively mitigated cognitive impairment induced by chronic alcohol exposure in mice, reducing both systemic and neuroinflammation. Furthermore, nitrate restored the dysbiosis of the oral microbiota caused by alcohol consumption. Notably, removing the oral microbiota led to a subsequent loss of the beneficial effects of nitrate. Oral microbiota from donor alcohol use disordered …

Exploring Non-Traditional Yeast For Flavor Innovation In Non-Alcoholic Beer, Andrew Maust, Rahul Sen, Scott Lafontaine

Food Science Faculty Publications and Presentations

The demand for nonalcoholic beer (NAB) is growing, with nontraditional yeast strains emerging as valuable tools for brewers to craft distinct NABs. However, independent information about the performance of these commercially available yeasts remains limited. In this study, 11 nontraditional yeast strains were evaluated at two wort nutrient levels to assess their impact on beer chemistry, sensory attributes, and volatile profiles. Basic fermentation metrics were monitored, followed by descriptive sensory analysis and GC-MS/MS quantification of volatile compounds. Results revealed significant differentiation among yeast strains with unique aroma and flavor profiles driven by variations in ester production, fusel alcohol synthesis, and …

Robust Inference For The Unification Of Confidence Intervals In Meta-Analysis, Wei Liang, Haicheng Huang, Hongsheng Dai, Yinghui Wei

School of Engineering, Computing and Mathematics

Traditional meta-analysis assumes that the effect sizes estimated in individual studies follow a Gaussian distribution. However, this distributional assumption is not always satisfied in practice, leading to potentially biased results. In the situation when the number of studies, denoted as K, is large, the cumulative Gaussian approximation errors from each study could make the final estimation unreliable. In the situation when K is small, it is not realistic to assume the random effect follows Gaussian distribution. In this paper, we present a novel empirical likelihood method for combining confidence intervals under the meta-analysis framework. This method is free of the …

Immunotherapeutic Strategies In Head And Neck Cancer: Challenges And Opportunities, Xia Liu, R. Alex Harbison, Mark A. Varvares, Sidharth V. Puram, Guangyong Peng

2020-Current year OA Pubs

HNSCC remains a substantial health issue, with treatment options including surgery, radiation, and platinum-based chemotherapy. Unfortunately, despite progress in research, only modest gains have been made in disease control, with existing treatments resulting in significant functional and quality-of-life issues. The introduction of immunotherapy in the treatment of HNSCC has resulted in some improvements in outlook for patients and is now standard of care for populations with both recurrent and metastatic disease. However, despite the early successes, responses to immune checkpoint inhibition (ICI) remain modest to low, approaching 14%-22% objective response rates. Challenges to the effectiveness of ICI and other immunotherapies …

Understanding Implementation Determinants Of Universal School Meals Through An Equity-Driven Mixed Methods Approach, Gabriella M Mcloughlin, Molly Kerstetter, Yerusalem Yohannes, Omar Martinez, Resa M Jones, Ross C Brownson, Jennifer O Fisher

2020-Current year OA Pubs

BACKGROUND: Policies, such as Universal School Meals (USM), are essential for preventing inequities in chronic disease risk among socially and economically marginalized populations. Implementing USM reduces food insecurity and obesity risk, among other academic/health outcomes; unfortunately, across the nation student participation (i.e., reach) is lower than expected, limiting its public health impact. Grounded in implementation science and health equity frameworks, this study aimed to: 1) investigate the determinants of implementing USM in a large, urban school district and 2) assess key challenges and supports across schools with varying levels of participation in USM.

METHODS: A needs and assets assessment was …

Label-Free Evaluation Of Mouse Embryo Quality Using Time-Lapse Bright Field And Optical Coherence Microscopy, Fei Wang, Senyue Hao, Kibeom Park, Ali Ahmady, Chao Zhou

2020-Current year OA Pubs

The selection of high-quality embryos is essential to enhance the implantation rate for in vitro fertilization (IVF). Optical coherence microscopy (OCM) can noninvasively provide three-dimensional (3D) high-resolution imaging of developing embryos. The revealed microstructures can be used for accurate embryo evaluation. Here, we acquire time-lapse 3D OCM images with co-registered bright-field imaging on mouse embryo development from the one-cell stage to the fully hatched blastocyst inside an incubator. Our results demonstrate the capability of OCM to detect structural features of the developing embryos. The second and third embryonic cell cycles are indicated to be associated with blastocyst formation and the …

Cerebrospinal Fluid Proteomics Identification Of Biomarkers For Amyloid And Tau Pet Stages, Zhibo Wang, Yuhan Chen, Katherine Gong, Bote Zhao, Yuye Ning, Meilin Chen, Yan Li, Muhammad Ali, Jigyasha Timsina, Menghan Liu, Carlos Cruchaga, Jianping Jia

2020-Current year OA Pubs

Accurate staging of Alzheimer's disease (AD) pathology is crucial for therapeutic trials and prognosis, but existing fluid biomarkers lack specificity, especially for assessing tau deposition severity, in amyloid-beta (Aβ)-positive patients. We analyze cerebrospinal fluid (CSF) samples from 136 participants in the Alzheimer's Disease Neuroimaging Initiative using more than 6,000 proteins. We apply machine learning to predict AD pathological stages defined by amyloid and tau positron emission tomography (PET). We identify two distinct protein panels: 16 proteins, including neurofilament heavy chain (NEFH) and SPARC-related modular calcium-binding protein 1 (SMOC1), that distinguished Aβ-negative/tau-negative (A-T-) from A+ individuals and nine proteins, such as …

Outcomes Evidence Must Keep Up With The Implementation Of The 4ms Framework To Ensure Age-Friendly Health System Transformation, James D Harrison, Stephanie E Rogers, Benjamin Rosner, Estelle Martin, Sunny C Lin, Jarmin Yeh, Julia Adler-Milstein

2020-Current year OA Pubs

The Age-Friendly Health System (AFHS) movement was conceptualized as a transformative solution to reliably deliver evidence-based care to older adults. Guided by the 4Ms framework: What Matters, Mobility, Mentation, and Medication, AFHS healthcare systems have been given the flexibility to tailor 4Ms interventions and care processes to their context, preferences and populations. This flexibility has facilitated the widespread adoption of 4Ms care. However, as our understanding of 4Ms implementation grows, evidence of the impact of 4Ms care on outcomes must keep up with implementation to ensure AFHS transformation. It is only through assessing the 4Ms as a whole and understanding …

Synapsin Condensation Is Governed By Sequence-Encoded Molecular Grammars, Christian Hoffmann, Kiersten M Ruff, Irina A Edu, Min Kyung Shinn, Johannes V Tromm, Matthew R King, Avnika Pant, Hannes Ausserwöger, Jennifer R Morgan, Tuomas P J Knowles, Rohit V Pappu, Dragomir Milovanovic

2020-Current year OA Pubs

Multiple biomolecular condensates coexist at the pre- and post- synapse to enable vesicle dynamics and controlled neurotransmitter release in the brain. In pre-synapses, intrinsically disordered regions (IDRs) of synaptic proteins are drivers of condensation that enable clustering of synaptic vesicles (SVs). Using computational analysis, we show that the IDRs of SV proteins feature evolutionarily conserved non-random compositional biases and sequence patterns. Synapsin-1 is essential for condensation of SVs, and its C-terminal IDR has been shown to be a key driver of condensation. Focusing on this IDR, we dissected the contributions of two conserved features namely the segregation of polar and …

Attitudes Of Female Carriers Of X-Linked Hypohidrotic Ectodermal Dysplasia Towards Prenatal Treatment And Their Decisions During A Pregnancy With A Male Fetus, Holm Schneider, Michael Schneider, Massimiliano Lia, Dorothy K Grange, Smail Hadj-Rabia, Angus Clarke, Mary Fete, Agnes Jaulent, Marlene Guiraud, Anthony Odibo, Florian Faschingbauer

2020-Current year OA Pubs

BACKGROUND: X-linked hypohidrotic ectodermal dysplasia (XLHED) is a severe genetic disorder that may be treatable with short-term protein replacement therapy during fetal development. This is currently being investigated in a multicenter clinical trial. Affected fetuses can be identified by the number of tooth germs during a routine ultrasound scan in mid-gestation. To understand the attitudes of female XLHED carriers towards prenatal treatment and ultrasonographic screening of the fetus, we analyzed an earlier and a very recent survey among those women and the actual decisions of potential trial participants.

METHODS: Initial analyses were based on a self-administered survey of 167 female …

Mri Distance Measures As A Predictor Of Subsequent Clinical Status During The Preclinical Phase Of Alzheimer's Disease And Related Disorders, Xinyi Zhang, John C Morris, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

Brain atrophy over time, as measured by magnetic resonance imaging (MRI), has been shown to predict subsequent cognitive impairment among individuals who were cognitively normal when first evaluated, indicating that subtle brain atrophy associated with Alzheimer's disease (AD) may begin years before clinical symptoms appear. Traditionally, atrophy has been quantified by differences in brain volume or thickness over a specified timeframe. Research indicates that the rate of atrophy varies across different brain regions, which themselves exhibit complex spatial and hierarchical organizations. These characteristics collectively emphasize the need for diverse summary measures that can effectively capture the multidimensional nature of degeneration. …

Facpaac Minutes 04/15/2025, Faculty And P&A Affairs Committee

Faculty and P&A Affairs Committee

Includes minutes from the 04/15/2025 meeting as well as the summary of the results of FACPAAC 2025 survey of current work conditions on campus.

Steering Minutes 04/15/2025, Steering Committee

Steering Committee

No abstract provided.

Who Needs More Than 1 Water Bottle? Apparently, Everyone., Jazmyn Weddig

Honors Theses

This research investigates the interplay between a good’s functional durability, and its collectability, focusing on the Stanley Quencher water bottle market as a case in point, which has recently gained widespread consumer interest. It examines the economic and psychological factors driving consumer behavior and the market dynamics associated with durable goods that become collectibles. This paper begins with a comprehensive analysis of Stanley and the history of the company to provide a better understanding of their evolving marketing strategies. This paper takes special interest in collecting behavior, planned obsolescence, market structures and economic utility to help explain consumer behavior within …

Empowering Consumers: The Impact Of Awareness On Skill Development And Assertiveness In Market Engagement, Megawati Simanjuntak

Journal of Marketing and Consumer Behaviour in Emerging Markets

Consumer empowerment focuses on the knowledge, attitudes, skills, and advocacy that enable consumers to recognize and defend their rights and responsibilities. This study aims to explore the relationship between consumer awareness, skills, and assertiveness, highlighting the role of consumer empowerment in defending their rights. The study involves 2,600 respondents, consisting of 1,400 individuals from urban areas and 1,200 individuals from rural areas, analysed using Structural Equation Modelling (SEM). The findings reveal that consumer awareness significantly enhances both skills and assertiveness. Additionally, consumer skills serve as a mediator linking awareness and assertiveness. This research emphasizes that higher awareness among consumers can …