Digital Commons Network^™

Top-Down Control And Bottom-Up Salience Guide Attention During Visual Search, Christopher Ahn

Arts & Sciences Graduate Student Theses and Dissertations

We search the visual world using different strategies, some of them relying on bottom-up salience, others on top-down expectations. However, little is known about how we arbitrate between them. Here, we report a study investigating whether people are sensitive to environmental regularities that incentivize different strategies with differential effort requirements. To test this, we used a visual search task in which people need to search a target in a field of items, each of which is printed in one of two colors. This task allows us to parametrically manipulate bottom-up salience by varying the number of items with the less …

Lefitolimod In Combination With Ipilimumab In Patients With Advanced Solid Tumors: A Phase I Trial, Mirella Nardo, Mohamed A Gouda, Matthew J Reilley, Amadeo B Biter, Joann Lim, Stacie A Bean, Ly M Nguyen, Priya R Bhosale, Casey R Ager, Coline A Couillault, Sarina A Piha-Paul, Siqing Fu, Apostolia M Tsimberidou, Timothy A Yap, Aung Naing, Jordi Rodon, Vivek Subbiah, Daniel D Karp, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

Introduction: TLR9 agonists are immunomodulators that have been of interest for combined use with cancer immunotherapy. TLR9 agonists, such as lefitolimod (MGN1703), significantly increased Th1 response in preclinical models and have demonstrated efficacy in early clinical trials. This trial assessed the safety and preliminary efficacy of the combination of lefitolimod and ipilimumab in patients with advanced solid tumors.

Methods: This was a single-center, open-label, investigator-initiated phase I trial conducted at The University of Texas MD Anderson Cancer Center. Patients received leftolimod either subcutaneously (at escalating doses of 15-120 mg) or intratumorally (at the maximum feasible dose) in combination with ipilimumab …

Tumoral And Circulating Genomic Landscape Inform Survival Differences In Colorectal Carcinomatosis, Michael G White, Reed I Ayabe, Mohammad A Zeineddine, Fadl A Zeineddine, Abdelrahman M G Yousef, Mahmoud Yousef, Norman J Galbraith, J Bryan Iorgulescu, Christopher Scally, Keith Fournier, Timothy E Newhook, Nancy Y You, Jason Willis, Scott Kopetz, George J Chang, John Paul Shen, Abhineet Uppal

Faculty, Staff and Student Publications

Colorectal peritoneal metastases (CPM) are the third most common site of metastatic spread of colorectal cancer and are associated with worse survival than other sites of metastatic disease. In recent years tumoral circulating tumoral DNA (ctDNA) mutational status has been increasingly utilized in clinical decision making for metastatic colorectal cancer patients despite its utility in CPM being poorly understood. Here we describe standard of care performed mutational profiles and associated outcomes for unresectable CPM patients, with a contextual comparison to 160 unresected colorectal liver metastases (CLM) patients. Of 508 patients, 288 (57 %) had CPM alone and 220 (43 %) …

Unveiling The Intercompartmental Signaling Axis: Mitochondrial To Er Stress Response (Mersr) And Its Impact On Proteostasis, Jeson J Li, Nan Xin, Chunxia Yang, Bo G Kim, Larissa A Tavizon, Ruth Hong, Jina Park, Travis I Moore, Rebecca George Tharyan, Adam Antebi, Hyun-Eui Kim

Faculty, Staff and Student Publications

Maintaining protein homeostasis is essential for cellular health. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response, activated by the perturbation of mitochondrial proteostasis, which ultimately results in the improvement of proteostasis in the cytosol. Here, we found that this signaling axis also influences the unfolded protein response of the endoplasmic reticulum (UPRER), suggesting the presence of a Mitochondria to ER Stress Response (MERSR). During MERSR, the IRE1 branch of UPRER is inhibited, introducing a previously unknown regulatory component of MCSR. Moreover, proteostasis is enhanced through the upregulation of the PERK-eIF2α signaling pathway, increasing phosphorylation of eIF2α and …

Using A Surgical Risk Predictor To Estimate Percutaneous Cryoablation Adverse Event Risk: A Single Center Comparative Analysis, Prisha Patel, Koustav Pal, Hadi Ahmed, Bill Tang, Iwan Paolucci, Mohammad Khavandi, Peiman Habibollahi, Ketan Shah, Steven Y Huang, Bruno C Odisio, Sanjay Gupta, Kamran Ahrar, Steven Yevich, Joshua D Kuban, Alda Tam, Rahul A Sheth

Faculty, Staff and Student Publications

Objective: To evaluate the relevance of established surgical risk calculators for predicting complications in patients undergoing percutaneous lung cryoablation (PLC).

Methods: The institution's database was queried for PLC procedures from March 2015 to May 2024, excluding those patients with concomitant local therapies or five or more lesions treated in a single setting. Demographics, frailty metrics as defined by the surgical literature, and procedural variables were collected. To evaluate the suitability of surgical risk estimate calculators, the requisite demographic data were input into the American College of Surgery surgical risk calculator; estimates for length of stay (LOS), serious complications, 30-day readmission, …

Natural History Models For Lung Cancer: A Scoping Review, Renu Sara Nargund, Sayaka Ishizawa, Maryam Eghbalizarch, Paul Yeh, Seyyed Mostafa Mousavi Janbeh Saray, Sara Nofal, Yimin Geng, Pianpian Cao, Edwin J Ostrin, Rafael Meza, Martin C Tammemägi, Robert J Volk, Maria A Lopez-Olivo, Iakovos Toumazis

Faculty, Staff and Student Publications

Introduction: Natural history models (NHMs) of lung cancer (LC) simulate the disease's natural progression providing a baseline for assessing the impact of interventions. NHMs have been increasingly used to inform public health policies, highlighting their utility. The objective of this scoping review was to summarize existing LC NHMs, identify their limitations, and propose a framework for future NHM development.

Methods: We searched MEDLINE, Embase, Web of Science, and IEEE Xplore from their inception to October 5, 2023, for peer-reviewed, full-length articles with an LC NHM. Model characteristics, their applications, data sources used, and limitations were extracted and narratively synthesized.

Results: …

Dose Prediction Via Deep Learning To Enhance Treatment Planning Of Lung Radiotherapy Including Simultaneous Integrated Boost Techniques, Wenhua Cao, Mary Gronberg, Stephen Bilton, Hana Baroudi, Skylar Gay, Christopher Peeler, Zhongxing Liao, Thomas J Whitaker, Karen Hoffman, Laurence E Court

Faculty, Staff and Student Publications

Background: Recent studies have shown deep learning techniques are able to predict three-dimensional (3D) dose distributions of radiotherapy treatment plans. However, their use in dose prediction for treatments with varied prescription doses including simultaneous integrated boost (SIB), that is, using multiple prescription doses within the same plan, and benefit in improving plan quality should be validated.

Purpose: To investigate the feasibility and potential benefit of using deep learning to predict dose distribution of volumetric modulated arc therapy (VMAT) including SIB techniques and improve treatment planning for patients with lung cancer.

Methods: The dose prediction model was trained with 93 retrospective …

Post-Operative Hemodynamic Instability After Tcar (Transcarotid Artery Revascularization): A Retrospective Study, Lutfi Barghuthi, Rebekah Bjorklund, Mya Phelps, Shrina Patel, Lakecia Beasley, Bayli Zink, Alyssa Bedell, Gaurav Singh, Sarah Stokke, Rebecca Swindall, Allen Cook, Mark Robbins

School of Medicine Student Publications and Presentations

Introduction: Postoperative hemodynamic instability following carotid revascularization can lead to adverse outcomes such as Intensive Care Unit (ICU) admission and prolonged hospitalization, leading to an increase in total hospital charges. This study aimed to compare hemodynamic instability between Transcarotid Artery Revascularization (TCAR) and Carotid Endarterectomy (CEA) in a rural setting. Methods: A retrospective cohort study was conducted at a single institution on treatment for carotid artery stenosis between 2021 and 2024. Clinical outcomes following TCAR and CEA were compared. The primary outcome was hemodynamic instability; secondary outcome was ICU admission. Results: In total, 546 patients were included, 72.5% undergoing TCAR …

A Case Of Persistently Positive Mpox Pcr For 1 Year In A Patient With Advanced Hiv, Haitham Alaithan, Neha Venkatesh, Prathit A Kulkarni, Richard J Hamill, Maria C Rodriguez-Barradas

Faculty, Staff and Students Publications

Mpox (previously called monkeypox) is a self-limited vesiculopustular skin disease caused by the monkeypox virus. Symptoms and skin findings typically resolve within 4 weeks in immunocompetent patients. This report describes a case of persistent Mpox infection with polymerase chain reaction positivity lasting greater than 1 year after initial infection in a patient with advanced HIV.

Reliability Of Longitudinal Sleep Monitoring In Amyloid-Negative And Amyloid-Positive Older Adults., Taylor Pedersen

Arts & Sciences Graduate Student Theses and Dissertations

Sleep disturbances are associated with Alzheimer’s disease (AD) pathology and cognitive symptoms, but longitudinal studies exploring sleep, AD biomarkers, and cognition are limited. Understanding changes in sleep among older adults with and without AD pathology is crucial for appropriately designing longitudinal studies of aging and AD. To assess this, sleep was longitudinally assessed (over ~3.5 years) in amyloid-negative and amyloid-positive older adults using self-reported logs, questionnaires, and at-home monitoring with a single-channel electroencephalography (EEG) device. Amyloid imaging and cognitive assessments were also performed. Test-retest reliability was evaluated using intraclass correlation coefficients, and power analysis determined sample sizes for longitudinal observational …

The Farewell Tour: Extended Program Notes For The Graduate Recital Of Michalah “Micy” Troutt, Michalah M. Troutt

Research Papers

The purpose of this research paper is to provide background information about the composers and their respective pieces and shed light on the ways that these pieces stand out amongst other percussion repertoire. The diversity of the pieces chosen reflects a recital program comprised of a full percussion curriculum including works for marimba, snare drum, timpani, and even tambourine. Two of the pieces also feature electronic backing tracks. The pieces performed on this program are Triptych Boom by Chad Floyd, Starlight Meadow by Robert Clayson, Easy Money by Christopher Butler, Preludio No. 1 by Ney Rosauro, Conversation for Two Tambourines …

Supercritical Water Oxidation And A Preliminary Concept For Lunar Application, Sheldon Cameron Scott

All Theses

As the reach of space exploration extends further from Earth, the cost, time, and energy requirements necessary for life support of crewed expeditions exponentially increases. This makes the reclamation of resources paramount to the viability of such missions and will eventually become a major constraint for future destinations due to the expensive delivery of materials. Thusly, Supercritical Water Oxidation (SCWO) has been proposed to meet the requirements for the recovery of potable water needed for the drinking, hygiene, laundry, and irrigation performed by astronauts. This technique utilizes supercritical water’s properties above 374°C and 22.1 MPa alongside oxidants to convert organic …

Identification, Removal, And Characterization Of Microplastics From Pvamu Wwtp Effluent Using Ceramic Membranes, Ogboru O. Chujor

All Theses

This study evaluated a 1.4 µm ceramic membrane's effectiveness in removing microplastics from wastewater, focusing on characterization via FTIR spectroscopy. Microplastics, including fibers, fragments, and microbeads (1-2500 µm), were visually identified and counted under an electron microscope, achieving a 94% TSS reduction and a 35.4% microplastic recovery rate. FTIR analysis identified key polymers like polyethylene, polypropylene, and polystyrene, with distinctive peaks for polyester (1624 cm−1, 1737 cm−1) and cotton (1095 cm−1, 1119 cm−1, 1151 cm−1), indicating polymer degradation through spectral signs of carbonyl groups. Micro-FTIR imaging, enhanced by dyes like DANs under fluorescence and Rose Bengal, pinpointed polymer sources and …

Biochar And Manure Levels: Impact On Selected Soil Hydro-Physical Parameters And Sorghum Canopy Temperature, Catana Faison

All Theses

Climate-smart agriculture (CSA) enhances crop yields and maintains healthy soils while also contributing to strategies that mitigate climate change. One of the main aspects of CSA is its impact on soil and environmental conditions, such as structural stability, moisture retention, temperature regulation, and canopy development, which are fundamental to sustainable crop production and land management. Soil organic amendments, e.g., biochar, and chicken and dairy manure applications, substantially improve soil hydrological properties and structure. This thesis reports on the impact of three organic amendment types and rates on selected soil hydrological and physical properties, including water holding capacity, heat capacity, aggregate …

Under Siege: Marriage, Family And The Great Controversy, Jasmine Fraser

Faculty Publications

No abstract provided.

Naomi Pelayo Senior Violin Recital, Andrews University

Student Degree Recitals 2024-2025

Naomi Pelayo presents her Senior Recital Añoranza. Featuring works by Brahms, J.S. Bach, Silvestrov, Sarasate, Wieniawski, and José Sabre Marroquín.

A Remarkable Look At Sentencing For A Remarkable Set Of Drug Defendants, Douglas A. Berman, Steven L. Chanenson

Faculty Publications

A new dataset capturing sentencing outcomes for “boat defendants,” a notable group of federal drug offenders who share many characteristics, provides a fresh perspective on many different aspects of federal case-processing and drug-sentencing outcomes. This overview provides a brief look at ground- breaking research based on this dataset, which serves as an anchor article for this issue of the Federal Sentencing Reporter, followed by a history of the creation of this dataset and then commentaries highlighting insights and lessons drawn from this original research.

Antiracist Expert Evidence, Jasmine Gonzales Rose, Asees Bhasin, Spencer Piston

Faculty Scholarship

Since 2020, when mass protests against racism swept across the United States, scholars, lawyers, and the general public have become increasingly aware that racism permeates society and the criminal legal system, from overt racial animus to the nuanced effects of structural racism. Demonstrating the influence of racism is therefore vital to the practice of criminal defense, yet many attorneys do not know how to prove racism in court. We surveyed over seven hundred criminal-defense attorneys across the United States, and nearly half had never heard of expert witnesses testifying or submitting written reports on racism—what we call “antiracist expert evidence.” …

May 1, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Computation-Driven Design And Synthesis Of Molecular Sensors For Surface-Enhanced Raman Spectroscopy In Liquids, Junhu Zhou

Dartmouth College Ph.D Dissertations

The reliable detection of molecules in liquid environments is a continuing challenge in chemical sensing and biological diagnostics. While surface-enhanced Raman spectroscopy (SERS) is well-recognized for its high sensitivity and molecular specificity, conventional platforms – based on colloidal nanoparticles or patterned substrates – have shortcomings. These conventional configurations struggle with signal reproducibility, non-uniform hotspot distribution, and, critically, restricted accessibility for large targets such as proteins and exosomes.

This thesis develops a computation-guided approach to developing next-generation SERS sensors capable of overcoming these persistent obstacles. At the heart of the study is the design and fabrication of metal-insulator-metal (MIM) nanoparticles, where …

Hybrid Dc-Dc Converters For Soft Charging Capacitive Actuators: Modeling, Analysis And Design, Bahlakoana Mabetha

Dartmouth College Ph.D Dissertations

Recent trends in haptics, microrobotics and ultrasound technology have shown an increasing use of piezoelectric and other electrostatic actuators. These actuators are suited for miniaturized applications due to their high power density and favorable scalability at a small size. Their electrical impedance at lower frequency (their typical operating range) is capacitive, therefore, they can be modeled as capacitive loads.

The driving circuits for capacitive actuators need to deliver and recover (bidirectional) dominantly reactive power, unlike typical power electronics converters for resistive loads which deliver (unidirectional) real power to the load. Therefore, the circuits, operation, and optimization required to drive these …

A Synoptic Analysis Of Hurricane Andrew, Alice E. Schipper, Mark R. Sinclair

Student Works

Hurricane Andrew was a historic Category 5 storm that made landfall in southern Florida on the morning of 24 August 1992. Andrew’s landfall brought massive destruction, with entire neighborhoods in the city of Homestead, Florida destroyed. There were 250,000 people left homeless in the US over its entire track, and cost US$25 billion in damage, the costliest hurricane in United States history up to that point. A synoptic analysis was completed to study the tropical and subsequent extratropical phases of this destructive storm. During Andrew’s tropical phase it was found that strong vertical shear initially impeded development. As this dissipated, …

Final Butte Priority Soils Operable Unit (Bpsou) Unreclaimed (Ur) Sites: Ur-35 Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022 Annual Operations And Maintenance Report 2022 Bres Annual Summary Report For Work Completed In Quadrant 2, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2023 Annual Operations And Maintenance Report 2023 Bres Annual Summary Report For Work Completed In Quadrant 3, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Mixing-Controlled Compression Ignition Of Ethanol Using Exhaust Rebreathe At A Low-Load Operating Condition—Single Cylinder Experiments In A Heavy-Duty Diesel Engine, Tyler Johnston, Jared Zeman, Adam Dempsey

Mechanical Engineering Faculty Research and Publications

As pollutant emissions regulations in the heavy-duty sector become further stringent, the energy requirements in this sector continue to increase. Due to the high-power density and operating period requirements within this sector, full electrification is challenging. A viable solution to meet the stringent requirements for criteria pollutant and greenhouse gas (GHG) emissions is the use of low carbon renewable fuels. Low carbon renewable fuels are desirable due to their lower carbon content per unit energy compared to conventional fossil diesel fuel. However, implementing some low carbon renewable fuels in the heavy-duty sector poses challenges due to their low reactivity and …

Filling Your Own Cup: Self-Care Strategies For Campus Visit Professionals, Angeni Worley

Faculty and Staff Publications & Presentations

Campus Visit Coordinator Angeni Worley '25 presented an educational session. Worley used her knowledge as a Clinical Mental Health Counseling student to inspire other campus visit professionals to "fill their cup" and prioritize self-care. She led her group through a series of self-care practices and focused on the importance of mental wellness in the office and at home to sustain energy, boost enthusiasm, and build resilience.

A Comparative Analysis Of Advertising Appeals In Anti- Smoking Advertisements (Print And Online Display Ads) From 1990s To 2020s In The U.K, Ayomide Adebare Mr, Jill Nash Dr

Journal of Applied Marketing Theory

This study provides a comparative analysis of advertising appeals in static anti-smoking advertisements in the U.K. from the 1990s to the 2020s, using quantitative content analysis. The research evaluates print and online display advertisements, focusing on the prevalence of rational (gain-framed and statistical) and emotional (fear and guilt) appeals. The study investigates shifts in appeal usage over time and the broader societal and regulatory influences driving these changes. Findings indicate a strategic shift in public health messaging, moving from fear-based appeals in the 1990s to increased reliance on gain-framed appeals by the 2020s. This study enhances academic understanding of how …

Comments From The Editors, Tulay Girard, Brian Whelan

Journal of Applied Marketing Theory

Welcome to the Spring 2025 issue of the Journal of Applied Marketing Theory. The Journal of Applied Marketing Theory (JAMT) is dedicated to providing a reputable platform for the dissemination of academic research that both advances marketing knowledge and offers practical insights for marketing professionals.

In this issue, we are pleased to feature six manuscripts that explore a diverse range of topics within the field. Each article was well-received by our review team and contributes valuable perspectives to current marketing discussions. We are delighted to share these contributions with our readers and hope you find them both insightful and thought-provoking.

Sealing The Leak: Transcatheter Repair Of Anterior Mitral Leaflet Perforation With Amplatzer Vascular Plug 4., Zeryab A Khan, Cody Carter, Jordan Luli, Nathan Marzlin, Johnathan Hatanelas, Lindsay Castle, Kevin Stiver, Laura Flannery, Steven J Yakubov, Carlos Sanchez

Heart and Vascular Articles

We document the first reported use of the Amplatzer Vascular Plug 4 for anterior mitral leaflet perforation repair in a 56-year-old male who had undergone valve-in-valve transcatheter aortic valve replacement. Previously reported cases involving the use of other occluder devices for mitral leaflet perforation repair either required guide catheter or delivery sheath exchanges, arteriovenous wire loop for deployment, or use of mitral transcatheter edge-to-edge repair for leaflet stability. Our case highlights the efficacy of the bilobar-designed Amplatzer Vascular Plug 4 for precise occlusion in anterior mitral leaflet perforation through antegrade-only delivery and safety through the simplification of procedural steps.