Digital Commons Network^™

Development Of Saddlepoint Methodologies For Sparse Sample Multiple Parameter Generalized Linear Models And Correlated Data Scenarios, Christopher Johnson

All Graduate Theses and Dissertations, Fall 2023 to Present

Parameter estimation using maximum likelihood techniques may be biased when sample sizes are small, event rates are low, or otherwise sparse counts exist in a parametric model. This in turn may lead researchers to draw invalid statistical conclusions when conventional methods are utilized. The saddlepoint approximation has potential to lessen the degree of bias in sparse data conditions through its use of moments beyond the mean and variance, which allows for more accurate approximations using a smaller number of observations. We propose two novel saddlepoint methods for use in practical analysis scenarios, as an alternative to maximum likelihood estimation. First, …

Forging Resilient Futures: The Role Of Community Organizations In Addressing Environmental Injustices Faced By Immigrants Along The Wasatch Front, Utah, Nowrin Fatema

All Graduate Theses and Dissertations, Fall 2023 to Present

Utah’s Wasatch Front is an urban area with a growing population that faces looming environmental challenges, such as the desiccation of the Great Salt Lake, worsening air quality, water scarcity, and the impacts of urban sprawl. If not prevented, the lake’s desiccation or other environmental challenges could result in dangerous air pollution, biodiversity loss, and disruptions to local economies. Immigrant populations may be uniquely vulnerable to these environmental changes because of economic, social, and political marginalization. For example, 50% of Salt Lake City’s foreign-born residents live on the City’s westside—the area on the frontline of the lake’s toxic dust. My …

Gone With The Flow: Flow Reduction Coincides With Reduced Metabolism And Standing Stock Of Benthic Algae And Macroinvertebrates In Desert Rivers, Chloe E. Lyles

All Graduate Theses and Dissertations, Fall 2023 to Present

River metabolism, the measure of energy flow in a river, is driven by hydrological and physicochemical regimes (e.g., temperature, turbidity, and nutrients). However, these regimes are increasingly altered by human water demand and climate change-driven drought. These stressors alter the magnitude, timing, and duration of critical spring-snowmelt floods with poorly understood consequences on ecosystem function, particularly in desert rivers. To investigate the linkages between flow reduction, river metabolism, and basal food resource productivity (i.e., algae and aquatic invertebrates), we measured metabolism and basal resource availability in seven desert tributaries with varying degrees of flow reduction during low-flow conditions in 2023 …

Learning Intentions, Success Criteria, And Metacognition: The Influence Of A Professional Development For Grades Three To Five Teachers, Jason Hart

All Graduate Theses and Dissertations, Fall 2023 to Present

Formative assessment is a strategy that teachers use to improve student learning. This study explored how professional development focused on assessment for learning practices (AFL), with the main emphasis on learning intentions and success criteria, influences teacher use of those strategies and changes in teacher and student metacognition. The overarching research question was: How does professional development on AFL practices influence teachers' reported use of AFL practices and teacher and student metacognition? This study utilized a mixes-methods research design and provided professional development on AFL practices to 16 in-service elementary mathematics teachers and measured changes to their AFL practices and …

Digital Twins, Synthetic Patient Data, And In-Silico Trials: Can They Empower Paediatric Clinical Trials?, Mohan Pammi, Prakesh S Shah, Liu K Yang, Joseph Hagan, Nima Aghaeepour, Josef Neu

Faculty, Staff and Students Publications

Randomised controlled trials are the gold standard to assess the effectiveness and safety of clinical interventions; however, many paediatric trials are discontinued early due to challenges in patient enrolment. Hence, most paediatric clinical trials suffer from lack of adequate power. Additionally, trials are expensive and might expose patients to unproven therapies. Alternatives to overcome these issues using virtual patient data—namely, digital twins, synthetic patient data, and in-silico trials—are now possible due to rapid advances in digital health-care tools and interventions. However, such digital innovations have been rarely used in paediatric trials. In this Viewpoint, we propose using virtual patient data …

Irrigation Performance Connection To Water Quality In Big Creek, Sena Bildim

All Graduate Theses and Dissertations, Fall 2023 to Present

Due to new technologies and improved water management strategies, sprinkler irrigation systems are becoming more common in Utah and nearby areas. These systems are generally thought to be more efficient, but their effects on water quality are not well understood. This study focuses on the Big Creek watershed, which flows into Bear Lake—an area where water quality concerns are increasing.

The purpose of this research was to explore how different irrigation systems—sprinkler and surface—affect both water use and water quality. Field tests were conducted to measure how evenly water was applied and how efficient each system was. Water and soil …

Understanding The Impact Of Colloidal Calcium Phosphate On The Ph Variation In Cheddar Cheese During Early Stages Of Aging, Rachel Lindstrom

All Graduate Theses and Dissertations, Fall 2023 to Present

The Cheddar cheese industry has recently observed variation in the pH of their cheese during the early stage of storage. This variation may be due to the addition of the faster acid producing thermophilic starter culture Streptococcus thermophilus which was recently introduced into the Cheddar cheese making process. This starter culture may impact the calcium buffering properties of the cheese due to more retention of the insoluble calcium (INSOL Ca) within the cheese. To investigate this problem, we studied how insoluble calcium affects cheeses with pH ranging from 4.8 to 6.6 and found that INSOL Ca was positively correlated with …

High-Throughput Phenotyping Of Early Generation Small Grains Breeding Lines To Indirectly Select For Grain Yield, Dalton Jones

All Graduate Theses and Dissertations, Fall 2023 to Present

In small grains breeding programs, breeders aim to develop better varieties by selecting for important traits like grain yield. However, it takes many years before yield can be measured because several generations of selection are required to fix lines and increase sufficient seed for yield measurements. This process can be slow and expensive

High-throughput phenotyping (HTP) is a modern approach that can increase breeding efficiency by leveraging technology to quickly measure secondary traits which can be used to indirectly select for important traits in crop plants. For example, researchers can use cameras on unmanned aerial vehicles (UAVs, i.e., drones) to …

Game Changing Education: Empowering High School Stem Teachers To Teach Engineering Using Games, Leslie Brown

All Graduate Theses and Dissertations, Fall 2023 to Present

In response to the Next Generation Science Standards (NGSS) released in 2013, there was a nationwide push for K-12 schools to include engineering concepts in science classrooms. However, there is an overall lack of teacher preparedness and training towards engineering topics as shown by common engineering misconceptions. To improve this issue, I initiated a qualitative study to describe the strategies and attitudes of high school science, technology, engineering, and mathematics (STEM) teachers that have implemented game-based, engineering activities into their classroom. Game-based learning is an instructional framework that utilizes game-like elements in a classroom and was used in this study …

Strategies For Increasing Methane Removal In Methanotroph Bench-Scale Systems For The Production Of Ectoine, Jaden Storrer

All Graduate Theses and Dissertations, Fall 2023 to Present

Anthropogenic methane emissions contribute to the greenhouse gas profile which is the chief cause of climate change. One significant source of methane emissions is biogas produced from bacteria in wastewater facilities and landfills. Methane rich biogas has the potential to be valorized into high value bioproducts by using methanotrophs (microbes that use methane as their primary carbon source). Methylotuvimicrobium alcaliphilum 20Z was selected for this study as it can generate ectoine when grown in highly saline environments. Ectoine has been proven to have many benefits such as it prevents protein denaturation, it has hydration properties, and is a UV protectant. …

Caregiver Mand Training: Evaluating The Effects Of Using Bug-In-Ear Coaching Via Telehealth, Makenna P. Carnesecca

All Graduate Theses and Dissertations, Fall 2023 to Present

Applied Behavior Analysis has been seen to be an effective way to help teach skills to children with autism. Caregivers' involvement in teaching these skills is beneficial for their child's progress. Using Bug-in-Ear coaching, which provides in-the-moment instructions and feedback to caregivers via Bluetooth headphones, has been demonstrated to be a potential way to train caregivers to teach skills to their children. This current study aimed to evaluate if the use of Bug-in-Ear coaching via telehealth was an effective way to teach caregivers to train their children how to ask for wanted foods using picture cards. The results of this …

A Model Of Changeover Behavior In Concurrent Schedules Of Reinforcement, Matias A. Avellaneda

All Graduate Theses and Dissertations, Fall 2023 to Present

Animals in the wild have access to a variety of food sources, and they must allocate their time between them in an efficient manner. This requires deciding when to depart from the source currently being exploited to travel to a different one. A general model of this decision process can be derived from three assumptions well supported by the learning literature. The first one is the so-called matching law, which says that the proportion of time allocated to any one behavior equals the proportion of total value obtained from that option. The second one is that the dwell times (i.e., …

Aerobic Biodegradation Of Algae-Derived Bioplastics Under Controlled Composting Conditions, Clayton J. Lords

All Graduate Theses and Dissertations, Fall 2023 to Present

Plastics are versatile polymers that have become critically important materials in many industries. Although plastics are important and useful materials, they account for vast amounts of environmental pollution and climate change contribution. Sustainable bioproducts are becoming increasingly important in the effort to mitigate the impacts of pollution and climate change. The scale of environmental damage caused by plastic pollution highlights the need to implement sustainably sourced biodegradable plastics within the global economy. Bioplastics are materials that may be manufactured from biological materials or can biodegrade under certain conditions. Algae are microorganisms that can be grown using nutrient-rich municipal wastewater; the …

Analyzing Microalgae-Bacteria Population Changes In Response To Environmental Parameters For Improved Wastewater Treatment, Amanda M. Moravek

All Graduate Theses and Dissertations, Fall 2023 to Present

Microalgae are incredible organisms that have a variety of uses such as wastewater treatment, fertilizer, livestock feed, and bio-compound production. Microalgae require a light source and minimal nutrients space to proliferate, making them an environmentally friendly and sustainable option for such processes. The Sustainable Wastes-to-Bioproducts Engineering Center at Utah State University is developing and implementing a Rotating Algae Biofilm Reactor (RABR) to remove total nitrogen and phosphorous from the Central Valley Wastewater Reclamation Facility wastewater effluent. Harmful compounds such as nitrates and phosphates are metabolized by the microalgae and converted into useful bioproducts, resulting in a circular economy. These RABRs …

Influence Of Physical Properties Of Fat On Product Quality, Shelf-Life And Consumer Acceptance Of Chocolate-Coated Products, Audrey Lidgard

All Graduate Theses and Dissertations, Fall 2023 to Present

In chocolate-coated products, oil migration in fats can lead to chocolate softening, filling hardening, discoloration, and lower consumer acceptance. This study examined three different fats (soy- palm-, and palm-kernel (PK) based), crystallized under different conditions (cooling rate and use of high intensity ultrasound (HIU)) to examine how the crystallization conditions impact the physical properties of confectionery products. These conditions produced fats with high and low oil binding capacities (OBCs); the ability of crystal networks to entrap liquid oil. Model systems were created to examine measurable quality degradation and consumer acceptance of chocolates placed in contact with the fats; one with …

Water Use By Irrigated Turfgrass And Connections To Climate And Biophysical Processes, Karem Meza

All Graduate Theses and Dissertations, Fall 2023 to Present

Urbanization and limited water supply and storage result in imbalanced urban water budgets. Quantification of water use becomes important in urban landscapes because urban turfgrass requires a significant amount of water and competes with other urban requirements. Evapotranspiration (ET) plays a crucial role in determining irrigation needs. Credible measurements and spatial estimates of urban turfgrass ET are needed for urban water management. However, these have not been addressed in urban landscapes in arid and semiarid regions. Despite estimating spatial urban turfgrass ET, turfgrass quality linked to ET has not been widely evaluated. Due to different environmental conditions, the driving forces …

Attachment, Emotional Experiencing, And Physiological Response During Couple Interaction, Kyla Iverson

All Graduate Theses and Dissertations, Fall 2023 to Present

In this master’s thesis, I conducted a study using data from 63 hetereosexual couples from a previous research study done by Dr. Ryan Seedall. These couples participated in a micro-intervention where each partner discussed personal issues for three to four minutes while the other received guidance on supportive responses, promoting open communication. Using this data, I conducted a coding project studying the relationship between attachment styles and emotional experiencing, specifically how attachment styles intersect with emotional experiences, moment-to-moment feelings, and physiological arousal. This coding project involved utilizing the Emotional Experiencing Scale (EXP) by Klein and colleagues (1986) to observe couple …

Seeding Rate, Planting Date, And Herbicides For Dormant Seeded Safflower In Utah, Rodney Daniel Nelson

All Graduate Theses and Dissertations, Fall 2023 to Present

Dryland crop production in the Intermountain West is largely limited by the amount of precipitation received. Increasing dryland safflower (Carthamus tinctorius L.) production yields in a semi-arid climate is possible with a dormant planting but is not well understood. A two-year (2020-22) project was designed to gain an understanding of the effects of variety, seeding rate, and planting date, on dormant seeded safflower. Chemical weed control options for safflower were also evaluated. One study, conducted at three Utah State University research farms near Blue Creek, Clarkston, and Kaysville, UT, evaluated four varieties, S-208, S-333, 7325 and Hybrid-446, seeded at …

Effects Of Light Intensity On Algae Biofilms In Rotating Algae Biofilm Reactors (Rabr), Joshua D. Wintch

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a growing need for economically and ecologically friendly wastewater treatment processes. Utilizing natural algae biofilms to remediate excess nitrogen and phosphorus from municipal wastewater is a treatment technique of academic interest. Utilizing natural algae in rotating algae biofilm reactors (RABR) is a potential engineering application of algae biofilms for municipal wastewater anaerobic digestor effluent treatment. The ideal reactor operation would use sunlight as the light source for algae growth, however, there is little academic research on algae biofilm growth productivity across natural sunlight light intensity ranges. This research seeks to understand the relationship between rotating algae biofilm reactor …

Exploring The Utilization Of Benefits And Participation Experiences Among Immigrants And Refugees In Wic Program: A Mixed-Method Study, Melissa Murillo Timoschenco

All Graduate Theses and Dissertations, Fall 2023 to Present

Food insecurity is a critical issue globally and in the United States. The USDA’s Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) aims to address this by improving the nutrition of low-income pregnant women and children. However, immigrants and refugees, who are particularly vulnerable to food insecurity, often encounter barriers to accessing WIC benefits. This study aimed to: i) evaluate how immigrant and refugee families in Utah utilize WIC benefits, and ii) explore their experiences, challenges, and suggestions for improving the program. This mixed-method study combined surveys with 116 participants and in-depth interviews with 25 participants. Surveys were …

Potamogeton Crispus Invasion: Impacts On Native Aquatic Plants And Associated Faunal Habitat, Meghan-Grace Slocombe

All Graduate Theses and Dissertations, Fall 2023 to Present

Aquatic invasive plants are non-native plants that invade a water body and displace native aquatic plants. Invasion depletes the native plant community's ability to provide ecosystem services, including improved water quality, decreased problematic algae, and increased animal habitat. The loss of these ecosystem services reduces the value of fishing, boating, and swimming opportunities in aquatic ecosystems. The potential changes in plant communities and services are particularly important at sites targeted for restoration because project goals typically include increasing ecosystem services, including wildlife habitat. Curly-leaf pondweed (Potamogeton crispus L.) is a problematic invasive species in North America. To better manage …

A Randomized Controlled Trial Of Self-Help Acceptance And Commitment Therapy And Cognitive Behavioral Therapy For Perfectionism, Emily M. Bowers

All Graduate Theses and Dissertations, Fall 2023 to Present

Many college students are struggling with perfectionism, a tendency to set extremely high standards for themselves, which can lead to stress and dissatisfaction. We looked at whether self-help books based on two different types of therapy, acceptance and commitment therapy (ACT) and cognitive behavioral therapy (CBT), can help reduce unhelpful perfectionism. We looked at how well ACT and CBT self-help books worked for reducing perfectionism, compared to students who did not receive either book. College students in the study completed surveys at the beginning, halfway through, after finishing the book, and again one month later. We found that students who …

Designing Accessible And Dependable Tools For Vocational Rehabilitation Data Analysis, Ruth E. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Since 1973, the U.S. Rehabilitation Services Administration (RSA) has partnered with state vocational rehabilitation (VR) agencies to help individuals with disabilities achieve meaningful employment and independence. RSA-911 datasets play a crucial role in this effort by capturing detailed participant data, but their complexity can hinder effective analysis.

To simplify this process, we present an R software package to streamline the cleaning and analysis of RSA-911 and Transition Readiness Toolkit (TRT) data, a new measure of program effectiveness. We also deliver a user-friendly dashboard, empowering both VR researchers and counselors with the opportunity to conduct analyses. Using our developed tools, we …

A Systematic Review Of Acceptance And Commitment Therapy In Sub-Saharan Africa: Understanding The Cultural Adaptations, Miriam N. Mukasa

All Graduate Theses and Dissertations, Fall 2023 to Present

Acceptance and Commitment Therapy (ACT) is a type of therapy that helps people handle difficult thoughts and feelings by staying present, accepting what they cannot control, and focusing on what truly matters to them. Despite its growing global popularity, the implementation and effectiveness of ACT in sub-Saharan Africa remains underexplored.

We evaluated the current evidence on the application, effectiveness, and cultural adaptation of ACT in sub-Saharan Africa, identifying gaps and providing recommendations for future research.

18 unique studies that met the inclusion criteria were found. Studies on improving athletic performance were the most common, with ACT also being evaluated for …

The Impact Of Absolute Education On Young Voter Turnout, Reagan Roark

All Graduate Theses and Dissertations, Fall 2023 to Present

American civic education continually proves to need attention and reform. This research evaluates whether implementing specific teaching strategies at the high school level impacts a student's future political participation; specifically, to more clearly outline whether a high school level civics curriculum directly impacts a student's likelihood to cast a voting ballot in midterm and presidential elections within six years of graduation. This paper aims to understand better if teaching and/or education reform is effective in helping future generations and the democratic fate of our country. In this study, we measure the current state civic graduation requirements compared with the state's …

Navacaprant, A Novel And Highly Selective Kappa Opioid Receptor Antagonist, In Adults With Major Depressive Disorder: A Randomized, Double-Blind Phase 2 Clinical Trial, Sanjay J Mathew, Andrew J Cutler, Nicole C Visitacion, Michael Gold, Jason Yuan, Bill Aurora

Staff and Researcher Publications

PURPOSE/BACKGROUND: This phase 2a randomized, double-blind, placebo-controlled, 8-week trial assessed the efficacy and safety of navacaprant, a highly selective kappa opioid receptor antagonist, in adults with major depressive disorder (MDD).

METHODS/PROCEDURES: Participants with 17-Item Hamilton Depression Rating Scale (HAMD-17) scores of 14 to 30 were randomized 1:1 to once-daily navacaprant 80 mg or placebo (n = 102 each). The primary endpoint was HAMD-17 change from baseline (CFB) to week 8. Secondary endpoints included CFB in Snaith-Hamilton Pleasure Scale (SHAPS). No adjustment for multiple comparisons was made.

FINDINGS/RESULTS: At week 8, HAMD-17 CFB was not statistically significantly improved with navacaprant vs …

Azetukalner, A Novel Kv7 Potassium Channel Opener, In Adults With Major Depressive Disorder: A Randomized Clinical Trial, Noam N Butterfield, Constanza Luzon Rosenblut, Maurizio Fava, Christoph U Correll, Anthony J Rothschild, James W Murrough, Sanjay J Mathew, Gregory N Beatch, Celene Grayson, Cynthia Harden, Jenny Qian, Joe Mcintosh, Rostam Namdari, Christopher Kenney

Staff and Researcher Publications

Importance: Available antidepressants provide inadequate therapeutic responses in many patients with major depressive disorder (MDD), highlighting a substantial unmet need.

Objective: To evaluate the efficacy and safety of azetukalner, a novel, potent KV7 potassium channel opener, in participants with MDD.

Design, setting, and participants: X-NOVA was a multicenter, proof-of-concept, phase 2, randomized, double-blind, parallel-group, placebo-controlled clinical trial that evaluated azetukalner in participants (adults aged ≥18 to ≤65 years) with moderate to severe MDD in a current depressive episode. Participants were enrolled between April 2022 and October 2023, and data analysis occurred from January 2023 to January 2024.

Intervention: Participants were …

Leadership, Identity, And Student Voice In Secondary Schools, Gordon S. Geddes

All Graduate Theses and Dissertations, Fall 2023 to Present

Many student leadership programs in U.S. high schools operate without clear guidance, often leaving students as passive participants in systems that may not effectively prepare them for leadership roles both in school settings and elsewhere. This study explores how listening to students’ voices can improve leadership programs by better understanding how young people see themselves as leaders. Using a case study approach at one school, I observed student leaders over one school year and analyzed their experiences through leadership development theories. The findings suggest that when schools take students' perspectives into account, they can create leadership programs that are more …

The Impact Of General And Religious/Spiritual Minority Stressors On Lgbtq Spiritual Health, Adlyn Perez-Figueroa

All Graduate Theses and Dissertations, Fall 2023 to Present

A great deal of research has focused on the impact of minority stress on the mental and physical health of lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals, but little is known about how minority stress impacts spiritual health. The purpose of this study was to develop a new theory of LGBTQ spiritual health. Another purpose was to explore how the impact of minority stress, such as discrimination, differs in everyday settings vs religious/spiritual (R/S) settings. A total of 227 LGBTQ participants were recruited online using a Prolific Survey Panel. Multiple regression analyses were used to determine: (a) if minority …

Challenging Behavior In Inclusive Postsecondary Education Programs, Samantha J. Nercesian

All Graduate Theses and Dissertations, Fall 2023 to Present

Inclusive postsecondary education programs – higher education programs that are specifically designed for individuals with intellectual disabilities – have grown exponentially in the last 10 years. With this growth has come the emergence of several barriers to inclusive postsecondary education admission and completion. Given the relatively short time inclusive postsecondary education programs have existed, only a small amount of research has looked into barriers that prevent graduation from inclusive postsecondary education programs. One barrier in particular has received little to no attention from researchers – challenging behavior. Challenging behavior is a construct that includes socially inappropriate behaviors, which may harm …