Digital Commons Network^™

Targeting Oncogenic Flt3 Uncovers A Ferroptosis Vulnerability Through Selenocysteine Recoding In Acute Myeloid Leukaemia, Minhua Li, Yudan Zhu, Yuki Kageyama, Ken Furudate, Ayumi Kitano, Taotao Tan, Mengdie Feng, Jing Zhou, Tao Wang, Robert J Taylor, Alexandra M Stevens, Md Abul Hassan Samee, Jeffrey A Magee, Koichi Takahashi, Daisuke Nakada

Faculty, Staff and Students Publications

Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has emerged as a potential therapeutic strategy for therapy-resistant cancers. Glutathione peroxidase 4 and the selenoprotein biosynthesis pathway essential for its translation are key regulators of ferroptosis but lack effective therapeutic targeting. In a drug screening using a selenoprotein translation reporter, here we identify FMS-like tyrosine kinase 3 (FLT3) inhibitors as suppressors of selenoprotein translation that induce ferroptosis in FLT3-mutant acute myeloid leukaemia. Mechanistically, FLT3 inhibition disrupts selenocysteine recoding, in which a UGA stop codon is recoded as selenocysteine via the SECIS element and associated binding proteins. Notably, the …

Linkage And Alcohol Use Outcomes Of A Screening, Brief Intervention, And Referral To Treatment (Sbirt) Program For Alcohol-Related Liver Disease: A Retrospective Cohort Study From India, Abhishek Ghosh, Nipun Verma, Harsh A Thappa, Surabhi Gupta, Renjith R Pillai, Shalini Naik, Arka De, Madhumita Premkumar, B N Subodh, Sunil Taneja, Debasish Basu, Ajay Duseja

Faculty, Staff and Students Publications

Background: Alcohol-related liver disease (ArLD) and alcohol use disorder remain undertreated. Collaborative care embedding addiction services within medical settings have shown promise.

Aim: We evaluated the linkage and alcohol use outcomes of an SBIRT-based collaborative care clinic at a public sector hospital in India, examining rates of linkage to addiction treatment, alcohol use outcomes at follow-up, and factors associated with successful linkage.

Methods: A retrospective cohort study of 500 consecutively enrolled patients was conducted over January 2023-July 2024. Patients with ArLD were systematically screened using the Alcohol Use Disorders Identification Test (AUDIT) and risk-stratified into brief advice, brief counselling, or …

2026 Deerfield Fair 4-H Exhibit Building Premium Book, Extension

UNH Cooperative Extension

No abstract provided.

2026 Deerfield Fair 4-H Animal Premium Book, Extension

UNH Cooperative Extension

No abstract provided.

Air-Assist Or Mist Backpack Sprayer Calibration Worksheet, Amy Papineau

UNH Cooperative Extension

No abstract provided.

What Drives Blockchain Technology Adoption? A Meta-Analysis Across Tam, Tpb, And Utaut Frameworks, Amir Rahmani, Roohollah Ahmadi, Tugrul Unsal Daim, Mehdi Zamani, Dilek Ozdemir

Engineering and Technology Management Faculty Publications and Presentations

Research on blockchain adoption has expanded rapidly, with most studies conceptualizing adoption as behavioural intention. Technology adoption models, such as the Technology Acceptance Model (TAM), the Theory of Planned Behavior (TPB), and the Unified Theory of Acceptance and Use of Technology (UTAUT), are commonly applied to explore blockchain technology adoption (BTA). However, empirical results from the 12 hypotheses associated with these models remain fragmented and, at times, inconsistent, with limited comprehensive quantitative integration. To address this gap, the present study performs a meta-analysis to evaluate the degree and direction of these hypotheses systematically. In accordance with PRISMA guidelines, 149 quantitative …

Book Review Of, Beyond Techno-Economic Diffusion: A Systematic Review And Socio-Technical Audit Of Agent-Based Models Of Rooftop Solar Pv Adoption, Yavuz Unal, Mehmet Kayalica, Denizhan Guven

Engineering and Technology Management Faculty Publications and Presentations

Agent-based modelling (ABM) is increasingly used to analyze rooftop solar photovoltaic (PV) diffusion, yet it remains unclear how existing models operationalize socio-technical mechanisms such as peer effects, grid constraints, policy uncertainty, and energy justice. This systematic review evaluates ABM architectures for rooftop PV diffusion through a three-layer evidence design: a mapping of 876 publications (2000–2025), a core set of 101 ABM-related studies, and structured coding of 50 focal ABMs using the Spatial–Economic–Mechanistic–Policy–Justice (S-E-M-P-J) framework, which tests whether mechanisms are formally implemented rather than narratively invoked. The coding reveals an uneven architecture: behavioural mechanisms are nearly universal (96%) and policy representations …

Georgia Library Spotlight Kennesaw State University Libraries Unveils New Website!, Erica Flint, Brianna Parfaite

Georgia Library Quarterly

No abstract provided.

Georgia Library Spotlight North Cobb Regional Library Launches America 250 Series, Barbara Sonnefeldt

Georgia Library Quarterly

No abstract provided.

Artificial Intelligence And The Thoughtful Reference Librarian At Valdosta State University’S Odum Library: A Practice Brief, Harikleia Georgiou Sirmans

Georgia Library Quarterly

This practice brief examines how reference librarians at Valdosta State University’s Odum Library integrate artificial intelligence into daily work while maintaining institutional policies and core library values. As AI reshapes their roles, they must carefully evaluate, verify, and ethically judge any AI output. They support students and instructors by teaching AI literacy, promoting responsible use, translating institutional policies into practical guidance, and emphasizing critical thinking. The brief also stresses the importance of human judgment, empathy, and professional expertise that AI cannot replace. It concludes with practical steps for academic research. For clarity, this article uses the term “instructors” to refer …

Library Of Congress Honors Georgia Library Service For The Blind And Print Disabled, Deborah Hakes

Georgia Library Quarterly

No abstract provided.

How Can We Help? An Exploration Into Graduate Student And Faculty Perceptions And Use Of Georgia Library Learning Online (Galileo), Jessica Banks, Whit Gaines, Michelle Jones

Georgia Library Quarterly

The authors explored the knowledge graduate students and faculty in Columbus State University’s College of Education and Health Professions have surrounding the Georgia Library Learning Online (GALILEO) platform. Additionally, the authors wanted to determine how students used GALILEO and how faculty may have supported their efforts. Quantitative and qualitative data were collected to explore the questions posed. Quantitative data included usage reports from GALILEO and descriptive statistics. Qualitative data were coded to determine themes and opinions of faculty/students. Quantitative reports showed the databases students prefer and how they prefer to use them. The qualitative findings showed that faculty may not …

The Evolution Of The Modern Library Brand: Transforming Community Engagement Into Sustainable Revenue, Slone Williams

Georgia Library Quarterly

This article examines the development of the Cobb Library Shop, an e-commerce initiative launched by the Cobb County Public Library to generate sustainable funding through brand engagement. Built on a modest startup budget, the shop integrates a multichannel sales strategy and leverages internal talent to create a scalable, community-centered retail model.

The project achieved a full return on investment within 14 days and continues to demonstrate steady revenue expansion. By combining entrepreneurial practices with public service values, this case study highlights how libraries can diversify funding streams, enhance community engagement, and establish a replicable model for revenue-generating library systems.

Paraeducator Perceptions Of Teacher-Supervisory Behaviors And Their Effects On Paraeducator Retention, Alexis M. Graham

Education Doctoral

Paraeducators are leaving their positions at alarming levels, leaving teachers, students, and schools vulnerable. The exploratory, cross-sectional, correlational survey study examines the relationship between paraeducator perceptions of teacher-supervisor leadership behaviors and retention, as well as the factors contributing to turnover. Full range leadership theory (FRLT) and the Multifactor Leadership Questionnaire (MLQ) are used to describe leadership behaviors. The study used a survey design advertised to a paraeducator Facebook group, which included the MLQ rating scale, a closed-response item on intent to leave, and an open ended question on intent to leave. Data was analyzed using statistical and correlational analyses, as …

A Post-Incarceration Syndrome And Its Impact On Formerly Incarcerated Individuals: A Quantitative Examination Of In-Prison Services And Community Reentry Resources In New York City, Jorge Antonio Diaz

Education Doctoral

The United States incarcerates more individuals than any other nation, yet the effects ofincarceration remain underexamined in quantitative research. Although qualitative research has documented the traumatic sequelae of confinement, including post-incarceration syndrome (PICS), limited work has assessed the perceived adequacy of services available during incarceration, community reentry, and parole supervision. This study addresses that gap through a non-experimental, cross-sectional, descriptive quantitative design. Data were collected from a convenience sample of 31 formerly incarcerated adults using a 40-item researcher-developed tool, the Post-Incarceration Services Assessment Survey (PISAS), which examined perceived adequacy of in-prison coping services, community-based reentry resources, and parole officer support. …

Perceived Professional Investment Differences And Learning Modality Preferences Between Generation X And Millennial Managers In Nonprofit Organizations, Raul Antonio Pereles Jr.

Education Doctoral

This study examines generational differences between Generation X and Millennial nonprofit managers in perceived employer investment in professional development and preferred learning delivery modality. Grounded in Knowles' (1980) theory of andragogy, the study addresses two research questions using a quantitative, cross-sectional survey design. A sample of 66 nonprofit managers (35 Generation X, 31 Millennial) from a major northeastern U.S. metropolitan area completed an online survey using the Professional Development Short Scale (PDSS; Mourão et al., 2014) and a ranked-preference measure of learning modality (in-person, hybrid, virtual). Results indicated no statistically significant difference between Generation X (M = 5.85, SD = …

New York City High School Alumni Perceptions Of A School-Community-Based Organization Partnership, Tasha Cooper

Education Doctoral

This qualitative phenomenological study explored how recent alumni of a New York City public high school described and interpreted their lived experiences with a school–community-based organization (CBO) partnerships through “Program X,” a college and career readiness program. Using semi-structured interviews, the study examined how eight public high school graduates perceived these experiences as influencing their educational decision-making and postsecondary aspirations. Findings revealed that Program X positively influenced the educational decision- making, college readiness, and career aspirations through individualized academic planning, SAT prep, financial aid workshops, college and career events, and mentoring. The participants reported increased motivation, self-efficacy, self-sufficiency, and confidence …

Understanding The Role Of Transformational Leadership In Supporting Well-Being Among Globally Educated Nurses And Contiguous United States Educated Nurses: A Quantitative, Correlational Study, Megan Shone

Education Doctoral

The purpose of this quantitative, correlational study was to understand the role of transformational leadership in relation to well-being among globally educated nurses (GENs) and contiguous United States, or mainland, educated nurses (CONUS-educated nurses). As internal and external pressures on healthcare systems intensify and impact the workforce, healthcare administrators and leaders must respond. This response must support elements of nurse well-being for both GENs and CONUS-educated nurses. The theoretical framework guiding this study was Transformational Leadership. This quantitative, correlational research design analyzed archival organizational engagement data from two acute care hospitals in New York State. The study examined professional satisfaction, …

Indications, Techniques, And Safety Of Cryotherapy And Cryobiopsy Via Flexible Bronchoscopy In Pediatric Patients, Alex J Katz, Haley Haskett, Kubra M Bozkanat, Aoife Corcoran, Lauren M C Grant, Antoinette Wannes Daou, Sin Tran, Esra Caylan, Alfin Vicencio, Dan T Benscoter, Cherie A Torres-Silva, Sara M Zak, Gregory Burg, Lisa R Young, Pelton Phinizy, Shailendra Das, Richard Paul Boesch, Erik B Hysinger, Joseph Piccione

Faculty, Staff and Students Publications

Rationale: Cryotherapy and its diagnostic analogue, cryobiopsy, are emerging techniques via bronchoscopy with a wide range of clinical applications. While the use of cryotherapy and cryobiopsy has been established in adult pulmonary medicine, pediatric data describing the indications, procedural specifics, outcomes, and complications are limited.

Objective: To describe the indications, procedural specifics, outcomes, and complications of cryotherapy and cryobiopsy use in pediatric bronchoscopy.

Methods: A multicenter retrospective observational study was conducted at 5 pediatric hospitals in the United States. Patients aged 0 to 21 years who underwent cryotherapy or cryobiopsy via bronchoscopy between January 2017 and January 2025 were included. …

Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.

Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …

Perceived Negative Acts And Emotional Well-Being In Healthcare Education At A Hispanic-Serving Institution: A Cross-Sectional Study, Deborah Rocha Seixas, Patricia Montemayor Garcia, Tyreen Heybeck, Eduardo Sanches Gonçales, Cláudia Cristina Biguetti

School of Podiatric Medicine Publications

Purpose: Negative acts (NA), including work-related bullying, person-related bullying, and physical intimidation, are inappropriate behaviors that should not occur in workplaces or schools. Healthcare students may be exposed to these experiences during their training, although exposure may vary across demographics. This study aimed to assess self-reported NA and the emotional well-being among healthcare students from different family immigration backgrounds at a Hispanic-serving institution on the U.S.–Mexico border and to explore potential associations between NA exposure and demographic characteristics. Methods: The NA Questionnaire-Revised (NAQ-R) assessed work-related bullying (WB), person-related bullying (PB), physical intimidation (PI), and total NAQ-R score (TNAQ-R). Participants also …

Impact Of Prematurity On Nutrient Signaling And Protein Synthesis In Skeletal Muscle, Antonio C Ramos Dos Santos, Ki Beom Jang, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Preterm birth disrupts nutrient-responsive signaling pathways critical for skeletal muscle growth and long-term metabolic health. Despite improvements in neonatal care, preterm infants often experience postnatal growth failure marked by impaired lean mass accretion. This review examines how prematurity intrinsically alters insulin and amino acid signaling to mechanistic target of rapamycin complex 1 (mTORC1), a central regulator of translation initiation and protein synthesis. Evidence from translational models reveals blunted activation of mTORC1 and its downstream effectors, independent of birth weight or comorbidities. Defects in insulin-PDK1/mTORC2-Akt signaling and amino acid sensing, particularly leucine sensing, contribute to impaired mTORC1-dependent translation initiation and reduced …

Ixazomib With Chemotherapy For Childhood Relapsed Acute Lymphoblastic Leukemia: A Tacl Consortium Report, Eric S Schafer, Holly L Pacenta, Yueh-Yun Chi, Jemily Malvar, Andrew Doan, Reuven J Schore, Teresa Rushing, Roy Leong, Sean Bujarski, Paul S Gaynon, Seth E Karol, Julio C Barredo, Susan R Rheingold, Van Huynh, Nathan P Gossai, Bill H Chang, Tamra Slone, Melinda Pauly, Alan S Wayne, Deepa Bhojwani, Terzah M Horton

Faculty, Staff and Students Publications

Ixazomib (MLN 9708) is an oral proteasome inhibitor, preclinically more potent than bortezomib, that is currently US Food and Drug Administration–approved for the treatment of multiple myeloma. We conducted a phase 1/2 study to estimate the maximum tolerated dose, recommended phase 2 dose (RP2D), and early efficacy of ixazomib when combined with chemotherapy in pediatric patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). Patients aged ≤21 years with R/R ALL/LL (including Down syndrome) were eligible. Ixazomib was combined with up to 3 different 28-day blocks of well-established, relapsed ALL chemotherapy. Ixazomib was tested at 2 dose …

Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia

Faculty, Staff and Students Publications

No abstract provided.

Cost-Effectiveness Of Hes V2.0 And Galad For Hepatocellular Carcinoma Surveillance In Patients With Cirrhosis, Mert Sahinkoc, Gizem S Nemutlu, Hashem B El-Serag, Mary Linton B Peters, Ali Hajjar, Anthony E Samir, Leigh Anne Dageforde, Fasiha Kanwal, Jagpreet Chhatwal

Faculty, Staff and Students Publications

Background: Ultrasound-based surveillance for HCC is limited by suboptimal sensitivity and low adherence. Blood-based biomarkers are potential alternatives for routine HCC surveillance. We aimed to define optimal sensitivity, specificity, and cost parameters under which blood-based biomarkers could serve as cost-effective alternatives in patients with cirrhosis.

Methods: We developed a microsimulation model of the natural history of HCC in individuals with compensated cirrhosis. We compared the cost-effectiveness of biannual surveillance using 2 blood-based biomarkers-HES V2.0 and GALAD-versus ultrasound-based surveillance across a range of sensitivity, specificity, test costs, and adherence levels. Outcomes included quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios …

Collegiate Athletes’ And Coaches’ Communicative Constitution Of Resilience: A Case Study, Lillian B. Feder

College of Communication Faculty Research and Publications

Resilience processes are communicative in nature and vital to the wellbeing and success of athletic personnel and organizations. However, the communicative components of resilience-building are largely ignored in sport scholarship and practice. This study seeks to bridge that gap by using the communication theory of resilience as a sensitizing concept to develop a thorough understanding of communicative resilience-building processes in athletics. Semi-structured in-depth interviews with members of a Division I college baseball team were analyzed using thematic co-occurrence analysis. Findings indicate that collegiate athletes and coaches experience resilience-building as a combination of mental toughness (i.e., persistence and discipline) and resourcefulness …

De-Centering And Re-Centering Digital Scholarship, Ten Years On, Matthew Hunter, Aaron Retteen, Micah Vandegrift

Faculty Scholarship

Ten years after the publication of a manifesto attempting to describe what digital scholarship could do for and within libraries, some of the original authors reflect on the progress of the call-to-action. This article describes areas in which the integration of digital scholarship activities as core parts of librarianship has and has not become commonplace and traces larger-scale developments in the academy and global knowledge landscape that have contributed to the accuracy of the predictions made in 2017.

Trademarks, Functionality, And Competition, Glynn Lunney

Faculty Scholarship

Courts and commentators have long thought that the purpose of trademark and unfair competition law is to distinguish fair competition from unfair competition and prohibit the latter. Yet, trademark law has a more fundamental, more foundational purpose. Before trademark law can distinguish fair competition from unfair competition, there must first be competition. That makes ensuring competition trademark law’s highest priority. Identifying and prohibiting unfair competition becomes, by necessity, a subordinate concern. Until 1982, courts recognized this hierarchy and enforced a broad and flexible functionality limitation on trademark or trade dress protection to ensure competitive markets. In 1982, however, this changed. …

Law Enforcement With Rent Dissipation, Murat C. Mungan, J. Shahar Dillbary

Faculty Scholarship

We consider a framework which brings together losses arising from rent-dissipation and the workhorse model of law enforcement. Governmental actors engage in a contest to share the proceeds from the enforcement of the law through monetary fines, which leads to rent-dissipation. This causes monetary sanctions to be costly, rendering the model used for studying nonmonetary sanctions a better fit for their analysis. The effect of rent-dissipation on optimal sanctions is directly related to the sanction elasticity of offenses measured at the classic optimum (i.e., where the expected sanction equals the direct harm from the offense). When offenses are inelastic, the …

Constitutional Drafting Processes And Constitutional Success, Adam Chilton, Murat C. Mungan, Mila Versteeg

Faculty Scholarship

Several recent constitution-making processes have been celebrated for being participatory, inclusive, and representative. However, many of these processes also failed. We theorize that aspects of these kinds of constitutional drafting processes could reduce the probability of constitutional success. To show why, we construct a “Constitution Drafting game” (CD game) in which representatives from different interest groups must draft a constitution. We consider the case where the probability of constitutional success is single peaked, but the value from successful adoption is increasing in the degree of issue protection chosen. The drafting process then leads to protection choices that are above those …