Digital Commons Network^™

Left Ventricular Entry To Reduce Brain Lesions During Catheter Ablation: A Randomized Trial, Gregory M Marcus, Roderick Tung, Edward P Gerstenfeld, Trisha F Hue, Feng Lin, Jing Cheng, J Peter Weiss, Wendy S Tzou, Henry Hsia, Ashkan Ehdaie, Daniel H Cooper, T Jared Bunch, Jeffrey Arkles, Babak Nazer, Adam Lee, Alexios Hadjis, Duy T Nguyen, Mihail G Chelu, Joshua Moss, Jonathan C Hsu, Miguel Valderrábano, Prashant D Bhave, Andrew D Beaser, Arvindh Kanagasundram, Oussama Wazni, Jason Bradfield, Grace Wall, Kathleen Chang, Michelle Yang, Gabrielle Montenegro, Sabrina Jarrott, Joel H Kramer, Anthony S Kim, Yvonne M Morris, William P Dillon

Faculty, Staff and Students Publications

Background: Catheter ablation of ventricular arrhythmias, one of the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging-detected brain lesions in more than half of cases. Although a retrograde aortic approach is conventional, modern tools enable entry through a transseptal approach that may avoid embolization of debris from the arterial system. We sought to test the hypothesis that a transseptal puncture would mitigate brain injury compared with a retrograde aortic approach.

Methods: The TRAVERSE trial (Transseptal Versus Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli) was a multicenter randomized controlled comparative effectiveness trial. Patients with left …

Morphogenic, Molecular And Cellular Adaptations For Unidirectional Airflow In The Chicken Lung, Kamryn N Gerner-Mauro, Lisandra Vila Ellis, Guolun Wang, Richa Nayak, Peter Y Lwigale, Ross A Poché, Jichao Chen

Faculty, Staff and Students Publications

Unidirectional airflow in the avian lung enables gas exchange during both inhalation and exhalation. The underlying developmental process and how it deviates from that of the bidirectional mammalian lung are poorly understood. Sampling key developmental stages with multiscale 3D imaging and single-cell transcriptomics, we delineate morphogenic, molecular and cellular features that accommodate the unidirectional airflow in the chicken lung. Primary termini of hyper-elongated branches undergo proximal-short and distal-long fusions, forming parabronchi for air conduction. Through the parabronchial smooth muscle, neoform termini extend radially to form gas-exchanging alveoli. Supporting this radial alveologenesis, branch stalks halt their proximalization, defined by SOX9-SOX2 transition, …

Lineage Tracing And Single-Cell Rna Sequencing Reveal A Common Transcriptional State In Breast Cancer Tumor-Initiating Cells Characterized By Ifn/Stat1 Activity, Eric P Souto, Ping Gong, John D Landua, Ramakrishnan Rajaram Srinivasan, Abhinaya Ganesan, Lacey E Dobrolecki, Stephen C Purdy, Xingxin Pan, Michael Zeosky, Anna Chung, S Stephen Yi, Heide L Ford, Michael T Lewis

Faculty, Staff and Students Publications

A tumor cell subpopulation of tumor-initiating cells (TIC) or "cancer stem cells" is associated with therapeutic resistance, as well as both local and distant recurrences. Signal transducer and activator of transcription (STAT) activity is elevated in TICs in claudin-low models of human triple-negative breast cancer, which enables enrichment of TICs using a STAT-responsive reporter. Lineage tracing of TICs as they undergo cell state changes could enable a better understanding of the molecular phenotypes of TIC and uncover strategies to selectively target TICs. In this study, we developed a STAT-responsive lineage-tracing system and used it in conjunction with the original reporter …

A Screening Question To Assess Risk Of Using Antibiotics Without A Prescription: A Diagnostic Study, Ashley Collazo, Eva Amenta, Kiara Olmeda, Marissa Valentine-King, Lindsey Laytner, Azalia Mancera, Roger Zoorob, Michael K Paasche-Orlow, Richard L Street, Barbara W Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

Objectives: Non-prescription antibiotic use (using antibiotics without medical advice) is potentially unsafe and promotes antimicrobial resistance. We studied predictors of prior non-prescription use and whether screening for prior non-prescription antibiotic use predicted intention of future non-prescription antibiotic use.

Methods: The survey was performed from January 2020 - June 2021 in six public primary care clinics and two private emergency departments. Prior non-prescription users were respondents who reported taking oral antibiotics for symptoms without contacting a clinician. Intended use was defined by answering yes to the question, "would you use antibiotics without contacting a doctor/nurse/dentist/clinic." We examined predictors for prior non-prescription …

Staff Update On Type 2 Diabetes Education, Toochukwu Endaline Mba

Walden Dissertations and Doctoral Studies

The current rise in Type 2 diabetes among middle-aged individuals poses significant risks of health complications such as kidney damage, heart disease, stroke, nerve damage, vision loss, and skin problems. Research has shown that proper education on the causes and risk factors of Type 2 diabetes would increase people’s knowledge about the medical problem, helping promote positive health outcomes. This project was a staff education program using didactic and interactive case studies.

Clinical Practice Guideline Workflow For Medication Prescription, Patience Morikang

Walden Dissertations and Doctoral Studies

The type of project was a clinical practice guideline (CPG) workflow for medication prescriptions. The practice problem was the lack of an evidence-based approach regarding medication prescriptions, resulting in increased errors. It is essential to address this problem to promote safe prescribing, increase team knowledge, and encourage patient safety in the organization and within nursing practice. The practice focused question was the following: Will a clinical practice guideline for medication prescription workflow be approved by experts for use in an outpatient mental health clinic to promote the reduction of errors? The project aimed to seek expert approval of a CPG …

Title 1 Third-Grade Teachers' Experiences With Writing Strategies To Improve Students' Writing Proficiency, Kim Robertson

Walden Dissertations and Doctoral Studies

Third-grade students are not meeting minimum proficiency in opinion and informational writing, as determined by scores from the annually mandated Georgia Milestones Assessment (GMAS) in the 19 elementary schools in a local school district in central Georgia. Guided by Vygotsky’s social-constructivist perspective, the purpose of this basic qualitative study was to explore Title 1 third-grade English Language Arts teachers’ experiences with using writing strategies designed to improve students’ writing proficiency on the GMAS in the Title 1 elementary schools in a local district in central Georgia. Data were collected using semistructured interviews with 10 third-grade teachers who were chosen from …

Numerical Analysis Of The Seir Model, Abigail R. Beckelhimer

Departmental Honors & Graduate Capstone Projects

Epidemiological models delineate the spread of diseases within a population. In this research project, the Susceptible-Exposed-Infected-Recovered (SEIR) Model was examined numerically for comparison between several methods. Approximations were obtained through Euler’s Method, Taylor’s Method, Runge-Kutta Methods, and Multi-step Methods. Hypothetical situations with parameter alterations were considered in order to better understand the effects the parameters have on the model. The goal of this project was to portray the usefulness of numerical approximations for predicting the behavior of the SEIR model and thus the course of a pandemic.

Academic Senate - Agenda, 4/15/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

Aesthetics In Instructional Design, Dennis M. West

Theses and Dissertations

This multi-article dissertation examines how aesthetics enhances instructional design to foster engaging, transformative learning experiences. Despite its potential, aesthetics is often granted a secondary status in design practice, being seen as less important than functionality. The first article explores philosopher Monroe Beardsley's five aesthetic criteria--object-directedness, felt freedom, detached affect, active discovery, and wholeness--through a theoretical literature review, proposing their application to elevate learner engagement and interest. The second article, a qualitative investigation, analyzed the Cybermatics Playable Case Study (PCS; a cybersecurity simulation) from the perspective of Beardsley's aesthetic criteria. This investigation involved four students and two designers interviewed hermeneutically over …

Analysis Of Radial Inlet Distortion On Transonic Fan Performance, Tyler M. Reedy

Theses and Dissertations

Improving fan design and performance prediction requires an understanding of the impacts of inlet distortions. Inlet distortion describes any non-uniform distribution in the flow, usually referring to deviations in pressure and temperature. Using full annulus Unsteady Reynolds-Averaged Navier Stokes (URANS) simulations, the effects of both hub and tip radial distortions on the Air Force Research Lab (AFRL) Rotor 4 fan are analyzed. Overall performance, total pressure (Pt) distortion transfer, and total temperature (Tt) distortion generation are presented and compared for three operating points: near-stall, design, and choke. Hub radial inlet distortion magnitudes of 15% and 20%, and a tip radial …

Data Quality And Enterprise Architecture: An Analysis Of The Awareness And Knowledge Of Data Quality Artifacts, Principles, Practices, And Application In Enterprise Architecture, Jason Alan Minton

Theses and Dissertations

Enterprise Architecture (EA) is a discipline, approach, and practice that aims to align the enterprise’s technical infrastructure, strategy, processes, and technology investments with the organization’s strategy to fulfill the mission and vision. Data quality is conformance to data specifications (Talburt, 2015, p. 192), and low data quality has significant implications for decisions and outcomes across the enterprise. Scant literature and research exist surrounding the intersection, integration, and impact of data quality within EA practices. This research examines the awareness and understanding of Enterprise Architect and Technology Architect populations regarding data quality concepts, artifacts, and tools. The research aims to answer …

Preservation And Integrity Of Laboratory Solutions: Understanding The Impact Of Storage Practices On Chemical Stability And Experimental Accuracy, Azza Al Jahdhami

Honors Theses

Chemical storage methods represent a key matter ignored within labs, educational sites, workplaces, and even households. Many people, including various students and instructors within the chemistry field, are unaware of the proper methods for storing and disposing of common chemicals. This study aims to understand the effects of storage practices on chemical stability and experimental accuracy, dealing with the following questions: What kind of effects result from improper chemical disposal? How can improper storage affect the overall chemical effectiveness? Why is sink disposal of many solutions discouraged, and why is waste container disposal always necessary?

Through a literature review, this …

Evaluating The Potential For Reusing Process Waste Fiber, Elisha Ewing

Honors Theses

This study was born out of curiosity around the potential use of reject materials from the papermaking screening system for molded fiber product development. The team sought to explore the technical feasibility of this concept and develop a proposed design for mill implementation. The project supports the common papermaking objective of reducing fiber loss from the stock preparation process.

The project assessed first the technical feasibility through laboratory testing and trials. The team dedicated time to characterizing screen reject samples from local mills and running trials using the good fibers extracted from the samples. Molded fiber products were successfully created …

Nanostructured Transition Metal Oxides For Electrochemical Co2 And Methane Conversion, Olumide O. Oladoyin

Chemical and Biological Engineering ETDs

Rising atmospheric CO₂ and CH₄ drive climate change, prompting research into their electrochemical conversion to valuable products. This study investigates electrodeposited nanostructured transition metal oxides (TMOs), unary (CuO, Co₃O₄) and dual (Cu-Co oxide) as catalysts for CO₂ reduction and CH₄ oxidation under ambient conditions. Fabricated on various substrates (Cu foil, SS316, carbon paper) and characterized by SEM, their electrochemical performance was evaluated via cyclic voltammetry.

Cu-Co oxide showed superior CO₂ reduction, leveraging the strengths of individual oxides. Co₃O₄ exhibited higher current densities for CH₄ oxidation, with SS316 proving the best substrate. Catalyst composition, morphology, and substrate significantly influenced efficiency. While …

Evolution Of The Tumor Immune Landscape During Treatment With Tebentafusp, A T Cell Receptor-Cd3 Bispecific, Joseph Sacco, Peter Kirk, Emma Leach, Alexander Shoushtari, Richard Carvajal, Camille Britton-Rivet, Sophie Khakoo, Laura Collins, Luis De La Cruz-Merino, Zeynep Eroglu, Alexandra Ikeguchi, Paul Nathan, Omid Hamid, Marcus Butler, Sarah Stanhope, Koustubh Ranade, Takami Sato

Department of Medical Oncology Faculty Papers

Metastatic uveal melanoma is an aggressive disease with poor outcome, which is refractory to immune checkpoint inhibitors. A T cell receptor (TCR)-based CD3 bispecific, tebentafusp, delivers clinical benefit in patients with metastatic uveal melanoma. Understanding the molecular basis for the anti-tumor activity of tebentafusp in an indication where checkpoint inhibitors are ineffective could aid in identification of other solid tumor indications where CD3 bispecifics may serve an unmet need. By analyzing tumor biopsies taken prior to treatment, early on-treatment, and at progression (NCT02570308), using RNA sequencing (RNA-seq) and immunohistochemistry (IHC), we show that expression of interferon-related genes in the tumor …

Sustainable Cash Flow Management Strategies For Small To Medium-Sized Service Businesses, Melody Gray

Walden Dissertations and Doctoral Studies

Nearly 50% of small to medium-sized enterprises (SMEs) fail within five years, resulting in financial losses for business owners and reduced employment opportunities. Entrepreneurs care about this issue because poor cash flow management is a major contributor to business failure, threatening economic growth and job stability. Grounded in working capital management, the purpose of this qualitative, multiple case study is to explore successful cash flow management strategies for service industry SME owners to sustain free cash flow beyond 5 years. The study included four SME owner participants in the Dallas/Fort Worth metroplex who successfully started and sustained the business beyond …

Effects Of Two Years Of Blended Learning On High School Students’ Mathematics Growth In An International School In Kuwait, Maya Bilal Hashisho

Walden Dissertations and Doctoral Studies

Blended learning using a learning management system was implemented in a gender-segregated American school in Kuwait but not evaluated to determine instructional effectiveness. Thus, the purpose of this quantitative study was to compare student performance to determine to what extent there were differences in mathematical growth from Grade 8 to Grade 10 between male and female students who were taught with the traditional classroom approach versus those taught with blended learning in an international school in Kuwait where education is segregated by gender. Grounded in the substitution, augmentation, modification, and redefinition model, this quasi-experimental study involved using pre and post …

Staff Education To Structured Bedside Handoff, Kevin Omwanghe

Walden Dissertations and Doctoral Studies

Nursing bedside handover (NBH) strategies as a nursing practice is often implemented at the patient’s bedside to improve communication safety during the shift change. This practice is vulnerable due to inconsistent application among nurses. This staff education Doctor of Nursing Education project consisted of interviews with staff to explore the barriers to successfully implementing a bedside nurse handoff approach in an intermediate care unit and introducing a staff education program to increase staff knowledge of NBH. Ten registered nurses participated in this project. Results of the pre-education program survey revealed that 100% of the participants had participated in interviews related …

Effective Strategies Restaurant Owners Use To Retain Employees, Olivia Patriece Leonard

Walden Dissertations and Doctoral Studies

Employee retention is a persistent challenge in the restaurant industry. Business owners are particularly concerned because frequent staff departures can disrupt operations, increase training costs, and ultimately threaten business profitability. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry study was to identify restaurant owners’ effective retention strategies in Birmingham, AL. Data sources included semistructured interviews, public data such as disseminated reports and websites, literature, including books, and peer-reviewed articles. Thematic analysis of the data resulted in four themes: (a) compensation, (b) acknowledgment and rewards, (c) management practices, and (d) a positive working environment. A key recommendation …

Anchoring ‘Neo-Hahnian Outdoor Education’ In The Cold War Era: A History Of Character Building In The Outward Bound Movement, Jayson Seaman

Faculty Publications

The invitation to comment on a foundational early article from the JAEOL provided a welcome opportunity to engage with Andrew Brookes’s trilogy of ‘neo-Hahnian outdoor education’ critiques (Brookes, 2003a, 2003b, 2023). In this article, I approach outdoor education’s character building ideology by using archival and secondary sources to situate its evolution in four periods corresponding with major geopolitical and cultural movements: (1) 1941–1945 when Outward Bound (OB) was established; (2) 1946–1952 when Hahn exported OB from his perch at Gordonstoun; (3) 1953–1967 when OB expanded to the U.S. and replicated globally, and (4) 1968–1976 when human potentialism replaced muscular Christianity …

Development Of Isoscapes For Hong Kong Freshwater Streams As A Basis For Ecological Studies, Hon Tim Yip

Lingnan Theses (MPhil & PhD)

Applications of isoscapes in terrestrial and marine ecosystems have grown notably as a tool for studying animal movement. However, isoscapes are rarely used in freshwater ecosystem because current iterations of isoscapes commonly model baseline distributions of bulk stable isotope analysis (SIA) data, which may be inadequate for providing the necessary resolution for fine spatial scale stream environments. This issue could potentially be addressed using compound specific stable isotope analysis, a new method that measures the isotopic composition of individual compounds to provide more comprehensive information than bulk SIA. My study focuses on δ¹³C of essential amino acids (EAA-δ …

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

Who Needs More Than 1 Water Bottle? Apparently, Everyone., Jazmyn Weddig

Honors Theses

This research investigates the interplay between a good’s functional durability, and its collectability, focusing on the Stanley Quencher water bottle market as a case in point, which has recently gained widespread consumer interest. It examines the economic and psychological factors driving consumer behavior and the market dynamics associated with durable goods that become collectibles. This paper begins with a comprehensive analysis of Stanley and the history of the company to provide a better understanding of their evolving marketing strategies. This paper takes special interest in collecting behavior, planned obsolescence, market structures and economic utility to help explain consumer behavior within …

Empowering Consumers: The Impact Of Awareness On Skill Development And Assertiveness In Market Engagement, Megawati Simanjuntak

Journal of Marketing and Consumer Behaviour in Emerging Markets

Consumer empowerment focuses on the knowledge, attitudes, skills, and advocacy that enable consumers to recognize and defend their rights and responsibilities. This study aims to explore the relationship between consumer awareness, skills, and assertiveness, highlighting the role of consumer empowerment in defending their rights. The study involves 2,600 respondents, consisting of 1,400 individuals from urban areas and 1,200 individuals from rural areas, analysed using Structural Equation Modelling (SEM). The findings reveal that consumer awareness significantly enhances both skills and assertiveness. Additionally, consumer skills serve as a mediator linking awareness and assertiveness. This research emphasizes that higher awareness among consumers can …

Spartan Daily, April 15, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 32

Volumetric Changes In Cerebellar Transverse Zones: Age And Sex Effects In Health And Neurological Disorders, Farshid Ghiyamihoor, Payam Paymani, Jarrad Perron, Azam Asemi-Rad, Mehdi Marzban, Aashka Mohite, Karen Ardila, Bara Aljada, Asghar Marzban, Mehnosh Toback, Sherif Eltonsy, Ji Hyun Ko, Tabrez J Siddiqui, Christopher J Steele, Jiming Kong, Mario Manto, M Ethan Macdonald, Jason S Gill, Roy V Sillitoe, Fuat Balcı, Iman Beheshti, Hassan Marzban

Duncan NRI Faculty and Staff Publications

Cerebellar volumetric changes are intricately linked to aging, with distinct patterns across its transverse zones, the functional subdivisions characterized by unique cytoarchitectural and connectivity profiles. Despite research efforts, the cerebellar aging process in health and neurological disorders remains poorly understood. In this study, we investigated the effects of age and sex on total cerebellum, transverse zone, and lobule volumes using MRI data from over 45,000 participants compiled from six neuroimaging datasets. We also propose a framework for estimating cerebellum age as an indicator of cerebellar health. Significant age‐dependent volume reductions were observed across transverse zones, with the …

Developing Adaptive Expertise To Support All Learners: An Autoethnographic Investigation Of My Teaching Journey, Jennifer Zacuto

LMU Theses and Dissertations

Entering the profession with vastly different preparation and perspectives, teachers encounter diverse students, complex contexts, and shifting expectations for which they frequently find themselves underprepared by their preservice training. With greater awareness emerging about the significant effect that individual teachers have on student outcomes, and an understanding that the knowledge and mindsets needed for optimal instruction cannot be fully developed during preservice education, teachers need effective paths for ongoing professional development (PD). Self-directed PD, with its capacity for customization in content and pacing, has the potential to more effectively foster meaningful and continuous teacher learning. Through autoethnographic methods (e.g., Adams …

Psychrotrophic Antarctic Marine Bacteria As Potential Reservoirs For Novel Antimicrobial Genes, Kudzai Hwengwere, Grant G. January, Kerry L. Howell, Lloyd S. Peck, Mathew Upton, Melody S. Clark

School of Biomedical Sciences

Antarctica is a very cold, isolated continent surrounded by frozen seas, yet these extreme environmental conditions have not restricted life and diversity in the sea. The marine environment is seasonally highly productive and harbours diverse and abundant communities of organisms, with many endemic species occurring nowhere else in the world. Such communities and their associated microbiomes are increasingly recognized as an unexplored source of novel antimicrobial products. Hence, the major aim of this study was to examine the antimicrobial potential of bacteria cultured from eight Antarctic marine invertebrate species, while gathering data on Antarctic microbial thermal and salinity tolerances. All …

Learning By Confusion: The Phase Diagram Of The Holstein Model, George Issa, Owen Bradley, Ehsan Khatami, Richard Scalettar

Faculty Research, Scholarly, and Creative Activity

We employ the "learning by confusion"technique, an unsupervised machine learning approach for detecting phase transitions, to analyze quantum Monte Carlo simulations of the two-dimensional Holstein model - a fundamental model for electron-phonon interactions on a lattice. Utilizing a convolutional neural network, we conduct a series of binary classification tasks to identify Holstein critical points based on the neural network's learning accuracy. We further evaluate the effectiveness of various training datasets, including snapshots of phonon fields and other measurements resolved in imaginary time, for predicting distinct phase transitions and crossovers. Our results culminate in the construction of the finite-temperature phase diagram …