Digital Commons Network^™

Extravascular Factor Ix: A Semicentennial Narrative Review, Tvisha Subhasish, Christopher R. Reed

Student Publications

Coagulation factor IX (FIX) is a serine protease that is crucial for normal hemostasis in vertebrates. Unlike other soluble vitamin K-dependent procoagulant enzymes, there is an “extravascular reservoir” of FIX in various tissues. The extravasation of FIX and its subsequent maintenance outside of circulation have long been attributed to its ability to bind collagen IV. This property is conferred by a short, specialized region of its phospholipid-binding gamma-carboxyglutamic acid (Gla) domain. Collagen IV is a nonfibrillar extracellular protein found primarily in basement membranes that assembles into sheet-like supportive structures around blood vessels and epithelia, providing a convenient scaffold for this …

Analyzing The Effects Of Biodegradable Plastic Fragments On Maize Development And Defense Signaling, Ulysses Hampton

Theses

As plastic use shifts from non-degradable to biodegradable materials, the effects of biodegradable plastic fragments on crop physiology remain unclear. This study investigated how biodegradable plastic fragments influence maize development, transpiration, and defense signaling. Among five plastic types tested, poly(butylene adipate-co-terephthalate) (PBAT), polyhydroxyalkanoates (PHA), polycaprolactone (PCL), polylactic acid (PLA), and thermoplastic starch (TPS). PBAT and TPS showed the most significant effects and were selected for further oxylipin analysis. Results indicate that biodegradable plastic fragments can alter oxylipin signaling pathways in subtle but meaningful ways, suggesting that these materials are not inherently risk-free alternatives to conventional plastics.

Ai-Assisted, Multi-Layer Enhancement Of The Data Delivery Index (Ddi) For Fitness-For-Purpose Data Quality Assessment, Batool Abuhlaiqa

Theses

High-quality data is fundamental to the production of reliable official statistics and evidence-based decision-making. While deterministic data quality assessment frameworks provide transparent, consistent, and reproducible evaluations, they are limited in accommodating the intended statistical use of data and identifying complex quality issues beyond predefined validation rules. As administrative datasets continue to increase in volume, diversity, and complexity, there is a growing need for governance-oriented approaches that enhance existing quality assessment practices without compromising transparency, accountability, or consistency. This research proposes and evaluates an AI-assisted multi-layer enhancement of the DDI, a governance-oriented data quality assessment framework developed by SCAD. The proposed …

Radical Regionalism: Integrating Historical Vernacular Wisdom With Modern Building Science For Resilient Envelope Design, Barbara Patricia Montano

Theses

This thesis investigates how vernacular environmental knowledge can be integrated with contemporary building science to inform climate-responsive residential building-envelope design. In response to the limitations of standardized construction approaches across diverse climatic regions, the research proposes Radical Regionalism, a framework that combines vernacular environmental principles, passive design strategies, sustainable material selection, building-envelope science, and resilience considerations within a performance-based design methodology. A comparative climate-based modeling methodology is applied to a representative single-family residential prototype across four contrasting United States climatic contexts: Miami, Florida (hot-humid); Phoenix, Arizona (hot-dry); Boston, Massachusetts (cold-humid); and Denver, Colorado (cold-dry). Representative conventional code-minimum wall assemblies are …

Modeling Active Galactic Nuclei Spectra Of Supermassive To Hypermassive Black Holes, Priti Finavia

Theses

It is generally believed that most massive galaxies host supermassive black holes (SMBHs) at their centers, with masses ranging from 10^6 -10^{10} M☉. During phases of rapid accretion, these SMBHs emit electromagnetic radiation across the entire spectrum, resulting in luminous active galactic nuclei (AGN). An open question is whether SMBHs can grow to exceed 10^{10} M☉ through continued accretion and successive mergers, potentially forming hypermassive black holes (HMBHs).  The broad line region (BLR) consists of dense gas clouds located within sub-parsec distances of the central SMBH. The clouds are photoionized by continuum radiation emitted by the accretion disk and hot …

Puzzles & Frames: Exploring Motion Graphics In Thriller Movie Poster Design, Xingyu Xiao

Theses

This thesis explores how motion graphics can expand the role of traditional movie posters and create more engaging visual communication experiences. The project began with an observation that static posters displayed in busy campus environments can easily be overlooked. This led to the central question of how motion graphics can make traditional movie posters more visually engaging and effective in campus environments. To investigate this question, I developed a series of dynamic thriller movie posters that combine traditional graphic design elements—including typography, composition, imagery, abstraction, and visual hierarchy—with motion. The design process developed through several stages of experimentation. Early studies …

Beyond Conventional Construction A Sustainability Assessment Of 3d-Printed Concrete For Multi-Family Housing, Jennifer Candelier

Theses

The construction industry continues to face significant challenges, including labor shortages, increasing housing demand, rising material costs, and pressure to reduce environmental impacts. Three-dimensional printed concrete (3DPC) has emerged as a potential alternative to conventional construction methods by improving automation, material efficiency, and construction productivity. However, existing research has focused primarily on single-family applications, leaving limited understanding of its feasibility for multi-family residential construction. This study evaluates whether 3D printed concrete can become a standardized construction method for multi-family residential buildings by comparing it with conventional concrete masonry unit (CMU) construction. A comparative, performance-based methodology was developed using two equivalent …

What Representations Preserve: Information-Theoretic And Geometric Conditions For Out-Of-Distribution And Hallucination Detection, Hong Yang

Theses

Models deployed outside controlled settings encounter inputs unlike their training data and may generate outputs unsupported by what they learned. A reliable system should recognize these cases. Out-of-distribution detection and hallucination detection are usually studied separately, but both depend on the same condition: the model's representation must retain the information that distinguishes an anomalous case from an ordinary one. If training never captures that information, or later suppresses it, no downstream detector can recover it. We study this condition from two complementary perspectives. Mutual information measures how much information about the relevant distinction remains in a representation, while feature-space geometry …

Comparing Initial Data For Binary Neutron Star Mergers With Different Equations Of State, Aarati Nandre

Theses

Binary neutron star (BNS) mergers are an important tool for studying nuclear matter at extreme densities inaccessible to laboratory experiments. The equation of state (EOS) of this nuclear matter affects the inspiral dynamics, remnant properties, and the resulting gravitational-wave signal, but remains only weakly constrained at supranuclear densities. The observation of  GW170817 provided observational constraints on the EOS and established multimessenger astrophysics as a probe of dense matter. Simulating BNS mergers across a range of EOSs and comparing the resulting observables against detections helps narrowing this uncertainty further, and is the broader motivation for this thesis. General relativistic magnetohydrodynamic simulations …

Biochar-Derived Ethylene Scavengers For The Preservation Of Bananas, Morgan Samson

Theses

Ethylene regulates the rapid ripening of numerous climacteric fruits (e.g., banana, tomato, mango, and avocado). Minimization of ethylene formation and action in fruits during harvest or at any stage along the supply chain has become an important approach to prolong storage periods and minimize postharvest losses. Active packaging with ethylene scavengers has been proven to extend the shelf life of climacteric fruits; however, a cost-effective and sustainable solution is needed. Biochar-derived ethylene scavengers offer a promising approach to minimize postharvest losses, along with the valorization of abundant organic residues. This study produced and characterized biochars from two different feedstocks (i.e., …

Development And Characterization Of Pellet-Printable Pla/Waste Tire Rubber Composites For 4d Additive Manufacturing, Deepak Haresh Devjani

Theses

Waste tire rubber (WTR) presents a persistent environmental challenge but also offers potential as a functional filler for polymer-based additive manufacturing. This study developed and characterized pellet-printable polylactic acid (PLA)/WTR composites for conventional and 4D printing. WTR powder was treated using a nominal 6 wt% sodium hydroxide solution and incorporated into PLA at 0, 1, 3, 5, and 7 wt%. The formulations were mechanically premixed, melt-compounded, pelletized, and processed by fused granulate fabrication under constant printing conditions. Optical microscopy, thermogravimetric analysis, differential scanning calorimetry, tensile, compression, and impact testing were conducted. Shape-memory performance was evaluated by compressing grid-infilled specimens to …

Personalization And Generalization In Machine Learning For Affective Ai, Rajesh Titung

Theses

Human emotional communication involves subtle, low-intensity, and context-dependent expressions influenced by sociocultural and interpersonal factors. Their inherent ambiguity and variability create heterogeneous data distributions, making affective phenomena difficult to model in naturalistic settings where expressions differ from exaggerated affect behaviors in acted environments. Affective AI faces the fundamental challenge of balancing personalization, which captures individual nuances, with generalization, which ensures robustness of affective AI systems across individuals. Traditional centralized models emphasizing generalization often fail to capture fine-grained expressive heterogeneity, while fully personalized models improve system performance for individuals but lack transferability and robustness. The central task is thus to develop …

Design Of A Continuum Robot Test Bed Utilizing Model-Free Sliding Mode Control, Joseph Paul Streib

Theses

Continuum robots are a class of continually deformable robots inspired by snakes and tentacles that are commonly used in medical, search and rescue, and exploration applications. The robots are highly nonlinear and difficult to accurately model and control. Precise control of the pose of a continuum robot is typically reliant upon a system model. This work introduces a novel model free control algorithm for continuum robots that only relies upon the robot’s position in task space. The derived controller is built upon the foundation of a preexisting model free sliding mode controller and the q-state parameterized piecewise constant curvature kinematic …

Capital Cities: The Intersection Of Power And Protest Urban Planning And Civic Design In Brasília And Washington, D.C., Noah Benjamin Gill

Theses

The physical environments of capital cities play a critical role in shaping how citizens interact with governmental power, particularly during moments of political unrest, protest, and democratic conflict. As both symbolic representations of national identity and functional centers of government, these urban landscapes influence how citizens approach, occupy, and confront civic institutions through their planning, architectural form, circulation networks, and spatial organization. Government buildings, public plazas, monumental landscapes, and civic axes do more than provide settings for political activity; they actively shape patterns of movement, visibility, accessibility, and control. The design of these spaces influences not only how democratic institutions …

Engineering Materials Function With Reconfigurable Colloids, Laura Galeano Tirado

Theses

The function of a material is defined not only by its chemical composition, but also by the structural organization of its constituents across multiple length scales, from the architecture of individual building blocks to their collective arrangement. Developing strategies to access, engineer, and reconfigure that structure on demand represents a central opportunity in the design of adaptive materials. Here, we present a thermoresponsive polymer-colloid platform that enables high-precision tuning of colloidal structures using only thermal stimuli. Rather than adsorbing to the surface, our polymers diffuse inside organosilica colloids to reshape them from within, allowing continuous modulation of their size, shape, …

Semiconductor Laser Calibration Through Photonic Chip With Microcontroller Driven Wavelength Inference, Clayton Acheson

Theses

Integrated Silicon Photonics leverages light-speed operation with lower power and higher data rates than electronic counterparts. To achieve this, light is sent through a silicon circuit, where it is manipulated to perform various operations. Primarily, the light for these circuits comes from laser sources. Semiconductor lasers are typically used for their small form factor and ability to be heterogeneously integrated into larger, more complex systems. Because the optical phase and wavelength of light respond to minute changes in local refractive index, light is increasingly used for high-sensitivity sensing in integrated photonic circuit applications. As such, schemes that integrate the laser …

A Best-Practice And Risk-Assessment Framework For Auditable Ai Integration In Uae Government Socs, Nasser Hassan Nasser Abdulrazaq Alrazooqi

Theses

The growing use of artificial intelligence and generative AI in security operations centres  have the ability to improve alert triage, investigation, threat-intelligence enrichment,  and incident response. It also introduces governance risks including explainability, data  leakage, prompt injection, model lifecycle management, human oversight, and the  traceability of AI-assisted decisions. This study has developed a best-practice and risk assessment framework for the auditable integration of AI in UAE’s governmental SOCs.  The research follows a qualitative and practitioner-informed documentary analysis.  Publicly available UAE cybersecurity policies, internationally recognised NIST and  ISO/IEC standards, academic literature, industry guidance and compliance  publications were reviewed. Moreover, they were …

Multimodal Brain-Computer Interface For Real-Scene Object Selection And Shared Robotic Arm Control, Mohammad Keshtkar

Theses

Due to the limited bandwidth and reliability of non-invasive electroencephalography (EEG)-based brain–computer interface (BCI) systems, it is difficult to control a six-degree-of-freedom (6-DoF) robotic arm using such a system. This thesis proposes a multimodal BCI system for controlling a robotic arm that divides control into three stages: initiating the task through right-hand motor imagery (MI), selecting an object of interest from a real scene using steady-state visual evoked potentials (SSVEPs) and webcam-based eye tracking, and autonomously performing the pick-and-drop task using a WidowX 250 robotic arm. Two separate offline experiments, each involving ten participants, were performed to test the SSVEP …

Enhancing Net-Zero Strategies At Rit Dubai Campus Through Life Cycle Assessment, Razan Ali

Theses

Net-zero commitments are pushing higher education institutions to measure their environmental impact more rigorously. RIT Dubai has aligned its sustainability targets with the UAE Net Zero 2050 initiative, and earlier greenhouse gas reporting identified commuting and electricity as the campus’s dominant emission sources, with transportation modelled only from city-level estimates. This thesis develops an individual-level, use-phase Life Cycle Assessment of transportation at RIT Dubai across the entire campus community of 2,795 members in seven segments: local and international students, faculty and staff, and the contracted service staff who travel to campus daily. A transportation Life Cycle Inventory was built from …

Ikaros: See Through Time, Aisha F. A. Alnouri

Theses

Conventional heritage interpretation often relies on static signage, creating an "information void" where physical ruins sit uncontextualized. This thesis addresses this issue by proposing an interactive spatial information system designed to dynamically display, and contextualize architectural heritage in real time. Designed as a global framework, Failaka Island in Kuwait serves as the primary case study, driven by a personal cultural connection and the need to bridge the island's post-war generational disconnect. Positioned at the intersection of information design, interactive media, and spatial visualization, the system, Ikaros, utilizes Hellenistic Temple B, a 3rd-century BCE sanctuary, as its core testbed. The touchscreen …

Blood-Based Circular Rnas For Early Diagnosis Of Alzheimer's Disease, Bridget Phillips, Jessie Sanford, Menghan Liu, Matt Johnson, Katherine Gong, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Nicholas Sykora, John Budde, John C Morris, Joel S Perlmutter, Paul T Kotzbauer, Richard J Perrin, Laura Ibanez, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Detection of Alzheimer's disease (AD) before the development of clinical symptoms is critical for enabling the use of new treatments. Circular RNAs (circRNAs) are highly stable non-coding RNAs enriched in the brain that can cross the blood-brain barrier. Here, analyzing blood data from 1,221 individuals with AD and healthy individuals, we identified 34 circRNAs associated with AD status. A predictive model including these 34 circRNAs was comparable to plasma phosphorylated Tau-217 (pTau217) in classifying AD based on biomarker-confirmed (amyloid-β and Tau) status and replicated in independent samples from the Knight-Alzheimer Disease Research Center (n = 551: 76 AD, 475 cognitively …

Sez6-Targeting Antibody-Drug Conjugate Abbv-706 In Advanced Small Cell Lung Cancer And Solid Tumors: A Phase 1 Trial, Lauren Averett Byers, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

Seizure-related homolog 6 (SEZ6) is expressed in small cell lung cancer (SCLC) and neuroendocrine neoplasms. In an open label, phase 1 trial, ABBV-706, an antibody-drug conjugate with a SEZ6-directed antibody linked to topoisomerase-1 inhibitor (Top1i), was administered intravenously every 3 weeks (Q3W) to 288 patients with advanced solid tumors; 240 received monotherapy, including 124 with relapsed/refractory (R/R) SCLC. Primary objectives of dose escalation (part 1, advanced solid tumors), dose optimization and expansion (part 2, R/R SCLC only) and dose expansion (part 4, central nervous system tumors and high-grade neuroendocrine neoplasms only) were to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity …

Biological Aging And Generational Shifts In Early-Onset Cancer Risk, Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye Oduyale, Jason D Buenrostro, Ramaswamy Govindan, Yin Cao

2020-Current year OA Pubs

Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965-1974 versus 1950-1954, and was associated with early-onset solid cancer risk (hazard ratio (HR)

Achilles Tendon Injuries In Major League Soccer: A 10-Year Analysis Of Injury Rate, Return To Play, And Performance Metrics, Brian Forsythe, Catherine Hand, Francis Hand, Henry Eilen, Matthew Varano, Jared Sasaki, Camden Bohn, Anne Timmermann, Lauren Fertig, Eric Giza, Robert H Brophy, Bert Mandelbaum, Kirk Mccullough

2020-Current year OA Pubs

BACKGROUND: Injuries to the Achilles tendon, such as tears or ruptures, are commonly observed among elite athletes. These injuries can be debilitating for professional soccer players, leading to prolonged recovery and potential performance declines.

PURPOSE: To investigate the annual incidence, return-to-play (RTP) duration, and postinjury performance outcomes of Major League Soccer (MLS) players who sustained Achilles tendon injuries from 2010 to 2021.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: This retrospective matched-cohort study evaluated MLS players with Achilles tendon injuries from 2010 to 2021, identified through the MLS Injury Surveillance database, and compared outcomes, including RTP duration, between …

Effects Of Concurrent Neuropathologies With Alzheimer Disease Neuropathologic Change On Cognitive Decline: Minimal Impact Of Vascular Brain Injury Compared With Other Combinations, Sarah M Yasuda, Charles Mock, Kathryn Gauthreaux, Kwun C G Chan, C Dirk Keene, Jessica E Culhane, Yen-Chi Chen, Walter Kukull

2020-Current year OA Pubs

We examined cognitive changes associated with several neuropathologic entities, alone and in combination. We studied 808 participants from the National Alzheimer's Coordinating Center to assess associations between neuropathologic diagnoses (from autopsy) and neuropsychologic test scores (trajectories over time for 5 domains: overall cognition, episodic memory, attention, language, executive function). Neuropathologies included: Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), vascular brain injury (VBI), and limbic-predominant age-related TDP43 encephalopathy neuropathologic change (LATE-NC). Using linear mixed-effects models, we examined trajectories of cognitive decline for ADNC alone compared to ADNC plus LBD, VBI, or LATE-NC. We also examined differences between observed trajectories …

A Multistate Analysis Of Longitudinal Care Outcomes Among People Newly Linked To Human Immunodeficiency Virus Care In Missouri, Aditi Ramakrishnan, Daniel Vo, Ernie-Paul Barrette, Rachel M Presti, William G Powderly, Anne Trolard, Corey Grejtak-Heaps, Elvin H Geng, Aaloke Mody, Lindsey M Filiatreau

2020-Current year OA Pubs

BACKGROUND: Advancing the HIV response in Missouri, an Ending the HIV Epidemic priority state, requires stronger characterization of treatment gaps. Routine cross-sectional reporting may fail to capture important gaps in care that longitudinal methods can reveal.

METHODS: We characterized clinic engagement and viral suppression among people with Human Immunodeficiency Virus (HIV) aged ≥18 years who were newly linked to clinic in St Louis, Missouri, between 1 January 2015 and 15 March 2020. Using multistate analytic methods that capture change over time, we estimated the prevalence of individuals in 9 mutually exclusive and exhaustive states over 3 years following linkage to …

Financial Toxicity And Cost-Related Imaging Nonadherence In Pediatric Outpatient Imaging, Shireen E Hayatghaibi, Gregory L Jordan, Tucker Hansen, Amy E Ensing, Aditi Gupta, Evan A Mihalakakos, Bin Zhang, Pradipta Debnath, Carrie C Coughlin

2020-Current year OA Pubs

RATIONALE AND OBJECTIVES: Financial toxicity, defined as the financial burden and stress experienced due to medical costs, is increasingly recognized as a key patient-reported outcome and has been linked to cost-related non-adherence in adult populations. However, its prevalence and impact in pediatric imaging are unknown. We examined the prevalence and predictors of financial toxicity among families of children undergoing outpatient imaging and its association with imaging non-adherence.

MATERIALS AND METHODS: We conducted a prospective cross-sectional survey of parental caregivers of children (< 18 years of age) undergoing outpatient imaging at two free standing children's hospitals in the U.S. (July 2024-May 2025). Financial toxicity was measured using the adapted FACIT-COST instrument and scores < 26 indicated high financial toxicity. Multivariable logistic regression examined associations between family characteristics and high financial toxicity.

RESULTS: Among 399 caregivers, the mean FACIT-COST score was 24.6 (SD 10.2), and 49% were categorized as having …

Kirschner Wire Skeletal Fixation In The Hand And Wrist: Risk Of Infection And Predictors Of Progression To Major Complications, Mitchell S Mologne, Julia M Perugini, Nicholas A Calotta, Lindley B Wall, Charles A Goldfarb

2020-Current year OA Pubs

PURPOSE: Kirschner wire (K-wire) infections continue to be a challenge in hand surgery. Our purpose was to quantify the frequency of K-wire site infections of the hand and wrist, to tabulate major and minor infectious manifestations, to identify factors that may predispose a patient to major complications, and to generate an updated algorithm for prognostication and treatment of K-wire site infections.

METHODS: Patients treated with K-wires in the fingers, hand, and wrist who developed infections between 2018 and 2024 at our institution were identified. Information regarding patient factors, injury, treatment, and subsequent infectious complications was collected. Variables from single variable …

Language And Sound Exposure Across Neonatal Intensive Care Hospitalization And Relationships With Early Outcome, R Pineda, L J Woodward, Z A Vesoulis, C D Smyser, T E Inder, A M Mathur, B L Schlaggar

2020-Current year OA Pubs

OBJECTIVES: Examine relationships between quantitative measures of language and sound exposure in the NICU and infant neurobehavior.

STUDY DESIGN: Sixty-four preterm infants (≤28 weeks of gestation) had language and sound exposure measured across four time points: within two weeks of birth and at 30, 34, and 35-41 weeks postmenstrual age (PMA). Neurobehavior was assessed at 35-41 weeks PMA using the NICU Network Neurobehavioral Scales.

RESULTS: Higher average decibel levels in the NICU environment were associated with lower infant orientation scores (p = 0.04, β = -0.33). Higher peak decibel levels were associated with greater hypertonia (p = 0.01, β = …

Molecular Basis For The Regulation Of Membrane Proteins Through Preferential Lipid Solvation, Nathan Bernhardt, Tugba N Ozturk, Shan Zhang, Noah Schwartz, Rahul Chadda, Alejandro Gil-Ley, Janice L Robertson, José D Faraldo-Gómez

2020-Current year OA Pubs

The mechanism by which lipids regulate membrane proteins remains an open question. While many protein structures reveal associated lipids, neither binding nor regulatory mechanisms can be gleaned from frozen static snapshots, as these processes occur in the context of a dynamic membrane at equilibrium. In this study, we combine single-molecule experiments with computational analyses of lipid dynamics and lipid-solvation energetics to understand how changes in the lipid composition of the membrane influence the dimerization of the CLC-ec1 chloride/proton antiporter. We find this influence does not result from long-lived lipid binding at specific sites, but instead from an inherently dynamic effect …