Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 188101 - 188130 of 5160079

Full-Text Articles in Entire DC Network

Box Of Criminals, Jenna Reynolds May 2025

Box Of Criminals, Jenna Reynolds

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Jenna Reynolds is a Senior English Writing major. She has written for AMWR in the past and has also written for the DePauw stage (Romeo and Juliet at Bridgerton).


I Write For Them And Sundays, Audrey Ickes May 2025

I Write For Them And Sundays, Audrey Ickes

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Audrey Ickes is a Senior English-Writing major and History and Communications double minor. Flip to page 31 to see the rest of her credentials or page 23 to find out why she writes whether she likes to or not.


The Space Between: Engaging And Withholding The Self, Maya Mcdonald May 2025

The Space Between: Engaging And Withholding The Self, Maya Mcdonald

All Theses

This thesis, The Space Between: Engaging and Withholding the Self, documents my journey in understanding the self through the act of oil-painted self-portraiture. Through an exploration of eye contact, body language, non-performative representations of self, and the tension between engagement and detachment, this body of work examines the complexities of visibility, agency, and self-perception. Using my own body as both subject and metaphor, I investigate the interplay between revealing and withholding, questioning the boundaries between what is seen and what remains obscured. Blending classical figure painting techniques with abstracted elements, my work engages in a dialogue between tradition and …


Untethered And Unraveled: Isolated Motherhood In The Liminal Stage, Ashton K. Wronikowski May 2025

Untethered And Unraveled: Isolated Motherhood In The Liminal Stage, Ashton K. Wronikowski

All Theses

In examining Kate Chopin’s The Awakening alongside anthropologic theories of liminality, this paper examines the becoming women traverse as they transition between various social roles: girl, woman, mother. Edna is a maternal character attempting to unweave herself from her roles as mother and wife, and she finds this desire to go backwards to the freedom she experienced as a girl is proven to be impossible. The unmooring of her psyche and her subsequent suicide is indicative of a failure, not of her own accord, but in the social preparation and support she receives within her new identity. Social anthropologists further …


Cloud-Native Mucad For Design Reviews, Emily C. Petty May 2025

Cloud-Native Mucad For Design Reviews, Emily C. Petty

All Theses

This research explores the potential of a cloud-native multi-user computer-aided design (MUCAD) system to improve communication and efficiency during engineering design reviews and shorten the design timeline for military tools. First, a literature review is used to generate a list of thirty-five collaboration-oriented requirements that aim to ensure concurrency, annotations, heterogeneity, security, IP protection, version control, and viewing within a MUCAD system. A comparative evaluation of existing collaborative CAD system architectures, including cloud-native, cloud-enabled, and a single-user system with external file sharing, is conducted to determine how well each system architecture fulfills the generated collaboration-oriented requirements. Following this, a survey …


An Examination Of The Lived Experiences Of Black Women Instructional Coaches (K-12), Courtney Tate May 2025

An Examination Of The Lived Experiences Of Black Women Instructional Coaches (K-12), Courtney Tate

All Dissertations

The underrepresentation of Black women notably impacts the landscape of educational leadership as a result of a predominantly White workforce within the teaching profession (N. N. Johnson & Fournillier, 2021). This inequity not only highlights systemic inefficiencies as evidenced by worsening educational experiences for African American students following Brown v. BOE but also underscores the silence within studies exploring the experiences of Black women faculty in instructional leadership roles (Brown, 2005; Foster, 2005; N. N. Johnson, 2024; N. N. Johnson & Fournillier, 2021). The role of instructional coaches in shaping teacher practice positions them as integral to instructional leadership; it …


Essays On Macroeconomics, Krishna Sharma May 2025

Essays On Macroeconomics, Krishna Sharma

All Dissertations

The first chapter examines the role of return migration in driving innovation within India’s tech startup ecosystem, using a novel dataset constructed from web scraping of startup profiles, LinkedIn data, and patent databases. By capturing founders’ international experience, education, and innovation outcomes, the analysis reveals that returnees significantly contribute to higher inno- vation levels, particularly through patent filings. Returnee-founded startups exhibit an 18% higher rate of patent filings compared to those led by locals. The study employs OLS, Poisson regression, Coarsened Exact Matching (CEM), and Instrumental Variables (IV) to address selection bias and endogeneity concerns. U.S. immigration policy changes provide …


The Great Animal Rights Debate: From The Past Into The Present, Dayna Wiley May 2025

The Great Animal Rights Debate: From The Past Into The Present, Dayna Wiley

Celebrating Scholarship and Creativity Day (2018-)

Animal rights are not a novel concept, and everyone has their own beliefs about where animals should fit into the hierarchy of life. Not so different from today, a debate occurred in the ancient world between the Stoics, represented by Aristotle, and Plutarch, with each questioning whether animals are capable of rational thought or feelings, and therefore whether they are deserving of justice. There is much to learn from the ancient world about the modern debate on animal rights, and there is a striking comparison between this ancient debate and the modern questions of animal rights. But how similar are …


Reading The Minoan "Sacral Knot", Rylie Owen May 2025

Reading The Minoan "Sacral Knot", Rylie Owen

Celebrating Scholarship and Creativity Day (2018-)

The sacral knot, a term first coined by Sir Arthur Evans, is an iconic symbol in Minoan iconography, but there is surprisingly little information about it. Various interpretations have been suggested regarding the meaning of this knot, the most popular and well-known being a religious function.There is no doubt that the so-called "sacral knot” had an important meaning in Bronze Age Greece, with a number of depictions showing the knot alongside other significant symbols, such as bulls, figure-of-eight shields, and lions. However, the knot also appears to function as a symbol on its own. This analysis draws from a compilation …


The Success Of Peer Education [Poster], Kaylee Van Pelt May 2025

The Success Of Peer Education [Poster], Kaylee Van Pelt

Graduation with Distinction Posters

No abstract provided.


Peer Tutoring Strategies For Science Major And Non-Major Undergraduate Students [Poster], Thomas Manternach May 2025

Peer Tutoring Strategies For Science Major And Non-Major Undergraduate Students [Poster], Thomas Manternach

Graduation with Distinction Posters

No abstract provided.


Guiding The Game: Peer Mentoring Approaches For First-Year Student-Athletes [Poster], Madison Carleton May 2025

Guiding The Game: Peer Mentoring Approaches For First-Year Student-Athletes [Poster], Madison Carleton

Graduation with Distinction Posters

No abstract provided.


Alpha-Smooth Muscle Actin-Expressing Dermal Sheath Cells Are A Major Cellular Contributor To Heterotopic Subcutaneous Ossifications In A Mouse Model Of Albright Hereditary Osteodystrophy., Patrick Mcmullan, Peter Maye, Sierra H Root, Qingfen Yang, Sarah Edie, David Rowe, Ivo Kalajzic, Emily L Germain-Lee May 2025

Alpha-Smooth Muscle Actin-Expressing Dermal Sheath Cells Are A Major Cellular Contributor To Heterotopic Subcutaneous Ossifications In A Mouse Model Of Albright Hereditary Osteodystrophy., Patrick Mcmullan, Peter Maye, Sierra H Root, Qingfen Yang, Sarah Edie, David Rowe, Ivo Kalajzic, Emily L Germain-Lee

Faculty Research 2025

Heterotopic ossifications (HOs) are the pathologic process by which bone inappropriately forms outside of the skeletal system. Despite HOs being a persistent clinical problem in the general population, there are no definitive strategies for their prevention and treatment due to a limited understanding of the cellular and molecular mechanisms contributing to lesion development. One disease in which the development of heterotopic subcutaneous ossifications (SCOs) leads to morbidity is Albright hereditary osteodystrophy (AHO). Albright hereditary osteodystrophy is caused by heterozygous inactivation of GNAS, the gene that encodes the α-stimulatory subunit (Gαs ) of G proteins. Previously, we had shown using our …


Deciphering The Longitudinal Trajectories Of Glioblastoma Ecosystems By Integrative Single-Cell Genomics., Avishay Spitzer, Kevin C Johnson, Masashi Nomura, Luciano Garofano, Djamel Nehar-Belaid, Noam Galili Darnell, Alissa C Greenwald, Lillian Bussema, Young Taek Oh, Frederick S Varn, Fulvio D'Angelo, Simon Gritsch, Kevin J Anderson, Simona Migliozzi, L Nicolas Gonzalez Castro, Tamrin Chowdhury, Nicolas Robine, Catherine Reeves, Jong Bae Park, Anuja Lipsa, Frank Hertel, Anna Golebiewska, Simone P Niclou, Labeeba Nusrat, Sorcha Kellet, Sunit Das, Hyo-Eun Moon, Sun Ha Paek, Franck Bielle, Alice Laurenge, Anna Luisa Di Stefano, Bertrand Mathon, Alberto Picca, Marc Sanson, Shota Tanaka, Nobuhito Saito, David M Ashley, Stephen T Keir, Keith L Ligon, Jason T Huse, W K Alfred Yung, Anna Lasorella, Antonio Iavarone, Roel G W Verhaak, Itay Tirosh, Mario L Suvà May 2025

Deciphering The Longitudinal Trajectories Of Glioblastoma Ecosystems By Integrative Single-Cell Genomics., Avishay Spitzer, Kevin C Johnson, Masashi Nomura, Luciano Garofano, Djamel Nehar-Belaid, Noam Galili Darnell, Alissa C Greenwald, Lillian Bussema, Young Taek Oh, Frederick S Varn, Fulvio D'Angelo, Simon Gritsch, Kevin J Anderson, Simona Migliozzi, L Nicolas Gonzalez Castro, Tamrin Chowdhury, Nicolas Robine, Catherine Reeves, Jong Bae Park, Anuja Lipsa, Frank Hertel, Anna Golebiewska, Simone P Niclou, Labeeba Nusrat, Sorcha Kellet, Sunit Das, Hyo-Eun Moon, Sun Ha Paek, Franck Bielle, Alice Laurenge, Anna Luisa Di Stefano, Bertrand Mathon, Alberto Picca, Marc Sanson, Shota Tanaka, Nobuhito Saito, David M Ashley, Stephen T Keir, Keith L Ligon, Jason T Huse, W K Alfred Yung, Anna Lasorella, Antonio Iavarone, Roel G W Verhaak, Itay Tirosh, Mario L Suvà

Faculty Research 2025

The evolution of isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) after standard-of-care therapy remains poorly understood. Here we analyzed matched primary and recurrent GBMs from 59 patients using single-nucleus RNA sequencing and bulk DNA sequencing, assessing the longitudinal evolution of the GBM ecosystem across layers of cellular and molecular heterogeneity. The most consistent change was a lower malignant cell fraction at recurrence and a reciprocal increase in glial and neuronal cell types in the tumor microenvironment (TME). The predominant malignant cell state differed between most matched pairs, but no states were exclusive or highly enriched in either time point, nor was there …


Complete Sequencing Of Ape Genomes., Dongahn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A Logsdon, Steven J Solar, Dmitry Antipov, Brandon D Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M Storer, Jiadong Lin, Abigail N Sequeira, Riley J Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R Beck, Arjun Biddanda, Matthew Borchers, Gerard G Bouffard, Emry Brannan, Shelise Y Brooks, Lucia Carbone, Laura Carrel, Agnes P Chan, Juyun Crawford, Mark Diekhans, Eric Engelbrecht, Cedric Feschotte, Giulio Formenti, Gage H Garcia, Luciana De Gennaro, David Gilbert, Richard E Green, Andrea Guarracino, Ishaan Gupta, Diana Haddad, Junmin Han, Robert S Harris, Gabrielle A Hartley, William T Harvey, Michael Hiller, Kendra Hoekzema, Marlys L Houck, Hyeonsoo Jeong, Kaivan Kamali, Manolis Kellis, Bryce Kille, Chul Lee, Youngho Lee, William Lees, Alexandra P Lewis, Qiuhui Li, Mark Loftus, Yong Hwee Eddie Loh, Hailey Loucks, Jian Ma, Yafei Mao, Juan F I Martinez, Patrick Masterson, Rajiv C Mccoy, Barbara Mcgrath, Sean Mckinney, Britta S Meyer, Karen H Miga, Saswat K Mohanty, Katherine M Munson, Karol Pal, Matt Pennell, Pavel A Pevzner, David Porubsky, Tamara Potapova, Francisca R Ringeling, Joana L Rocha, Oliver A Ryder, Samuel Sacco, Swati Saha, Takayo Sasaki, Michael C Schatz, Nicholas J Schork, Cole Shanks, Linnéa Smeds, Dongmin R Son, Cynthia Steiner, Alexander P Sweeten, Michael G Tassia, Françoise Thibaud-Nissen, Edmundo Torres-González, Mihir Trivedi, Wenjie Wei, Julie Wertz, Muyu Yang, Panpan Zhang, Shilong Zhang, Yang Zhang, Zhenmiao Zhang, Sarah A Zhao, Yixin Zhu, Erich D Jarvis, Jennifer L Gerton, Iker Rivas-González, Benedict Paten, Zachary A Szpiech, Christian D Huber, Tobias L Lenz, Miriam K Konkel, Soojin V Yi, Stefan Canzar, Corey T Watson, Peter H Sudmant, Erin Molloy, Erik Garrison, Craig B Lowe, Mario Ventura, Rachel J O'Neill, Sergey Koren, Kateryna D Makova, Adam M Phillippy, Evan E Eichler May 2025

Complete Sequencing Of Ape Genomes., Dongahn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A Logsdon, Steven J Solar, Dmitry Antipov, Brandon D Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M Storer, Jiadong Lin, Abigail N Sequeira, Riley J Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R Beck, Arjun Biddanda, Matthew Borchers, Gerard G Bouffard, Emry Brannan, Shelise Y Brooks, Lucia Carbone, Laura Carrel, Agnes P Chan, Juyun Crawford, Mark Diekhans, Eric Engelbrecht, Cedric Feschotte, Giulio Formenti, Gage H Garcia, Luciana De Gennaro, David Gilbert, Richard E Green, Andrea Guarracino, Ishaan Gupta, Diana Haddad, Junmin Han, Robert S Harris, Gabrielle A Hartley, William T Harvey, Michael Hiller, Kendra Hoekzema, Marlys L Houck, Hyeonsoo Jeong, Kaivan Kamali, Manolis Kellis, Bryce Kille, Chul Lee, Youngho Lee, William Lees, Alexandra P Lewis, Qiuhui Li, Mark Loftus, Yong Hwee Eddie Loh, Hailey Loucks, Jian Ma, Yafei Mao, Juan F I Martinez, Patrick Masterson, Rajiv C Mccoy, Barbara Mcgrath, Sean Mckinney, Britta S Meyer, Karen H Miga, Saswat K Mohanty, Katherine M Munson, Karol Pal, Matt Pennell, Pavel A Pevzner, David Porubsky, Tamara Potapova, Francisca R Ringeling, Joana L Rocha, Oliver A Ryder, Samuel Sacco, Swati Saha, Takayo Sasaki, Michael C Schatz, Nicholas J Schork, Cole Shanks, Linnéa Smeds, Dongmin R Son, Cynthia Steiner, Alexander P Sweeten, Michael G Tassia, Françoise Thibaud-Nissen, Edmundo Torres-González, Mihir Trivedi, Wenjie Wei, Julie Wertz, Muyu Yang, Panpan Zhang, Shilong Zhang, Yang Zhang, Zhenmiao Zhang, Sarah A Zhao, Yixin Zhu, Erich D Jarvis, Jennifer L Gerton, Iker Rivas-González, Benedict Paten, Zachary A Szpiech, Christian D Huber, Tobias L Lenz, Miriam K Konkel, Soojin V Yi, Stefan Canzar, Corey T Watson, Peter H Sudmant, Erin Molloy, Erik Garrison, Craig B Lowe, Mario Ventura, Rachel J O'Neill, Sergey Koren, Kateryna D Makova, Adam M Phillippy, Evan E Eichler

Faculty Research 2025

The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies. Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (< 1 error in 2.7 megabases) and completely sequence 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, to provide in-depth evolutionary insights. Comparative analyses enabled investigations of the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference genome. Such regions include newly minted gene families in lineage-specific segmental duplications, centromeric DNA, acrocentric chromosomes and subterminal heterochromatin. This resource serves as a comprehensive baseline for future evolutionary studies of humans and our closest living ape relatives.


Clonal Dynamics And Somatic Evolution Of Haematopoiesis In Mouse., Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, Caroline Watson, Matthew J Yousefzadeh, Duy Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel Leongamornlert, Emily Mitchell, Marcus A Florez, Krzysztof Sosnowski, Rogelio Aguilar, Alejandra Martell, Anna Guzman, David E Harrison, Laura J Niedernhofer, Katherine Y King, Peter J Campbell, Jamie Blundell, Margaret A Goodell, Jyoti Nangalia May 2025

Clonal Dynamics And Somatic Evolution Of Haematopoiesis In Mouse., Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, Caroline Watson, Matthew J Yousefzadeh, Duy Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel Leongamornlert, Emily Mitchell, Marcus A Florez, Krzysztof Sosnowski, Rogelio Aguilar, Alejandra Martell, Anna Guzman, David E Harrison, Laura J Niedernhofer, Katherine Y King, Peter J Campbell, Jamie Blundell, Margaret A Goodell, Jyoti Nangalia

Faculty Research 2025

Haematopoietic stem cells maintain blood production throughout life1 . Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse stem cells and progenitors accrue approximately 45 somatic mutations per year, a rate only approximately threefold greater than human progenitors despite the vastly different organismal sizes and lifespans. Phylogenetic patterns show that stem and multipotent progenitor cell pools are established during embryogenesis, after which they …


Systematic Ocular Phenotyping Of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies., Andrew Briere, Peter Vo, Benjamin Yang, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Steve D M Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D'Souza, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Yann Hérault, Martin Hrabe De Angelis, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen L. Svenson, Masaru Tamura, Heather Tolentino, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Louise Lanoue, K C Kent Lloyd, Brian C Leonard, Michel J Roux, Colin Mckerlie, Ala Moshiri May 2025

Systematic Ocular Phenotyping Of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies., Andrew Briere, Peter Vo, Benjamin Yang, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Steve D M Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D'Souza, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Yann Hérault, Martin Hrabe De Angelis, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen L. Svenson, Masaru Tamura, Heather Tolentino, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Louise Lanoue, K C Kent Lloyd, Brian C Leonard, Michel J Roux, Colin Mckerlie, Ala Moshiri

Faculty Research 2025

PURPOSE: This study investigates genes contributing to late-adult corneal dystrophies (LACDs) in aged mice, with potential implications for late-onset corneal dystrophies (CDs) in humans.

METHODS: The International Mouse Phenotyping Consortium (IMPC) database, containing data from 8901 knockout mouse lines, was filtered to include late-adult mice (49+ weeks) with significant (P < 0.0001) CD phenotypes. Candidate genes were mapped to human orthologs using the Mouse Genome Informatics group, with expression analyzed via PLAE and a literature review for prior CD associations. Comparative analyses of LACD genes from IMPC and established human CD genes from IC3D included protein interactions (STRING), biological processes (PANTHER), and molecular pathways (KEGG).

RESULTS: Analysis identified 14 genes linked to late-adult abnormal corneal phenotypes. Of these, 2 genes were previously associated with CDs in humans, while 12 were novel. Seven of the 14 genes (50%) were expressed in the human cornea based on single-cell transcriptomics. Protein-protein interactions via STRING showed several significant interactions …


Challenges And Opportunities For Conceiving Genetically Diverse Sickle Cell Mice., Rafiou Agoro, Gary Churchill May 2025

Challenges And Opportunities For Conceiving Genetically Diverse Sickle Cell Mice., Rafiou Agoro, Gary Churchill

Faculty Research 2025

A milestone in sickle cell disease (SCD) therapeutics was achieved in December 2023 with the FDA-approved gene therapy for patients aged 12 years and older. However, these therapies may only suit a fraction of patients because of cost or health risks. A better understanding of SCD outcome heterogeneity is needed to propose patient-specific pharmacological interventions. To achieve this, humanized and genetically diverse mouse models are essential for associating candidate genotypes with specific hematological traits, organ function, and disease resilience. Here, we discuss the challenges and opportunities in developing genetically diverse sickle cell mice (GDS mice). These models are expected to …


An Intranasal Subunit Vaccine Induces Protective Systemic And Mucosal Antibody Immunity Against Respiratory Viruses In Mouse Models., Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen May 2025

An Intranasal Subunit Vaccine Induces Protective Systemic And Mucosal Antibody Immunity Against Respiratory Viruses In Mouse Models., Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Faculty Research 2025

Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked …


Evaluating The Feasibility Of Gene Replacement Strategies To Treat Mtrfr Deficiency., Samia L Pratt, Mariana Zarate-Mendez, Lidiia Koludarova, Sonja Jansson, Mikko Airavaara, Irena Hlushchuk, David Coleman, Caleb Heffner, Rita Horvath, Brendan J Battersby, Robert W. Burgess May 2025

Evaluating The Feasibility Of Gene Replacement Strategies To Treat Mtrfr Deficiency., Samia L Pratt, Mariana Zarate-Mendez, Lidiia Koludarova, Sonja Jansson, Mikko Airavaara, Irena Hlushchuk, David Coleman, Caleb Heffner, Rita Horvath, Brendan J Battersby, Robert W. Burgess

Faculty Research 2025

Mitochondrial translation release factor in rescue (MTRFR) catalyzes a termination step in protein synthesis, facilitating release of the nascent chain from mitoribosomes. Pathogenic variants in MTRFR cause MTRFR deficiency and are loss-of-function variants. Here, we tested gene replacement as a possible therapeutic strategy. A truncating mutation (K155*) was generated in mice; however, homozygotes die embryonically whereas mice heterozygous for this K155* allele are normal. We also generated transgenic strains expressing either wild-type human MTRFR or a partially functional MTRFR. Despite dose-dependent phenotypes from overexpression in vitro, neither transgene caused adverse effects in vivo. In K155* homozygous mice, the wild-type MTRFR …


Reimagining The Leader Behind The Badge: A Qualitative Study Examining Perceptions Of Law Enforcement Leadership From The Perspective Of Law Enforcement Officers, Willie Ng May 2025

Reimagining The Leader Behind The Badge: A Qualitative Study Examining Perceptions Of Law Enforcement Leadership From The Perspective Of Law Enforcement Officers, Willie Ng

Theses & Dissertations

This study explores the influence of leadership practices within law enforcement on the professional journey, job performance, and personal well-being of a career officer with over 30 years in the field. Set against a backdrop of evolving societal expectations and public scrutiny, the research investigates how entrenched leadership practices impact both individual experiences and the broader organizational culture within law enforcement. Key themes include outdated hierarchical practices, declining public trust, and resistance to innovation. These themes are examined using the new professionalism model, which emphasizes transparency, accountability, legitimacy, and innovation as essential leadership principles in modern policing (Bass & Avolio, …


#Teachersoftiktok - From Hashtags To Habits: Social Media's Influence On Teacher Identity, Practice, And The Role Of Teacher Preparation Programs (Chapter From Exploration Of K-12 Teaching And Learning Teacher Educators), Martha A. Wilkins, Danielle Ligocki May 2025

#Teachersoftiktok - From Hashtags To Habits: Social Media's Influence On Teacher Identity, Practice, And The Role Of Teacher Preparation Programs (Chapter From Exploration Of K-12 Teaching And Learning Teacher Educators), Martha A. Wilkins, Danielle Ligocki

Education Faculty Books/Book Chapters

Social media, particularly TikTok, has become a major influence on pre-service teachers (PSTs), shaping their professional identity, pedagogical expectations, and instructional decision-making. While TikTok offers networking and inspiration, its algorithm-driven content prioritizes entertainment over evidence-based pedagogy, reinforcing idealized, oversimplified, and commercialized portrayals of teaching. Many PSTs consume and apply TikTok-derived strategies without critical evaluation, contributing to the casualization and deprofessionalization of the profession. Ethical concerns, including student privacy, influencer-driven monetization, and digital professionalism, further complicate its role in teacher education. Grounded in Critical Media Literacy (CML) and Critical Discourse Analysis (CDA), this study argues for explicit media literacy training in …


Creating A Co-Teaching Plc To Help Find Practical Solutions For Problems In Co-Teaching At A Suburban Middle School, Rachel Siân Machens May 2025

Creating A Co-Teaching Plc To Help Find Practical Solutions For Problems In Co-Teaching At A Suburban Middle School, Rachel Siân Machens

Dissertations

The research focused on addressing equity and communication challenges in co-teaching through the implementation of a Professional Learning Community (PLC) and peer mentoring within a suburban middle school. The study took place in a predominantly white, lower-middle-class suburban school that utilized co-teaching across various subjects to provide students with disabilities greater access to the general education curriculum in the least restrictive environment. The primary objective was to establish a PLC composed of co-teachers from different disciplines, leveraging existing co-teacher training strategies to improve equity and communication within co-teaching partnerships. The PLC operated through an online forum, where the researcher, serving …


Experimental Study Of Novel Bcsa Scc Repair Materials And Implications On Corrosion In Bcsa Concrete Structures, Elizabeth S.M. Poblete May 2025

Experimental Study Of Novel Bcsa Scc Repair Materials And Implications On Corrosion In Bcsa Concrete Structures, Elizabeth S.M. Poblete

Graduate Theses and Dissertations

Some current building codes for structural concrete allow the use of alternative cement concrete if their structural, durability, and fire performance can be shown to be comparable to portland cement (PC) concrete. One such alternative cement, belitic calcium sulfoaluminate (BCSA) cement, is a promising standalone replacement for portland cement given its lower global warming potential (GWP), fast setting time, and high early age compressive strength. These properties also make it an ideal repair material. But repair materials often need to be highly flowable and easy to consolidate and their performance when used to repair PC concrete structures must be understood. …


An Exploratory Study Of Instructional Practices Inventory And School Culture Survey, Morgan Wilhoit May 2025

An Exploratory Study Of Instructional Practices Inventory And School Culture Survey, Morgan Wilhoit

All-Inclusive List of Electronic Theses and Dissertations

Much research has allowed for in-depth analyses of student engagement, a growing issue in education, without uncovering a solution. The purpose of this study was to analyze the relationship between school culture and student engagement, a connection not yet studied, by using two valid and reliable instruments, the School Culture Survey and Instructional Practices Inventory among Indiana Principal Leadership Institute elementary schools. Data were gathered quantitatively, as well as qualitatively, to determine that there is no statistically significant relationship between culture and engagement. While the schools varied in culture results and qualitative observations, the engagement levels remained the same, regardless …


Who Gets To Have Fun? The Alternative Earmarking Of A Memecoin Marketplace, Mia Tanner May 2025

Who Gets To Have Fun? The Alternative Earmarking Of A Memecoin Marketplace, Mia Tanner

Sociology Honors Projects

Past research on cryptocurrency has highlighted its sociotechnical aspects, framing crypto projects as community-grounded movements disrupting traditional state and market structures through technological advancements. What happens when these disruptive promises are absent or only playfully invoked? Cryptocurrencies known as “memecoins” have grown their own followings without pledging future legitimacy that would seriously challenge existing institutions, instead linking their value to the meme they brand themselves with and vague democratic promises. That new scheme of valuation is especially evident in coins launched on the site pump.fun, which has lowered the barriers to crypto-coin creation. The platform's accessibility provides a new dimension …


Artificial Intelligence In Immigration Law: A Practical Solution For Business Owners, Andrew H. Stevenson May 2025

Artificial Intelligence In Immigration Law: A Practical Solution For Business Owners, Andrew H. Stevenson

International Business Undergraduate Honors Theses

This thesis investigates the capabilities of artificial intelligence in immigration law, specifically through the development of a generative pre-trained transformer (GPT). This thesis aimed to create a GPT tailored to small businesses in the Northwest Arkansas region while offering industry-specific guidance in transportation, food, and manufacturing. The development and improvement of this GPT demonstrate the abilities of artificial intelligence in assisting small businesses navigate the legal field surrounding immigration law, providing immense cost and time savings.


Rare Jugular Bulb Tumor Presenting As Bilateral Papilledema, Yoona Choe, Matthew Boyle, Peter Maduka May 2025

Rare Jugular Bulb Tumor Presenting As Bilateral Papilledema, Yoona Choe, Matthew Boyle, Peter Maduka

Rowan-Virtua Research Day

Optic disc edema, which may arise from a range of inflammatory, ischemic, compressive, infiltrative, or hereditary causes, can also indicate elevated intracranial pressure in the form of papilledema. Given its potential association with life-threatening conditions such as mass lesions or venous sinus thrombosis, timely identification and thorough evaluation are critical. In this case, a 61-year-old female presented with a complaint of a new-onset floater in her left eye. Despite minimal symptoms and an unremarkable systemic review, dilated fundus examination revealed bilateral optic disc edema with hyperemia and hemorrhages, prompting urgent neuroimaging. MRI and MRV identified venous thrombi in the right …


The Effective Utilization Of Artificial Intelligence (Ai) In Early Melanoma Detection, Svetlana Filiche May 2025

The Effective Utilization Of Artificial Intelligence (Ai) In Early Melanoma Detection, Svetlana Filiche

Rowan-Virtua Research Day

Background:

Melanoma, while comprising only 1% of skin cancer cases, accounts for a high mortality rate due to its ability to metastasize if not detected early. Traditional face-to-face dermatologic evaluations provide limited access to care, resulting in delayed diagnoses.

Significance:

Artificial Intelligence (AI) offers a novel approach to improve diagnostic accuracy and accessibility by alleviating strain on healthcare resources in medically underserved areas.

Methods:

A literature review was conducted using studies published in the last ten years. Eligible resources included case reports, clinical studies, clinical trials, meta-analyses, reviews, and systematic reviews in English. Studies that were repetitive or inapplicable were …


Broadening And Broadcasting The Impact Of Cardiovascular Risk Factors Among Muslim Residents Of Southern New Jersey With Special Emphasis On Opportunities Of Future Interventions And Prevention Tactics, Maikel Mansour, Ocean Alam, Samiha Hossain, Kirsten M. Carlberg, Katarina Rusinak May 2025

Broadening And Broadcasting The Impact Of Cardiovascular Risk Factors Among Muslim Residents Of Southern New Jersey With Special Emphasis On Opportunities Of Future Interventions And Prevention Tactics, Maikel Mansour, Ocean Alam, Samiha Hossain, Kirsten M. Carlberg, Katarina Rusinak

Rowan-Virtua Research Day

According to AHA and NIH, CVD includes stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease. Between 2017 and 2020, 127.9 million US adults (48.6%) had some form of CVD.

Among the target population, it was found that observing Ramadan fasting leads to an increase in total cholesterol, low-density lipoprotein cholesterol, and triglycerides levels post-fasting. Yet, Islam emphasizes the importance of physical health as a privilege from God (Allah (swt)) and is seen as a religious duty.

The objective of the HCOP service project was to investigate the …