Digital Commons Network^™

Between Classic Social Contract Theory And Hegelian State: A Case For Freedom’S Broader Conception, Gerald Chibueze Azike

Electronic Theses and Dissertations Archive

The classic social contract theorized by Hobbes, Rousseau, and Locke advocates for establishing the state based on individual freedom; for them, a contractual agreement rather than nature serves as the foundation for the state. In his Philosophy of Rights, Hegel rejects this classic view of the social contract, which sees freedom and consent as the basis of the state. While the perspectives of the classic social contract and Hegel yield differing interpretations of freedom, the dissertation explores their relationship against contemporary challenges to freedom. It investigates the extent to which the classic social contract' s conception of subjective freedom, which …

Minimizing Grief And Loss Through Advance Care Planning, Hannah Paauw, Victoria Walker

Scholarship Pathways Program

Advanced Care Planning (ACP) is a process used to identify or update a specific patient’s preferences of care and treatment in the event that they lack the capacity to do so. ACP is especially important for the aging population and those living with chronic conditions. Currently 11% of the world’s population is above the age of 60 and this number is projected to climb to 22% by 2050. The effects of aging are even greater in rural areas, such as South Dakota, where there is a disproportionate number of older and sicker people.

This study examined the effectiveness of a …

School Nurses' Role In Creating A Culture Of Preparation For Cardiac Emergencies, Dena L. Hinkle, Marisa A. Dressler, Katherine M. Miller, Shannon L. Beetz

Nursing Department Graduate Presentations/Conferences

Recent legislation in Illinois schools has focused on enhancing cardiac preparation in schools by establishing written emergency plans that are to be disseminated to employees within thirty days from the start of the school year. This web-based education tool was created as a centralized hub for employees to locate pertinent information regarding cardiac emergencies. The intent is to increase cardiac emergency preparedness in schools with access to evidence-based resources and content. The project began by performing a literature review to collect data on cardiac emergencies within the school, leading to the development of the web-based educational portal. The Cognitive Theory …

Associations Of Muscular And Cardiovascular Fitness Variables With Cardiovascular Disease In Older Adult Athlete Populations, Lauren T. Zick

Honors Thesis

This data analysis examined associations between cardiovascular and muscular fitness indicators and the presence of cardiovascular disease (CVD) in older adult athletes. Using cross-sectional data from 1,110 participants aged 50 and older who completed the Sustained Athlete Fitness Exam (SAFE) at state-level Senior Games events, we evaluated both objective performance metrics and self-reported exercise behaviors. Cardiovascular measures included systolic blood pressure (SBP), waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI). Muscular fitness was assessed through grip strength, maximum walking speed, and chair stand time. CVD status was defined as the presence of two or more self-reported cardiovascular …

Integrating Music Content Into The Secondary Mathematics Classroom: Facilitating The Process Of Designing Interdisciplinary Lessons, Denae Bumpus

Honors Projects

Many people enjoy music, and music has a multitude of connections to mathematics, so it makes sense for a mathematics classroom to incorporate musical elements into the instruction, but the literature has shown that many math teachers do not have a strong enough musical background to feel confident in incorporating music into the math class. Therefore, this research sought to provide a resource to help secondary mathematics teachers integrate age-appropriate musical applications to their mathematics lessons which connects standards of mathematics into standards of music. Specifically, the paper connects the Ohio Standards of Mathematics for Geometry with the course objectives …

Depalmitoylation Regulates Metabolism And Mitochondrial Function, Sarah Lilly Speck

Arts & Sciences Graduate Student Theses and Dissertations

Tens of millions of Americans suffer from metabolic disorders, predisposing patients to cardiovascular disease, kidney disease, liver disease, infertility, and cancer. Unfortunately, the etiology of many of these diseases remains a mystery, limiting our ability to identify targets for pharmacologic therapies. Due to the relationship between altered lipid dynamics and metabolic dysfunction, we decided to study the effect of the posttranslational lipid modification, S-palmitoylation, on metabolism. S-palmitoylation is the only known reversible lipid modification for proteins, and this depalmitoylation process is catalyzed by acyl-protein thioesterases including APT1 and APT2. We hypothesized that APT deficiency in various tissues would predispose mammals …

High-Quality Factor Phase Gradient Metasurfaces With Dynamic Reconfigurability, Lin Lin

Arts & Sciences Graduate Student Theses and Dissertations

Free-space optical communication holds immense potential for surpassing the bandwidth limitations of conventional physically defined channels. Achieving flexible and efficient communication in free space requires compact, robust optical components capable of dynamically tuning laser light without relying on bulky lenses or mechanically driven mirrors. Metasurfaces, or flat optics, have garnered significant attention due to their densely arranged subwavelength nano-resonators, which impart phase, amplitude, and polarization changes comparable to those of traditional bulky optics. However, conventional phase gradient metasurfaces are constrained by passive designs based on geometric configurations and the weak light-matter interaction inherent in most dielectric materials, limiting their applicability …

Expanding The Druggable Proteome By Integrating Deep Learning With Molecular Simulations To Predict Cryptic Pockets, Artur Meller

Arts & Sciences Graduate Student Theses and Dissertations

Of the protein structures deposited in the Protein Data Bank, less than half have pockets suitable for the binding of drugs. Even when proteins contain pockets in their ground state structures (e.g., the nucleotide-binding active site in myosin motors), achieving specificity remains a central challenge in drug design as many protein families share common structural motifs. Cryptic pockets are cavities absent in ligand-free experimental structures that form due to protein fluctuations in solution. They provide a means to specifically target proteins currently considered undruggable. While cryptic pockets are alluring drug targets, it remains difficult to predict which proteins will form …

Enhancing Strategies For Government Partnerships To Meet Organizational Goals And Objectives, Nuela Uche Umeh

Walden Dissertations and Doctoral Studies

Organization X’s mission to strengthen legal rights and rehabilitate inmates involves effective collaboration with government entities. Organization X struggled to build strong partnerships with government agencies, limiting its ability to provide legal aid and rehabilitation services to marginalized inmates and victims of human rights violations. The purpose of this study was to use a SWOT analysis to explore the challenges and opportunities in government partnerships, aiming to identify barriers and recommend strategies to strengthen collaboration, build staff capacity, and enhance service delivery. Guided by four research questions, the study examined barriers and opportunities in government partnerships. Data were collected through …

Nurse Practitioner And Physician Assistant Staffing To Bridge Physician Shortages In North Carolina Rural Clinics, Robin Alisha Tyson

Walden Dissertations and Doctoral Studies

Physician shortages in North Carolina rural counties are a problem that continues to affect patient care, which has necessitated the need to use other disciplines such as nurse practitioners (NPs) and physician assistants (PAs). The purpose and review question for this integrative review focused on determining best practices for utilizing PAs and NPs in rural clinics and how these staffing options could improve health outcomes. The administrative management theory served as the framework for this project by emphasizing the functions of planning, organizing, coordinating, and teamwork. A search of both empirical and nonempirical literature for years 2019 through 2024 was …

Use Of Mindfulness To Promote The Spiritual And Religious Competencies Of Master’S Level Counseling Students., Luisa Nayhouse

Electronic Theses and Dissertations

This research aimed to evaluate the effectiveness of a two-and-a-half hour training session for master's students in counselor education. The training focused on using mindfulness to enhance spiritual and religious counseling competencies. Utilizing a pre-and post-test design, the quantitative study employed mindfulness to train master's students with the aim of building and fostering spiritual and religious competencies in counseling. Historically, there has been a lack of research on the benefits of such specific mindfulness training related to this subject matter.

The study targeted master's level counselor students, with potential applicability to related fields such as psychology and social work. This …

A Study Of Social And Emotional Learning Provision To Kindergarten Students In A Rural School Through The Lens Of Whole Child Development, Shirley Spiegel

Electronic Theses and Dissertations

The purpose of this Improvement Science Project was to take appraisal of a rural school district’s current approach for developing the whole child in kindergarten. Three prominent context-based child development theories serve as the framework for this study in determining if there is evidence in practice for support of whole child development, or if those practices or components of the current practices do not demonstrate clear evidence for whole child development, according to the theoretical framework. Conducted through the lens of these whole child development theories, this study centered on the Social and Emotional Learning (SEL) provision to kindergarten students …

Improving Staff Knowledge And Patient Care Outcomes Through Targeted Educational Interventions On Diabetes Management In Home Health Agencies, Chikita Domonique Smith

Walden Dissertations and Doctoral Studies

No abstract provided.

Executive Watch: Zick On Executive Orders And Official Orthodoxies, Timothy Zick

Popular Media

During his first term as president, Donald Trump signaled that he was not committed to pluralism and expressive liberty when it came to matters like patriotism, public protest, and other forms of dissent. During his second term, Trump has issued multiple executive orders that attempt to impose official orthodoxies or understandings regarding race, gender, patriotism, and other subjects.

As we have seen, these edicts are not merely symbolic. The executive orders call for agency actions and criminal investigations, and place hundreds of millions of dollars in federal funding at risk. The orders have affected what universities teach, which immigrants can …

Simplicity From Complexity: Sensing High-Dimensional Fluctuations Via Regulatory Network, Optimality In Allocating Cellular Resources, And Recovering Functional Groups Via Data-Driven Methods, Fang Yu

Arts & Sciences Graduate Student Theses and Dissertations

Biological systems must navigate dynamic and complex environments while operating under constraints such as limited molecular resources, biochemical noise, and structural trade-offs. This dissertation investigates three distinct cases in which biological systems allocate resources and process information efficiently, revealing emergent simplicity from underlying complexity. The first study develops a generalized end-product inhibition model with cross-talk and an excess of regulators, providing a proof-of-principle that simple biochemical circuits could, in principle, dynamically adjust their responsiveness to high-dimensional environmental variation. This result highlights how such circuits may allow adaptive filtering of both dominant and subdominant fluctuation modes. The second study, conducted in …

Pan-Cancer Universal Targets For Immunotherapy Resulted From Transposable Elements Activation, Yonghao Liang

Arts & Sciences Graduate Student Theses and Dissertations

Transposable elements (TEs) contribute to nearly half of the human genome yet have been overlooked in genomic medicines due to the stereotypic impression as “junk DNA” and technical challenges. However, studies in the last two decades demonstrated that dysregulation of the epigenome in cancer cells resurrects the cis-regulatory functions of TEs, including the promoter activities. The tumor-specific TE activation events along with the resulting tumor-specific RNA and protein molecules, provide a potential “gold mine” for identifying tumor-specific therapeutic targets for cancer treatments, including immunotherapy. Here, I present a series of works to investigate the potential of providing actionable, pan-cancer, and …

Mechanisms Of Mll-Rearranged Infant Leukemogenesis, Jonny Mendoza-Castrejon

Arts & Sciences Graduate Student Theses and Dissertations

Infant leukemias arise as either B cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) and are primarily driven by MLL/KMT2A-rearrangements (MLLr). Prior work has shown that MLLr transform fetal/neonatal hematopoietic progenitors more efficiently than adult progenitors. However, the genetics and epidemiology of MLLr leukemias present an important paradox. MLLr arise during late gestation under conditions that would seemingly favor leukemic transformation (i.e., fetal/neonatal progenitors have high proliferation rates and self-renewal). Furthermore, MLLr infant leukemias require very few cooperating mutations for transformation. Yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less common than childhood leukemias …

Oxycodone Self-Administration Modulates Ventral Pallidal Neuron Activity And Plasticity, Jessica Tooley

Arts & Sciences Graduate Student Theses and Dissertations

Opioid use disorder is an urgent public health crisis in the United States. Over 800,000 Americans have died from opioid-related overdoses since 2000. Nearly 30% of people who misuse opioids begin with prescription oral opioids, such as oxycodone, and continue misusing to avoid the immediate aversive state of withdrawal and the persistent dysphoria associated with protracted abstinence from opioids. The persistency of these dysphoric symptoms increases the risk of relapse even after long periods of abstinence. Treatment for opioid use disorder currently consists of pharmacological opioid treatment to reduce withdrawal symptoms and behavioral counseling. However, these strategies have significant real-world …

Parental Guidance Suggested: Genetic, Epigenetic, And Environmental Factors Shape Allele-Specific Gene Regulation In Metabolic Traits, Celine Louise St. Pierre

Arts & Sciences Graduate Student Theses and Dissertations

Deciphering the “genotype to phenotype” map is a crucial goal of biology. We will not improve our ability to predict phenotypes from DNA sequences until we better incorporate epigenetic and environmental variation into our models of human health and disease. Genes are typically presumed to express both parental alleles equally, but genetic and epigenetic factors can cause one allele to function differently than the other (e.g. expressed or silenced more). These allele-specific imbalances can alter the final composition of a gene’s transcriptional product and ultimately shape phenotypes. Allele-specific effects have widespread impacts on complex traits, but how environmental signals contribute …

Induced Cd8a Identifies Enhanced Human Nk Cell Il-15-Induced Proliferation And Metabolism And Modulates Nk Cell Activation, Celia Cubitt

Arts & Sciences Graduate Student Theses and Dissertations

Natural Killer (NK) cells are cytotoxic innate lymphoid cells that play an important role in the surveillance and elimination of virally-infected and malignantly-transformed cells. These primary effector functions are achieved by producing cytokines and chemokines which activate and recruit additional immune effectors, as well as direct cytotoxic killing via perforin and granzymes. NK cell function is tightly regulated by a balance of germ-line encoded activating, inhibitory, co-stimulatory, and cytokine receptors expressed at the cell surface. Through these activating and inhibitory receptors, NK cells recognize and kill targets without prior sensitization through the loss of self-identifying molecules such as major histocompatibility …

Improved Outcomes Of Acute Lymphoblastic Leukemia After Allogeneic Blood Or Marrow Transplantation With High-Dose Post-Transplantation Cyclophosphamide In The Era Of More Effective Pre-Transplant Therapy, Jonathan A Webster, Madison Reed, Hua-Ling Tsai, Philip H Imus, Douglas B Smith, Alexander J Ambinder, Mark J Levis, Amy E Dezern, Gabrielle T Prince, Tania Jain, Javier Bolaños-Meade, Lukasz P Gondek, Gabriel Ghiaur, William Brian Dalton, Theodoros Karantanos, Suman Paul, Ephraim J Fuchs, Cole Sterling, Lode J Swinnen, Nina Wagner-Johnston, Richard F Ambinder, Christian B Gocke, Syed Abbas Ali, Carol Ann Huff, Leo Luznik, Ravi Varadhan, Richard J Jones, Ivana Gojo

Faculty, Staff and Students Publications

The therapeutic landscape in ALL has changed dramatically over the last decade. Allogeneic blood or marrow transplantation (AlloBMT) has also evolved and remains an important option for consolidation. We assessed the interplay between these factors by analyzing the outcomes of 251 adult ALL (214 B and 37 T ALL) patients undergoing alloBMT with post-transplantation cyclophosphamide (PTCy) across two eras: 2008-2014 (ERA1) and 2015-2022 (ERA2). ERA1 patients were younger (median age 45.5 vs. 50, p=0.03), less likely to have an HCT-CI ≥4 (9% vs. 21%, p=0.01), more likely to have MRD by flow cytometry (20% vs. 9%, p=0.01) and receive myeloablative …

Human Genetic Variation Determines 24-Hour Rhythmic Gene Expression And Disease Risk, Ying Chen, Panpan Liu, Aniko Sabo, Dongyin Guan

Faculty, Staff and Students Publications

24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these rhythms increases the risks of multiple diseases. Biological rhythms are known to have a genetic basis formed by core clock genes, but how individual genetic variation shapes the oscillating transcriptome and contributes to human chronophysiology and disease risk is largely unknown. Here, we mapped interactions between temporal gene expression and genotype to identify quantitative trait loci (QTLs) contributing to rhythmic gene expression. These newly identified QTLs were termed as rhythmic QTLs (rhyQTLs), which determine previously unappreciated rhythmic genes in human subpopulations with specific genotypes. Functionally, rhyQTLs and their …

Development Of A Risk Score To Aid With The Diagnosis Of Infections After Spinal Cord Injury: Protocol For A Retrospective Cohort Study, Felicia Skelton, Larissa Grigoryan, Joann Pan, Ashley Collazo, Barbara Trautner

Faculty, Staff and Students Publications

Background: Patients with spinal cord injury (SCI) who develop urinary tract infection (UTI) present differently than the non-SCI population. UTIs can cause loss of quality of life and even lead to life-threatening complications including urosepsis. Challenges in SCI management include distinguishing symptomatic UTI from asymptomatic bacteriuria (ASB), which occurs often in patients with SCI, and the lack of standardization in UTI diagnosis in SCI.

Objective: This study aims to set the foundation for the development of a risk score to improve diagnostic accuracy of UTI after SCI.

Methods: This study will use data from the Veterans Health Administration Corporate Data …

"Significant Bodily Intrusions": Investigations Into Law Enforcement Phlebotomy, Anne Kathleen Johnson

Dissertations and Theses

This three-paper dissertation explores law enforcement phlebotomy, the ability of law enforcement officers to draw blood. Phlebotomy is both a ubiquitous, invasive diagnostic tool as well as a social site with complex relational dynamics at play between phlebotomist and patient. Through law enforcement phlebotomy, the blood draw is co-opted from the medical field into the policing field, and the normative framework through which it is used changes: whereas medical edicts instruct providers to work with patients through an ethics of care--respecting consent and refusal--policing is not similarly bound, instead operating through a prioritization of security and efficiency. In the articles …

Magma Evolution And Eruptive History Of Three Fingered Jack: A Mafic Composite Volcano In The Central High Cascades Of Oregon, Javaria Aziz

Dissertations and Theses

The central High Cascades graben in Oregon has been a center for mafic volcanism since its initiation. Three Fingered Jack is one of the larger mafic composite cones in the graben, located 20km south of Mount Jefferson. Three Fingered Jack erupted between 142.1 - 150.8ka, based on Ar⁴⁰/Ar³⁹ age dates. This study provides stratigraphic, compositional and petrographic evidence to understand the eruptive history of Three Fingered Jack and the processes involved in generating compositionally diverse basaltic andesites here.

The basaltic andesites of Three Fingered Jack show three compositional trends of magma evolution: 1) enrichment, 2) depletion and …

Hadzovic V. Buckley Sch. In The City Of N.Y.

All Decisions

The tenant sought declaratory and injunctive relief, alleging rent overcharges and improper deregulation of his apartment. After purchasing the building, the landlord moved for summary judgment, claiming a lawful high-rent deregulation occurred in 2009. The tenant countered that the apartment had been used commercially by a prior tenant, disqualifying it from deregulation. The motion court had granted the landlord summary judgment and ejectment. On appeal, the court reversed, holding triable issues of fact remained regarding the apartment's actual use and whether deregulation was proper. The court emphasized that questions concerning mixed commercial and residential use must be resolved by a …

Sirt6 Deficiency Promotes Senescence And Age-Associated Intervertebral Disc Degeneration In Mice, Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria Tran, Shira N Johnston, Maria Tsingas, Ruteja Barve, Ramkrishna Mitra, Richard Loeser, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan^CreERT2; Sirt6^fl/fl). Histological studies showed a degenerative phenotype in knockout mice …

A Novel Way Of Conceptualizing And Measuring Situation Selection, Jiyoung Kwak

Arts & Sciences Graduate Student Theses and Dissertations

Situation selection is a form of emotion regulation where people approach or avoid certain things, places, or objects to proactively regulate their emotions. Though it is the only strategy that occurs before encountering emotion-eliciting events, situation selection remains understudied. The present research proposes a new measure of Day Recollection Situation Selection (DRSS) in which participants are prompted to recall the day's events before reporting their approach and avoidance behaviors. Across two studies, we aimed to: (1) develop the DRSS measure, (2) compare it to existing measures of situation selection and well-being, (3) examine within- and between-person variability, and (4) compare …

An Intervention To Empower People To Confront Sexism, Rebecca Grace Drake

Arts & Sciences Graduate Student Theses and Dissertations

Even though sexist comments and behavior occur frequently in everyday life, people do not often confront the individuals who are responsible. However, interpersonal bias confrontations can be powerful tools for reducing expressions of bias and norm setting. The current studies tested an intervention designed to increase confrontations by harnessing theory and research on what holds people back from confronting. We designed a half-hour intervention consisting of engaging and evidence-based videos on confronting bias and self-reflection exercises to increase personal relevance. The module aimed to boost confronting by intervening at multiple points of the decision-making process by increasing recognition of sexism, …

Topological And Optical Properties Of Two-Dimensional Materials, Haonan Wang

Arts & Sciences Graduate Student Theses and Dissertations

Recent advances in condensed matter physics have revealed a wide range of novel quantum phenomena in two-dimensional (2D) materials. The discovery of unique topological, magnetic, and optical properties in solids has greatly expanded our understanding of quantum phases in electronic structures. As more material systems are proposed theoretically and realized experimentally, our research focuses on uncovering and explaining these phenomena through effective models and first-principles calculations. First, we explore topological mosaic patterns in moiré superlattices—structures composed of periodic, spatially distinct domains, each with different topological properties. These domains give rise to periodic edge states along domain walls. We explore the …