Digital Commons Network^™

Open Textbook Pilot Program Budget Template, Sammi Williams

Grant Proposal Documents

This Excel spreadsheet serves as a budget template for applicants of the Open Textbook Pilot Program, a grant initiative designed to support the development and adoption of open educational resources (OER). The template is structured to help institutions and project teams itemize and justify expenses related to the creation, adaptation, and dissemination of open textbooks. It includes categorized sections for personnel, fringe benefits, travel, equipment, materials, contractual services, and other costs, ensuring compliance with federal grant budget requirements.

Short Communication: Multiscale Topographic Complexity Analysis With Pytopocomplexity, L. S.-H. Lai, Adam Booth, A. R. Duvall, E. Herzig

Geology Faculty Publications and Presentations

TopoComplexity is a Python package designed for efficient and customizable quantification of topographic complexity using four advanced methods: two-dimensional continuous wavelet transform analysis, fractal dimension estimation, rugosity index, and terrain position index calculations. This package addresses the lack of open-source software for these advanced terrain analysis techniques essential for modern geomorphology and geohazard research, enhancing data comparison and reproducibility. By assessing topographic complexity across multiple spatial scales, pyTopoComplexity allows users to identify characteristic morphological scales of studied landforms. The software repository also includes a Jupyter Notebook that integrates components from the surface-process modeling platform Landlab (Hobley et al., 2017), facilitating …

Having A Cow: Exploring The Economic And Mental Health Challenges Of Dairying In The Upper Valley, Ava J. Ori

Environmental Studies Senior Theses

Until late in the 20th century, the dairyman was an influential actor in the fabric of the Upper Valley consisting of Grafton, Orange, Sullivan and Windsor counties (Rozwenc, 1981 & Weld, 1905). Dairy farmers were critical to both the economic growth of the region and the construction of a local identity centered around distinctive high quality dairy products. However, the dairy farmers responsible for the bucolic feel and scrappy independence unique to the Upper Valley are being traded in for massive operations lacking both quality of milk and the cultural intricacy specific to local dairies. In 1905 there were 4,173 …

A Comparative Study Of Standards-Based And Traditional Grading Among Ninth-Grade Students, Senitra Lachelle Upton

Tennessee State University Alumni Theses and Dissertations

Abstract This study examined the impact of standards-based grading (SBG) on the performance of ninth-grade students in English and Mathematics from 2021 to 2023. Using a comparative research design, archival performance data from School A (SBG) and School B (traditional grading) in a public school district in Tennessee were analyzed. Independent t-tests showed that Math scores were consistently higher under traditional grading (p < .001, d = 0.53-0.70) across all years. In English, SBG students outperformed their peers in 2021 (p = .001, d = 0.32), but by 2023, traditional grading yielded higher scores (p = .002, d = 0.46). These findings challenge the assumption that SBG improves academic achievement and highlight the role of contextual factors such as teacher adaptation, implementation fidelity, and subject-specific learning demands. The decline in English performance under SBG suggests difficulties in maintaining standards alignment and student acclimatization to a mastery-based system. In contrast, traditional grading's structured point system may better support procedural retention in Mathematics. This study emphasized the need for systemic evaluation of grading reforms, considering subject-specific requirements, student behaviors, and community attitudes. While SBG aligns with mastery-oriented instruction, its effectiveness depends on addressing practical concerns, such as teacher workload, grading consistency, and assessment transparency. These findings contribute to the discourse on equity in grading and encourage policymakers to adopt evidence-driven, context-based decisions. Future research should explore subgroup variations and longitudinal effects of grading interventions to enhance diverse instructional practices. Keywords: Standards-Based Grading, Traditional Grading, Academic Achievement, Mathematics Performance

Effective Strategies For Improving Hospital Safety And Profitability Through Reducing Hospital-Acquired Conditions, Quennise Giles

Walden Dissertations and Doctoral Studies

The incidence of hospital acquired conditions (HACs) has been a persistent problem in the United States that has negatively affected patient safety, care outcomes, and hospital costs and profitability. Effective strategies to reduce HACs and improve compliance with Hospital-Acquired Condition Reduction Program (HACRP) requirements are important for hospital leaders. Grounded in the total quality management conceptual framework, the purpose of this qualitative pragmatic inquiry was to explore how six hospital leaders in the Southeast United States successfully reduced HACs and improved HACRP compliance. Data were collected through personal interviews and publicly available documents. Yin’s 5-step process was used for data …

K-8, Private, Midwestern School Principals And Their Experiences Of Work Demand, Emily Madden Roth

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study is increasing job demands and insufficient job resources plaguing K-8 principals across the nation. The purpose of this basic qualitative study was to investigate K-8 principals’ perceptions of increased work demands and their influence on excessive stress, burnout, and turnover in a private, Midwestern school district. Bakker and Demerouti’s job demands-resources theory served as the theoretical foundation for this study. Data were collected from semistructured interviews with 10 principals from the same district. Participant responses were analyzed through several rounds of coding, which led to the emergence of the following six themes: …

Minimum Ghg Emissions And Energy Consumption Of U.S. Pet And Polyolefin Packaging Supply Chains In A Circular Economy, Utkarsh S. Chaudhari, Abhishek Patil, Tasmin Hossain, David Watkins, Damon S. Hartley, Barbara K. Reck, Robert Handler, Anne T. Johnson, Vicki S. Thompson, David Shonnard

Michigan Tech Publications

There is a wide agreement on the urgency of transforming linear management of plastics towards a circular economy model. However, no clear pathways exist as to required recycling technologies involved and system-wide environmental impacts. This study explores such pathways in the U.S. for the most commonly used packaging plastics through a combination of mechanical and emerging advanced recycling technologies. A system optimization model aimed at minimizing environmental impacts was developed to determine optimal end-of-life (EOL) management and locations of existing and emerging U.S. recycling infrastructures. Our study includes material flows from virgin resin production through semi-manufacturing processes to existing EOL …

Rojas V. Cruger Associates Limited Partnership

All Decisions

In this source of income discrimination case, the plaintiff tenant, obtained a preliminary injunction preventing the landlord, from commencing a nonpayment proceeding. The court found that the landlord repeatedly obstructed tenant's attempt to use her Emergency Housing Voucher for "leasing in place" by refusing to submit necessary paperwork, citing arrears, and failing to provide a valid Tax ID. The injunction was granted to preserve tenant's voucher and residency, emphasizing the landlord's obligation under New York City and State Human Rights Laws to accept lawful sources of income.

Allelopathy Of Western Red Cedar, Douglas Fir, And Western Hemlock On Seed Germination, Lainey E. Mendoza Ms.

Honors Projects

Understanding the allelopathic interactions of native Pacific Northwest conifers, Douglas Fir, Western Hemlock, and Western Red Cedar is crucial to understanding the interactions of each species within their ecological niche. As of now there is little research on allelopathy of PNW conifers, specifically how different damaged states of the conifer tissue could impact the germination rates and radicle growth of a model organism. Analyzing these allelopathic interactions may be crucial to help predict forest regeneration of the PNW in the future. Presented here is the analysis of Douglas Fir, Western Hemlock, and Western Red Cedar tissue that is undamaged, damaged, …

Molecular Insights Into The Role Of Estrogen Receptor Beta In Ecdysterone Mediated Anabolic Activity, Syeda Sumayya Tariq, Madiha Sardar, Muhammad Shafiq, Hendrick Heinz, Mohammad Nur-E-Alam, Aftab Ahmad, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

Ecdysterone, often dubbed a “natural steroid,” has garnered significant attention among athletes for its reputed growth-promoting and anabolic properties. Unlike synthetic anabolic steroids, which are classified as controlled substances, ecdysteroids remain largely unregulated in many countries and are widely marketed as dietary supplements. Notably, ecdysterone has been included in the World Anti-Doping Agency (WADA) monitoring program, highlighting its potential impact on athletic performance and raising questions about its regulation. Emerging evidence indicates that, unlike traditional anabolic steroids that act primarily via the Androgen Receptor (AR), ecdysterone’s anabolic effects may be mediated through Estrogen Receptors (ERs), particularly Estrogen Receptor beta (ERβ). …

#Clandestini: How Italy's Center-Right Parliamentary Coalition Frames The Migrant Crisis On Social Media, Jenna Lynn Depasquale

Dissertations and Theses

This dissertation examines the intersection of Italian neo-fascism, the Mediterranean migrant crisis, and digital media. Through a qualitative content analysis of the Twitter and Instagram posts made by Italy's center-right parliamentary coalition from 2014-2018, this research outlines frameworks that facilitate both the physical and social deaths of migrants. Twitter is a platform on which bite-sized xenophobic messages characterize migrants as criminals, spoiled youth, spreaders of infectious disease, and future terrorists--sometimes in a contradictory fashion. Instagram is a medium for conveying Italian identity and history, which disregards the longstanding contributions of people of color, including Muslims, in Southern Italy. Comment sections …

What This Work Really Takes: Lessons, Tensions, And Student Perspectives In A Social Justice Math Classroom, Kathryn Elizabeth Roman

Dissertations and Theses

In recent years, there have been growing calls for mathematics instruction that engages students in understanding and critiquing injustice through mathematics. While resources for social justice math (SJM) lessons have become increasingly available, implementing these lessons in real classrooms--with real students, real time constraints, and real pressures--remains a challenge. This dissertation explores how teachers and students navigate this complexity through three connected papers.

The first paper introduces a framework to support teachers and mathematics teacher educators (MTEs) in selecting and modifying pre-designed SJM lessons (PSJMLs). The framework is organized around three guiding principles: (1) center student identity and teacher self-awareness, …

Development Of A Low-Cost Electron Microscope For Educational Purposes, Christopher Halseth

Dissertations and Theses

Electron microscopy is a powerful tool for exploring microscopic world, yet its high cost and operational complexity severely limit accessibility, particularly within educational institutions. Commercial systems are often designed as opaque "black boxes," further hindering hands-on learning and experimentation. This dissertation introduces the Educational Scanning/Transmission Electron Microscope (EduSEM), a project designed to overcome these barriers by developing a low-cost, modular, and transparent electron microscope optimized for educational use.

The EduSEM achieves significant cost reduction by operating in a rough vacuum environment (1-20 mTorr), eliminating the need for expensive high-vacuum pumps. This necessitates novel component designs tolerant of higher pressures. The …

Accessibility To Public Spaces: Intersections Between The Courts And The Houseless Community, Margaret Maxey

Dissertations and Theses

In an attempt to answer the question of what role the judiciary played in affecting access to public spaces from the 1960's to 2024, this thesis identifies an accumulation of patterns relating to the courts' role in accessibility of public parks and their amenities over this time period. The data supplied for this question is drawn from scholars focusing on judicial decisions and political theory relating to public spaces, including those mentioned above. The result of this study will include a close examination of the role the judiciary holds as a cornerstone institution in not only our democracy, but in …

Breaking The Rules: Post-Translational Modifications And Proteome Dynamics During Anoxia, Chelsea Jordan Hughes

Dissertations and Theses

Most organisms are ill-equipped to survive anoxia, but some organisms have developed molecular strategies to mitigate the cellular stressors associated with a lack of oxygen. While it is established that anoxic survival is contingent on metabolic suppression, it is unclear what mechanisms support this change in gene expression. Gene expression is regulated by a variety of mechanisms within the cell, including alteration of chromatin structure through histone modifications and protein modifications which contribute to the ever-changing proteomic landscape of the cell. Protein modifications such as ubiquitylation can lead to the degradation of proteins, while modifications to transcription factors can change …

Efficient Signal Synthesis For Data Augmentation Using Generative Ai, Yagna Veera Narayan Kaasaragadda

Theses and Dissertations

Modern signal processing AI applications face increasing demands for diverse training data while operating under computational constraints. State-of-the-art generative models, though effective, often require prohibitive resources, limiting their deployment in real-time or embedded systems. This thesis proposes a computationally efficient framework for synthetic signal generation using a two-stage architecture that combines a Vector Quantized Variational Autoencoder (VQ-VAE) with either a decoder-only transformer or a discrete diffusion model. The VQ-VAE encodes high-dimensional signals into discrete latent tokens, significantly reducing model complexity while enabling symbolic sequence modeling. These discrete representations are then modeled using transformer-based autoregressive models or Score Entropy Discrete Diffusion …

Social Experiences Of Individuals With Autism In Adolescence And Adulthood: A Literature Review, Nichole Dumlao, F. Richard Ferraro

Arts & Sciences Undergraduate Showcase

This literature review examines social experiences of individuals with Autism Spectrum Disorder (ASD) during adolescence and adulthood, addressing a critical knowledge gap regarding developmental trajectories and support needs across the lifespan. Despite increased ASD awareness, individuals face persistent social challenges, with research showing concerning rates of isolation. The purpose of this review is to understand how sensory processing differences and atypical gaze behaviors contribute to social outcomes in ASD. As such, three key questions were asked: How do social participation patterns change from adolescence to adulthood? What sensory-based subtypes exist within ASD? How do different gaze behavior patterns relate to …

Cisplatin Palbociclib Combination Differentially Modulates Pten Akt Signaling Via Hsp90 In Hepatocellular Carcinoma Cells., Eman Ramadan

Pharmacy

Hepatocellular carcinoma (HCC) presents a significant global health challenge, marked by high mortality and recurrence. This study investigated the synergistic potential of cisplatin and palbociclib (C + P) against HCC cell lines. RT-qPCR revealed that C + P significantly downregulated HCC-related genes, including Hsp90, β-catenin, and components of the PI3K/AKT/mTOR pathway, compared to cisplatin alone and controls. Western blotting confirmed a reduction in phosphorylated AKT (P-AKT) with palbociclib and C + P, while PTEN, a tumor suppressor, was upregulated in the C + P group. Annexin V-FITC assays demonstrated a substantial increase in apoptosis in palbociclib and C + P …

Unh Police Sergeant Balances The Badge And The Books, Aaron Sanborn

UNH Today Archive

No abstract provided.

Advances In And Applications Of Capillary Scale Liquid Chromatography, Samuel William Foster

Theses and Dissertations

Analytical-scale high performance liquid chromatography (HPLC) is one of the most widely used analytical techniques in the world. Efforts have been made to reduce the mobile phase consumption of HPLC by reducing the inner diameter (I.D.) of the column. By using capillary-scale columns (< 0.5 mm I.D.), separations can be performed with orders of magnitude less solvent consumption. This work describes advances made to capillary scale instrumentation as well as applications enabled by these advances. A compact capillary-scale LC was used for the analysis of numerous pharmaceutical and illicit drug compounds for point of need analysis. A miniaturized mass spectrometer was coupled to this instrument for on-line reaction monitoring within a standard chemical fume hood. Kinetic profiles of commercially available capillary columns were developed in order to provide guidance to others during column selection. The implementation of a column oven improved the analysis of large biopharmaceuticals. Several critical quality attributes of monoclonal antibodies including fragmentation, charge variants, and glycosylation profiles were able to be determined on the capillary scale. These results will help to make capillary-scale liquid chromatography a more viable solution for chromatographic analysis.

Study Examines How Well Wearable Tech Tracks Fitness Metrics, Jordan Karnbach

University of Mississippi News

OXFORD, Miss. – Many Americans rely on their Apple Watches or similar devices each day to count their steps, track workouts, and measure how many calories they burn. But are those wearable devices accurate?

The Effects Of Post Activation Potentiation Using Accommodating Resistance, Brennan Sweet

Doctorate in Kinesiology

Post activation potentiation is the short increase of power output following a heavy exercise. This effect could be due to several mechanisms, the most popular are increased sensitivity of actin and myosin to calcium or alpha motoneuron reactivity. The idea behind using the accommodating resistance is that eccentrics get lighter throughout the movement to avoid sticking points whilst changing the strength curve of the exercise. This may cause a greater stretch reflex and create more force from the weakest position of the movement because of the eccentrics being quicker also known as. Using accommodating resistance may also be less fatiguing …

Social, Microbial, And Immune Factors Linking Bacterial Vaginosis And Infectious Diseases, Nicole M. Gilbert, Luis A. Ramirez Hernandez, Daniela Berman, Sydney Morrill, Pascal Gagneux, Amanda L. Lewis

2020-Current year OA Pubs

Bacterial vaginosis (BV) is a polymicrobial condition of the vaginal microbiota associated with a variety of sexually transmitted infections, infections of maternal and fetal tissues during pregnancy, and even some infections outside of the reproductive tract, including the urinary tract and mouth. BV has also been associated with conditions in which the body generates prominent inflammatory reactions to microbes, including infections of the cervix and other upper genital tract tissues. For reasons still not understood, BV is a highly recurrent and often difficult-to-treat condition, complicating attempts to prevent these associated infections. An additional layer of complexity arises from the increasing …

Identification Of A Seasonal Influenza Vaccine-Induced Broadly Protective Neuraminidase Antibody, Anders Madsen, Nisreen M A Okba, Tossapol Pholcharee, Hanover C Matz, Huibin Lv, Maria Ibanez Trullen, Julian Q Zhou, Jackson S Turner, Aaron J Schmitz, Fangjie Han, Stephen C Horvath, Sameer Kumar Malladi, Florian Krammer, Nicholas C Wu, Ali H Ellebedy

2020-Current year OA Pubs

Seasonal influenza viruses cause significant global illness and death annually, and the potential spillover of avian H5N1 poses a serious pandemic threat. Traditional influenza vaccines target the variable hemagglutinin (HA) protein, necessitating annual vaccine updates, while the slower-evolving neuraminidase (NA) presents a promising target for broader protection. We investigated the breadth of anti-NA B cell responses to seasonal influenza vaccination in humans. We screened plasmablast-derived monoclonal antibodies (mAbs) from three donors, identifying 11 clonally distinct NA mAbs from 268 vaccine-specific mAbs. Among these, mAb-297 showed exceptionally broad NA inhibition, effectively protecting mice against lethal doses of influenza A and B …

Dominant Interfering Card11 Variants Disrupt Jnk Signaling To Promote Gata3 Expression In T Cells, Bradly M Bauman, Jeffrey R Stinson, Melissa A Kallarakal, Lei Haley Huang, Andrew M Frank, Gauthaman Sukumar, Nermina Saucier, Clifton L Dalgard, Alice Y Chan, Joshua D Milner, Megan A Cooper, Andrew L Snow

2020-Current year OA Pubs

Several "primary atopic disorders" are linked to monogenic defects that attenuate TCR signaling, favoring T helper type 2 (TH2) cell differentiation. Patients with CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS) disease suffer from severe atopy, caused by germline loss-of-function/dominant interfering (LOF/DI) CARD11 variants. The CARD11 scaffold enables TCR-induced activation of NF-κB, mTORC1, and JNK signaling, yet the function of CARD11-dependent JNK signaling in T cells remains nebulous. Here we show that CARD11 is critical for TCR-induced activation of JNK1 and JNK2, as well as canonical JUN/FOS AP-1 family members. Patient-derived CARD11 DI variants attenuated WT CARD11 JNK signaling, …

Deriving A Mammogram-Based Risk Score From Screening Digital Breast Tomosynthesis For 5-Year Breast Cancer Risk Prediction, Shu Jiang, Debbie L Bennett, Graham A Colditz

2020-Current year OA Pubs

Screening digital breast tomosynthesis (DBT) aims to identify breast cancer early when treatment is most effective, leading to reduced mortality. In addition to early detection, the information contained within DBT images may also inform subsequent risk stratification and guide risk-reducing management. Using transfer learning, we refined a model in the Joanne Knight Breast Health Cohort at Washington University, a cohort of 5,066 women with DBT screening (mean age, 54.6), among whom 105 were diagnosed with breast cancer (26 ductal carcinoma in situ). We applied the model to external data from the Emory Breast Imaging Dataset, a cohort of 7,017 women …

Irx2 And Nptx1 Differential Regulation Of Β-Catenin Underlies Mek-Mediated Proliferation In Human Neuroglial Cells, Alexander Chen, Hannah Wang, Xuanwei Li, Corina Anastasaki, David H Gutmann

2020-Current year OA Pubs

The two major genomic alterations in pediatric pilocytic astrocytoma (PA) are

Validation Of A Dynamic Risk Prediction Model Incorporating Prior Mammograms In A Diverse Population, Shu Jiang, Debbie L Bennett, Graham A Colditz

2020-Current year OA Pubs

IMPORTANCE: For breast cancer risk prediction to be clinically useful, it must be accurate and applicable to diverse groups of women across multiple settings.

OBJECTIVE: To examine whether a dynamic risk prediction model incorporating prior mammograms, previously validated in Black and White women, could predict future risk of breast cancer across a racially and ethnically diverse population in a population-based screening program.

DESIGN, SETTING, AND PARTICIPANTS: This prognostic study included women aged 40 to 74 years with 1 or more screening mammograms drawn from the British Columbia Breast Screening Program from January 1, 2013, to December 31, 2019, with follow-up …

Charting The Regulatory Landscape Of Tp53 On Transposable Elements In Cancer, Xuan Qu, Yonghao Liang, Colin Mccornack, Xiaoyun Xing, Heather Schmidt, Chad Tomlinson, Catrina Fronick, Edward A Belter, Juan F Macias-Velasco, Ting Wang

2020-Current year OA Pubs

The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more clarity in TP53's roles in cancer. In this study, we characterized the TE transcriptomic landscape using long-read RNA-seq and short-read RNA-seq in three cancer cell lines varying only in

Innate Lymphoid Cells In Inflammatory Bowel Disease, Xin Yao, Kaiming Ma, Yangzhuangzhuang Zhu, Siyan Cao

2020-Current year OA Pubs

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract with rising incidence and an unclear etiology. Innate lymphoid cells (ILCs) have recently emerged as key regulators of mucosal immunity and tissue homeostasis and are increasingly implicated in IBD. Unlike adaptive lymphocytes, ILCs do not require antigen recognition and clonal expansion to respond rapidly to environmental cues and shape immune responses. In a healthy gut, ILCs maintain intestinal homeostasis by guarding the epithelial barrier, protecting against pathogens, and mounting proper responses to external insults. However, their altered differentiation, proliferation, recruitment, activation, …