Digital Commons Network^™

Editorial: The Journal Of Pediatric Psychology Remains Committed To Advancing Pediatric Psychology Science, Avani C Modi, Kurt A Freeman, Cecelia Valrie, Marisa E Hilliard, Eleanor R Mackey, Katie A Devine, Susan Wood

Faculty, Staff and Students Publications

No abstract provided.

Testing For Bleeding Disorders In Child Abuse: Aap Recommendation Adherence And Testing Results, Lyndsey Hultman, Angela Doswell, Henry T Puls, Shannon L Carpenter, Angela Bachim, Caitlin R Mcnamara, Farah W Brink, Lori D Frasier, Nancy S Harper, Natalie Laub, Kristine A Campbell, Daniel M Lindberg, Joanne N Wood, James Anderst

Faculty, Staff and Students Publications

Objectives: Using a multicenter child abuse pediatrics research network (CAPNET), the study objectives were to characterize the adherence to American Academy of Pediatrics (AAP) recommendations for bleeding disorder testing and the frequency of bleeding disorder identification.

Methods: We performed a descriptive study of bleeding disorder evaluations among children younger than 10 years of age who presented with bruising and/or intracranial hemorrhage (ICH) concerning for abuse from February 2021-May 2022 utilizing CAPNET. Cases were classified as bruising without ICH or ICH with or without bruising. Based on AAP guidance, testing was not recommended in cases with concomitant suspicious injuries, inflicted injury …

Cdc’S Core Elements To Promote Diagnostic Excellence, Daniel J Morgan, Hardeep Singh, Arjun Srinivasan, Andrea Bradford, L Clifford Mcdonald, Preeta K Kutty

Faculty, Staff and Students Publications

Nearly a decade after the National Academy of Medicine released the "Improving Diagnosis in Health Care" report, diagnostic errors remain common, often leading to physical, psychological, emotional, and financial harm. Despite a robust body of research on potential solutions and next steps, the translation of these efforts to patient care has been limited. Improvement initiatives are still narrowly focused on selective themes such as diagnostic stewardship, preventing overdiagnosis, and enhancing clinical reasoning without comprehensively addressing vulnerable systems and processes surrounding diagnosis. To close this implementation gap, the US Centers for Disease Control and Prevention (CDC) released the Core Elements of …

Differentiating Pathology Of Acute Disseminated Encephalomyelitis From Multiple Sclerosis In Children Using Diffusion Magnetic Resonance Biomarkers, Esra Pehlivan, Martin Kinuthia Mwangi, Vihas Abraham, Urmi Mange, Sheng-Kwei Song, Peng Sun, Soe Soe Mar

2020-Current year OA Pubs

BACKGROUND: To investigate the pathologic differences in patients with pediatric-onset multiple sclerosis (POMS) and acute disseminated encephalomyelitis (ADEM) using diffusion tensor imaging (DTI) and diffusion basis spectrum imaging (DBSI).

METHODS: Fifteen children with POMS and eight children with ADEM underwent DTI and DBSI. The comparison of DTI and DBSI diffusivity measures of POMS (31 scans) and ADEM (17 scans) was performed as group comparison and association over time.

RESULTS: In univariate analysis of average measures of DBSI and DTI over time, DBSI fractional anisotropy is lower in POMS than ADEM (P = 0.002), indicative of axonal injury of POMS. Higher …

Fpl Reconstruction After Rupture Following Volar Plate Fixation Of Distal Radius Fractures: A Case Series, Arakua N Welbeck, Brendan J Navarro, Ndéye F Guissé, Charles A Goldfarb, Ryan P Calfee, Christopher J Dy

2020-Current year OA Pubs

PURPOSE: Volar locking plate (VLP) of distal radius fractures (DRF) carries a number of surgical risks including flexor pollicis longus (FPL) rupture secondary to irritation from prominent hardware. This study reviews FPL reconstruction (with interposition graft or tendon transfer) after VLP-related rupture.

METHODS: This retrospective case series reports the experience at one tertiary center with FPL reconstruction after DRF. Patients treated between January 1, 2013, and June 12, 2023, were eligible for inclusion. Preoperative radiographs were analyzed for Soong grading and fracture reduction parameters. Accessible patients (n = 7) were examined to evaluate long-term success of reconstruction.

RESULTS: Fifteen patients …

Sensitivity Of Lung Point-Of-Care Ultrasound (Pocus) To Predict Oxygen Requirements In Emerging Viral Infections, Daniel L Theodoro, Di Coneybeare, Penelope Lema, Nicholas Renz, Laura Wallace, Enyo Ablordeppey, Sean Stickles, Alek Rosenthal, Ian Holley, Sirivalli Chamarti, Josie Acuña, James Patterson, Rachel Ancona, Srikar Adhikari

2020-Current year OA Pubs

OBJECTIVES: The prognostic characteristics of lung point-of-care ultrasound (L-POCUS) to predict respiratory decompensation in patients with emerging infections remains unstudied. Our objective was to examine whether scored lung ultrasounds predict hypoxia among a nonhypoxic, ambulatory population of patients with COVID-19.

METHODS: This was a diagnostic case-control study. Three academic emergency departments across the United States collected a convenience sample of nonhypoxic subjects with COVID-19, scored subjects' hemithorax at 7 locations using lung ultrasound, and followed outcomes for 40 days. We defined cases as hypoxia (≤91% by pulse oxygenation) from 2 hours after index presentation to day 40. Follow-up was by …

An Asymmetric Nautilus-Like Hflk/C Assembly Controls Ftsh Proteolysis Of Membrane Proteins, Alireza Ghanbarpour, Bertina Telusma, Barrett M Powell, Jia Jia Zhang, Isabella Bolstad, Carolyn Vargas, Sandro Keller, Tania A Baker, Robert T Sauer, Joseph H Davis

2020-Current year OA Pubs

The AAA protease FtsH associates with HflK/C subunits to form a megadalton-size complex that spans the inner membrane and extends into the periplasm of E. coli. How this bacterial complex and homologous assemblies in eukaryotic organelles recruit, extract, and degrade membrane-embedded substrates is unclear. Following the overproduction of protein components, recent cryo-EM structures showed symmetric HflK/C cages surrounding FtsH in a manner proposed to inhibit the degradation of membrane-embedded substrates. Here, we present structures of native protein complexes, in which HflK/C instead forms an asymmetric nautilus-shaped assembly with an entryway for membrane-embedded substrates to reach and be engaged by FtsH. …

For Girls And Women (4gw) Hpv Rct Protocol: A Crowdsourced, Pragmatic Stepped-Wedge Cluster Randomized Trial To Improve Uptake Of Hpv Vaccination And Screening Among Mother-Daughter Dyads In Nigeria, Juliet Iwelunmor, Ekenechukwu Kokelu, Temitope Ojo, Olufunto Olusanya, Titilola Gbaja-Biamila, Peter Kalulu, Angel Obiorah, Maria Afadapa, Nkiruka Obodoechina, Onyeka Anikamadu, Et Al.

2020-Current year OA Pubs

BACKGROUND: Expanding human papillomavirus (HPV) vaccination for girls and HPV self-collection for women can reduce the global burden of cervical cancer. However, HPV vaccination and self-collection services are rarely implemented simultaneously in mother-daughter dyads, leaving a critical gap in cervical cancer prevention. From 2023 to 2024, a community-engaged model for combined HPV vaccination and screening was co-designed using crowdsourcing open calls and designathons with mother-daughter teams and pilot-tested by trained research facilitators. This study explores the impact of this crowdsourced, community-engaged mother-daughter campaign and implementation strategy bundle on HPV vaccination among girls and HPV screening among their mothers in Nigeria …

Plasma P-Tau217 And Tau-Pet Predict Future Cognitive Decline Among Cognitively Unimpaired Individuals: Implications For Clinical Trials, Rik Ossenkoppele, Tammie L S Benzinger, Suzanne E Schindler, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal display similar associations with cognitive decline on a global cognitive composite test (R

Longitudinal Profiling Of Low-Abundance Strains In Microbiomes With Chronostrain, Younhun Kim, Colin J Worby, Sawal Acharya, Lucas R Van Dijk, Daniel Alfonsetti, Zackary Gromko, Philippe N Azimzadeh, Karen W Dodson, Georg K Gerber, Scott J Hultgren, Ashlee M Earl, Bonnie Berger, Travis E Gibson

2020-Current year OA Pubs

The ability to detect and quantify microbiota over time from shotgun metagenomic data has a plethora of clinical, basic science and public health applications. Given these applications, and the observation that pathogens and other taxa of interest can reside at low relative abundance, there is a critical need for algorithms that accurately profile low-abundance microbial taxa with strain-level resolution. Here we present ChronoStrain: a sequence quality- and time-aware Bayesian model for profiling strains in longitudinal samples. ChronoStrain explicitly models the presence or absence of each strain and produces a probability distribution over abundance trajectories for each strain. Using synthetic and …

The Victorian Institute Of Sport Assessment – Achilles Is Fundamentally Flawed And Unfit For Clinical Practice Or Research: A Rasch Measurement Theory Analysis Using Cosmin Recommendations, Nigel Travers, Myles C. Murphy, Benedict M. Wand, Paul Kirwan, Mervyn Travers, James Debenham, William Gibson, Dana Hince

Research outputs 2022 to 2026

Objectives: Evaluate structural validity, hypothesis testing and measurement invariance of the Victorian Institute of Sport Assessment–Achilles (VISA-A) using Rasch analysis to determine if it can be recommended to measure Achilles tendinopathy severity. Methods: We performed an evaluation of the VISA-A measurement properties using Rasch Measurement Theory by pooling individual participant data from previously conducted studies (n = 217). Structural validity was assessed via threshold/category mean order; adequate item fit; unidimensionality; local dependence; internal consistency. Hypothesis testing was assessed via divergent validity. Measurement invariance assessed via differential item functioning. Results: The VISA-A has inadequate construct validity. This is evident from issues …

Transformative Learning In Homebirth Settings: A Reflexive Thematic Analysis Of Midwifery Students' Experiences, Kate Buchanan, Sara Morris, Sara Bayes, Clare Davison

Research outputs 2022 to 2026

Background: The homebirth setting provides opportunities for midwifery students to witness autonomous midwifery practice, but these experiences are limited. Factors that limit practicum placement in the home birth setting are either logistical, with less than one percent of women having a homebirth in Australia or related to university governance, whereby approval is not granted for midwifery students attending homebirth. Objectives: To explore midwifery students' experiences in the homebirth setting and to determine how this has influenced understandings of the role and scope of practice the midwife. Methods: Qualitative methods were chosen to inform this study. Setting: A University that offers …

Excess Weight Is Associated With Neurological And Neuropsychiatric Symptoms In Post-Covid-19 Condition: A Systematic Review And Meta-Analysis, Débora Barbosa Ronca, Larissa Otaviano Mesquita, Dryelle Oliveira, Ana Cláudia Morais Godoy Figueiredo, Jun Wen, Manshu Song, Kênia Mara Baiocchi De Carvalho

Research outputs 2022 to 2026

Background/purpose Excess weight has been identified as a potential risk factor for post-COVID-19 condition (PCC). This systematic review and meta-analysis aimed to investigate whether excess weight is associated with the development or experience of neurological and neuropsychiatric symptoms in PCC. Methods We conducted a comprehensive search of eight databases (PubMed, Embase, Scopus, Web of Science, VHL, Google Scholar, ProQuest, and medRxiv) for studies published up to July 2023. Studies were included if they assessed PCC symptoms in relation to nutritional status, specifically the development of neurological and neuropsychiatric symptoms more than 12 weeks post-infection. The analysis compared exposure and controls …

Navigating Travel Therapy: Balancing Benefits And Risks For Optimal Wellness, Fangli Hu, Jun Wen, Wei Wang

Research outputs 2022 to 2026

This research note examines travel therapy as a novel healthcare approach in which positive travel experiences serve to promote well-being. It emphasizes the need for a balanced assessment of the benefits and risks associated with travel therapy, offering insights into this practice's evolving roles in the health and wellness domains.

Ecological Specialisation Of Reef Fishes Peaks In Global Biodiversity Hotspots, Zoé Delecambre, Renato A. Morais, Alexandre C. Siqueira, Emma Paul Costesec, Caroline E. Dubé, Sergio R. Floeter, Alan M. Friedlander, Fabien Leprieur, Yves Letourneur, Lucas T. Nunes, Jordan M. Casey, Valeriano Parravicini

Research outputs 2022 to 2026

Aim: The role of ecological specialisation in shaping biogeographic and evolutionary patterns remains unresolved. To date, few studies have quantitatively examined consumer niche breadth at a global scale. We describe global biogeographic and diversification patterns of specialisation, measured using trophic and thermal niches, for a highly diverse assemblage of consumers: reef fishes. First, we investigated the confluence of specialisation with global biogeographic patterns in species richness and reef area. Then, we tested whether these patterns could be explained by differences in diversification rates and geographic ranges. Location: Tropical reefs across the globe. Time Period: Present. Major Taxa Studied: Reef fishes. …

A Multivariate Analysis Of Reported Quality Of Life Among Medical Students In Jordan Using The Whoqol-Bref, Mohammad Hamad, Saba Al Smadi, Diana Arabiat

Research outputs 2022 to 2026

BACKGROUND: Low quality of life (QoL) in university students is often associated with unhealthy lifestyle and negative impacts on students' ability to learn and succeed. To date, no research has examined the QoL of medical students in Jordan or the demographic factors that may associate with lower QoL. MATERIALS AND METHODS: A quantitative, cross-sectional study with a descriptive design was chosen for this study. Participants were 512 medical students from one public university in Jordan. The Arabic version of the World Health Quality of life-brief survey (WHOQOL-BREF) was used to collect data online from students. RESULTS: Regarding the overall QoL, …

Indirect Evidence Of Sex-Selective Abortion Practices To The Imbalanced Sex Ratio At Birth In Australian Migrant Populations, Amanuel Tesfay Gebremedhin, Gizachew A. Tessema, Ravisha Srinivasjois, Judith A. Daire, Kevin A. Chai, Bereket Duko, Kalayu Brhane Mruts, Gavin Pereira

Research outputs 2022 to 2026

A skewed sex ratio at birth (SRB), commonly observed in countries with high son preference can be attributed to prenatal sex-selective abortion. However, the possibility of sex selection among migrants in high-income countries has received little attention. Our study aims to identify the indirect evidence of sex-selective abortion practices to the SRB imbalance in a large Australian cohort. Our study aims to identify the indirect evidence of sex-selective abortion practices to the SRB imbalance in a large Australian cohort. In this population-based study, perinatal data were obtained from all registered births in Western Australia (WA) and New South Wales (NSW) …

Networked Multi-Agent Deep Reinforcement Learning Framework For The Provision Of Ancillary Services In Hybrid Power Plants, Muhammad Ikram, Daryoush Habibi, Asma Aziz

Research outputs 2022 to 2026

Inverter-based resources (IBRs) are becoming more prominent due to the increasing penetration of renewable energy sources that reduce power system inertia, compromising power system stability and grid support services. At present, optimal coordination among generation technologies remains a significant challenge for frequency control services. This paper presents a novel networked multi-agent deep reinforcement learning (N—MADRL) scheme for optimal dispatch and frequency control services. First, we develop a model-free environment consisting of a photovoltaic (PV) plant, a wind plant (WP), and an energy storage system (ESS) plant. The proposed framework uses a combination of multi-agent actor-critic (MAAC) and soft actor-critic (SAC) …

Using Natural Language Processing And Machine Learning To Detect Online Radicalisation In The Maldivian Language, Dhivehi, Hussain Ibrahim, Ahmed Ibrahim, Michael N. Johnstone

Research outputs 2022 to 2026

Early detection of online radical content is important for intelligence services to combat radicalisation and terrorism. The motivation for this research was the lack of language tools in the detection of radicalisation in the Maldivian language, Dhivehi. This research applied Machine Learning and Natural Language Processing (NLP) to detect online radicalisation content in Dhivehi, with the incorporation of domain-specific knowledge. The research used Machine Learning to evaluate the most effective technique for detection of radicalisation text in Dhivehi and used interviews with Subject Matter Experts and self-deradicalised individuals to validate the results, add contextual information and improve recognition accuracy. The …

Brand Loyalty And Repurchase Intention In The Face Of Opportunistic Recalls: The Moderating Role Of Perceived Dialogical Csr Communication, Shahid Hussain, Pi Shen Seet, Asim Qazi, Abdul Salam, Saalem Sadeque, Sanaullah Shar

Research outputs 2022 to 2026

Product recalls, particularly when perceived as opportunistic, can trigger severe consumer backlash, undermining brand loyalty and escalating protest behaviors that threaten long-term consumer-brand relationships. This study integrates expectancy violation theory and situational crisis communication theory to understand the implications of opportunistic recalls for brand loyalty and repurchase intention. A survey with 425 responses from car owners in the United States was analyzed using partial least squares structural equation modelling (PLS-SEM). It found that opportunistic recalls significantly exacerbate negative brand personality and directly influence protest behavior and brand loyalty. A counterintuitive finding emerges with protest behavior positively impacting brand loyalty, an …

Refractive Error And Axial Length (Real) Study: Feasibility Of A Population Study In The United States, Sarah E. Singh Dr, Lisa A. Ostrin, Kristen Kerber Dr, Concepcion Cayle, Celia Gong Dr, Lal Barsha Dr, Ian Flitcroft, Síofra Harrington, James Loughman, Kathryn Saunders Prof, Fuensanta Vera-Diaz Dr

Articles

Myopia is the most common eye disease and a leading cause of blindness. A contemporary, large, and ethnically and geographically diverse study of ocular biometry and refractive error in children in the United States is needed to help better describe differences between myopic and nonmyopic eyes.

This is an initial cross-sectional report from the Refractive Error and Axial Length Growth Curve Study that includes ocular component data as a function of age, gender, and geographic location. This feasibility report will inform a planned larger longitudinal ocular growth study in children in the United States.

Cross-sectional data on children, ages 3 …

Simulation-Guided Pan-Cancer Analysis Identifies A Novel Regulator Of Cpg Island Hypermethylation Heterogeneity, Xianglin Zhang, Wei Zhang, Jinyi Zhang, Xiuhong Lyu, Haoran Pan, Tianwei Jia, Ting Wang, Xiaowo Wang, Haiyang Guo

2020-Current year OA Pubs

CpG island hypermethylation, a hallmark of cancer, exhibits substantial heterogeneity across tumors, presenting both opportunities and challenges for cancer diagnostics and therapeutics. While this heterogeneity offers potential for patient stratification to predict clinical outcomes and personalize treatments, it complicates the development of robust biomarkers for early detection. Understanding the mechanisms driving this heterogeneity is essential for advancing biomarker design. Here, simulation-based analyses demonstrate that tumor purity and the high prevalence of low epi-mutation samples significantly obscure the identification of negative, rather than positive, regulators of CpG island hypermethylation, limiting a comprehensive understanding of heterogeneity sources. By addressing these confounders, we …

Atypical Presentation Of Iars1-Related Disorder: Expanding The Phenotype And Genotype, Parith Wongkittichote, Kira E Jonatzke, Benjamin T Hyde, Lance W Peterson, Mai He, Robert C Mckinstry, Anthony Antonellis, Marwan Shinawi

2020-Current year OA Pubs

Aminoacyl-tRNA synthetases (ARSs) catalyze the formation of aminoacyl-tRNA, which is required for protein translation. A growing number of cases are associated with ARS deficiencies. Pathogenic variants in

Vascular Rings - What Has Changed, And What Do I Need To Know As A Practitioner?, Sarah Madira, William B Orr, Joshua M Rosenblum, Ryan Pitman, Quang-Tuyen Nguyen, David Molter, Ashley Lloyd, Julie Glickstein, Markus Renno, Pirooz Eghtesady, Jacob R Miller

2020-Current year OA Pubs

Vascular rings represent a heterogeneous set of aberrant great vessel anatomic configurations which can cause respiratory symptoms or dysphagia due to tracheal or oesophageal compression. These symptoms can be subtle and may present at varied ages. More recently, many have been identified in patients without symptoms, including fetal echocardiogram, resulting in a conundrum for practitioners when attempting to determine who will benefit from surgical correction. Here, we provide a review of vascular rings and a guide to the practitioner on when to consider additional imaging or referral. Additionally, we discuss the changing landscape regarding asymptomatic patients and fetal echocardiogram.

Global Guideline For The Diagnosis And Management Of Candidiasis: An Initiative Of The Ecmm In Cooperation With Isham And Asm, Oliver A. Cornely, Andrej Spec, Et Al.

2020-Current year OA Pubs

No abstract provided.

Trends In Urology Residency Applications: Results From The American Urological Association Medical Student Survey From 2022 To 2024, Michael Creswell, Kirsten Greene, Lee Richstone, Simone Thavaseelan, Erica Traxel, Aaron Tverye, Casey Kowalik, Gina Badalato, Thomas Jarrett, Kate Kraft, Mathew Sorensen, Moben Mirza

2020-Current year OA Pubs

OBJECTIVE: To provide a comprehensive overview of the American Urological Association Medical Student Surveys and includes data 2022, 2023, and 2024.

METHODS: Data collected through surveys distributed prior to match day and were distributed to all medical students who submitted a rank list for urology residency. Questions consisted of various topics, including applicant demographics, application metrics, and experiences with preference signals and virtual interviews.

RESULTS: 440 (79%), 428 (84%), and 387 (77%) applicants participated in surveys for the years 2022, 2023, and 2024, respectively. Applicants continue to participate in research at a high level. Additionally, United States Medical Licensing Exam …

Kinetic Growth Rate Analysis Of Coelastrella Sp. In Aquaculture Wastewater., Rob Skarvan

Master of Engineering Theses

The demand for sustainable food and energy production continues to rapidly rise. Utilizing aquaculture wastewater as microalgae growth medium is a potential opportunity for nutrient recycling and industrial symbiosis, but more research is required to understand how best to design and scale-up a dual-purpose facility. This study investigates the growth of Coelastrella sp. in aquaculture wastewater compared to industry-standard growth medium BG-11 and modified tap water as controls. Though cell size and pigment density varied throughout media, aquaculture wastewater performed very comparably to BG-11 as a microalgae culture broth.

The Monod equation can model Coelastrella sp. growth based …

Minimizing Secondary Spinal Cord Injuries With Hypertonic Saline., Francisco A. Cortez-Thomas

Master of Engineering Theses

Spinal cord injury (SCI) disrupts white matter, causing periaxonal swelling, axonal degeneration, and impaired function. To examine vascular edema’s role, we developed a 3Dprinted dual-compartment imaging chamber to mimic and manipulate interstitial and vascular fluid dynamics in real time. We hypothesized that hypertonic saline (HTS) in the "vascular" chamber would osmotically shift fluid from the periaxonal space and preserve myelinated fibers after SCI. Using two-photon excitation microscopy, we imaged myelin and axons ex vivo in Thy1^YFP+ transgenic mice following C5 contusive SCI and assessed three clinically relevant HTS concentrations versus normal saline for their effectiveness in mitigating periaxonal swelling …

Commutative Rings, Vilmaris Alvarado

Harriet L Wilkes Honors College Theses

A group ring, R[G], is the set of all elements of G together with a coefficient from R. Elements of group rings are classified similarly to rings. For example, an element, x, is classified as a unit if there exists another element, y, such that xy produces the multiplicative identity. In the integers, 1 is the trivial unit. Due to the variably large sizes of group rings, using excel sheets often allows for easier computation of group elements and multiplication.

A Co-Design Approach To Develop A Motivational Intervention To Promote Physical Activity Engagement And Maintenance Among Individuals In Residential Substance Use Disorder Treatment Settings, Sascha Thal, Stephen Bright, Nikos Ntoumanis, Bronwyn Myers, Jocelyn Jones, Eleanor Quested

Research outputs 2022 to 2026

Substance use disorders (SUDs) pose a significant public health concern. Preliminary research suggests benefits of physical activity (PA) for individuals receiving SUD treatment. However, current PA interventions have limitations, particularly regarding PA maintenance, due to motivational issues among people with SUDs. Our co-designed intervention is the first to target PA motivation for sustaining PA in individuals with SUDs. We employed the Behaviour Change Wheel (BCW) to co-design an intervention to increase PA motivation and support PA maintenance among people in residential SUD treatment. The BCW process involved semi-structured interviews with people with lived or living experience (n = 5) and …