Decision Space Decomposition For Multiobjective Programs, Emma Soriano

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Being inspired by the parametric decomposition theorem for multiobjective optimization problems (MOPs) of Cuenca and Miguel (2017), and by the block- coordinate descent for single objective optimization problems, we present a decom- position theorem for computing the set of minimal elements of a partially ordered set. This set is decomposed into subsets whose minimal elements are used to retrieve the overall minimal elements. We apply this approach to strictly convex MOPs de- composing their decision space into lines. The line decomposition benefits from the fact that a multiobjective line search problem is equivalent to solving a collection of single objective …

The Quest For Kindergarten Readiness: A Study Of One District’S Early Implementation Of The Pyramid Model For Promoting Social-Emotional Competence, Ginny L. Gast

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Participation in high-quality preschool programs can help prepare young children for Kindergarten, and children demonstrating Kindergarten readiness are more likely to achieve positive outcomes later in life. With this in mind, Oakwood School District (OSD) set a strategic goal to improve the Kindergarten readiness levels of students participating in its 4K programs from 18% in 2021 to 70% by 2025. With research suggesting that school readiness outcomes are dependent on preschool program quality variables such as student-teacher relationships and emotional competencies, the Pyramid Model for Promoting Social-Emotional Competence in Infants and Young Children was implemented in OSD’s 4K program sites …

Biophysical Studies Of Nucleic Acid - Small Molecule Recognition, Andrea Conner

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The presented work is a collection of studies performed to examine small molecule recognition of nucleic acids. Recognition of nucleic acids was examined using two types of small molecules: aminoglycosides and Hoechst dyes. Chapter One focuses on established experimental techniques (i.e. absorbance, isothermal titration calorimetry, flow cytometry, cell microscopy, etc.) in small molecule recognition of nucleic acids. The emphasis of studies in the group has been on two focus areas. (i) Thermodynamic characterization of mixed A-form and B-form DNA or RNA conformation with aminoglycosides, particularly neomycin-class. (ii) Characterization of new Hoechst-morpholine (HT-MO) derivatives’ interactions with nucleic acids.

Focus area (i) …

The Genomic Landscape And Prognostic Impact Of Kras, Stk11, And Smarca4 Mutations And Co-Mutations On Survival Outcomes In Non-Small Cell Lung Cancer, Peter Manolakos

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Non-small lung cancer (NSCLC) accounts for 85% of lung cancer cases, and Kirsten rat sarcoma viral oncogene homolog (KRAS), Serine/Threonine Kinase 11 (STK11), and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4) mutations and co-mutations have been increasingly recognized for their potential prognostic significance. However, clear knowledge gaps remain regarding which treatments should be selected for patients who present clinically with KRAS/STK11 or KRAS/SMARCA4 co-mutations, as outlined in Chapter 1. Despite significant clinical development advancements in immunotherapy and targeted therapy, a deeper understanding of the influence of these genomic …

Learning Through Online Participation: From Breakout Rooms To Discord, Makayla Moster

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For software development teams, teamwork is an essential part of their day-to-day lives. However, due to the aftermath of the COVID-19 pandemic, more companies have allowed employees to have more hybrid and remote work options than before. As more companies are adopting hybrid and remote workstyles, we need to ensure that we are preparing the next batch of young software developers to conduct teamwork in remote and hybrid settings. In this dissertation, I address the tools students use for teamwork and how to improve their teamwork inside and outside of the classroom. I present my research on improving student experiences …

Countering Deficit Narratives Through A Blackcrit Lens By Examining Case Studies Of Black College Mathematics Students’ Classroom Experiences, Akhenaton Wilbourn

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This dissertation examines the lived experiences of 11 Black college mathematics students at their predominantly white institution (PWI) through the lens of Black Critical Theory (BlackCrit) to counter deficit narratives about the racial achievement gap (RAG) in mathematics education courses. Deficit narratives often attribute disparities between Black and white students’ mathematical performance to assumed deficiencies in Black students’ abilities rather than systemic inequities, historical marginalization, and ongoing anti-Blackness in educational settings (Cobb & Russell, 2015; Kress, 2021). Using multiple case studies, this study explores how anti-Blackness manifests in mathematics classrooms, how students navigate tensions between multiculturalism, neoliberal educational policies, and …

Adaptive Delay Compensation Frameworks For Distributed Real-Time Co-Simulation In Power Systems, Elutunji Buraimoh

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This dissertation presents a model-free, adaptive delay prediction and compensation framework for geographically distributed real-time power system co-simulation environments. Communication delays—both constant and real-time-varying—significantly degrade the accuracy, fidelity, and stability of co-simulated systems, particularly in dynamic and transient analyses of partitioned power systems. To address this, a predictor-based framework is developed that compensates for delays without requiring system models, computationally intensive signal transformations, or manual intervention.

The proposed solution leverages a Damping Impedance Method as the interface algorithm, combined with a sliding-mode control-inspired predictor system. Both single-parameter and multi-parameter predictor configurations are implemented, with the multi-parameter design providing an additional …

Probing The 'Mev Gap': Discovery And Characterization Of Persistent And Transient Mev-Gev Gamma-Ray Sources With The Fermi Large Area Telescoope, Scott Joffre

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The MeV Gap is a moniker for the energy regime E~0.1-100 MeV that has lacked sensitive observations for the last 20 years. This is not out of scientific disinterest, but observational challenges. The only instrument currently available to make observations in the MeV Gap is the Fermi Large Area Telescope (LAT). For the first time ever, Fermi-LAT has been leveraged to push its observational capabilities to its absolute lower energy limit to end this 20-year observational gap. Observing the MeV sky is imperative for identifying some of the most luminous galaxies in the Universe known as blazars. The brightest blazars …

Toward The Application Of Natural Language Processing In Electronic Health Record Analysis For Taxonomy Development, Latoya Mcdonald

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Electronic health records (EHRs) are pivotal resources for nurse practice because they increase the timeliness and reliability of patient information at the point of care and support access by multiple healthcare providers and the individual patients themselves. However, it is widely recognized that data extraction from EHRs is challenging due to the variability in the language used in clinical care notes and the lack of standardized terminology across healthcare systems. The broad objective of this dissertation is to develop taxonomy-based classification models for nursing care by applying feature engineering approaches to EHRs that include nursing care of ostomy patients following …

Development Of Small-Molecule Inhibitors For Bacteroides, Naegleria, And Toxoplasma Microorganisms And Synthesis Of N-Heterocycles From Thiolated Ene-Ynes And Azodicarboxylates, Samuel Kwain

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Humans and microorganisms are intricately interconnected, with microbes constituting an essential component of human biology and ecology. This interdependence necessitates a delicate balance between leveraging beneficial microbes and mitigating the impact of harmful ones. The human gut microbiome, home to trillions of microorganisms, predominantly comprises commensal species that support health. However, dysbiosis within this ecosystem has been linked to serious diseases. For instance, an overrepresentation of Bacteroides species is associated with Type I diabetes mellitus (T1D) and various chronic gut disorders, including ulcerative colitis, inflammatory bowel disease, celiac disease, and colorectal cancer. Similarly, Naegleria fowleri, a free-living amoeba, causes …

Exploring Community Change Of North American Stream Fish Communities Due To Species Introductions, William K. Annis Jr

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The introduction of nonnative species has facilitated global changes in beta diversity, and these changes have been coined biotic homogenization (loss in beta diversity) and differentiation (gain in beta diversity). Homogenization represents a key conservation threat. Therefore it is imperative to understand the processes that allow nonnative species to establish and how these species contribute to beta diversity change. In this dissertation, I assess three key challenges exist in our ability to address these goals. One challenge is that we have inconsistent support among hypotheses of invasion drivers due to context dependency. Context dependency can arise due to differences in …

Mapping Teacher And Librarian Perspectives Through A Qualitative Descriptive Study Of Book Bans In South Carolina, Jennifer Gallman

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This study analyzed findings from four data collection pieces with Critical Discourse Analysis, in which participants met in focus groups to discuss their experiences with book bans and curriculum censorship. The five focus groups included Upstate middle school English teachers, Upstate high school English teachers, Upstate middle school librarians, Upstate high school librarians, and participants from the Midlands and Lowcountry of South Carolina. There were two primary research questions and two sub-questions: (1) What do educators and librarians in grades 6-12 say about how power functions in engaging or challenging current curricula and book censorship trends?; (1a) How do middle …

The New Road Chosen: An Examination Of Why Black Educators Are Choosing Alternative Certification Pathways, Devin Aucoin

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This narrative study explores the experiences of eight Black educators who entered the teaching profession through alternative certification programs. Alternative certification programs were originally designed to address teacher shortages by providing individuals with a college degree a fast-track route to teacher licensure; however, research reveals an extreme shortage of Black educators and a growing number of Black educators completing alternative certification pathways. Grounded in Black Critical Theory (BlackCrit) and Social Cognitive Career Theory (SCCT), this study examines how anti-Blackness impacts the Black educator pipeline and how self-efficacy beliefs, perceived outcomes, personal goals, and contextual variables influence career decisions. Findings reveal …

Real-Time Active Thermal Management And Degradation Forecasting Of Power Electronics Building Blocks In All-Electric Ships, Ali Moghassemi

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With advancements in semiconductor technology, power electronic devices play a critical role in modern power systems, enabling efficient energy conversion in applications such as renewable energy integration, electric vehicle drives, industrial automation, and Navy ship power systems. However, the increasing use of power converters presents challenges such as harmonic reduction, cost optimization, reliability improvement, and thermal management, especially in weight- and space-constrained environments like wind turbines and shipboard systems. High-frequency switching, while reducing passive filter size, increases thermal stress on semiconductor devices, impacting efficiency and longevity. Active thermal control, which regulates junction temperature through power loss management, and degradation forecasting, …

Upstate South Carolina Mental Health And Sport Initiative: Contributing Solutions To The Mental Health Crisis Via Improvement Of Mental Health Literacy Among Adults In Youth Sport Communities, Margaret Domka

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This study contributed solutions to the youth mental health crisis by providing effective options for mental health awareness training (MHAT) that can be utilized in youth sport for increasing mental health literacy (MHL) among adults. Widely implementing MHAT has the potential to improve youth mental health status through increased help-seeking behaviors by adults. This study first evaluated whether mental health status and MHL are correlated in a youth sport setting with significant results indicating that investing time and resources into MHAT is worthwhile. Next, two MHAT modules were evaluated to determine their effectiveness for increasing MHL among this audience, i.e., …

The Spectral Asymptotics Of Toeplitz Operators On Hilbert Spaces Of Analytic Functions, Trevor Camper

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Many physical systems, whether they are ocean waves or particles moving through space, can be described using the mathematical language of “partial differ- ential equations.” In many circumstances, it is useful to study how these equations amplify an input to the equation, in which case the amplification factor is called an “eigenvalue.” The usefulness of these amplification factors is that they can be used to describe properties of the physical system. In this dissertation, I have studied this amplification factor for a related set of equations called “Toeplitz operators.” In par- ticular, I have studied eigenvalues using statistical techniques. The …

Preparing Preservice Teachers To Support Culturally And Linguistically Diverse Students Through The Implementation Of A High Leverage Practice, Mya Kelley

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The student population of United States (U.S.) schools is becoming more culturally and linguistically diverse. Similarly, students identifying as culturally and linguistically diverse students represent approximately 54% of students served under the Individuals with Disabilities Act (U.S. Department of Education, 2023). Despite increased ethnic diversity among students, the teacher workforce remains relatively homogenous, with most teachers identifying as White. Consequently, many new teachers feel ill-equipped to implement effective, evidence-based instructional practices to support culturally and linguistically diverse students. To prepare preservice teachers to meet culturally and linguistically diverse students' unique needs, teacher preparation programs must embed culturally relevant pedagogy and …

Ex Vivo Multiplex Knockdown Of Angptl3 And Cypor In Hepatocytes As A Novel Cell Therapy For Familial Hypercholesterolemia, Callie D. Clark

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Inherited metabolic diseases (IMDs) affect approximately 1 in 800 individuals. The only curative treatment for IMDs is liver transplantation. However, transplantation carries significant risks, including organ rejection and a lifelong need for immunosuppression. Therefore, gene editing has emerged as a promising alternative to liver transplantation for treating IMDs.

Familial hypercholesterolemia (FH) is and IMD characterized by elevated LDL-C levels resulting in premature cardiovascular disease. CRISPR-Cas9-mediated gene editing to disrupt the gene encoding angiopoietin-like 3 (ANGPTL3) in the liver represents a novel therapeutic approach for FH. Nonviral delivery performed ex vivo is safer than systemic delivery because gene editing is in …

Live-Streaming E-Commerce: The Role Of Firms And Influencers In Driving Sales, Jingyun Hu

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Livestreaming is a transformative technology that removes the limitations of time and lo- cation, enabling real-time interaction between hosts and audiences. When combined with online shopping, it creates livestreaming e-commerce, a fast-growing marketing channel where influencers promote products live and engage directly with consumers.

My doctoral dissertation explores how firms and influencers collaborate effectively in this emerging retail space. Livestreaming e-commerce offers new opportunities for reaching consumers, but also raises questions about how to manage partnerships and present products in a dynamic, real-time setting. Specifically, I investigate how firms should choose and switch influencers over time, and how influencers can …

The Math Doesn't Add Up: Gender Inequity In Service Responsibilities In Research-Intensive Mathematics Departments, Sarah Otterbeck

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Academic service responsibilities (e.g., committee work, mentoring), in the most informal definition, are those tasks faculty perform that are neither research nor teaching. However, the simplicity of this definition undercuts not only the tremendous impact service can have on faculty efforts but also the well-documented, disproportionately high service burden carried by faculty with marginalized identities. This study, grounded in the existence of gender inequities in service responsibilities, comprises three interconnected papers that collectively address the overarching research question: How do math faculty at research-intensive institutions perceive, describe, and navigate gender inequities in service responsibilities? Utilizing the framing of Intersectional Feminism …

Defining, Defending, & Delusion: White Social Studies Teachers Grappling With Whiteness, Meghan E. Moore-Hubbard

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This study explores rural white social studies teachers’ understandings of their whiteness and racial identity. In this multiple-case study, four participants engaged with a reader designed to elicit discussion and reflection on whiteness. Over the course of one week, teachers read works by George Lipsitz, Reverend Thandeka, Charles W. Mills, and James Baldwin. Grounded in the work of these scholars and the theory of Critical Whiteness Studies, this study asked participants to reflect on, discuss, and design lesson plans to be implemented in their classrooms based on their understanding of whiteness. Data was gathered in the form of interviews, reader …

Serious Leisure, Passion, And Burnout, Carson Matsick

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This study examined the relationships between aspects of serious leisure, dualistic passion, and burnout in the MBI-GS and BM. Serious leisure has been shown to improve leisure and general life outcomes, but little research considers how harmonious or obsessive leisure engagement affects these outcomes or has extended serious leisure benefits to the workplace. Overall, the study hypothesized that leisure seriousness, harmonious passion, and satisfaction with time spent in serious leisure will negatively correlate with burnout, and obsessive passion will degrade the benefits derived from serious leisure. 240 participants completed Gould's Serious Leisure Inventory, the Passion Scale, the Maslach Burnout Inventory …

Am I Woke Enough To Serve In Healthcare: A Secondary Analysis Of Pre-Health Students’ Personal And Professional Growth By Engaging In Cultural Competency Assessments, Harolynn Williams

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Healthcare providers must be equipped to serve an increasingly diverse population, yet cultural competence remains underemphasized in undergraduate pre-health education. This study explored how embedded cultural competency training influences undergraduate pre-health students’ perceptions of personal and professional growth. Using a qualitative descriptive design, the research incorporated intercultural assessments, the Intercultural Development Inventory (IDI), and the Global Competence Certificate (GCC), along with qualitative reflections from students enrolled in three versions of a cultural competence course: a year-long course, a semester-long course, and a short-term study abroad immersion six-week course. Findings revealed that students demonstrated measurable growth in cultural awareness, knowledge, communication, …

An Analysis Of Principal Influence On Teacher Retention In A Rural School District: An Exploratory Qualitative Study, Stephanie Davis

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Research shows that nearly one-third of novice teachers leave the profession before their third year, and almost half leave by their fifth year, with turnover rates remaining steady. Teacher job satisfaction and dissatisfaction are influenced by various factors, with administrative support playing a key role. This exploratory qualitative study examined how principals' leadership behaviors affect teacher retention. Through surveys and interviews with principals and teacher representatives from nine schools, the study found that positive principal leadership significantly influences teachers' decisions to stay in their schools. Principals actively engage in behaviors, both direct and indirect, that help retain teachers. The study …

Ceramic Membrane Evaluation Via Automated Filtration Systems For Water Treatment And Resource Recovery, Weiming Qi

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Membranes are an advanced and mature water and wastewater treatment technology. Membrane fouling is a key difficulty for all membrane filtration processes, leading to significant attention in the literature over the years. A common problem in laboratory-scale membrane research is that the testing methods in the laboratory are often quite different than industrial applications due to the limitations of manual experimental setups. An automated membrane filtration apparatus was built in the lab to solve this problem by allowing long-term filtration, frequent backwash and CIP, and high-accuracy operation. The filtration system achieves different cleaning strategies for both theoretical research and practical …

The Effect Of Nuclear Isomers On S-Process Nucleosynthesis, Jaad Tannous

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s-Process nucleosynthesis is a process in which stars produce elements of mass range A = 57 to 210. Since the days of B2FH, immense work has gone into quantifying and computing s-process yields and pathways. We expand upon said work along two fronts. The first front sets up the framework for proper treatment of nuclear isomers in network calculations. We apply the framework to study 85Kr, which is a pivotal isotope in the s-process chain that affects the abundance yields of Strontium and Rubidium isotopes. In particular, we are interested in the ratio of 88Sr/86Sr and 87Rb which are important …

The Effect Of Mobile Augmented Reality On The Self-Efficacy Of Adults Learning English In The U.S., Cinamon S. Bailey

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For foreign-born adults living in the U.S., learning, speaking, and understanding English is essential to be able to work, access needed resources, facilitate healthcare, communicate with teachers at a child’s school, and build relationships and communicate with others within their communities. Yet, many of these individuals have limited English proficiency and are unable to speak and understand the language well. There are some opportunities to learn English in the U.S. as a foreign-born adult, but these avenues of learning are limited in the type of personalized, contextualized, and real-world language learning opportunities that are provided. There is a need to …

Perspectives On Clinical Oncogenomics: Secondary Germline Variants Associated With Tumor Genomic Profiling In Community Cancer Care And Advanced Practitioner Oncogenomic Proficiency, Sarah Moncado

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Precision medicine in oncology is defined by the sequencing of tumor genomic variants that can be used to identify targeted treatment for patients. Secondary pathogenic and likely pathogenic germline variants (P/LPGVs) can incidentally be detected on tumor genomic profiling (TGP). With the rise in precision medicine over the past 15 years, secondary P/LPGVs on TGP have been an increasingly important clinical issue. However, there are factors that can lead to misidentification and underreporting of P/LPGVs. Germane to this clinical practice issue is healthcare provider oncogenomic literacy and proficiency.

A scoping review was conducted to evaluate the variability of the prevalence …

Essays On Credit Default Swaps, Zhao Liu

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This dissertation focuses on the investigation of the credit derivative market. It consists of an analysis of credit default swaps (CDS) based on corporate bonds and a study of the indexed CDS—the ABX.HE index, which references subprime residential mortgage-backed securities as the underlying reference entities.

The first chapter examines the CDS pricing model and explores the key determinants of the price error measured by the absolute value of the CDS-bond basis. Specifically, I assess the efficiency of different risk-free rate proxies--Treasury Yields, EFFR/OIS rates and SOFR/OIS rates--in the CDS pricing model. The result indicates that Treasury yields overperform the other …

A System And Method For Measuring Spatially Varying Surface Appearances With A Study Of Feathers, Jessica Baron-Lis

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Real-world materials, particularly biological structures such as feathers exhibit complex appearances that vary spatially across their surfaces. The field of computer graphics provides a means of understanding such surfaces through material modeling which uses both analytical models and data acquired from light-surface interactions. There are many efforts within the past decade in measuring materials for graphics, but common limitations in these works include not accounting for spatially varying properties and reliance on neural networks and synthetic datasets.

Feathers from modern birds present diverse appearances due to how light interacts with their unique hierarchical microstructures. Variations in those structures lead to …