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The Effect Of Cardiac Rehabilitation On Diastolic Heart Failure, Lucas Clouse May 2025

The Effect Of Cardiac Rehabilitation On Diastolic Heart Failure, Lucas Clouse

Doctoral Dissertations and Projects

The newest diagnosis approved for cardiac rehabilitation (CR) by the Centers for Medicare and Medicaid Services (CMS) was systolic heart failure with ejection fractions less than or equal to 35% in 2013. CMS did not approve diastolic heart failure as a diagnosis for CR as there has not been ample research done linking a possible benefit between the two. To date, limited research has been done regarding a CR’s resources (health education, exercise training, risk factor modification, meeting with dietitian) and its effects on diastolic heart failure. The purpose of this study is to evaluate if CR can improve quality …


Gen Mz Discipleship: Training A Generation To Live In The Postmodern Age, Christian E. Kolthoff May 2025

Gen Mz Discipleship: Training A Generation To Live In The Postmodern Age, Christian E. Kolthoff

Doctoral Dissertations and Projects

The church exodus of Gen MZ is one of the most significant issues affecting the health of churches in the West. Recent research has indicated that many in Gen MZ have left the church not for lack of knowledge but because of a lack of understanding of the why. It has also indicated that Gen MZ has not been trained to respond to why they are holding on to the hope of the Gospel. So, when presented with opposing views, they struggle to maintain their faith in today’s postmodern society. It is an age in which a war on ideas …


Moral Injury And Spiritual Struggles Among Christian Adults With A History Of Substance Use And Perceived Problematic Behaviors: A Phenomenological Study, Diera Shaw-Mendez May 2025

Moral Injury And Spiritual Struggles Among Christian Adults With A History Of Substance Use And Perceived Problematic Behaviors: A Phenomenological Study, Diera Shaw-Mendez

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to describe the experiences of moral injury and spiritual struggles among Christian adults from the Philadelphia tri-state area with a history of substance use or perceived problematic behaviors. Moral injury (MI) is newly studied in civilian populations. In a review of 253 studies on moral injury and substance use, only two qualitative studies explored exposure to morally injurious events amid substance use rather than as a pathway to substance use. Due to the religious characteristics of the target sample, the grounding theory for this study is Fowler’s Stages of Faith Development, which …


The Lived Self-Care Experiences Of Parents Of Children With Severe Intellectual Disabilities: A Phenomenological Study, Karen Nadine May May 2025

The Lived Self-Care Experiences Of Parents Of Children With Severe Intellectual Disabilities: A Phenomenological Study, Karen Nadine May

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to understand the lived self-care experiences of parents of children with severe intellectual disabilities (CWSID) who attend a special needs school accommodating children with various learning disabilities. Self-care is defined as a deliberate action to control problems that lead to an improved quality of life and good health. The theory guiding this study was the transactional model of stress and coping theory. The study's central research question was, “What are the lived self-care experiences of parents of children with severe intellectual disabilities (SID)?” The qualitative phenomenological design allowed the data to be …


Virtual Reality In Trauma Therapy: Clinicians Treating Posttraumatic Stress Disorder (Ptsd) With Technological Resources In Minneapolis, Minnesota, Thomas E. Covington May 2025

Virtual Reality In Trauma Therapy: Clinicians Treating Posttraumatic Stress Disorder (Ptsd) With Technological Resources In Minneapolis, Minnesota, Thomas E. Covington

Doctoral Dissertations and Projects

This dissertation aims to establish how virtual reality (VR) integrated with other technological devices in the management of posttraumatic stress disorder (PTSD). The technology will lay the foundation for how it can establish controlled and safe VR contexts that can help patients address traumatizing occurrences. I will also stress the use of virtual therapists through online tools and applications, giving access to those who cannot attend meetings in person. Also, I will examine the individualization of the treatment process through the application of digital technologies and their potential effects on the outcomes of the therapeutic process. The research also examines …


Understanding The Lived Experiences Of Post-Graduates Of A Spiritual Direction Training Program Rooted In Ignatian Spirituality: A Phenomenological Study, Traci Arends May 2025

Understanding The Lived Experiences Of Post-Graduates Of A Spiritual Direction Training Program Rooted In Ignatian Spirituality: A Phenomenological Study, Traci Arends

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to understand and explain the lived experiences of the graduates of the Spiritual Direction Training Program at the Ignatian Ways Center for Spirituality (IWCS). The theory guiding this study was Mezirow’s theory on transformative learning as it informs the transformative journey for the graduates. With this in mind, the central research question was, “What are the transformative learning experiences of graduates of the Spiritual Direction Training Program at the IWCS?” This qualitative design was appropriate because it considered the nature of the problem. The study utilized purposeful sampling of the lived experience …


Impact Of Education For Bedside Nurses In A Community Hospital To Increase Intent Or Utilization Of A Career Ladder Advancement Tool, Carrie E. White May 2025

Impact Of Education For Bedside Nurses In A Community Hospital To Increase Intent Or Utilization Of A Career Ladder Advancement Tool, Carrie E. White

Doctoral Dissertations and Projects

This scholarly project is centered on lack of engagement in a new career ladder program. This project includes the creation of career ladder education with an intent to help with understanding, support, and engagement of the nursing caregivers. Education was created to propel the work of the career ladder within a small rural hospital. The program is 12 weeks long and covers eligibility criteria, activity details, technology education, and one-on-one support for understanding of the career ladder program. The hopes for the educational program were to increase nursing satisfaction, with the intent to stay with the organization, and foster participation …


The Rise Of The Soviet Economy: How American Capitalist Corporations Helped Build The Soviet Communist Economic System, Craig A. Helf May 2025

The Rise Of The Soviet Economy: How American Capitalist Corporations Helped Build The Soviet Communist Economic System, Craig A. Helf

Doctoral Dissertations and Projects

The aim of this dissertation is to examine the depth and scope of the relationship between American capitalism and Soviet socialism during the period of Soviet industrialization in the timeframe around the First Five-Year Plan. The research focuses on the significance of American involvement and how American corporations, personnel, and methods of innovation provided the Soviet Union a comprehensive and robust foundation to build a competitive economy not only to Europe, but to the U.S. as well. An important question of the research examines how two diametrically opposed economic concepts embodied by these respective nations partnered to achieve the goals …


Technological Attitudes, Social Media Usage, And Work Ethics Among Educators, Roshani Kundaria May 2025

Technological Attitudes, Social Media Usage, And Work Ethics Among Educators, Roshani Kundaria

Doctoral Dissertations and Projects

This study examines the relationship between social media use, technological attitudes, and work ethics among K-12 educators in the United States. With the COVID-19 pandemic forcing many educators to transition to remote work and online teaching, individuals have more online presence and social interactions. Understanding how these interactions influence the values associated with work is essential. The decision to utilize a particular social media platform for personal use depends on educators’ individual needs, preferences, and circumstances. Positive and negative attitudes toward technology usage and dependence on technology were examined. The researcher found a negative correlation between technological attitudes and social …


A Novel Macroscale Model For Deformation Twinning In Magnesium Alloys, Daniel S. Kenney May 2025

A Novel Macroscale Model For Deformation Twinning In Magnesium Alloys, Daniel S. Kenney

Doctoral Dissertations and Projects

The characterization of deformation twinning in magnesium alloys is evaluated with macroscale modeling to predict material behavior and microstructure evolution with Internal State Variables (ISVs). Twinning in magnesium presents key challenges with constitutive modeling at the macroscale where the large number of grains with individual slip/twin must be generalized. This research proposes the Kearns factor (Kearns, 1965) as a method for quantifying the crystallographic texture associated with twinning and shows how the change in Kearns factors is associated with tension-compression asymmetry, anisotropic yielding and hardening, and anisotropic lateral strains. The material model developed in this work proposes a second rank …


Exploring Educator Perceptions Regarding Parental Involvement In Inner-City Alternative Schools And Programs For Students With Behavior Challenges: A Qualitative Case Study, Marcia Nicole Waller May 2025

Exploring Educator Perceptions Regarding Parental Involvement In Inner-City Alternative Schools And Programs For Students With Behavior Challenges: A Qualitative Case Study, Marcia Nicole Waller

Doctoral Dissertations and Projects

This qualitative case study explored educators' perceptions of parental involvement in an alternative school and state-run Georgia Network for Educational and Therapeutic Support (GNETS) behavior program for students with behavioral challenges in Central Georgia. The problem identified in this qualitative case study was that alternative school students have unique learning and behavioral needs that differ significantly from typically developing peers who attend regular schools requiring a more focused level of communication between parents, teachers, and administrators. The central research question was: What are the perceptions of alternative school or behavior program educators regarding parental involvement in their school setting alternative …


The Relationship Between Education And Entrepreneurship Within African American Women’S History As Evidenced By Eight Exemplary Success Stories, Louise C. Mckinney May 2025

The Relationship Between Education And Entrepreneurship Within African American Women’S History As Evidenced By Eight Exemplary Success Stories, Louise C. Mckinney

Doctoral Dissertations and Projects

The educational and economic achievements of Historically Black Colleges and Universities (HBCUs) and other institutions of learning parallel the rise of black entrepreneurial history in the 1900s. They contributed to the historical context of the African American narrative through individual development, political and social changes, educational advancement, and national and regional changes in the concept of black wealth. These institutions provided a new platform for African Americans to rebuild their lives and futures in the post-Reconstruction era. This study analyzes the connection between African American educational leadership and entrepreneurship by assessing the impact of black female educators and leaders who …


A Qualitative Descriptive Study Of Course Developer/Instructor: Incorporating Systems-Based Knowledge And A Systemic Approach To Performance-Based Instructional Design In Law Enforcement Training, Dalisay A. B. Rosado May 2025

A Qualitative Descriptive Study Of Course Developer/Instructor: Incorporating Systems-Based Knowledge And A Systemic Approach To Performance-Based Instructional Design In Law Enforcement Training, Dalisay A. B. Rosado

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive study was to explore and understand the incorporation of systems-based knowledge and a systemic approach into performance-based instructional design (PBID) in law enforcement training at a regional police academy located in the Eastern time zone of the United States. The theoretical framework for this study was based on Bronfenbrenner's ecological systems theory (EST), which underscores the notion that the practical value of knowledge is measured by its effectiveness in a real-world application, aligning with the principles of performance-based learning. The central question asked was: How do CDIs' ascribed experiences with incorporating or lacking multiple …


The ‘Monuments Men’ And Art In World War Ii, Sylvester M. Felder May 2025

The ‘Monuments Men’ And Art In World War Ii, Sylvester M. Felder

Doctoral Dissertations and Projects

This research focuses on the 'Monuments Men,’ a group of civilian and military personnel from amongst the Allied Nations in World War II who dedicated themselves to protecting, preserving, and reclaiming Europe's artistic and architectural marvels. The thesis statement is art was highly valued by both sides during the war and fell into their operational and tactical planning and that the 'Monuments Men' were crucial to rescuing looted art and helping to establish some of the finest art institutions of the Western world, aiding in art provenance research and restitution. The dominant research question is why was art sought after …


Jet: The Engine That Changed Everything What, When, How, And Why, Richard Kazares May 2025

Jet: The Engine That Changed Everything What, When, How, And Why, Richard Kazares

Doctoral Dissertations and Projects

This dissertation poses the question of just how important the introduction of jet engine technology was and is to the aviation industry and its place within the military and civilian segments of society. A corollary to that question is the premise that jet engine technology was virtually as crucial to the growth and impact of aviation as the introduction of the airplane itself. That is not to denigrate the importance of any means of flight and propulsion but to emphasize that aviation would not be anywhere close to where it is today without the jet and the level of its …


Women Leaders In Healthcare: Emotional Intelligence, Job Satisfaction, And Organizational Citizenship Behavior, Kuan-Yin T. Timothee May 2025

Women Leaders In Healthcare: Emotional Intelligence, Job Satisfaction, And Organizational Citizenship Behavior, Kuan-Yin T. Timothee

Doctoral Dissertations and Projects

The purpose of this nonexperimental quantitative correlational study was to explore the relationship between emotional intelligence (EI), organizational citizenship behavior (OCB), and job satisfaction among women in nonclinical leadership roles within the U.S. healthcare sector. As healthcare organizations adapt to technological, social, and economic transformations, they must increase their focus on cultivating EI and promoting OCB, especially in leadership roles (Bowling & Sessa, 2021; Herr et al., 2022; Marstand et al., 2021). Additionally, research has shown that EI facilitates business development and diminishes obstacles to organizational sustenance. Although prior research has established a link between EI and OCB, there is …


Climate Change And Social Vulnerability: A Case Study Of The Mexico Lerma-Cutzamala Region, Monica Munoz Miranda, Milagros Becerra May 2025

Climate Change And Social Vulnerability: A Case Study Of The Mexico Lerma-Cutzamala Region, Monica Munoz Miranda, Milagros Becerra

Sustainability and Social Justice

Climate change is reshaping precipitation patterns in Mexico, with significant regional and seasonal variations, leading to notable impacts on different components of the hydrological cycle for the whole country. The project focuses on assessing climate change and social vulnerability in the Mexico-Lerma Cutzamala hydrological region, an area that plays a critical role in the water supply to the Mexico City Metropolitan Area and has faced water scarcity issues for years. The analysis was conducted at a municipal level through a study area of 210 municipalities, extended on approximately 31,305 sq.km, with a population of over 23 million people. Using geospatial …


The Impact Of Waste Management On Green Spaces And Community Well-Being: A Case Study Of Wa Municipality, Upper West, Ghana, Al-Rauf Mahama May 2025

The Impact Of Waste Management On Green Spaces And Community Well-Being: A Case Study Of Wa Municipality, Upper West, Ghana, Al-Rauf Mahama

Sustainability and Social Justice

Urbanization in Low- and Middle-Income Countries such as Ghana has placed immense pressure on infrastructure, waste management systems, and urban green spaces. This study examines the impact of waste management practices on green spaces and community well-being in Wa Municipal, focusing on four communities: Dondoli, Mangu, Dokpong, and Bamahu. Using a participatory research approach, data collected from waste management authorities, sanitation agencies, and residents were used to examine waste composition, health impacts, and community engagement in environmental sustainability. The findings reveal that organic waste and plastics dominate waste composition, with inadequate disposal practices contributing to pollution and health issues, including …


Effects Of Environmentally Relevant Concentrations Of Roundup On Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin And Cyp1a Expressions In Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure, Md Imran Noor, Md Saydur Rahman May 2025

Effects Of Environmentally Relevant Concentrations Of Roundup On Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin And Cyp1a Expressions In Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure, Md Imran Noor, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Roundup is one of the most widely used glyphosate-based harmful herbicides in the United States as well as globally, which poses a severe risk for terrestrial and aquatic organisms. In order to identify the detrimental effects of Roundup exposure in aquatic organisms, we investigated the environmentally relevant concentrations of Roundup exposure (low dose: 0.5 μg/L and high dose: 5.0 μg/L for 2 weeks) on renin expression, oxidative-nitrative stress biomarkers (e.g., 2,4-dinitrophenol, DNP; and 3-nitrotyrosine protein, NTP), prooxidant-antioxidant enzymes expressions (e.g., superoxide dismutase, SOD; and catalase, CAT), cellular apoptosis, and cytochrome P450 1A (CYP1A) mRNA levels in the kidneys of goldfish …


Microplastics In Coastal And Marine Environments: A Critical Issue Of Plastic Pollution On Marine Organisms, Seafood Contaminations, And Human Health Implications, Rebecca Muñiz, Md. Saydur Rahman May 2025

Microplastics In Coastal And Marine Environments: A Critical Issue Of Plastic Pollution On Marine Organisms, Seafood Contaminations, And Human Health Implications, Rebecca Muñiz, Md. Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Plastic has quickly become one of the world's most prevalent environmental pollutants. Population growth has only amplified the demand, resulting in 430 million tons of plastic produced annually, with 11 million tons ending up in our oceans. Without intentional intervention, plastic waste in the oceans is expected to triple, posing severe risks for the aquatic ecosystems, animals, and humans dependent on these waters. As plastic accumulates in oceans and other water environments, the non-biodegradable particles break down into micro- and nano-plastics, invading coastal and marine organisms and causing considerable physiological and morphological damage. This is especially concerning for the millions …


Automated Identification Of Clinically Meaningful Biomechanical Phenotypes In Cerebral Palsy Through Multicenter Gait Data, Adam Graf, Joseph Krzak, Karen M. Kruger, Jon Davids, Ryan Smith, Brandon Steinlein, Anita Bagley May 2025

Automated Identification Of Clinically Meaningful Biomechanical Phenotypes In Cerebral Palsy Through Multicenter Gait Data, Adam Graf, Joseph Krzak, Karen M. Kruger, Jon Davids, Ryan Smith, Brandon Steinlein, Anita Bagley

Biomedical Engineering Faculty Research and Publications

Background

Cerebral palsy is the most prevalent motor disability in childhood, encompassing various movement disorders that affect walking. Researchers have described gait patterns in cerebral palsy, but these are often subjective and based on clinician experience. This study introduces an automated approach to objectively identify clinically meaningful biomechanical phenotypes in cerebral palsy and test it on multicenter gait data. Utilizing instrumented gait analysis, this research aims to improve treatment strategies for gait dysfunction. This study addresses whether classification algorithms can objectively identify clinically meaningful gait patterns and if severe gait deviations are more frequent in advanced forms of cerebral palsy. …


Recent And Future Trends In Osteopathic Orthopedic Surgery Residency Match Rates Following The Transition To A Single Accreditation System., Morgan Turnow, Minali Nemani, Nithin Gupta, Hayden Hartman, Taylor Manes, Tyler Williamson, Arianna Gianakos May 2025

Recent And Future Trends In Osteopathic Orthopedic Surgery Residency Match Rates Following The Transition To A Single Accreditation System., Morgan Turnow, Minali Nemani, Nithin Gupta, Hayden Hartman, Taylor Manes, Tyler Williamson, Arianna Gianakos

Medical Education Articles

CONTEXT: Medical education in the United States has undergone significant changes, specifically within the osteopathic community. In 2020, a merger occurred between the American Osteopathic Association (AOA) and the Accreditation Council for Graduate Medical Education (ACGME), forming a single accreditation system (SAS) for graduate medical education and residency placement, with the purpose to create consistency within graduate medical education and to provide equal opportunities for applicants pursuing all specialties in medicine. However, osteopathic medical students, especially students applying to competitive residencies including orthopedic surgery, have faced challenges, raising concerns about future implications within this field.

OBJECTIVES: The main objective of …


Assessing The Effectiveness And Value Of Information On Southern Illinois University Carbondale's Center For Education's (Cie) Website, Herty Tinadu May 2025

Assessing The Effectiveness And Value Of Information On Southern Illinois University Carbondale's Center For Education's (Cie) Website, Herty Tinadu

Research Papers

Abstract

The internationalization of higher education has grown significantly over the past three decades, with international students playing a crucial role in fostering academic, cultural, and economic development in host countries. University websites are pivotal in supporting international student mobility, serving as primary sources of information during the decision-making process. This study aims to evaluate the effectiveness of the Center for International Education (CIE) website at Southern Illinois University Carbondale (SIUC) in disseminating information and providing a positive user experience for international students.

The study examines factors influencing website usability, such as content clarity, website architecture, user interface design, and …


Romanticism In The Viola Repertoire From The Last 150 Years, Noah Brown May 2025

Romanticism In The Viola Repertoire From The Last 150 Years, Noah Brown

Research Papers

No abstract provided.


Preclinical Development Of Genome Editing To Treat Duchenne Muscular Dystrophy By Exon Skipping, Made Harumi Padmaswari, Shilpi Agrawal, Christopher E. Nelson May 2025

Preclinical Development Of Genome Editing To Treat Duchenne Muscular Dystrophy By Exon Skipping, Made Harumi Padmaswari, Shilpi Agrawal, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

Duchenne muscular dystrophy (DMD) is caused by loss-of-function mutations to the gene encoding dystrophin. Restoring the reading frame of dystrophin by removing internal out-of-frame exons may address symptoms of DMD. Therefore, the principle of exon skipping has been at the center stage in drug development for Duchenne muscular dystrophy (DMD) over the past two decades. Antisense oligonucleotides (AONs) have proven effective in modulating splicing sites for exon skipping, resulting in the FDA approval of several drugs using this technique in recent years. However, due to the temporary nature of AON, researchers are actively exploring genome editing as a potential long-term, …


A Qualitative Case Study On Administrators’ Leadership Practices To Improve Academic Achievement For African Americans In An Urban Elementary School In The Southeastern United States, Maria Wright May 2025

A Qualitative Case Study On Administrators’ Leadership Practices To Improve Academic Achievement For African Americans In An Urban Elementary School In The Southeastern United States, Maria Wright

Doctoral Dissertations and Projects

This qualitative intrinsic study aimed to understand what leadership practices administrators used to improve African American academic achievement in an urban school in the Southeastern United States. Bandura's theory of self-efficacy offered a structure to address the central research question: What key elements of leadership practices will best improve the academic achievement of African American children in an urban elementary school? The sample included teachers, parents, and administrators in an urban school in the Southern United States. Data was collected through semi-structured interviews, focus groups, and questionnaires. A thematic analysis approach was used for data analysis. Data collection yielded the …


A Descriptive Study Exploring The Role Church Leaders Have In Maintaining Liberty Within A Free Republic, Rashad R. Gibson May 2025

A Descriptive Study Exploring The Role Church Leaders Have In Maintaining Liberty Within A Free Republic, Rashad R. Gibson

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive study explored the assumptions, perceptions, and understood responsibility of church leaders in New England to maintain liberty and virtue in a free republic. The theory that guided this study is transformational leadership, as it emphasizes morality in both the leader and the follower (Burns, 1978; Northouse, 2015). Within the last six decades, the United States Supreme Court has made rulings to remove from public schools, prayer, general Bible reading, and the Ten Commandments (Abington School District V. Schempp, 374 U.S. 203 (1963); Facts and Case Summary - Engel V. Vitale, 1962; Stone V. Graham, …


Pembrolizumab In Patients With Advanced Miscellaneous Rare Cancers: Results From A Phase 2 Basket Trial, Mirella Nardo, Camila Braganca Xavier, Bettzy Stephen, Jeffrey A How, Justin Moyers, Vivek Subbiah, David S Hong, Aung Naing May 2025

Pembrolizumab In Patients With Advanced Miscellaneous Rare Cancers: Results From A Phase 2 Basket Trial, Mirella Nardo, Camila Braganca Xavier, Bettzy Stephen, Jeffrey A How, Justin Moyers, Vivek Subbiah, David S Hong, Aung Naing

Faculty, Staff and Student Publications

Introduction: Rare solid tumors account for one-quarter of cancers among adults in the United States, but few resources have been devoted to their treatment. We evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with rare solid tumors.

Methods: We conducted a phase 2 basket trial that included patients with rare, advanced tumors. Patients were enrolled in the study in nine tumor-specific and a 10th cohort of miscellaneous rare histologies. Patients received pembrolizumab 200 mg intravenously every 21 days. The primary endpoint was the non-progression rate at 27 weeks per immune-related Response Evaluation Criteria in Solid Tumors …


Ethical Concerns And Implications Of Expanded Carrier Screening, Emily Andres May 2025

Ethical Concerns And Implications Of Expanded Carrier Screening, Emily Andres

Undergraduate Honors Capstone Projects

The rapid evolution in the field of genetics is often met with uncertainty and skepticism. With the advancements in genetic technologies, expanded carrier screening (ECS) has emerged as a powerful tool in reproductive medicine. Traditionally, carrier screening was provided less broadly, often relying on ethnic-based approaches. However, further advancements have deemed this practice no longer equitable or widely accepted. While ECS provides prospective parents with insight into their genetic risk and may prevent severe genetic conditions, it also raises serious ethical questions for many. These concerns span medical, political, and societal facets including medicalization, defining severity, abortion, legislation, insurability, the …


The Roles Of Rnt1 And Putative Endoribonucleases In Eukaryotic Mrna Degradation, Lee-Ann Notice-Sarpaning May 2025

The Roles Of Rnt1 And Putative Endoribonucleases In Eukaryotic Mrna Degradation, Lee-Ann Notice-Sarpaning

Dissertations and Theses (Open Access)

Endoribonucleases initiate degradation by cleaving RNAs internally. Mutations in these enzymes have been shown to cause diseases such as cancer, developmental disorders, and neurodegenerative diseases. Yet, eukaryotic endoribonucleases have not been well studied, especially with regard to their role in nuclear mRNA degradation. Rnt1 is a Saccharomyces cerevisiae (budding yeast) nuclear endoribonuclease and homolog of human Drosha with well-characterized roles in the processing of ncRNAs. The enzyme recognizes and cleaves double-stranded RNA stems containing a terminal tetraloop with an AGNN consensus sequence. However, the scope and consequence of its function in mRNA degradation has heretofore been unclear. Previous studies have …